Saturday, September 3, 2016

Herbal therapy: Popular Herbal Slippery Elm(Ulmus rubra)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                          Slippery elm (Ulmus rubra)



Slippery elm is a genus Ulmus, belonging to the family Ulmaceae, native to eastern North America. The herb has been used in traditional medicine to treat wounds, boils, ulcers, burns, skin inflammation, relieve coughs, sore throats, diarrhea, stomach problems, etc.

Health Benefits
1. Antioxidant and anti cancer effects
In the determination the antioxidant and anti cancer effects of Essiac, a tea prepared from a mixture of four herbs Arctium lappa, Rumex acetosella, Ulmusrubra and Rheum officinale,
found that Essiac inhibited hydroxyl radical-induced lipid peroxidation by up to 50% at the 50% tea preparation concentration. These data indicate that Essiac tea possesses potent antioxidant and DNA-protective activity, properties that are common to natural anti-cancer agents. This study may help to explain the mechanisms behind the reported anti-cancer effects of Essiac, according to "Essiac tea: scavenging of reactive oxygen species and effects on DNA damage" by Leonard SS, Keil D, Mehlman T, Proper S, Shi X, Harris GK.(1)

2. Breast cancer
In the investigation of the effect of Flor-Essence and Essiac (Resperin Canada Limited, Waterloo, Ontario, Canada) a blend of at least four herbs (burdock root [Arctium lappa], Indian rhubarb [Rheum palmatum], sheep sorrel [Rumex acetosella], and the inner bark of slippery elm [Ulmus fulva or U. rubra]) agnaist breast cancer, found that Flor-Essence and Essiac herbal tonics at 1%, 2%, 4% and 8% stimulated cell proliferation relative to untreated controls in both estrogen receptor positive (MCF-7 and T47D) and estrogen receptor negative (MDA-MB-231 and MDA-MB-436) cell lines. Exposure to the tonics also produced a dose-dependent increase in ER dependent luciferase activity in MCF-7 cells. A 10(-7) M concentration of ICI 182,780 inhibited the induction of ER dependent luciferase activity by Flor-Essence and Essiac, but did not affect cell proliferation, according to "Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells" by Kulp KS, Montgomery JL, Nelson DO, Cutter B, Latham ER, Shattuck DL, Klotz DM, Bennett LM.(2)

3. Inflammatory bowel disease
In the investigation of herbal remedies used by patients for treatment of inflammatory bowel disease include slippery elm, fenugreek, devil's claw, found that all six herbal remedies have antioxidant effects. Fenugreek is not a superoxide scavenger, while Mexican yam did not inhibit radical generation by inflamed biopsies. Slippery elm, fenugreek, devil's claw, tormentil and wei tong ning merit formal evaluation as novel therapies in inflammatory bowel disease, according to "Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study" by Langmead L, Dawson C, Hawkins C, Banna N, Loo S, Rampton DS.(3)

4. Inflammatory conditions
In the evaluation fo Hybrid protocols combine one, two, or three pharmaceutical drugs with several nutritional or immune-based therapies, indicated that the goal is to obtain the benefits of protease inhibitors without viral resistance and side effects which include problems with fat metabolism and cholesterol levels. Natural treatments for inflammatory conditions are also described. Options include licorice root, ginger root, and slippery elm, accoridng to "Hybrid protocols plus natural treatments for inflammatory conditions" by [No authors listed](4)

5. Prostate cancer
In the determination of Essiac is a popular complementary and alternative medicine (CAM) that is utilized by many cancer patients in North America, reported that at low doses of Essiac, augmentation of proliferation of these T cells was demonstrated, but at higher doses Essiac was inhibitory to T-cell proliferation. The same doses of Essiac that stimulated spleen cells were inhibitory for LNCaP cell proliferation and concluded that Essiac preparations may be able to inhibit tumor cell growth while enhancing immune response to antigenic stimulation. This may be especially valuable in immune-suppressed individuals.according to "Inhibition of prostate cancer-cell proliferation by Essiac" by Ottenweller J, Putt K, Blumenthal EJ, Dhawale S, Dhawale SW.(5)


6. Diseases prevention
In the evaluation of the activity of Essiac's anti-oxidant, fibrinolytic, anti-microbial, anti-inflammatory, immune modulation, cell-specific cytotoxicity, and impact on cytochrome P450 (CYP450) enzyme pathways. found that Essiac exhibited significant antioxidant activity in the ABTS assay. A 20-fold dilution of Essiac also exhibited significant immunomodulatory effects, specifically through stimulation of granulocyte phagocytosis, increases in CD8+ cell activation, and moderately inhibiting inflammatory pathways. Essiac exhibited significant cell-specific cytotoxicity towards ovarian epithelial carcinoma cells (A2780). Importantly, a 20-fold dilution of Essiac showed significant inhibition of several CYP450 enzymes, most notably CYP1A2 (37%) and CYP2C19 (24%). Essiac demonstrated dose-dependent inhibition of clot fibrinolysis., according to "In vitro analysis of the herbal compound Essiac" by Seely D, Kennedy DA, Myers SP, Cheras PA, Lin D, Li R, Cattley T, Brent PA, Mills E, Leonard BJ.(6)

7. Etc.

Side Effects
1. Slippery elm can interact with other herbs and medication, please consult with your doctor if you are currently taking prescription medicine before consuming slippery elm.
2. Do not use the herb in new born, children or if you are pregnant or breast feeding without approval from the related field specialist
3. Etc.

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Chinese Medicine Herbal Therapy - Popular Chinese Herbs - Ma Ren or Huo Ma Ren (Semen Cannabis Sativae)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                 
          Ma Ren or Huo Ma Ren (Semen Cannabis Sativae)



Ma Ren or Huo Ma Ren is also known as hemp seed. The sweet and neutral herb has been used in TCM to treat constipation, acute infection of urinary tract, rheumatoid arthritis, diarrhea, irregular menses, etc., as it moistens the Intestines, promotes bowel movement, etc., by enhancing the functions of spleen, stomach, large intestine channels..

Ingredients
1. Dietary fiber
2. Fat
3. Saturated fat
4. Palmitic
5. Stearic
6. Monounsaturated fat
7. Oleic
8. Polyunsaturated fat
9. Linoleic
10. Linolenic
11. Gamma-Linolenic
12. Etc.

Health Benefits
1. Antidepressant-like effect
In the assessment of the antidepressant-like activity of Delta(9)-THC and other cannabinoids showed that Delta(9)-THC exhibited the same U-shaped dose response with significant antidepressant-like action at 2.5 mg/kg (p<0.05) while CBC resulted in a significant dose-dependent decrease in immobility at 40 and 80 mg/kg doses (p<0.01). Results of this study show that Delta(9)-THC and other cannabinoids exert antidepressant-like actions, and thus may contribute to the overall mood-elevating properties of cannabis, according to “Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.” by El-Alfy AT, Ivey K, Robinson K, Ahmed S, Radwan M, Slade D, Khan I, ElSohly M, Ross S.(1).

2. Atherogenesis and contractile function
In the determination of if determine if hempseed ingestion over an 8-week period may provide protection to rabbits against the deleterious effects associated with dietary cholesterol supplementation, revealed that dietary hempseed provides mildly beneficial effects against contractile dysfunction associated with atherosclerotic vessels in the cholesterol-fed rabbit, according to “The effect of dietary hempseed on atherogenesis and contractile function in aortae from hypercholesterolemic rabbits” by Gavel NT, Edel AL, Bassett CM, Weber AM, Merchant M, Rodriguez-Leyva D, Pierce GN.(2).

3. Complications of menopause
In the determination of the effects of hamp seed in protect ing against complications of menopause, suggest that hempseed may improve post-ovariectomy complications in rats, according to “The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause” by Saberivand A, Karimi I, Becker LA, Moghaddam A, Azizi-Mahmoodjigh S, Yousefi M, Zavareh S.(3).

4. Functional constipation
In the assessment with a rigidly designed studyof the efficacy and safety of a CHM proprietary medicine, Hemp Seed Pill (HSP), in optimal dosage for treating FC, found that The dose of 7.5 g b.i.d. showed better therapeutic effect than that of 2.5 and 5.0 g b.i.d. among 96 subjects (32 per arm) in trial I and was therefore selected for comparison with placebo in trial II. In trial II, 120 subjects were randomized into two arms (60 per arm). Responder rates for the HSP and placebo groups were 43.3 and 8.3% during treatment and 30.0 and 15.0% in the follow-up period, respectively (P<0.05), according to “Efficacy of a Chinese herbal proprietary medicine (Hemp Seed Pill) for functional constipation” by Cheng CW, Bian ZX, Zhu LX, Wu JC, Sung JJ.(4).

5. Anti-neoplastic chemotherapy, nausea, vomitting and analgesic effects
In the review of the use of traditional medicine and the identification of Delta-9-tetrahydrocannabinol and the cloning of two receptors; CB1 that is primarily present in the central nervous system, and CB2 that is present on the cells of the immune system,
found that The effectiveness of the cannabinoids in the treatment of nausea and vomit due to anti-neoplastic chemotherapy and in the wasting-syndrome during AIDS is recognized. Moreover, the cannabinoids are analgesic, and their activity is comparable to the weak opioids. Furthermore, parallels exist between opioid and cannabinoid receptors, and evidence is accumulating that the two systems sometimes may operate synergistically. The interest of the pharmaceutical companies led to the production of various drugs, whether synthetic or natural derived. The good ratio between the polyunsatured fatty acids omega-3 and omega-6 of the oil of Cannabis seeds led to reduction of the phlogosis and an improvement of the pain symptoms in patients with chronic musculo-skeletal inflammation, according to “[Cannabinoids in the control of pain].[Article in Italian]” by Shaladi AM, Crestani F, Tartari S, Piva B.(5).

6. Immunomodulation effect and anti fatigue
In the study of the effects of Hemp seeds protein (HSP) on antifatigue and immunnomodulation effect in mice, revealed that HSP could have the ability of antifatigue and improve the immunomodulation effect in mice, according to“[Initial study of Hemp seeds protein on antifatigue and the immunomodulation effects in mice].[Article in Chinese]“ by Li Y, Yang R, Hu X, Long Z, et al.(6).

7. Hypercholesterolemia
In the valuation of whether dietary hempseed, a rich source of PUFAs, inhibits platelet aggregation under normal and hypercholesterolemic conditions, showed that when hempseed is added to a cholesterol-enriched diet, cholesterol-induced platelet aggregation returns to control levels. This normalization is not due to a reduction in plasma cholesterol levels, but may be partly due to increased levels of plasma GLA, according to “Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched diet” by Prociuk MA, Edel AL, Richard MN, Gavel NT, Ander BP, Dupasquier CM, Pierce GN.(7).

8. Etc.

Side effects
1. Overdoses and prolonged period of use can damage circulation and cause impotence
2. Do not use the herb in newborn, children or if you are pregnant or breast feeding without consulting first with the related field specialist
3. Overdoses can also cause caused nausea, vomiting, diarrhea, numbness in the limbs, antsy and anxiety, confusion.
4. Etc.



Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20332000
(2) http://www.ncbi.nlm.nih.gov/pubmed/21893466
(3) http://www.ncbi.nlm.nih.gov/pubmed/21069097
(4) http://www.ncbi.nlm.nih.gov/pubmed/21045817
(5) http://www.ncbi.nlm.nih.gov/pubmed/19388223
(6) http://www.ncbi.nlm.nih.gov/pubmed/18589601
(7) http://www.ncbi.nlm.nih.gov/pubmed/18418423

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Most Common Diseases of Ages of 50 Plus: Prostate Cancer - The Diagnosis and tests

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Among elderly men, cancer of the prostate (451 per 100,000), the lung (449 per 100,000) and the colon (176 per 100,000) make up around half of all diagnosed cancers. Prostate cancer is around 22 times more frequent among elderly men than among younger men. The corresponding most frequent cancers among elderly women, making up 48% of all malignant cancers, are breast (248 per 100,000), colon (133 per 100,000), lung (118 per 100,000) and stomach cancer (75 per 100,000), According to the Danish Cancer Society, Institute of Cancer Epidemiology(PubMed)

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.

                             Prostate Cancer

Prostate warped around the around a tube (the urethra) is a gland of the male reproductive system found in front of the rectum and just below the bladder and responsible for making some of semen that carries sperm.


Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.



                             Diagnosis and tests

A. Blood tests
1. Digital Rectal Examination (DRE)
Digital rectal examination is included of physical exam, if you have some of the above symptoms or during an general exam. In DRE, your doctor inserts a lubricated, gloved finger into the rectum to feel the surface of the prostate gland to check for any abnormality of prostate.

2. Trans rectal Ultrasound (TRUS)
Ultrasound allows your doctor to visualize and assess the size of your prostate and to check for any abnormality and surrounding area with image taken from the test. In transcrectal ultrasound, a probe is inserted into the rectum to emit ultrasonic impulses against the prostate.

3. Prostate-specific antigen (PSA) test
The test is to measure the levels of rostate-specific antigen (PSA), a protein produced by the prostate. The high levels of PSA may be a indication of higher risk of the presence of prostate cancer.

4. Prostatic Acid Phosphatase (PAP) test
Prostatic acid phosphatase (PAP) is a test to measure the level of prostatic acid phosphatase, an enzyme produced by the prostate. The higher the levels of PAP is an indication of the disease progression.


B. Prostate biopsy

In prostate biopsy, samples of prostate are taken by a thin, tube-like instrument to examine under microscopy to review the stage of the cancer.

C. Bone scan
It is a nuclear scanning test, beside mostly used in identifying new areas of bone growth and damage to the bones breakdown, it can also evaluates the metastasis (spread) of cancer in the bone, if you doctor suspected that the prostate cancer has been spreading to the bone.

D. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health


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Dietary Minerals Calcium: Calcium and S100 proteins

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                 Dietary Minerals 

Dietary Minerals are the group of minerals which is essential for our body to sustain normal functions and physical health.

                                      Calcium

Calcium, a trace mineral plays an important role in build and maintain strong bones and teeth, found abundantly in meat, poultry, fish, nut, seeds, bean, etc. As we age, calcium is absorbed less effectively.

      Calcium and S100 proteins


S100 proteins play a crucial role in multiple important biological processes in vertebrateorganisms acting predominantly as calcium signal transmitters.According to the study by the Polish Academy of Sciences, after four Ca(2+) ions bind, it undergoes a dramatic conformational change, resulting in exposure, in each of its two identical subunits, a large hydrophobic cleft that binds to target proteins. It has been shown that abnormal expression of S100A1 is strongly correlated with a number of severe human diseases: cardiomyopathy and neurodegenerative disorders(8).

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Women Health: The Obesity and Polycystic ovary syndrome Research and Studies of Procalcitonin (PCT) and Obesity polycystic ovary syndrome (PCOS)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

Polycystic Ovarian Syndrome is defined as endocrinologic diseases caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries as resulting of enlarged ovaries, leading to hormone imbalance( excessive androgen), resulting in male pattern hair development, acne,irregular period or absence of period, weight gain and effecting fertility. It effects over 5% of women population or 1 in 20 women.

The Studies of  Procalcitonin (PCT) and Obesity polycystic ovary syndrome (PCOS)

Procalcitonin (PCT) is a potential biomarker of obesity-related, low-grade inflammation in polycystic ovary syndrome (PCOS). In the study to to investigate whether serum procalcitonin, high-sensitivity C-reactive protein (hs-CRP), white blood cell (WBC) and neutrophil counts are associated with polycystic ovary syndrome and with obesity, posted in PubNMed, found that PCOS patients had significantly higher levels of serum PCT, hs-CRP, WBC, and neutrophil counts than healthy women. In control and PCOS groups, serum PCT, hs-CRP levels, WBC, and neutrophil counts were significantly increased in overweight and obese women compared with lean subjects. Serum PCT levels were positively correlated with BMI, waist/hip ratio, total cholesterol, serum triglycerides, LH/FSH, hs-CRP values, WBC and neutrophil counts in PCOS women. The increasing obesity was accompanied by a significant increase in the mean values of serum PCT and neutrophil counts in PCOS patients.
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Women Health: Menstrual Disorders -Menorrhagia - The Preventive Nutritional Supplements

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Menorrhagia is defined as a condition of excessive bleeding in the menstruation phase of the menstrual cycle in the reproductive age of a woman leading to heavy blood loss that can interfere with the woman normal activities, as a result of disruption of normal hormonal regulation of periods or disorders of certain reproductive organs.


                          The Diagnosis 
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Phytochemicals for Treatment of Hodgkin's lymphoma

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Food intake can help to prevent and treat cancers.


             Hodgkin's Lymphoma

Hodgkin's Lymphoma, a type of lymphoma is also known as Hodgkin's Disease started from the lymph nodes in the chest, armpits and neck. It was named under Thomas Hodgkin, for first to describe the abnormalities of the lymph system in 1832. Hodgkin's lyphoma, is invasive and tends to spread orderly from one lymph node group to another. It is not a common disease with approximately 800 and 7000 of new cases reported every year in Canada and US accordingly and mostly occurs to young adults and after the age of 45.

II. Types of Hodgkin's lymphoma
1. Nodular sclerosis Hodgkin's Lymphoma's (NSHD)
It is the most common type of Hodgkin's lymphoma, accounted for 60% to 80% of all cases originated from the lymph nodes of the chest, including the upper diaphragm and abdominal muscles that control breathing just under the lung.

2. Mixed cellularity Hodgkin's lymphoma (MCHD)
It is another type of Hodgkin's lymphma, accounted for 15 - 30% of all cases and tends to affect the lymph nodes of the abdomen, the neck and armpits and men than women with all ages.

3. Lymphocyte depletion Hodgkin's lymphoma (LDHD)
It is a rare type of Hodgkin's lymphoma accounted less than 1% of all cases and occurred more often in the undeveloped world. Most of the time it is detected without enlarged lymph nodes in the neck, armpits or groin. The disease is classified to 2 subtypes
a. Nodular lymphocyte predominant Hodgkin's lymphoma (nLPHD)
b. Diffuse lymphocyte predominant Hodgkin's lymphoma (dLPHD)

4. Lymphocyte-rich classic Hodgkin's lymphoma (cLRHD)
It is also another rare type of Hodgkin's lymphoma, accounted for approximate for 5% of all cases and tends to occur in the age group of 45+ years of age and more in men than women. It is most common to be detected with an enlargement of lymph nodes in the neck, chest or armpits, other lymph nodes and organs.

5. Etc.

III. Types of Food to Prevent and Treat Hodgkin's lymphoma
1. Turmeric
Turmeric, a principal curcuminoid of the popular Indian spice, a rhizomatousherbaceous perennial plant of the ginger family, Zingiberaceae, native to tropicalSouth Asia, according to "Effects of different drying methods on the antioxidant properties of leaves and tea of ginger species" by E.W.C. Chan, Y.Y. Lim, S.K. Wong, K.K. Lim, S.P. Tan, F.S. Lianto and M.Y. Yong, posted in Science Direct. It has been used in traditional herbal medicine as an anti-inflammatory agent and to treat gastrointestinal symptoms associated with irritable bowel syndrome and other digestive disorders. Curcumin is a phytochemical found abundant in the plant. In acidic solutions (pH <7.4) it turns yellow, whereas in basic (pH > 8.6) solutions it turns bright red. In the study to to find new therapies that specifically target the deregulated signaling cascades, such as NF-kappaB and STAT3, which causeHodgkin and Reed-Sternberg (H-RS) cell proliferation and resistance of apoptosis, indicated that Curcumin is incorporated into H-RS cells and acts inhibiting both NF-kappaB and STAT3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1, survivin, c-myc and cyclin D1. Interestingly, curcumin caused cell cycle arrest in G2-M and a significant reduction (80-97%) in H-RS cell viability. Furthermore, curcumin triggered cell death by apoptosis, as evidenced by the activation of caspase-3 and caspase-9, changes in nuclear morphology and phosphatidylserine translocation. The above findings provide a mechanistic rationale for the potential use of curcumin as a therapeutic agent for patients with HL(1).

2. Legumes
Genistein, a phytochemical in the Isoflavones, found abundantly in Legumes, has exerted protective effects against Hodgkin's Lymphoma. In the study to investigate genistein's inhibitory effect on the growth of acute lymphoblastic leukemia (RS4;11 and CEM), lymphoma (Toledo and GA10) and multiple myeloma (OPM-2 and U266) cell lines in vitro, indicated that The mechanism of growth inhibition was through induction of apoptosis and cell cycle arrest. The concomitant altered expression of apoptosis pathway proteins and cell cycle modulators (caspases 9, 3, 7, PARP [poly(ADP-ribose) polymerase], cIAP1 [inhibitor of apoptosis protein 1], Bcl-2 and cyclin B1) were observed by Western blot and real-time polymerase chain reaction (PCR) analyses. In addition, some malignancy-related embryologic pathway proteins, e.g. Notch1 and Gli1, were modulated by genistein treatment in sensitive cell lines(2).

3. Green tea
Epigallocatechin-3-gallate (EGCG), a phytochemicals found abundantly in green tea has enhanced the protective effects against Lymphoma. Dr, Yu AF, and scientists at the Fujian Medical University,in the study of [Demethylation and transcription of p16 gene in malignant lymphoma cell line CA46 induced byEGCG], found that after treatment with EGCG for 48 hours, the methylation level was apparently attenuated in a concentration-dependent manner. Expression of p16 gene in untreated group was mild while in the treated groups it had been greatly strengthened, as compared with untreated group, the gray scale ratio of p16 to beta-actin 1 treated with EGCG (6, 12, 24) microg/ml was increased from (0.05 +/- 0. 01) to (0.19 +/- 0.03), (0.39 +/- 0.10), (0.85 +/- 0.09) respectively, exhibiting a significant difference (p < 0.05); as compared with the untreated group, after treatment with EGCG for 48 hours, the expressions of DNMT3A and DNMT3B were obviously down-regulated. It is concluded that EGCG can activate and up-regulate the expression of p16 gene mRNA which inhibits the proliferation of CA46 cell through inducing the G(0)/G(1) arrest by demethylation and/or by inhibiting DNMT3A and DNMT3B gene(3).

4. Grape skin and red wine
In the study to explore the effect of resveratrol on B-cell leukemia/lymphoma-2 (Bcl-2) and vascular endothelial growth factor (VEGF) expression in rats with oxygen-induced retinopathy of prematurity (ROP), found that Resveratrol can significantly inhibit expression of Bcl-2 and VEGF in the retina of neonatal rats with oxygen-induced ROP. It may provide a protective effect on retinal neovascular diseases, including ROP(4).

5. Deep sea fish
Dr. Finstad HS, and the research team at University of Oslo, found that the monocytic cell line U937-1 was cultured in the presence of eicosapentaenoic acid(20:5, n-3) (EPA) or oleic acid (18:1, n-9) (OA). EPA caused a dose-dependent inhibition of cell proliferation, whereas OA had no effect. At the highest EPAconcentrations, 120 and 240 microM, inhibition of cell proliferation was accompanied by initiation of apoptosis(5).

6. Garlic
In the study to investigate increased garlic (Allium sativum) consumption with a reduced incidence of cancer in various human populations, indicated that allicin inhibited the growth of tumor cells at doses two fold superior to that in normal splenocytes. Allicin also induced apoptosis, and this was associated with an increase in caspase3 activity(6).

7. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health


Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/18386790
(2) http://www.ncbi.nlm.nih.gov/pubmed/21749310
(3) http://www.ncbi.nlm.nih.gov/pubmed/18928598
(4) http://www.ncbi.nlm.nih.gov/pubmed/22148982
(5) http://www.ncbi.nlm.nih.gov/pubmed/9820824
(6) http://www.ncbi.nlm.nih.gov/pubmed/21198270

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