Medical Advisor Journals

Friday, September 9, 2016

Phytochemicals for Treatment of Pancreatic Cancer (Exocrine Cancers)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Food intake can help to prevent and treat cancers.

Pancreatic Cancer (Exocrine Cancers)

Cancer of pancreas or pancreatic cancer is defined as condition of a malignantneoplasm of the pancreas, as the cells have become cancerous and divided uncontrollably. Most pancreatic cancers start in the ducts (exocrine component of the pancreas) that carry pancreatic juices with cancer of an epithelium that originates in glandular tissue accounts for over 75 - 90% of all cases of exocrine cancers.

Types of food to prevent and treat pancreatic cancer
1. Pomegranate
Pomegranate extract (PE) is a standardized whole-fruit extract of pomegranate, a fruit with known anticancer properties, Dr. Nair V, and the research team at the University of Texas at Austin, in the study ofPomegranate extract induces cell cycle arrest and alters cellular phenotype of human pancreatic cancer cells, showed that PE treatment induced cell cycle arrest and inhibited cell proliferation in PANC-1 cells. PE treatment increased the proportion of cells lacking CD44 and CD24 expression, which are associated with increased tumor-initiating ability, demonstrating that PE altered cell phenotype. PE was more effective in inhibiting the proliferation of PANC-1 cells than the clinically used dose of paclitaxel. Similar results were obtained in the AsPC-1 cell line. Individual pomegranatephytochemicals were only modestly effective in inhibiting cell proliferation(1).

2. Curcumin, raspberry and neem leaf
the study of Impact of curcumin, raspberry extract, and neem leaf extract on rel protein-regulated cell death/radiosensitization in pancreatic cancer cells showed that CUR, NLE, and RSE may serve as effective "deliverables" to potentiate RT in PC cure and further throw light that these phytochemicals-induced cell killing may involve selective regulation of RT-induced NF-κB(2).

3. Tomato
Lycotene is a phytochemical compound and bright red pigment belonging to group of carotene in the family of carotenoids found mostly in tomatoes. In the study to investigate the possible association between dietary carotenoids and pancreatic cancer risk. A case-control study of 462 histologically confirmed pancreatic cancercases and 4721 population-based controls in 8 Canadian provinces took place between 1994 and 1997, showed that After adjustment for age, province, BMI, smoking, educational attainment, dietary folate, and total energy intake, lycopene, provided mainly by tomatoes, was associated with a 31% reduction in pancreatic cancer risk among men [odds ratio (OR) = 0.69; 95% CI: 0.46-0.96; P = 0.026 for trend] when comparing the highest and lowest quartiles of intake. Both beta-carotene (OR = 0.57; 95% CI: 0.32-0.99; P = 0.016 for trend) and total carotenoids (OR = 0.58; 95% CI: 0.34-1.00; P = 0.02 for trend) were associated with a significantly reduced risk among those who never smoked. The results of this study suggest that a diet rich in tomatoes and tomato-based products with high lycopene content may help reduce pancreatic cancer risk(3).

4. Grapes and berries
Myricetin, a flavonol, belong to the flavonoid in Flavonoids (polyphenols), found in many grapes, berries, etc. has been used as antioxidant to lower cholesterol, treat certain types of cancer, etc. In the observation of the flavonoid myricetin and its effect on metastatic pancreatic cancer cell lines, found that myricetin resulted in tumor regression and decreased metastatic spread. Importantly, myricetin was non-toxic, both in vitro and in vivo, underscoring its use as a therapeutic agent against pancreatic cancer, according to the study of "Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway" by Phillips PA, Sangwan V, Borja-Cacho D, Dudeja V, Vickers SM, Saluja AK.(4)

5. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease,
particular in treatment of menstrual disorder in Women Health

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21868510
(2) http://www.ncbi.nlm.nih.gov/pubmed/21697760
(2) http://www.ncbi.nlm.nih.gov/pubmed/15735099
(4) ) http://www.ncbi.nlm.nih.gov/pubmed/21676539

Women Health: Menstrual Disorders - Oligomenorrhea Prevention: Nutritional supplements

The Preventive Nutritional supplements

1. Iron
Iron is essential for women suffering from menorrhagia. Since excessive bleeding causes the loss of iron causing iron deficiency, without enough iron our body cannot reproduce red blood cells to replace those lost in bleeding resulting in symptoms of paller, weakness, fatigue as well as increasing the risk of inflammation.

2. Vitamin B complex
Vitamin B complex is a liver tonic vitamin. It helps the liver to convert the bad estrogen, xanooestrogen into weaker and less dangerous forms and converts omega 6 oils into a form that can be used by the body to produce the good type prostaglandins instead of dinoprostone resulting in reduced menstrual cramps and pain.

3. Cod liver oil
Cod liver oil contains high amounts of omega 3 fatty acids that control heavy bleeding during periods. Since red meat and dairy products contain arachidonic acid without balancing intake of omega 3 fatty acid, this causes the over production of dinoprostone leading to increased blood flow, and reducing blood-clotting ability.

4. Zinc
Besides having an important role in treating enlarged prostate in men's health, this mineral is vital for the healthy functioning of the reproductive system in women as well as maintaining hormone balancing.

5. Flavonoid
Flavonoid is a powerful antioxidant activity. It helps to protect small blood vessels from damage resulting in protecting against the blood loss of menorrhagia during menstruation.

6.Vitamin A
Vitamin A is an antioxidant. It works together with iron and copper to help enhance the production of red blood cells. Vitamin A deficiency has been found in women with menorrhagia.

7. Vitamin C
Besides being an antioxidant that helps our body to fight against free radicals from building up and the digestive system's metabolism to reduce menstrual pain.

8. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease,
particular in treatment of menstrual disorder in Women Health

General Health: Cystitis - The Causes

Cystitis

Cystitis is defined as a condition of urinary bladder inflammation

The Causes

1. Bacterial infection
Streptococcus agalactiae or group B streptococcus is a Gram-positive pathogen that is typically associated with neonatal disease and infection in pregnant women. Group B streptococcus also causes invasive infections in non-pregnant adults including urinary tract infections(5). Other researchers found that in 85.7% of cases following non-clostridial anaerobic (NCA) bacteria were identified in biopsy samples: Propionibacterium sp. (41.8%), Peptococcus sp. (35.7%), Eubacterium sp. (28.6%), Peptostreptococcus sp. (14.3%), and Bacteroides sp. (14.3%). Aerobic-anaerobic associations were observed in 7.1% of samples(6).

2. Nonbacterial infection
a. Viral cystitis
BK-virus is a very common polyomavirus in the global population, similar to the JC-virus responsible for Progressive Multifocal Leukoencephalopathy. BK-virusinfections are an important diagnostic and therapeutic challenge in immuno-compromised patients, including: bone marrow transplant pediatric recipients in whom it may cause hemorrhagic cystitis(7).

b. Mycobacterial infection
There is a review of a to review clinical features, diagnosis and treatment of renal mycobacteriosis, illustrated by presentation of a case of pyelonephritis and cystitiscaused by Mycobacterium chelonei(8).

c. Chlamydial infection
In the study of Male guinea pigs infected with the chlamydial agent of guinea pig inclusion conjunctivitis (GPIC) by intraurethral injection of chlamydiae or by placement of a drop of chlamydial suspension on the meatus of the extruded penis, researchers found that when infected animals were immunosuppressed with cyclophosphamide, the number of guinea pigs with cystitis was increased, and chlamydiae could be detected in the bladder for as long as 50 days afterinfection(9).

d. Fungal infection
There is a report of 4 cases of fungal cystitis. All patients had severe urgency, frequency and nocturia with sterile pyuria and microhematuria. Significant fungalgrowth was observed on routine blood agar cultur. Bladder biopsy was necessary to rule out tumor(10).

e. Schistosomal infection
In the study to evaluate the immunoreactivity for p53 and c-erbB-2 proteins in 31schistosomal urinary bladder carcinomas and 21 cases of schistosomal cystitiswith hyperplastic, metaplastic and/or dysplastic (premalignant) lesions and compare with 30 carcinomas and 21 premalignant lesions of the urinary bladder without schistosomiasis showed that abnormal nuclear p53 protein accumulation was found in 17/31 schistosomal and in 15/30 non-schistosomal carcinomas and in 8/21 schistosomal cystitis with premalignant lesions of which five showed hyperplasia(11).

f. Etc.

3. Noninfection and Bladder syndrome/interstitial cystitis (PBS/IC)
In the study to describe the practice patterns among primary care physicians' (PCPs) managing patients with symptoms suggestive of interstitial cystitis/painful bladder syndrome (IC/PBS), indicated that of 290 completed questionnaires (response rate, 52%), regarding etiology, 90% correctly indicated that IC/PBS was a noninfectious disease((radiation cystitis, autoimmune, hypersensitivity), 76% correctly reported that it was not caused by a sexually transmitted infection, and 61% correctly indicated that it was not caused by a psychiatric illness(12).

Chinese Food Therapy
The Best Way to prevent, treat your disease,
particular in treatment of menstrual disorder in Women Health

Chinese Medicine Herbal Therapy - Popular Chinese Herbs -Mu Dan Pi or Dan Pi (Cortex Moutan Radicis)

Mu Dan Pi or Dan Pi (Cortex Moutan Radicis)

Mu Dan Pi or Dan Pi (Cortex Moutan Radicis) is also known as peony root. The acrid, bitter and mild cool herb has been used in TCM as anti micro organism, anti inflammatory agent and to enhance circulation and immune system, etc., as it clears heat and cools the blood, clears fire of yin deficiency, clear blood stasis and rid of clots, etc., by enhancing the functions of heart, liver and kidney channels.

Ingredients
1. paeonol
2. paeonoside
3. paeonolide
4. apiopaeonoside
5. ozypaeoniflorin
6. benzoylpaeoniflorin
7. benzoyl-oxypaeoniflorin
8. gallic aid
9. 1,23,4,6-pentagalloylglucose
10. Etc.

Health Benefits
1. Arthritis
In the comparison of the anti-arthritis effect and its mechanism of a combination of herbal extracts from Trachelospermi caulis (TC) and Moutan cortex radicis (MC) (TCMC), indicated that TCMC exerts an anti-arthritis effect in CIA mice by suppression of the production of various inflammatory factors and the formation of osteoclasts through the inhibition of NF-κB and AP-1 activation(1).

2. Anti-inflammatory and anticoagulative effects
In the study to investigate Paeonol, n active component of Moutan Cortex Radicis and is widely used as an analgesic, antipyretic, and anti-inflammatory agent in traditional Chinese medicine, found that paeonol successfully attenuates inflammatory and coagulation reactions to protect against acute lung injury (ALI)(2).

3. Asthma
In the study to determine whether Moutan Cortex Radicis (MCR), a plant extract, effects eotaxin secretion from A549 epithelial cells and eosinophil chemotaxis, and then examined the mechanism involved, indicated thatsuppressed eotaxin secretion by MCR treatment is due to the inhibition of NF-kappaB activation. Therefore, MCR might be of therapeutic value in treating asthma(3).

4. Anti-microbial and cytokine modulating effects
In the study of antimicrobial and cytokine modulating effects of herbal medicines in treating periodontal diseases, using the broth dilution method and disc agar diffusion test, in individual and combined decocted preparations, different concentrations of Ching-Wei-San and its individual herbal components, Coptidis rhizoma, Angelicae sinensis radix, Rehmanniae radixet rhizom, Moutan radicis cortex, and Cimicifuga foetida, were tested for in vitro inhibitory effects on three well-known plaque-causing bacteria, Porphyromonas gingivialis, Streptococcus sanguis, and Streptococcus mutans, and two common pathogens, Staphylococcus aureus and Escherichia coli, showed that Ching-Wei-San at the 25,000 mg/mL concentration daily for the mice had significantly high levels in the liver function indexes in the 3-day acute toxicity test and in both the liver and kidney function indexes in the 28-day subacute toxicity test (P<0.01). The 250 mg/mL Ching-Wei-San is comparable to 250 mg/mL of tetracycline, and had similar inhibitory effects on the tested bacteria. Coptidis rhizoma (62.5 mg/mL) was the only individual herbal component to show 100% inhibitory effects. The mean cytokine ratios of IL-2, IL-4, IFN-gamma, and TNF-alpha in Balb/c mice treated with individual herbal components were shown to be different from each other. Ching-Wei-San modulated the immunity of mice, up-regulated IL-2, IL-4 and TNF-alpha, but down-regulated IFN-gamma(4).

5. Anti cancers
The investigated the effects of an oriental medicinal prescription, Geiji-Bokryung-Hwan (GBH) consisting of herbs of Cinnamomi Ramulus, Poria Cocos Hoelen (Pachymae Fungus), Moutan Cortex Radicis, Paeoniae Radix, and Persicae Semen, on growth-inhibitory activity and cancer chemopreventive activity in assays representing three major stages of carcinogenesis. The GBH was found to act as an potent inhibitor of cyclooxygenase (COX)-1 only but not as COX-2 inhibitor. Furthermore, the extract mediated anti-inflammatory effects and inhibited COX-associated hydroperoxidase functions (anti-promotion activity). Inhibitory effect of the GBH on the growth of cancer cell lines such as HepG2 cell and Hep3B cell was shown(5).

6. Etc.

Side Effects
1, Do not use the herb in case of excessive menstruation, bleeding due to Yin deficiency
2. Do not use the herb in newborn, children, or if you are pregnant or breast feeding without first consulting with related field specialist
3. Etc.

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Chinese Food Therapy

The Best Way to prevent, treat your disease, including Obesity

and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22309274
(2) http://www.ncbi.nlm.nih.gov/pubmed/22454687
(3) http://www.ncbi.nlm.nih.gov/pubmed/17881168
(4) http://www.ncbi.nlm.nih.gov/pubmed/16962225
(5) http://www.ncbi.nlm.nih.gov/pubmed/16237957

General Health: Infectious colitis - Treatments in Conventional medicine

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Colitis

Colitis is defined as a condition of inflammation of the large intestine, including the colon, caecum and rectum.

Types of Colitis

According to the study by Catholic University of the Sacred Heart, types of colitis include
microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis and Behcet's colitis(a).

The Infectious colitis - Treatments

Clostridium difficile, atypes of infectous colitis, has become an increasingly important nosocomial pathogen and is one of the most common causes of hospital-acquired diarrhea. The incidence of C difficile infection (CDI) is increasing worldwide(97a).
A.5.1. Non surgical therapy
1. Antimotility therapy
If patients are expereince with diarrhea of small bowel origin, then Antimotility therapy can be helpful. According to the study by the Service de Médecine B Centre hospitalier universitaire de l'hôpital d'adultes, although effective therapy is not available for patients with enteric viruses, Cryptosporidium, and Microsporidium, therapy is useful for children with amebiasis, antimicrobial-associated colitis, cholera, giardiasis, various forms of Escherichia coli diarrhea and Salmonella disease, isosporiasis, shigellosis, and strongyloidiasis(98).

2. Probotic
Perturbation of bacterial microflora of the gastrointestinal (GI) tract may play an important role in the pathophysiology of some GI disorders. Probiotics have been used as a treatment modality for over a century. They may restore normal bacterial microflora and effect the functioning of the GI tract by a variety of mechanisms. According to the study by Columbia University College of Physicians and Surgeons, the efficacy of probiotics, either as a single strain or a combination of probiotics, has been tested in antibiotic-associated diarrhea, Clostridium difficile colitis, infectious diarrhea, ulcerative colitis, Crohn's disease, pouchitis, and irritable bowel syndrome, among other disorders. Results of the studies are reviewed in this article and recommendations for probiotic use in these disorders are made. Although probiotics appear to be generally safe in an outpatient setting, the situation may be different in immunocompromised, hospitalized patients who may be at a greater risk of developing probiotic sepsis(99).

3. Other treatments
In the study to review and to investigate the efficacy of antibiotic therapy for C. difficile-associated diarrhea (CDAD), conducted by Northern General Hospital, indicated that the studies provide little evidence for antibiotic treatment of severe CDAD as many studies excluded these patients. A recommendation to achieve these goals cannot be made because of the small numbers of patients in the included studies and the high risk of bias in these studies, especially related to dropouts. Most of the active comparator studies found no statistically significant difference in efficacy between vancomycin and other antibiotics includingmetronidazole, fusidic acid, nitazoxanide or rifaximin. Teicoplanin may be an attractive choice but for its limited availability (Teicoplanin is not available in the USA) and great cost relative to the other options. More research of antibiotic treatment and other treatment modalities of CDAD is required(100).
Other researcher indicated that treatment of Clostridium difficile CDI is challenging due to the limited number of drugs that have proven to be effective, concerns about antibiotic resistance, and recurring disease. The recent approval of fidaxomicin provides a new alternative. Immune therapy will likely play a greater role in the future(101).

A.5.2. Surgical treatment
Sugical treatment may be necessary for patients with microscopic colitis if patients are not respond to medication treatment, depending to the patients conditions.
In the study of sixty-seven patients (mean age, 69 (range, 40-86) years; 99 percent males) were identified. All 67 patients had C. difficile verified in thecolectomy specimens, found that twenty-six of 67 patients (39 percent) underwentcolonoscopy; all 26 were found to have severe inflammation or pseudomembranes. Fifty-three of 67 patients (80 percent) underwent totalcolectomy; 14 of 67 underwent segmental colonic resection. Perforation and infarction were found in 59 of 67 patients (58 percent) at surgery. Overall mortality was 48 percent (32/67). Mean hospitalization was 36 (range, 2-297) days(102). Several recent studies have elucidated factors that contribute to the unacceptably high postoperative mortality rate: Surgical intervention too late in the course of the disease, lack of clearly defined guidelines for patient selection, and difficulty in predicting the clinical course of the disease. Perforation, need for vasopressor support, and end-organ damage all affect the postoperative mortality rate negatively(103).

Children Health: Autism - The Importance of Nutritional Supplements

Autism is one of the most common forms of brain development disorder and one in 166 child is diagnosed with some forms of autism. Children who are diagnosed with autism tend to have weak immune system and auto immune problems. Autism is defined as medical condition in which a child has some of the following impairments
a) Speech
b) Social and communication skills
c) Limited interest
d) Repetitive behaviour

The Importance of Nutritional Supplements

a) Taurine
Taurine is one amino acid which not only helps to calm the brain and inhibits the excitation of nerve cells, it also helps to blocks the excito-toxic effects of glutamate and aspartate, resulting in lessening the risk of extremely hyperactive and regression.

b) Glutamine
It is a precursor to the antioxidant glutathoine. Besides helping to prevent excessive cells oxidation, thus decreasing the risk of abnormal transmitting information of brain cells due to impaired cellular membranes, it also improves the digestive enzyme and probiotics to the gastrointestinal tract, thereby restoring the integrity of the digestive system.

c) Glutathione
Glutathione is found in the liver, it helps the liver to detoxify many harmful compounds through the bile secretion. Beside helping to protect our body against cells oxygen oxidation and increase the neorological function, it also replenishes the gastrointestine tract.

d) Carosine
It is said that carosine helps to enhance neurological function, including behavior, language, eye contact and speech. Studies shows that intake of carosine helps to improve the brain in controlling emotion, epileptic activity, cognitive, expressive speech, and abstract thinking for some children with autism.

e) Melatonin
Melatonin is a type of hormone which is produced by our brain to make us falling to sleep and normally used as sleep aid medicine for children. Since most children with autism having behavior problem, including sleep disturbance, melatonin improves the combination of better sleep, better control of biological rhythms and high anti-oxidant effect. No matter how good, it is, it is still a types of hormone, please consult with the children doctors before applying.

f) DMSA
DMSA is an oral chelating agent that helps to remove mercury and other metals from the body, including toxic heavy metals in the brain, resulting in improvement in social reciprocity for children with autism.

g) Coenzyme Q 10
Coenzyme Q 10 besides is important in maintaining a healthy immune system, it also helps improve the neurological functions by getting more oxygen to the brain and central nervous system, resulting in increasing energy as resulting of of the ATP energy cycle and improving mental alertness.

h) Essential Fatty Acids
Essential fatty acids Omega 3 and Omega 6, besides helping to maintain the normal function of brain cells, and decreasing the cholesterol in the blood stream. it also places an important role in enhancing the attention spans and improving concentration for children with autism. Essential fatty acids Omega 3 and 6 can be found in cold water fish, flax seed oil, olive oil and nuts and seeds.
Chinese Food Therapy
The Best Way to prevent, treat your disease,
particular in treatment of menstrual disorder in Women Health

Overcome Infertility: Hysteroscop of Female Infertility In Conventional medicine Perspective

Infertility is defined as inability of a couple to conceive after 12 months of unprotected sexual intercourse. It effects over 5 millions couple alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seeks help from professional specialist.

Hysteroscop of Female Infertility In Conventional medicine Perspective

Hysteroscopy is a study of infertile women uterine abnormality by endoscopy.

Procedure
The hysteroscope is an medical instrument which is used to exam the infertile woman cavity. It is connected to a video unit with a light source, and to the channels for delivery and removal of a distention medium, the cavity normally is expand by either fluids or CO2 gas during inspection. It normally is done at the hospital as outpatient or in clinical laboratory.

Diagnosis
By placing the hysteroscope through the cervical canal to check the inside of uterus. Your doctor can check for any abnormality in the uterus. If found, sometimes it can be operated right the way with a specialized instruments.

Risk
1. Damage the uterine wall
2. Bleeding
3. Damage to other reproductive organ.