Friday, October 7, 2016

Chinese Herbal Medicine Therapy: Sang Ji Sheng (Ramulus Loranthi)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                 
          Sang Ji Sheng (Ramulus Loranthi)
Sang Ji Sheng is also known as mulberry mistletoes. The bitter and neutral herb has been used in TCM as diuretic, lowering blood pressure, sedative, antiviral agent and to dilate coronary arteries, improve volume of circulation, etc., as it expels Wind-Damp, tonifies the Liver andthe Kidney, strengthens the sinews and bone, prevents miscarriage, etc. by enhancing the functions liver and kidney channels.

Ingredients
1. Quercetin
2. Avicularin
3. Triterpenes
4. Oleanolic acid
5. Flavonoids
6. (+)-catechin; Rutin; Isoquercitrin
7. 7-O-galloyl-(+)-catechin; Quercetin-3-O-(6″-galloyl)-(-D-glucoside
8. Quercetin-3-O-(6″-galloyl)-(-D-galactoside
9. Quercetin-3-O-(-D-glucuronide
10. Etc.

Health Benefits
1. Fatty acid synthase (EC 2.3.1.85, FAS) inhibition and body weight reduction
In the study to determine the inhibitory characteristics and kinetic parameters of extracts of parasitic loranthus [Taxillus chinensis (DC.) Danser]. The parasitic loranthus extracts (PLE) inhibits FAS reversibly and irreversibly and with an IC50 value of 0.48 microg/ml, appears to be the most potent inhibitor reported to date. PLE contains various potent inhibitors and may react with different sites on FAS. The irreversible inhibition exhibits a time-dependent biphasic process including a speedy fast-phase during the initial several minutes. The fast-phase inhibition seems to be caused by some potent but low-concentration component(s) in the extracts(1)
2. Refractory polycystic ovary syndrome (PCOS)
In the clinical effect of traditional Chinese medicine Bushen Houxue (BSHX)(dodder seed 20 g, prepared rehmannia root 10 g, mulberry mistletoe 20 g, epimedium 15 g, psoralea fruit 10 g, solomonseal rhizome 10 g, honeylocust thorn 15 g, peach kernel 10 g, pleione bulbocodioides 10 g, red sage root 20 g, and licorice root 6 g,) method combined with ultrasound-guided follicle aspiration (MFA) in treating refractory polycystic ovary syndrome (PCOS) found that BSHX method combined with MFA is a safe and effective treatment for refractory PCOS, with few trauma. The combined usage of Chinese herbal medicine could significantly reduce dosage of HMG used for promoting follicle and the production of multiple mature follicles, thus to avoid the risk of ovarian hyperstimulating syndrome (OHSS)(2).
3. Anticancer effects
In the study to compare the anticancer effects of flavonoids extracts of Scurrula parasitica from different host trees in vitro. 80% ethanol extracts of S. parasitica parasitizing on Nernium indicum, Morus alba, Opsmanthus fragrans, and Sapindus mulorossi were purified by polyamides column chromatography, and the eluates of 30%, 50%, 70% and 90% ethanol were mixed as flavonoids extracts. Extract of S. parasitica parasitizing on N. indicum (NISPEX) was the most sensitive to HL-60 cells of the 4 different host trees, the IC50 value being 0.60 mg x L(-1); and extract of S. parasitica parasitizing on M. alba took the second place, the IC50 value, being 2.49 mg x L(-1); extract of S. parasitica parasitizing on O. fragrans had no effectiveness as high as 50 mg x L(-1) concentration. NISPEX induced HL-60 cell apoptosis and inhibited the cell proliferation in dose and time-dependent manner. Cell cycles were arrested at G0-G1 phase after treated with NISPEX(3).
4. Diabetes
In the study of the Effects of oral administration of some herbal extracts on food consumption and blood glucose levels in normal and streptozotocin-treated diabetic rats, showed that Tapinanthus nyasicus leaf, Ficus thoningii bark, Solanum incanum fruit, and Morus alba leaf extracts decreased weekly food consumption throughout the 5-week study period. Similar results were obtained for the groups treated with metformin or glibenclamide. However, food consumption was increased by S. incanum root, Aloe chabaudii leaf, or Allium sativum bulb extracts, and this was associated with high prevalence of diarrhea(4).
5. Etc.

Side Effects
1. Overdose can cause vomiting, diarrhea, etc.
2. Etc.
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Chinese Herbal Medicine Therapy: Sang Ye (Folium Mori Albae)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                 
          Sang Ye (Folium Mori Albae)
Sang Ye is also known as White Mulberry Leaf. The bitter, sweet and cold herb has been used in TCM to treat common cold and influenza, dizziness and blurry vision due to liver yang ascending, edema, etc., as it drains Wind, clears Heat and Liver-Heat, improves vision, etc by enhancing the functions of lung and liver channels.

Ingredients
1. Rutin
2. Quercetin
3. Isoquercitrin
4. Morocetin
5. Moracetin，
6. Quercetin-3-Triglucoside
7. Astraglin
8. Inokosterone
9. Ecdysterone
10. β-sitosterol
11. Uumbelliferone
12. Scopolin
13. α-，β-hexenal
14. Etc.

Health Benefits
1. Diabetes mellitus
In the study to a literature review aimed to analyse various studies related to the use of phytotherapy in diabetes mellitus in Turkey in order to provide additional information for healthcare professionals, indicated that among the herbs most-commonly used along with modern medical therapies and also in folkloric medicine, we searched for bitter melon, cinnamon, fenugreek, olive leaf, black seed and white mulberry. Studies conducted in this field have produced conflicting results and, the necessity to conduct randomized, placebo-controlled clinical human studies to develop new drugs from herbs, as in the case of metformin, still remains important. Besides, further studies are required to address the issues of standardization and quality control of existing preparations. More importantly, healthcare professionals caring for diabetic patients need to be aware of phytotherapy to incorporate phytomedicine into their practices and should undertake more responsibility in relation to these kind of therapies that are commonly-used throughout the world(1).
2. Oxidative stress
In the study to investigate the effects of ML in metabolic disorders and examined the mechanisms by which ML ameliorates metabolic disorders in db/db mice, found that ML ameliorates adipocytokine dysregulation at least in part through inhibiting oxidative stress in WAT of db/db mice, and that ML may be a basis for a pharmaceutical for the treatment of the metabolic syndrome as well as reducing adverse effects of pioglitazone(2).
3. Obesity or diabetes
In the study to investigate the ability of an extract of black, green, and mulberry tea leaves to induce malabsorption of carbohydrate and triacylglycerol in healthy volunteers, found that with the carbohydrate-containing meal, the tea extract resulted in a highly significant increase in breath-hydrogen concentrations, which indicated appreciable carbohydrate malabsorption. A comparison of hydrogen excretion after the carbohydrate-containing meal with that after the nonabsorbable disaccharide lactulose suggested that the tea extract induced malabsorption of 25% of the carbohydrate. The tea extract did not cause triacylglycerol malabsorption or any significant increase in symptoms and concluded that this study provides the basis for additional experiments to determine whether the tea extract has clinical utility for the treatment of obesity or diabetes(3).
4. Etc.

Side Effects
No side effects as known
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Herbal Therapy: Herbal Andrographis Anti-inflammatory effects

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                 
                                Andrographis

 Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.


                          Anti-inflammatory effects


Inflammation is a condition of Immune system self-protection to remove harmful stimuli, including damaged cells, irritants, pathogens... from our body.

The Ingredients
Beside the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as: neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

The Benefits
Xiang-Qi-Tang (XQT), a herbal formular containing Andrographis paniculata, it found to be effective in inhibition of the expression of inflammatory and coagulant mediators via mitogen-activated protein kinase (MAPKs) and NF-κB signaling pathways on lipopolysaccharide (LPS)-induced inflammatory model of rat cardiac microvascular endothelial cells (RCMECs). Andrographolide (andro), one of the major components, also exerted it anti microbial effects by upregulation of human β-defensin-2 induced through p38 MAPK and NF-κB pathway in human lung epithelial cells. In other study, Andrograpanin, another isolated from Andrographispaniculata showed inhibition of productions of NO and pro-inflammatory cytokines through down-regulating iNOS and pro-inflammatory cytokines gene expression levels.

The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.

References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed) (2) Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells BY He CL, Yi PF, Fan QJ, Shen HQ, Jiang XL, Qin QQ, Song Z, Zhang C, Wu SC, Wei XB, Li YL, Fu BD. (PubMed)
(3) Andrographolide exerted its antimicrobial effects by upregulation of human β-defensin-2 induced through p38 MAPK and NF-κB pathway in human lung epithelial cells by Shao ZJ, Zheng XW, Feng T, Huang J, Chen J, Wu YY, Zhou LM, Tu WW, Li H.(PubMed).
(4) Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory property in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways by Liu J, Wang ZT, Ge BX.(PubMed)

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Herbal Therapy: Herbal Andrographis effect on Gastric Ulcer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                 
                                Andrographis

 Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.


                                                      Gastric Ulcer

 Gastric ulcers is defined as a condition of a localized tissue erosion in the liningthe stomach. as a result of bacteria Helicobacter pylori (H pylori) in most cases.


The Ingredients
Beside the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as: neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

The benefits
Andrographolide, a chief component of the leaves of Andrographis paniculata has been found to be gastroprotective effects as its antioxidants and mucin levels were significantly maintained in the gastric tissue of drug-pretreated animals with toxic effects in normal rats. hydroalcoholic extract of Andrographis paniculata (HAEAP), another chemical compound of Andrographis, has also exerted its overprotective effect by regulating effect on H(+)K(+)ATPase activity and /or mucin preserving effects and flavonoids presence in maintaining the antioxidants and thiol status in the gastrointestinal tract.
In some other studies pretreatment with ethonolic extract of A. paniculata ethanolic provided significant protection against gastric ulcer by regulating of pH, mucous production and antioxidant property.


The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.


References
(1) A biochemical study on the gastroprotective effect of andrographolide in rats induced with gastric ulcer. by Saranya P, Geetha A, Selvamathy SM.(PubMed)
(2) A biochemical study on the gastroprotective effect of hydroalcoholic extract ofAndrographis paniculata in rats. by Panneerselvam S, Arumugam G.(PubMed)
(3) Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats. by Wasman SQ, Mahmood AA, Chua LS, Alshawsh MA, Hamdan S.(PubMed)
(4) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)


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Thursday, October 6, 2016

Herbal Therapy: Herbal Andrographis effect on Common cold

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                 
                                Andrographis

 Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.


                                                     Common cold

 Cold and flu are the most commonly occurring illnesses in the entire world, with more than 1 billion colds per year reported in the United States alone. The common cold is a self-limiting illness caused by any 1 of more than 200 viruses. Influenza is no minor illness. If you are senior or have a serious heart and lung disease, you are at the greatest risk for coming down with a dangerous case of flu because your immune system might not be strong enough to fend off the infection.

The Ingredients
Beside the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as: neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

The benefits
In United States, common old causes 189 million lost school days and Influenza infection leads of morbidity and mortality, accounting for 20-25 million doctor visits and 36,000 deaths per year, Andrographis paniculata and nutritional considerations (vitamins A and C, zinc, high lactoferrin whey protein, N-acetylcysteine, and DHEA) may help in the prevention and treatment of these conditions. In the study of Andrographis paniculata SHA-10 extract, had found to be very effective supplement in reducing the prevalence and intensity of the symptoms in uncomplicated common cold beginning at day two of treatment and its dried extract found in Kan Jang tablets, attributes a protective effect of 33%, againstcommon colds during the winter period.

The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.


References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2) Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations by Roxas M, Jurenka J.(PubMed)
(3) Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study by Cáceres DD, Hancke JL, Burgos RA, Sandberg F, Wikman GK.(PubMed)
(4) Prevention of common colds with Andrographis paniculata dried extract. A Pilot double blind trial by Cáceres DD, Hancke JL, Burgos RA, Wikman GK. (PubMed)


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Herbal Therapy: Herbal Andrographis effect on Heart diseases

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                 
                                Andrographis

 Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.


                                                     Heart diseases

Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease. There are many causes of heart diseases. Most of heart diseases are caused by high blood pressure contributes to hardening of the arteries. High levels of bad cholesterol (LDL) build up in the arteries as a result of uncontrolled diet with high levels of saturated fat and trans fat. All these add to the formation of atherosclerosis lesions and eventually arterial blockage or anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart.


The Ingredients
Beside the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as: neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

The benefits
Neutrophils and inflammatory cytokines have been implicated in ischemia/reperfusion injury. Herbal Andrographis showed the cardioprotective effects by the suppression of oxidative stress and preservation of histoarchitecture of myofibrils along with improvement of haemodynamic and ventricular functions.Thromboembolic disorder is the development of clots within a blood vessel,
Andrographolide, a novel nuclear factor-κB (NF-κB) inhibitor, with the various medicinal properties of andrographolide may have a potential value in treating patients with thromboembolic disorders as andrographolide may involve an increase in cyclic GMP/PKG, followed by inhibition of the p38 MAPK/(·)HO-NF-κB-ERK2 cascade in activated platelets. Other study also indicated that andrographispaniculata protective effects of on post-infarction myocardium in experimental dogs, due to its acts on reversibly ischemic myocardium.

The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.


References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2) Protective effect of hydroalcoholic extract of Andrographis paniculata on ischaemia-reperfusion induced myocardial injury in rats by Ojha SK, Bharti S, Joshi S, Kumari S, Arya DS.(PubMed)
(3) Mechanisms of andrographolide-induced platelet apoptosis in human platelets: regulatory roles of the extrinsic apoptotic pathway by Lien LM, Su CC, Hsu WH, Lu WJ, Chung CL, Yen TL, Chiu HC, Sheu JR, Lin KH. (PubMed)
(4) Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade by Lu WJ, Lin KH, Hsu MJ, Chou DS, Hsiao G, Sheu JR.(PubMed)
(5) Protective effects of andrographis paniculata nees on post-infarction myocardium in experimental dogs by Zhao HY, Fang WY.(PubMed)


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Herbal Therapy: Herbal Andrographis effect on Immunity

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                 
                                Andrographis

 Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.


                                                     Immunity

 The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.

The Ingredients
Beside the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as: neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

The Benefits
HN-02, an extract containing a mixture of andrographolides, found in Andographis paniculata, not only significant increases in total WBC count in mice during 30 days of treatment with HN-02, but alsoenhances the immune function, possibly through modulation of immune responses altered during antigen interaction, and to reverse the immunosuppression induced by cyclophosphamide (CYP). Other in the study of modulation of immune responses in tumor cell destruction, treatment ofAndrographis paniculata extract (APE) and isolated compound andrographolide (ANDLE) significantly elevated the production of interleukin-2 and interferon-gamma and and IFN-gamma by T cells in normal and Ehrlich ascites carcinoma-bearing animals.

The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.

References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2|) Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata by Naik SR, Hule A.(PubMed)
(3) Modulation of natural killer cell activity, antibody-dependent cellular cytotoxicity, and antibody-dependent complement-mediated cytotoxicity by andrographolide in normal and Ehrlich ascites carcinoma-bearing mice by Sheeja K, Kuttan G.(PubMed)
(4) Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo by Andrographis paniculata extract and andrographolide by Sheeja K, Kuttan G.(PubMed)


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