All About Green Tea: Green tea, A Function Food In in Decreased Progression and Treatment of Her-2/ Positive Breast Cancer

Green tea may have a strong and positive impact in reduced breast cancer development in women with mutated gene HER2, some scientists suggested.

Breast cancers with HER2 gene amplification or HER2 protein overexpression are called HER2-positive HER2 is a protein that causes breast cancer cells to grow aggressively.


HER2-positive breast cancers tend to grow faster and are more likely to spread and come back in compared to HER2-negative breast cancers.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.


Breast cancer is a medical condition characterized by irregular cells growth in the breast tissues. At the late stage, cancerous cell may travel a distance away to infect other organs and tissues from original site.

The study of bioactive green tea polyphenol epigallocatechin-3-gallate (EGCG) was found to decrease progression of breast cancer cells with Her-2/neu over expression, through many mechanisms.

Application of green tea EGCG to Her-2/neu-driven mammary tumor cells showed a significant effect in blocking over expression of key regulators in the epithelial to mesenchymal transition (EMT) pathway in induced invasive cell proliferation in breast outer layer tissues.

Additionally, the bioactive compound also inhibited Her-2/neu-driven mammary tumor cells by enhanced genes expression in related to tumor suppressor(epithelial genes E-cadherin, gamma-catenin) and promoted tumor cell cycle arrest(MTA3) and involved in the regulation of cellular proliferation and differentiation in target tissues(estrogen receptor alpha (ERalpha)).

Further analysis the study also addressed the important role of green tea EGCG in inhibition of Her-2/neu-driven mammary tumor cells through decreased the function of snail gene in expression of tumor cells proliferative activity.

In cell migration and invasion assays, green tea EGCG also restrained branching colony growth and invasion of Her-2/neu-driven mammary tumor cells

Interestingly, invasive and metastatic I phenotypes in mouse mammary tumor cells driven by over expression of protein in transmuted transcription of DNA, involved cell survival and a messenger-independent in protect against apoptotic tumor cells also inhibited by administration of green tea EGCG.

Furthermore, green tea EGCG treatment activated FOXO3a in triggered apoptosis of tumor cells and reversed the invasive characteristic of in ERalpha-positive breast cancer cells by blocking expression of protein of transforming growth factor beta in induced tumor cell growth, cell proliferation, cell differentiation.


Further differentiation of over expression of the epidermal growth factor receptor family member Her-2/neu in breast cancer, application of EGCG not only inhibited mouse mammary tumor virus (MMTV)-Her-2/neu NF639 cell growth in culture and soft agar.but also ameliorated risk of basal Her-2/neu receptor tyrosine phosphorylation in contribution of exceptional oncogenic potency. via regulation of enzymes involved in cellular growth, proliferation, differentiation (phosphatidylinositol 3- kinase), and proteins in induced oncogenic transformation (Akt kinase to NF-kappaB pathway).


In SMF derived from mammary gland tumors and cultured and also epidermal growth factor receptor 4, green tea EGCG inhibited the expression of a significantly higher phosphorylation state of basal receptor which display high constitutive Her-2/neu tumor.

Interestingly in the study of epigallocatechin-3 gallate (EGCG) effects in inhibited growth of Trastuzumab-resistant HER2-driven breast cancer cells, researchers found that EGCG treatment in a dose-dependent inhibited trastuzumab-resistant BT474 human breast cancer cells, isolated by chronic trastuzumab exposure and JIMT-1 breast cancer cells, by decreasing tumor growth, tumor cellular ATP production in absorption of chemical energy obtained from the breakdown of food molecules and releases it to fuel other cellular processes, and by inducing tumor cells apoptosis at high concentrations.

Most importantly, EGCG also suppressed multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. of Akt activity, improved FOXO3a function in triggered apoptosis of tumor cells and elevated expression of anti tumor suppressor proteins. p27Kip1

Dr. Eddy SF , the lead author said, "EGCG in combination with trastuzumab may provide a novel strategy for treatment of HER2-over expressing breast cancers, given that EGCG can cross the blood-brain barrier".

Taking altogether, green tea with abundant bioactive polyphenol epigallocatechin-3-gallate (EGCG) may have therapeutic potential in reduced risk and progression of HER2 positive breast cancer, particularly when combined with other chemo-medicine.


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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate by Eddy SF1, Kane SE, Sonenshein GE.(PubMed)
(2) Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression reversing invasive phenotype of breast cancer cells by Belguise K1, Guo S, Sonenshein GE.(PubMed)
(3) Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells by Pianetti S1, Guo S, Kavanagh KT, Sonenshein GE.(CANCER RESEARCH 62, 652–655, February 1, 2002])

All About Green Tea: Green tea, A Function Food In Reduced Risk and Treatment of Ovarian Cancer

Green tea may have a potential effect in reduced risk and treatment of ovarian cancer, some institute studies suggested

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Ovarian cancer is a medical condition characterized by cell growth disorderly in the ovaries. At the late stage, cancerous cells may infect tissues and organs far away from the originated site.

In the analysis of the EGCG effects on 8 ovarian cancer cell lines (SKOV3, CAOV3, OVCAR3, OVCAR10, A2780, CP70, C30, and C200) and showed IC50s for EGCG at the micromolar range, researchers found that EGCG inhibited all ovarian cancer cell lines in dose depending manner.

Normal dose application of EGCG displayed a significant increase of antioxidant in reduced ROS over expression of oxidative stress in inhibited ovarian cancer through cell cycle arrest in G2/M phase.

Further differentiation also revealed that administration of EGCG at common dose not only demonstrated a 6 fold increase of cisplatin potency for treatment of SKOV3, CAOV3, and C200 cells, but also attenuated the chemodrug toxicity.

However, the effect of EGCG on the formation of reactive oxygen species (ROS) was biphasic.
The phytochemical was shown to induce and decrease ROS formation in different doses.

Therefore, higher dose of EGCG promoted over expression of antioxidants in reduced oxidative stress may amplify the toxicity in ameliorated human cancer cells proliferation and induced apoptosis.

Dr., the lead author said, "EGCG may accentuate oxidative stress to inhibit growth of ovarian cancer cells and sensitize them to cisplatin".

Other researchers in the study of toxicity of EGCG suggested that green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG) as a potent adjuvant to enhance the anti tumor efficacy of cisplatin while mitigating its harmful side effects through various mechanisms.

Application of EGCG showed to promote hyaluronic acid function in regulation of normal cell division and prevention of the acid in initiation of cancerous cell proliferation.

Hyaluronic acid, a polysaccharide molecule, plays an important role in cell proliferation and migration, and may involve in the progression of some malignant tumors.

Additionally, EGCG also expressed anti cancer effect by promoting the injection of chemo medicine cisplatin into the CD44-over expressing cancer cells to prevent over growth of tumor cells.

In regard to toxicity, EGCG on one hand, reduced over expression of oxidative stress in initiated toxicity against off-target organs and tissues through induction of a significant antioxidant activity on the hand, and stimulated function of toxicity originating from cisplatin into the target tumors on the other..

Further analysis, green tea catechin-based micellar nanocomplexes also inhibited superiorly against tumor growth with no injection of cisplatin and expressed a significant inhibition without induced toxicity in both cancer cells suspended in culture medium and injected into the animal models and peritoneal metastatic model of human ovarian cancer.

In other words, green tea catechin-based micellar nanocomplexes may be considered as a safe and effective cisplatin nanomedicine for ovarian cancer treatment..

More interestingly, in the additionally examined the effect of EGCG in suppressing ovarian cancer cell growth in 3 human ovarian cancer cell lines (p53 negative, SKOV-3 cells; mutant type p53, OVCAR-3 cells; and wild type p53, PA-1 cells),

EGCG decreased tumor growth in each cell line in a dose-dependent fashion and induced apoptosis and cell cycle arrest, particular to the G(1) phase in SKOV-3 and OVCAR-3 cells in compared to G(1)/S transition phase arrest in PA-1 cells.

The chemical also differentiately upregulated the expression of genes and proteins in promoted cancer cell arrest, suppressed tumor growth and induced cell death (Bax, p21, Retinoblastoma, cyclin D1, CDK4, Bcl-X(L)) by more than 2-fold

Taking altogether, green tea may have a profound effect in reduced risk and treatment of ovarian cancer through expression of phytochemical EGCG. However, intake of green tea extract must be taken with care, as overdoses were found to induce liver toxicity.

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Arthritis Is Curable
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Ovarian Cysts And PCOS Elimination
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FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Hyaluronic acid-green tea catechin micellar nanocomplexes: Fail-safe cisplatin nanomedicine for the treatment of ovarian cancer without off-target toxicity by Bae KH1, Tan S1, Yamashita A1, Ang WX1, Gao SJ1, Wang S1, Chung JE1, Kurisawa M2.(PubMed)
(2) Epigallocatechin-3-gallate delivers hydrogen peroxide to induce death of ovarian cancer cells and enhances their cisplatin susceptibility by Chan MM1, Soprano KJ, Weinstein K, Fong D.(PubMed)
(3) Anticancer effects of (-)-epigallocatechin-3-gallate on ovarian carcinoma cell lines by Huh SW1, Bae SM, Kim YW, Lee JM, Namkoong SE, Lee IP, Kim SH, Kim CK, Ahn WS.(PubMed)

All About Green Tea: Green tea, A Function Food In Reduced Risk and Treatment of Lung Cancer

Green tea may have a profound and extrinsic effect in reduced risk and treatment of lung cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will neurtalize the yin over expression.

Ginger, is a warm herb used in TCM to warm the Middle Burnner and the Lungs, rescues Yang, transforms Phlegm by enhancing the functions of lung, spleen and stomach channels.

Lung cancer is a medical condition characterized by cells growth disorderly and uncontrollably of lung tissues. At the late stage, the cancerous cells may travel a distance from the original site to infect other organs and tissues.

In the study to investigate the anti lung cancer effect of Epigallocatechin-3-gallate (EGCg), the major polyphenolic compound present in green tea, after taking inot account of other con founders, researchers at the joint study lead by the Kyushu University of Health & Welfare, suggested that
1. The phychemical induced apoptosis of lung cancer through suppression of cell division, in cell culture
2. In human A549 human non-small-cell lung cancer cell line, EGCg inhibited cancerous cell proliferation by interfering mRNA expression in modulation of apoptotic cell death
3. Additionally, application of 100 μM EGCg for 24 h. exhibited cancerous morphological changes, thus reducing cell proliferation

The study also revealed that the efficacy of EGCg inhibited B-cell lymphoma-extra large (Bcl-xL) through expression of mRNA and suppression of gene in related to cell death.


Further analysis of Epigallocatechin-3-gallate (EGCg) in inhibited gene expression in risk of lung cancer by binding HIF-1α, in promoted cell proliferation and anchorage-independent growth, researchers launched a study to elucidate the role of microRNA in the EGCG inhibition of tobacco carcinogen-induced lung tumors in A/J mice found that 26 potential targeted genes of the 21 microRNAs. with the mRNA expression profiles may have some implications in increased lung cancer risk.

Interestingly, application of EGCg, indeed, demonstrated a significant effect in improved cell regulation and reduced cell proliferation through many mechanisms, including regulation of

1. AKT pathway in promoted survival and growth in response to extracellular signals.
2. NF-κB expression in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation and
3. MAP kinases, involved variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival.

In other words, Epigallocatechin-3-gallate (EGCg) effect reduced risk and treatment of lung cancer is attributed to the inhibition of expression of RNA in transmitting information to proteins with function to initiated cancer cell change, including cell proliferation and apoptosis.


The findings also suggested that green tea Epigallocatechin-3-gallate (EGCg) has a strong effect in reduced risk lung cancer through both expression of mutate and cancer-related genes.

More importantly, mutated genes expression has been identified in contribution to cancer development and progression, therefore by target the expression of such genes may help scientists in explore the origins of abnormal gene expression in compared to normal cells.

Other researchers suggested that by targeting both DNA and RNA data to identify alternative expression of mutated gene in patients of lung cancer may open the door by offering specific treatment only for such patients

More precisely, by identified such gene in cancer cell patients, scientist may prescribe gene targeting technology, specific medication and treatment to stop cancer from growing and spreading.


Further differentiation of the effect of green tea extract in lung cancer risk, researchers at the University in Toruń filed the following report
1. Green tea extract catechins demonstrated a significant effect in inhibition of lung cancer line A549 independent to doses applied and
2. Increased cell and marker of cell degradation
3. Green tea extract catechins also expressed a strong protective effect in reduced self cause of toxicity

Collectively, this illustration indicated that green tea extract catechins exerted anti lung cancer progression through protection against destruction and damage of redundant cellular components occurring in vacuoles within the cell without induced side effects


The evidences indicated that certain phytochemicals found in green tea may have a potential in attenuated risk and treatment of lung cancer. But intake of green tea extract supplements have been found to induce liver toxicity, particularly if overdosed.
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea catechin, epigallocatechin-3-gallate, attenuates the cell viability of human non-small-cell lung cancer A549 cells via reducing Bcl-xL expression by Sonoda JI1, Ikeda R2, Baba Y3, Narumi K1, Kawachi A1, Tomishige E1, Nishihara K1, Takeda Y2, Yamada K4, Sato K5, Motoya T1.(PubMed)
(2) Gene regulation mediated by microRNAs in response to green tea polyphenol EGCG in mouse lung cancer by Zhou H, Chen JX, Yang CS, Yang MQ, Deng Y, Wang H.(PubMed)
(3) Green tea extract induces protective autophagy in A549 non-small lung cancer cell line by Izdebska M1, Klimaszewska-Wiśniewska A1, Hałas M1, Gagat M1, Grzanka A1.(PubMed)

All About Green Tea: Green tea, A Function Food for treatment of Osteosarcoma

Green tea may have a strong implication in reduced risk and treatment of osteosarcoma, some researchers suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Osteosarcoma is a medical condition of bone cancer characterized by producing immature bone and occurred mostly in children and young adults between the ages of 10 and 30.

According to the study in investigation of the effects of Epigallocatechin-3-gallate (EGCG), in reduced risk of osteosarcoma expression in compared to miR-126 in the proliferation, invasion, migration, and chemotherapeutics resistance in cancer, application of Epigallocatechin-3-gallate (EGCG)
1. Exerted a significant effect in suppresses proliferation of human cell line osteosarcoma MG63 and U2OS cells in a concentration-dependent and time-dependent manner
2. Inhibited cancer cell line at the concentration of 0.05 g/L on U2OS cells were equivalent to 20 μM cisplatin (DDP)

In compared to green tea extract induced cell death by interfering in cell cycle arrest, miR-126, the chemo suppressor drug induced apoptosis and inhibited proliferation in U2OS cell line but without significant effects on phase 1 of cancerous cell cycle division.


Further analysis, researchers suggested application of Epigallocatechin-3-gallate (EGCG) may increase the effect of tumor suppressing drug miR-126 and for treatment of osteosarcoma.

In fact, the inhibition of miR-126 osteosarcoma cells without inducing apoptosis and cells proliferation in cell cycle division is attributed to the medicine in target of sequences in reducing the expression of the targeted genes.


In other words, the medicine can bind directly to inhibit DNA transcription and prevented mRNA in transmitting such transcription in initiated cancer development.


Other researchers suggested that the inhibition of Epigallocatechin-3-gallate (EGCG) in reduced cancerous cell death does not limit to the function of cell cycle arrest, the phytochemical compoud also expressed the apoptotic effect through modulating gene expression of cancer cell line and induced degradation of cancerous cellular structure.


Additional evaluation of the phytochemical Epigallocatechin-3-gallate (EGCG) and the tumor suppressed drug miR-1 effect in osteosarcoma, researchers also found that Epigallocatechin-3-gallate has a profound and positive effect in improved the efficacy of miR-1 in induced cell apoptosis and proliferation observed in cancer cell lines MG-63 and U-2OS.

More importantly, MG-63 and U-2OS treated by miR-1 and Epigallocatechin-3-gallate (EGCG) decreased c-MET expression, which is an indication of cancers development.

Further more, combined application of Epigallocatechin-3-gallate (EGCG) and c-MET inhibitor (crizotinib) also displayed a significant inhibition of MG-63 and U-2OS cancer cell proliferation.

More interestingly, in the study of the effects of Se-enriched Ziyang green tea, containing chemical compound mannose, rhamnose and fucose in anti tumor activity on human osteosarcoma U-2 OS cells in vitro and in vivo, researchers found that Se-ZYTP at concentration of 25, 50, 100 and 200 μg/ml exetred a significantly inhibition of proliferation of human osteosarcoma U-2 OS cells in a concentration-dependent fashion.

In cancer cell line In U-2 OS cancer induced in BALB/c athymic mice model, Se-ZYTP oral administration at three doses of 100, 200 and 400mg/kg body weight (B.W.) daily for 28 days resulted in tumor regression as compared to model control without causing any serious side effects.


Once again, we illustrated that other chemical compounds found in green tea may also have the potential in suppression of proliferation and induced apoptosis of osteosarcoma.
In deed, the anti osteosarcoma activities of Se-enriched Ziyang green tea may be attributed to the stimulation in increased pro-apoptotic protein Bax expression(upregulated by the tumor suppressor protein p53 in induced apoptosis) and decreased expression levels of anti-apoptotic protein Bcl-2(regulator proteins that regulate cell death) and NG2(involved cell survival, migration and angiogenesis), some researchers suggested.



Taking altogether, green tea with plenty of phytochemicals in suppression of the development and progression of cancer may be considered as an adjunct therapy in reduced risk and combination with chemo drugs for treatment of osteosarcoma.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources

(1) Overexpression of miR-126 sensitizes osteosarcoma cells to apoptosis induced by epigallocatechin-3-gallate by Jiang L, Tao C, He A, He X1.(PubMed)
92) Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1 by Zhu K1, Wang W2.(PubMed)
(3) Tumoricidal effects of a selenium (Se)-polysaccharide from Ziyang green tea on human osteosarcoma U-2 OS cells by Wang Y1, Chen J, Zhang D, Zhang Y, Wen Y, Li L, Zheng L.(PubMed)

All About Green Tea: Green tea, in Prevention and Treatment of Alzheimer's disease

Green tea may an integrated form of treatment for patient with Alzheimer's disease through many mechanisms, a recent study proposed.

Green tea, considered as a functional food, linking numbers of health benefit has been reported by several renowned research and studies. However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. But a slice of ginger in the drink will neutralize the yin over expression in green tea.


Alzheimer's disease is a neuro-degenerative condition of loss or decrease of cognitive and memory functions due to aging.
According to the Maternal and Infant Health, ASL NA 3 SUD, epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG), found in green tea exerted a strong anti-inflammatory and anti oxidative properties in protection against neuronal damage and brain edema.

The study also stated that green tea may also contribute to reduced risk and treatment of AD by ameliorated chronic viral infection, one of the cause in responsible for AD's neuropathology.


Dr. Mandel SA. the lead author and expert in green tea study said, "tea drinking may decrease the incidence of dementia, AD, and PD. In particular, its main catechin polyphenol constituent (-)-epigallocatechin-3-gallate (EGCG) has been shown to exert neuroprotective/neurorescue activities in a wide array of cellular and animal models of neurological disorders".

Other researchers suggested that the efficacy of epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG) in reduced risk of AD may be attributed to
1. The antioxidant activity in ameliorate production of ROS in induced risk of oxidative stress which has been found to associate to production of lipid peroxidation, leading to abnormal deposition of amyloid β (Aβ) peptide

2. Free radical over expression in aging people also vulnerable to imbalance of antioxidant and ROS
may have a negatively direct interaction with proteins, nucleic acids, and other molecules and may also alter their structures and functions in inducing risk AD.


Indeed, as a single ingredient isolated from green tea, epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG) have been found to cause toxicity in some cases in medical literature. Therefore taking the ingredient in long term and overdoses may have a implication of liver damage.


In a animal study to evaluate the efficacy of Caffeic acid in AD, mice rats randomly divided into three groups: i) control group, ii) AD model group and iii) caffeic acid group, mice fed with the phytochemical expressed a significant in increased learning deficit and cognitive function demonstrated by the Morris water maze task in compared control.

Additionally, fed mice also displayed of attenuated oxidative stress, inflammation, nuclear factor‑κB‑p65 protein expression involved inflammatory cytokins production and suppressed caspase‑3 activity induced cell death and other mechanisms in the rats with AD.

Interestingly, inflammatory process has shown to have an negative role in increased risk of AD, by causing neuroinflammation, including brain cells such as microglia and astrocytes and subsequently in promoted dysfunction and neuronal death. Therefore by suppressing production of inflammatory cytokins, caffeic acid expressed a significant reduction of AD risk.


The efficacy in contribution of cognitive improvement following caffeic acid application may be due to its antioxidant activity and restoration of cholinergic functions, as deficiency of cholinergic function has shown to effect cognition, behavior and activities of daily living

Taking altogether, there is no doubt that green process a neuro protective against the risk and progression of patients with Alzheimer's disease (AD) attributed to some of the major chemical constituents. But intake of single ingredient isolated from green tea should be taken with care.
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources(1) The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer's disease: an overview of pre-clinical studies and translational perspectives in clinical practice by Cascella M#1, Bimonte S#1, Muzio MR2, Schiavone V3, Cuomo A1.(PubMed)
(2) Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases by Mandel SA1, Amit T, Weinreb O, Reznichenko L, Youdim MB.(PubMed)
(3) Effects of caffeic acid on learning deficits in a model of Alzheimer's disease by Wang Y1, Wang Y2, Li J1, Hua L3, Han B1, Zhang Y1, Yang X3, Zeng Z3, Bai H3, Yin H1, Lou J3.(PubMed)
(4) Caffeic acid attenuates oxidative stress, learning and memory deficit in intra-cerebroventricular streptozotocin induced experimental dementia in rats by Deshmukh R1, Kaundal M2, Bansal V2, Samardeep2(PubMed).

All About Green Tea: Green Tea Hepatoptotective Activity

Please note that this article does not embrace the use of single and multi ingredients extracted from green tea, particularly in the overdose state.


Green tea may have a potentially hepoprotective effect in prevention and treatment of liver disease, renowned institutes postulated.

Liver disease is a reduced function in toxin elimination of liver as a result of damage or injure, causing by medication, viral infection,....

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

According to the joint study lead by theZhujiang Hospital of Southern Medical University Guangzhou, in the review of the data base of PubMed, CNKI, Wanfang and Weipu databases, regular green tea drinking is associated to a significant reduction in the risk of liver disease, including hepatocellular carcinoma, liver steatosis, hepatitis, liver cirrhosis and chronic liver disease.

Also, Green tea demonstrated a reduced risk of liver disease regardless of the race and geography of the patients resided such as Asian, American and European subgroups.
Unfortunately, in a mouse model, different doses of GT fractions and EGCG and a single dose of lipopolysaccharide (LPS) combined with EGCG, administered for 5 days to mice suggested that mice fed with combining a single high dose of EGCG with a single dose of LPS showed to induce liver injury.

Repeat injection of EGCG in the group also found to associate to mild liver injure, probably was attributed to the adverse effect of lipopolysaccharide (LPS), the study insisted.

Epigallocatechin Gallate (EGCG) is one of the major and powerful antioxidant of green tea found to be most effective cancer chemopreventive polyphenol in many studies posted on medical literature. However, the single ingredients extract has also been found to induce hepotoxocity and acute liver dysfunction in many occasions due to overdoses and long term usages.

Additionally, according to the Baylor College of Medicine and Dalhousie University, Halifax reported, "(There is) a case of acute impending liver failure in an adolescent male using a weight-loss product containing green tea extract" and "acute liver toxicity observed in individuals consuming supplements containing green tea extract".

Taking altogether, the conflict result of green tea in liver disease may be result of study design, group selection, sample size, doses intake,........People with liver disease should talk to a specialist of herbal products before consuming.


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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A Simple Cooking Technique That Cuts The Calories & Glycemic
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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources

(1) The effect of green tea intake on risk of liver disease: a meta analysis by Yin X1, Yang J2, Li T3, Song L4, Han T5, Yang M1, Liao H1, He J1, Zhong X1.(PubMed)
(2) Effect of green tea and its polyphenols on mouse liver by Saleh IG1, Ali Z, Abe N, Wilson FD, Hamada FM, Abd-Ellah MF, Walker LA, Khan IA, Ashfaq MK.(PubMed)
(3) Green tea extract: a potential cause of acute liver failure by Patel SS1, Beer S, Kearney DL, Phillips G, Carter BA.(PubMed)
(4) Acute liver failure induced by green tea extracts: case report and review of the literature by Molinari M1, Watt KD, Kruszyna T, Nelson R, Walsh M, Huang WY, Nashan B, Peltekian K.(PubMed)
(5) Effect of epigallocatechin gallate on uncoupling protein 2 in acute liver injury by Mohammad H Jamal,1,* Hamad Ali,2 Ali Dashti,2 Jasim Al-Abbad,1 Husain Dashti,1 Chako Mathew,2 Waleed Al-Ali,3 Sami Asfar1(PubMed)

All About Green Tea: Green Tea and the Risk of Renal Disease

Green tea showed to inhibited or exhibited kidney function in toxin elimination in deteriorated renal function in patient with chronic renal disease, studies proposed.

Renal Disease is an impaired function in toxin elimination for more than a specific time as a result of kidney damage or injure.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will be helpful to solve the problem.


In mice fed with a powdered diet containing green tea polyphenolic extract (0.1%) starting 3 days prior to CsA treatment (25 mg/kg, i.g. daily for 3 weeks).showed a decreased renal nuclear DNA-encoded oxidative phosphorylation (OXPHOS) protein ATP synthase-β (AS-β)by 42%, mitochondrial DNA (mtDNA)-encoded OXPHOS protein NADH dehydrogenase-3 (ND3) involved oxidize nutrients for energy conversion by 87%.

Flavanols (polyphenols) are rich phytochemicals isolated from green tea, particularly in the expression in form of most bioactive flavanol EGCG.

Oxidative phosphorylation (OXPHOS) protein ATP synthase-β (AS-β) plays a key role in energy production and regulated the generation of free radicals, and apoptosis through respiratory chain.

Mitochondrial DNA (mtDNA)-encoded OXPHOS protein NADH dehydrogenase-3 (ND3) in reduced risk of gene mutation through oxidative phosphorylation (OXPHOS).

Dr. Rehman H, the lead author said," Green tea polyphenols markedly attenuated CsA-induced renal injury and improved renal function. Together, these results demonstrate that green tea polyphenols attenuate CsA-induced kidney injury, at least in part, through the stimulation of MB".
In support of the efficacy of green tea for treatment of renal disease, the study of F40 rats randomly divided into 4 groups. Group 1 acted as control; group 2 received contrast medium (intravenous iodixanol, 10 mL/kg, as a single dose); group 3 received contrast medium and then green tea extract for 3 days (10 mg/kg/d, intraperitoneal); and group 4 first received green tea and then contrast medium, researchers showed that group treated with green tea had significantly higher overall scores than the control group.

Treatment group also expressed a significant improvement in progression of renal degeneration caused by nephrotoxicity of contrast media.

Unfortunately, according to the joint study lead by the China Medical University, inhibited the elimination of indoxyl sulfate (IS) and p-cresyl sulfate (PCS), a highly protein-bound nephro-cardiovascular toxins in CRF rats.

Catechin, is another major chemical constituent isolated from Green tea (GT) and a popular beverage in China.

Indoxyl sulfate(IS), a circulating uremic toxin has found to associate to the development of glomerular sclerosis and interstitial fibrosis.

P-Cresyl sulfate (pCS) is also an uremic toxin generated by intestinal bacteria
which has an implication to worsen outcome of patients with chronic kidney disease and increased cardiovascular burden.


Furthermore, green tea injection of catechin.in experiment mice also showed a significantly increased the levels of serum creatinine (Cr) and blood urea nitrogen (BUN), an indication of further kidney damage after ingestion of green tea catechin.

Dr. Peng YH, the lead author said, "GT inhibited the elimination of nephro-cardiovascular toxins such as IS and PCS, and deteriorated the renal function in CRF rats".


Taking together, the conflict results of green tea in expression of chronic renal disease may be due to study design, the group sample, the subject selection doses administration,........., therefore patients with renal disease should be consult with specialists before taking.

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources

(1) Green tea inhibited the elimination of nephro-cardiovascular toxins and deteriorated the renal function in rats with renal failure by Peng YH1, Sweet DH2, Lin SP1, Yu CP1, Lee Chao PD1, Hou YC1,3,4.(PubMed)
(2) Green tea polyphenols stimulate mitochondrial biogenesis and improve renalfunction after chronic cyclosporin a treatment in rats by Rehman H1, Krishnasamy Y, Haque K, Thurman RG, Lemasters JJ, Schnellmann RG, Zhong Z.(PubMed)
(3) Ameliorative effect of green tea against contrast-induced renal tubular cell injury by Nasri H, Hajian S, Ahmadi A, Baradaran A, Kohi G, Nasri P, Rafieian-Kopaei M1.(PubMed)