Eggplant, The Veggie Which Normalizes the Blood Cholesterol with No Side Effects

Eggplant may process a significant effect in decreasing the risk and onset of abnormally high blood cholesterol, some scientists suggested
Cholesterol, the waxy substance produced by the liver or intake from the dietary sources plays an important role in the building of the cell walls, producing steroid hormones and promoting the digestive function in food digestion.
However, high levels of blood cholesterol can weaken the arterial wall and block the blood flow in the arteries, leading to the substantially increased the risk of heart diseases and stroke.
The ratio of total cholesterol is 4/1, any numbers that are less than is considered within the healthy range. The lower of the ratio is an indication that you have a higher than normal amount of high-density lipoprotein (HDL), which is essential to remove blood cholesterol from the blood back to the liver, leading to less low-density lipoprotein (LDL) in the initiation of cardiovascular diseases.
.
The below table Classification of cholesterol levels, provided by Dr.Michael Tanner and Dr. Nate Link the lead author at the New York University School of Medicine and Bellevue Hospital Center New York,

Cholesterol, mmol/L (mg/dL)ClassificationTotal
<5.17 (<200) Desirable
5.17-6.19 (200-239) Borderline
≥6.20 (≥240) High
HDL-C Classification
<1.00 (<40) Low
≥1.43 (≥60) High

US prevalence (%) of high total cholesterol levels (≥6.21 mmol/L [≥240 mg/dL]) and coronary artery disease (NHANES III: 1988-1991)1

Age, yrHigh cholesterol levelCoronary artery disease
MenWomenMenWomen20-34 9 8 2 3
35-44 18 11 3 4
45-54 25 23 9 6
55-64 25 37 17 12
65-74 22 39 17 11
≥75 14 32 23 16


Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India.
The plant has been cultivated in southern and eastern Asia since prehistory. It is famous with its deeply purple and the best eggplant can be found from August through October when it is in season.
Chemical constituents of eggplant include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin and other Polyphenolic compounds.


In the study to reaffirm the Eggplant (Solanum melongena) consumed extensively in Brazil may have a strong effect in reducing the serum cholesterol researchers at the Instituto de Ciências Biológicas conducted an evaluation to test the plant cholesterol metabolism and hypocholesterolemic effect
In the total of 38 hypercholesterolemic human volunteers ingesting S. melongena infusion for five weeks, 38 hypercholesterolemic subjects were given either S. melongena infusion (N = 19) or placebo (N = 19) participated in two clinical experiments in which the effect of S. melongena infusion was studied with (N = 16) or without (N = 38) dietary orientation.
S. melongena infusion significantly reduced the blood levels of total and LDL cholesterol and of apolipoprotein B.
After dietary orientation, no intra- or intergroup differences were seen for any of the parameters analyzed.
The results suggest that S. melongena infusion had a modest and transitory effect, which was not different from that obtained with standard orientation for dyslipidemia patients (diet and physical activities).

Dried powdered fruits of eggplant (Solanum melongena) was tested in a double-blind placebo-controlled study of the effectiveness of oral Solanum melongena (SM) consisted of 41 hyperlipidemic volunteers allocated to active treatment (n= 21) or placebo (n= 20).
Each volunteer received two capsules containing SM (450 mg) or placebo (450 mg) twice daily and was followed monthly. The dose of SM used corresponds to that given to treat hyperlipidemia in Brazil.
After 3 months, serum total cholesterol, LDL-c, and LDL-c/HDL-c decreased (p<0.05) in the group treated with SM.
Dr. Silva GE, the lead author wrote at the final report of the study, " SM, at least in the form commercialized in Brazil (dried powdered fruits), require further clinical trials before being recommended to treat hyperlipidemia".

Taken altogether, eggplant may be considered a functional food for the prevention and an adjunct therapy for the treatment of high blood cholesterol with no side effects.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) Eggplant (Solanum melongena) infusion has a modest and transitory effect on hypercholesterolemic subjects by Guimarães PR1, Galvão AM, Batista CM, Azevedo GS, Oliveira RD, Lamounier RP, Freire N, Barros AM, Sakurai E, Oliveira JP, Vieira EC, Alvarez-Leite JI.(PubMed)

(3) [Absence of hypolipidemic effect of Solanum melongena L. (eggplant) on hyperlipidemic patients].[Article in Portuguese] by Silva GE1, Takahashi MH, Eik Filho W, Albino CC, Tasim GE, Serri Lde A, Assef AH, Cortez DA, Bazotte RB.(PubMed)
(4) Hyperlipidemia: Part 1. Evaluation and dietary management by Michael Tanner1 and Nate Link.(PMC)

Black beans, The Legume in the Prevention and Treatment of Benign Prostatic Hyperplasia (Enlarged Prostate)

Black bean, a glossy black shell legume may have a potential effect in protecting the prostate gland against the onset of prostatic hyperplasia, scientists found.

Prostatic hyperplasia is a medical condition associated with the enlarged prostate that impedes the urinary flow.

The prostate is a gland that surrounds part of your urethra, the tube with a function to carry urine and semen out of men penis.

The condition is found mostly in aging men, as a result of free testosterone converting to hormone dihydrotestosterone (DHT). Overabundant DHT in the men body is a major cause of an enlarged prostate.

Truly, DHT has been found to plays a beneficial role in the developing prostate but it can be detrimental in the adult prostate in facilitating pathologic prostate growth, including the enlarged prostate.

The role of DHT in other adult tissues is uncertain. DHT has not been shown to perform beneficial functions unique from testosterone in the adult male, and it is believed that its fundamental effect may amplify testosterone's weaker hormonal signal.

The 5alpha-reductase inhibitors play an important role in the protection of the prostate gland by blocking the process of prostate diseases, by reducing the prostate volume, and reduce the risk of acute urinary retention and enlarged prostate.

5alpha-reductase inhibitors have been found in the low levels in an aging male with prostate diseases.


Some researchers suggested that by targeting the conversion of testosterone to DHT, the enlarged prostate can be preventable.

Men who follow an unhealthy diet and lifestyle of the Western diet with a lot of saturated and trans fat, red meat, process and less in fruits and vegetable and whole grain are associated with a substantial risk of the early onset of LUTS (lower urinary tract symptoms) in describing the symptoms related to problems of the lower urinary tract (bladder, prostate, and urethra), including enlarged prostate.

Dr. Pao-Hwa Lin, the lead author in the study "Lifestyle and LUTS: what is the correlation in men?" reconfirm these statements said, "1) Epidemiological data repeatedly show a favorable relationship between healthy eating habits and regular physical activity level and a lower risk for LUTS or progression of LUTS, 2) certain specific nutrients or dietary factors may contribute to the link between diet and LUTS due to their anti-inflammatory potential, and 3) very little research has been conducted to test the epidemiological findings in randomized controlled trials".

"A healthy lifestyle with good quality diet and regular physical activity is beneficial not only for potentially improving or reducing LUTS but also for cardiovascular and overall health".


In other words, an enlarged prostate can be preventable in aging male, if they follow a healthy diet and lifestyle with moderate exercise.

Black bean is a small roughly ovoid legume with glossy black shells, genus Phaseolus, belonging to the family Fabaceae.

The legume can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

Chemical constituents of black bean include
The major chemical compounds of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.

In the examination to reconfirm the effect of black soybeans on benign prostatic hyperplasia (BPH), researchers launched an investigation to evaluate the anti benign prostatic hyperplasia (BPH) anthocyanin extracted from the legume on rat induced enlarged prostate.

The study included a total of male rats whose were divided into five experimental groups: a control group, a BPH-induced group, and three BPH-induced groups that received oral doses of anthocyanin (40, 80, and 160 mg/kg).


Prostate hyperplasia was induced by the administration of testosterone propionate for 4 weeks.

Anthocyanin-treated groups received the compound for 4 weeks after the induction of enlarged prostate.

The mean prostate weights for the rats receiving 40, 80, and 160 mg/kg anthocyanin were 323.00, 324.00, and 617.50 mg, respectively.

This assessment indicated the preferred dose of anthocyanin in the prevention of enlarged prostate is 40 mg.

In groups comparison, the average prostate weight in the BPH-induced group was significantly higher than in the control group (p < 0.05), whereas the prostate weights in the anthocyanin-administered groups were significantly lower than in the BPH-induced group (p < 0.05).

Furthermore, anthocyanin administration helped to prevent the change of prostate weight caused by injecting testosterone to induce prostatic hyperplasia.

Moreover, apoptotic body counts were significantly higher in groups receiving anthocyanin than in the BPH-induced group.

These results suggested that anthocyanin may be effective in decreasing the volume and suppressing the proliferation of the prostate, through inhibiting the conversion of testosterone to hormone dihydrotestosterone (DHT).

Additionally, in the testing to examine whether Seoritae extract (SE) form the black soybeans have beneficial effects on the reduction of prostate weight in a rat model of benign prostatic hyperplasia (BPH), researchers at the joint study led by the The Catholic University of Korea College of Medicine conducted an experiment with BPH induced by intramuscular injections of testosterone enanthate once a week for 5 weeks in Sprague-Dawley rats, then rats were treated with or without daily oral doses of SE during BPH induction.

After 5 weeks, the SE treatment group showed a significant decrease in prostate weight, oxidative stress, apoptosis, and 5alpha-reductase activity compared to the nontreated BPH group.

These results coincidently showed that SE is effective in decreasing the weight and proliferation of the prostate similar to those of the above study

Dr. Hoon Jang, the lead scientists suggest that SE may be an effective treatment for BPH.

Taken all together, black beans containing the abundant major bioactive compound anthocyanin may
be considered a functional food for the prevention and treatment of the early phase of enlarged prostate with no side effects, depending on the further the human studies.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



References
(1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments.
Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Seoritae Extract Reduces Prostate Weight and Suppresses Prostate Cell Proliferation in a Rat Model of Benign Prostate Hyperplasia by Hoon Jang,1 Woong-Jin Bae,1 Seung-Mo Yuk,1 Dong-Seok Han,1 U-Syn Ha,1 Seong-Yeon Hwang,2 Shin-Hee Yoon,3 Sae-Woong Kim,1 and Chang-Hee Han. (Hinwadi)
(3) Anthocyanin extracted from black soybean reduces prostate weight and promotes apoptosis in the prostatic hyperplasia-induced rat model. by Jang H, Ha US, Kim SJ, Yoon BI, Han DS, Yuk SM, Kim SW. (PubMed)
(4) Lifestyle and LUTS: what is the correlation in men? by Pao-Hwa Lin, PhD1 and Stephen J. Freedland, MD. (PMC)

Banana Enhances the Immune Function Against Infectious Diseases

Scientists may have found a whole food which processes a potential effect to improve the function of the immune system against infectious micro-pathogens, some studies suggested.

The immune system is the body's defense against infectious organisms and other invaders, by activating the systematic immune response.

In the acute phase of infection, macrophages, the first line of immune defenses stimulate the production of proinflammatory cytokines to the site of infection with an aim to protect the injured or damaged tissue against foreign invasion.

However, overproduction of the proinflammatory cytokines can cause damage to the healthy cells and improper healing with the formation of scars.

Immune system disorders are a chronic condition caused by the abnormal under-activity or over-activity of the immune system.

In an overactive immune system or autoimmune disorders, the immune white blood cells mistakenly attack and damage the bodily tissue.

The underactive immune disorders are also known as the immune deficiency diseases, weakening the immune ability to fight invaders, and increasing the risk of infections.

Dr. Wypych TP, the lead author in the study "The Impact of Diet on Immunity and Respiratory Diseases" wrote, "the "diet hypotheses," pointing to the importance of changes in our dietary habits" and "the interplay between the Western diet, microbiota, and inflammatory conditions".

In other words, the Western diet high in saturated and trans fat, a lot of red meats, processed foods and less in fruits and vegetable may play an important role in either weakening the immune system or causing overactive immune system in the facilitation of the onset of autoimmune diseases.

Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belonging to the family of the lily and the orchid.

In the examining the effect of the hot-extracts isolated from fruit's peel of banana on human health researchers at the joint study led by the National Pingtung University of Science and Technology launched an evaluation to observe the antibacterial activity from aquatic animals, and immunostimulating potential, disease resistance and anti-hypothermal stress in giant freshwater prawn, Macrobrachium rosenbergii.

The injection od banana hot extracts demonstrated strong activity against 1 Gram-positive and 3 Gram-negative pathogens, including Lactococcus garvieae, Photobacteria damsella.

Prawn received BPE via injection at 1-6 μg (g prawn)(-1) significantly enhanced the immunity through the increased total hemocyte count (THC), hyaline cell (HC), granular cell (GC), phenoloxidase (PO) activity and phagocytic activity against L. garvieae from 3 to 6 days.

The extracts also significantly increased clearance efficiency against L. garvieae and a significantly decreased coagulation time of prawn from 1 to 6 days and levels of antioxidant enzymes in the body.

The survival rates of Macrobrachium rosenbergii injected with BPE at concentrations of 1, 3 and 6 μg (g prawn)(-1) were significantly higher than those injected with saline control after challenge with L. garvieae for 4-6 days, and the respective relative survival percentages of prawn were 28.6%, 38.1%, and 47.8%, respectively at 6 days, an indication of the improved immune system against the attack of pathogens.

These results suggested that BPE may be a pharmaceutical candidate to be used as the bacteriostat, and immunostimulant and physiological regulator through enhancing the immunity, physiological responses, and resistance against infectious stimuli.

Additionally, in the evaluate the antagonistic mechanisms of Lactobacillus plantarum CIF17AN2 (an infant isolate), saba starch (banana), and their synbiotic combination against Salmonella Typhimurium SA2093, researchers found that
* The L. plantarum CIF17AN2 exhibited anti-Salmonella mechanisms through secretion of antimicrobial compounds, adhesion ability and competitive adhesion to mucin on HT-29 cell line.

* The effects of Lactobacillus plantarum CIF17AN2 on the Salmonella inhibition was significantly reduced in the presence of human fecal microflora.

* The combination of saba starch with L. plantarum CIF17AN2 showed the greatest inhibition against Sal. Typhimurium SA2093 in the colon model.

* The enhancement of anti-Salmonella activity due to the addition of saba starch corresponded a significant decrease in pH and an increase of lactic acid and short chain fatty acids.


These results suggested that banana starch can be used alone or combined with other ingredients for the treatment of Salmonella T. infection.


Taken altogether, banana may be considered a function in enhancing the immune function against microorganisms, which cause infectious diseases, depending on the confirmation of further data collection from the large example size and multi-center studies in human.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effects of hot-water extract of banana (Musa acuminata) fruit's peel on the antibacterial activity, and anti-hypothermal stress, immune responses and disease resistance of the giant freshwater prawn, Macrobrachium rosenbegii by Rattanavichai W1, Cheng W. (PubMed)
(2) Antagonistic mechanisms of synbiosis between Lactobacillus plantarum CIF17AN2 and green banana starch in the proximal colon model challenged with Salmonella Typhimurium by Uraipan S1, Brigidi P2, Hongpattarakere T3. (PubMed)
(3) The Impact of Diet on Immunity and Respiratory Diseases by Wypych TP1, Marsland BJ1, Ubags NDJ.(PubMed)

Avocado, the Fruit Which Kills Breast Cancer Cells in Vivo and Vitro

Avocado may be considered a potentially functional fruit for the prevention and treatment of breast cancer, some scientists suggested.

Breast cancer is the medical condition that starts on the surface of the inner lining of breast tissue in the early stage. On this stage, a small lump may be found when touched.

The 5 years survival rate at this stage is 100%.

However, at the later stage, malignant cancers cell can travel a distance away from the original site to infect other healthy tissue and organs.

The lifetime risk for a woman to develop breast cancer is 1/8 in the US.

The epidemiological studies suggested that women who carry the mutated gene BRAC1 and 2 are associated with substantially increased risk of the disease onset.

Men who carry the mutated gene BRCA2 have a 7% lifetime risk of developing breast cancer.

Sadly, women who carry the abnormal BRCA1 orBRCA2 gene have about a 60% risk of being diagnosed with breast cancer during their lifetimes, compared to only 12.5% for other women.

In a comment of the study published on June 20 in the Journal of the American Medical Association Dr. García-Closas, M.D., Dr.P.H., deputy director of NCI's Division of Cancer Epidemiology and Genetics, who was not involved in the research. said, “This study has confirmed estimates of the risk of developing cancer for women who are mutation carriers—that confirmation is reassuring for both women and the healthcare team who make important care decisions.”

Therefore, suggestions to these women may include intensive early surveillance, use of chemoprevention, and prophylactic surgery may be necessary for the prevention and treatment of breast cancer.

Avocados are a commercially valuable fruit and are cultivated in tropical climates throughout the world, it is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

Chemical constituents of avocado include
The fruit contains campesterol, high amounts of β-sitosterol (average 76.4 mg/100 g); fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B.

Persin, the toxic chemical compound found in the fruits and leaves of avocado inhibited human breast cancer cell line, in the testing of synthetic analogs of the avocado-produced toxin persin by activated the program cells death pathway.

When using combined with tamoxifen, the small amounts of tamoxifen needed to perform similar chemo effects, thus reducing the toxicity to the healthy cells that normally killed by the presence of tamoxifen.

Futhermore, in the study to examine the anticancer properties of Persea declinata (Bl.) Kosterm bark methanolic crude extract (PDM), researchers at the University of Malaya launched an investigation to test the PDM in the exhibition of antiproliferative effect in MCF-7 human breast cancer cells.

Application of the PDM exhibited a potent antiproliferative effect in MCF-7 human breast cancer cells, with an IC50 value of 16.68 µg/mL after 48 h of treatment.

Injection of PDM caused cell cycle arrest and subsequent apoptosis in MCF-7 cells, as seen by increase population at the G0/G1 phase and, higher lactate dehydrogenase (LDH) release, and DNA fragmentation, the indications of cancer cells apoptosis.

Additional analysis suggested that PDM elevated the expression of ROS in the induction of cancer cell death through cytotoxicity observed by the perturbation of mitochondrial membrane potential, cell permeability, and activation of caspases-3/7, in the execution phase of apoptosis.

The results of cancer cells apoptosis can be observed through the increased the expression of the proapoptotic molecule, Bax, but decreased the expression of prosurvival proteins, Bcl-2 and Bcl-xL, in a dose-dependent manner after PDM administration.

The finding strongly suggested that PDM isolated from avocado could inhibit proliferation in MCF-7 cells via cell cycle arrest and apoptosis induction.

Taken altogether, avocado may be considered a functional fruit for the prevention and an adjunct therapy combined with conventional medicine for the treatment of breast cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of the avocado anti-breast cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) Leung's Encyclopedia of Natural Ingredients: Chemical Composition of Avocado
(1) Synthesis and in vitro evaluation of analogs of avocado-produced toxin (+)-(R)-persin in human breast cancer cells by Brooke DG1, Shelley EJ, Roberts CG, Denny WA, Sutherland RL, Butt AJ. (PubMed)
(2) Persin - the avocado toxin that kills breast cancer cells(Gavan Institution)
(3) Persea declinata (Bl.) Kosterm Bark Crude Extract Induces Apoptosis in MCF-7 Cells via G0/G1 Cell Cycle Arrest, Bcl-2/Bax/Bcl-xl Signaling Pathways, and ROS Generation by Narrima P1, Paydar M1, Looi CY1, Wong YL1, Taha H2, Wong WF3, Ali Mohd M1, Hadi AH(PubMed).

Dried Pea, The Legume Which May Process Anti Colon Cancer Potency

Dried peas with high of fiber may have a potential effect in the prevention and treatment of colon cancer.

Colon cancer is a chronic and medical condition characterized by cells growth uncontrollably and disorderly that start on the surface of the inner lining of colon tissue.

At the advanced stage, the cancerous cell can travel a distance away from the original site to affect other healthy tissue and organ through the circulation of blood and fluids.

The exact causes of colon cancer are unknown. However, researchers do know that unhealthy diet and lifestyle with physical inactivity are associated with a substantially increased risk of colon cancer.

Epidemiological studies agreed that the Western diet is associated with the increased risk and recurrent risk of colon cancer.

Ms. Marilisa Racco at the National Online Journalist, Smart Living Global News wrote "There’s more bad news for lovers of red meat and refined grains — also known as a Western diet — from cancer researchers. A new study has found that a pro-inflammatory diet that’s heavy in processed red and organ meat, refined grains, and sugary drinks, will significantly increase the risk of developing colorectal cancer in both men and women".

Furthermore, a higher intake of a Western dietary pattern after cancer diagnosis was also associated with recurrence and death in colon cancer patients.

Publish on the Public Medical Literature, the study includes a total of 1009 patients with stage III colon cancer.

Researchers said, "During a median follow-up of 5.3 years for the overall cohort, 324 patients had a cancer recurrence, 223 patients died with cancer recurrence, and 28 died without documented cancer recurrence".

These result suggested that genetic preposition and an unhealthy diet and lifestyle the major risk factors that associate to the onset of colon cancer and recurrent colon cancer.


Dried peas are the small but nutritionally mighty member of the legume family, the genus Pisum belonging to the family Fabaceae.

The bean has a healthy source of protein, fibers, vitamins, and minerals that are good for everyone diet.

Besides it main component of the polyphenolic compound, dried bean also contains saponin pisatin, L-pipecolic acid, glycoside-Pisatoside, tocopherols, cerebroside, etc.

In the study to reaffirm the polyphenolics and saponins effect in the stimulation of antioxidant enzymes in the host and anticarcinogenic activity, researchers launched an investigation to examine the naturally occurring plant protease inhibitors which have potential health-promoting properties within the mammalian gastrointestinal tract against the risk of colon cancer.
Bowman-Birk inhibitors (BBI) isolated from peas exerts anti-carcinogenic and anti-inflammatory properties in the large intestine by surviving from both acidic conditions and the action of proteolytic enzymes in the stomach and small intestine,

A recombinant form of TI1B (rTI1B), representing a major BBI isoinhibitor from pea also inhibited the growth of human colorectal HT29 cells in vitro.

The proliferation of HT29 colon cancer cells was significantly affected by the injection of rTI1B in a dose-dependent manner (IC50 = 31 (sd 7) μm), compared to the novel engineered mutant.

Interestingly, application of rTI1B induced HT29 colon cancer cells apoptosis without affecting the nearby healthy cells.

Furthermore, the rTI1B proved to be active against trypsin and chymotrypsin in facilitating the colorectal carcinogenesis and promotes proliferation, invasion, and metastasis.

Proteases inhibitor isolated from the peas may process a potential chemopreventive effect during the early stages of colorectal carcinogenesis.


Adding 1 or 2 portions of dried peas into a daily diet in high colon cancer risk patients may reduce the incidence of colon cancer.


Taken all together, dried peas may be considered a function legume in the prevention and adjunct therapy for the treatment of colon cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the dried peas or its bioactive compounds during the course of the disease will be necessary to complete the picture of its anti-colon cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Review of the health benefits of peas (Pisum sativum L. by Dahl WJ, Foster LM, Tyler RT. (PubMed)
(2) The anti-proliferative effect of TI1B, a major Bowman-Birk isoinhibitor from pea (Pisum sativum L.), on HT29 colon cancer cells is mediated through protease inhibition by Clemente A, Carmen Marín-Manzano M, Jiménez E, Carmen Arques M, Domoney C.(PubMed)
(3) Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer by Meyerhardt JA1, Niedzwiecki D, Hollis D, Saltz LB, Hu FB, Mayer RJ, Nelson H, Whittom R, Hantel A, Thomas J, Fuchs CS. (PubMed)

Strawberries, The Functional Food Which Inhibits the Risk Factors of the Onset of Atherosclerosis

Strawberries may be considered a functional food that blocks the plaque accumulated in the arteries, causing atherosclerosis, some scientists suggested.

Atherosclerosis is a medical condition of heart disease characterized by plaque building up in the inner wall of the arteries.

Where arteries are blood vessels that carry oxygen and nutrient-rich blood to the heart and other organs and tissue of the body and plaque is the substance made up mostly with fat, cholesterol, calcium.

According to the statistics, atherosclerosis causes 32% of deaths of heart disease. The prevalent rate of the disease onset among adults of 20 years and above is 13.8%.

Dr. Singh RB, the lead author in the assessment of diet and exercise and lifestyle on risk of atherosclerosis conducted a randomized, single-blind, controlled trial, 621 patients assigned either intervention diet A (group A, 310 patients) or control diet B (group B, 311 patients) for a period of 24 weeks.


Where participants of group A are received: (1) a diet with a higher percentage of calories from fruits and vegetables and complex carbohydrates; (2) a higher polyunsaturated/saturated fat ratio diet; and (3) a larger amount of soluble dietary fiber, antioxidant vitamins and minerals and low saturated fat and cholesterol than group fB. Group A patients also did more physical and yogic exercises than group B.

After 24 weeks of intervention, he wrote. " There was a significant decrease in serum total cholesterol (13.3%), low-density lipoprotein cholesterol (16.9%), triglycerides (19.2%), fasting blood glucose (19.5%) and blood pressures (11.5/6.2 mm Hg) in the intervention group compared with initial levels and changes in group B".

These result suggested that a healthy diet accompanied by moderate exercise are the major factors that can substantially reduce the risk of atherosclerosis. In other words, people who follow the Western diet with physical inactivity are at higher risk to the onset of the disease.

Strawberries are a genius of Fragaria × ananassa belonging to the family Roseaceae.

They have been grown all over the world in a suitable climate for commercial profits and health benefits.

The major chemical compounds of strawberry include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

Intake of strawberry daily to improve the potent antioxidants status in the body can reduce cardiovascular risk factors, such as elevated blood pressure, hyperglycemia, dyslipidemia, and inflammation in limited studies.

Dr. Basu A, the team leader at the Oklahoma State University, Stillwater study showed that freeze-dried strawberry supplementation improves blood pressure, impaired glucose, dyslipidemia, or circulating adhesion molecules in obese subjects with metabolic syndrome, thereby lowering cardiovascular risk factors in these subjects suggested.

The randomized controlled trial included 27 subjects with metabolic syndrome (2 males and 25 females; body mass index, 37.5 +/- 2.15 kg/m(2); age, 47.0 +/- 3.0 years [means +/- SE]) consumed 4 cups of freeze-dried strawberry beverage (50 g freeze-dried strawberries approximately 3 cups fresh strawberries) or equivalent amounts of fluids (controls, 4 cups of water) daily for 8 weeks.

Strawberry supplementation intake significantly decreased total and low-density lipoprotein cholesterol (5.8 +/- 0.2 to 5.2 +/- 0.2 mmol/L and 3.5 +/- 0.2 to 3.1 +/- 0.1 mmol/L, respectively [means +/- SE], P < .05) and low-density lipoprotein particles compared to controls at the week 8.

Furthermore, strawberry supplementation also decreased circulating levels of vascular cell adhesion molecule-1 vs controls at the end of the study.


The team at the final report said, "short-term freeze-dried strawberry supplementation improved selected atherosclerotic risk factors, including dyslipidemia and circulating adhesion molecules in subjects with metabolic syndrome".


In additional examing the therapeutic roles of strawberries, blueberries, and cranberries in metabolic syndrome, a prediabetic state characterized by several cardiovascular risk factors, Dr. Basu A said, "strawberries lowering total and LDL-cholesterol, but not triglycerides, and decreasing surrogate biomarkers of atherosclerosis (malondialdehyde and adhesion molecules)".

Strawberry also extended a lowering systolic and diastolic blood pressure and lipid oxidation and improving insulin resistance but in the lesser effect compared to the blueberry

Cranberry juice selectively decreasing biomarkers of lipid oxidation (oxidized LDL) and inflammation (adhesion molecules) in metabolic syndrome compared to lesser effect in those of strawberry.

The tested berries demonstrated a potential effect in up-regulation of endothelial nitric oxide synthase activity in the protection of the cardiovascular system, reduction of renal oxidative damage, and inhibition of the activity of carbohydrate digestive enzymes or angiotensin-converting enzyme in controlling the blood pressure by regulating the volume of fluids in the blood.

Taken all together, strawberry may be considered a function\al food for the prevention of atherosclerosis and combined with the primary therapy for the treatment of the disease.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Reference
(1) The strawberry: composition, nutritional quality, and impact on human health. by Giampieri F, Tulipani S, Alvarez-Suarez JM, Quiles JL, Mezzetti B, Battino M.(PubMed)
(2) Phenolic Composition of Strawberry Genotypes at Different Maturation Stages(ACS Publication)
(3) Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome.
Basu A, Fu DX, Wilkinson M, Simmons B, Wu M, Betts NM, Du M, Lyons TJ.(PubMed)
(4) Strawberries, Blueberries, and Cranberries in the Metabolic Syndrome: Clinical Perspectives.
Basu A, Lyons TJ.(PubMed)
(5) Effects of diet and lifestyle changes on atherosclerotic risk factors after 24 weeks on the Indian Diet Heart Study by Singh RB1, Singh NK, Rastogi SS, Mani UV, Niaz MA. (PubMed)

The Herbs That Protect Digestive Function Against Gastroesophageal Reflux Disease (GERD)

Gastroesophageal reflux disease (GERD), also known as gastro-oesophageal reflux disease (GORD), gastric reflux disease, or acid reflux disease, is a chronic condition characterized by liquid stomach acid refluxing back up from the stomach into the esophagus, causing heartburn.

According to the study of "Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease." by DeVault KR, Castell DO; American College of Gastroenterology, GERD is defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus.

Most common symptoms are burning sensation in your chest (heartburn), chest pain, regurgitation of food or sour liquid and sensation of a lump in your throat.

In the severe case, people with GERD may experience symptoms of difficulty swallowing, lump in the throat asthma,... and chronic cough.

According to the Assaf Harofeh Medical Center, GERD may also facilitate symptoms of chest pain, similar to those with noncardiac chest pain (NCCP)(5).

The causes of GERD are not fully understood. However, some researchers suggested that obesity, poor diet, lack of physical activity, consumption of tobacco and alcohol, and respiratory diseases are associated with the prevalent risk of the diseases(6).

Properly manage diet such as two meals a day with an intake of only fluids in between, whenever the patient feels hungry or thirsty, is a useful dietary regimen for the management of GERD(7) and avoid foods and beverages that trigger GERD symptoms(8).

Use of proton pump inhibitors (PPIs) may be effective but the long-term application may cause severe side effects.

Types of food to prevent and treat Gastroesophageal reflux disease (GERD)
1. Peppermint
According to the study of the review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.)." by McKay DL, Blumberg JB. posted in PubMed, in vitro, peppermint has significant antimicrobial and antiviral activities, strong antioxidant and antitumor actions, and some antiallergenic potential.

Animal model studies demonstrate a relaxation effect on gastrointestinal (GI) tissue, analgesic and anesthetic effects in the central and peripheral nervous system.

However, human studies of peppermint leaf are limited and clinical trials of peppermint tea are absent.

Adverse reactions to peppermint tea have not been reported, although caution has been urged for peppermint oil therapy in patients with GI reflux, hiatal hernia or kidney stones(1).


2. Ginger
Gingerol, is also known as gingerol, a phytochemical of Flavonoids (polyphenols) found in fresh ginger and in a variety of other plants.

Ginger has been used for thousands of years to enhance the function of digestive system and treat stomach distress including nausea, vomiting, diarrhea and indigestion, acid reflux, motion sickness, dyspepsia, etc. due to its due to its anti-inflammatory, antimicrobial and analgesic properties.

According to the study of " Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori", the methanol extract of ginger rhizome inhibited the growth of all 19 strains in vitro with a minimum inhibitory concentration range of 6.25-50 micrograms/ml.

One fraction of the crude extract, containing the gingerols, was active and inhibited the growth of all HP strains with a MIC range of 0.78 to 12.5 micrograms/ml and with significant activity against the CagA+ strains(2).

Other research of [6]-gingerol, [8]-gingerol, [10]-gingerol, and [6]-shogaol. and it effects in nausea and vomiting found that the efficiency of ginger in reducing nausea and vomiting may be based on a weak inhibitory effect of gingerols and shogaols at cholinergic M (3) receptors and serotonergic 5-HT (3) receptors.

Serotonergic 5-HT (4) receptors, which play a role in gastroduodenal motility, appear not to be involved in the action of these compound. (3)

3. Aloe Vera Juice
According to the study described in article of "Effect Of Orally Consumed Aloe Vera Juice On Gastrointestinal Function in Normal Humans", by Jeffrey Bland, Ph.D. (Linus Pauling Institute of Science & Medicine) involved ten healthy subjects - five men (median age: 42; standard deviation: 14 years), and five women (median age: 32; standard deviation: 5 years), Aloe vera juice injection promoted proper gastrointestinal function through regulating gastrointestinal pH and improved gastrointestinal motility, increased stool specific gravity, and reduced populations of certain fecal micro-organisms, including yeast(4).

4. Mastic Gum
According to the article of "Strategies to Protect Against Potential Bone-Destroying Effects"By Chris D. Meletis, ND, while much of the research on mastic gum revolves around its ability to support the health of patients with ulcers and the ability to inhibit the bacteria H. pylori, has been equally useful in patients with GERD and acid reflux(4).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/16767798
(2) http://www.ncbi.nlm.nih.gov/pubmed/14666666
(3) http://www.ncbi.nlm.nih.gov/pubmed/21305447
(4) http://www.desertharvest.com/physicians/documents/DH127.pdf
(5) Comparison of central and intraesophageal factors between gastroesophageal reflux disease (GERD) patients and those with GERD-related noncardiac chest pain by Shapiro M1, Simantov R, Yair M, Leitman M, Blatt A, Scapa E, Broide E(PubMed)
(6) Epidemiology of gastroesophageal reflux disease, by Rubenstein JH1, Chen JW(PubMed)
(7) An old dietary regimen as a new lifestyle change for Gastro esophageal refluxdisease: A pilot study by Randhawa MA1, Mahfouz SA2, Selim NA2, Yar T3, Gillessen A(PubMed)
(8) Management of gastroesophageal reflux disease: lifestyle modification and alternative approaches by Eherer A1(PubMed)