Fennel, The Natural Free Radical Scavenger, Scientists Find

Fennel may be the next generative functional food with the potency in blocking the overexpression of free radical in the induction of chronic illness, some scientists suggested.

Free radicals are the highly reactive molecules with an unpaired electron that cause oxidation by stealing an electron from other molecules to give rise of a chain activity. Once free radical starts its domino effect, it can not be stopped until two free radical species react with each other to form a stable, non-radical adduct or inhibited by the presence of antioxidants.

Antioxidants, on the other hand, are stable molecules that inhibit oxidation caused by free radicals.

The relationship between free radicals and antioxidant are summarized by Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health ", "A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence application of an external source of antioxidants can assist in coping this oxidative stress".

These explanations suggested that intake of antioxidants from the food sources in the stimulation of antioxidant enzymes in the body are benefits in maintaining good health, However, the doctors continued, "Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years".

Overexpression of free radicals or imbalance of the ratio of free radicals and antioxidants in the body can initiate oxidative stress. A prolonged period of oxidative stress in the human body plays a major part in the development of chronic and degenerative illness such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular and neurodegenerative diseases.

Fennel (Foeniculum vulgare) is a plant species of genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The functional herb has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Fennel is an excellent source of natural antioxidants and contributed to the daily antioxidant diet. The functional food is found to process a free radical scavenging activity, particularly in the application of its phenolic and flavonoid.

In the examine the effects of fennel essential oil in the presence of overexpression of free radicals, researchers found, injection of the oil exerts a strong antioxidant activity in comparison with butyrated hydroxyanisole and butylated hydroxytoluene., however, injection of ethanol and water extracts of fennel showed less effective compared to the essential oil.

Furthermore, in the evaluation of the essential oils of the fruits of three organically grown cultivars of Egyptian fennel (Foeniculum vulgare var. azoricum, Foeniculum vulgare var. dulce and Foeniculum vulgare var. vulgare) in antibacterial and antioxidant effects, researchers showed that all three cultivars contain a great source of trans-Anethole, estragole, fenchone, and limonene.


All phytochemicals demonstrated significant activity in free radical scavenging, in the inhibited lipid peroxidation and metal chelation.

Additional differentiation suggested that essential oils from the azoricum and dulce cultivars were more effective antioxidants than that from the vulgare cultivar and essential oils from 3 species display similar antimicrobial activities against two species of fungi, two species of Gram-negative and two species of Gram-positive bacteria.

More importantly, in the examine the effect of essential oil of fennel (Foeniculum vulgare) lipophilic secondary metabolites, researchers at the Avicenna Tajik State Medical University, discovered that
* The oil exhibited moderate antioxidant activities.

* The antioxidants in the essential oil are found to protect the healthy cells and stimulate the expression of free radical in exerting cytotoxic activity against HeLa (human cervical cancer), Caco-2 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma), CCRF-CEM (human T lymphoblast leukemia) and CEM/ADR5000 (adriamycin resistant leukemia) cancer cell lines;

* The most effective of the IC50 values are between 30-210 mg L-1.

These result suggested essential oil from fennel processed a great source of antioxidants with the function of balancing the ratio of free radicals in the body, thus preventing the initiation of oxidative stress.




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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chemical composition, antimicrobial and antioxidant activities of essential oils from organically cultivated fennel cultivars by Shahat AA1, Ibrahim AY, Hendawy SF, Omer EA, Hammouda FM, Abdel-Rahman FH, Saleh MA(PubMed)
(3) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M8(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)

Herbal Catnip Essential Oil, The Natural Antibiotic Alternative with No Side Effects

Herbal catnip was found to process certain chemical compounds which stimulate the immune function against microbial organisms in the acute and chronic phase of infection, some scientists suggested.

In human, anti-microbial activity is a natural reaction in which the macrophages of the immune system in the response to the early phase of infection stimulate the production of inflammatory cytokines which have a unique function in killing off foreign pathogens before they can cause harm to the body.

In plants, antimicrobial substances produced by the plant are served as plant defense mechanisms against predation by microorganisms.


However, overproduction of proinflammatory cytokines in many cases can mistakenly cause damage of healthy cells and tissue in the site of infection, leading to abnormal skin and scars formation.


There are 2 types of inflammatory cytokines: the proinflammatory (Isuch as IL-1β, IL-6. and TNF-α) and anti-inflammatory (such as IL-4, IL-6, IL-10, and IL-11) cytokines. Some cytokines process a duo inflammatory (such as IL-6) functions, under normal conditions, they act as the anti-inflammatory agents to protect against inflammation. Once they sense the danger to the body, they can quickly switch to pro-inflammatory cytokines.


Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.

The functional herb has been used in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritation, stimulate sweating, promote menstruation, etc..

Ingredients
Besides, having the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.

In the finding of the natural alternatives in replacement of traditional antibiotics with no side effects, researchers at the Shiraz University of Medical Sciences launched an evaluation to examine the antimicrobial activity of the essential oil derived from herbal Catnip.


Chemical 4a-α, 7-α, 7a-β-nepetalactone (55-58%), and 4a-α, 7-β, 7a-α-nepetalactone (30-31.2%) isolated from the essential oil were effective in exerting their antimicrobial activity against all tested bacteria at concentrations of 0.125-4 μL/mL and the growth of Candida species at a concentration less than 1 μL/mL.

The essential oil chemical constituent nepetalactones are also found to process anti antibacterial, antifungal, insecticidal and antioxidant activities.


Terpenenes or terpenoids found abundant in Catnip are active against bacteria, fungi, viruses, and protozoa. According to the 1977 report, 60% of essential oil derivatives derived from terpenoids demonstrated inhibition of fungi and while only 30% inhibited bacteria.
Furthermore, the extract of catnip also displayed inhibitory activity on growth, enzyme production and adhesion of some bacteria.


Moreover, the essential oil extract from Catnip also exhibited the anti bactericidal activity against Gram-positive bacteria at concentrations ranging from 0.5 to 8 μL/mL.


All of the Gram-negative bacteria were susceptible to the Catnip oils at concentrations of 0.25–32 μL/mL

The essential oil of Catnip from different growth stages exhibited bacteriostatic and bactericidal activities against the Shigella and Salmonella species at concentrations of 0.25–2 μL/mL and 0.5–8 μL/mL, respectively.


Additionally, the essential oil inhibited the growth of the standard species of Aspergillus at a concentration of 0.25–1 μL/mL.


In the comparison of the antibacterial effect of some herbs, including Catnip, researchers found that Lavender oil is more effective in the exhibited antibacterial ability than the Catnip essential oil, probably based on the concept of synergistic values of essential oil components.


Nevertheless, only a few published reports are available regarding the antimicrobial effects of the catnip EOs, especially against food-borne and resistant microorganisms, Dr. Zomorodian K, the lead author suggested.

Taken altogether, the essential oil derived from catnip may be considered an adjunct therapy for treatment of microbial infection.

Today, mainstream medicine antibiotics have become less effective as many viral and bacteria have developed resistance to the application due to being overused.

Secondary metabolites of plants processed antimicrobial properties with no side effects have been promoted by some companies as natural alternatives to antibiotics. The general public must be aware that many of these compounds are currently available as unregulated botanical preparations.

Please make sure that you follow the guideline of the product closely, as acute liver toxicity has been reported in some cases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chemical Composition and Antimicrobial Activities of Essential Oils from Nepeta cataria L. against Common Causes of Food-Borne Infections by Kamiar Zomorodian, Mohammad Jamal Saharkhiz, Samaneh Shariati, Keyvan Pakshir, Mohammad Javad Rahimi, and Reza Khashei(PubMed)
(2) Effects of Nepeta menthoides aqueous extract on retention and retrieval of memory in mice by Sarahroodi S, Jafari-Najafi R, Nasri S, Rohampour K, Maleki-Jamshid A, Esmaeili S.(PubMed)

Green Tea and Its Bioactive Polyphenols Inhibit Alpha1-Antitrypsin (AAT) Deficiency Against the Onset of Fibromyalgia

Green tea may have a therapeutic and positive effect in reducing onset. progression and treatment of Alpha1-Antitrypsin (AAT) deficiency in the induced fibromyalgia, some scientists suggested.

Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people the in the US alone.

Serum of alpha1-Antitrypsin (AAT) impregnated in most parts of body circulates in our body in high concentrations with function in the inhibition of the enzymes of inflammatory cells.

Alpha1-Antitrypsin (AAT) deficiency is a genetic disorder inherited from the parent characterized by of the inability of the body to produce a protein called alpha-1 anti-trypsin (AAT), leading to inflammation of fatty tissue under the skin (subcutaneous), and at other parts of the body, including the joints, the major cause of fibromyalgia.

Additionally, deficiency of AAT enynes also can cause the liver and lung damage, leading to poor function of the organ and increasing the risk of cirrhosis, COPD, liver and lung cancer.

Although the deficiency is presented since birth, most patients with mutated gene do not experience any symptoms until the age of 50 or 60.



According to the statistic, AAT deficiency is one of the most common inherited disorders among Caucasian compared to other race groups.


Approximately over 1% of patients diagnosed with chronic obstructive pulmonary disease (COPD) processes the alpha1-antitrypsin deficiency gene

In the study of the effect of serum of alpha1-Antitrypsin (AAT) and risk of fibromyalgia (FM), researchers at the Hospital Valle del Nalón found that deficiency of AAT has been found in numbers of patients with fibromyalgia (FM) with severe hereditary.

Functional magnetic resonance imaging of these patients revealed significantly greater activity in pain-sensitive areas of the brain in response to cutaneous stimuli, which may be another evidence for a physiological explanation for FM pain.

Furthermore, patients with FM also were found to consist of abnormal profiles of inflammation markers in biopsies analysis.

The results suggested that these patients may have an imbalance level of pro-inflammatory and anti-inflammatory substances, in the soft body tissues caused by alpha1-Antitrypsin (AAT) deficiency.

Due to surprising findings, Dr. Blanco LE, the lead author, after taking into account of other confounders, said, "identification of genetic, familial, and environmental risk factors suspected to participate in the FM syndrome development (may be necessary) to determine the gene frequency of AAT deficiency alleles in FM patients".

Green tea, bioactive polyphenols EGCG, according to the Dr Helieh S in animal model induced by alpha1-Antitrypsin (AAT) (α1-antitrypsin) deficiency exerted a significant anti-inflammatory effect in inhibited the PI3K/Akt signalling pathway with function in activated proinflammatory factors through the innate immune response involved in pathogen killing, antigen processing and immune cell survival.

Moreover, green tea EGCG application also enhanced antioxidant activity not only through its antioxidant profiles but also stimulated the production of the body natural antioxidants in reduced inflammatory response through nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression, observed by Griess reagent and western blotting.

The evidence indicated that green tea EGCG may have a profound effect in reducing serum alpha1-Antitrypsin (AAT) deficiency in initiated the onset of fibromyalgia

The above differentiations were supported by the review of Chronic Inflammatory Diseases and Green Tea Polyphenol, by Dr. Helieh S. Oz at the University of Kentucky Medical Center.

According to the authors, green tea polyphenols are potent antioxidants with important roles in regulating vital signaling pathways in activated inflammatory responses by attenuating nuclear factor (NF)-kappaB IKK, NF-κB in facilitated innate- and adaptive immune responses, cell death and inflammation and cytokines like TNFα, inflammatory markers and cyclooxygenase-2 in elevated symptoms of inflammation and pain.

Dr. Helieh S. in the summary said, "green tea polyphenols (GrTPs) are potent antioxidants with important roles in regulating vital signaling pathways" and "these comprise transcription nuclear factor-kappa B mediated I kappa B kinase complex pathways, programmed cell death pathways like caspases and B-cell lymphoma-2 (through regulating the cytochrome c release from the mitochondria) and intervention with the surge of inflammatory markers like cytokines and production of cyclooxygenase-2"".

Taken together, green tea and its bioactive polyphenols may be considered as a functional food in ameliorated serum alpha1-Antitrypsin (AAT) deficiency effect in initiated the onset of fibromyalgia. However, intake of green tea supplement should be taken with extreme care due to recent medical reports of acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) alpha1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia by Blanco LE1, de Serres FJ, Fernańdez-Bustillo E, Kassam DA, Arbesú D, Rodríguez C, Torre JC. (PubMed)
(3) Chronic Inflammatory Diseases and Green Tea Polyphenols by Helieh S. Oz(PubMed Central Canada)

Honey, the Potential Chemo Replacement for the Treatment Cancers, Scientists Say

Honey may process certain chemical compounds which have a potential effect in the reducing risk and treatment of cancers with no side effects, some scientists suggested.

Cancer cells are the type of cells which can grow indefinitely compared to normal cycle which can only survive after certain cycle division.

According to cellular biology, in a fully grown adult cell, the rate of cell proliferation is much less, and under normal circumstances and cell division in an adult can only occur when there is the need to replace cells that have been lost, damaged, or worn out.

Most cancers start in the cells on the surface of the inner lining of the tissue of the specific organ.

At the early stage, most cancer tumors do not induce any symptoms. However, after colonizing most tissue, the disorderly proliferative tumor can suppress the nearby tissue including nerve cells and blood vessel, causing localized pain and severe symptoms depending on the types of cancer.

Also, at this stage, malignant cells can also travel through lymph and blood to infect other healthy tissue, a distance away from the original site.

Although there are many risk factor associated with the onset of cancer, people with a genetic preposition are at highest risk.

Men who carry genetic mutation BRCA1, BRCA2, and HOXB13, inherited from the parents are at 70% risk of the prostate cancer, and women who carry the mutated genes BRCA1 and 2 have an increased risk breast cancer of over 55%.

Sadly, more than 12 percent of men with prostate cancer tested positive for hereditary mutations of cancer-causing genes, 87% of women reported BRCA testing by one-year post-diagnosis of breast cancer.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find a natural ingredient for the prevention and treatment of cancer with no side effects, a joint study led by the Universiti Sains Malaysia was conducted to examine the role of honey in modulating the development and progression of tumors or cancers.



By searching the available data online literature, researchers found that there is available evidence (some of which is very recent) with regards to the antimetastatic, antiproliferative and anticancer effects of honey in various forms of cancer.

Honey was highly cytotoxic against tumor or cancer cells, while it was non-cytotoxic to normal cells.

Honey inhibited growth and proliferation of tumors or cancers.

Application of honey inhibited carcinogenesis by modulating the molecular processes of initiation, promotion, and progression stages.


Furthermore, in the study to examine the honey and royal jelly effects against cisplatin-induced nephrotoxicity in patients with cancer, researchers examined the results of patients with cancer assigned for cisplatin chemotherapy randomly divided into bee honey and royal jelly groups pretreated before the initiation and during cisplatin chemotherapeutic regimen and control group on cisplatin only and showed that* Patients on crude bee honey and royal jelly capsules showed lower serum levels of renal injury products (creatinine and urea) compared to those in the control group.

* The changes in kidney parameters were significantly (p < 0.05) lower when compared within the bee honey group before and after cisplatin treatment.



These results indicated bee honey and royal jelly as natural compounds are effective in reducing cisplatin nephrotoxicity and may offer a promising chance for clinically meaningful prevention with no side effects.


Interestingly, Dr. the lead author in the examine the overwhelming evidence of the role of diet and lifestyle in cancer risk and prevention, suggested that there is a growing interest into the search for chemopreventative or chemotherapeutic agents derived from natural products.


And, honey is an important source of bioactive compounds derived from plants and recent years have been under the intensified study for its anticancer properties.


Recently, the role of honey in targeting key hallmarks of carcinogenesis, including uncontrolled proliferation, apoptosis evasion, angiogenesis, growth factor signaling, invasion, and inflammation has been presented. in numbers of conventional research.


Taken altogether, honey may be used as a functional food for the prevention of cancers and a secondary therapy combined with conventional medicine for the treatment of cancers.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Effects of honey and its mechanisms of action on the development and progression of cancer by Erejuwa OO1, Sulaiman SA2, Wahab MS. (PubMed)
(2) Effect of Honey and Royal Jelly against Cisplatin-Induced Nephrotoxicity in Patients with Cancer by Osama H1, Abdullah A1, Gamal B1, Emad D1, Sayed D1, Hussein E1, Mahfouz E1, Tharwat J1, Sayed S1, Medhat S1, Bahaa T1, Abdelrahim MEA. (PubMed)
(3) Honey and Cancer: Current Status and Future Directions by Porcza LM1, Simms C2, Chopra M. (PubMed)

Banana, The Potential Gastric Ulcer Healing Functional Food

Banana may have a potential effect in protecting the gastrointestinal tract against the formation of gastric ulcers, some scientists suggested.

Gastric ulcers are open sores that develop on the inside lining of your stomach.


The most common cause of gastric ulcer is associated with the infection of the bacterium Helicobacter pylori (H. pylori). However, patients who are the long-term users of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) also at a higher risk of gastric ulcer.


Long-term untreated gastric ulcer can result in gastric adenocarcinoma development.

Although there are some disagreements that a poor diet can cause gastric ulcers, some researchers suggested that a diet rich, fatty or spicy foods such as the Western diet and unhealthy lifestyle such as high caffeine. and excessive alcohol consumption also elevates the onset of the disease.


Therefore by following a healthy diet with more fruits and vegetable, whole grain less red meat and processed foods accompanied by a healthy choice of lifestyle and moderate exercise, one can lower the risk gastric ulcer substantially.


Dr. the lead author in the study, "Nutritional care in peptic ulcer" wrote, "Dietotherapy, as well as caloric distribution, should be adjusted to the patient's needs aiming to normalize the nutritional status and promote healing. Recommended nutrients can be different in the acute phase and in the recovery phase, and there is a greater need of protein and some micronutrients, such as vitamin A, zinc, selenium, and vitamin C in the recovery phase. In addition, some studies have shown that vitamin C has a beneficial effect on the eradication of H. pylori. Fibers and probiotics also play an important role in the treatment of peptic ulcer, because they reduce the side effects of antibiotics and help reduce treatment time.".

These results suggested that gastric ulcer not only can be prevented by the change of diet but can also be treated by modifying the antioxidant and nutrients intake.


Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belongs to the family of the lily and the orchid.

The Banaras Hindu University in the reaffirming the inflammatory cytokines expression occurred in the onset of gastric ulcer onset launched an investigation to examine the effect of a Musa sapientum fruit (banana extract, MSE) extract the acetic acid (AA)-induced gastric ulcer (GU) in diabetic (DR) rat.

Selected rat model were given MSE (100 mg/kg, oral), omeprazole (OMZ, 2.0 mg/kg, oral), insulin (INS, 4 U/kg, sc) or pentoxyphylline (PTX, 10 mg/kg, oral) once daily for 10 days in 14 days post-streptozotocin (60 mg/kg, intraperitoneal)-induced diabetic rats before the normal/diabetic rats were received CMC for the same period after induction of GU with AA.

According to the ulcer index, TNF-α and IL-1β were observed in normal (NR)-AA rat given the acetic acid (AA) compared to NR-normal rats group.. the expression of proinflammatory presentation suggested that acetic acid (AA) has caused gastric damage.


Application of Musa sapientum fruit (MSE) extract inhibited the gastric ulcer expression through significant normalizing the levels of the blood glucose and gastric mucosal cytokines, TNF-α and IL-1β and growth factor, TGF-α, compared to OMZ (antiulcer drug).

Further analysis suggested that the efficacy of Musa sapientum fruit (MSE) extract was attributed to the presence of phytochemicals saponins, flavonoids, glycosides, steroids, and alkaloids.

Dr. Kumar M, the lead scientists said, "MSE showed antidiabetic and better ulcer healing effects compared with OMZ (anti-ulcer drug)".


Additionally, in the study of the antiulcer and mucosal defensive factors effects of methanolic extract of Musa sapientum var. Paradisiaca (MSE, 100 mg/kg) in normal and non-insulin dependent diabetes mellitus (NIDDM) rats. NIDDM was induced by administering streptozotocin (STZ, 70 mg/kg, ip) to 5 days old rat pups also found that

* The effects of MSE were effective compared with the known ulcer protective drug, sucralfate (SFT, 500 mg/kg) and anti-diabetic drug glibenclamide (GLC, 0.6 mg/kg) when administered orally, once daily for 6 days against gastric ulcers (GU).

* The MSE extracts reverse the changes in gastric mucosal glycoproteins, cell proliferation, free radicals (lipid peroxidation and nitric oxide) and anti-oxidants enzymes (superoxide dismutase and catalase) and glutathione (GSH) levels induced by administering streptozotocin.

* MSE showed better ulcer protective effect in NIDDM rats compared with SFT and GLC in CRS-induced GU

* The extracts restore the levels of the gastric mucosal glycoprotein which was reduced in the NIDDM rats without having any effect on cell proliferation.

* MSE pretreatment showed a reversal in the levels of all the parameters better than GLC.caused by the injection of streptozotocin.

Final differentiation discovered that the efficacy of MSE in the inhibition of gastric ulcers was attributed to the predominant effect on the mucosal glycoprotein, cell proliferation, free radicals, and antioxidant systems.


Taken all together, banana processed abundantly phytochemicals may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for the treatment of gastric ulcer without inducing any side effects.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Healing effects of Musa sapientum var. paradisiaca in diabetic rats with co-occurring gastric ulcer: cytokines and growth factor by PCR amplification by Kumar M, Gautam MK, Singh A, Goel RK1.(PubMed)
(2) Effect of plantain banana on gastric ulceration in NIDDM rats: the role of gastric mucosal glycoproteins, cell proliferation, antioxidants and free radicals by Mohan Kumar M1, Joshi MC, Prabha T, Dorababu M, Goel RK. (PubMed)
(3) Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer. by Prabha P1, Karpagam T, Varalakshmi B, Packiavathy AS.(PubMed)

Herbal Cascara Sagrada's Emodin, the Anti Breast Cancer Bioactive Compound

Scientists may have found a natural ingredient isolated from a herbal plant which processes a significant effect in reducing risk and treatment of breast cancer, some studies suggested.

Breast cancer (malignant breast neoplasm) is a medical and chronic condition characterized by irregular cells growth in the breast tissue.

Most cases of breast cancer start either in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

There are also rare cases of breast cancer that start in other areas of the breast

The cause of breast cancer is the result of the alternation of DNA of the cells in the breast.

According to statistic, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the US alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Genetic preposition, one of the prevalent risk factor associated with the increased risk of breast cancer has been under intensifying study in scientists over the world over a few decades ago, suggested that women who carry the mutated genes BRCA1 and 2 have 60% most likely risk to develop breast cancer before the age of 70.


Another prevalent and most mentioned risk factor associated with the risk of the disease is obesity.


Dr. Manuel Picon‐Ruiz, the lead author, in the concern of the correlated increased incidence of breast cancer among obese women launched an investigation to examine whether obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages.

After taking into account co and confounder, the doctors wrote, "The Million Women Study followed 1.2 million UK women ages 50 to 64 years for a mean of 5.4 years, including 45,037 with breast cancer, and identified a nearly 30% higher risk of developing postmenopausal breast cancer with obesity". and "(But) a large body of evidence indicates that, although obesity is inversely associated with receptor‐positive breast cancer development before menopause"

Interestingly, the results strongly indicated, obesity is a risk factor of breast cancer in postmenopause but a reduced risk factor before menopause.

Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.

The herbal plant bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.


Besides the main compound of anthraquinones, the herb also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.

In the finding a natural compound or whole food which process the potency for the treatment of breast cancer with little or no side effects compared to those of conventional chemo drug, researchers conducted a joint study led by the China Medical University to examine the anti-breast cancer effect of Emodin.

Human breast cancer cells Bcap-37 and ZR-75-30.were used in the study

The cell viability following emodin treatment was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.

Application of Emodin showed a strong effect in the inhibition of the growth and induction of apoptosis of breast cancer cells Bcap-37 and ZR-75-30 in a time- and dose-dependent manner.

The inhibitory activity was attributed to Emodin in reducing the level of a protein associated with inhibiting apoptosis and promoting oncogenesis, and proteins and antibodies associated with programming cell death and enhancing apoptosis.

Dr. CONG ZU the lead scientist, after taking into account co and confounders said, "These findings indicate that emodin induces growth inhibition and apoptosis in human breast cancer cells. Emodin may be a potential therapeutic agent for the treatment of breast cancer".

In mice bearing EO771 or 4T1 breast tumors, researchers at the University of South Carolina School of Medicine examine the effects of Emodin against breast cancer through varied mechanisms.

Application of Emodin showed a significant effect in the attenuation tumor growth by inhibiting macrophage infiltration and M2-like polarization, in promoting cancer cell growth, invasion, metastasis and accompanied by increased immune white blood cells in the host and reduced the new formation of blood vessels for the cancer proliferation.

The inhibition of the promotion of cancer cell growth, invasion, metastasis by emodin was associated with deactivation of genes on the promoters of M2-related genes in tumor-associated macrophages.

Dr. Iwanowycz S, at the final report, "emodin acts on both breast cancer cells and macrophages and effectively blocks the tumor-promoting feedforward loop between the two cell types, thereby inhibiting breast cancer growth and metastasis".

Taken altogether, Herbal Cascara Sagrada processed abundant bioactive compound Emodin may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of breast cancer.



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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Emodin induces apoptosis of human breast cancer cells by modulating the expression of apoptosis-related genes by CONG ZU,1,* MINGDI ZHANG,2,* HUI XUE,3 XIAOPENG CAI,4 LEI ZHAO,5 ANNING HE,1GUANGYUAN QIN,1 CHUNSHU YANG,1 and XINYU ZHENG. (PMC)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., 1 Cynthia Morata‐Tarifa, PhD, 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, Ph.D. (PMC)
(3) Emodin Inhibits Breast Cancer Growth by Blocking the Tumor-Promoting Feedforward Loop between Cancer Cells and Macrophages by Iwanowycz S1, Wang J1, Hodge J1, Wang Y1, Yu F2, Fan D. (PubMed).

Ginger, the Heart and Blood Vessels Friendly Functional Spice

Ginger may have a profound and positive effect in reducing the risk and treatment of cardiovascular disease, some studies found.

The cardiovascular disease is a medical condition associated with the heart and blood vessels, depending on the location of blood clots.

Most common causes of cardiovascular disease are atherosclerosis caused by plaque accumulated on the wall of the arteries, leading to reduced rich oxygenated blood flow to the heart, a major cause of the death of heart cells.

According to the John Hopkins statistics, approximately 84 million people in the US suffer from some form of cardiovascular disease, causing about 2,200 deaths a day, averaging one death every 40 seconds.

Sadly to know that almost one out of every three deaths results from cardiovascular disease.

Epidemiologically, certain risk factors are found to associate with the onset of the condition, including lack of exercise, diabetes, use of tobacco, gender, genetic preposition, and excessive alcohol drinking.

However, poor diet was one of the preventable risk factors in the Western world. Researchers suggested that there is no coincidence but a correlation of the widespread cardiovascular disease in the US and the promotion of the Western diet over the past many decades.

Diet high in saturated and trans fat, red meat and processed food and few in fruits and vegetables and whole grain have a strong and positive implication in the promotion of the onset of the disease.

Dr. Sonia S. Anand, the lead scientist in the study "Food Consumption and its impact on Cardiovascular Disease: Importance of Solutions focused on the globalized food system" said, "Evidence from different countries, age/race/ethnicity/socioeconomic groups suggest the health effects studies of foods, macronutrients, and dietary patterns on CVD appear to be far more consistent though regional knowledge gaps are highlighted".

And, "Poor quality diets are high in refined grains and added sugars, salt, unhealthy fats, and animal-source foods; and low in whole grains, fruits, vegetables, legumes, fish and nuts ( are associated to the onset of CVD)"

Therefore, by teaching the general public the role of diet that can prevent CVD, the writers continued, "a healthier food supply enables individuals to make healthier choices. Developing food systems that underpin healthier dietary patterns based on our consensus noted above involves improving the food supply by producing more heart-healthy foods and fewer foods associated with CVD".

These results clearly stated, a healthy diet with high in fruits and vegetable, whole grain fewer saturated and trans fat, red meat and processed foods can substantially reduce the risk of CVD.


Ginger officinale or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to reconfirm the effects of ginger for the treatment of many aspects of cardiovascular disease, Dr. Nicoll R and colleagues conducted a study to look into ginger anti-cardiovascular disease activity.

In the animal model, application of ginger demonstrated a significant anti-inflammatory, antioxidant, antiplatelet, hypotensive and hypolipidemic effect to protect the tested animal against the onset of cardiovascular disease.



In the human trial, dosages of 5 g or more demonstrated significant antiplatelet activity.


These results suggested that ginger may have the potential to offer not only a cheaper natural alternative to conventional agents but one with significantly lower side effects.


Futhermore in the concern of the widespread of cardiovascular diseases in the Western world and the leading cause of death worldwide, researchers at the Katedra Technologii Żywienia Człowieka evaluated the effects of kitchen spice on the condition.

Ginger and the selected spices showed a strongly cardioprotective effect through their antioxidant, chemopreventive, anti-inflammatory and immunomodulatory properties.

At the final report of the study, Dr. Kulczyński B, said, "selected spices (garlic, cinnamon, ginger, coriander, and turmeric) (may be used )in the prevention and treatment of cardiovascular diseases".

Taken altogether, ginger may be considered a functional food for the prevention and combined with the primary medicine for the treatment of cardiovascular disease with no side effects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Ginger (Zingiber officinale Roscoe): a hot remedy for cardiovascular disease? by Nicoll R, Henein MY. (PubMed)
(2) The importance of selected spices in cardiovascular diseases by Kulczyński B1, Gramza-Michałowska A. (PubMed)
(3) Spices and Atherosclerosis by Tsui PF1,2, Lin CS3, Ho LJ4, Lai JH. (PubMed)
(4) Food Consumption and its impact on Cardiovascular Disease: Importance of Solutions focused on the globalized food system. A Report from the Workshop convened by the World Heart Federation by Sonia S. Anand,1,2,* Corinna Hawkes,3,* Russell J. de Souza,4 Andrew Mente,2Mahshid Dehghan,2 Rachel Nugent,5 Michael A. Zulyniak,1 Tony Weis,6 Adam M. Bernstein,7Ronald Krauss,8 Daan Kromhout,9 David J.A. Jenkins,10,11 Vasanti Malik,12Miguel A. Martinez-Gonzalez,13 Dariush Mozafarrian,14 Salim Yusuf,2 Walter C. Willett,12 andBarry M Popkin. (PMC)