Friday, April 5, 2019
Strawberry Effects on Human Type 1 Allergy
The antigen is a toxin or other foreign pathogens that induce an immune response in the body, by stimulating the production of antibodies IgE.
According to the statistic, approximately 50 million Americans each year suffer from an allergy-related disease or condition. and the syndrome is a sixth leading cause of chronic illness in the US.
Epidemiological studies suggested that people with certain medical conditions such as asthma, family history of allergy and asthma and are younger than the age of 18 are at the increased risk of allergy.
Food allergies of type I which are mediated by food-specific IgE antibodies by signaling the release of histamine from the mast cells upon the contact with the relevant allergen, causing symptoms of skin, nose, throat, and lung irritation.
The genetic proposition is also one of the prevalent risk factors for allergic onset. Dr. Romina A. Ortiz, the lead author in the examine the genetic risk in allergic diseases, wrote, "The allergic diseases are complex phenotypes for which a strong genetic basis has been firmly established" and "A major outcome of Genome-wide association studies (GWAS) in allergic disease has been the formation of national and international collaborations leading to consortia meta-analyses, and an appreciation for the specificity of genetic associations to sub-phenotypes of allergic disease".
The genes which have a potential cause of the allergic disease include ORMDL3 locus with childhood asthma and generalizability of FLG mutations with allergic diathesis.,...
Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
On finding potential and natural whole food for the prevention and treatment of type 1 allergy with no side effects, scientists at the Gifu University evaluated the anti-allergic activity of chemical constituents isolated from the strawberry.
Linocinnamarin (LN), 1-O-trans-cinnamoyl-beta-d-glucopyranose (CG), and cinnamic acid (CA) from the fruit were found to exert a significant effect against exhibited antigen (Ag) in stimulating the cellular process that releases antimicrobial cytotoxicity in rat basophilic leukemia RBL-2H3 cells.
On cellular responses induced by antigen stimulation, LN and CA markedly inhibited antigen-stimulated the elevation of intracellular free Ca(2+) concentration which plays an important role in T cell activation and reactive oxygen species (ROS).
The results were associated with the suppression of the Ag-stimulated spleen tyrosine kinase (Syk) activation that mediates immune receptors associated with antibody and antigen.
Further analysis of the efficacy of LN and CA, researchers discovered that the inhibition of antigen-by LN and CA is mainly due to inactivation of Syk/phospholipase Cgamma (PLCgamma) pathways which control both the innate and adaptive immune systems.
Dr. Ninomiya M, said in the final report, "LN and CA isolated from F. ananassa Duch. (strawberry) could be beneficial agents for alleviating symptoms of type I allergy".
Other bioactive compounds isolated from strawberry including isolated the 4 kinds of flavonoids from strawberry 'Nohime' also were found to exert similar effects on the cellular process that releases antimicrobial cytotoxicity in RBL-2H3 cells in the Gifu International Institute of Biotechnology study.
The found flavonoids demonstrated a strong effect on the intracellular free Ca(2+) concentration ([Ca(2+)]i) and PLCgammas similar to those of the above study.
Treatment of flavonoids also displayed a strong effect on the intracellular signaling pathway associated with the regulation of immune cell function.
Dr. Itoh T, the lead author at the end of the experiment wrote, " suppression of Ag-stimulated degranulation by the flavonoids is mainly due to suppression of [Ca(2+)]i elevation and Syk activation".
Taken altogether, strawberry, the tasty fruit processed high amounts of bioactive compounds may be considered a function fruit for the prevention and treatment of type 1 allergy with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Genetics of Allergic Diseases by Romina A. Ortiz, MS and Kathleen C. Barnes, Ph.D. (PMC)
(2) Phenolic constituents isolated from Fragaria ananassa Duch. inhibit antigen-stimulated degranulation through direct inhibition of spleen tyrosine kinase activation by Ninomiya M, Itoh T, Ishikawa S, Saiki M, Narumiya K, Yasuda M, Koshikawa K, Nozawa Y, Koketsu M.(PubMed)
(3) Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 by Itoh T, Ninomiya M, Yasuda M, Koshikawa K, Deyashiki Y, Nozawa Y, Akao Y, Koketsu M.(PubMed)
Tualang Honey, The Potential Anti Cervical Cancer Functional Food
Scientists may have located a natural whole food for the prevention and treatment of cervical cancer with no side effects, some studies found.
Cervical cancer is the chronic condition caused cell growth disorderly in the tissue of the cervix.
Most cases of cervical cancer start on the cells in the surface of the inner lining tissue of the cervix.
Most patients at this stage of cervical cancer do not experience any symptoms.
As cancer progresses, most patients may experience the symptoms of blood spots or light bleeding between or following periods, longer than usual and heavy menstrual bleeding, increased vaginal discharge, particularly, bleeding after intercourse, douching.
At this stage, cervical cancer can travel a distance away to cause metastasis to other healthy tissue and organs through fluids and blood circulation.
If you have experienced some of the above symptoms, please check with your doctor to rule out the cervical cancer possibility.
Although certain risk factors such as having many sexual partners, long-term use of birth control pills (oral contraceptives), early engaging in sexual contact are associated with the onset of the disease, Human papillomavirus (HPV) infection is one of major cause that has been under intensive investigation.
Belief or not, there are over 100 different HPV types have been identified and classified as high risk in almost all cervical cancers (>99.7%).
Out of this 100 different HPV, HPV16 is the most prevalent type in both low-grade disease and cervical neoplasia.
Dr. Doorbar J at the National Institute for Medical Research, said, "Most cervical cancers arise within the cervical transformation zone at the squamous/columnar junction, and it has been suggested that this is a site where productive infection may be inefficiently supported"
"Cancers usually arise in individuals who fail to resolve their infection and who retain oncogene expression for years or decades. In most individuals, immune regression eventually leads to clearance of the virus, or to its maintenance in a latent or asymptomatic state in the basal cells".
These results clearly stage, most of the initiation of HPV infection is stopped by the immune system first line of defense before the virus penetrates through the cervical cell membrane on the surface of the inner lining.
In other words, women who have a weakened immune system are at substantial risk to the disease.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient or whole food for the prevention and treatment of cervical cancer, researchers examined the Tualang honey (Agromas) anti-cancer effect.
Tualang honey (Agromas) (TH) were applied with increasing doses of TH (1-10%) for up to 72 h to the human breast (MCF-7 and MDA-MB-231) and cervical (HeLa) cancer cell lines; as well as in the normal breast epithelial cell line, MCF-10A.
At concentrations (EC(50)) of 2.4-2.8%., Tualang honey increased in lactate dehydrogenase (LDH) leakage from the cancer cell membranes, an indication of cytotoxicity to all three cancer cells.
Furthermore, application of TH also reduced the mitochondrial membrane potential (Δψ(m)) in response to energy storage in the cancer cell lines after 24h of treatment.
TH also stimulated the proteins associated with cancer cells apoptosis.
The evidence suggested that TH has significant anticancer activity against human cervical cancer cell lines.
Additionally, in the evaluation of bee bread (BB), a fermented mixture of plant pollen, honey, and bee saliva against HeLa (cervical carcinoma) cancer cells line, researchers found that application of BB displays a moderate activity in the inhibition of the cancer cell line through cytotoxicity with doses ranging from >400 to 68 µg/mL).
The inhibition of the human cervical cancer cell line was attributed to the main phenolic compounds also found abundantly in the Tualang honey.
The in-depth analysis suggested that BB induces HeLa cell death through stimulating the function of free radicals in the induction of oxidative stress to cause cytotoxicity.
Taken altogether, honey or Tualang honey may be considered a functional food for the prevention and combined with the primary therapy for the treatment of cervical cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines by Fauzi AN1, Norazmi MN, Yaacob NS. (PubMed)
(2) Flavonoid Composition and Antitumor Activity of Bee Bread Collected in Northeast Portugal by Sobral F1, Calhelha RC2, Barros L3,4, Dueñas M5, Tomás A6, Santos-Buelga C7, Vilas-Boas M8, Ferreira IC9. (PubMed)
(3) Molecular biology of human papillomavirus infection and cervical cancer by Doorbar J. (PubMed)
Cervical cancer is the chronic condition caused cell growth disorderly in the tissue of the cervix.
Most cases of cervical cancer start on the cells in the surface of the inner lining tissue of the cervix.
Most patients at this stage of cervical cancer do not experience any symptoms.
As cancer progresses, most patients may experience the symptoms of blood spots or light bleeding between or following periods, longer than usual and heavy menstrual bleeding, increased vaginal discharge, particularly, bleeding after intercourse, douching.
At this stage, cervical cancer can travel a distance away to cause metastasis to other healthy tissue and organs through fluids and blood circulation.
If you have experienced some of the above symptoms, please check with your doctor to rule out the cervical cancer possibility.
Although certain risk factors such as having many sexual partners, long-term use of birth control pills (oral contraceptives), early engaging in sexual contact are associated with the onset of the disease, Human papillomavirus (HPV) infection is one of major cause that has been under intensive investigation.
Belief or not, there are over 100 different HPV types have been identified and classified as high risk in almost all cervical cancers (>99.7%).
Out of this 100 different HPV, HPV16 is the most prevalent type in both low-grade disease and cervical neoplasia.
Dr. Doorbar J at the National Institute for Medical Research, said, "Most cervical cancers arise within the cervical transformation zone at the squamous/columnar junction, and it has been suggested that this is a site where productive infection may be inefficiently supported"
"Cancers usually arise in individuals who fail to resolve their infection and who retain oncogene expression for years or decades. In most individuals, immune regression eventually leads to clearance of the virus, or to its maintenance in a latent or asymptomatic state in the basal cells".
These results clearly stage, most of the initiation of HPV infection is stopped by the immune system first line of defense before the virus penetrates through the cervical cell membrane on the surface of the inner lining.
In other words, women who have a weakened immune system are at substantial risk to the disease.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient or whole food for the prevention and treatment of cervical cancer, researchers examined the Tualang honey (Agromas) anti-cancer effect.
Tualang honey (Agromas) (TH) were applied with increasing doses of TH (1-10%) for up to 72 h to the human breast (MCF-7 and MDA-MB-231) and cervical (HeLa) cancer cell lines; as well as in the normal breast epithelial cell line, MCF-10A.
At concentrations (EC(50)) of 2.4-2.8%., Tualang honey increased in lactate dehydrogenase (LDH) leakage from the cancer cell membranes, an indication of cytotoxicity to all three cancer cells.
Furthermore, application of TH also reduced the mitochondrial membrane potential (Δψ(m)) in response to energy storage in the cancer cell lines after 24h of treatment.
TH also stimulated the proteins associated with cancer cells apoptosis.
The evidence suggested that TH has significant anticancer activity against human cervical cancer cell lines.
Additionally, in the evaluation of bee bread (BB), a fermented mixture of plant pollen, honey, and bee saliva against HeLa (cervical carcinoma) cancer cells line, researchers found that application of BB displays a moderate activity in the inhibition of the cancer cell line through cytotoxicity with doses ranging from >400 to 68 µg/mL).
The inhibition of the human cervical cancer cell line was attributed to the main phenolic compounds also found abundantly in the Tualang honey.
The in-depth analysis suggested that BB induces HeLa cell death through stimulating the function of free radicals in the induction of oxidative stress to cause cytotoxicity.
Taken altogether, honey or Tualang honey may be considered a functional food for the prevention and combined with the primary therapy for the treatment of cervical cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines by Fauzi AN1, Norazmi MN, Yaacob NS. (PubMed)
(2) Flavonoid Composition and Antitumor Activity of Bee Bread Collected in Northeast Portugal by Sobral F1, Calhelha RC2, Barros L3,4, Dueñas M5, Tomás A6, Santos-Buelga C7, Vilas-Boas M8, Ferreira IC9. (PubMed)
(3) Molecular biology of human papillomavirus infection and cervical cancer by Doorbar J. (PubMed)
Thursday, April 4, 2019
Phytochemical Triterpenoid Which Inhibits Nonalcoholic Fatty Liver Disease
Nonalcoholic Fatty liver disease (NAFLD) is a condition of the fatty liver diseases as a result of accumulated of fat in the liver over time, not caused by abusive alcohol consumption.
Most patients in the early stage of nonalcoholic fatty liver disease do not experience any symptoms until the disease has advanced to the critical stage.
According to the statistic, NAFLD is the most common cause of liver disease in the Western world.
Most diseases associated with NAFLD are obesity, high blood pressure, diabetes, and high cholesterol.
People with insulin resistant, diabetes, high blood pressure, high blood fat levels and/or the metabolic syndrome, are associated with an increased risk of NAFLD.
Other risk factors on the incidence of NAFLD are the increase in age, ethnicity and family history.
Believe or not, people who carry certain mutated gene also at a higher risk of the disease. Dr. Silvia Sookoian in the concern of the global epidemic risk of Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease wrote, "Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening the long-term prognosis.".
And, " A growing body of evidence indicates that NAFLD develops from a complex process in which many factors, including genetic susceptibility and environmental insults, are involved".
Triterpenoid is various unsaturated hydrocarbons, found in essential oils and oleoresins of plants, including Ilex hainanensis Merr.
On finding a natural ingredient or whole food for the prevention and treatment of non-alcoholic fatty liver disease with no side effects, researchers at the China Pharmaceutical University evaluated the effect of the triterpenoid-rich fraction (TF) from Ilex hainanensis Merr. on NAFLD in an animal model.
The study included Male Sprague-Dawley (SD) rats fed a normal diet (control) or high-fat diet (NAFLD model) 4 four weeks, following by the orally administrated TF (250 mg/kg) for another two weeks.
Before application of TF compound, rats fed a high-fat diet displayed an abnormally high blood cholesterol levels and a decline in liver function compared to control.
Application of TF on these rats not only restores the health issues caused by high-fat diet but also decreased the expression of plasma levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, and the high-density lipoprotein cholesterol.
Levels of alanine transaminase (p < 0.05), aspartate aminotransferase (p < 0.01), liver index (p < 0.05), the indication of liver oxidative stress and insulin resistance index (p < 0.05) were also decreased by TF adminsitration.
Futhermore, TF improved the liver lesions induced by the high-fat diet.
Moreover, TF injection also alleviated oxidative stress and inflammation status indicated by the decline levels of oxidative markers, free radicals, and pro-inflammatory cytokines.
Dr. Cui WX, the lead scientist, after taking into account co and confounders said, "TF has the potential ability to protect the liver against NAFLD by regulating lipids metabolism and alleviating insulin resistance, inflammation and oxidative stress".
Additionally, the study to reconfirm the traditional use of herbal Ilex hainanensis Merr. for the treatment of non-alcoholic fatty liver disease, researchers examine the compound Chlorogenic acid, kaempferol-7-O-β-d-glucoside, and ilexgenin, a novel triterpenoid, the three major bioactive components in I. hainanensis extract.
Compared to normal rats, application of I. hainanensis extract exerted a significant change in NAFLD rats.
The efficacy of the herbal extract was attributed to the anti-NAFLD activity of chlorogenic acid, kaempferol-7-O-β-d-glucoside, and ilexgenin A.
Taken altogether, phytochemical Triterpenoid may be considered a supplement for the prevention and treatment of non-alcoholic fatty disease pending to the large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga,1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(2) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)
(3) Genetic predisposition in nonalcoholic fatty liver disease by bSilvia Sookoian1 and Carlos J. Pirola2(PMC)
Most patients in the early stage of nonalcoholic fatty liver disease do not experience any symptoms until the disease has advanced to the critical stage.
According to the statistic, NAFLD is the most common cause of liver disease in the Western world.
Most diseases associated with NAFLD are obesity, high blood pressure, diabetes, and high cholesterol.
People with insulin resistant, diabetes, high blood pressure, high blood fat levels and/or the metabolic syndrome, are associated with an increased risk of NAFLD.
Other risk factors on the incidence of NAFLD are the increase in age, ethnicity and family history.
Believe or not, people who carry certain mutated gene also at a higher risk of the disease. Dr. Silvia Sookoian in the concern of the global epidemic risk of Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease wrote, "Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening the long-term prognosis.".
And, " A growing body of evidence indicates that NAFLD develops from a complex process in which many factors, including genetic susceptibility and environmental insults, are involved".
Triterpenoid is various unsaturated hydrocarbons, found in essential oils and oleoresins of plants, including Ilex hainanensis Merr.
On finding a natural ingredient or whole food for the prevention and treatment of non-alcoholic fatty liver disease with no side effects, researchers at the China Pharmaceutical University evaluated the effect of the triterpenoid-rich fraction (TF) from Ilex hainanensis Merr. on NAFLD in an animal model.
The study included Male Sprague-Dawley (SD) rats fed a normal diet (control) or high-fat diet (NAFLD model) 4 four weeks, following by the orally administrated TF (250 mg/kg) for another two weeks.
Before application of TF compound, rats fed a high-fat diet displayed an abnormally high blood cholesterol levels and a decline in liver function compared to control.
Application of TF on these rats not only restores the health issues caused by high-fat diet but also decreased the expression of plasma levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, and the high-density lipoprotein cholesterol.
Levels of alanine transaminase (p < 0.05), aspartate aminotransferase (p < 0.01), liver index (p < 0.05), the indication of liver oxidative stress and insulin resistance index (p < 0.05) were also decreased by TF adminsitration.
Futhermore, TF improved the liver lesions induced by the high-fat diet.
Moreover, TF injection also alleviated oxidative stress and inflammation status indicated by the decline levels of oxidative markers, free radicals, and pro-inflammatory cytokines.
Dr. Cui WX, the lead scientist, after taking into account co and confounders said, "TF has the potential ability to protect the liver against NAFLD by regulating lipids metabolism and alleviating insulin resistance, inflammation and oxidative stress".
Additionally, the study to reconfirm the traditional use of herbal Ilex hainanensis Merr. for the treatment of non-alcoholic fatty liver disease, researchers examine the compound Chlorogenic acid, kaempferol-7-O-β-d-glucoside, and ilexgenin, a novel triterpenoid, the three major bioactive components in I. hainanensis extract.
Compared to normal rats, application of I. hainanensis extract exerted a significant change in NAFLD rats.
The efficacy of the herbal extract was attributed to the anti-NAFLD activity of chlorogenic acid, kaempferol-7-O-β-d-glucoside, and ilexgenin A.
Taken altogether, phytochemical Triterpenoid may be considered a supplement for the prevention and treatment of non-alcoholic fatty disease pending to the large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga,1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(2) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)
(3) Genetic predisposition in nonalcoholic fatty liver disease by bSilvia Sookoian1 and Carlos J. Pirola2(PMC)
Anacardic Acid, A Bioactive Ingredient Which Processes Anti Lung Cancer Potential
Anacardic acids may be considered a bioactive ingredient for the prevention and treatment of lung cancer, some scientists found.
Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. Most cases of primary lung cancer start in the cells on the surface of the inner lining of lung tissue.
At the early stage, most patients do not experience any symptoms. However, as cancer continues to advance, it can put pressure on the nearby healthy tissue such as blood vessel and nerve cell, leading to localized symptoms and severe pain.
At the later stage, lung cancells can also travel through blood and fluids circulation to infect other healthy tissue and organ, leading to secondary metastasis.
According to the 2007 statistic, the most common form of primary lung cancers is derived from epithelial cells. In the US, lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women.
The most common form of lung cancer metastasis is brain cancer, according to the statistic, approximately, 40 percent of people with advanced lung cancer will develop brain cancer sometimes during the disease.
The causes of lung cancer are unknown. However, epidemiologically suggested that although there are many risk factors associated with the onset of lung cancers, smoking tobacco, and second-hand smoke are considered the most risk of the diseases.
Other risk factors include radon asbestos, occupational exposure to certain chemicals, outdoor air pollution, personal or family history of lung cancer, personal history of lung disease and long-term exposure to radiation.
Dr. Muhammad Furrukh, in the concern of tobacco smoking in the risk of lung cancer, said, "Tobacco smoking remains the most established cause of lung carcinogenesis and other disease processes" and "Over the last 50 years, tobacco refinement and the introduction of filters have brought a change in histology, and now adenocarcinoma has become the most prevalent subtype"
"Over the last decade, smoking also has emerged as a strong prognostic and predictive patient characteristic along with other variables".
Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.
On finding a natural ingredient for the prevention and treatment of lung cancer, researchers looked into the anti-lung cancer effect of anacardic acid (AA), a constituent of the cashew nutshell.
Application of the chemical compound exerted a strong cytotoxic activity against A549 lung adenocarcinoma cells, through the expression of reactive oxidative spices.
AA also activated the proteins associated with cells apoptosis in A549 cells.
Furthermore, in the study of the efficacy of AA against cancer cells, researchers looked into the role of the expression of nuclear factor-kappaB (NF-kappaB) during the cancer inhibition.
Application of AA exerted a strong anti-cancer effect through a series of mechanisms, including induced cancer cells apoptosis by overexpression of proinflammatory cytokines correlated with the inhibition of various gene products associated with cancer cell proliferation and survival.
Moreover, the application of AA also blocked the formation of new blood vessels induced by the tumor.
The finding suggested that AA inhibits the function of NF-κB, a protein complex in controlling the transcription of DNA, cytokine production and cell survival.
Dr. Sung B, after taking into account co and confounders said, " (There is) a novel role for anacardic acid in potentially preventing or treating cancer through modulation of the NF-kappaB signaling pathway".
Taken altogether, Anacardic acid (AA) may be used for the prevention and treatment of lung cancer, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anacardic acid induces mitochondrial-mediated apoptosis in the A549 human lung adenocarcinoma cells by Seong YA, Shin PG, Kim GD. (PubMed)
(2) Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis by Sung B, Pandey MK, Ahn KS, Yi T, Chaturvedi MM, Liu M, Aggarwal BB. (PubMed)
(3) Tobacco Smoking and Lung Cancer. Perception-changing facts by Muhammad Furrukh. (PMC)
Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. Most cases of primary lung cancer start in the cells on the surface of the inner lining of lung tissue.
At the early stage, most patients do not experience any symptoms. However, as cancer continues to advance, it can put pressure on the nearby healthy tissue such as blood vessel and nerve cell, leading to localized symptoms and severe pain.
At the later stage, lung cancells can also travel through blood and fluids circulation to infect other healthy tissue and organ, leading to secondary metastasis.
According to the 2007 statistic, the most common form of primary lung cancers is derived from epithelial cells. In the US, lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women.
The most common form of lung cancer metastasis is brain cancer, according to the statistic, approximately, 40 percent of people with advanced lung cancer will develop brain cancer sometimes during the disease.
The causes of lung cancer are unknown. However, epidemiologically suggested that although there are many risk factors associated with the onset of lung cancers, smoking tobacco, and second-hand smoke are considered the most risk of the diseases.
Other risk factors include radon asbestos, occupational exposure to certain chemicals, outdoor air pollution, personal or family history of lung cancer, personal history of lung disease and long-term exposure to radiation.
Dr. Muhammad Furrukh, in the concern of tobacco smoking in the risk of lung cancer, said, "Tobacco smoking remains the most established cause of lung carcinogenesis and other disease processes" and "Over the last 50 years, tobacco refinement and the introduction of filters have brought a change in histology, and now adenocarcinoma has become the most prevalent subtype"
"Over the last decade, smoking also has emerged as a strong prognostic and predictive patient characteristic along with other variables".
Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.
On finding a natural ingredient for the prevention and treatment of lung cancer, researchers looked into the anti-lung cancer effect of anacardic acid (AA), a constituent of the cashew nutshell.
Application of the chemical compound exerted a strong cytotoxic activity against A549 lung adenocarcinoma cells, through the expression of reactive oxidative spices.
AA also activated the proteins associated with cells apoptosis in A549 cells.
Furthermore, in the study of the efficacy of AA against cancer cells, researchers looked into the role of the expression of nuclear factor-kappaB (NF-kappaB) during the cancer inhibition.
Application of AA exerted a strong anti-cancer effect through a series of mechanisms, including induced cancer cells apoptosis by overexpression of proinflammatory cytokines correlated with the inhibition of various gene products associated with cancer cell proliferation and survival.
Moreover, the application of AA also blocked the formation of new blood vessels induced by the tumor.
The finding suggested that AA inhibits the function of NF-κB, a protein complex in controlling the transcription of DNA, cytokine production and cell survival.
Dr. Sung B, after taking into account co and confounders said, " (There is) a novel role for anacardic acid in potentially preventing or treating cancer through modulation of the NF-kappaB signaling pathway".
Taken altogether, Anacardic acid (AA) may be used for the prevention and treatment of lung cancer, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anacardic acid induces mitochondrial-mediated apoptosis in the A549 human lung adenocarcinoma cells by Seong YA, Shin PG, Kim GD. (PubMed)
(2) Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis by Sung B, Pandey MK, Ahn KS, Yi T, Chaturvedi MM, Liu M, Aggarwal BB. (PubMed)
(3) Tobacco Smoking and Lung Cancer. Perception-changing facts by Muhammad Furrukh. (PMC)
Herbal Ginger, The Potent Anti Alzheimer's disease Inhibitor, Scientists Say
Ginger may be the next pharmaceutical target to extract a single ingredient medicine for the treatment of Alzheimer's disease, some scientists found.
Alzheimer's disease is a common neurodegenerative disease in the elderly characterized by slowly destroys memory and thinking skills and, eventually, the ability to carry out the daily tasks.
According to the Centers for Disease Control and Prevention (CDC), Alzheimer’s disease falls sixth on the list of leading causes of death in the United States.
The average time from diagnosis to death was about four years.
Alzheimer's disease is also increased with an increase in age. In the total of 2,566 people, ages 65 and older under the test of dementia, 559 participants without dementia at the start of the study developed Alzheimer’s disease.
Most common causes of Alzheimer's disease are a combination of genetic, lifestyle, and environmental factors.
However, aging is one most risk factors associated with the onset of the disease in the elderly. Statistics show, the number of people with the disease doubles every 5 years beyond age 65. About one-third of all people age 85 and older may have Alzheimer's disease.
Some researchers suggested that the increase in age and risk of Alzheimer's disease can be attributed to the shrinking of certain parts of the brain, and long-term low-grade inflammation, neuron damage induced by oxidative stress due to overexpression of free radicals.
Dr. Tuppo EE, the lead author of the neuro team at the Western University of Health Sciences said, "There is increasing evidence that free radical-induced oxidative damage may play a role in the pathogenesis of Alzheimer's disease. Free radicals are reactive oxygen compounds that may attack and damage lipids, proteins, and DNA".
And, "The brain is especially sensitive to oxidative damage because of its high content of readily oxidized fatty acids, high use of oxygen, and low levels of antioxidants".
These results clearly suggested that people who follow a healthy diet with high antioxidants such as fruits and vegetables, whole grain and fewer in red meat and processed foods may have a substantially lower risk of Alzheimer's diseases.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding the natural ingredient and whole food with a potential effect on patients with Alzheimer's disease, researchers looked into Ginger (Zingiber officinale), a common dietary adjunct that not contributes to the taste and flavor of foods, but also contain a number of potentially bioactive phytochemicals having valuable medicinal properties.
The differentiation of the binding interactions between active ginger components and various anti-Alzheimer drug targets, researchers suggested the approach could be a promising computational tool to aid optimization of lead compounds obtained from the ginger.
The hydrophobic/hydrophilic interactions of ligands isolated from ginger showed to target acetylcholinesterase, the functioning neurotransmitters, and receptors c-Jun N-terminal kinase which plays an important role in the onset of cognitive impairment.
Additionally, researchers found that all isolated compound is satisfied the Lipinski's rule of five, making them potentially promising drug candidates for the treatment of Alzheimer's disease.
Where Lipinski's rule of five is simply the rule of five (RO5) is a rule to determine if a chemical compound with a certain pharmacological or biological activity has chemical properties.
Moreover, the in-depth investigation of the possible mechanisms of action of these compounds against the AD, scientists compared 4 bioactive compounds isolated from ginger to inhibitors of human acetylcholinesterase (HssAChE), the HssAChE inhibitor and commercial drug in use against the AD, donepezil (DNP).
Unsurprisingly, two among the compounds studied: (E)-1,7-bis(4-hydroxy-3-methoxyphenyl) hept-4-en-3-on and 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3- ethoxyphenyl) heptane-3,5-diycl diacetate, are considered promising new HssAChE inhibitors that could be as effective as DNP.
Based on these results, researchers said, "the binding of the studied compounds in the different binding pockets inside HssAChE and established the preferred interactions to be favored in the design of new and more efficient inhibitors".
Taken altogether, ginger processed abundant bioactive compounds that act as acetylcholinesterase (HssAChE) inhibitor may be used as a functional food for the prevention and treatment of Alzheimer's disease without inducing any side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer's drugs: a computational investigation by Azam F1, Amer AM2, Abulifa AR2, Elzwawi MM2. (PubMed)
(2) A molecular dynamics study of components of the ginger (Zingiber officinale) extract inside human acetylcholinesterase: implications for Alzheimer disease by Cuya T1, Baptista L2, Celmar Costa França T. (PubMed)
(3) Ginger fermented with Schizosaccharomyces pombe alleviates memory impairment via protecting hippocampal neuronal cells in amyloid beta1-42 plaque injected mice by Huh E 1, Lim S , Kim HG , Ha SK , Park HY , Huh Y , Oh MS. (PubMed)
Alzheimer's disease is a common neurodegenerative disease in the elderly characterized by slowly destroys memory and thinking skills and, eventually, the ability to carry out the daily tasks.
According to the Centers for Disease Control and Prevention (CDC), Alzheimer’s disease falls sixth on the list of leading causes of death in the United States.
The average time from diagnosis to death was about four years.
Alzheimer's disease is also increased with an increase in age. In the total of 2,566 people, ages 65 and older under the test of dementia, 559 participants without dementia at the start of the study developed Alzheimer’s disease.
Most common causes of Alzheimer's disease are a combination of genetic, lifestyle, and environmental factors.
However, aging is one most risk factors associated with the onset of the disease in the elderly. Statistics show, the number of people with the disease doubles every 5 years beyond age 65. About one-third of all people age 85 and older may have Alzheimer's disease.
Some researchers suggested that the increase in age and risk of Alzheimer's disease can be attributed to the shrinking of certain parts of the brain, and long-term low-grade inflammation, neuron damage induced by oxidative stress due to overexpression of free radicals.
Dr. Tuppo EE, the lead author of the neuro team at the Western University of Health Sciences said, "There is increasing evidence that free radical-induced oxidative damage may play a role in the pathogenesis of Alzheimer's disease. Free radicals are reactive oxygen compounds that may attack and damage lipids, proteins, and DNA".
And, "The brain is especially sensitive to oxidative damage because of its high content of readily oxidized fatty acids, high use of oxygen, and low levels of antioxidants".
These results clearly suggested that people who follow a healthy diet with high antioxidants such as fruits and vegetables, whole grain and fewer in red meat and processed foods may have a substantially lower risk of Alzheimer's diseases.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding the natural ingredient and whole food with a potential effect on patients with Alzheimer's disease, researchers looked into Ginger (Zingiber officinale), a common dietary adjunct that not contributes to the taste and flavor of foods, but also contain a number of potentially bioactive phytochemicals having valuable medicinal properties.
The differentiation of the binding interactions between active ginger components and various anti-Alzheimer drug targets, researchers suggested the approach could be a promising computational tool to aid optimization of lead compounds obtained from the ginger.
The hydrophobic/hydrophilic interactions of ligands isolated from ginger showed to target acetylcholinesterase, the functioning neurotransmitters, and receptors c-Jun N-terminal kinase which plays an important role in the onset of cognitive impairment.
Additionally, researchers found that all isolated compound is satisfied the Lipinski's rule of five, making them potentially promising drug candidates for the treatment of Alzheimer's disease.
Where Lipinski's rule of five is simply the rule of five (RO5) is a rule to determine if a chemical compound with a certain pharmacological or biological activity has chemical properties.
Moreover, the in-depth investigation of the possible mechanisms of action of these compounds against the AD, scientists compared 4 bioactive compounds isolated from ginger to inhibitors of human acetylcholinesterase (HssAChE), the HssAChE inhibitor and commercial drug in use against the AD, donepezil (DNP).
Unsurprisingly, two among the compounds studied: (E)-1,7-bis(4-hydroxy-3-methoxyphenyl) hept-4-en-3-on and 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3- ethoxyphenyl) heptane-3,5-diycl diacetate, are considered promising new HssAChE inhibitors that could be as effective as DNP.
Based on these results, researchers said, "the binding of the studied compounds in the different binding pockets inside HssAChE and established the preferred interactions to be favored in the design of new and more efficient inhibitors".
Taken altogether, ginger processed abundant bioactive compounds that act as acetylcholinesterase (HssAChE) inhibitor may be used as a functional food for the prevention and treatment of Alzheimer's disease without inducing any side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer's drugs: a computational investigation by Azam F1, Amer AM2, Abulifa AR2, Elzwawi MM2. (PubMed)
(2) A molecular dynamics study of components of the ginger (Zingiber officinale) extract inside human acetylcholinesterase: implications for Alzheimer disease by Cuya T1, Baptista L2, Celmar Costa França T. (PubMed)
(3) Ginger fermented with Schizosaccharomyces pombe alleviates memory impairment via protecting hippocampal neuronal cells in amyloid beta1-42 plaque injected mice by Huh E 1, Lim S , Kim HG , Ha SK , Park HY , Huh Y , Oh MS. (PubMed)
Tuesday, April 2, 2019
Honey, The Potential Food for Obesity Control
Compared to an ideal weight, that reduces the risk of cardiovascular disease, body weight greater than 20 percent is considered obese.
Obesity is a medical condition caused by excess body fat has accumulated over time, while overweight is a condition of excess body weight relative to the height.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.
Epidemiological studies in the investigation of the complication of obesity found that cardiovascular problems such as high blood pressure, heart disease, accelerated atherosclerosis, and stroke... and chronic lower back pain are most common disease complications associated with obesity.
According to data from the National Health and Nutrition Examination Survey (NHANES), 2013–2014, more than 1 in 3 and 13 adults in the US were considered to have obesity and extreme obesity, respectively.
Although there are many risk factors involved in the onset of the disease, some researchers suggested an unhealthy lifestyle is one of the major causes of obesity in the Western world.
Dr. Robert F. Kushner, in the examination of the unhealthy lifestyle risk of obesity of the 53‐item lifestyle pattern questionnaire posted on a commercial weight loss program Web site collected from 2004 through 2008, wrote, "unhealthy lifestyle patterns in diet, exercise, and coping were highly prevalent among this population".
The results findings clearly suggested a strong correlation between diet, exercise, and obesity.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the urgency to find a natural remedy for the treatment of widespread obesity in the Western world, researchers evaluated the potential of honey consumption in controlling obesity.
The study compared the two local Malaysian honey types: Gelam and Acacia honey activities in reducing excess weight gain and other parameters related to obesity.
Male Sprague-Dawley rats selected to the study were induced obese by a high-fat diet (HFD) prior to introduction with/without honey or orlistat for four weeks.
Rats fed with Gelam honey showed significant reductions in excess weight gain and adiposity index compared to HFD rats.
Furthermore, parameters related to obesity such as levels of plasma glucose, triglycerides, and cholesterol, plasma leptin and resistin, liver enzymes, renal function, and relative organ weight in Gelam and Acacia honey treated groups were reduced significantly, compared to obese rats.
Compared to the treatment of orlistat, Gelam and Acacia honey showed similar results without inducing hepatotoxicity effects.
Hepatotoxicity is a known side effect of orlistat.
Where Orlistat is a drug used for the treatment of obesity, sold over-the-counter as Alli by GlaxoSmithKline in the United Kingdom and the United States.
Dr. Samat S, the lead scientists wrote in the final report, "consumption of honey can be used to control obesity by regulating lipid metabolism and appears to be more effective than orlistat".
Taken altogether, hiney, particularly Gelam and Acacia honey may be considered anti-obesity functional remedies with no side effects, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Four-Week Consumption of Malaysian Honey Reduces Excess Weight Gain and Improves Obesity-Related Parameters in High Fat Diet Induced Obese Rats by Samat S1, Kanyan Enchang F1, Nor Hussein F2, Wan Ismail WI. (PubMed)
Obesity is a medical condition caused by excess body fat has accumulated over time, while overweight is a condition of excess body weight relative to the height.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.
Epidemiological studies in the investigation of the complication of obesity found that cardiovascular problems such as high blood pressure, heart disease, accelerated atherosclerosis, and stroke... and chronic lower back pain are most common disease complications associated with obesity.
According to data from the National Health and Nutrition Examination Survey (NHANES), 2013–2014, more than 1 in 3 and 13 adults in the US were considered to have obesity and extreme obesity, respectively.
Although there are many risk factors involved in the onset of the disease, some researchers suggested an unhealthy lifestyle is one of the major causes of obesity in the Western world.
Dr. Robert F. Kushner, in the examination of the unhealthy lifestyle risk of obesity of the 53‐item lifestyle pattern questionnaire posted on a commercial weight loss program Web site collected from 2004 through 2008, wrote, "unhealthy lifestyle patterns in diet, exercise, and coping were highly prevalent among this population".
The results findings clearly suggested a strong correlation between diet, exercise, and obesity.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the urgency to find a natural remedy for the treatment of widespread obesity in the Western world, researchers evaluated the potential of honey consumption in controlling obesity.
The study compared the two local Malaysian honey types: Gelam and Acacia honey activities in reducing excess weight gain and other parameters related to obesity.
Male Sprague-Dawley rats selected to the study were induced obese by a high-fat diet (HFD) prior to introduction with/without honey or orlistat for four weeks.
Rats fed with Gelam honey showed significant reductions in excess weight gain and adiposity index compared to HFD rats.
Furthermore, parameters related to obesity such as levels of plasma glucose, triglycerides, and cholesterol, plasma leptin and resistin, liver enzymes, renal function, and relative organ weight in Gelam and Acacia honey treated groups were reduced significantly, compared to obese rats.
Compared to the treatment of orlistat, Gelam and Acacia honey showed similar results without inducing hepatotoxicity effects.
Hepatotoxicity is a known side effect of orlistat.
Where Orlistat is a drug used for the treatment of obesity, sold over-the-counter as Alli by GlaxoSmithKline in the United Kingdom and the United States.
Dr. Samat S, the lead scientists wrote in the final report, "consumption of honey can be used to control obesity by regulating lipid metabolism and appears to be more effective than orlistat".
Taken altogether, hiney, particularly Gelam and Acacia honey may be considered anti-obesity functional remedies with no side effects, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Four-Week Consumption of Malaysian Honey Reduces Excess Weight Gain and Improves Obesity-Related Parameters in High Fat Diet Induced Obese Rats by Samat S1, Kanyan Enchang F1, Nor Hussein F2, Wan Ismail WI. (PubMed)
Herbal Ginger, the Natural Anti Male Infertility Functional Remedy
Fertility is a natural capacity for producing offspring.
According to traditional Chinese medicine, all women with no reproductive structure problems in the childbearing year are once fertile. However, due to many reasons such as the use of contraceptive, and workplace stress, some women and men have developed unexplained causes of infertility.
Unexplained causes of infertility is a condition of not getting pregnant in a couple without knowing causes.
Infertility is a condition that a female of a couple cannot get pregnant after 12 months of unprotected sexual intercourse, including those cannot carry the pregnancy to term.
According to the statistics provided by the Centers for Disease Control and Prevention (CDC), approximately 10 percent of women (6.1 million) in the United States ages 15-44 have difficulty getting pregnant or staying pregnant compared to 5-6% of males are infertile,
In males, although the sperm in the male reproductive organ does not change much, the quality and quantity of sperm may be reduced by low levels of testosterone due to aging.
These explained why a couple in their late 20's is easier to conceive than a couple with a wife in her 20's and a husband at the age of 40 and more.
According to the study of the European Society of Human Reproduction and Embryology, the rate of miscarriage also increases substantially when the father was over the age of 35.
1. Nearly 17 percent if the father was over 34 years old.
2. Around 20 percent if the father was between the ages of 35 and 39.
3. Over 32 percent if the father was older than 44.
In fact, the odds of male fertility rate decreases at an alarming rate of 11% every year and the chance for his partner to conceive declines even further over the past few decades.
The results strongly suggested that if you follow a healthy diet with nutrients diet by focusing on calories, macronutrients, you may delay the process of biological aging, including the reproductive organs.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural ingredient for the treatment of male infertility examined the effects of ginger (Zingiber officinale) on sperm DNA fragmentation (SDF) in infertile men.
This randomized double-blind, placebo-controlled trial with a 1:1 allocation included 100 selected infertility candidates who were admitted to Royan Institute for Reproductive Biomedicine, Tehran, Iran.
Patients were randomly assigned to receive either ginger given a 3-month oral treatment (members received capsules containing 250 mg of ginger powder twice a day in ginger or placebo.
By analyzing the sperm concentration, motility, and SDF from the standardized semen samples before and after treatment, according to the World Health Organization, researchers found that
according to the multivariate analysis, patients receiving ginger (17.77, 95%CI: 6.16-29.39) was found to have a lower average positive percentage of SDF in compared with placebo, after three months of treatment without affecting the semen parameters.
In other words, ginger improves male fertility by decreasing SDF in infertile men.
Where SDF assay is a better diagnostic potential in evaluating the male infertilities, particularly in those with unexplained cause of infertility.
Researchers in the differentiation of the role of sperm DNA fragmentation in male factor infertility
wrote, "The significant role of SDF in male factor infertility is supported by current evidence. The beneficial role of SDF testing in the selection of varicocelectomy candidates, evaluation of patients with unexplained infertility and recurrent pregnancy loss, selection of the most appropriate assisted reproductive technique with the highest success rate for infertile couples, and assessment of infertile men with modifiable lifestyle factors or gonadotoxin exposure has been recently proposed".
Taken altogether, ginger may be considered a functional remedy for the improvement of male fertility, pending to the confirmation of larger sample sized and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial by Jalil Hosseini, M.D.,1,2 Azar Mardi Mamaghani, M.Sc.,2 Hani Hosseinifar, Ph.D.,2Mohammad Ali Sadighi Gilani, M.D.,2,3 Farid Dadkhah, M.D.,2 and Mahdi Sepidarkish, Ph.D. (PMC)
(2) Role of sperm DNA fragmentation in male factor infertility: A systematic review by Chak-Lam Choa,1 and Ashok Agarwalb. (PMC)
According to traditional Chinese medicine, all women with no reproductive structure problems in the childbearing year are once fertile. However, due to many reasons such as the use of contraceptive, and workplace stress, some women and men have developed unexplained causes of infertility.
Unexplained causes of infertility is a condition of not getting pregnant in a couple without knowing causes.
Infertility is a condition that a female of a couple cannot get pregnant after 12 months of unprotected sexual intercourse, including those cannot carry the pregnancy to term.
According to the statistics provided by the Centers for Disease Control and Prevention (CDC), approximately 10 percent of women (6.1 million) in the United States ages 15-44 have difficulty getting pregnant or staying pregnant compared to 5-6% of males are infertile,
In males, although the sperm in the male reproductive organ does not change much, the quality and quantity of sperm may be reduced by low levels of testosterone due to aging.
These explained why a couple in their late 20's is easier to conceive than a couple with a wife in her 20's and a husband at the age of 40 and more.
According to the study of the European Society of Human Reproduction and Embryology, the rate of miscarriage also increases substantially when the father was over the age of 35.
1. Nearly 17 percent if the father was over 34 years old.
2. Around 20 percent if the father was between the ages of 35 and 39.
3. Over 32 percent if the father was older than 44.
In fact, the odds of male fertility rate decreases at an alarming rate of 11% every year and the chance for his partner to conceive declines even further over the past few decades.
The results strongly suggested that if you follow a healthy diet with nutrients diet by focusing on calories, macronutrients, you may delay the process of biological aging, including the reproductive organs.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural ingredient for the treatment of male infertility examined the effects of ginger (Zingiber officinale) on sperm DNA fragmentation (SDF) in infertile men.
This randomized double-blind, placebo-controlled trial with a 1:1 allocation included 100 selected infertility candidates who were admitted to Royan Institute for Reproductive Biomedicine, Tehran, Iran.
Patients were randomly assigned to receive either ginger given a 3-month oral treatment (members received capsules containing 250 mg of ginger powder twice a day in ginger or placebo.
By analyzing the sperm concentration, motility, and SDF from the standardized semen samples before and after treatment, according to the World Health Organization, researchers found that
according to the multivariate analysis, patients receiving ginger (17.77, 95%CI: 6.16-29.39) was found to have a lower average positive percentage of SDF in compared with placebo, after three months of treatment without affecting the semen parameters.
In other words, ginger improves male fertility by decreasing SDF in infertile men.
Where SDF assay is a better diagnostic potential in evaluating the male infertilities, particularly in those with unexplained cause of infertility.
Researchers in the differentiation of the role of sperm DNA fragmentation in male factor infertility
wrote, "The significant role of SDF in male factor infertility is supported by current evidence. The beneficial role of SDF testing in the selection of varicocelectomy candidates, evaluation of patients with unexplained infertility and recurrent pregnancy loss, selection of the most appropriate assisted reproductive technique with the highest success rate for infertile couples, and assessment of infertile men with modifiable lifestyle factors or gonadotoxin exposure has been recently proposed".
Taken altogether, ginger may be considered a functional remedy for the improvement of male fertility, pending to the confirmation of larger sample sized and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial by Jalil Hosseini, M.D.,1,2 Azar Mardi Mamaghani, M.Sc.,2 Hani Hosseinifar, Ph.D.,2Mohammad Ali Sadighi Gilani, M.D.,2,3 Farid Dadkhah, M.D.,2 and Mahdi Sepidarkish, Ph.D. (PMC)
(2) Role of sperm DNA fragmentation in male factor infertility: A systematic review by Chak-Lam Choa,1 and Ashok Agarwalb. (PMC)
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