Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
1. Ginger, The Pungent Spice Which Processes Anti Colon Cancer Potential
2. Ginger Processes A Potency for the Prevention and Treatment of Osteoarthritis
3. Ginger, The Alternative Pain Killer for Muscle Pain and Soreness With No Side Effect
4. Ginger, The Spice Which Protects Our Body Against Inflammatory Diseases
5. Ginger, the Heart and Blood Vessels Friendly Functional Spice
6. Ginger Processes Anti Cancer Potential, Scientists Suggest
7. Ginger, the Kitchen Spice Which Suppresses the Onset and Progression of Rheumatoid Arthritis
8. Ginger, the Potential Remedy for the Prevention and Treatment of Atherosclerosis with No Side Effects
9. Ginger, The Best Functional Food For Symptoms of Nausea and Vomiting
10. Ginger In the Prevention and Treatment of Nonalcoholic Hepatic Steatosis (Fatty Liver)
11. Ginger, The Anti Gastrointestinal Disorder Functional Pungent Spice
12. Ginger, the Pungent Spice Protects Men Against Testosterone Deficiency with No Side Effects, According to Studies
13. Ginger, The Best Remedy for the Prevention and Treatment of Dysmenorrhea
14. Ginger, the Potent anti-Metabolic Syndrome Pungent Spice, Scientists Say
15. Ginger, Relieves Pain and Reduced Disability of Patients with Osteoarthritis
16. Ginger, The Best to Normal Your Blood Cholesterol With No Side Effects
17. Ginger, the Potent Free radical Scavenging activities
18. Ginger, the Pungent Spice Which inhibits the Onset and Progression of arthritis
19. Ginger, The Potent Anti Obesity Functional Food
20. Ginger, The Potential Anti Breast Cancer Functional Remedy, Studies Found
21. Ginger, the Natural Anti Oxidative Stress Functional Food
22. Ginger, The Natural Alternative Antibiotic for The Treatment of Parasite Infection
23. Ginger, The Potential Anti Type 2 Diabetes Pungent Spice, Scientists Say
24. Ginger, the Potential Anti-Airway Hyperresponsiveness in Asthmatic Patients
25. Ginger Kills Retinoblastoma Cancer Cells
26. Ginger, the Best Neuroprotective Functional Remedy
27. Ginger, the Best Anti Lung Cancer Remedy
28. Ginger, The Potent Anti Alzheimer's disease Inhibitor, Scientists Say
19. Ginger, The Natural Anti Oral Cancer Herbal Remedy with No Side Effects
20. Ginger, the Potent and Natural Therapy for Rheumatic Diseases
21. Ginger, The Best for the Treatment of Diabetes and Diabetes Complications With No Side Effect
22. Ginger, the Natural Antibiotics Alternative Functional Spice
23. Ginger and Shell Ginger in the Promotion of Healthy Longevity, According to Studies
24. Ginger, the Remedy Effect On Fat and Glucose Metabolism Under Psychological and Oxidative Stress
25. Ginger, The Potential Anti Ulcerative Colitis Functional Spice
26. Ginger, the Natural Anti Prostate Cancer Remedy with No Side Effects, Scientists Reveal
27. Ginger, the Anti Cervical Cancer Functional Remedy, According to Studies
28. Ginger Combined with Other Herbal Medicines for The Treatment of Erectile Dysfunction
29. Ginger Reverses the Cognitive Impairment Caused by Oxidative Stress
30. Ginger, the Best for the Prevention and Treatment of Metabolic Dysfunction with No Side Effects
31. Ginger, the Natural Alternative for Treatment of Bacterial and Fungal Infection
32. Ginger, the Natural Chemotherapy
33. Ginger, the Best Natural Remedy with Anti Colon Cancer Potential
34. Ginger, the Anti Chronic Mild Stress and Arteriosclerosis Natural Remedy
35. Ginger, the Natural Antibiofilm Remedy with No Side Effects
36. Ginger, the Potential Anti-Septic Functional Remedy, Scientists Show
37. Ginger, the Herbal Remedy Which Promotes Weight Loss
38. Ginger, A Natural Treatment for Parkinson disease (PD) with No Side Effects
39. Ginger, The Best Gastroprotective Functional Pungent Spice
40. Ginger, the Magic Pungent Spice for the Treatment of Muscle Pain
41. Ginger, the Potential Anti-Aging Remedy with No Side Effects, According to Scientists
42. Ginger Protects Our Eyes Against Cataract
43. Herbal Ginger, the Natural Treatment of Gastric/Stomach Ulcers
44. Herbal Ginger, the Potential Anti Hyperlipidemia Functional Remedy, Researchers Find
45. Herbal Ginger Detoxes Liver Acute Toxicity and Improves Liver Functioning In ViVo, According to Studies
46. How to Relieve Dysmenorrhea Naturally and Effectively
47. Herbal Ginger, The Potential Anti-Male infertility Functional Remedy, Researchers Find
48. Ginger Inhibits the Production of Advanced Glycation End (AGEs) Products Against the Onset of Chronic Diseases, According to Studies
49. Herbal Ginger, the Natural Anti Male Infertility Functional Remedy
50. Herbal Ginger, the Anti-Virulence Functional Remedy
51. Ginger' 6-Gingerol Processes Anti-Female Infertility Activity With No Side Effects, Scientists Say
52. Herbal Ginger, the Potential Remedy for the Prevention and Treatment of Head and Neck Cancer, According to Studies
53. Herbal Ginger, the Potential and Natural Antihypothermia Functional Food, According to Scientists
54. Herbal Ginger, the Best Remedy Which Protects Your Kidney Against Heavy Metal Toxicity, According to Studies
55. Functional Food Ginger, the Potential Anti-Cancer Herbal Remedy with No Side Effects, According to Scientists
56. Herbal Ginger Protects the Joints Against Osteoarthritis In Human Trials
To Be Continued
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Saturday, May 4, 2019
Friday, May 3, 2019
Phytochemical 3,3'-Diindolylmethane, the Potential Anti Colorectal Cancer Phytochemicals With No Side Effects, Researchers Find
3,3'-Diindolylmethane or DIM may be used as a bioactive compound for the treatment of colorectal cancer with no side effects, according to studies.
Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA.
According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.
The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. The cancer also causes of death of over 50, 000 people, representing 8.3% of total cancer death.
Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, the increased in age, family and personal history, genetic preposition are some of the prevalent risks of the disease.
Some researchers suggested that unhealthy diet such as the promotion of the Western diet over the past few decades may be one of the major causes of colorectal cancer.
Dr. Alan Moss, the lead scientist in the evaluation of the association of between diet and colorectal cancer risk, wrote, "Studies that examined dietary factors and various cancers showed that one of the strongest associations is between CRC and meat consumption"
And "Recently, global publicity was generated by the World Health Organization International Agency for Research on Cancer consensus statement regarding the increased risk of CRC with consumption of processed or red meat.4 The 2015 statement notes that processed meat is carcinogenic to humans and lists processed meat as a group 1 substance. Processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage".
The results clearly suggested that by changing your diet pattern from the Western diet to a traditional diet with high fruits and vegetables, your risk colorectal can be reduced substantially.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers in the concern of the slow growth of colorectal cancer and the prognosis in colorectal cancer patients examined the effects of 3,3'-Diindolylmethane (DIM) on cyclin D1, which was aberrantly overexpressed in colorectal cancer cells and tumors.
Where cyclin D1 is a protein needed for cellular proliferation in the G1 phase of the cell cycle.
Injection of DIM inhibited the cyclin D1 expression in colorectal cancer cells (CRC), without affecting the PPARγ expression and protease activity in regulating the process of cell differentiation.
Moreover, DIM inhibition of the cell cycle in the G1 phase of colorectal cancer cells (CRC) without alternating the cyclin D1 mRNA expression. The results suggested DIM modulated cyclin D1 expression at the translational level through some unknown mechanisms.
Dr. Zhang X and colleagues wrote in the final report, "the present study demonstrates that DIM downregulates cyclin D1 through triggering ER stress in human colorectal cancer cells".
In other words, DIM-induced cell cycle arrest of the colorectal cancer cells by modulating the G1 phase of the cell cycle.
Additionally, in order to reveal more information about the DIM anti-colorectal cancer activity, researchers elucidated the molecular mechanism of ATF3 induction by DIM in human CRC cells.
The DIM treatment induced apoptosis and induced ATF3 gene expression at protein and messenger RNA levels, involving the DNA repair of the damaged cells.
However, in colorectal cancer cells, deletion and point mutation of the ATF binding site (-23 to -16) abolished ATF3 promoter activation by DIM, leading to overexpression of ATF4 associated with the promotion metabolic homeostasis and cancer cell survival
In other words, DIM stimulates ATF3 expression in inducing apoptosis in human colorectal cells through inhibiting the ATF4-mediated pathway.
Taken altogether, 3,3'-Diindolylmethane derived from I3C may be considered a supplement for the prevention and combined with primary therapy for the treatment of colorectal cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells by Zhang X1, Sukamporn P2, Zhang S3, Min KW4, Baek SJ. (PubMed)
(2) 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells by Lee SH1, Min KW, Zhang X, Baek SJ. (PubMed)
(3) The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations
Alan Moss, and Kumanan Nalankilli. (Gastroenterology)
Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA.
According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.
The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. The cancer also causes of death of over 50, 000 people, representing 8.3% of total cancer death.
Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, the increased in age, family and personal history, genetic preposition are some of the prevalent risks of the disease.
Some researchers suggested that unhealthy diet such as the promotion of the Western diet over the past few decades may be one of the major causes of colorectal cancer.
Dr. Alan Moss, the lead scientist in the evaluation of the association of between diet and colorectal cancer risk, wrote, "Studies that examined dietary factors and various cancers showed that one of the strongest associations is between CRC and meat consumption"
And "Recently, global publicity was generated by the World Health Organization International Agency for Research on Cancer consensus statement regarding the increased risk of CRC with consumption of processed or red meat.4 The 2015 statement notes that processed meat is carcinogenic to humans and lists processed meat as a group 1 substance. Processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage".
The results clearly suggested that by changing your diet pattern from the Western diet to a traditional diet with high fruits and vegetables, your risk colorectal can be reduced substantially.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers in the concern of the slow growth of colorectal cancer and the prognosis in colorectal cancer patients examined the effects of 3,3'-Diindolylmethane (DIM) on cyclin D1, which was aberrantly overexpressed in colorectal cancer cells and tumors.
Where cyclin D1 is a protein needed for cellular proliferation in the G1 phase of the cell cycle.
Injection of DIM inhibited the cyclin D1 expression in colorectal cancer cells (CRC), without affecting the PPARγ expression and protease activity in regulating the process of cell differentiation.
Moreover, DIM inhibition of the cell cycle in the G1 phase of colorectal cancer cells (CRC) without alternating the cyclin D1 mRNA expression. The results suggested DIM modulated cyclin D1 expression at the translational level through some unknown mechanisms.
Dr. Zhang X and colleagues wrote in the final report, "the present study demonstrates that DIM downregulates cyclin D1 through triggering ER stress in human colorectal cancer cells".
In other words, DIM-induced cell cycle arrest of the colorectal cancer cells by modulating the G1 phase of the cell cycle.
Additionally, in order to reveal more information about the DIM anti-colorectal cancer activity, researchers elucidated the molecular mechanism of ATF3 induction by DIM in human CRC cells.
The DIM treatment induced apoptosis and induced ATF3 gene expression at protein and messenger RNA levels, involving the DNA repair of the damaged cells.
However, in colorectal cancer cells, deletion and point mutation of the ATF binding site (-23 to -16) abolished ATF3 promoter activation by DIM, leading to overexpression of ATF4 associated with the promotion metabolic homeostasis and cancer cell survival
In other words, DIM stimulates ATF3 expression in inducing apoptosis in human colorectal cells through inhibiting the ATF4-mediated pathway.
Taken altogether, 3,3'-Diindolylmethane derived from I3C may be considered a supplement for the prevention and combined with primary therapy for the treatment of colorectal cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells by Zhang X1, Sukamporn P2, Zhang S3, Min KW4, Baek SJ. (PubMed)
(2) 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells by Lee SH1, Min KW, Zhang X, Baek SJ. (PubMed)
(3) The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations
Alan Moss, and Kumanan Nalankilli. (Gastroenterology)
Turmeric, the Potential Spice that Detoxes Your Lung Against Toxicity
Lung toxicity or pulmonary toxicity refers to the toxicity induced by the side effects of the lung in patients under chemotherapy or radiotherapy.
Most common drugs associated with lung toxicity used for the treatment of cancer include Arsenic trioxide (Trisenox®) Bleomycin (Blenoxane®)1 Idarubicin (Idamycin®).
However, lung toxicity is also caused by inhaling chemical compounds, the most famous (infamous) example is pulmonary toxicity due to asbestos. air pollution and airborne particulate matter produced by car traffic, overland traffic (trucks), industrial production facilities, and cigarette smoking.
Symptoms of lung damage or toxicity are a shortage of breath, breathlessness during exercise, fatigue dry cough Shortness of breath, particularly the symptoms that worsen when lying on your back breath.
Acute pulmonary toxicity, the damage to the lungs that resolves with a short period of time by addressing the cause.
Conventionally, most common treatments of lung toxicity are the use of
* Corticosteroids to decrease inflammation and relieve the cough and pain
*Narcotics to reduce pain medications and promote breathing center
* Oxygen therapy to increase oxygen in the blood and prevent shortness of breath.
In severe cases, patients may be sent to the hospital for Pulmonary (lung) rehabilitation.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of lung toxicity scientists evaluated the protective effects of curcumin on lipid peroxidation and antioxidants status in bronchoalveolar lavage fluid (BALF) and bronchoalveolar lavage (BAL) of a nicotine-treated animal model.
Wistar rats selected to the study were induced lung toxicity by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (5 days a week, for 22 weeks) and following by administration of curcumin (80 mg/kg body weight) given simultaneously by intragastric intubation for 22 weeks.
Before injecting of curcumin, injection of nicotine rats showed the increased biochemical marker enzymes, lipid peroxides in BALF and BAL of accompanied by a significant decrease in the levels of antioxidant in the lung.
Following the treatment of curcumin, infected rats showed a significantly lowered the biochemical marker enzymes, lipid peroxidation and enhanced the antioxidant status.
Based on the results, researchers said, "The results of the present study suggest that curcumin exert its protective effect against nicotine-induced lung toxicity by modulating the biochemical marker enzymes, lipid peroxidation and augmenting antioxidant defense system".
In order to reveal more information about turmeric detoxed activity, researchers examined the protective role of curcumin and a synthetic analog of curcumin (BDMC-A) on nicotine-induced oxidative stress.
Male albino rats of Wistar strain selected to the study induced lung toxicity by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (five days a week, for 22 weeks) and followed by the treatment of curcuminoids given simultaneously by intragastric intubation for 22 weeks.
Nicotine-treated groups before injection of curcumin showed increased oxidative stress, as evidenced by lipid peroxidation indices.
Injection of curcumin and BDMC-A not only restored the antioxidant status which was decreased in the nicotine-treated group.
Based on the findings, researchers said, "The present study suggests that BDMC-A exerts its protective effect by modulating the extent of lipid peroxidation and augmenting the antioxidant defense system".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of lung toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in Wistar rats by Kalpana C1, Menon VP. (PubMed)
(2) Comparative effects of curcumin and its synthetic analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity by Kalpana C1, Sudheer AR, Rajasekharan KN, Menon VP. (PubMed)
Most common drugs associated with lung toxicity used for the treatment of cancer include Arsenic trioxide (Trisenox®) Bleomycin (Blenoxane®)1 Idarubicin (Idamycin®).
However, lung toxicity is also caused by inhaling chemical compounds, the most famous (infamous) example is pulmonary toxicity due to asbestos. air pollution and airborne particulate matter produced by car traffic, overland traffic (trucks), industrial production facilities, and cigarette smoking.
Symptoms of lung damage or toxicity are a shortage of breath, breathlessness during exercise, fatigue dry cough Shortness of breath, particularly the symptoms that worsen when lying on your back breath.
Acute pulmonary toxicity, the damage to the lungs that resolves with a short period of time by addressing the cause.
Conventionally, most common treatments of lung toxicity are the use of
* Corticosteroids to decrease inflammation and relieve the cough and pain
*Narcotics to reduce pain medications and promote breathing center
* Oxygen therapy to increase oxygen in the blood and prevent shortness of breath.
In severe cases, patients may be sent to the hospital for Pulmonary (lung) rehabilitation.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of lung toxicity scientists evaluated the protective effects of curcumin on lipid peroxidation and antioxidants status in bronchoalveolar lavage fluid (BALF) and bronchoalveolar lavage (BAL) of a nicotine-treated animal model.
Wistar rats selected to the study were induced lung toxicity by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (5 days a week, for 22 weeks) and following by administration of curcumin (80 mg/kg body weight) given simultaneously by intragastric intubation for 22 weeks.
Before injecting of curcumin, injection of nicotine rats showed the increased biochemical marker enzymes, lipid peroxides in BALF and BAL of accompanied by a significant decrease in the levels of antioxidant in the lung.
Following the treatment of curcumin, infected rats showed a significantly lowered the biochemical marker enzymes, lipid peroxidation and enhanced the antioxidant status.
Based on the results, researchers said, "The results of the present study suggest that curcumin exert its protective effect against nicotine-induced lung toxicity by modulating the biochemical marker enzymes, lipid peroxidation and augmenting antioxidant defense system".
In order to reveal more information about turmeric detoxed activity, researchers examined the protective role of curcumin and a synthetic analog of curcumin (BDMC-A) on nicotine-induced oxidative stress.
Male albino rats of Wistar strain selected to the study induced lung toxicity by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (five days a week, for 22 weeks) and followed by the treatment of curcuminoids given simultaneously by intragastric intubation for 22 weeks.
Nicotine-treated groups before injection of curcumin showed increased oxidative stress, as evidenced by lipid peroxidation indices.
Injection of curcumin and BDMC-A not only restored the antioxidant status which was decreased in the nicotine-treated group.
Based on the findings, researchers said, "The present study suggests that BDMC-A exerts its protective effect by modulating the extent of lipid peroxidation and augmenting the antioxidant defense system".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of lung toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in Wistar rats by Kalpana C1, Menon VP. (PubMed)
(2) Comparative effects of curcumin and its synthetic analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity by Kalpana C1, Sudheer AR, Rajasekharan KN, Menon VP. (PubMed)
Thursday, May 2, 2019
Plant-Based Bioactive Compound 3,3'-Diindolylmethane Kills Lung Cancer Cells in Vivo
Lung cancer is a medical and chronic condition associated with the alternation of the cells in the lung tissue.
Most cases of lung cancer start in the cell on the surface of the inner lining of lung tissue before striking into deeper layers.
At the early stage, due to the small size of the tumor, most patients are asymptomatic. However, at the advanced stage, besides the common symptoms shared with other types of cancer, the patients may also experience symptoms of difficult breathing, persistent cough and hoarseness, and chest pain.
Some patients may also vomit blood caused by the oversize tumor suppressing on the nearby blood vessels.
Lung cancer is diagnosed mostly in the elderly, particularly in people over 65 years of age.
The mortality rate of lung cancer is higher than the colon, breast, and prostate cancers combined.
According to the statistics, In Canada, the 5-year net survival for lung cancer is 17%.
In other words, on average, only 17% of people diagnosed with lung cancer will survive for at least 5 years after their diagnosis.
However, lung cancer at the early localized stage has 5 years of the survival rate of 60%.
Although there are many risk factors associated with the onset of lung cancer, smoking is considered epidemiologically a major cause of the disease onset.
Dr. Ozlü T, the lead scientist in the examination of smoking and lung cancer risk, "The association between cigarettes and lung cancer has been proven by large cohort studies. Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking. The risk of lung cancer development is 20-40 times higher in lifelong smokers compared to non-smokers".
And, "After smoking cessation, the cumulative death risk from lung cancer decreases. Patients who continue smoking experience greater difficulties during cancer treatment. Stopping smoking may prolong survival in cancer patients, and also decreases the risk of recurrent pulmonary carcinoma".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers in the concern about the risk of inflammatory conditions of the lung such as chronic obstructive pulmonary disease (COPD) that contributes to the onset of lung cancer risk, particularly lung squamous cell carcinoma (LSCC) examined the chemopreventive effects of BioResponse diindolylmethane (DIM).
The study included a mouse model of inflammation-driven LSCC induced by N-nitroso-trischloroethylurea (NTCU) and enhanced by lipopolysaccharide (LPS), a potent pro-inflammatory agent contained in tobacco and tobacco smoke.
Before treatment of DIM, mice treated with the combination of NTCU and LPS had a 9-fold increase in the number of bronchioles with LSC.
Compared to mice treated with LPS alone, mice treated with NTCU plus LPS showed significantly increased expression of the pro-inflammatory cytokines, accompanied by the increased expression of proteins associated with the production of pro-inflammation and cancer cells initiation.
Pretreatment of DIM at a concentration of 0 μmol/g diet or 2,460 ppm) to mice treated with NTCU plus LPS reduced the incidence of LSCC by 2-fold and suppressed activation/expression of proinflammatory and procarcinogenic proteins without affecting the expression of cytokines and p53, a tumor suppressive gene.
In other words, DIM blocked the development of LSCC through cytotoxicity and gene associated with tumor suppression.
In order to reveal more information about DIM anti-lung cancer property, researchers looked into the anticancer efficacy of 1,1-bis (3'-indolyl)-1-(p-biphenyl) methane (DIM-C-pPhC₆H₅) inhalation delivery alone and in combination with i.v. docetaxel in a murine model.
According to assays, the lung weight reduction in mice treated with the drug combination was 64% compared with 40% and 47% in mice treated with DIM-C-pPhC₆H₅ aerosol and docetaxel alone, respectively.
The combination treatment inhibited the lung cancer by decreased expression of proteins associated with the pro-inflammatory cytokines, cancer cells survival, and proliferation through stimulating the production of the new blood vessels.
Furthermore, the combination also increased expression of genes involved autophagy in the tumor formation, compared to the tumor cell counts from single-agent treatment and control groups.
Dr. Ichite N, the lead scientist said, "These results suggest that DIM-C-pPhC₆H₅ aerosol enhanced the anticancer activity of docetaxel in a lung cancer model by activating multiple signaling pathways".
Taken altogether, 3,3'-Diindolylmethane may be considered a supplement for the prevention and combined with primary medicine for the treatment of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary diindolylmethane suppresses inflammation-driven lung squamous cell carcinoma in mice by Song JM1, Qian X1, Teferi F1, Pan J2, Wang Y2, Kassie F. (PubMed)
(2) Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer by Ichite N1, Chougule M, Patel AR, Jackson T, Safe S, Singh M. (PubMed)
(3) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)
Most cases of lung cancer start in the cell on the surface of the inner lining of lung tissue before striking into deeper layers.
At the early stage, due to the small size of the tumor, most patients are asymptomatic. However, at the advanced stage, besides the common symptoms shared with other types of cancer, the patients may also experience symptoms of difficult breathing, persistent cough and hoarseness, and chest pain.
Some patients may also vomit blood caused by the oversize tumor suppressing on the nearby blood vessels.
Lung cancer is diagnosed mostly in the elderly, particularly in people over 65 years of age.
The mortality rate of lung cancer is higher than the colon, breast, and prostate cancers combined.
According to the statistics, In Canada, the 5-year net survival for lung cancer is 17%.
In other words, on average, only 17% of people diagnosed with lung cancer will survive for at least 5 years after their diagnosis.
However, lung cancer at the early localized stage has 5 years of the survival rate of 60%.
Although there are many risk factors associated with the onset of lung cancer, smoking is considered epidemiologically a major cause of the disease onset.
Dr. Ozlü T, the lead scientist in the examination of smoking and lung cancer risk, "The association between cigarettes and lung cancer has been proven by large cohort studies. Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking. The risk of lung cancer development is 20-40 times higher in lifelong smokers compared to non-smokers".
And, "After smoking cessation, the cumulative death risk from lung cancer decreases. Patients who continue smoking experience greater difficulties during cancer treatment. Stopping smoking may prolong survival in cancer patients, and also decreases the risk of recurrent pulmonary carcinoma".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers in the concern about the risk of inflammatory conditions of the lung such as chronic obstructive pulmonary disease (COPD) that contributes to the onset of lung cancer risk, particularly lung squamous cell carcinoma (LSCC) examined the chemopreventive effects of BioResponse diindolylmethane (DIM).
The study included a mouse model of inflammation-driven LSCC induced by N-nitroso-trischloroethylurea (NTCU) and enhanced by lipopolysaccharide (LPS), a potent pro-inflammatory agent contained in tobacco and tobacco smoke.
Before treatment of DIM, mice treated with the combination of NTCU and LPS had a 9-fold increase in the number of bronchioles with LSC.
Compared to mice treated with LPS alone, mice treated with NTCU plus LPS showed significantly increased expression of the pro-inflammatory cytokines, accompanied by the increased expression of proteins associated with the production of pro-inflammation and cancer cells initiation.
Pretreatment of DIM at a concentration of 0 μmol/g diet or 2,460 ppm) to mice treated with NTCU plus LPS reduced the incidence of LSCC by 2-fold and suppressed activation/expression of proinflammatory and procarcinogenic proteins without affecting the expression of cytokines and p53, a tumor suppressive gene.
In other words, DIM blocked the development of LSCC through cytotoxicity and gene associated with tumor suppression.
In order to reveal more information about DIM anti-lung cancer property, researchers looked into the anticancer efficacy of 1,1-bis (3'-indolyl)-1-(p-biphenyl) methane (DIM-C-pPhC₆H₅) inhalation delivery alone and in combination with i.v. docetaxel in a murine model.
According to assays, the lung weight reduction in mice treated with the drug combination was 64% compared with 40% and 47% in mice treated with DIM-C-pPhC₆H₅ aerosol and docetaxel alone, respectively.
The combination treatment inhibited the lung cancer by decreased expression of proteins associated with the pro-inflammatory cytokines, cancer cells survival, and proliferation through stimulating the production of the new blood vessels.
Furthermore, the combination also increased expression of genes involved autophagy in the tumor formation, compared to the tumor cell counts from single-agent treatment and control groups.
Dr. Ichite N, the lead scientist said, "These results suggest that DIM-C-pPhC₆H₅ aerosol enhanced the anticancer activity of docetaxel in a lung cancer model by activating multiple signaling pathways".
Taken altogether, 3,3'-Diindolylmethane may be considered a supplement for the prevention and combined with primary medicine for the treatment of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary diindolylmethane suppresses inflammation-driven lung squamous cell carcinoma in mice by Song JM1, Qian X1, Teferi F1, Pan J2, Wang Y2, Kassie F. (PubMed)
(2) Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer by Ichite N1, Chougule M, Patel AR, Jackson T, Safe S, Singh M. (PubMed)
(3) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)
Herbal Ginger, The Potential Anti Male Infertility Functional Remedy, Researchers Find
Infertility is a reproductive disease characterized by the failure to produce a pregnancy after 12 regular unprotected sexual intercourse, including pregnancy that can not be carried to term.
Infertility is very common in the US, approximately 10% of women or 6.1 million, ages 15-44 have difficulty getting pregnant or staying pregnant, according to the Centers for Disease Control and Prevention (CDC).
Believe it or not, only a very small number of such group are seeking help from the professionals.
In women, certain risk factors including age, excessive, or very low, body fat, medical conditions such as diabetes, hormone imbalance, previous miscarriage and unhealthy lifestyle, such as smoking, excessive alcohol consumption may affect the ovulation of a woman.
In men, age, pesticide and chemical exposure, drug use, radiation, pollution, cigarette or marijuana smoke, heavy alcohol consumption may be some risk factors for the onset of infertility.
In fact, some unfertilized women and men sometimes ago are fertile. However, here are some reasons that have found to increase the risk of infertility in the Western world, including
* Persuade a personal career, before having children.
*Try to be financial stability before having children.
* Too young to be a parent, raising a child needs efforts, time and money.
* Enjoy the couple childless years before committing.
Some researchers suggested that the widespread obesity in North America may be the major factors correlated to the increased infertile rate over the past few decades.
Dr. the lead scientist in the concern of obesity in the risk women infertility, wrote, "Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility".
And, "Overweight women have a higher incidence of menstrual dysfunction and anovulation. Overweight and obese women are at high risk for reproductive health. The risk of subfecundity and infertility, conception rates, miscarriage rates, and pregnancy complications are increased in these women".
The results suggested that if you are obese, your risk of infertility is higher compared to normal weight women
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine fro the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the course of the continued efforts to discover a natural remedy for the treatment of infertility, researchers investigated the ginger activity on male reproductive functions.
The randomized double-blind, placebo-controlled trial included 100 infertility treatment candidates admitted to Royan Institute for Reproductive Biomedicine, Tehran, Iran.
Patients were randomly assigned to receive one of two treatments: ginger and placebo. Patients were given a 3-month oral treatment (members received capsules containing 250 mg of ginger powder twice a day in ginger and a placebo in another group).
At the end of the experiment, according to the sperm DNA fragmentation (SDF) analysis, the ginger treatment group showed a significant lower of the average positive percentage of SDF compared to the placebo group.
However, there were no significant differences in other semen parameters between the two groups.
The finding clearly suggested that ginger improves the SDF profile in the infertile men.
In order to reveal more information about ginger anti-male infertility activity, researchers investigated the preventive effects of ginger and turmeric rhizomes on some biomarkers of male reproductive function in L-NAME-induced hypertensive rats.
Male Wistar rats selected to the study were divided into seven groups (n = 10): normotensive control rats; induced (L-NAME hypertensive) rats; hypertensive rats treated with atenolol (10 mg/kg/day); normotensive and hypertensive rats treated with 4% supplementation of turmeric or ginger, respectively.
After 14 days of pre-treatment, the animals were induced with hypertension by oral administration of L-NAME (40 mg/kg/day).
Application of L-NAME showed a significant decrease in serum total testosterone and epididymal sperm progressive motility without affecting sperm viability in hypertensive rats.
Hypertensive rats exerted an increase of oxidative stress by decreasing the level of antioxidant enzymes produced by the rats.
Furthermore, hypertensive rats also displayed a decreased testicular and epididymal NO level with concomitant elevation in arginase activity that affects the sperm counts.
Dietary supplementation with turmeric or ginger efficiently normalized the alterations in biomarkers of reproductive function in hypertensive rats.
Dr. Akinyemi AJ, and colleagues wrote, "The inhibition of arginase activity and increase in NO and testosterone levels by both rhizomes could suggest a possible mechanism of action for the prevention of male infertility in hypertension".
Taken altogether, ginger used alone or combined with turmeric may be considered functional remedies for the prevention and treatment of male infertility, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1)The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial by Hosseini J1, Mardi Mamaghani A2, Hosseinifar H2, Sadighi Gilani MA3, Dadkhah F2, Sepidarkish M4. (PubMed)
(2) Dietary supplementation of ginger and turmeric improves reproductive function in hypertensive male rats by Akinyemi AJ1,2,3, Adedara IA4,5, Thome GR3, Morsch VM3, Rovani MT6, Mujica LKS6, Duarte T7, Duarte M7, Oboh G1, Schetinger MRC3. (PubMed)
(3) Impact of obesity on infertility in women by Zeynep Özcan Dağ1 and Berna Dilbaz. (PMC)
Infertility is very common in the US, approximately 10% of women or 6.1 million, ages 15-44 have difficulty getting pregnant or staying pregnant, according to the Centers for Disease Control and Prevention (CDC).
Believe it or not, only a very small number of such group are seeking help from the professionals.
In women, certain risk factors including age, excessive, or very low, body fat, medical conditions such as diabetes, hormone imbalance, previous miscarriage and unhealthy lifestyle, such as smoking, excessive alcohol consumption may affect the ovulation of a woman.
In men, age, pesticide and chemical exposure, drug use, radiation, pollution, cigarette or marijuana smoke, heavy alcohol consumption may be some risk factors for the onset of infertility.
In fact, some unfertilized women and men sometimes ago are fertile. However, here are some reasons that have found to increase the risk of infertility in the Western world, including
* Persuade a personal career, before having children.
*Try to be financial stability before having children.
* Too young to be a parent, raising a child needs efforts, time and money.
* Enjoy the couple childless years before committing.
Some researchers suggested that the widespread obesity in North America may be the major factors correlated to the increased infertile rate over the past few decades.
Dr. the lead scientist in the concern of obesity in the risk women infertility, wrote, "Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility".
And, "Overweight women have a higher incidence of menstrual dysfunction and anovulation. Overweight and obese women are at high risk for reproductive health. The risk of subfecundity and infertility, conception rates, miscarriage rates, and pregnancy complications are increased in these women".
The results suggested that if you are obese, your risk of infertility is higher compared to normal weight women
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine fro the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the course of the continued efforts to discover a natural remedy for the treatment of infertility, researchers investigated the ginger activity on male reproductive functions.
The randomized double-blind, placebo-controlled trial included 100 infertility treatment candidates admitted to Royan Institute for Reproductive Biomedicine, Tehran, Iran.
Patients were randomly assigned to receive one of two treatments: ginger and placebo. Patients were given a 3-month oral treatment (members received capsules containing 250 mg of ginger powder twice a day in ginger and a placebo in another group).
At the end of the experiment, according to the sperm DNA fragmentation (SDF) analysis, the ginger treatment group showed a significant lower of the average positive percentage of SDF compared to the placebo group.
However, there were no significant differences in other semen parameters between the two groups.
The finding clearly suggested that ginger improves the SDF profile in the infertile men.
In order to reveal more information about ginger anti-male infertility activity, researchers investigated the preventive effects of ginger and turmeric rhizomes on some biomarkers of male reproductive function in L-NAME-induced hypertensive rats.
Male Wistar rats selected to the study were divided into seven groups (n = 10): normotensive control rats; induced (L-NAME hypertensive) rats; hypertensive rats treated with atenolol (10 mg/kg/day); normotensive and hypertensive rats treated with 4% supplementation of turmeric or ginger, respectively.
After 14 days of pre-treatment, the animals were induced with hypertension by oral administration of L-NAME (40 mg/kg/day).
Application of L-NAME showed a significant decrease in serum total testosterone and epididymal sperm progressive motility without affecting sperm viability in hypertensive rats.
Hypertensive rats exerted an increase of oxidative stress by decreasing the level of antioxidant enzymes produced by the rats.
Furthermore, hypertensive rats also displayed a decreased testicular and epididymal NO level with concomitant elevation in arginase activity that affects the sperm counts.
Dietary supplementation with turmeric or ginger efficiently normalized the alterations in biomarkers of reproductive function in hypertensive rats.
Dr. Akinyemi AJ, and colleagues wrote, "The inhibition of arginase activity and increase in NO and testosterone levels by both rhizomes could suggest a possible mechanism of action for the prevention of male infertility in hypertension".
Taken altogether, ginger used alone or combined with turmeric may be considered functional remedies for the prevention and treatment of male infertility, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1)The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial by Hosseini J1, Mardi Mamaghani A2, Hosseinifar H2, Sadighi Gilani MA3, Dadkhah F2, Sepidarkish M4. (PubMed)
(2) Dietary supplementation of ginger and turmeric improves reproductive function in hypertensive male rats by Akinyemi AJ1,2,3, Adedara IA4,5, Thome GR3, Morsch VM3, Rovani MT6, Mujica LKS6, Duarte T7, Duarte M7, Oboh G1, Schetinger MRC3. (PubMed)
(3) Impact of obesity on infertility in women by Zeynep Özcan Dağ1 and Berna Dilbaz. (PMC)
Wednesday, May 1, 2019
Honey Protects the Bone Mass with No Side Effect, According to Studies
Bone is a hard whitish tissue making up the skeleton in humans which provides a framework for the attachment of muscles and other tissues.
Bone density is the amount of bone mineral in bone tissue. Loss of bone density is found to induce osteoporosis.
Bone density is measured by the young adult bone density mean within 1 standard deviation (+1 or −1). The negative T-score is an indication of loss or lower bone density and the T-score of −2.5 or lower is an indication of osteoporosis.
Risk factors of losing bone density include gender, (women are more likely to develop osteoporosis compared to men) the increase in age, race, (African Americans have both lower rates of bone density loss and osteoporosis), family history.
People with low bone mass accompanied by progressive bone density loss over time are associated with an increased risk of developing osteoporosis.
Low bone mass is a risk factor of osteoporosis, The condition may also increase the incidence of bone fracture if it is accompanied by other risk factors.
Some researchers suggested that people who follow a healthy diet pattern are less likely to develop osteoporosis.
Dr. Małgorzata Kostecka in the examination of the role of a healthy diet in the prevention of osteoporosis in perimenopausal period, wrote, "Diet of a large part of society is not properly balanced which can cause abnormalities in achieving proper bone mineralization. Long-term deficiencies in calcium and vitamin D in daily diet are the cause of taking dietary supplements".
And, "Changes in the nutritional regimen are required already during childhood because nutritional mistakes are the main cause of diet-related diseases in adulthood".
The results indicated a link to an unhealthy diet in the risk of osteoporosis.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on finding a natural remedy for the protection of bone structure investigated the honey effects on the cessation of exercise on bone properties in young female rats.
The experiment included a total of eighty four 12-week-old Sprague-Dawley female rats randomly divided into 7 groups: 16S, 16J, 16H, 16JH, 8J8S, 8H8S, and 8JH8S (8 = 8 weeks, 16 = 16 weeks, S = sedentary without honey supplementation, H = honey supplementation, and J = jumping exercise).
Jumping exercise consisted of 40 jumps/day for 5 days/week and honey was given to the rats at a dosage of 1 g/kg body weight/rat/day via force feeding for 7 days/week.
After 8 weeks of cessation of exercise, honey supplementation groups (8JH) showed higher tibial energy, proximal total bone density, a midshaft cortical moment of inertia, and cortical area, compared to 16S.
Continuous sixteen weeks of combined jumping and honey group (16JH) exerted a significant greater tibial maximum force, energy, proximal total bone density, proximal trabecular bone density, midshaft cortical bone density, cortical area, and midshaft cortical moment of inertia, compared to 16S.
Dr. Tavafzadeh SS, the lead scientist said, "the beneficial effects of 8 weeks of combined exercise and honey supplementation still can be observed after 8 weeks of the cessation and exercise and supplementation".
In other words, these comparative results suggested that long term combined exercise and honey supplementation may have a long term effect on the bone structure, even after the cessation of exercise and honey supplementation.
In order to reveal more information about honey effects on bone structure, researchers examined the jumping exercise intensities combined with honey on bone and gonadotrophins in an animal model.
The experimental groups selected to the study were required to exercise 20 or 80 jumps per day combined with or without honey supplementation (HJ20, HJ80, J20, and J80), Oher groups selected to the study also included honey supplementation (H), sedentary without supplementation control (C), and baseline control (C0) groups.
HJ80 showed the greatest beneficial effects on tibial and femoral mass, serum total calcium and alkaline phosphatase concentrations, compared to the lower levels of serum follicle stimulating hormone concentrations in H, J20, J80, particularly in the C group.
Furthermore, the serum luteinizing hormone concentrations were significantly (p < 0.05) greater in HJ20, HJ80 and J20 compared to J80.
The surprising result indicated moderate jumping exercise combined with honey supplementation may have a better effect compared to high-intensity exercise + honey supplement on bone mass and density.
Moreover, honey may have protection against the adverse effects induced by jumping exercise on gonadotropins in female rats.
Taken altogether, honey may be considered a functional remedy for the protection of bone mass regardless of the types of exercise, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bone Mechanical Properties and Mineral Density in Response to Cessation of Jumping Exercise and Honey Supplementation in Young Female Rats by Tavafzadeh SS1, Ooi FK1, Chen CK1, Sulaiman SA2, Hung LK. (PubMed)
(2) Effects of honey supplementation combined with different jumping exercise intensities on bone mass, serum bone metabolism markers and gonadotropins in female rats by Mosavat M, Ooi FK1, Mohamed M. (PubMed)
(3) The role of healthy diet in the prevention of osteoporosis in perimenopausal period by Małgorzata Kostecka. (PMC)
Bone density is the amount of bone mineral in bone tissue. Loss of bone density is found to induce osteoporosis.
Bone density is measured by the young adult bone density mean within 1 standard deviation (+1 or −1). The negative T-score is an indication of loss or lower bone density and the T-score of −2.5 or lower is an indication of osteoporosis.
Risk factors of losing bone density include gender, (women are more likely to develop osteoporosis compared to men) the increase in age, race, (African Americans have both lower rates of bone density loss and osteoporosis), family history.
People with low bone mass accompanied by progressive bone density loss over time are associated with an increased risk of developing osteoporosis.
Low bone mass is a risk factor of osteoporosis, The condition may also increase the incidence of bone fracture if it is accompanied by other risk factors.
Some researchers suggested that people who follow a healthy diet pattern are less likely to develop osteoporosis.
Dr. Małgorzata Kostecka in the examination of the role of a healthy diet in the prevention of osteoporosis in perimenopausal period, wrote, "Diet of a large part of society is not properly balanced which can cause abnormalities in achieving proper bone mineralization. Long-term deficiencies in calcium and vitamin D in daily diet are the cause of taking dietary supplements".
And, "Changes in the nutritional regimen are required already during childhood because nutritional mistakes are the main cause of diet-related diseases in adulthood".
The results indicated a link to an unhealthy diet in the risk of osteoporosis.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on finding a natural remedy for the protection of bone structure investigated the honey effects on the cessation of exercise on bone properties in young female rats.
The experiment included a total of eighty four 12-week-old Sprague-Dawley female rats randomly divided into 7 groups: 16S, 16J, 16H, 16JH, 8J8S, 8H8S, and 8JH8S (8 = 8 weeks, 16 = 16 weeks, S = sedentary without honey supplementation, H = honey supplementation, and J = jumping exercise).
Jumping exercise consisted of 40 jumps/day for 5 days/week and honey was given to the rats at a dosage of 1 g/kg body weight/rat/day via force feeding for 7 days/week.
After 8 weeks of cessation of exercise, honey supplementation groups (8JH) showed higher tibial energy, proximal total bone density, a midshaft cortical moment of inertia, and cortical area, compared to 16S.
Continuous sixteen weeks of combined jumping and honey group (16JH) exerted a significant greater tibial maximum force, energy, proximal total bone density, proximal trabecular bone density, midshaft cortical bone density, cortical area, and midshaft cortical moment of inertia, compared to 16S.
Dr. Tavafzadeh SS, the lead scientist said, "the beneficial effects of 8 weeks of combined exercise and honey supplementation still can be observed after 8 weeks of the cessation and exercise and supplementation".
In other words, these comparative results suggested that long term combined exercise and honey supplementation may have a long term effect on the bone structure, even after the cessation of exercise and honey supplementation.
In order to reveal more information about honey effects on bone structure, researchers examined the jumping exercise intensities combined with honey on bone and gonadotrophins in an animal model.
The experimental groups selected to the study were required to exercise 20 or 80 jumps per day combined with or without honey supplementation (HJ20, HJ80, J20, and J80), Oher groups selected to the study also included honey supplementation (H), sedentary without supplementation control (C), and baseline control (C0) groups.
HJ80 showed the greatest beneficial effects on tibial and femoral mass, serum total calcium and alkaline phosphatase concentrations, compared to the lower levels of serum follicle stimulating hormone concentrations in H, J20, J80, particularly in the C group.
Furthermore, the serum luteinizing hormone concentrations were significantly (p < 0.05) greater in HJ20, HJ80 and J20 compared to J80.
The surprising result indicated moderate jumping exercise combined with honey supplementation may have a better effect compared to high-intensity exercise + honey supplement on bone mass and density.
Moreover, honey may have protection against the adverse effects induced by jumping exercise on gonadotropins in female rats.
Taken altogether, honey may be considered a functional remedy for the protection of bone mass regardless of the types of exercise, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bone Mechanical Properties and Mineral Density in Response to Cessation of Jumping Exercise and Honey Supplementation in Young Female Rats by Tavafzadeh SS1, Ooi FK1, Chen CK1, Sulaiman SA2, Hung LK. (PubMed)
(2) Effects of honey supplementation combined with different jumping exercise intensities on bone mass, serum bone metabolism markers and gonadotropins in female rats by Mosavat M, Ooi FK1, Mohamed M. (PubMed)
(3) The role of healthy diet in the prevention of osteoporosis in perimenopausal period by Małgorzata Kostecka. (PMC)
Herbal Artichoke In the Promotion of Digestive Health
The digestive system is an organ consists of the gastrointestinal tract and other organs associated with digestive functioning including the salivary glands, pancreas, liver, and gallbladder.
Digestion is a process of breaking down foods into a smaller and smaller portion that can be absorbed and assimilated into the body.
Digestive disorders can be caused by the digestive problem or some underlying diseases, including GERD, IBS,...
Most common symptoms of digestive disorders include bloating, constipation, diarrhea, heartburn. fecal incontinence.and pain in the belly.
Although there are many risk factors associated with the onset of digestive problems, some researchers suggested that the promotion of the Western diet may have a strong implication in the induction of digestive disorders.
Dr. Marit K. Zinöcker, the lead scientist in the investigation of the Western diet and Microbiome wrote, "the Western diet promotes inflammation that arises from both structural and behavioral changes in the resident microbiome".
And, " The environment created in the gut by ultra-processed foods, a hallmark of the Western diet, is an evolutionarily unique selection ground for microbes that can promote diverse forms of inflammatory disease".
The findings clearly explained the negative impact of the Western diet in the alternation of the ratio of gut microbes, leading to digestive disorders in the initiation of chronic diseases.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Scientists on finding a natural remedy for the improvement of digestive function examined whether the consumption of artichokes enriched with a probiotic Lactobacillus paracasei strain affects fecal microbiota composition and other symptoms associated with chronic constipation.
The study included 8 volunteers (3M/5F age 40+/-14 y) integrated their normal diet with artichokes (180 gr) enriched with 20 billions of L. paracasei LMGP22043.
According to tested assays, additional artichoke diet exerted a strong effect in promotion of the colonized by the probiotic strain in all volunteers' gut, after 15 days of feeding.
Injection of artichoke also demonstrated a significant increase of butyric and valeric acids with a decrease of lactic acid, the indications of improvement of gut microbiota.
The diet integrated with artichoke also resolved the constipation symptoms by reducing the fecal beta-glucuronidase activity.
Interestingly, according to the analysis of symptom profile, there was a marked reduction in abdominal distension and feeling of incomplete evacuation in volunteers with constipation problems.
The results suggested that included artichoke in a diet promotes a healthy digestive system by balancing the ratio of gut microbiota.
In order to reveal more information about artichoke enhanced the function of the gastrointestinal tract, researchers investigated the effects of Jerusalem artichoke inulin (JA) or chicory inulin (CH) in snack bars on composition fecal microbiota, the concentration of fecal SCFA, bowel habit and gastrointestinal symptoms.
45 volunteers were selected to a double-blind, randomized, placebo-controlled, parallel-group study.
After a 7 days run-in period, subjects were randomly assigned to three groups of fifteen subjects each, consuming either snack bars with CH or JA, or snack bars without fructans (placebo); for 7 d (adaptation period), they ingested one snack bar per day (7.7 g fructan/d) and continued for 14 d with two snack bars per day.
At the end of the intervention, consumption of CH or JA improved the ratio of gut microbiota by increasing the counts of good bacterias such as bifidobacteria (+1.2 log10 in 21 d) and decreasing the counts of bad bacteria such as Bacteroides/Prevotella and Clostridium histolyticum/C. lituseburense group in frequency.
Consumption of CH or JA also resulted in mild and moderate flatulence in a few subjects compared to placebo with a slight effected of tool consistency.
Dr. Kleessen B, the lead scientist said, "...adaptation on increased doses of CH or JA in bakery products stimulates the growth of bifidobacteria and may contribute to the suppression of potentially pathogenic bacteria".
Taken altogether, artichoke alone and combined with other herbal remedies may be considered functional remedies for the treatment of the digestive disorder, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of probiotic Lactobacillus paracasei-enriched artichokes on constipated patients: a pilot study by Valerio F1, Russo F, de Candia S, Riezzo G, Orlando A, Lonigro SL, Lavermicocca P. (PubMed)
(2) Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers by Kleessen B1, Schwarz S, Boehm A, Fuhrmann H, Richter A, Henle T, Krueger M.(PubMed)
(3) The Western Diet-Microbiome-Host Interaction and Its Role in Metabolic Disease by Zinöcker MK1, Lindseth IA. (PubMed)
Digestion is a process of breaking down foods into a smaller and smaller portion that can be absorbed and assimilated into the body.
Digestive disorders can be caused by the digestive problem or some underlying diseases, including GERD, IBS,...
Most common symptoms of digestive disorders include bloating, constipation, diarrhea, heartburn. fecal incontinence.and pain in the belly.
Although there are many risk factors associated with the onset of digestive problems, some researchers suggested that the promotion of the Western diet may have a strong implication in the induction of digestive disorders.
Dr. Marit K. Zinöcker, the lead scientist in the investigation of the Western diet and Microbiome wrote, "the Western diet promotes inflammation that arises from both structural and behavioral changes in the resident microbiome".
And, " The environment created in the gut by ultra-processed foods, a hallmark of the Western diet, is an evolutionarily unique selection ground for microbes that can promote diverse forms of inflammatory disease".
The findings clearly explained the negative impact of the Western diet in the alternation of the ratio of gut microbes, leading to digestive disorders in the initiation of chronic diseases.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Scientists on finding a natural remedy for the improvement of digestive function examined whether the consumption of artichokes enriched with a probiotic Lactobacillus paracasei strain affects fecal microbiota composition and other symptoms associated with chronic constipation.
The study included 8 volunteers (3M/5F age 40+/-14 y) integrated their normal diet with artichokes (180 gr) enriched with 20 billions of L. paracasei LMGP22043.
According to tested assays, additional artichoke diet exerted a strong effect in promotion of the colonized by the probiotic strain in all volunteers' gut, after 15 days of feeding.
Injection of artichoke also demonstrated a significant increase of butyric and valeric acids with a decrease of lactic acid, the indications of improvement of gut microbiota.
The diet integrated with artichoke also resolved the constipation symptoms by reducing the fecal beta-glucuronidase activity.
Interestingly, according to the analysis of symptom profile, there was a marked reduction in abdominal distension and feeling of incomplete evacuation in volunteers with constipation problems.
The results suggested that included artichoke in a diet promotes a healthy digestive system by balancing the ratio of gut microbiota.
In order to reveal more information about artichoke enhanced the function of the gastrointestinal tract, researchers investigated the effects of Jerusalem artichoke inulin (JA) or chicory inulin (CH) in snack bars on composition fecal microbiota, the concentration of fecal SCFA, bowel habit and gastrointestinal symptoms.
45 volunteers were selected to a double-blind, randomized, placebo-controlled, parallel-group study.
After a 7 days run-in period, subjects were randomly assigned to three groups of fifteen subjects each, consuming either snack bars with CH or JA, or snack bars without fructans (placebo); for 7 d (adaptation period), they ingested one snack bar per day (7.7 g fructan/d) and continued for 14 d with two snack bars per day.
At the end of the intervention, consumption of CH or JA improved the ratio of gut microbiota by increasing the counts of good bacterias such as bifidobacteria (+1.2 log10 in 21 d) and decreasing the counts of bad bacteria such as Bacteroides/Prevotella and Clostridium histolyticum/C. lituseburense group in frequency.
Consumption of CH or JA also resulted in mild and moderate flatulence in a few subjects compared to placebo with a slight effected of tool consistency.
Dr. Kleessen B, the lead scientist said, "...adaptation on increased doses of CH or JA in bakery products stimulates the growth of bifidobacteria and may contribute to the suppression of potentially pathogenic bacteria".
Taken altogether, artichoke alone and combined with other herbal remedies may be considered functional remedies for the treatment of the digestive disorder, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of probiotic Lactobacillus paracasei-enriched artichokes on constipated patients: a pilot study by Valerio F1, Russo F, de Candia S, Riezzo G, Orlando A, Lonigro SL, Lavermicocca P. (PubMed)
(2) Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers by Kleessen B1, Schwarz S, Boehm A, Fuhrmann H, Richter A, Henle T, Krueger M.(PubMed)
(3) The Western Diet-Microbiome-Host Interaction and Its Role in Metabolic Disease by Zinöcker MK1, Lindseth IA. (PubMed)
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