Cancer is the class of diseases associated with cell growth, disorderly and uncontrollably due to the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining tissues of organ or gland. At the early stage, most cancers are asymptomatic.
However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.
Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.
The causes of cancer are unknown. age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormones therapy, use of immunosuppression are some of the prevalent factors involved the onset of cancer.
However, most people with some of the aforementioned risk factors have never developed cancer.
Some researchers suggested that the rise of cancers in the obese individual may correlate to the promotion of the Western diet over the past few decades.
Dr.Timothy J Key, the lead scientist wrote, "Diet-related factors are thought to account for about 30% of cancers in developed countries. Obesity increases the risk of cancers in the esophagus, colorectum, breast, endometrium, and kidney. Alcohol causes cancers of the oral cavity, pharynx, larynx, esophagus, and liver, and causes a small increase in the risk of breast cancer".
And, "Adequate intakes of fruit and vegetables probably lower the risk for several types of cancer, especially cancers of the gastrointestinal tract".
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a natural ingredient which reduces the side effects of potent anticancer drugs e.g. doxorubicin (DOX) on the normal tissues, researchers examined betanin (BET) effect in the co-administration with them.
In the study to overcome the restrictions of BET, researchers designed a new pH-responsive nanocarrier via decoration of gelatin nanoparticles (GNPs) by (methoxy poly (ethylene glycol)-poly ((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (PGNPs) for the DOX and BET loading capacity of 20.5% and 16.25%, respectively).
Injection of DOX@BET loaded PGNPs decreased the significant cell viability amount of breast cancer cells (MCF-7) compared to the treatment of the free form of DOX or BET.
In other words, the newly designed combination kills induce a higher percentage of cell death compared to the use of DOX or BET individually.
Sadly, the study did not confirm the combination reduced the side effect caused by DOX during the experiment.
Dr. Javadi B in the examination of herbal plants for the treatment of breast cancer showed that beetroot (Beta vulgris) induced cancer death by cytotoxicity without affecting the nearby healthy cells.
He continued, "additional pharmacological studies and clinical trials are needed to elucidate their molecular and cellular mechanisms of actions, frequency, and amount of consumption, possible adverse effects, and optimum preparation methods.".
Taken altogether, betanin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy by Amjadi S1, Hamishehkar H2, Ghorbani M. (PubMed)
(2) Diet Therapy for Cancer Prevention and Treatment Based on Traditional Persian Medicine by Javadi B. (PubMed)
(3) The effect of diet on risk of cancer by Dr. Timothy J Key, Naomi E Allen, Elizabeth A Spencer,
Ruth C Travis. (The Lancet)
Friday, May 10, 2019
Cucumbers (Cucumis sativus) Bioactive Compound Cucurbitacin B (CuB) Kills Melanoma in Vitro
Melanoma is a type of skin cancer associated with the alternation of DNA in the pigment-containing cells.
The melanin is a pigment that gives skin, hair, and eyes their color.
Malignant melanin cells (melanocytes) lead to the formation of moles on the skin with usually brown or pink color.
Skin is the largest organ in the body which not only processes a unique function by protecting our body through its covering but also is a third detoxed organ that eliminates toxins from our body in cases the kidney and liver fail.
Epidemiologically, certain risk factors such as exposure to ultraviolet radiation (UVR), genetic preposition such as CDKN2A gene mutation, people with light color skin, personal and family history of skin cancer are associated with the onset melanoma.
However, most people with some of the aforementioned risk factors have not developed melanoma.
Out of many risk factors, long-term contact with ultraviolet radiation (UVR) is the most common risk factor found in skin cancer in the US.
Dr. Wang SQ, the lead scientist at the New York University School of Medicine, wrote, "The incidence and mortality rates of melanoma have risen for many decades in the United States. Increased exposure to ultraviolet (UV) radiation is generally considered to be responsible. Sunburns, a measure of excess sun exposure, have been identified as a risk factor for the development of melanoma".
And, "Because sunburns are primarily due to UVB (280-320 nm) radiation, UVB has been implicated as a potential contributing factor to the pathogenesis of melanoma. The adverse role of UVA (320-400 nm) in this regard is less well studied".
Cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a potential compound for the treatment of cancer, researchers examined the effects of Cucurbitacin B (CuB), a triterpenoid compound isolated from cucumber, against melanoma B16 cell.
According to the tested assays, CuB exerted significant inhibitory effects on cell proliferation, colony formation, cell migration and invasion potential of the melanoma cells.
In vivo, CuB significantly inhibited the growth of subcutaneous melanoma in mice compared to control.
Furthermore, injection of CuB treatment induced rapid cancer cell membrane blebbing and deformation and induced G(2)/M-phase arrest and cell proliferation.
Moreover, CuB also induced overexpression of ROS in facilitating the cytotoxic activity against the tested cell lines through rapid depletion of the protein involved the formation of microfilaments.
Dr. Zhang Y, the lead scientist said, " These findings indicate that CuB induces rapid depletion of the G-actin pool through ROS-dependent actin aggregation in melanoma cells, which may at least partly account for its anti-tumor activity".
Additonally, CuB inhibited the proliferation of the cell line was found to be in a dose-dependent manner, involving the induction of autophagy and exhibited the function of a protein associated with anti-apoptosis.
Combined with chloroquine, a well-known autophagy inhibitor, the combination showed more sensitive to the tested melanoma cells.
In other words, CuB improved the efficacy of chloroquine against melanoma while reducing the medicine side effects.
Taken altogether, cucumber processed a high amount of CuB may be considered a natural remedy for the prevention and treatment of melanoma, pending to the confirmation of larger sample size and multicenter human study
Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells by Zhang Y1, Ouyang D, Xu L, Ji Y, Zha Q, Cai J, He X. (PubMed)
(2) Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment by Ouyang D1, Zhang Y, Xu L, Li J, Zha Q, He X. (PubMed)
(3) Ultraviolet A and melanoma: a review by Wang SQ1, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW, Bart RS. (PubMed)
The melanin is a pigment that gives skin, hair, and eyes their color.
Malignant melanin cells (melanocytes) lead to the formation of moles on the skin with usually brown or pink color.
Skin is the largest organ in the body which not only processes a unique function by protecting our body through its covering but also is a third detoxed organ that eliminates toxins from our body in cases the kidney and liver fail.
Epidemiologically, certain risk factors such as exposure to ultraviolet radiation (UVR), genetic preposition such as CDKN2A gene mutation, people with light color skin, personal and family history of skin cancer are associated with the onset melanoma.
However, most people with some of the aforementioned risk factors have not developed melanoma.
Out of many risk factors, long-term contact with ultraviolet radiation (UVR) is the most common risk factor found in skin cancer in the US.
Dr. Wang SQ, the lead scientist at the New York University School of Medicine, wrote, "The incidence and mortality rates of melanoma have risen for many decades in the United States. Increased exposure to ultraviolet (UV) radiation is generally considered to be responsible. Sunburns, a measure of excess sun exposure, have been identified as a risk factor for the development of melanoma".
And, "Because sunburns are primarily due to UVB (280-320 nm) radiation, UVB has been implicated as a potential contributing factor to the pathogenesis of melanoma. The adverse role of UVA (320-400 nm) in this regard is less well studied".
Cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a potential compound for the treatment of cancer, researchers examined the effects of Cucurbitacin B (CuB), a triterpenoid compound isolated from cucumber, against melanoma B16 cell.
According to the tested assays, CuB exerted significant inhibitory effects on cell proliferation, colony formation, cell migration and invasion potential of the melanoma cells.
In vivo, CuB significantly inhibited the growth of subcutaneous melanoma in mice compared to control.
Furthermore, injection of CuB treatment induced rapid cancer cell membrane blebbing and deformation and induced G(2)/M-phase arrest and cell proliferation.
Moreover, CuB also induced overexpression of ROS in facilitating the cytotoxic activity against the tested cell lines through rapid depletion of the protein involved the formation of microfilaments.
Dr. Zhang Y, the lead scientist said, " These findings indicate that CuB induces rapid depletion of the G-actin pool through ROS-dependent actin aggregation in melanoma cells, which may at least partly account for its anti-tumor activity".
Additonally, CuB inhibited the proliferation of the cell line was found to be in a dose-dependent manner, involving the induction of autophagy and exhibited the function of a protein associated with anti-apoptosis.
Combined with chloroquine, a well-known autophagy inhibitor, the combination showed more sensitive to the tested melanoma cells.
In other words, CuB improved the efficacy of chloroquine against melanoma while reducing the medicine side effects.
Taken altogether, cucumber processed a high amount of CuB may be considered a natural remedy for the prevention and treatment of melanoma, pending to the confirmation of larger sample size and multicenter human study
Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells by Zhang Y1, Ouyang D, Xu L, Ji Y, Zha Q, Cai J, He X. (PubMed)
(2) Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment by Ouyang D1, Zhang Y, Xu L, Li J, Zha Q, He X. (PubMed)
(3) Ultraviolet A and melanoma: a review by Wang SQ1, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW, Bart RS. (PubMed)
Thursday, May 9, 2019
Tomato Improves Sleep Quality by Enhancing Levels of Melatonin
In other words, sleep is the state in which human reduced interactions with the outside world.
The human sleep recurrently to reenergize their body so that when awake they can carry out a daily activity without feeling tired or weak.
In the brain, sleep helps to maintain the pathways associated with the brain function such as learning and studying. A recent study suggested, sleep helps to remove toxins in the brain that was built up when awake.
Believe it or not, we spend about one-third of our life sleeping.
Sleep disorders are syndromes associated negatively with the changes in the sleep pattern, including insomnia, one of the most common causes of disease disorders in the US, found in 30% of adults, including 10% of chronic insomnia is a condition of difficulty falling asleep or staying asleep throughout the night.
According to the statistics, 50-70 million US adults have a sleep disorder including 37.9% reported unintentionally falling asleep during the day.
Sleep disorders have been found to have a strong implication on economic cost. Dr. Hillman DR, the lead scientist at the Sir Charles Gairdner Hospital wrote, "The overall cost of sleep disorders in Australia in 2004 (population: 20.1 million) was dollar 7494 million".
And, "The direct and indirect costs of sleep disorders are high. The total financial costs (independent of the cost of suffering) of dollar 4524 million represents 0.8% of Australian gross domestic product. The cost of suffering of dollar 2970 million is 1.4% of the total burden of disease in Australia".
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding a natural and potential compound for the improvement of sleep quality, researchers investigated the effect of tomato intake before bed on obese postmenopausal women's urinary 6-sulphatoxymelatonin (aMT6s) level, a reliable surrogate biomarker reflecting the blood melatonin concentration and sleep quality.
The study is an 8-week open-label, randomized controlled dietary intervention trial included 36 subjects completed the entire trial.
In the tomato group, participants ate 250 g of beefsteak tomatoes 2 h before sleep for 8 weeks.
After 8 weeks, by comparing the blood and urine samples collected at the baseline and in the 8th week, researchers found at 8 weeks of the beefsteak intervention, improved all components of all components the PSQI compared to the Pittsburgh Sleep Quality Index (PSQI) before treatment.
Furthermore, tomatoes and beefsteak intervention also improved the levels of aMT6s level by 10-fold compared that of the control group.
In other words, tomato combined with beefsteak improved the sleep quality of the participants.
These results strongly suggested that tomato enhanced the levels of melatonin in the beef substantially in the improvement of sleep quality.
Dr. Yang TH, the lead scientist at the Taipei Medical University wrote in the final report, "supplementation with beefsteak tomato before sleep can increase circulating melatonin and improve sleep quality in obese postmenopausal women".
Taken altogether, tomatoes combined with beefsteak may be considered treatment to improve sleep quality, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary supplement of tomato can accelerate urinary aMT6s level and improve sleep quality in obese postmenopausal women by Yang TH1, Chen YC1, Ou TH1, Chien YW. (PubMed)
(2) The economic cost of sleep disorders by Hillman DR1, Murphy AS, Pezzullo L. (PubMed)
Herbal Ginger, the Potential Anti Hyperlipidemia Functional Remedy, Researchers Find
Hyperlipidemia is abnormally high levels of cholesterol in the bloodstream. The syndrome is a member of the cluster conditions of metabolic syndrome, a leading cause of cardiovascular disease.
Cholesterol, a waxy substance produced either by the liver or food intake plays a critical role in the production of vitamin D, steroid hormones and the building of the cell walls.
Overexpression cholesterol is a medical condition which causes plaque accumulated on the arterial wall, leading to narrowing the arteries in transport the oxygenated blood to the parts of the body.
In severe cases, it can cause blood flow blockage, leading to chronic ailments depending on the location of the blood clot.
There are 2 types of blood cholesterol, the low-density lipoprotein (LDL) which carries the aforementioned functions and the high-density cholesterol (HDL) which carries cholesterol from the blood back to the liver for the future re-use.
The healthy ratio of total blood cholesterol is less than 4 LDL/ 1 HDL.
Most people diagnosed with high blood cholesterol substantially higher total cholesterol ratio.
Some researchers suggested that the widespread high blood cholesterol in North America is associated with the promotion of the Western diet over the past few decades.
Dr. Kamilah Ali, the lead scientist in the assessment of the Western diet risk of high blood cholesterol in an animal model, wrote, "mice on a C57BL/6 background after receiving a high fat-high cholesterol diet for 12 weeks. ApoD−/− mice had higher HDL-cholesterol levels (61±13-apoD−/− vs. 52±10-WT-males; 37±11-apoD−/− vs. 22±2 WT-female) than WT mice with sex-specific changes in total plasma levels of cholesterol and other lipids".
And, "Compared to WT, the HDL of apoD−/− mice showed an increase in large, lipid-rich HDL particles and according to size various quantities and sizes of LDL particles".
The results suggested that long-term users of the Western diet may be associated with the risk of hyperlipidemia.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the trerament dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of hyperlipidemia investigated the effect of ginger extracts on alcohol-induced hyperlipidemia and associated myocardial damage.
The study included 24 Wistar male albino rats (250 ± 20 g) divided into four groups including, normal control (NC) (0.9% NaCl), ginger treated (Gt) (200 mg/Kg b.w.), alcohol-treated (At) (20% of 6g/kg b.w. alcohol), and alcohol along with Ginger treatment (At+Gt).
Before ginger administration, alcohol-induced myocardial damage rats showed an increased lipid profile except for high-density lipoprotein compared with control.
Ginger treatment significantly inhibited the alcohol-induced lipid profiles caused by the injection of alcohol except for high-density lipoproteins.
Furthermore, ginger treatment also inhibited the elevated cardiac biomarkers activity with alcohol intoxication. In other words, ginger treatment for 7-weeks significantly minimized the alcohol-induced myocardial damage.
Dr. Subbaiah GV, the lead scientist said, "ginger could protect alcohol-induced myocardial damage by suppression of hyperlipidemia and cardiac biomarkers".
In order to reveal more information about ginger anti hypolipidemic effects, researchers examined the hypolipidemic effects of a hydroethanolic ginger extract (GE) in the liver of rats fed a high-fat diet (HFD).
The study included male Wistar rats divided into the following 3 groups: (i) Rats fed a standard diet (3.5% fat), the control group; (ii) rats fed an HFD (33.5% fat); and (iii) rats fed an HFD treated with GE (250 mg·kg-1·day-1) for 5 weeks (HFD+GE).
GE improved lipid profile and attenuated the increase of plasma levels of glucose, insulin, and leptin in HFD rats.
In the depth analysis, researchers found that ginger antihyperlipidemic activity was attributed to the induction of a higher liver expression of proteins associated with a variety of metabolic processes including lipid and enhanced levels of adiponectin which plays a critical role in preventing dyslipidemia.
Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of hyperlipidemia with no side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Ginger Treatment Ameliorates Alcohol-induced Myocardial Damage by Suppression of Hyperlipidemia and Cardiac Biomarkers in Rats by Subbaiah GV1, Mallikarjuna K2, Shanmugam B1, Ravi S1, Taj PU1, Reddy KS1. (PubMed)
(2) Molecular factors involved in the hypolipidemic- and insulin-sensitizing effects of a ginger (Zingiber officinale Roscoe) extract in rats fed a high-fat diet by de Las Heras N1, Valero-Muñoz M1, Martín-Fernández B1, Ballesteros S1, López-Farré A2, Ruiz-Roso B3, Lahera V1. (PubMed)
(3) A Western-Fed Diet Increases Plasma HDL and LDL-Cholesterol Levels in ApoD–/– Mice by Kamilah Ali, Ehab M. Abo-Ali, M. D. Kabir, 1 Bethany Riggins, 1 Susanna Nguy, 1Lisa Li, 1 Ujala Srivastava, 1 and Su Mya Mya Thinn. (PMC)
Cholesterol, a waxy substance produced either by the liver or food intake plays a critical role in the production of vitamin D, steroid hormones and the building of the cell walls.
Overexpression cholesterol is a medical condition which causes plaque accumulated on the arterial wall, leading to narrowing the arteries in transport the oxygenated blood to the parts of the body.
In severe cases, it can cause blood flow blockage, leading to chronic ailments depending on the location of the blood clot.
There are 2 types of blood cholesterol, the low-density lipoprotein (LDL) which carries the aforementioned functions and the high-density cholesterol (HDL) which carries cholesterol from the blood back to the liver for the future re-use.
The healthy ratio of total blood cholesterol is less than 4 LDL/ 1 HDL.
Most people diagnosed with high blood cholesterol substantially higher total cholesterol ratio.
Some researchers suggested that the widespread high blood cholesterol in North America is associated with the promotion of the Western diet over the past few decades.
Dr. Kamilah Ali, the lead scientist in the assessment of the Western diet risk of high blood cholesterol in an animal model, wrote, "mice on a C57BL/6 background after receiving a high fat-high cholesterol diet for 12 weeks. ApoD−/− mice had higher HDL-cholesterol levels (61±13-apoD−/− vs. 52±10-WT-males; 37±11-apoD−/− vs. 22±2 WT-female) than WT mice with sex-specific changes in total plasma levels of cholesterol and other lipids".
And, "Compared to WT, the HDL of apoD−/− mice showed an increase in large, lipid-rich HDL particles and according to size various quantities and sizes of LDL particles".
The results suggested that long-term users of the Western diet may be associated with the risk of hyperlipidemia.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the trerament dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of hyperlipidemia investigated the effect of ginger extracts on alcohol-induced hyperlipidemia and associated myocardial damage.
The study included 24 Wistar male albino rats (250 ± 20 g) divided into four groups including, normal control (NC) (0.9% NaCl), ginger treated (Gt) (200 mg/Kg b.w.), alcohol-treated (At) (20% of 6g/kg b.w. alcohol), and alcohol along with Ginger treatment (At+Gt).
Before ginger administration, alcohol-induced myocardial damage rats showed an increased lipid profile except for high-density lipoprotein compared with control.
Ginger treatment significantly inhibited the alcohol-induced lipid profiles caused by the injection of alcohol except for high-density lipoproteins.
Furthermore, ginger treatment also inhibited the elevated cardiac biomarkers activity with alcohol intoxication. In other words, ginger treatment for 7-weeks significantly minimized the alcohol-induced myocardial damage.
Dr. Subbaiah GV, the lead scientist said, "ginger could protect alcohol-induced myocardial damage by suppression of hyperlipidemia and cardiac biomarkers".
In order to reveal more information about ginger anti hypolipidemic effects, researchers examined the hypolipidemic effects of a hydroethanolic ginger extract (GE) in the liver of rats fed a high-fat diet (HFD).
The study included male Wistar rats divided into the following 3 groups: (i) Rats fed a standard diet (3.5% fat), the control group; (ii) rats fed an HFD (33.5% fat); and (iii) rats fed an HFD treated with GE (250 mg·kg-1·day-1) for 5 weeks (HFD+GE).
GE improved lipid profile and attenuated the increase of plasma levels of glucose, insulin, and leptin in HFD rats.
In the depth analysis, researchers found that ginger antihyperlipidemic activity was attributed to the induction of a higher liver expression of proteins associated with a variety of metabolic processes including lipid and enhanced levels of adiponectin which plays a critical role in preventing dyslipidemia.
Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of hyperlipidemia with no side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Ginger Treatment Ameliorates Alcohol-induced Myocardial Damage by Suppression of Hyperlipidemia and Cardiac Biomarkers in Rats by Subbaiah GV1, Mallikarjuna K2, Shanmugam B1, Ravi S1, Taj PU1, Reddy KS1. (PubMed)
(2) Molecular factors involved in the hypolipidemic- and insulin-sensitizing effects of a ginger (Zingiber officinale Roscoe) extract in rats fed a high-fat diet by de Las Heras N1, Valero-Muñoz M1, Martín-Fernández B1, Ballesteros S1, López-Farré A2, Ruiz-Roso B3, Lahera V1. (PubMed)
(3) A Western-Fed Diet Increases Plasma HDL and LDL-Cholesterol Levels in ApoD–/– Mice by Kamilah Ali, Ehab M. Abo-Ali, M. D. Kabir, 1 Bethany Riggins, 1 Susanna Nguy, 1Lisa Li, 1 Ujala Srivastava, 1 and Su Mya Mya Thinn. (PMC)
Wednesday, May 8, 2019
Plant-Based Alliin, the Potential Anti Ovarian Cancer Phytochemical
Ovarian cancer is a chronic and medical condition caused by cell growth irregularly in the tissue of the ovary.
Most cases of ovarian cancer begin in the cells on the surface of the inner lining tissue of the ovary before spreading to the deeper layers to form a tumor.
In the very early stage, due to the very small size of the tumor, most patients are asymptomatic. However, as the disease progression, patients may experience symptoms shared commonly with other types of cancer accompanied by specific symptoms of abdominal bloating or swelling, discomfort in the pelvis area, changes in bowel habits, such as constipation.
According to the statistics provided by the American Cancer Society, ovarian cancer ranks fifth in cancer deaths among women, accounting for more deaths than any other cancer of the female reproductive system.
A woman risk of ovarian cancer is 1 in 78. and the risk of the lifetime chance of dying from ovarian cancer is about 1 in 108.
The five-year relative survival rate for all types and stages of ovarian cancer is 47 percent, Cancer diagnosed at the early stage have a 5-year survival rate of over 72%.
The exact causes of ovarian cancer are not known. However, according to the epidemiological studies genetics preposition such as BRCA1 and BRCA2, family and history of cancer or endometriosis, aging, reproductive history, and infertility and obesity are some of the prevalent factors involved in the onset of ovarian cancer.
The Canadian Cancer Society in the evaluation of the risk of ovarian cancer in women who are never being pregnant or giving birth wrote, "Women who have never been pregnant have a higher risk of developing ovarian cancer than women who have been pregnant".
And, "Researchers think that the lower risk may be because the hormones that are present during pregnancy have a protective effect. It is possible that the higher risk in women who have never been pregnant is linked to the factors that may make it difficult for her to become pregnant".
In other words, women who have at least one pregnancy are at a lower risk of ovarian cancer compared to women who do not.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a natural and potential compound for the treatment of ovarian cancer without inducing adverse effects, researchers examined the efficacy of preparation including chemical conjugate between daidzein and the garlic enzyme alliinase.
According to the tested assays, the conjugate specifically bound to ovarian cancer cells and upon addition of the prodrug alliin by inducing the cytotoxic allicin molecules in killing the cancer cells.
In vivo, the preparation showed a targeting and antitumor effect confirmed by NIR and bioluminescence imagine in the luciferase-expression of ovarian cancer cells.
Treatment of ovarian tumor-bearing mice with daidzein-alliinase and alliin effectively attenuated tumor progression during the first 12 days.
Compared to placebo, only small individual foci of luminescence at the site of tumor cells inoculation was found in the treatment group, according to autopsy.
Interestingly, the preparation did not reveal any additional foci of carcinoma or signs of toxicity, according to the histological examination of organs and tissues.
In other words, the chemical conjugate between daidzein and the garlic enzyme alliinase induced ovarian cancer cells apoptosis through its cytotoxic effects without causing harm to the nearby healthy cells.
Based on the findings researchers wrote in the final report, "the targeted alliinase conjugates in the presence of alliin, generated therapeutically effective levels of allicin which were capable of suppressing tumor progression of intraperitoneal ovarian cancer in an animal model".
Taken altogether, alliin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of ovarian cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Conjugates of daidzein-alliinase as a targeted pro-drug enzyme system against ovarian carcinoma by Appel E1, Rabinkov A, Neeman M, Kohen F, Mirelman D. (PubMed)
(2) Risk factors for ovarian cancer by the Canadian Cancer Society
Most cases of ovarian cancer begin in the cells on the surface of the inner lining tissue of the ovary before spreading to the deeper layers to form a tumor.
In the very early stage, due to the very small size of the tumor, most patients are asymptomatic. However, as the disease progression, patients may experience symptoms shared commonly with other types of cancer accompanied by specific symptoms of abdominal bloating or swelling, discomfort in the pelvis area, changes in bowel habits, such as constipation.
According to the statistics provided by the American Cancer Society, ovarian cancer ranks fifth in cancer deaths among women, accounting for more deaths than any other cancer of the female reproductive system.
A woman risk of ovarian cancer is 1 in 78. and the risk of the lifetime chance of dying from ovarian cancer is about 1 in 108.
The five-year relative survival rate for all types and stages of ovarian cancer is 47 percent, Cancer diagnosed at the early stage have a 5-year survival rate of over 72%.
The exact causes of ovarian cancer are not known. However, according to the epidemiological studies genetics preposition such as BRCA1 and BRCA2, family and history of cancer or endometriosis, aging, reproductive history, and infertility and obesity are some of the prevalent factors involved in the onset of ovarian cancer.
The Canadian Cancer Society in the evaluation of the risk of ovarian cancer in women who are never being pregnant or giving birth wrote, "Women who have never been pregnant have a higher risk of developing ovarian cancer than women who have been pregnant".
And, "Researchers think that the lower risk may be because the hormones that are present during pregnancy have a protective effect. It is possible that the higher risk in women who have never been pregnant is linked to the factors that may make it difficult for her to become pregnant".
In other words, women who have at least one pregnancy are at a lower risk of ovarian cancer compared to women who do not.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a natural and potential compound for the treatment of ovarian cancer without inducing adverse effects, researchers examined the efficacy of preparation including chemical conjugate between daidzein and the garlic enzyme alliinase.
According to the tested assays, the conjugate specifically bound to ovarian cancer cells and upon addition of the prodrug alliin by inducing the cytotoxic allicin molecules in killing the cancer cells.
In vivo, the preparation showed a targeting and antitumor effect confirmed by NIR and bioluminescence imagine in the luciferase-expression of ovarian cancer cells.
Treatment of ovarian tumor-bearing mice with daidzein-alliinase and alliin effectively attenuated tumor progression during the first 12 days.
Compared to placebo, only small individual foci of luminescence at the site of tumor cells inoculation was found in the treatment group, according to autopsy.
Interestingly, the preparation did not reveal any additional foci of carcinoma or signs of toxicity, according to the histological examination of organs and tissues.
In other words, the chemical conjugate between daidzein and the garlic enzyme alliinase induced ovarian cancer cells apoptosis through its cytotoxic effects without causing harm to the nearby healthy cells.
Based on the findings researchers wrote in the final report, "the targeted alliinase conjugates in the presence of alliin, generated therapeutically effective levels of allicin which were capable of suppressing tumor progression of intraperitoneal ovarian cancer in an animal model".
Taken altogether, alliin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of ovarian cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Conjugates of daidzein-alliinase as a targeted pro-drug enzyme system against ovarian carcinoma by Appel E1, Rabinkov A, Neeman M, Kohen F, Mirelman D. (PubMed)
(2) Risk factors for ovarian cancer by the Canadian Cancer Society
Bromelain Found in Pineapple Suppresses the Symptoms and Onset of Osteoarthritis (OA)
Osteoarthritis is an inflammation of joints caused by the depletion of the cartilage on the ends of the bones due to the wear and tear over time.
The disease is one most common form of arthritis that affects millions of people worldwide.
According to the statistics, in the US, approximately 10% of men and 13% in women aged 60 years or older have osteoarthritis (OA).
Most common risk factors found in patients with OA are older adults, female gender, overweight and obesity, knee injury, repetitive use of joints, low bone density.
Besides pain on the joints, other most common symptoms of OA include tenderness, stiff, low flexibility, grating sensation.
Conventionally, treatment of OA is focused on managing symptoms, by reducing pain, stiffness and swelling through the use of pain killers, improving joint mobility and flexibility and maintaining a healthy weight by exercise.
Some researchers suggested that the high prevalence of OA in the US has become a burden to the health care cost and economic burden.
Dr.Bitton R, the lead scientist at the Health Plan of Nevada wrote, "approximately one-third of direct OA expenditures are allocated for medications, much of which goes toward pain-related agents. Hospitalization costs comprise nearly half of direct costs, although these expenditures are consumed by only 5% of OA patients who undergo knee or hip replacement surgery".
And, "Indirect costs for OA are also high, largely a result of work-related losses and home-care costs".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural compound for diseases associated with inflammation, researchers investigated the effects of bromelain in mild-to-moderate knee OA patients.
The randomized, single-blind, active-controlled pilot study included 40 knee OA patients randomized to receive oral bromelain (500 mg/day) or diclofenac (100 mg/day).
At week 4, both bromelain and diclofenac treated groups showed an improvement of total the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and pain subscales compared to the baseline.
According to the tested assays, bromelain and diclofenac groups exerted similar effects after 4 weeks.
At week 16 of bromelain treatment, patients had improved total WOMAC scores (12.2 versus 25.5), pain subscales (2.4 versus 5.6), stiffness subscales (0.8 versus 2.0), and function subscales (9.1 versus 17.9), and physical component of SF-36 (73.3 versus 65.4) as compared with baseline values.
In other words, bromelain reduced symptoms and improved quality of life in OA patients by inhibiting the levels of oxidative stress and overexpression of pro-inflammatory cytokines at week 16.
Based on the results, researchers after taking other factors into account wrote, "Our results show the inhibitory effect of enzyme therapy on collagen-induced arthritis in rats, as well as the efficacy of cyclosporin".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of osteoarthritis (OA), pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis by Kasemsuk T1, Saengpetch N2, Sibmooh N1, Unchern S. (PubMed)
(2) The economic burden of osteoarthritis by Bitton R. (PubMed)
The disease is one most common form of arthritis that affects millions of people worldwide.
According to the statistics, in the US, approximately 10% of men and 13% in women aged 60 years or older have osteoarthritis (OA).
Most common risk factors found in patients with OA are older adults, female gender, overweight and obesity, knee injury, repetitive use of joints, low bone density.
Besides pain on the joints, other most common symptoms of OA include tenderness, stiff, low flexibility, grating sensation.
Conventionally, treatment of OA is focused on managing symptoms, by reducing pain, stiffness and swelling through the use of pain killers, improving joint mobility and flexibility and maintaining a healthy weight by exercise.
Some researchers suggested that the high prevalence of OA in the US has become a burden to the health care cost and economic burden.
Dr.Bitton R, the lead scientist at the Health Plan of Nevada wrote, "approximately one-third of direct OA expenditures are allocated for medications, much of which goes toward pain-related agents. Hospitalization costs comprise nearly half of direct costs, although these expenditures are consumed by only 5% of OA patients who undergo knee or hip replacement surgery".
And, "Indirect costs for OA are also high, largely a result of work-related losses and home-care costs".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural compound for diseases associated with inflammation, researchers investigated the effects of bromelain in mild-to-moderate knee OA patients.
The randomized, single-blind, active-controlled pilot study included 40 knee OA patients randomized to receive oral bromelain (500 mg/day) or diclofenac (100 mg/day).
At week 4, both bromelain and diclofenac treated groups showed an improvement of total the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and pain subscales compared to the baseline.
According to the tested assays, bromelain and diclofenac groups exerted similar effects after 4 weeks.
At week 16 of bromelain treatment, patients had improved total WOMAC scores (12.2 versus 25.5), pain subscales (2.4 versus 5.6), stiffness subscales (0.8 versus 2.0), and function subscales (9.1 versus 17.9), and physical component of SF-36 (73.3 versus 65.4) as compared with baseline values.
In other words, bromelain reduced symptoms and improved quality of life in OA patients by inhibiting the levels of oxidative stress and overexpression of pro-inflammatory cytokines at week 16.
Based on the results, researchers after taking other factors into account wrote, "Our results show the inhibitory effect of enzyme therapy on collagen-induced arthritis in rats, as well as the efficacy of cyclosporin".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of osteoarthritis (OA), pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis by Kasemsuk T1, Saengpetch N2, Sibmooh N1, Unchern S. (PubMed)
(2) The economic burden of osteoarthritis by Bitton R. (PubMed)
Tuesday, May 7, 2019
Honey, The Functional and Natural Depressant
Depression is a psychological illness which affects a patient mentally, including thinking and feeling and physically such as loss of interest in physical activity.
The exact causes of depression are not identified. However, some risk factors such as genetic predisposition, personality, stress, and brain chemistry are found to associate with the onset in patients with such a condition.
There are some types of depression which can be classified as follow
1. Seasonal affective disorder (SAD) is caused by the change of weather. The mood of patients is affected by the weather and time of the year.
2. Postpartum depression is associated with the mother who can not cope with change following the birth of a child.
3. Depression with psychosis is the most severe case of depression as patients have lived in the illusion and loss of touch with reality.
4. Dysthymia, a persistent depressive disorder, also called dysthymia (dis-THIE-me-uh), is considered a chronic form of mild depression.
Most cases of depression in conventional medicine are treated with medication such as selective serotonin reuptake inhibitors (SSRIs) and antidepressants, accompanied by psychotherapy.
If you take any aforementioned medicine, please make sure that you know all the side effects for preventive measure.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the course to find a natural agent for the treatment of depression with no side effects, researchers evaluated the chemical compound chrysin found abundantly in honey against chronic unpredictable mild stress (CUMS).
The study included a 28-day oral treatment with chrysin (5 or 20mg/kg) in female mice subjected to CUMS, comparing to the effect of fluoxetine.
Before treatment of chrysin, CUMS applied for 28days induced a decrease in brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels as well as in the Na(+), K(+)-ATPase activity.
Where brain-derived neurotrophic factor (BDNF ) as a neurotransmitter modulator, plays an important role in neuronal survival and growth as well as in learning and memory.
Nerve growth factor (NGF) is a neurotrophic factor involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. Reduced levels of nerve growth factor (NGF) has been found in patients with depression.
Na + /K + -ATPase is an enzyme with a function in maintaining resting potential, affects transport, and regulates cellular volume.
Clinical evidence suggested that Na+, K+-ATPase-induced activation of intracellular signaling participates in the mechanisms underlying patients with mood disorder.
Chrysin (20mg/kg) and fluoxetine improved the BDNF and NGF levels in non-stressed mice and in CUMS treatment mice.
Injection of chrysin and fluoxetine treatments also exerted an antidepressant effect by protecting the CUMS rats against all alterations of the decreased production of antioxidant enzymes and increased oxidative stress.
Based on the findings, Dr. Filho CB, the lead scientists, "the up-regulation of BDNF and NGF levels is a mechanism possibly involved in the antidepressant effect of chrysin in mice".
Furthermore, in order to reveal more information about the honey antidepressant property, researchers examined investigated the effect of chrysin in mice exposed to unpredictable chronic stress (UCS).
In UCS applied for 28 days induced depressive-like rats, oral treatment with chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine (10mg/kg, positive control) inhibited the decrease in the time of grooming in the splash test and increase in the immobility time.
Chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine treatment was also found to inhibit the production of pro-inflammatory cytokines and elevated corticotropin-releasing hormone and adrenocorticotropic hormone in the UCS-induced depressive-like rats.
Where elevated corticotropin-releasing hormone and adrenocorticotropic hormone was associated with patients with depression.
Moreover, Chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine treatment also attenuated the hormone deficiency such as 5-HT levels in the HP and elevated enzyme and matrixes such as indoleamine-2,3-dioxygenase, caspase 3 and 9 activities in the PFC and HP associated with depression-like symptoms, induced by UCS.
Taken altogether, honey processed bioactive compound chrysin may be considered a functional remedy for the treatment of depression, pending to the confirmation of larger sample size and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin by Filho CB1, Jesse CR2, Donato F1, Giacomeli R1, Del Fabbro L1, da Silva Antunes M1, de Gomes MG1, Goes AT1, Boeira SP1, Prigol M1, Souza LC. (PubMed)
(2) Neurochemical factors associated with the antidepressant-like effect of flavonoid chrysin in chronically stressed mice by Filho CB1, Jesse CR2, Donato F1, Del Fabbro L1, de Gomes MG1, Goes ATR1, Souza LC1, Giacomeli R1, Antunes M1, Luchese C3, Roman SS4, Boeira SP. (PubMed)
The exact causes of depression are not identified. However, some risk factors such as genetic predisposition, personality, stress, and brain chemistry are found to associate with the onset in patients with such a condition.
There are some types of depression which can be classified as follow
1. Seasonal affective disorder (SAD) is caused by the change of weather. The mood of patients is affected by the weather and time of the year.
2. Postpartum depression is associated with the mother who can not cope with change following the birth of a child.
3. Depression with psychosis is the most severe case of depression as patients have lived in the illusion and loss of touch with reality.
4. Dysthymia, a persistent depressive disorder, also called dysthymia (dis-THIE-me-uh), is considered a chronic form of mild depression.
Most cases of depression in conventional medicine are treated with medication such as selective serotonin reuptake inhibitors (SSRIs) and antidepressants, accompanied by psychotherapy.
If you take any aforementioned medicine, please make sure that you know all the side effects for preventive measure.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the course to find a natural agent for the treatment of depression with no side effects, researchers evaluated the chemical compound chrysin found abundantly in honey against chronic unpredictable mild stress (CUMS).
The study included a 28-day oral treatment with chrysin (5 or 20mg/kg) in female mice subjected to CUMS, comparing to the effect of fluoxetine.
Before treatment of chrysin, CUMS applied for 28days induced a decrease in brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels as well as in the Na(+), K(+)-ATPase activity.
Where brain-derived neurotrophic factor (BDNF ) as a neurotransmitter modulator, plays an important role in neuronal survival and growth as well as in learning and memory.
Nerve growth factor (NGF) is a neurotrophic factor involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. Reduced levels of nerve growth factor (NGF) has been found in patients with depression.
Na + /K + -ATPase is an enzyme with a function in maintaining resting potential, affects transport, and regulates cellular volume.
Clinical evidence suggested that Na+, K+-ATPase-induced activation of intracellular signaling participates in the mechanisms underlying patients with mood disorder.
Chrysin (20mg/kg) and fluoxetine improved the BDNF and NGF levels in non-stressed mice and in CUMS treatment mice.
Injection of chrysin and fluoxetine treatments also exerted an antidepressant effect by protecting the CUMS rats against all alterations of the decreased production of antioxidant enzymes and increased oxidative stress.
Based on the findings, Dr. Filho CB, the lead scientists, "the up-regulation of BDNF and NGF levels is a mechanism possibly involved in the antidepressant effect of chrysin in mice".
Furthermore, in order to reveal more information about the honey antidepressant property, researchers examined investigated the effect of chrysin in mice exposed to unpredictable chronic stress (UCS).
In UCS applied for 28 days induced depressive-like rats, oral treatment with chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine (10mg/kg, positive control) inhibited the decrease in the time of grooming in the splash test and increase in the immobility time.
Chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine treatment was also found to inhibit the production of pro-inflammatory cytokines and elevated corticotropin-releasing hormone and adrenocorticotropic hormone in the UCS-induced depressive-like rats.
Where elevated corticotropin-releasing hormone and adrenocorticotropic hormone was associated with patients with depression.
Moreover, Chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine treatment also attenuated the hormone deficiency such as 5-HT levels in the HP and elevated enzyme and matrixes such as indoleamine-2,3-dioxygenase, caspase 3 and 9 activities in the PFC and HP associated with depression-like symptoms, induced by UCS.
Taken altogether, honey processed bioactive compound chrysin may be considered a functional remedy for the treatment of depression, pending to the confirmation of larger sample size and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin by Filho CB1, Jesse CR2, Donato F1, Giacomeli R1, Del Fabbro L1, da Silva Antunes M1, de Gomes MG1, Goes AT1, Boeira SP1, Prigol M1, Souza LC. (PubMed)
(2) Neurochemical factors associated with the antidepressant-like effect of flavonoid chrysin in chronically stressed mice by Filho CB1, Jesse CR2, Donato F1, Del Fabbro L1, de Gomes MG1, Goes ATR1, Souza LC1, Giacomeli R1, Antunes M1, Luchese C3, Roman SS4, Boeira SP. (PubMed)
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