Gastric cancer is a medical condition characterized by the uncontrollable growth of cells in the gastric tissues. At the late stage, the cancerous cells may infect other organs and tissue a distance away from the original site
According to medical literature published online, in vascular endothelial growth factor (VEGF) overexpression in formation of new blood vessel to provide nutrients and fluids for the survival of gastric cancer, application of green tea (-)-Epigallocatechin-3-gallate (EGCG) restricted the pro-inflammatory cytokine interleukin-6 (IL-6) induced VEGF in stimulated signal protein in transmitted alternated DNA transcript and activated suppression of anti-cell apoptosis transcription 3 (Stat3).
Oral administration of green tea extract decreased levels of IL-6, VEGF overexpression in doses depending manner.
In compared to a healthy individual, IL-6, VEGF expression was found to increase more than 2.4-fold in patients with gastric cancer.
In fact, the chemical compound exhibited anti-cancer progressive activity by blocking the process of a complex sequence of VEGF expression in transferring faulty DNA transcription to signal the proliferation of cancer cells through mRNA in protein synthesis.
In other words, green tea inhibited the progression of cancer development induced by overexpression of vascular endothelial growth factor (VEGF) was total depended on EGCG's DNA biding activity and inhibition of Stat proteins in differentiated cytoplasm into the nucleus, the important step in the initiation of cancer progression.
Further analysis, according to experiments in vitro and vitro, EGCG also expressed a significant effect in the reduced the IL-6 properties in stimulated vascular endothelial cells in promoted cancer cells proliferation and formation.
After taking into account of other confounders, Dr. Zhu BH, the lead author said, "EGCG inhibits IL-6-induced VEGF expression and angiogenesis via suppressing Stat3 activity in gastric cancer, which has provided a novel mechanistic insight into the anti-angiogenic activity of EGCG".
Additionally, researchers in further illustration of the effect of EGCG (0, 5, 10, 25 or 50 μmol/L), in human gastric cancer cells (AGS) caused by IL-6 (50 μg/L) suggested that interleukin 6 (IL-6)overexpression not only significantly increased VEGF expression in AGS gastric cancer cells, but also increased function of mRNA expression by more than 2.4 in the process to initiated tumor development, in dose depending manner.
Truly, treatment of bioactive EGCG with doses of 0, 5, 10, 25 or 50 μmol/L demonstrated therapeutic activities in reduced the released protein of VEGF to stimulated and mRNA expression of the alternated transcript.
In compared to AG490, a Stat3 pathway inhibitor used for the treatment of gastric cancer, green tea EGCG blocked the sequence of transcript transferred step in induced expression of pSTAT3 in the proliferation of cells and tumor tissues without causing a change in STAT3 gene.
In 5-FU resistance of GC SGC7901/FU and MGC803/FU, gastric cancer cell lines, injection of epigallocatechin gallate (EGCG) displayed a significantly suppressed the proliferation and tumor growth through reversed the 5-FU resistance of GC cells thorough inhibited the P-glycoprotein 1 (MDR1) and P-glycoprotein (P-gp) also also known as multidrug resistance proteins in transmitted transcript in obstructing cell internalization of chemotherapeutic agents and developing transporter-mediated resistance by cancer cells during anti-tumor treatments.
Taking all together, green tea bioactive (-)-Epigallocatechin-3-gallate (EGCG) may be considered as a potential agent in reduced risk of angiogenesis and secondary and adjunct treatment is combined with standard chemotherapy in the treatment of gastric cancers.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer by Zhu BH1, Chen HY, Zhan WH, Wang CY, Cai SR, Wang Z, Zhang CH, He YL.(PubMed)
(2) [(-)-Epigallocatechin-3-gallate reduces vascular endothelial growth factor expression in gastric cancer cells via suppressing activity].[Article in Chinese] by Zhu BH1, He YL, Zhan WH, Cai SR, Wang Z, Zhang CH, Chen HY.(PubMed)
(3) Reversal of 5-fluorouracil resistance by EGCG is mediate by inactivation of TFAP2A/VEGF signaling pathway and down-regulation of MDR-1 and P-gp expression in gastric cancer by Tang H1,2, Zeng L2, Wang J2, Zhang X2, Ruan Q2, Wang J2, Cui S2, Yang D1.(PubMed)
Thursday, August 1, 2019
Whole Food Onion Kills Renal Cancer Cells in Vitro
The kidney is an essential organ that not only filters out blood but also regulates electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin,
Formed part of the urinary system, kidney filters blood with billions of glomeruli by separating the cells of blood from plasma. During the process, some necessary substances are reabsorbed back into the blood, while others wastes, such as urea and ammonium are stored into pelvis then into the ureter to the bladder.
Kidney cancer is a medical condition caused by malignant cells of the lining of the tubules in the kidney.
At the advanced stage, cancer kidney cells can travel a distance away to infect other healthy tissue and organ through the circulation of blood and fluid, leading to secondary metastasis.
Kidney cancer epidemiologically has been found to spread to the lung.
The exact causes of kidney cancer are not identified. However, the below prevalent factors have been found to induce a higher risk of the disease.
* Gender
Men are twice at risk to develop renal cell carcinoma than women.
* Aging
The onset of renal cell carcinoma has a peak incidence in the 50 but today, the disease has a tendency to affect the younger age population.
* Smoking
Smoking increases the risk of renal cell carcinoma.
* Obesity
Obesity has been associated with an increased risk of renal cell cancer among women, and increased BMI is equally strongly associated with an increased risk of renal cell cancer among men and women.
* Family history
If one of your direct family members has it, your risk of developing renal cell carcinoma increases.
* Chemical toxins
Exposure to certain environment chemical toxins may increase the risk of renal cell carcinoma.
* Cystic kidney disease
This type of genetic disorder of the kidneys accompanied by a renal deficiency can increase the risk of developing kidney cancer.
Because of less nervous in the kidney and location, the early stage of renal cell carcinoma is very hard to detect. In some case, the tumor can grow without causing any pain and discomfort. Most common symptoms are abdominal pain, back pain, blood in the urine, flank pain, anemia, varicocele enlargement, and hypertension.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility of kidney cancer
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste, onion is found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a natural ingredient for the treatment of renal cancer, researchers examined the effects of fisetin, a natural compound found in fruits and vegetables such as strawberries, apples, cucumbers, and onions in human renal carcinoma (Caki) cells.
According to the tested assays, Fisetin induced cancer cell apoptosis by causing cell cycle arrest on the sub-G1 phase.
Futhermore, Fisetin also induced cancer cell apoptosis by activating the proteins (cleavage of poly (ADP-ribose) polymerase (PARP) associated with cell death programming.
Moreover, caspases, the major effectors of apoptosis were also activated by the injection of Fisetin.
Additionally, the efficacy of Fisetin in the inhibition of the renal cancer cell line was also attributed by inducing death receptor 5 (DR5) expression and promoting the gene expression of tumor suppressor (p53).
However, in the differentiation of the effect of another gene (CHOP expression) associated with cellular stress and involved in mediating apoptosis and expression of ROS cytotoxicity, researchers found that fisetin-induced apoptosis without the assistance of CHOP and ROS.
Based on the finding, researchers said, " fisetin induced apoptosis through p53 mediated up-regulation of DR5 expression at the transcriptional level"
Taken altogether, onion used alone or combined with remedies may be considered a remedy for the prevention and treatment of renal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells by Min KJ1, Nam JO2, Kwon TK. (PubMed)
(2) Most common Types of Cancer -Kidney Cancer (Renal Cell Carcinoma) by Kyle J. Norton
Formed part of the urinary system, kidney filters blood with billions of glomeruli by separating the cells of blood from plasma. During the process, some necessary substances are reabsorbed back into the blood, while others wastes, such as urea and ammonium are stored into pelvis then into the ureter to the bladder.
Kidney cancer is a medical condition caused by malignant cells of the lining of the tubules in the kidney.
At the advanced stage, cancer kidney cells can travel a distance away to infect other healthy tissue and organ through the circulation of blood and fluid, leading to secondary metastasis.
Kidney cancer epidemiologically has been found to spread to the lung.
The exact causes of kidney cancer are not identified. However, the below prevalent factors have been found to induce a higher risk of the disease.
* Gender
Men are twice at risk to develop renal cell carcinoma than women.
* Aging
The onset of renal cell carcinoma has a peak incidence in the 50 but today, the disease has a tendency to affect the younger age population.
* Smoking
Smoking increases the risk of renal cell carcinoma.
* Obesity
Obesity has been associated with an increased risk of renal cell cancer among women, and increased BMI is equally strongly associated with an increased risk of renal cell cancer among men and women.
* Family history
If one of your direct family members has it, your risk of developing renal cell carcinoma increases.
* Chemical toxins
Exposure to certain environment chemical toxins may increase the risk of renal cell carcinoma.
* Cystic kidney disease
This type of genetic disorder of the kidneys accompanied by a renal deficiency can increase the risk of developing kidney cancer.
Because of less nervous in the kidney and location, the early stage of renal cell carcinoma is very hard to detect. In some case, the tumor can grow without causing any pain and discomfort. Most common symptoms are abdominal pain, back pain, blood in the urine, flank pain, anemia, varicocele enlargement, and hypertension.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility of kidney cancer
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste, onion is found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a natural ingredient for the treatment of renal cancer, researchers examined the effects of fisetin, a natural compound found in fruits and vegetables such as strawberries, apples, cucumbers, and onions in human renal carcinoma (Caki) cells.
According to the tested assays, Fisetin induced cancer cell apoptosis by causing cell cycle arrest on the sub-G1 phase.
Futhermore, Fisetin also induced cancer cell apoptosis by activating the proteins (cleavage of poly (ADP-ribose) polymerase (PARP) associated with cell death programming.
Moreover, caspases, the major effectors of apoptosis were also activated by the injection of Fisetin.
Additionally, the efficacy of Fisetin in the inhibition of the renal cancer cell line was also attributed by inducing death receptor 5 (DR5) expression and promoting the gene expression of tumor suppressor (p53).
However, in the differentiation of the effect of another gene (CHOP expression) associated with cellular stress and involved in mediating apoptosis and expression of ROS cytotoxicity, researchers found that fisetin-induced apoptosis without the assistance of CHOP and ROS.
Based on the finding, researchers said, " fisetin induced apoptosis through p53 mediated up-regulation of DR5 expression at the transcriptional level"
Taken altogether, onion used alone or combined with remedies may be considered a remedy for the prevention and treatment of renal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells by Min KJ1, Nam JO2, Kwon TK. (PubMed)
(2) Most common Types of Cancer -Kidney Cancer (Renal Cell Carcinoma) by Kyle J. Norton
Wednesday, July 31, 2019
Green Tea and Bioactive Saponin In Prevention and Treatment of Lymphoma
Lymphoma is a medical condition characterized by cell growth disorderly and uncontrollably in the lymph nodes. There were 661,996 people living with non-Hodgkin lymphoma in the United States, 2014.
According to the medical literature online, intake of green tea saponin and phenolic may have a strong influence in lymphoma oncogenesis through some certain aspects.
In EL4 cancer cells line, injection of green bioactive saponin stimulated the immunomodulatory activity in inhibited EL4 cell lines through regulated cytokine expression induced by inflammation and mitogen-activated protein kinases (MAPK) signaling pathway involved in a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival.
Furthermore, injected saponin also reduced the expression of EL4 cells line in tumor proliferation by interrupting the process of sequence of mutated DNA transcript in mRNA expression in transmitting transcript by initiating production of inflammatory cytokines to reverse transcription-polymerase chain reaction in making copies of alternated gene, thus attenuating risk of tumor growth, tumor progression and immuno-suppression, activities in host anti-tumor response.
Treatment of green tea saponin also was found to induced cytotoxicity to EL4 cancer cell line without causing harm to healthy cells.
Additionally, the efficacy of tea saponin in inhibition of the proliferation and invasiveness of T-lymphoma (EL4) cells, may be also attributed to the effect of others inflammatory cytokines such as tumor necrosis factor-alpha TNF-α in induced cancer cells death and NF-κB in controlled transcription of DNA, cytokine production and cell survival through mediated the regulation of MAPK pathway in transduction (process by which foreign DNA is introduced into a cell by a virus or viral vector) and extracellular signals to cellular responses in induction of cell proliferation, differentiation, development, transformation, and apoptosis.
Tumor necrosis factor-alpha TNF-α, a pro-inflammatory cytokine plays an important role in the acute phase of inflammation with function in the regulation of biological processes including cell proliferation, differentiation, and apoptosis.
Nuclear factor-κB (NF-κB) is a transcription factor with function in the regulated expression of genes involving many biological processes including innate and adaptive immunity, inflammation and stress responses,
In NOD/SCID mice transplanted intraperitoneally with human non-Hodgkin's lymphoma (NHL) cell lines Namalwa, RAP1-EIO and HS-Sultan, injection of green tea displayed significant inhibition of
50% of Namalwa tumors and RAP1-EIO and HS-Sultan tumor through paralyzed tumor invasive activities.
In compared to chemotherapy drug cyclophosphamide, green tea exhibited anti-angiogenic effect in induction of.frequency of apoptotic endothelial and tumor cell and promoted tumor shrinking by blocking the formation of new blood vessels in providing nutrients and fluid for tumor expansion.
Base on the information findings, researchers opinionated, "Further trials in NHL to evaluate whether green tea, alone or in combination with chemotherapy, may delay or prevent disease progression".
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Immunomodulatory effect of tea saponin in immune T-cells and T-lymphoma cells via regulation of Th1, Th2 immune response and MAPK/ERK2 signaling pathway by Bhardwaj J1, Chaudhary N, Seo HJ, Kim MY, Shin TS, Kim JD.(PubMed)
(2) Inhibition of angiogenesis and induction of endothelial and tumor cell apoptosis by green tea in animal models of human high-grade non-Hodgkin's lymphoma by Bertolini F1, Fusetti L, Rabascio C, Cinieri S, Martinelli G, Pruneri G.(PubMed)
Herbal Turmeric the Natural Prevention and treatment of Cholecystitis
Cholecystitis is the most common condition caused by the gallbladder stones blockage of the cystic duct, which carries bile from the gallbladder, leading to the inflammation of the gallbladder.
Most common symptoms of cholecystitis are severe pain in your upper right or center abdomen, pain that spreads to your right shoulder or back and tenderness over your abdomen when it's touched.
Some patients may also experience symptoms of nausea, vomiting, and fever due to inflammation.
Cholecystitis can be classified into
* Acute cholecystitis is an inflammation of gallbladders that occurs within hours caused by the obstruction of the stone in the bile duct. Calculous cholecystitis is the most common, and less serious, type of acute cholecystitis. accounting 95% of all cases.
* Chronic cholecystitis is a gallbladder inflammation caused by blockage of gallstone that lasts longer than 12 weeks. Most cases of chronic cholecystitis are associated with prior episodes of acute cholecystitis.
Most common risk factors associated with chronic are cholecystitis, infection of the bile duct drainage system, bile duct blockage and excessive cholesterol in the gallbladder that facilitates the onset of gallstone, and decreased blood supply to the gallbladder due to diabetes.
Conventionally, treatment of chronic cholecystitis totally depending on the severity of the condition such as antibiotics for the infection, medicine to dissolve gallstones and pain relief and surgery.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of cholecystitis, researchers examined the effect of turmeric on cholestasis, a clinically significant symptom and widely associated with liver diseases.
Danning tablet (DNT, a Chinese patent medicine preparation) selected to the study has been clinically used to treat human liver and gallbladder diseases for more than 20 years in China, not only showed significant benefits for the treatment for patients with cholecystitis after cholecystectomy surgery, clinically but also showed protective effect against alpha-naphthylisothiocyanate (ANIT)-induced cholestasis model in rodent.
Additional differentiation of the efficacy of DNT in patients with cholecystitis, researchers found that curcumin, the major compound derived from DNT, demonstrated the protective effect against cholestasis through farnesoid X receptor (FXR), which plays a pivotal role in regulating bile acid, lipid, and glucose homeostasis.
Furthermore, curcumin also inhibited the production of pro-inflammatory cytokines that cause gallbladder inflammation by restoring the bile acid homeostasis.
In other words, curcumin protected the gallbladder against the onset of cholecystitis by inhibiting the proteins and signaling pathways in the activation of inflammation of the gallbladder tissues.
Based on the findings, researchers wrote, "Collectively, curcumin can be served as a potential treatment option for liver injury with cholestasis".
Taken altogether, turmeric processed abundantly n=bioactive compound may be used alone or combined with other remedies for the prevention and treatment of cholecystitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation by Fan Yang,1,* Xiaowen Tang,1,* Lili Ding,1 Yue zhou,1 Qiaoling Yang,1 Junting Gong,1Guangyun Wang,1 Zhengtao Wang,a,1 and Li Yang. (PMC)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)
Most common symptoms of cholecystitis are severe pain in your upper right or center abdomen, pain that spreads to your right shoulder or back and tenderness over your abdomen when it's touched.
Some patients may also experience symptoms of nausea, vomiting, and fever due to inflammation.
Cholecystitis can be classified into
* Acute cholecystitis is an inflammation of gallbladders that occurs within hours caused by the obstruction of the stone in the bile duct. Calculous cholecystitis is the most common, and less serious, type of acute cholecystitis. accounting 95% of all cases.
* Chronic cholecystitis is a gallbladder inflammation caused by blockage of gallstone that lasts longer than 12 weeks. Most cases of chronic cholecystitis are associated with prior episodes of acute cholecystitis.
Most common risk factors associated with chronic are cholecystitis, infection of the bile duct drainage system, bile duct blockage and excessive cholesterol in the gallbladder that facilitates the onset of gallstone, and decreased blood supply to the gallbladder due to diabetes.
Conventionally, treatment of chronic cholecystitis totally depending on the severity of the condition such as antibiotics for the infection, medicine to dissolve gallstones and pain relief and surgery.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of cholecystitis, researchers examined the effect of turmeric on cholestasis, a clinically significant symptom and widely associated with liver diseases.
Danning tablet (DNT, a Chinese patent medicine preparation) selected to the study has been clinically used to treat human liver and gallbladder diseases for more than 20 years in China, not only showed significant benefits for the treatment for patients with cholecystitis after cholecystectomy surgery, clinically but also showed protective effect against alpha-naphthylisothiocyanate (ANIT)-induced cholestasis model in rodent.
Additional differentiation of the efficacy of DNT in patients with cholecystitis, researchers found that curcumin, the major compound derived from DNT, demonstrated the protective effect against cholestasis through farnesoid X receptor (FXR), which plays a pivotal role in regulating bile acid, lipid, and glucose homeostasis.
Furthermore, curcumin also inhibited the production of pro-inflammatory cytokines that cause gallbladder inflammation by restoring the bile acid homeostasis.
In other words, curcumin protected the gallbladder against the onset of cholecystitis by inhibiting the proteins and signaling pathways in the activation of inflammation of the gallbladder tissues.
Based on the findings, researchers wrote, "Collectively, curcumin can be served as a potential treatment option for liver injury with cholestasis".
Taken altogether, turmeric processed abundantly n=bioactive compound may be used alone or combined with other remedies for the prevention and treatment of cholecystitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation by Fan Yang,1,* Xiaowen Tang,1,* Lili Ding,1 Yue zhou,1 Qiaoling Yang,1 Junting Gong,1Guangyun Wang,1 Zhengtao Wang,a,1 and Li Yang. (PMC)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)
Tuesday, July 30, 2019
Green Tea and Green Tea Epigallocatechin‑3-O-gallate (EGCG) In Ameliorated Risk and Treatment of Leukemia
Leukemia is a malignant progressive disease characterized by irregular cell growth in the bone marrow and other blood-forming organs. According to the statistic, approximately Over 300 children with 0-14 years of age are diagnosed with leukemia each year in Canada alone.
In the review of the literature published online, green extract epigallocatechin‑3-O-gallate (EGCG) processed a significant anti-cancer effect in reduced chronic myeloid leukemia (CML) expansion in the myeloid cells through numbers of mechanisms.
Application of green tea epigallocatechin‑3-O-gallate (EGCG) in reduced risk of chronic myeloid leukemia (CML) was found to associate to the cellular process of cyclic guanosine monophosphate (cGMP)-dependent pathway and protein kinase Cδ expression to induce cancer cells apoptosis by increased acid sphingomyelinase (ASM) and lipid raft clustering in CML cells.
Acid sphingomyelinase (ASM), an enzyme plays an important role in normal membrane turnover.
Protein kinase Cδ expression plays a key role in signal transduction and are involved in the regulation of numerous cellular processes.
Cyclic guanosine monophosphate (cGMP)-is an important second messenger in many biological processes involved a series of molecular functions.
Further analysis also suggested that exhibited sGC function by injection of green tea EGCG may be an ideal approach to suppresses proliferation and survival of human CML
In other words, reduced expression of regulation of sGC caused by decreased NO production may initiate growth and survival advantage in CML tumor cells.
Soluble guanylyl cyclase (sGC) is the only known receptor for nitric oxide.
Pharmacologically, pretreatment of soluble guanylate cyclase inhibitor NS-2028 decreased nitric oxide (NO)-stimulated sGC activity also reduced green tea polyphenol activities in activated sphingomyelinase (ASM) production.
NS-2028 is a specific inhibitor of soluble guanylyl cyclase.
In acute promyelocytic leukemia (APL), green tea (Camellia sinensis) catechin epigallocatechin-3-gallate (EGCG) displayed a strong and positive effect in elevating the expression of genes associated with cell cycle arrest and differentiation, including gene expression p27, PCAF, C/EBPα, and C/EBPɛ
P27, a cyclin-dependent kinase inhibitor 1B is an enzyme inhibitor and in elevation exerted positive regulation of cancer activity at the G1/S phase transition in cell division.
P300/CBP-associated factor (PCAF), is gene associated in binding to many sequence-specific factors involved in cell growth and/or differentiation.
Enhancer binding protein alphas/EBPα, with function in modulating the expression of genes involved in cell cycle regulation.
Enhancer binding protein epsilon (C/EBPɛ) is a protein composed of two polypeptide chains with function in binding to certain DNA regulatory regions.
Additionally, injection of EGCG also demonstrated a hugh effect against cancerous changes in gene expression and reduced expression of epigenetic modifiers DNMT1, HDAC1, HDAC2, and G9a.
DNA Methyltransferase, (DNMT1), Methylation of DNA is an important component of mammalian epigenetic gene regulation.
Histone deacetylase 1and 2 (HDAC1 and 2) are enzymes promote epigenetic repression and with function in transcriptional regulation, cell cycle progression and development.
Euchromatic histone-lysine N-methyltransferase 2 (EHMT2) or G9a.is epigenetic modifier enzymes with function in regulating gene expression involved the functional role of cancer initiation and progression. Downregulation of G9a also decreased expression of histone H3K9 (H3K9me2) is inhibited cancer cells proliferation
Other, in the multicenter case-control study conducted in China, 2008-2013, comprising 442 incident, hematologically confirmed adult leukemia cases and 442 outpatient controls, individually matched to cases by gender, birth quinquennium by the University of Western Australia also confirmed the inverse association of green tea intake to adult leukemia risk.
Risk of leukemia adjusted odds ratios of 0.50 was found in green tea drinkers in compared to nondrinker, particularly in patients with GSTM1 and GSTP1 genotypes.
Dr. Liu P, the lead author said, "regular daily green tea consumption may reduce leukemia risk in Chinese adults regardless of GSTM1 and GSTP1 polymorphic status. The association between green tea and adult leukemia risk varied with GSTT1 genotype".
Taking all together, green tea and epigallocatechin‑3-O-gallate (EGCG) intake may be considered as a secondary therapeutic application combined with standard therapy for the treatment of Leukemia regardless of polymorphic status.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells.by Huang Y1, Kumazoe M1, Bae J1, Yamada S1, Takai M1, Hidaka S1, Yamashita S1, Kim Y1, Won Y1, Murata M1, Tsukamoto S1, Tachibana H1.(PubMed)
(2) Green tea polyphenol EGCG causes anti-cancerous epigenetic modulations in acute promyelocytic leukemia cells by Borutinskaitė V1, Virkšaitė A1, Gudelytė G1, Navakauskienė R1.(PubMed)
(3) Green tea consumption and glutathione S-transferases genetic polymorphisms on the risk of adult leukemia by Liu P1, Zhang M2,3, Xie X4, Jin J5, Holman CD2.(PubMed)
Whole Food Tomato Promote the Ratio of Gut Microbiota For Optimal Health
Gut Microbiota is a community of microorganisms living in the gastrointestinal tract.
Under normal conditions, gut microbiota plays a critical role in overall health, including the impacts of
* In nutrient metabolism, gut microbiota improves the absorption of the dietary nutrients of the digestive system
* In xenobiotic and drug metabolism, gut microbiota protects the body against xenobiotics and drug toxicity through facilitating the excretion.
* Maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.
* In immunomodulation, gut microbiota interact with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
However, imbalanced of the ratio of gut microbiota may have a negative on human health and diseases.
Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".
And, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for enhancing the ratio of dut microbiota composition researchers examined the effect of consuming tomato products and lycopene on chronic inflammatory disorders associated with intestinal bacteria in an animal model.
The study included Winnie mice as a model of spontaneous ulcerative colitis treated with or without chow enriched with 1% Bronze tomato.
At week 2, the Bronze-enriched chow treated group showed no macroscopic effect on the IBD symptoms.
However, levels of pro-inflammatory cytokines found in the treated mice were significantly reduced, observed by the levels of IL17A and IFNγ.
According to the analysis of the microbial composition, two weeks of Bronze enriched diet demonstrated a strong effect in the improvement of the gut microbiota ratio in the tested mice.
Additional differentiation of the results, researchers found that the efficacy of Bronze tomato in promotion of gut health was attributed to the phytochemical polyphenols presented in the tomato.
Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplements for the gut health, pending to large sample size and multicenter human study.
Intake of polyphenols in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)
(2) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions.
Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li. (PMC)
Under normal conditions, gut microbiota plays a critical role in overall health, including the impacts of
* In nutrient metabolism, gut microbiota improves the absorption of the dietary nutrients of the digestive system
* In xenobiotic and drug metabolism, gut microbiota protects the body against xenobiotics and drug toxicity through facilitating the excretion.
* Maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.
* In immunomodulation, gut microbiota interact with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
However, imbalanced of the ratio of gut microbiota may have a negative on human health and diseases.
Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".
And, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for enhancing the ratio of dut microbiota composition researchers examined the effect of consuming tomato products and lycopene on chronic inflammatory disorders associated with intestinal bacteria in an animal model.
The study included Winnie mice as a model of spontaneous ulcerative colitis treated with or without chow enriched with 1% Bronze tomato.
At week 2, the Bronze-enriched chow treated group showed no macroscopic effect on the IBD symptoms.
However, levels of pro-inflammatory cytokines found in the treated mice were significantly reduced, observed by the levels of IL17A and IFNγ.
According to the analysis of the microbial composition, two weeks of Bronze enriched diet demonstrated a strong effect in the improvement of the gut microbiota ratio in the tested mice.
Additional differentiation of the results, researchers found that the efficacy of Bronze tomato in promotion of gut health was attributed to the phytochemical polyphenols presented in the tomato.
Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplements for the gut health, pending to large sample size and multicenter human study.
Intake of polyphenols in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)
(2) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions.
Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li. (PMC)
Monday, July 29, 2019
Green Tea and Its polyphenol (-)-epigallocatechin-3-gallate EGCG in Ameliorated Risk and Treatment of Endometrial Cancer
Endometrial cancer is a medical condition characterized by cell growth uncontrollably in the endometrium. At the late stage, the cancerous cell may travel a distance away from the original site to infect other organs and tissues.
In the review of researcher papers online, the effects of green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) in inhibition of endometrial cancer was expressed in various aspects.
In the experiment of green tea bioactive compound against the progression of tumor xenografts of human endometrial cancer, (-)-epigallocatechin-3-gallate EGCG demonstrated a significant effect in reduced risk of endometrial cancer development through the bioactive chemicals anti-tumor angiogenesis properties.
In fact, the anti-cancer active compound efficacy was attributed to the modulation of expression of vascular endothelial growth factor A (VEGFA) protein in the established new vessel to stimulate the onset of cancer and cancer cell proliferation and HIF-1 functions in activated transcription of many genes, in regulated cellular and systemic homeostatic response to external changes to tumor growth.
Furthermore, application of EGCG also suppressed responses of chemokine (C-X-C motif) ligand 12 (CXCL12) in expression of multiple physiological processes, in promoted invasion and metastasis of tumor cells in connected tissues of the uterine mucosa (endometrium), thus reducing the infiltration of VEGFA-expressing tumor-associated macrophages (TAMs) in supplying rapidly growing malignant tissues with essential nutrients and oxygen.
Additionally, further analysis also insisted that EGCG restricted secretion of vascular endothelial growth factor A (VEGFA) is initiated endometrial cancer growth by inhibiting the function of PI3K/AKT/mTOR/HIF1α pathway in regulated many cellular processes, including cell survival, proliferation, and growth.
After taking account of all findings, treatment with EGCG reduced risk of endometrial cancer onset may be results of EGCG suppressed secretion in both fronts including decreased cancer cell-secreted VEGFA but inhibited TAM-secreted VEGFA in endometrial cancer progression.
Further differentiation, also showed that green tea polyphenol (-)-epigallocatechin-3-gallate reduced cancer expansion by suppressing the expression of proliferation markers which acts indirectly to stimulate endometrial epithelial proliferation in estrogen receptor α, progesterone receptor, proliferating cell nuclear antigen and cyclin D1
The overexpression of cyclin D1 has been linked to the development and progression of cancer.
Proliferating cell nuclear antigen is a protein with function in cell cycle regulation and/or DNA replication and important for both DNA synthesis and DNA repair.
Importantly, the inhibition of EGCG also decreased the activation of ERK, the extracellular signal-regulated kinases protein in cancer cell division and down-expression of transcription factors fos and jun, the cellular immediate-early genes in induced transient cancer cell division and differentiation processes.
The function of EGCG in reduced risk of endometrial cancer also expressed through Bcl-2-associated X protein, cleavage of caspase-3 and poly(ADP-ribose) polymerase actions in induction of cancer cell apoptosis and suppression of antiapoptotic protein Bcl-2 (B-cell lymphoma 2).
Bcl-2-associated X is a protein with function of anti- or pro-apoptotic regulators involved in a wide variety of cellular activities.
B-cell lymphoma 2, a family protein with function in the regulation of cell apoptosis.
Cleavage of caspase-3 also is known as a critical executioner of apoptosis,
Poly(ADP-ribose) polymerase is a protein with function involved in a number of cellular processes, including programmed cell death.
Implicitly, application of EGCG also increased the production of free radical expression in initiated the cytotoxicity effect by reduced levels of antioxidant glutathione levels and activated the p38 in cancer cells death without inducing toxicity to normal cells
P38 mitogen-activated protein kinases (MAPKs) are activated by a wide range of cellular stresses as well as in response to inflammatory cytokines involved in cell differentiation, apoptosis, and autophagy.
Indeed, according to a systematic review of literature published on database of PubMed, Embase, Cochrane Library and China Biological Medicine Database upto February 2, 2015 , researchers indicated that green tea consumption was associated with a reduced risk of EC with a relative risk of .78 and each additional cup of green tea consumed per day decreased risk of developing EC by 11%.
Particularly, the intake of green tea associated with attenuated risk of endometrial cancer was 84.33% in compared to 5.07 % of black tea.
Taken together, green tea and its polyphenol (-)-epigallocatechin-3-gallate EGCG may be considered a functional food used conjunction with standard therapy in reduced risk and treatment of endometrial cancer.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Green tea, black tea consumption and risk of endometrial cancer: a systematic review and meta-analysis by Zhou Q1, Li H2, Zhou JG3, Ma Y4, Wu T5, Ma H6.(PubMed)
(2) A prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer by Wang J1, Man GCW2, Chan TH3, Kwong J1, Wang CC4.(PubMed)
(3) (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation by Manohar M1, Fatima I, Saxena R, Chandra V, Sankhwar PL, Dwivedi A.(PubMed)
Subscribe to:
Posts (Atom)