Gastric cancer is a medical condition characterized by the uncontrollable growth of cells in the gastric tissues. At the late stage, the cancerous cells may infect other organs and tissue a distance away from the original site
According to medical literature published online, in vascular endothelial growth factor (VEGF) overexpression in formation of new blood vessel to provide nutrients and fluids for the survival of gastric cancer, application of green tea (-)-Epigallocatechin-3-gallate (EGCG) restricted the pro-inflammatory cytokine interleukin-6 (IL-6) induced VEGF in stimulated signal protein in transmitted alternated DNA transcript and activated suppression of anti-cell apoptosis transcription 3 (Stat3).
Oral administration of green tea extract decreased levels of IL-6, VEGF overexpression in doses depending manner.
In compared to a healthy individual, IL-6, VEGF expression was found to increase more than 2.4-fold in patients with gastric cancer.
In fact, the chemical compound exhibited anti-cancer progressive activity by blocking the process of a complex sequence of VEGF expression in transferring faulty DNA transcription to signal the proliferation of cancer cells through mRNA in protein synthesis.
In other words, green tea inhibited the progression of cancer development induced by overexpression of vascular endothelial growth factor (VEGF) was total depended on EGCG's DNA biding activity and inhibition of Stat proteins in differentiated cytoplasm into the nucleus, the important step in the initiation of cancer progression.
Further analysis, according to experiments in vitro and vitro, EGCG also expressed a significant effect in the reduced the IL-6 properties in stimulated vascular endothelial cells in promoted cancer cells proliferation and formation.
After taking into account of other confounders, Dr. Zhu BH, the lead author said, "EGCG inhibits IL-6-induced VEGF expression and angiogenesis via suppressing Stat3 activity in gastric cancer, which has provided a novel mechanistic insight into the anti-angiogenic activity of EGCG".
Additionally, researchers in further illustration of the effect of EGCG (0, 5, 10, 25 or 50 μmol/L), in human gastric cancer cells (AGS) caused by IL-6 (50 μg/L) suggested that interleukin 6 (IL-6)overexpression not only significantly increased VEGF expression in AGS gastric cancer cells, but also increased function of mRNA expression by more than 2.4 in the process to initiated tumor development, in dose depending manner.
Truly, treatment of bioactive EGCG with doses of 0, 5, 10, 25 or 50 μmol/L demonstrated therapeutic activities in reduced the released protein of VEGF to stimulated and mRNA expression of the alternated transcript.
In compared to AG490, a Stat3 pathway inhibitor used for the treatment of gastric cancer, green tea EGCG blocked the sequence of transcript transferred step in induced expression of pSTAT3 in the proliferation of cells and tumor tissues without causing a change in STAT3 gene.
In 5-FU resistance of GC SGC7901/FU and MGC803/FU, gastric cancer cell lines, injection of epigallocatechin gallate (EGCG) displayed a significantly suppressed the proliferation and tumor growth through reversed the 5-FU resistance of GC cells thorough inhibited the P-glycoprotein 1 (MDR1) and P-glycoprotein (P-gp) also also known as multidrug resistance proteins in transmitted transcript in obstructing cell internalization of chemotherapeutic agents and developing transporter-mediated resistance by cancer cells during anti-tumor treatments.
Taking all together, green tea bioactive (-)-Epigallocatechin-3-gallate (EGCG) may be considered as a potential agent in reduced risk of angiogenesis and secondary and adjunct treatment is combined with standard chemotherapy in the treatment of gastric cancers.
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Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer by Zhu BH1, Chen HY, Zhan WH, Wang CY, Cai SR, Wang Z, Zhang CH, He YL.(PubMed)
(2) [(-)-Epigallocatechin-3-gallate reduces vascular endothelial growth factor expression in gastric cancer cells via suppressing activity].[Article in Chinese] by Zhu BH1, He YL, Zhan WH, Cai SR, Wang Z, Zhang CH, Chen HY.(PubMed)
(3) Reversal of 5-fluorouracil resistance by EGCG is mediate by inactivation of TFAP2A/VEGF signaling pathway and down-regulation of MDR-1 and P-gp expression in gastric cancer by Tang H1,2, Zeng L2, Wang J2, Zhang X2, Ruan Q2, Wang J2, Cui S2, Yang D1.(PubMed)
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