Psoriasis is an autoimmune disease caused by speeding up the life cycle of skin cells that lead to patches of abnormal skin.
Psoriasis may be localized which causes red, dry, itchy, and scaly skin patches in the affected area.
In cases of severity, psoriasis can cover the body completely.
Some patients also experience symptoms of thickened, pitted or ridged nails and swollen and stiff joints.
If you experience some of the aforementioned symptoms, please check with your doctor for preventive measure.
The causes of psoriasis are not identified, however, researchers believed that genetic proposition exacerbated by certain factors such as weather, injury, illness, or stress are some of the most causable factors that induce the onset of the condition.
Other risk factors associated with psoriasis may include skin injury that did not heal properly, people who are obese and side effects of long term use of certain medicines such as oral steroids.
Some researchers suggested smoking that has a strong impact on the immune system may also be one of the major causes of psoriasis in smokers.
Dr. wrote, "A number of inflammatory immune-related conditions have been associated with smoking, including psoriasis. Smoking affects the onset of psoriasis".
And, " Several pathophysiological mechanisms may explain the association of psoriasis with smoking, including oxidative stress, interaction with signaling pathways active in psoriasis, and vascular influences".
The findings strongly suggested, if you smoke, you are at a higher risk of psoriasis
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find a natural and therapeutic ingredient for the treatment of psoriasis, researchers
a cosmeceutical formulation based on boswellic acids and Vaccinium myrtillus seed oil in patients with psoriasis.
The double-blind study is to compare a novel BA formulation (containing Bosexil(®), INCI [International Nomenclature of Cosmetic Ingredients]: lecithin, Boswellia serrata resin extract) with a placebo formulation and a formulation of Vaccinium myrtillus (Bilberry) seed oil.
More precisely, patients with psoriasis or erythematous eczema were randomly assigned, in a 1:1:1 ratio, to Bosexil(®), V. myrtillus seed oil, or placebo.
During the experiment, Bosexil(®) and the V. myrtillus seed oil treatment significantly improved psoriasis, scales in comparison with placebo.
Formulation of Vaccinium myrtillus seed oil exerted a similar effect as those of Bosexil(®) without any case of worsening compared to placebo.
Furthermore, V. myrtillus seed oil improved itch and erythema in 66.7% and 77.8% of patients, respectively compared to the Bosexil(®) formulation of (60% of cases) and erythema (60% of cases) without any case of worsening, respectively.
The results clearly suggested that V. myrtillus seed oil and Bosexil(®) formulation process a strong anti-psoriasis activity without side effects.
Taken altogether, bilberry may be considered a functioning remedy for the treatment of psoriasis, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis by Togni S1, Maramaldi G1, Di Pierro F2, Biondi M. (PubMed)
(2) Psoriasis and smoking: links and risks by Luigi Naldi. (PMC)
Wednesday, September 11, 2019
Green Tea in Ameliorated Risk and Prevented Onset of Intestinal Ischemia
Green tea may have a therapeutic and positive effect in reduced risk and treatment of intestinal ischemia, some scientists suggested.
Intestinal ischemia is a serious medical condition characterized by reduced blood flow to the
intestines.
In the evaluated 3 groups of male rats randomly assigned to Group I (ischemia-reperfusion, I/R) underwent I/R of the intestine (30 min of ischemia followed by 1 h of reperfusion). Group II (green tea + I/R) was given green tea for 2 wk before inducing I/R. Group III (control) with sham I/R, researchers found that injection of green tea group showed an impressive restoration of intestinal mucosa in compared to ischemia-reperfusion (I/R) group.
In observation of cellular antioxidant profile (superoxide dismutase and catalase), green tea group expressed a significant improvement of antioxidants similar to those of group III and in compared to group II.
The expressions of cellular proliferation markers (proliferating cell nuclear antigen and Ki-67) in regulated intestinal cell division and proliferation were also increased by green tea application.
The above illustration indicated that long term intake of green tea injection may exhibit strong protection against the intestinal mucosa from injury.
Further differentiation of the effect of Quercetin, the bioactive substance of tea against experimental ischemia-reperfusion (IR) injury of the small intestine in rats, found that quercetin administrated intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following reperfusion periods lasting 1, 4 and 24h significant decreases cyclooxygenase-2 (COX-2) enzyme in the epithelial lining of the intestinal villi in expression of normal cell apoptosis only during 24h of reperfusion in a late phase of IR injury in comparison with the control group.
According to the observation of the morphology of COX-2 positive cells, COX-2 positivity was found particularly in goblet cells with function in secreted the main component of mucus.of the intestinal villi epithelium and enteroendocrine cells found in the wall of the gut that secrete hormones that regulate glucose levels, food intake, and stomach emptying respectively, in the glandular epithelium in the group I mice in compared to significantly lesser levels in green tea group.
Dr. Tóth Š, the lead authors at the joint study said," quercetin application attenuated mucosal damage from IR injury by inhibiting neutrophil infiltration which was demonstrated by a lower number of myeloperoxidase positive cells in the lamina propria".
In another similar study with male-specific pathogen-free (SPF) Charles River Wistar rats were used in the experiment with quercetin administered intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following 24h lasting reperfusion period., researchers at the joint study lead by the Pavol Jozef Safarik University, also indicated that application of quercetin increases the production of anti-inflammatory cytokine IL10 observed by analysis of the blood sample and jejunal tissue and in the number of CD68-positive cells in the lamina propria mucosae (p<0.001) in initiation of production of new blood vessels growth and inflammatory cytokines in compared to control group.
Dr. Curgali K, the lead authors, after taking into account of other con-founders, said, "the preventive application of quercetin before induction of jejunal IRI stimulates faster jejunal mucosa restoration and it seems to have immunomodulatory and anti-inflammatory effects" and "CD68-positive macrophages could have crucial role in this process since they work as both growth factor and cytokine producers".
Taken together, green tea with abundant bioactive phytochemicals such as quercetin may be considered as a functional food in reduced risk and prevented the onset of intestinal ischemia. People with high risk in the development of intestinal ischemia may consider adding 1 or 2 cups of green tea into their daily diet.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of green tea on intestinal ischemia-reperfusion injury by Abdeen SM1, Mathew TC, Dashti HM, Asfar S.(PubMed)
(2) Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa by Tóth Š1, Jonecová Z1, Čurgali K1, Maretta M2, Šoltés J1, Švaňa M1, Kalpadikis T1, Caprnda M3, Adamek M4, Rodrigo L5, Kruzliak P6.(PubMed)
(3) Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells by Curgali K1, Toth S1, Jonecova Z1, Maretta M2, Kalpakidis T1, Petriskova I1, Kusnier M1, Soltes J1, Svana M1, Caprnda M3, Delev D4, Rodrigo L5, Mechirova E1, Kruzliak P6.(PubMed)
Intestinal ischemia is a serious medical condition characterized by reduced blood flow to the
intestines.
In the evaluated 3 groups of male rats randomly assigned to Group I (ischemia-reperfusion, I/R) underwent I/R of the intestine (30 min of ischemia followed by 1 h of reperfusion). Group II (green tea + I/R) was given green tea for 2 wk before inducing I/R. Group III (control) with sham I/R, researchers found that injection of green tea group showed an impressive restoration of intestinal mucosa in compared to ischemia-reperfusion (I/R) group.
In observation of cellular antioxidant profile (superoxide dismutase and catalase), green tea group expressed a significant improvement of antioxidants similar to those of group III and in compared to group II.
The expressions of cellular proliferation markers (proliferating cell nuclear antigen and Ki-67) in regulated intestinal cell division and proliferation were also increased by green tea application.
The above illustration indicated that long term intake of green tea injection may exhibit strong protection against the intestinal mucosa from injury.
Further differentiation of the effect of Quercetin, the bioactive substance of tea against experimental ischemia-reperfusion (IR) injury of the small intestine in rats, found that quercetin administrated intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following reperfusion periods lasting 1, 4 and 24h significant decreases cyclooxygenase-2 (COX-2) enzyme in the epithelial lining of the intestinal villi in expression of normal cell apoptosis only during 24h of reperfusion in a late phase of IR injury in comparison with the control group.
According to the observation of the morphology of COX-2 positive cells, COX-2 positivity was found particularly in goblet cells with function in secreted the main component of mucus.of the intestinal villi epithelium and enteroendocrine cells found in the wall of the gut that secrete hormones that regulate glucose levels, food intake, and stomach emptying respectively, in the glandular epithelium in the group I mice in compared to significantly lesser levels in green tea group.
Dr. Tóth Š, the lead authors at the joint study said," quercetin application attenuated mucosal damage from IR injury by inhibiting neutrophil infiltration which was demonstrated by a lower number of myeloperoxidase positive cells in the lamina propria".
In another similar study with male-specific pathogen-free (SPF) Charles River Wistar rats were used in the experiment with quercetin administered intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following 24h lasting reperfusion period., researchers at the joint study lead by the Pavol Jozef Safarik University, also indicated that application of quercetin increases the production of anti-inflammatory cytokine IL10 observed by analysis of the blood sample and jejunal tissue and in the number of CD68-positive cells in the lamina propria mucosae (p<0.001) in initiation of production of new blood vessels growth and inflammatory cytokines in compared to control group.
Dr. Curgali K, the lead authors, after taking into account of other con-founders, said, "the preventive application of quercetin before induction of jejunal IRI stimulates faster jejunal mucosa restoration and it seems to have immunomodulatory and anti-inflammatory effects" and "CD68-positive macrophages could have crucial role in this process since they work as both growth factor and cytokine producers".
Taken together, green tea with abundant bioactive phytochemicals such as quercetin may be considered as a functional food in reduced risk and prevented the onset of intestinal ischemia. People with high risk in the development of intestinal ischemia may consider adding 1 or 2 cups of green tea into their daily diet.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of green tea on intestinal ischemia-reperfusion injury by Abdeen SM1, Mathew TC, Dashti HM, Asfar S.(PubMed)
(2) Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa by Tóth Š1, Jonecová Z1, Čurgali K1, Maretta M2, Šoltés J1, Švaňa M1, Kalpadikis T1, Caprnda M3, Adamek M4, Rodrigo L5, Kruzliak P6.(PubMed)
(3) Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells by Curgali K1, Toth S1, Jonecova Z1, Maretta M2, Kalpakidis T1, Petriskova I1, Kusnier M1, Soltes J1, Svana M1, Caprnda M3, Delev D4, Rodrigo L5, Mechirova E1, Kruzliak P6.(PubMed)
Tuesday, September 10, 2019
Green Tea and Its Bioactive Polyphenols EGCG in Reduced Risk and Treatment of Hepatitis C
Green tea may have a therapeutic and positive effect in reduced risk and treatment of hepatitis C, some scientists suggested.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Hepatitis C is a medical condition induced by contaminated food intake containing hepatitis C virus (HCV). Hepatitis C has been found to associate with severe liver damage.
According to statistic, approximately 130–150 million people around the world are living with chronic HCV.
Green tea bioactive polyphenols Epigallocatechin-3-gallate (EGCG) in reduced risk and treatment of hepatitis was found to associate numbers of implications through various aspects.
In Huh7.5.1 cells, a HCV cell culture (HCVcc) system using a JFH1-GFP chimeric virus, application of green tea EGCG with 50 % effective concentration (EC(50)) of 17.9 μM demonstrated a strong effect in interrupted HCV progression through monitoring HCV RNA and protein levels in Huh7.5.1 cells infected with the JFH1 virus by preventing the mRNA in transferring infectious cell transcription in facilitated cell proliferation and division.
Importantly, injection of green tea at dose of 50 and 25 μM EGCG, expressed a significant inhibition of the presence of HCV after 2 and 5 passages in HCV cell culture (HCVcc) experiment, using an American Type Culture Collection (ATCC) reference strain, with little effect to the viral internal ribosome entry site (IRES) in initiated substitution of RNA sequences for viral protein synthesis in shutting off classic host translation to evade host immune response.
Notably, in comparison to the effect of green tea with potent anti-HCV activity
medicine, cyclosporin A and tamoxifen, researchers indicated that application of green tea showed a strong anti HCV viral activity, similarly to those of anti-hepatitis medicine through its antioxidant expression of flavonoids epigallocatechin gallate (EGCG) and 7,8-benzoflavone (α-naphthoflavone), observed in HCV cell culture (HCVcc) by blocking the entry point of the virus in initiated infection to host cells and stimulating the viral cell cycle arrest at the late stage of HCV life cycle, respectively
Interestingly, some researchers in the evaluation of green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) in hepatitis C infection suggested that EGCG processed anti-viral expression through interrupting the cross-link between HCV life cycle involving steps of entry, replication.
Injection of a concentration of 50 μM of EGCG was found to inhibit HCV infectivity by more than 90% at an early step of the viral life cycle.
Indeed, the interrupted property in blocking the HCV entry cycle to induce infection to the host cell was confirmed with HCV pseudo particles, an experiment model system in expression of cellular attachment which is the essential component of the HCV entry process.
Moreover, green tea EGCG also prevented attachment off of the virus to the cell surface in ameliorated HCV infection to the host cell without effecting viral replication and virion secretion outside of the host.
Taken together, green tea and its bioactive polyphenols EGCG may be considered as a functional food in reduced risk and combined with other standard medicine for the treatment of hepatitis C virus in the induction of acute and chronic liver diseases.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry by Calland N1, Albecka A, Belouzard S, Wychowski C, Duverlie G, Descamps V, Hober D, Dubuisson J, Rouillé Y, Séron K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate inhibits the replication cycle of hepatitis C virus by Chen C1, Qiu H, Gong J, Liu Q, Xiao H, Chen XW, Sun BL, Yang RG.(PubMed)
(3) A cell-based, microplate colorimetric screen identifies 7,8-benzoflavone and green tea gallate catechins as inhibitors of the hepatitis C virus by Fukazawa H1, Suzuki T, Wakita T, Murakami Y.(PubMed)
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Hepatitis C is a medical condition induced by contaminated food intake containing hepatitis C virus (HCV). Hepatitis C has been found to associate with severe liver damage.
According to statistic, approximately 130–150 million people around the world are living with chronic HCV.
Green tea bioactive polyphenols Epigallocatechin-3-gallate (EGCG) in reduced risk and treatment of hepatitis was found to associate numbers of implications through various aspects.
In Huh7.5.1 cells, a HCV cell culture (HCVcc) system using a JFH1-GFP chimeric virus, application of green tea EGCG with 50 % effective concentration (EC(50)) of 17.9 μM demonstrated a strong effect in interrupted HCV progression through monitoring HCV RNA and protein levels in Huh7.5.1 cells infected with the JFH1 virus by preventing the mRNA in transferring infectious cell transcription in facilitated cell proliferation and division.
Importantly, injection of green tea at dose of 50 and 25 μM EGCG, expressed a significant inhibition of the presence of HCV after 2 and 5 passages in HCV cell culture (HCVcc) experiment, using an American Type Culture Collection (ATCC) reference strain, with little effect to the viral internal ribosome entry site (IRES) in initiated substitution of RNA sequences for viral protein synthesis in shutting off classic host translation to evade host immune response.
Notably, in comparison to the effect of green tea with potent anti-HCV activity
medicine, cyclosporin A and tamoxifen, researchers indicated that application of green tea showed a strong anti HCV viral activity, similarly to those of anti-hepatitis medicine through its antioxidant expression of flavonoids epigallocatechin gallate (EGCG) and 7,8-benzoflavone (α-naphthoflavone), observed in HCV cell culture (HCVcc) by blocking the entry point of the virus in initiated infection to host cells and stimulating the viral cell cycle arrest at the late stage of HCV life cycle, respectively
Interestingly, some researchers in the evaluation of green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) in hepatitis C infection suggested that EGCG processed anti-viral expression through interrupting the cross-link between HCV life cycle involving steps of entry, replication.
Injection of a concentration of 50 μM of EGCG was found to inhibit HCV infectivity by more than 90% at an early step of the viral life cycle.
Indeed, the interrupted property in blocking the HCV entry cycle to induce infection to the host cell was confirmed with HCV pseudo particles, an experiment model system in expression of cellular attachment which is the essential component of the HCV entry process.
Moreover, green tea EGCG also prevented attachment off of the virus to the cell surface in ameliorated HCV infection to the host cell without effecting viral replication and virion secretion outside of the host.
Taken together, green tea and its bioactive polyphenols EGCG may be considered as a functional food in reduced risk and combined with other standard medicine for the treatment of hepatitis C virus in the induction of acute and chronic liver diseases.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry by Calland N1, Albecka A, Belouzard S, Wychowski C, Duverlie G, Descamps V, Hober D, Dubuisson J, Rouillé Y, Séron K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate inhibits the replication cycle of hepatitis C virus by Chen C1, Qiu H, Gong J, Liu Q, Xiao H, Chen XW, Sun BL, Yang RG.(PubMed)
(3) A cell-based, microplate colorimetric screen identifies 7,8-benzoflavone and green tea gallate catechins as inhibitors of the hepatitis C virus by Fukazawa H1, Suzuki T, Wakita T, Murakami Y.(PubMed)
Healthy Food Tomato Protects The Integrity of Neurons Against Neurological Disorders in Vivo
Neurological disorders are class of diseases associated with the brain, the spinal cord including the nerves that connect them.
Most common diseases of neurological disorders are dementia, including ALS. PD, Alzheimer's disease, birth defects of the brain and spinal cord, brain injury and tumor.
Back pain associated with the related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.
There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, and nutrition-related disease, environment, and physical injuries have been found to some major prevalent factors that induce the onset of neurological abnormalities.
Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen on post-stroke patients, difficulty reading and writing and poor cognitive abilities such as patients with dementia.
According to the American Addiction Center, if you experience some of the below symptoms persistently, inclduing headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural ingredient for the treatment of neurological inflammatory disease, researchers examined phytochemical lycopene isolated from tomatoes against experimental Parkinson's disease (PD).
The study included PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oral administration of different doses (5, 10 and 20 mg/kg/day).
All doses showed a strong effect in protecting MPTP induced depletion of striatal dopamine (DA) and its metabolites in a dose-dependent manner.
Application of all doses also attenuated MPTP-induced oxidative stress and motor abnormalities in mice treated with MPTP.
Furthermore, according to the western blot assay, lycopene protected the neurons against MPTP induced apoptosis through its antioxidant and antiapoptotic properties.
In other words, lycopene in different doses exerted a PD protective activity by restoring the neurochemicals, neuron apoptosis caused by overexpression of free radicals.
Based on the findings, researchers said, " lycopene reverses neurochemical deficits, oxidative stress, apoptosis and physiological abnormalities in PD mice and offers promise strategy in the treatment of this neurodegenerative disease".
Moreover, in Alzheimer's disease (AD), associated with neuroinflammation characterized by glial activation and release of proinflammatory mediators, researchers examined the efficacy of lycopene against β-Amyloid1-42 (Aβ1-42)-induced learning and memory impairment in an animal model.
In selected induced Aβ1-42 bilaterally followed by treatment with lycopene or rivastigmine for 14 days, lycopene remediated Aβ-induced learning and memory deficits in a dose-dependent manner.
Additionally, lycopene treated group showed to ameliorate the side effects of Aβ1-42-induced mitochondrial dysfunction along with a surge of proinflammatory cytokines (TNF-α, TGF-β, and IL-1β) and protein associated with inflammatory signaling and neuron apoptosis.
Dr. Sachdeva AK, the lead scientist after taking other factors into account, wrote, "The amelioration of Aβ1-42-induced spatial learning and memory impairment by lycopene could be linked, at least in part, to the inhibition of NF-κB activity and the down-regulation of expression of neuroinflammatory cytokines, suggesting that lycopene may be a potential candidate for AD treatment".
Taken altogether, tomatoes processed abundantly bioactive ingredient lycopene may be considered supplements for the prevention and treatment of angiotensin caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective effect of lycopene against MPTP induced experimental Parkinson's disease in mice by Prema A1, Janakiraman U1, Manivasagam T2, Thenmozhi AJ. (PubMed)
(2) Lycopene abrogates Aβ(1-42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer's disease by Sachdeva AK1, Chopra K. (PubMed)
(3) Neurological Problem Symptoms, Causes, and Effects by the American Addiction Center
Most common diseases of neurological disorders are dementia, including ALS. PD, Alzheimer's disease, birth defects of the brain and spinal cord, brain injury and tumor.
Back pain associated with the related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.
There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, and nutrition-related disease, environment, and physical injuries have been found to some major prevalent factors that induce the onset of neurological abnormalities.
Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen on post-stroke patients, difficulty reading and writing and poor cognitive abilities such as patients with dementia.
According to the American Addiction Center, if you experience some of the below symptoms persistently, inclduing headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural ingredient for the treatment of neurological inflammatory disease, researchers examined phytochemical lycopene isolated from tomatoes against experimental Parkinson's disease (PD).
The study included PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oral administration of different doses (5, 10 and 20 mg/kg/day).
All doses showed a strong effect in protecting MPTP induced depletion of striatal dopamine (DA) and its metabolites in a dose-dependent manner.
Application of all doses also attenuated MPTP-induced oxidative stress and motor abnormalities in mice treated with MPTP.
Furthermore, according to the western blot assay, lycopene protected the neurons against MPTP induced apoptosis through its antioxidant and antiapoptotic properties.
In other words, lycopene in different doses exerted a PD protective activity by restoring the neurochemicals, neuron apoptosis caused by overexpression of free radicals.
Based on the findings, researchers said, " lycopene reverses neurochemical deficits, oxidative stress, apoptosis and physiological abnormalities in PD mice and offers promise strategy in the treatment of this neurodegenerative disease".
Moreover, in Alzheimer's disease (AD), associated with neuroinflammation characterized by glial activation and release of proinflammatory mediators, researchers examined the efficacy of lycopene against β-Amyloid1-42 (Aβ1-42)-induced learning and memory impairment in an animal model.
In selected induced Aβ1-42 bilaterally followed by treatment with lycopene or rivastigmine for 14 days, lycopene remediated Aβ-induced learning and memory deficits in a dose-dependent manner.
Additionally, lycopene treated group showed to ameliorate the side effects of Aβ1-42-induced mitochondrial dysfunction along with a surge of proinflammatory cytokines (TNF-α, TGF-β, and IL-1β) and protein associated with inflammatory signaling and neuron apoptosis.
Dr. Sachdeva AK, the lead scientist after taking other factors into account, wrote, "The amelioration of Aβ1-42-induced spatial learning and memory impairment by lycopene could be linked, at least in part, to the inhibition of NF-κB activity and the down-regulation of expression of neuroinflammatory cytokines, suggesting that lycopene may be a potential candidate for AD treatment".
Taken altogether, tomatoes processed abundantly bioactive ingredient lycopene may be considered supplements for the prevention and treatment of angiotensin caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective effect of lycopene against MPTP induced experimental Parkinson's disease in mice by Prema A1, Janakiraman U1, Manivasagam T2, Thenmozhi AJ. (PubMed)
(2) Lycopene abrogates Aβ(1-42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer's disease by Sachdeva AK1, Chopra K. (PubMed)
(3) Neurological Problem Symptoms, Causes, and Effects by the American Addiction Center
Monday, September 9, 2019
Phytochemical Carotenoids Protects the Eyes of Elderly Against Age-Related Macular Degeneration
Age-related macular degeneration is a condition caused by the deterioration of the small central portion of the retina, known as the macula
Macular degeneration happened mostly in adults over 60, is one of the major cause of vision loss.
The exact causes of macular degeneration are not identified. As of today, researchers cannot explain why some elderly are susceptible to macular degeneration while others do not.
However, researchers do know that certain risk factors have been found epidemiologically to induce the risk of macular degeneration including aging, the disease has been found most commonly in people over 50, family history and genetics, race, macular degeneration is more common in Caucasians.
Smoking, obesity and medical condition such as cardiovascular disease are also associated with a higher risk of macular degeneration
There are 2 forms of macular degeneration found in the elderly
* The dry form is caused by the presence of yellow deposits, called drusen under the retina, in the macula. However, the elderly with increased was not at a higher risk of macular degeneration.
* The wet form is caused by the growth of abnormal blood vessels from the choroid, the vascular layer of the eye, underneath the retina.
Compared to the loss of vision of 10% of patients induced by the wet form, most patients of macular degeneration have the dry form which has been found to cause loss of some central vision.
Some researchers suggested that macular degeneration may also be caused by an unhealthy diet. Dr. Martha P. Montgomery wrote, "A 97-item Block food frequency questionnaire was used to gather diet information, and overall diet quality was measured using the Healthy Eating Index (HEI) and Alternate Healthy Eating Index (AHEI)".
And, "Participants in the highest quartile of diet quality had significantly reduced odds of AMD according to the AHEI score (0.54, 95% confidence interval 0.30 – 0.99) and non-significantly reduced odds of AMD according to the HEI (0.75, 0.41 – 1.38). Odds of AMD were also 51% lower in the highest quartile of fish intake compared to the lowest quartile (odds ratio = 0.49, 0.26 – 0.90)".
These results strongly suggested the risk of AMD is many folds higher in people who follow the Western diet compared to those who follow the Oriental diet.
Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
On finding a potential ingredient for the treatment of age-related macular degeneration (AMD), researchers examined the beneficial role for carotenoids in the prevention of AMD.
Epidemiologically, in a case-control study by comparing the risk AMD in subjects with late AMD, exudative AMD, and retinal pigment abnormalities with the presence of drusen, and an equal number of control subjects,
*Administration of lutein and zeaxanthin induced serum concentrations were not associated with the risk of AMD.
* Consumption of food sources of lutein and zeaxanthin (carotenoids) was associated with reducing the risk of macular degeneration.
* People with higher levels of lutein and zeaxanthin in the blood have a lower risk of AMD.
However, the reduced risk of lutein and zeaxanthin for AMD when levels of the carotenoids are elevated in the serum or diet was not consistent.
Based on the findings, researchers wrote, "Until scientifically sound knowledge is available we recommend for patients judged to be at risk for AMD to alter their diet to more dark green leafy vegetables, wear UV protective lenses and a hat when outdoors".
Taken altogether, carotenoids, particularly lutein and zeaxanthin may be considered a remedy for the prevention and treatment of age-related macular degeneration, pending to the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
Sources
(1) The role of the carotenoids, lutein, and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence by Maneli Mozaffarieh,1 Stefan Sacu,1 and Andreas Wedrich. (PMC)
(2) Overall diet quality and age-related macular degeneration by Martha P. Montgomery, M.H.S., Freya Kamel, Ph.D., M.P.H., Margaret A. Pericak-Vance, Ph.D., Jonathan L. Haines, Ph.D., Eric A. Postel, M.D., Anita Agarwal, M.D., Marie Richards, Ph.D., William K. Scott, Ph.D.,* and Silke Schmidt, Ph.D. (PMC)
Macular degeneration happened mostly in adults over 60, is one of the major cause of vision loss.
The exact causes of macular degeneration are not identified. As of today, researchers cannot explain why some elderly are susceptible to macular degeneration while others do not.
However, researchers do know that certain risk factors have been found epidemiologically to induce the risk of macular degeneration including aging, the disease has been found most commonly in people over 50, family history and genetics, race, macular degeneration is more common in Caucasians.
Smoking, obesity and medical condition such as cardiovascular disease are also associated with a higher risk of macular degeneration
There are 2 forms of macular degeneration found in the elderly
* The dry form is caused by the presence of yellow deposits, called drusen under the retina, in the macula. However, the elderly with increased was not at a higher risk of macular degeneration.
* The wet form is caused by the growth of abnormal blood vessels from the choroid, the vascular layer of the eye, underneath the retina.
Compared to the loss of vision of 10% of patients induced by the wet form, most patients of macular degeneration have the dry form which has been found to cause loss of some central vision.
Some researchers suggested that macular degeneration may also be caused by an unhealthy diet. Dr. Martha P. Montgomery wrote, "A 97-item Block food frequency questionnaire was used to gather diet information, and overall diet quality was measured using the Healthy Eating Index (HEI) and Alternate Healthy Eating Index (AHEI)".
And, "Participants in the highest quartile of diet quality had significantly reduced odds of AMD according to the AHEI score (0.54, 95% confidence interval 0.30 – 0.99) and non-significantly reduced odds of AMD according to the HEI (0.75, 0.41 – 1.38). Odds of AMD were also 51% lower in the highest quartile of fish intake compared to the lowest quartile (odds ratio = 0.49, 0.26 – 0.90)".
These results strongly suggested the risk of AMD is many folds higher in people who follow the Western diet compared to those who follow the Oriental diet.
Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
On finding a potential ingredient for the treatment of age-related macular degeneration (AMD), researchers examined the beneficial role for carotenoids in the prevention of AMD.
Epidemiologically, in a case-control study by comparing the risk AMD in subjects with late AMD, exudative AMD, and retinal pigment abnormalities with the presence of drusen, and an equal number of control subjects,
*Administration of lutein and zeaxanthin induced serum concentrations were not associated with the risk of AMD.
* Consumption of food sources of lutein and zeaxanthin (carotenoids) was associated with reducing the risk of macular degeneration.
* People with higher levels of lutein and zeaxanthin in the blood have a lower risk of AMD.
However, the reduced risk of lutein and zeaxanthin for AMD when levels of the carotenoids are elevated in the serum or diet was not consistent.
Based on the findings, researchers wrote, "Until scientifically sound knowledge is available we recommend for patients judged to be at risk for AMD to alter their diet to more dark green leafy vegetables, wear UV protective lenses and a hat when outdoors".
Taken altogether, carotenoids, particularly lutein and zeaxanthin may be considered a remedy for the prevention and treatment of age-related macular degeneration, pending to the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
Sources
(1) The role of the carotenoids, lutein, and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence by Maneli Mozaffarieh,1 Stefan Sacu,1 and Andreas Wedrich. (PMC)
(2) Overall diet quality and age-related macular degeneration by Martha P. Montgomery, M.H.S., Freya Kamel, Ph.D., M.P.H., Margaret A. Pericak-Vance, Ph.D., Jonathan L. Haines, Ph.D., Eric A. Postel, M.D., Anita Agarwal, M.D., Marie Richards, Ph.D., William K. Scott, Ph.D.,* and Silke Schmidt, Ph.D. (PMC)
Bilberry Protects the Stomach Against Gastric Ulcer, Studies Say
Gastric, stomach ulcer is an oval sore found on the lining of the stomach.
A gastric ulcer is one of the most common types of peptic ulcer disease which affects both the stomach and small intestines.
According to the epidemiological studies, gastric ulcer is caused either by the infection of bacterium Helicobacter pylori (H. pylori) or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin.
Most common symptoms are burning sensation or pain in the stomach. Most patients with gastric ulcer have pain that intensifies on empty stomach, depending on the severity of the condition.
Some patients with gastric ulcer also experience persistent dull pain in the stomach, unintended weight loss, nausea or vomiting and bloating and acid reflux.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility of a gastric ulcer.
Conventionally, most cases of gastric ulcer can be treated successfully depending on the cause, including medicine or surgery if the medicine failed.
Out of many risk factors that cause a gastric ulcer, some researchers suggested there is a correlation between obesity and gastritis as well as gastric ulcers.
Dr. Nadia B. Pietrzykowska said, "Excess body weight has been linked to various abdominal ailments. These may include abdominal pain, bloating, vomiting, heartburn, diarrhea or constipation".
And, "Scientific studies are also increasingly reporting a correlation between obesity and gastritis as well as gastric ulcers. A recent, large study that specifically focused on analyzing gastric and duodenal ulcers confirmed that excess weight predisposed individuals to gastric ulcers when compared to their normal-weight counterparts".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the testing of the effect of Vaccinium myrtillus L. anthocyanoside (VMA) used as a folk medicine to treat diseases related to gastric ulcers in northern Europe, researchers investigated the protective effects of VMA on gastric mucosal damage in a murine gastric ulcer model.
During the experiment, oral administration of VMA (10, 30 and 100 mg/kg) significantly protected gastric mucosa against HCl/ethanol-induced gastric ulcers.
VMA protected the stomach by inhibiting lipid peroxide levels in a concentration-dependent manner and exhibiting the high scavenging activity against the superoxide anion radical (·O(2) (-) ) and the hydroxyl radical (·OH).
The antioxidant activity in VMA was found to be attributed by the presence of anthocyanidins and delphinidin.
Based on the findings, Dr. Ogawa K, the lead scientist said, "These findings indicate that the protective effects of VMA on HCl/ethanol-induced gastric mucosal injury may be partially due to the antiperoxidative effects of anthocyanidins".
In order to provide more information about VMA gastric protective effects, researchers examined the antiulcer effects of 3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-1-benzopyrylium chloride (IdB 1027,
an anthocyanidin from Vaccinium myrtillus) in various experimental models.
Orally, IdB 1027 inhibited all parameters associated with the onset of gastric ulcerations including anti-inflammatory drugs, ethanol, reserpine, histamine and duodenal ulceration induced by mercaptamine.
Furthermore, IdB 1027 also protected the stomach against chronic gastric ulcers induced by acetic acid.
Moreover, IdB 1027 in rat model did not affect gastric secretion in pylorus-ligated rats and increased gastric mucus in normal animals both in the absence and in the presence of indomethacin treatment.
In other words, IdB 1027 possessed a promising antiulcer activity, probably by potentiating the defensive barriers of the gastrointestinal mucosa.
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of gastric ulcer, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The protective effect and action mechanism of Vaccinium myrtillus L. on gastric ulcer in mice by Ogawa K1, Oyagi A, Tanaka J, Kobayashi S, Hara H. (PubMed)
(2) Antiulcer activity of an anthocyanidin from Vaccinium myrtillus by Magistretti MJ1, Conti M, Cristoni A. (PubMed)
(3) Obesity and Gastric Ulcers by Dr. Nadia B. Pietrzykowska. (OMC community)
A gastric ulcer is one of the most common types of peptic ulcer disease which affects both the stomach and small intestines.
According to the epidemiological studies, gastric ulcer is caused either by the infection of bacterium Helicobacter pylori (H. pylori) or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin.
Most common symptoms are burning sensation or pain in the stomach. Most patients with gastric ulcer have pain that intensifies on empty stomach, depending on the severity of the condition.
Some patients with gastric ulcer also experience persistent dull pain in the stomach, unintended weight loss, nausea or vomiting and bloating and acid reflux.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility of a gastric ulcer.
Conventionally, most cases of gastric ulcer can be treated successfully depending on the cause, including medicine or surgery if the medicine failed.
Out of many risk factors that cause a gastric ulcer, some researchers suggested there is a correlation between obesity and gastritis as well as gastric ulcers.
Dr. Nadia B. Pietrzykowska said, "Excess body weight has been linked to various abdominal ailments. These may include abdominal pain, bloating, vomiting, heartburn, diarrhea or constipation".
And, "Scientific studies are also increasingly reporting a correlation between obesity and gastritis as well as gastric ulcers. A recent, large study that specifically focused on analyzing gastric and duodenal ulcers confirmed that excess weight predisposed individuals to gastric ulcers when compared to their normal-weight counterparts".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the testing of the effect of Vaccinium myrtillus L. anthocyanoside (VMA) used as a folk medicine to treat diseases related to gastric ulcers in northern Europe, researchers investigated the protective effects of VMA on gastric mucosal damage in a murine gastric ulcer model.
During the experiment, oral administration of VMA (10, 30 and 100 mg/kg) significantly protected gastric mucosa against HCl/ethanol-induced gastric ulcers.
VMA protected the stomach by inhibiting lipid peroxide levels in a concentration-dependent manner and exhibiting the high scavenging activity against the superoxide anion radical (·O(2) (-) ) and the hydroxyl radical (·OH).
The antioxidant activity in VMA was found to be attributed by the presence of anthocyanidins and delphinidin.
Based on the findings, Dr. Ogawa K, the lead scientist said, "These findings indicate that the protective effects of VMA on HCl/ethanol-induced gastric mucosal injury may be partially due to the antiperoxidative effects of anthocyanidins".
In order to provide more information about VMA gastric protective effects, researchers examined the antiulcer effects of 3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-1-benzopyrylium chloride (IdB 1027,
an anthocyanidin from Vaccinium myrtillus) in various experimental models.
Orally, IdB 1027 inhibited all parameters associated with the onset of gastric ulcerations including anti-inflammatory drugs, ethanol, reserpine, histamine and duodenal ulceration induced by mercaptamine.
Furthermore, IdB 1027 also protected the stomach against chronic gastric ulcers induced by acetic acid.
Moreover, IdB 1027 in rat model did not affect gastric secretion in pylorus-ligated rats and increased gastric mucus in normal animals both in the absence and in the presence of indomethacin treatment.
In other words, IdB 1027 possessed a promising antiulcer activity, probably by potentiating the defensive barriers of the gastrointestinal mucosa.
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of gastric ulcer, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The protective effect and action mechanism of Vaccinium myrtillus L. on gastric ulcer in mice by Ogawa K1, Oyagi A, Tanaka J, Kobayashi S, Hara H. (PubMed)
(2) Antiulcer activity of an anthocyanidin from Vaccinium myrtillus by Magistretti MJ1, Conti M, Cristoni A. (PubMed)
(3) Obesity and Gastric Ulcers by Dr. Nadia B. Pietrzykowska. (OMC community)
Sunday, September 8, 2019
Green Tea In Alleviated Symptoms, Risk, Progression and Treatment of Polymyalgia Arthritis (Rheumatica)
Green tea may have a therapeutic and positive effect in reduced symptoms, risk, progression and treatment of polymyalgia arthritis (rheumatica), some scientists suggested.
Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.
Polymyalgia rheumatica is an inflammatory disease with muscle pain and stiffness, especially in the shoulders, affecting mostly older adults beyond the age of 65.
In an animal study of inflammatory diseases induced by injection of LPS, application of green tea bioactive polyphenols EGCG improved the antioxidant status of the host and decreased the production of inflammatory factors, including PMR through its antioxidant properties.
Further analysis suggested that application of EGCG reduced symptoms of inflammation such as pain, tension, stiffness, swelling of the infectious site without affecting the function of the immune system in protection against microorganisms invasion through inhibiting over-expression of tumor necrosis alpha(TNF-α) involved in the systematic inflammatory response to the acute phase of infection.
The bioactive compound also inhibited reactive oxygen species (ROS) in stimulated production of inflammatory cytokines through free radicals chain reactions in facilitated inflammation and precipitated skeletal muscle dysfunction and degradation by infiltrating immune cells to induce direct injury to muscle tissue or activating catabolic signaling.
In fact, overproduction of ROS increased continuously expression of mitochondria, NAD(P)H oxidases, xanthine oxidoreductases, and nitric oxide synthases caused an imbalance of the free radicals and antioxidant ratio, in orchestrated oxidative stress to muscle cells.
The further evaluation suggested that green tea EGCG reduced expression of interleukin 6 (IL-6), with function in response to infections and tissue injuries.
Long term overproduction of IL 6 due to the duo factors as a pro and anti-inflammatory protein may increase high-level concentrations of serum amyloid A (SAA), which has been found to induce serious complication of several chronic inflammatory diseases through generated and deposited amyloid A amyloidosis into the extracellular space in an abnormal, insoluble, fibrillar form,
Moreover, EGCG also attenuated levels of nuclear factor kappa B (NF-κB) in regulated innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses through activation of tumor necrosis factor-alpha (TNF-α) in promoted muscle wasting, leading to muscle atrophy in the induction of pain and stiffness and swelling.
Importantly, the application of green tea EGCG enhanced the natural antioxidant enzymes in the host such as glutathione, an antioxidant enzyme produced naturally found in every cell and tissue of the body.
These actions together with antioxidant initiated by injection of green tea EGCG stimulated cell regeneration, preserved the muscle cells and tissues and prevented muscle tension to precipitate polymyalgia arthritis.
Deficiency of glutathione levels was found to associate to the early development of Polymyalgia Arthritis in facilitated symptoms of pain, stiffness, achiness, fatigue, and fever.
Differentiation of the above was supported by conventional medicine corticosteroids, a powerful anti-inflammatory drugs with function to target pro-inflammation cytokines in relieving stiffness and pain in patients with polymyalgia arthritis.
Taken together, Green tea and its bioactive polyphenols EGCG may be considered a functional food for alleviating symptoms, risk, progression and treatment of polymyalgia arthritis (rheumatica). However, ingestion green tea supplements should be taken with extreme care as acute liver toxicity has been reported in several medical literature.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3.(PubMed)
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)
(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM.(PubMed)
Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.
Polymyalgia rheumatica is an inflammatory disease with muscle pain and stiffness, especially in the shoulders, affecting mostly older adults beyond the age of 65.
In an animal study of inflammatory diseases induced by injection of LPS, application of green tea bioactive polyphenols EGCG improved the antioxidant status of the host and decreased the production of inflammatory factors, including PMR through its antioxidant properties.
Further analysis suggested that application of EGCG reduced symptoms of inflammation such as pain, tension, stiffness, swelling of the infectious site without affecting the function of the immune system in protection against microorganisms invasion through inhibiting over-expression of tumor necrosis alpha(TNF-α) involved in the systematic inflammatory response to the acute phase of infection.
The bioactive compound also inhibited reactive oxygen species (ROS) in stimulated production of inflammatory cytokines through free radicals chain reactions in facilitated inflammation and precipitated skeletal muscle dysfunction and degradation by infiltrating immune cells to induce direct injury to muscle tissue or activating catabolic signaling.
In fact, overproduction of ROS increased continuously expression of mitochondria, NAD(P)H oxidases, xanthine oxidoreductases, and nitric oxide synthases caused an imbalance of the free radicals and antioxidant ratio, in orchestrated oxidative stress to muscle cells.
The further evaluation suggested that green tea EGCG reduced expression of interleukin 6 (IL-6), with function in response to infections and tissue injuries.
Long term overproduction of IL 6 due to the duo factors as a pro and anti-inflammatory protein may increase high-level concentrations of serum amyloid A (SAA), which has been found to induce serious complication of several chronic inflammatory diseases through generated and deposited amyloid A amyloidosis into the extracellular space in an abnormal, insoluble, fibrillar form,
Moreover, EGCG also attenuated levels of nuclear factor kappa B (NF-κB) in regulated innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses through activation of tumor necrosis factor-alpha (TNF-α) in promoted muscle wasting, leading to muscle atrophy in the induction of pain and stiffness and swelling.
Importantly, the application of green tea EGCG enhanced the natural antioxidant enzymes in the host such as glutathione, an antioxidant enzyme produced naturally found in every cell and tissue of the body.
These actions together with antioxidant initiated by injection of green tea EGCG stimulated cell regeneration, preserved the muscle cells and tissues and prevented muscle tension to precipitate polymyalgia arthritis.
Deficiency of glutathione levels was found to associate to the early development of Polymyalgia Arthritis in facilitated symptoms of pain, stiffness, achiness, fatigue, and fever.
Differentiation of the above was supported by conventional medicine corticosteroids, a powerful anti-inflammatory drugs with function to target pro-inflammation cytokines in relieving stiffness and pain in patients with polymyalgia arthritis.
Taken together, Green tea and its bioactive polyphenols EGCG may be considered a functional food for alleviating symptoms, risk, progression and treatment of polymyalgia arthritis (rheumatica). However, ingestion green tea supplements should be taken with extreme care as acute liver toxicity has been reported in several medical literature.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3.(PubMed)
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)
(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM.(PubMed)
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