Green tea may have a therapeutic and positive effect in reduced risk and treatment of intestinal ischemia, some scientists suggested.
Intestinal ischemia is a serious medical condition characterized by reduced blood flow to the
intestines.
In the evaluated 3 groups of male rats randomly assigned to Group I (ischemia-reperfusion, I/R) underwent I/R of the intestine (30 min of ischemia followed by 1 h of reperfusion). Group II (green tea + I/R) was given green tea for 2 wk before inducing I/R. Group III (control) with sham I/R, researchers found that injection of green tea group showed an impressive restoration of intestinal mucosa in compared to ischemia-reperfusion (I/R) group.
In observation of cellular antioxidant profile (superoxide dismutase and catalase), green tea group expressed a significant improvement of antioxidants similar to those of group III and in compared to group II.
The expressions of cellular proliferation markers (proliferating cell nuclear antigen and Ki-67) in regulated intestinal cell division and proliferation were also increased by green tea application.
The above illustration indicated that long term intake of green tea injection may exhibit strong protection against the intestinal mucosa from injury.
Further differentiation of the effect of Quercetin, the bioactive substance of tea against experimental ischemia-reperfusion (IR) injury of the small intestine in rats, found that quercetin administrated intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following reperfusion periods lasting 1, 4 and 24h significant decreases cyclooxygenase-2 (COX-2) enzyme in the epithelial lining of the intestinal villi in expression of normal cell apoptosis only during 24h of reperfusion in a late phase of IR injury in comparison with the control group.
According to the observation of the morphology of COX-2 positive cells, COX-2 positivity was found particularly in goblet cells with function in secreted the main component of mucus.of the intestinal villi epithelium and enteroendocrine cells found in the wall of the gut that secrete hormones that regulate glucose levels, food intake, and stomach emptying respectively, in the glandular epithelium in the group I mice in compared to significantly lesser levels in green tea group.
Dr. Tóth Š, the lead authors at the joint study said," quercetin application attenuated mucosal damage from IR injury by inhibiting neutrophil infiltration which was demonstrated by a lower number of myeloperoxidase positive cells in the lamina propria".
In another similar study with male-specific pathogen-free (SPF) Charles River Wistar rats were used in the experiment with quercetin administered intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following 24h lasting reperfusion period., researchers at the joint study lead by the Pavol Jozef Safarik University, also indicated that application of quercetin increases the production of anti-inflammatory cytokine IL10 observed by analysis of the blood sample and jejunal tissue and in the number of CD68-positive cells in the lamina propria mucosae (p<0.001) in initiation of production of new blood vessels growth and inflammatory cytokines in compared to control group.
Dr. Curgali K, the lead authors, after taking into account of other con-founders, said, "the preventive application of quercetin before induction of jejunal IRI stimulates faster jejunal mucosa restoration and it seems to have immunomodulatory and anti-inflammatory effects" and "CD68-positive macrophages could have crucial role in this process since they work as both growth factor and cytokine producers".
Taken together, green tea with abundant bioactive phytochemicals such as quercetin may be considered as a functional food in reduced risk and prevented the onset of intestinal ischemia. People with high risk in the development of intestinal ischemia may consider adding 1 or 2 cups of green tea into their daily diet.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of green tea on intestinal ischemia-reperfusion injury by Abdeen SM1, Mathew TC, Dashti HM, Asfar S.(PubMed)
(2) Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa by Tóth Š1, Jonecová Z1, Čurgali K1, Maretta M2, Šoltés J1, Švaňa M1, Kalpadikis T1, Caprnda M3, Adamek M4, Rodrigo L5, Kruzliak P6.(PubMed)
(3) Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells by Curgali K1, Toth S1, Jonecova Z1, Maretta M2, Kalpakidis T1, Petriskova I1, Kusnier M1, Soltes J1, Svana M1, Caprnda M3, Delev D4, Rodrigo L5, Mechirova E1, Kruzliak P6.(PubMed)
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