Hyperlipidemia is a condition of abnormally high blood lipid in the bloodstream a major cause of plaque accumulation on the arterial wall that leads to the increased risk of heart disease and stroke.
Cholesterol produced either by the liver or fat intake is essential to aid the digestive system in digesting foods and absorbing nutrient before passing them to other parts of the body, build a strong cell wall, produce vitamin D and steroid hormone.
There are 2 main types of cholesterol. The low-density lipoprotein (LDL) which carries the aforementioned function and the high-density lipoprotein (HDL)which returns the cholesterol back to the liver for reuse in the future.
The healthy blood cholesterol ratio of total blood cholesterol of LDL/ HDL is any numbers that are less than 4.
People with high blood cholesterol are asymptomatic. Conventionally, the condition can be lowered by regular intake of blood cholesterol-lowering medicine.
Most common risk factors that cause the onset of high blood cholesterol are unhealthy diet and physical inactivity.
Some researchers in the examination of the widespread high blood cholesterol over the past few decades probably are associated with the promotion of the high-fat diet in the US.
Dr. Cole TG, the lead scientist wrote," In normals, dietary cholesterol increases LDL production and decreases LDL receptor-related LDL clearance, resulting in elevations in LDL cholesterol levels of approximately 30 mg/dL".
Therefore, by changing behaviors in lifestyle, you may just be doing fine without medication. Please sure you tale to your doctor before withholding.
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
On finding a natural compound for the treatment of hyperlipidemia with no side effects, researchers examined the efficacy of Cucumber (Cucumis sativus) seed, used traditionally as a lipid-lowering nutritional supplement.
The randomized double-blind placebo-controlled clinical trial included hyperlipidemic patients with inclusion criteria randomly and equally assigned to either Cucumis or placebo groups or one medicinal or placebo capsule, once daily with food for 6 weeks.
According to the tested assays obtained from 23 patients in Cucumis group and 23 patients in the placebo group completed the study, cucumber seed extract-treated group showed a significant reduction of total cholesterol, and BMI index compared to baseline taken before the treatment
The extract also increased the levels of high-density lipoprotein (HLD) compared to placebo.
More precisely, at a concentration of daily dose of 500 mg, the consumption of C. sativus seed extract daily, exerted strong effects on serum lipid profile in tested adult hyperlipidemic patients.
In other words, daily injection at the ceratin dose may have a desirable effect in the prevention of hyperlipidemia in facilitating the onset of cholesterol build-up on the arteries and risk of cardiovascular disease.
Based on the results, researchers said, "Cucumber seed could be considered as a food supplement for treatment of dyslipidemia".
Taken altogether, cucumber may be used for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of the Effects of Cucumis sativus Seed Extract on Serum Lipids in Adult Hyperlipidemic Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial by Soltani R1, Hashemi M2, Farazmand A1, Asghari G3, Heshmat-Ghahdarijani K2, Kharazmkia A4, Ghanadian SM. (PubMed)
(2) Effects of high cholesterol high fat diet on plasma lipoproteins in familial hypercholesterolemia by Cole TG, Pfleger B, Hitchins O, Schonfeld G. (PubMed)
Thursday, September 12, 2019
Phytochemical Betacyanins Inhibits the Parameters Which Cause the Onset of Cognitive Deficit
Cognitive deficit is a medical condition associated with the impairment of a person's mental processes and the ability to acquire information and knowledge that interact with the outside world.
Most common causes of cognitive deficit include the genetic preposition, birth defects that affect the central nervous system such as Down syndrome and fragile X syndrome, malnutrition, prematurity, and conditions that were caused decreased oxygen to the brain.
Some researchers suggested that age degeneration, neurons injury that causes the death of some neurons involved in cognition, brain cancer in the cognitive region and environmental factors also associated with the risk of cognitive deficit.
Some early signs and symptoms of cognitive deficits may include signs of global developmental delay in childhood such as language, walking, self-care skills, and/or imitative play, delay cognitive skill compared to the most children in the same age, particularly difficult in performing of school works.
If your child has some of the social, adaptive, cognitive, language, gross motor and fine motor problem, please check with his/her doctor to rule out the possibility of cognitive deficit.
As of today, there is no cure for the cognitive deficit. The aim of the treatment is to improve the quality of life and reduce symptoms and delay the progression of the diseases.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential and natural ingredient for the treatment of cognitive deficit, researchers assessed the protective effect of betacyanins isolated from Portulaca oleracea L. against the D-galactose (D-gal)-induced neurotoxicity in mice.
Based on the behavioral tests, D-galactose (D-gal)-induced neurotoxicity in mice treated by betacyanins showed a strong effect on the improvement of learning and memory impairments.
Additionally, the levels of brain antioxidant levels such as superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) in D-gal-treated mice were significantly increased by the injection of betacyanins.
Furthermore, lipid peroxidation product found in the brain tissues and neurons such as malondialdehyde (MDA) was decreased by betacyanin administration.
Moreover, levels of the activities of SOD, CAT GR, and GPx in the mouse brain, had a significant negative correlation compared to the positive correlation of the level of MDA with the mouse cognitive impairment.
In other words, oxidative stress caused by D-galactose (D-gal)-induced neurotoxicity induced low levels of antioxidants enzymes such as SOD, CAT GR and GPx in the mouse brain were restored by the injection of betacyanins.
Based on the finding, researchers wrote in the final report, "These results suggest that the neuroprotective effect of betacyanins against D-gal-induced neurotoxicity might be caused, at least in part, by an increase in the activities of antioxidant enzymes with a reduction in lipid peroxidation" and "the betacyanins had a more pronounced effect on ameliorating cognition deficits in mice".
Taken altogether, betacyanins may be considered a remedy for the prevention and treatment of cognition deficits, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betacyanins from Portulaca oleracea L. ameliorate cognition deficits and attenuate oxidative induced by D-galactose in the brains of senescent mice by Chang-Quan Wang, and Gui-Qin Yang. (Research Gate)
Most common causes of cognitive deficit include the genetic preposition, birth defects that affect the central nervous system such as Down syndrome and fragile X syndrome, malnutrition, prematurity, and conditions that were caused decreased oxygen to the brain.
Some researchers suggested that age degeneration, neurons injury that causes the death of some neurons involved in cognition, brain cancer in the cognitive region and environmental factors also associated with the risk of cognitive deficit.
Some early signs and symptoms of cognitive deficits may include signs of global developmental delay in childhood such as language, walking, self-care skills, and/or imitative play, delay cognitive skill compared to the most children in the same age, particularly difficult in performing of school works.
If your child has some of the social, adaptive, cognitive, language, gross motor and fine motor problem, please check with his/her doctor to rule out the possibility of cognitive deficit.
As of today, there is no cure for the cognitive deficit. The aim of the treatment is to improve the quality of life and reduce symptoms and delay the progression of the diseases.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential and natural ingredient for the treatment of cognitive deficit, researchers assessed the protective effect of betacyanins isolated from Portulaca oleracea L. against the D-galactose (D-gal)-induced neurotoxicity in mice.
Based on the behavioral tests, D-galactose (D-gal)-induced neurotoxicity in mice treated by betacyanins showed a strong effect on the improvement of learning and memory impairments.
Additionally, the levels of brain antioxidant levels such as superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) in D-gal-treated mice were significantly increased by the injection of betacyanins.
Furthermore, lipid peroxidation product found in the brain tissues and neurons such as malondialdehyde (MDA) was decreased by betacyanin administration.
Moreover, levels of the activities of SOD, CAT GR, and GPx in the mouse brain, had a significant negative correlation compared to the positive correlation of the level of MDA with the mouse cognitive impairment.
In other words, oxidative stress caused by D-galactose (D-gal)-induced neurotoxicity induced low levels of antioxidants enzymes such as SOD, CAT GR and GPx in the mouse brain were restored by the injection of betacyanins.
Based on the finding, researchers wrote in the final report, "These results suggest that the neuroprotective effect of betacyanins against D-gal-induced neurotoxicity might be caused, at least in part, by an increase in the activities of antioxidant enzymes with a reduction in lipid peroxidation" and "the betacyanins had a more pronounced effect on ameliorating cognition deficits in mice".
Taken altogether, betacyanins may be considered a remedy for the prevention and treatment of cognition deficits, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betacyanins from Portulaca oleracea L. ameliorate cognition deficits and attenuate oxidative induced by D-galactose in the brains of senescent mice by Chang-Quan Wang, and Gui-Qin Yang. (Research Gate)
Wednesday, September 11, 2019
Herbal Bilberry in the Prevention and Treatment of Psoriasis
Psoriasis is an autoimmune disease caused by speeding up the life cycle of skin cells that lead to patches of abnormal skin.
Psoriasis may be localized which causes red, dry, itchy, and scaly skin patches in the affected area.
In cases of severity, psoriasis can cover the body completely.
Some patients also experience symptoms of thickened, pitted or ridged nails and swollen and stiff joints.
If you experience some of the aforementioned symptoms, please check with your doctor for preventive measure.
The causes of psoriasis are not identified, however, researchers believed that genetic proposition exacerbated by certain factors such as weather, injury, illness, or stress are some of the most causable factors that induce the onset of the condition.
Other risk factors associated with psoriasis may include skin injury that did not heal properly, people who are obese and side effects of long term use of certain medicines such as oral steroids.
Some researchers suggested smoking that has a strong impact on the immune system may also be one of the major causes of psoriasis in smokers.
Dr. wrote, "A number of inflammatory immune-related conditions have been associated with smoking, including psoriasis. Smoking affects the onset of psoriasis".
And, " Several pathophysiological mechanisms may explain the association of psoriasis with smoking, including oxidative stress, interaction with signaling pathways active in psoriasis, and vascular influences".
The findings strongly suggested, if you smoke, you are at a higher risk of psoriasis
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find a natural and therapeutic ingredient for the treatment of psoriasis, researchers
a cosmeceutical formulation based on boswellic acids and Vaccinium myrtillus seed oil in patients with psoriasis.
The double-blind study is to compare a novel BA formulation (containing Bosexil(®), INCI [International Nomenclature of Cosmetic Ingredients]: lecithin, Boswellia serrata resin extract) with a placebo formulation and a formulation of Vaccinium myrtillus (Bilberry) seed oil.
More precisely, patients with psoriasis or erythematous eczema were randomly assigned, in a 1:1:1 ratio, to Bosexil(®), V. myrtillus seed oil, or placebo.
During the experiment, Bosexil(®) and the V. myrtillus seed oil treatment significantly improved psoriasis, scales in comparison with placebo.
Formulation of Vaccinium myrtillus seed oil exerted a similar effect as those of Bosexil(®) without any case of worsening compared to placebo.
Furthermore, V. myrtillus seed oil improved itch and erythema in 66.7% and 77.8% of patients, respectively compared to the Bosexil(®) formulation of (60% of cases) and erythema (60% of cases) without any case of worsening, respectively.
The results clearly suggested that V. myrtillus seed oil and Bosexil(®) formulation process a strong anti-psoriasis activity without side effects.
Taken altogether, bilberry may be considered a functioning remedy for the treatment of psoriasis, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis by Togni S1, Maramaldi G1, Di Pierro F2, Biondi M. (PubMed)
(2) Psoriasis and smoking: links and risks by Luigi Naldi. (PMC)
Psoriasis may be localized which causes red, dry, itchy, and scaly skin patches in the affected area.
In cases of severity, psoriasis can cover the body completely.
Some patients also experience symptoms of thickened, pitted or ridged nails and swollen and stiff joints.
If you experience some of the aforementioned symptoms, please check with your doctor for preventive measure.
The causes of psoriasis are not identified, however, researchers believed that genetic proposition exacerbated by certain factors such as weather, injury, illness, or stress are some of the most causable factors that induce the onset of the condition.
Other risk factors associated with psoriasis may include skin injury that did not heal properly, people who are obese and side effects of long term use of certain medicines such as oral steroids.
Some researchers suggested smoking that has a strong impact on the immune system may also be one of the major causes of psoriasis in smokers.
Dr. wrote, "A number of inflammatory immune-related conditions have been associated with smoking, including psoriasis. Smoking affects the onset of psoriasis".
And, " Several pathophysiological mechanisms may explain the association of psoriasis with smoking, including oxidative stress, interaction with signaling pathways active in psoriasis, and vascular influences".
The findings strongly suggested, if you smoke, you are at a higher risk of psoriasis
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find a natural and therapeutic ingredient for the treatment of psoriasis, researchers
a cosmeceutical formulation based on boswellic acids and Vaccinium myrtillus seed oil in patients with psoriasis.
The double-blind study is to compare a novel BA formulation (containing Bosexil(®), INCI [International Nomenclature of Cosmetic Ingredients]: lecithin, Boswellia serrata resin extract) with a placebo formulation and a formulation of Vaccinium myrtillus (Bilberry) seed oil.
More precisely, patients with psoriasis or erythematous eczema were randomly assigned, in a 1:1:1 ratio, to Bosexil(®), V. myrtillus seed oil, or placebo.
During the experiment, Bosexil(®) and the V. myrtillus seed oil treatment significantly improved psoriasis, scales in comparison with placebo.
Formulation of Vaccinium myrtillus seed oil exerted a similar effect as those of Bosexil(®) without any case of worsening compared to placebo.
Furthermore, V. myrtillus seed oil improved itch and erythema in 66.7% and 77.8% of patients, respectively compared to the Bosexil(®) formulation of (60% of cases) and erythema (60% of cases) without any case of worsening, respectively.
The results clearly suggested that V. myrtillus seed oil and Bosexil(®) formulation process a strong anti-psoriasis activity without side effects.
Taken altogether, bilberry may be considered a functioning remedy for the treatment of psoriasis, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis by Togni S1, Maramaldi G1, Di Pierro F2, Biondi M. (PubMed)
(2) Psoriasis and smoking: links and risks by Luigi Naldi. (PMC)
Green Tea in Ameliorated Risk and Prevented Onset of Intestinal Ischemia
Green tea may have a therapeutic and positive effect in reduced risk and treatment of intestinal ischemia, some scientists suggested.
Intestinal ischemia is a serious medical condition characterized by reduced blood flow to the
intestines.
In the evaluated 3 groups of male rats randomly assigned to Group I (ischemia-reperfusion, I/R) underwent I/R of the intestine (30 min of ischemia followed by 1 h of reperfusion). Group II (green tea + I/R) was given green tea for 2 wk before inducing I/R. Group III (control) with sham I/R, researchers found that injection of green tea group showed an impressive restoration of intestinal mucosa in compared to ischemia-reperfusion (I/R) group.
In observation of cellular antioxidant profile (superoxide dismutase and catalase), green tea group expressed a significant improvement of antioxidants similar to those of group III and in compared to group II.
The expressions of cellular proliferation markers (proliferating cell nuclear antigen and Ki-67) in regulated intestinal cell division and proliferation were also increased by green tea application.
The above illustration indicated that long term intake of green tea injection may exhibit strong protection against the intestinal mucosa from injury.
Further differentiation of the effect of Quercetin, the bioactive substance of tea against experimental ischemia-reperfusion (IR) injury of the small intestine in rats, found that quercetin administrated intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following reperfusion periods lasting 1, 4 and 24h significant decreases cyclooxygenase-2 (COX-2) enzyme in the epithelial lining of the intestinal villi in expression of normal cell apoptosis only during 24h of reperfusion in a late phase of IR injury in comparison with the control group.
According to the observation of the morphology of COX-2 positive cells, COX-2 positivity was found particularly in goblet cells with function in secreted the main component of mucus.of the intestinal villi epithelium and enteroendocrine cells found in the wall of the gut that secrete hormones that regulate glucose levels, food intake, and stomach emptying respectively, in the glandular epithelium in the group I mice in compared to significantly lesser levels in green tea group.
Dr. Tóth Š, the lead authors at the joint study said," quercetin application attenuated mucosal damage from IR injury by inhibiting neutrophil infiltration which was demonstrated by a lower number of myeloperoxidase positive cells in the lamina propria".
In another similar study with male-specific pathogen-free (SPF) Charles River Wistar rats were used in the experiment with quercetin administered intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following 24h lasting reperfusion period., researchers at the joint study lead by the Pavol Jozef Safarik University, also indicated that application of quercetin increases the production of anti-inflammatory cytokine IL10 observed by analysis of the blood sample and jejunal tissue and in the number of CD68-positive cells in the lamina propria mucosae (p<0.001) in initiation of production of new blood vessels growth and inflammatory cytokines in compared to control group.
Dr. Curgali K, the lead authors, after taking into account of other con-founders, said, "the preventive application of quercetin before induction of jejunal IRI stimulates faster jejunal mucosa restoration and it seems to have immunomodulatory and anti-inflammatory effects" and "CD68-positive macrophages could have crucial role in this process since they work as both growth factor and cytokine producers".
Taken together, green tea with abundant bioactive phytochemicals such as quercetin may be considered as a functional food in reduced risk and prevented the onset of intestinal ischemia. People with high risk in the development of intestinal ischemia may consider adding 1 or 2 cups of green tea into their daily diet.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of green tea on intestinal ischemia-reperfusion injury by Abdeen SM1, Mathew TC, Dashti HM, Asfar S.(PubMed)
(2) Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa by Tóth Š1, Jonecová Z1, Čurgali K1, Maretta M2, Šoltés J1, Švaňa M1, Kalpadikis T1, Caprnda M3, Adamek M4, Rodrigo L5, Kruzliak P6.(PubMed)
(3) Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells by Curgali K1, Toth S1, Jonecova Z1, Maretta M2, Kalpakidis T1, Petriskova I1, Kusnier M1, Soltes J1, Svana M1, Caprnda M3, Delev D4, Rodrigo L5, Mechirova E1, Kruzliak P6.(PubMed)
Intestinal ischemia is a serious medical condition characterized by reduced blood flow to the
intestines.
In the evaluated 3 groups of male rats randomly assigned to Group I (ischemia-reperfusion, I/R) underwent I/R of the intestine (30 min of ischemia followed by 1 h of reperfusion). Group II (green tea + I/R) was given green tea for 2 wk before inducing I/R. Group III (control) with sham I/R, researchers found that injection of green tea group showed an impressive restoration of intestinal mucosa in compared to ischemia-reperfusion (I/R) group.
In observation of cellular antioxidant profile (superoxide dismutase and catalase), green tea group expressed a significant improvement of antioxidants similar to those of group III and in compared to group II.
The expressions of cellular proliferation markers (proliferating cell nuclear antigen and Ki-67) in regulated intestinal cell division and proliferation were also increased by green tea application.
The above illustration indicated that long term intake of green tea injection may exhibit strong protection against the intestinal mucosa from injury.
Further differentiation of the effect of Quercetin, the bioactive substance of tea against experimental ischemia-reperfusion (IR) injury of the small intestine in rats, found that quercetin administrated intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following reperfusion periods lasting 1, 4 and 24h significant decreases cyclooxygenase-2 (COX-2) enzyme in the epithelial lining of the intestinal villi in expression of normal cell apoptosis only during 24h of reperfusion in a late phase of IR injury in comparison with the control group.
According to the observation of the morphology of COX-2 positive cells, COX-2 positivity was found particularly in goblet cells with function in secreted the main component of mucus.of the intestinal villi epithelium and enteroendocrine cells found in the wall of the gut that secrete hormones that regulate glucose levels, food intake, and stomach emptying respectively, in the glandular epithelium in the group I mice in compared to significantly lesser levels in green tea group.
Dr. Tóth Š, the lead authors at the joint study said," quercetin application attenuated mucosal damage from IR injury by inhibiting neutrophil infiltration which was demonstrated by a lower number of myeloperoxidase positive cells in the lamina propria".
In another similar study with male-specific pathogen-free (SPF) Charles River Wistar rats were used in the experiment with quercetin administered intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following 24h lasting reperfusion period., researchers at the joint study lead by the Pavol Jozef Safarik University, also indicated that application of quercetin increases the production of anti-inflammatory cytokine IL10 observed by analysis of the blood sample and jejunal tissue and in the number of CD68-positive cells in the lamina propria mucosae (p<0.001) in initiation of production of new blood vessels growth and inflammatory cytokines in compared to control group.
Dr. Curgali K, the lead authors, after taking into account of other con-founders, said, "the preventive application of quercetin before induction of jejunal IRI stimulates faster jejunal mucosa restoration and it seems to have immunomodulatory and anti-inflammatory effects" and "CD68-positive macrophages could have crucial role in this process since they work as both growth factor and cytokine producers".
Taken together, green tea with abundant bioactive phytochemicals such as quercetin may be considered as a functional food in reduced risk and prevented the onset of intestinal ischemia. People with high risk in the development of intestinal ischemia may consider adding 1 or 2 cups of green tea into their daily diet.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of green tea on intestinal ischemia-reperfusion injury by Abdeen SM1, Mathew TC, Dashti HM, Asfar S.(PubMed)
(2) Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa by Tóth Š1, Jonecová Z1, Čurgali K1, Maretta M2, Šoltés J1, Švaňa M1, Kalpadikis T1, Caprnda M3, Adamek M4, Rodrigo L5, Kruzliak P6.(PubMed)
(3) Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells by Curgali K1, Toth S1, Jonecova Z1, Maretta M2, Kalpakidis T1, Petriskova I1, Kusnier M1, Soltes J1, Svana M1, Caprnda M3, Delev D4, Rodrigo L5, Mechirova E1, Kruzliak P6.(PubMed)
Tuesday, September 10, 2019
Green Tea and Its Bioactive Polyphenols EGCG in Reduced Risk and Treatment of Hepatitis C
Green tea may have a therapeutic and positive effect in reduced risk and treatment of hepatitis C, some scientists suggested.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Hepatitis C is a medical condition induced by contaminated food intake containing hepatitis C virus (HCV). Hepatitis C has been found to associate with severe liver damage.
According to statistic, approximately 130–150 million people around the world are living with chronic HCV.
Green tea bioactive polyphenols Epigallocatechin-3-gallate (EGCG) in reduced risk and treatment of hepatitis was found to associate numbers of implications through various aspects.
In Huh7.5.1 cells, a HCV cell culture (HCVcc) system using a JFH1-GFP chimeric virus, application of green tea EGCG with 50 % effective concentration (EC(50)) of 17.9 μM demonstrated a strong effect in interrupted HCV progression through monitoring HCV RNA and protein levels in Huh7.5.1 cells infected with the JFH1 virus by preventing the mRNA in transferring infectious cell transcription in facilitated cell proliferation and division.
Importantly, injection of green tea at dose of 50 and 25 μM EGCG, expressed a significant inhibition of the presence of HCV after 2 and 5 passages in HCV cell culture (HCVcc) experiment, using an American Type Culture Collection (ATCC) reference strain, with little effect to the viral internal ribosome entry site (IRES) in initiated substitution of RNA sequences for viral protein synthesis in shutting off classic host translation to evade host immune response.
Notably, in comparison to the effect of green tea with potent anti-HCV activity
medicine, cyclosporin A and tamoxifen, researchers indicated that application of green tea showed a strong anti HCV viral activity, similarly to those of anti-hepatitis medicine through its antioxidant expression of flavonoids epigallocatechin gallate (EGCG) and 7,8-benzoflavone (α-naphthoflavone), observed in HCV cell culture (HCVcc) by blocking the entry point of the virus in initiated infection to host cells and stimulating the viral cell cycle arrest at the late stage of HCV life cycle, respectively
Interestingly, some researchers in the evaluation of green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) in hepatitis C infection suggested that EGCG processed anti-viral expression through interrupting the cross-link between HCV life cycle involving steps of entry, replication.
Injection of a concentration of 50 μM of EGCG was found to inhibit HCV infectivity by more than 90% at an early step of the viral life cycle.
Indeed, the interrupted property in blocking the HCV entry cycle to induce infection to the host cell was confirmed with HCV pseudo particles, an experiment model system in expression of cellular attachment which is the essential component of the HCV entry process.
Moreover, green tea EGCG also prevented attachment off of the virus to the cell surface in ameliorated HCV infection to the host cell without effecting viral replication and virion secretion outside of the host.
Taken together, green tea and its bioactive polyphenols EGCG may be considered as a functional food in reduced risk and combined with other standard medicine for the treatment of hepatitis C virus in the induction of acute and chronic liver diseases.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry by Calland N1, Albecka A, Belouzard S, Wychowski C, Duverlie G, Descamps V, Hober D, Dubuisson J, Rouillé Y, Séron K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate inhibits the replication cycle of hepatitis C virus by Chen C1, Qiu H, Gong J, Liu Q, Xiao H, Chen XW, Sun BL, Yang RG.(PubMed)
(3) A cell-based, microplate colorimetric screen identifies 7,8-benzoflavone and green tea gallate catechins as inhibitors of the hepatitis C virus by Fukazawa H1, Suzuki T, Wakita T, Murakami Y.(PubMed)
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Hepatitis C is a medical condition induced by contaminated food intake containing hepatitis C virus (HCV). Hepatitis C has been found to associate with severe liver damage.
According to statistic, approximately 130–150 million people around the world are living with chronic HCV.
Green tea bioactive polyphenols Epigallocatechin-3-gallate (EGCG) in reduced risk and treatment of hepatitis was found to associate numbers of implications through various aspects.
In Huh7.5.1 cells, a HCV cell culture (HCVcc) system using a JFH1-GFP chimeric virus, application of green tea EGCG with 50 % effective concentration (EC(50)) of 17.9 μM demonstrated a strong effect in interrupted HCV progression through monitoring HCV RNA and protein levels in Huh7.5.1 cells infected with the JFH1 virus by preventing the mRNA in transferring infectious cell transcription in facilitated cell proliferation and division.
Importantly, injection of green tea at dose of 50 and 25 μM EGCG, expressed a significant inhibition of the presence of HCV after 2 and 5 passages in HCV cell culture (HCVcc) experiment, using an American Type Culture Collection (ATCC) reference strain, with little effect to the viral internal ribosome entry site (IRES) in initiated substitution of RNA sequences for viral protein synthesis in shutting off classic host translation to evade host immune response.
Notably, in comparison to the effect of green tea with potent anti-HCV activity
medicine, cyclosporin A and tamoxifen, researchers indicated that application of green tea showed a strong anti HCV viral activity, similarly to those of anti-hepatitis medicine through its antioxidant expression of flavonoids epigallocatechin gallate (EGCG) and 7,8-benzoflavone (α-naphthoflavone), observed in HCV cell culture (HCVcc) by blocking the entry point of the virus in initiated infection to host cells and stimulating the viral cell cycle arrest at the late stage of HCV life cycle, respectively
Interestingly, some researchers in the evaluation of green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) in hepatitis C infection suggested that EGCG processed anti-viral expression through interrupting the cross-link between HCV life cycle involving steps of entry, replication.
Injection of a concentration of 50 μM of EGCG was found to inhibit HCV infectivity by more than 90% at an early step of the viral life cycle.
Indeed, the interrupted property in blocking the HCV entry cycle to induce infection to the host cell was confirmed with HCV pseudo particles, an experiment model system in expression of cellular attachment which is the essential component of the HCV entry process.
Moreover, green tea EGCG also prevented attachment off of the virus to the cell surface in ameliorated HCV infection to the host cell without effecting viral replication and virion secretion outside of the host.
Taken together, green tea and its bioactive polyphenols EGCG may be considered as a functional food in reduced risk and combined with other standard medicine for the treatment of hepatitis C virus in the induction of acute and chronic liver diseases.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry by Calland N1, Albecka A, Belouzard S, Wychowski C, Duverlie G, Descamps V, Hober D, Dubuisson J, Rouillé Y, Séron K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate inhibits the replication cycle of hepatitis C virus by Chen C1, Qiu H, Gong J, Liu Q, Xiao H, Chen XW, Sun BL, Yang RG.(PubMed)
(3) A cell-based, microplate colorimetric screen identifies 7,8-benzoflavone and green tea gallate catechins as inhibitors of the hepatitis C virus by Fukazawa H1, Suzuki T, Wakita T, Murakami Y.(PubMed)
Healthy Food Tomato Protects The Integrity of Neurons Against Neurological Disorders in Vivo
Neurological disorders are class of diseases associated with the brain, the spinal cord including the nerves that connect them.
Most common diseases of neurological disorders are dementia, including ALS. PD, Alzheimer's disease, birth defects of the brain and spinal cord, brain injury and tumor.
Back pain associated with the related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.
There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, and nutrition-related disease, environment, and physical injuries have been found to some major prevalent factors that induce the onset of neurological abnormalities.
Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen on post-stroke patients, difficulty reading and writing and poor cognitive abilities such as patients with dementia.
According to the American Addiction Center, if you experience some of the below symptoms persistently, inclduing headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural ingredient for the treatment of neurological inflammatory disease, researchers examined phytochemical lycopene isolated from tomatoes against experimental Parkinson's disease (PD).
The study included PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oral administration of different doses (5, 10 and 20 mg/kg/day).
All doses showed a strong effect in protecting MPTP induced depletion of striatal dopamine (DA) and its metabolites in a dose-dependent manner.
Application of all doses also attenuated MPTP-induced oxidative stress and motor abnormalities in mice treated with MPTP.
Furthermore, according to the western blot assay, lycopene protected the neurons against MPTP induced apoptosis through its antioxidant and antiapoptotic properties.
In other words, lycopene in different doses exerted a PD protective activity by restoring the neurochemicals, neuron apoptosis caused by overexpression of free radicals.
Based on the findings, researchers said, " lycopene reverses neurochemical deficits, oxidative stress, apoptosis and physiological abnormalities in PD mice and offers promise strategy in the treatment of this neurodegenerative disease".
Moreover, in Alzheimer's disease (AD), associated with neuroinflammation characterized by glial activation and release of proinflammatory mediators, researchers examined the efficacy of lycopene against β-Amyloid1-42 (Aβ1-42)-induced learning and memory impairment in an animal model.
In selected induced Aβ1-42 bilaterally followed by treatment with lycopene or rivastigmine for 14 days, lycopene remediated Aβ-induced learning and memory deficits in a dose-dependent manner.
Additionally, lycopene treated group showed to ameliorate the side effects of Aβ1-42-induced mitochondrial dysfunction along with a surge of proinflammatory cytokines (TNF-α, TGF-β, and IL-1β) and protein associated with inflammatory signaling and neuron apoptosis.
Dr. Sachdeva AK, the lead scientist after taking other factors into account, wrote, "The amelioration of Aβ1-42-induced spatial learning and memory impairment by lycopene could be linked, at least in part, to the inhibition of NF-κB activity and the down-regulation of expression of neuroinflammatory cytokines, suggesting that lycopene may be a potential candidate for AD treatment".
Taken altogether, tomatoes processed abundantly bioactive ingredient lycopene may be considered supplements for the prevention and treatment of angiotensin caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective effect of lycopene against MPTP induced experimental Parkinson's disease in mice by Prema A1, Janakiraman U1, Manivasagam T2, Thenmozhi AJ. (PubMed)
(2) Lycopene abrogates Aβ(1-42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer's disease by Sachdeva AK1, Chopra K. (PubMed)
(3) Neurological Problem Symptoms, Causes, and Effects by the American Addiction Center
Most common diseases of neurological disorders are dementia, including ALS. PD, Alzheimer's disease, birth defects of the brain and spinal cord, brain injury and tumor.
Back pain associated with the related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.
There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, and nutrition-related disease, environment, and physical injuries have been found to some major prevalent factors that induce the onset of neurological abnormalities.
Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen on post-stroke patients, difficulty reading and writing and poor cognitive abilities such as patients with dementia.
According to the American Addiction Center, if you experience some of the below symptoms persistently, inclduing headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural ingredient for the treatment of neurological inflammatory disease, researchers examined phytochemical lycopene isolated from tomatoes against experimental Parkinson's disease (PD).
The study included PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oral administration of different doses (5, 10 and 20 mg/kg/day).
All doses showed a strong effect in protecting MPTP induced depletion of striatal dopamine (DA) and its metabolites in a dose-dependent manner.
Application of all doses also attenuated MPTP-induced oxidative stress and motor abnormalities in mice treated with MPTP.
Furthermore, according to the western blot assay, lycopene protected the neurons against MPTP induced apoptosis through its antioxidant and antiapoptotic properties.
In other words, lycopene in different doses exerted a PD protective activity by restoring the neurochemicals, neuron apoptosis caused by overexpression of free radicals.
Based on the findings, researchers said, " lycopene reverses neurochemical deficits, oxidative stress, apoptosis and physiological abnormalities in PD mice and offers promise strategy in the treatment of this neurodegenerative disease".
Moreover, in Alzheimer's disease (AD), associated with neuroinflammation characterized by glial activation and release of proinflammatory mediators, researchers examined the efficacy of lycopene against β-Amyloid1-42 (Aβ1-42)-induced learning and memory impairment in an animal model.
In selected induced Aβ1-42 bilaterally followed by treatment with lycopene or rivastigmine for 14 days, lycopene remediated Aβ-induced learning and memory deficits in a dose-dependent manner.
Additionally, lycopene treated group showed to ameliorate the side effects of Aβ1-42-induced mitochondrial dysfunction along with a surge of proinflammatory cytokines (TNF-α, TGF-β, and IL-1β) and protein associated with inflammatory signaling and neuron apoptosis.
Dr. Sachdeva AK, the lead scientist after taking other factors into account, wrote, "The amelioration of Aβ1-42-induced spatial learning and memory impairment by lycopene could be linked, at least in part, to the inhibition of NF-κB activity and the down-regulation of expression of neuroinflammatory cytokines, suggesting that lycopene may be a potential candidate for AD treatment".
Taken altogether, tomatoes processed abundantly bioactive ingredient lycopene may be considered supplements for the prevention and treatment of angiotensin caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective effect of lycopene against MPTP induced experimental Parkinson's disease in mice by Prema A1, Janakiraman U1, Manivasagam T2, Thenmozhi AJ. (PubMed)
(2) Lycopene abrogates Aβ(1-42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer's disease by Sachdeva AK1, Chopra K. (PubMed)
(3) Neurological Problem Symptoms, Causes, and Effects by the American Addiction Center
Monday, September 9, 2019
Phytochemical Carotenoids Protects the Eyes of Elderly Against Age-Related Macular Degeneration
Age-related macular degeneration is a condition caused by the deterioration of the small central portion of the retina, known as the macula
Macular degeneration happened mostly in adults over 60, is one of the major cause of vision loss.
The exact causes of macular degeneration are not identified. As of today, researchers cannot explain why some elderly are susceptible to macular degeneration while others do not.
However, researchers do know that certain risk factors have been found epidemiologically to induce the risk of macular degeneration including aging, the disease has been found most commonly in people over 50, family history and genetics, race, macular degeneration is more common in Caucasians.
Smoking, obesity and medical condition such as cardiovascular disease are also associated with a higher risk of macular degeneration
There are 2 forms of macular degeneration found in the elderly
* The dry form is caused by the presence of yellow deposits, called drusen under the retina, in the macula. However, the elderly with increased was not at a higher risk of macular degeneration.
* The wet form is caused by the growth of abnormal blood vessels from the choroid, the vascular layer of the eye, underneath the retina.
Compared to the loss of vision of 10% of patients induced by the wet form, most patients of macular degeneration have the dry form which has been found to cause loss of some central vision.
Some researchers suggested that macular degeneration may also be caused by an unhealthy diet. Dr. Martha P. Montgomery wrote, "A 97-item Block food frequency questionnaire was used to gather diet information, and overall diet quality was measured using the Healthy Eating Index (HEI) and Alternate Healthy Eating Index (AHEI)".
And, "Participants in the highest quartile of diet quality had significantly reduced odds of AMD according to the AHEI score (0.54, 95% confidence interval 0.30 – 0.99) and non-significantly reduced odds of AMD according to the HEI (0.75, 0.41 – 1.38). Odds of AMD were also 51% lower in the highest quartile of fish intake compared to the lowest quartile (odds ratio = 0.49, 0.26 – 0.90)".
These results strongly suggested the risk of AMD is many folds higher in people who follow the Western diet compared to those who follow the Oriental diet.
Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
On finding a potential ingredient for the treatment of age-related macular degeneration (AMD), researchers examined the beneficial role for carotenoids in the prevention of AMD.
Epidemiologically, in a case-control study by comparing the risk AMD in subjects with late AMD, exudative AMD, and retinal pigment abnormalities with the presence of drusen, and an equal number of control subjects,
*Administration of lutein and zeaxanthin induced serum concentrations were not associated with the risk of AMD.
* Consumption of food sources of lutein and zeaxanthin (carotenoids) was associated with reducing the risk of macular degeneration.
* People with higher levels of lutein and zeaxanthin in the blood have a lower risk of AMD.
However, the reduced risk of lutein and zeaxanthin for AMD when levels of the carotenoids are elevated in the serum or diet was not consistent.
Based on the findings, researchers wrote, "Until scientifically sound knowledge is available we recommend for patients judged to be at risk for AMD to alter their diet to more dark green leafy vegetables, wear UV protective lenses and a hat when outdoors".
Taken altogether, carotenoids, particularly lutein and zeaxanthin may be considered a remedy for the prevention and treatment of age-related macular degeneration, pending to the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
Sources
(1) The role of the carotenoids, lutein, and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence by Maneli Mozaffarieh,1 Stefan Sacu,1 and Andreas Wedrich. (PMC)
(2) Overall diet quality and age-related macular degeneration by Martha P. Montgomery, M.H.S., Freya Kamel, Ph.D., M.P.H., Margaret A. Pericak-Vance, Ph.D., Jonathan L. Haines, Ph.D., Eric A. Postel, M.D., Anita Agarwal, M.D., Marie Richards, Ph.D., William K. Scott, Ph.D.,* and Silke Schmidt, Ph.D. (PMC)
Macular degeneration happened mostly in adults over 60, is one of the major cause of vision loss.
The exact causes of macular degeneration are not identified. As of today, researchers cannot explain why some elderly are susceptible to macular degeneration while others do not.
However, researchers do know that certain risk factors have been found epidemiologically to induce the risk of macular degeneration including aging, the disease has been found most commonly in people over 50, family history and genetics, race, macular degeneration is more common in Caucasians.
Smoking, obesity and medical condition such as cardiovascular disease are also associated with a higher risk of macular degeneration
There are 2 forms of macular degeneration found in the elderly
* The dry form is caused by the presence of yellow deposits, called drusen under the retina, in the macula. However, the elderly with increased was not at a higher risk of macular degeneration.
* The wet form is caused by the growth of abnormal blood vessels from the choroid, the vascular layer of the eye, underneath the retina.
Compared to the loss of vision of 10% of patients induced by the wet form, most patients of macular degeneration have the dry form which has been found to cause loss of some central vision.
Some researchers suggested that macular degeneration may also be caused by an unhealthy diet. Dr. Martha P. Montgomery wrote, "A 97-item Block food frequency questionnaire was used to gather diet information, and overall diet quality was measured using the Healthy Eating Index (HEI) and Alternate Healthy Eating Index (AHEI)".
And, "Participants in the highest quartile of diet quality had significantly reduced odds of AMD according to the AHEI score (0.54, 95% confidence interval 0.30 – 0.99) and non-significantly reduced odds of AMD according to the HEI (0.75, 0.41 – 1.38). Odds of AMD were also 51% lower in the highest quartile of fish intake compared to the lowest quartile (odds ratio = 0.49, 0.26 – 0.90)".
These results strongly suggested the risk of AMD is many folds higher in people who follow the Western diet compared to those who follow the Oriental diet.
Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
On finding a potential ingredient for the treatment of age-related macular degeneration (AMD), researchers examined the beneficial role for carotenoids in the prevention of AMD.
Epidemiologically, in a case-control study by comparing the risk AMD in subjects with late AMD, exudative AMD, and retinal pigment abnormalities with the presence of drusen, and an equal number of control subjects,
*Administration of lutein and zeaxanthin induced serum concentrations were not associated with the risk of AMD.
* Consumption of food sources of lutein and zeaxanthin (carotenoids) was associated with reducing the risk of macular degeneration.
* People with higher levels of lutein and zeaxanthin in the blood have a lower risk of AMD.
However, the reduced risk of lutein and zeaxanthin for AMD when levels of the carotenoids are elevated in the serum or diet was not consistent.
Based on the findings, researchers wrote, "Until scientifically sound knowledge is available we recommend for patients judged to be at risk for AMD to alter their diet to more dark green leafy vegetables, wear UV protective lenses and a hat when outdoors".
Taken altogether, carotenoids, particularly lutein and zeaxanthin may be considered a remedy for the prevention and treatment of age-related macular degeneration, pending to the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
Sources
(1) The role of the carotenoids, lutein, and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence by Maneli Mozaffarieh,1 Stefan Sacu,1 and Andreas Wedrich. (PMC)
(2) Overall diet quality and age-related macular degeneration by Martha P. Montgomery, M.H.S., Freya Kamel, Ph.D., M.P.H., Margaret A. Pericak-Vance, Ph.D., Jonathan L. Haines, Ph.D., Eric A. Postel, M.D., Anita Agarwal, M.D., Marie Richards, Ph.D., William K. Scott, Ph.D.,* and Silke Schmidt, Ph.D. (PMC)
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