The bowel formed a lower part of the digestive system consists of the small bowel (or small intestine) and the large bowel(colon and rectum).
The large bowel plays an essential role to absorb water, restore and remove waste.
Cancer is a class of medical condition caused alternation of cell DNA that starts on the surface of the inner lining of the tissue of a specific organ. Compared to a benign tumor, invasive tumor cells at the advanced stage can travel a distance away to infect other healthy tissue through blood and fluid circulation.
Colorectal Cancer is a medical condition caused by cell growth disorderly in the tissues of colon or rectum.
According to the statistics provided by the American Cancer Society in 2019, approximately
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in the US.
Furthermore, the overall, lifetime risk colorectal cancer of developing is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
Colorectal cancer is relatively very common and slowly growing and progressing cancer. It is the third most commonly diagnosed cancer in developed countries, including the U.S. and Canada.
Most patients with colorectal cancer at the early stage are assymptomatic. However, at the advanced stage patients might experience symptoms of changes in bowel habits, narrow stools, constipation, diarrhea, irritable bowel syndrome, intermittent, ulcerative colitis, Crohn's disease, diverticulosis, peptic ulcer disease, abdominal pain, accompanied by the general symptoms shared by other types of cancer.
Conventionally, treatment of colorectal cancer is totally depending on the stage of cancer, including localized(0), regional (1) and distance spread cancer (2 - nearby tissue, 3 - spread to the lymph node, 4, spread to organs and tissues)
Most common types of colorectal cancer are Adenocarcinomas which are originated in the surface of the inner layer that line the cavities and organs of the body.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.
On finding a potent compound for the treatment of colorectal cancer, researchers examined the effect of the aqueous extract and of its betalain pigment indicaxanthin (Ind), on the proliferation of human colorectal cancer Caco-2 cells.
According to the tested assays, administration of whole extract and Ind exerted a strong activity to induce apoptosis and anti-proliferation at nutritionally relevant amounts, with IC50 400±25 mg fresh pulp equivalents/mL, and 115±15 μM (n=9), respectively at a dose-dependent manner.
More importantly, the inhibited of colorectal cancer cells by whole extract and Ind without causing toxicity for post-confluent differentiated cells.
In chemical analysis, Ind was found to account for ∼80% of the effect of the whole extract. Ind did cause oxidative stress in proliferating Caco-2 cells.
Furthermore, Ind was found to act as a de-methylation of the tumor suppressor p16(INK4a) gene promoter, in the activation of cell cycle arrest in the G2/M-phase in the tested cell line.
More precisely, Ind kills cancer cells by decreasing hyper-phosphorylated associated with cell cycle division and promoting hypo-phosphorylated associated with cell cycle arrest without alternating the cell division enzyme cyclin-dependent kinase 4 (CD4).
Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-proliferative and pro-apoptotic activity of whole extract and isolated indicaxanthin from Opuntia ficus-indica associated with re-activation of the onco-suppressor p16(INK4a) gene in human colorectal carcinoma (Caco-2) cells by Naselli F1, Tesoriere L1, Caradonna F1, Bellavia D1, Attanzio A1, Gentile C1, Livrea MA. (PubMed)
Friday, September 20, 2019
Green Tea in Alleviated Symptoms, Onset, Recurrence and Treatment of Gout
Green tea may have a therapeutic and positive effect in reduced onset and treatment of gout and recurrent gout, some scientists suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Gout is a condition of recurrently inflammatory arthritis characterized by a red, tender, hot, and swollen joint caused by overexpression of purine in the body.
According to the study, green tea and its bioactive compound Epigallo catechin-O-gallate (EGCG) may be considered as a putative curative drug for various diseases of gout, through its properties in reduced vascular endothelial growth factor receptor 2 (VEGFR2) in response to vascular endothelial growth factor signal (VGFG) for formation of gout through expression of levels of uric acid.
The study also emphasized that green tea with high levels of antioxidant and function in stimulated production of natural antioxidant in the body may also be used to reduce symptoms of recurrently inflammatory arthritis and inflammatory arthritis such as gout, through inhibiting the oxidative stress in induced production of inflammatory cytokines to facilitate symptoms of inflammation.
The above differentiation was supported by the study of the effect of EGCG on monosodium urate monohydrate (MSU)-induced inflammation and cryopyrin (NLRP3 inflammasome) activation in C57BL/6 mice received a subcutaneous injection or oral gavage of EGCG before the intraperitoneal injection of MSU.
Truly, the application green tea EGCG decreased expression of gouty arthritis caused by the injection of MSU-induced neutrophil infiltration with function to initiate inflammation in the acute phase of infection and IL-1β secretion, in response and resistance to pathogens, but can also exacerbate damage during chronic disease and acute tissue injury.
The injection of green EGCG also decreased MSU-triggered neutrophil cytosolic factor 1, in the activated inflammatory response to optimize healing and reduce injury to the body but the proteins have been found to cause severe damage to the infectious site and NLRP3 protein expression in initiated systematic inflammatory expression.
Moreover, the effect of green tea in protection against gout occurrence also limited pro-inflammatory mediator secretion interleukin 1 beta (IL1β), a mediator of inflammation, in response to acute-phase infection, interleukin 6 (IL-6) produced by large amount at sites of acute and chronic inflammation, monocyte chemoattractant protein-1 in regulated monocytes, memory T cells, and dendritic cells to the sites of inflammation, and serum amyloid A, the serum was found to increase substantially in patient of chronic inflammatory disease. without limiting the function of the mediators in protect the infectious site against pathogens invasion.
More profoundly, the efficacy of green tea in reduced recurrent gout also extended to suppress NLRP3 inflammasome in stimulated caspase-1 in promoted secretion of others proinflammatory cytokines activation.
Dr. Jhang JJ, the lead author said, "EGCG treatment ameliorates MSU-induced inflammation, suggesting that EGCGexerts anti-inflammatory effect against MSU-induced acute gout attack."
Additionally, to the above study, the University of Pretoria suggested that polyphenols extracted from green tea also exhibited antioxidant effect in reduced pronounce of oxidative stress by their antioxidant properties.
Catechin (C) (Ki = 303.95, uncompetitive), epicatechin (EC) (Ki = 20.48, mixed), epigallocatechin (EGC) (Ki = 10.66, mixed), epicatechin gallate (ECg) (Ki = 2.86, mixed) and epigallocatechin gallate (EGCg) (Ki = 0.76, competitive) were found to have similar efficacy as allopurinol (Ki = 0.30, mixed), the drug used to inhibit the levels of xanthine oxidase (XO) in gout patients, through reduced reactive oxygen species in initiated oxidative stress in induction of inflammatory symptoms.
Taken together, green tea and its bioactive polyphenols may be considered as a functional food for reduced onset and combined with conventional medicine for the treatment of gout without inducing any adverse effects.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Multiple actions of EGCG, the main component of green tea].[Article in French] by L'Allemain G1.(PubMed)
(2) Epigallocatechin gallate inhibits urate crystals-induced peritoneal inflammation in C57BL/6 mice by Jhang JJ1, Lu CC1, Yen GC2.(PubMed)
(3) Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis) by Aucamp J1, Gaspar A, Hara Y, Apostolides Z.(PubMed)
(4) Beneficial Properties of Phytochemicals on NLRP3 Inflammasome-Mediated Gout and Complication by Jhang JJ1, Lin JH1, Yen GC1.(PubMed)
(5) Association and interaction effect between VEGF receptor-2 (VEGFR-2) gene polymorphisms and dietary pattern on blood uric acid in Malays and Indians by Roseline YW1, Shidoji Y1, Hon WM2, Masaki M1.(PubMed)
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Gout is a condition of recurrently inflammatory arthritis characterized by a red, tender, hot, and swollen joint caused by overexpression of purine in the body.
According to the study, green tea and its bioactive compound Epigallo catechin-O-gallate (EGCG) may be considered as a putative curative drug for various diseases of gout, through its properties in reduced vascular endothelial growth factor receptor 2 (VEGFR2) in response to vascular endothelial growth factor signal (VGFG) for formation of gout through expression of levels of uric acid.
The study also emphasized that green tea with high levels of antioxidant and function in stimulated production of natural antioxidant in the body may also be used to reduce symptoms of recurrently inflammatory arthritis and inflammatory arthritis such as gout, through inhibiting the oxidative stress in induced production of inflammatory cytokines to facilitate symptoms of inflammation.
The above differentiation was supported by the study of the effect of EGCG on monosodium urate monohydrate (MSU)-induced inflammation and cryopyrin (NLRP3 inflammasome) activation in C57BL/6 mice received a subcutaneous injection or oral gavage of EGCG before the intraperitoneal injection of MSU.
Truly, the application green tea EGCG decreased expression of gouty arthritis caused by the injection of MSU-induced neutrophil infiltration with function to initiate inflammation in the acute phase of infection and IL-1β secretion, in response and resistance to pathogens, but can also exacerbate damage during chronic disease and acute tissue injury.
The injection of green EGCG also decreased MSU-triggered neutrophil cytosolic factor 1, in the activated inflammatory response to optimize healing and reduce injury to the body but the proteins have been found to cause severe damage to the infectious site and NLRP3 protein expression in initiated systematic inflammatory expression.
Moreover, the effect of green tea in protection against gout occurrence also limited pro-inflammatory mediator secretion interleukin 1 beta (IL1β), a mediator of inflammation, in response to acute-phase infection, interleukin 6 (IL-6) produced by large amount at sites of acute and chronic inflammation, monocyte chemoattractant protein-1 in regulated monocytes, memory T cells, and dendritic cells to the sites of inflammation, and serum amyloid A, the serum was found to increase substantially in patient of chronic inflammatory disease. without limiting the function of the mediators in protect the infectious site against pathogens invasion.
More profoundly, the efficacy of green tea in reduced recurrent gout also extended to suppress NLRP3 inflammasome in stimulated caspase-1 in promoted secretion of others proinflammatory cytokines activation.
Dr. Jhang JJ, the lead author said, "EGCG treatment ameliorates MSU-induced inflammation, suggesting that EGCGexerts anti-inflammatory effect against MSU-induced acute gout attack."
Additionally, to the above study, the University of Pretoria suggested that polyphenols extracted from green tea also exhibited antioxidant effect in reduced pronounce of oxidative stress by their antioxidant properties.
Catechin (C) (Ki = 303.95, uncompetitive), epicatechin (EC) (Ki = 20.48, mixed), epigallocatechin (EGC) (Ki = 10.66, mixed), epicatechin gallate (ECg) (Ki = 2.86, mixed) and epigallocatechin gallate (EGCg) (Ki = 0.76, competitive) were found to have similar efficacy as allopurinol (Ki = 0.30, mixed), the drug used to inhibit the levels of xanthine oxidase (XO) in gout patients, through reduced reactive oxygen species in initiated oxidative stress in induction of inflammatory symptoms.
Taken together, green tea and its bioactive polyphenols may be considered as a functional food for reduced onset and combined with conventional medicine for the treatment of gout without inducing any adverse effects.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Multiple actions of EGCG, the main component of green tea].[Article in French] by L'Allemain G1.(PubMed)
(2) Epigallocatechin gallate inhibits urate crystals-induced peritoneal inflammation in C57BL/6 mice by Jhang JJ1, Lu CC1, Yen GC2.(PubMed)
(3) Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis) by Aucamp J1, Gaspar A, Hara Y, Apostolides Z.(PubMed)
(4) Beneficial Properties of Phytochemicals on NLRP3 Inflammasome-Mediated Gout and Complication by Jhang JJ1, Lin JH1, Yen GC1.(PubMed)
(5) Association and interaction effect between VEGF receptor-2 (VEGFR-2) gene polymorphisms and dietary pattern on blood uric acid in Malays and Indians by Roseline YW1, Shidoji Y1, Hon WM2, Masaki M1.(PubMed)
Thursday, September 19, 2019
Green tea and its Bioactive Pophenol EGCG in Attenuated Oxidative Stress in Facilitated Fibromyalgia
Green tea may have a therapeutic and positive effect in reduced risk, progression, and treatment of
fibromyalgia caused by oxidative stress, some scientists suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain affecting over 10 million (3.6% of the population) people in the US alone.
According to the study in review of literature of the frequency and pattern of complementary and alternative medicine (CAM) of 289(95%) patients who completed the survey (263 women and 26 men) between February 2003 and July 2003, green tea was recommended at 24% for treatment of fibromyalgia (FM).
In other words, in herbal medicine, green tea is considered to have certain effect in reduced symptoms and treatment for such syndrome.
Some evidence in medical literature suggested that overproduction of ROS in the induction of oxidative stress may have a strong implication in the pathophysiology of FM.
In the investigation of the effect of green tea epigallocatechin-3-gallate (EGCG) in protection of oxidative stress to cardiac cells cultured in the conditions of control, 400 μM H2O2 exposure for 30 min with and/or without 10 to 20 μM EGCG pre-treatment, researchers at the National Tsing Hua University found that treatment of green tea in H(2)O(2) group demonstrated a significant reduction of levels of reactive oxygen species through its antioxidant and its ability in induced production of natural antioxidant presented in the cardiac cells in compared to overexpression of ROS in H2O2 treatment group without injection of EGCG.
Also, application of green tea reduced levels of cytosolic Ca2+ overload in the H(2)O(2) group in induced oxidative stress in experiment cell apoptosis through improved antioxidant protein.
Interestingly, EGCG inhibited the ameliorated H(2)O(2) expression in increased glycolytic protein in response to the degree of oxidative stress in the cultured cells and α-enolase, a key glycolytic enzyme on the surface of several cell types in the contribution of impaired glycolytic activity through oxidative and nitrative stress.
Additionally, green tea EGCG also decreased levels of peroxiredoxin-4, an antioxidant with function in protection against oxidative stress by detoxifying peroxides and mitochondrial proteins with function of redox reactions of oxidative phosphorylation.
After taking into account of other confounders, researchers suggested that ingestion of green tea EGCG inhibited the damage of H(2)O(2) group through inhibition of the downstream signaling for Akt in expression glucose oxidation and cell apoptosis in cellular processes, and loss of phosphorylation of GSK-3β and cyclin D1 depletion in facilitated oxidative stress.
These result postulated that green tea EGCG exerted the similar inhibited the effect of those of GSK-3β inhibitor (SB 216763) in significantly improved H(2)O(2)-induced suppression on cell viability, phosphorylation of pAkt (S473) and pGSK-3β (S9), and level of cyclin D1 in cells.
The above differentiation was supported by the study conducted by the Universidad de Sevilla, in evaluated some evidence of green tea in reduced oxidative stress in facilitated pathophysiology of FM in initiated signs and symptoms of muscular alteration and mitochondrial dysfunction.
Truly, in primary rat model, administration of green tea EGCG in different concentrations for 24 h before being exposed to hydrogen peroxide (H(2)O(2)) for 2 h to induce oxidative stress, researchers found that pretreatment with 10, 25, and 50 µM EGCG significantly inhibited the expression of H2O2 in reduced substantial decrease in cell viability.
Further analysis also showed that green EGCG application dose of 50 µM ameliorated the proportion of propidium iodide (PI)-positive cells increased in cultures caused by H(2)O(2) injection, thus reducing H(2)O(2) in induced cell death.
Taken together, green tea and its bioactive polyphenols EGCG may be considered as a functional food in reduced risk, progression, and treatment of fibromyalgia caused by overexpression of oxidative stress. However, the intake of green tea supplement should be taken with extreme care as acute liver toxicity has been reported in numbers of medical literature.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Use of complementary and alternative medical therapies by patients referred to a fibromyalgiatreatment program at a tertiary care center by Wahner-Roedler DL1, Elkin PL, Vincent A, Thompson JM, Oh TH, Loehrer LL, Mandrekar JN, Bauer BA.(PubMed)
(2) Oxidative stress and mitochondrial dysfunction in fibromyalgia by Cordero MD1, de Miguel M, Carmona-López I, Bonal P, Campa F, Moreno-Fernández AM(PubMed)Molecular identification for epigallocatechin-3-gallate-mediated antioxidant intervention on the H2O2-induced oxidative stress in H9c2 rat cardiomyoblasts by Chen WC, Hsieh SR, Chiu CH, Hsu BD1, Liou YM.(PubMed)
(3) Molecular identification for epigallocatechin-3-gallate-mediated antioxidant intervention on the H2O2-induced oxidative stress in H9c2 rat cardiomyoblasts by Chen WC, Hsieh SR, Chiu CH, Hsu BD1, Liou YM.(PubMed)
Lycopene Inhibits Skin Cancer Cells Spreading in Vitro
Skin cancer is a medical condition associated with irregular cell growth in the skin tissues.
Most cases of skin cancer start in the cells on the surface of the outermost inner lining tissue before penetrating into deeper layers.
After growing in size at the advanced stage, the cells of the tumor may travel a distance away to infect other healthy tissue and organs through blood and fluids circulation.
Most common secondary metastasis of skin cancer is breast, lung, and colon.
Believe it or not, more people are diagnosed with skin cancer each year in the U.S. than all other cancers combined. As of today, there are 58 million American are living with skin cancer.
Approximately, 1 in 5 Americans will develop skin cancer by the age of 70.
If you have experienced some of the symptoms such as a sore that doesn't heal or comes back after healing, a pale white or yellow flat areas that look like scars, raised and scaly red patches, small, smooth and shiny lumps that are pearly white, pink or red, a pink growth with raised edges and indents in the center and a growth that has small blood vessels on the surface of the skin, you may be on the early stage of skin cancer, please check with your doctor immediately.
The 5-year survival of among all people with melanoma of the skin is 92% compared to 100% of the localized skin cancer.
Out of many prevalent factors that cause skin cancer, some researchers suggested exposure to UVB are one most risk associated with skin cancer onset in the US.
Dr. Calzavara-Pinton P, the lead scientist said, "BCC is much more strongly related to measures of intermittent ultraviolet exposure (particularly those of childhood or adolescence) than to measures of cumulative exposure".
And, " In contrast, SCC is more strongly related to constant or cumulative sun exposure. Photobiological studies have clarified that sunlight and UVB radiation are complete carcinogens for AK and SCC although the relationship with UVA exposure is much less known".
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
In the urgency to find a natural compound for the treatment of skin cancer without side effects, researchers evaluated the effect of lycopene, a kind of carotenoid inhibitory function on skin tumor cell migration.
In the human sSCC cell line COLO-16 selected to the study, administration of lycopene inhibited the cell proliferation and migration of COLO-16 cells without affecting the normal keratinocytes.
Furthermore, the inhibitory activity was found by exhibiting Zonula occludens (ZO)-1, inhibition of ZO-1 expression and its failure to accumulate at cell junctions (ZO-1 and claudin-1) have been found to induce cancer progression.
In other words, lycopene inhibited the SCC cell line COLO-16 proliferation by enhancing the expression of the tight junction complexes that regulate the permeability of epithelial against cancer cells.
Additionally, cell cycle division proteins (JNK and ERK ) in the induction of mitogen associated with the decreasing levels of ZO-1 and claudin-1 were also inhibited by the injection of lycopene.
More precisely, lycopene inhibited the progression of human sSCC cell line COLO-16 by reducing the proteins involved in promoting cell cycle division and increasing cancer cell permeability and autophagy,
Based on the findings researchers said, "This study indicates that lycopene might be a useful chemopreventive agent against cSCC".
Taken altogether, lycopene may be considered supplements for the prevention and treatment of skin cancer, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene upregulates ZO-1 and downregulates claudin-1 through autophagy inhibition in the human cutaneous squamous cell carcinoma cell line COLO-16 by Bi S1,2, Li L1, Gu H1, Li M1, Xu S1, Bu W1, Zhang M1, Zhou Z2, Chen X. (PubMed)
(2) Suppressive effects of lycopene and β-carotene on the viability of the human esophageal squamous carcinoma cell line EC109 by Ngoc NB1,2, Lv P1,3, Zhao WE1. (PubMed)
Most cases of skin cancer start in the cells on the surface of the outermost inner lining tissue before penetrating into deeper layers.
After growing in size at the advanced stage, the cells of the tumor may travel a distance away to infect other healthy tissue and organs through blood and fluids circulation.
Most common secondary metastasis of skin cancer is breast, lung, and colon.
Believe it or not, more people are diagnosed with skin cancer each year in the U.S. than all other cancers combined. As of today, there are 58 million American are living with skin cancer.
Approximately, 1 in 5 Americans will develop skin cancer by the age of 70.
If you have experienced some of the symptoms such as a sore that doesn't heal or comes back after healing, a pale white or yellow flat areas that look like scars, raised and scaly red patches, small, smooth and shiny lumps that are pearly white, pink or red, a pink growth with raised edges and indents in the center and a growth that has small blood vessels on the surface of the skin, you may be on the early stage of skin cancer, please check with your doctor immediately.
The 5-year survival of among all people with melanoma of the skin is 92% compared to 100% of the localized skin cancer.
Out of many prevalent factors that cause skin cancer, some researchers suggested exposure to UVB are one most risk associated with skin cancer onset in the US.
Dr. Calzavara-Pinton P, the lead scientist said, "BCC is much more strongly related to measures of intermittent ultraviolet exposure (particularly those of childhood or adolescence) than to measures of cumulative exposure".
And, " In contrast, SCC is more strongly related to constant or cumulative sun exposure. Photobiological studies have clarified that sunlight and UVB radiation are complete carcinogens for AK and SCC although the relationship with UVA exposure is much less known".
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
In the urgency to find a natural compound for the treatment of skin cancer without side effects, researchers evaluated the effect of lycopene, a kind of carotenoid inhibitory function on skin tumor cell migration.
In the human sSCC cell line COLO-16 selected to the study, administration of lycopene inhibited the cell proliferation and migration of COLO-16 cells without affecting the normal keratinocytes.
Furthermore, the inhibitory activity was found by exhibiting Zonula occludens (ZO)-1, inhibition of ZO-1 expression and its failure to accumulate at cell junctions (ZO-1 and claudin-1) have been found to induce cancer progression.
In other words, lycopene inhibited the SCC cell line COLO-16 proliferation by enhancing the expression of the tight junction complexes that regulate the permeability of epithelial against cancer cells.
Additionally, cell cycle division proteins (JNK and ERK ) in the induction of mitogen associated with the decreasing levels of ZO-1 and claudin-1 were also inhibited by the injection of lycopene.
More precisely, lycopene inhibited the progression of human sSCC cell line COLO-16 by reducing the proteins involved in promoting cell cycle division and increasing cancer cell permeability and autophagy,
Based on the findings researchers said, "This study indicates that lycopene might be a useful chemopreventive agent against cSCC".
Taken altogether, lycopene may be considered supplements for the prevention and treatment of skin cancer, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene upregulates ZO-1 and downregulates claudin-1 through autophagy inhibition in the human cutaneous squamous cell carcinoma cell line COLO-16 by Bi S1,2, Li L1, Gu H1, Li M1, Xu S1, Bu W1, Zhang M1, Zhou Z2, Chen X. (PubMed)
(2) Suppressive effects of lycopene and β-carotene on the viability of the human esophageal squamous carcinoma cell line EC109 by Ngoc NB1,2, Lv P1,3, Zhao WE1. (PubMed)
Wednesday, September 18, 2019
Healthy Food Cranberry, the Best in the Promotion of Oral Health
Oral health is a process or activity that protect the oral cavity against diseases by regular brushing of the teeth and cleaning between the teeth.
Gingivitis or gingival inflammation is one of the most common conditions of oral inflammation of the gum caused by overexpression of plaques accumulated on your teeth that irritate the gingiva. Over times, the gum of infected person has become swollen and bleed easily.
In severe cases, the condition can lead to periodontal disease, inducing tooth decay or loss of the tooth.
Most of the cases of gingivitis are associated with poor hygiene, particularly in people who smoke.
Gingivitis can be reversed by following a good oral health habit, including brushing at least twice a day, flossing daily and getting regular dental checkups.
Other causes of the oral problem are poor diet and hygiene, trauma, stress, alcohol use, and use of illegal substances.
However, chronic diseases also are found to induce poor oral health, including diabetes.
Most common symptoms of gingivitis including swollen gums with dusky red or dark red color and bleeding easily when brush or floss, particularly breath-breath.
According to the statistics provided by the CDC, smoking is an important cause of severe gum disease in the US.
Some researchers suggested that long-term oral infection can place the patients at risk of certain chronic disease.
Dr. Xiaojing Li, and colleagues wrote, "Recently, it has been recognized that oral infection, especially periodontitis, may affect the course and pathogenesis of a number of systemic diseases, such as cardiovascular disease, bacterial pneumonia, diabetes mellitus, and low birth weight".
And, "Periodontitis as a major oral infection may affect the host's susceptibility to systemic disease in three ways: by shared risk factors; subgingival biofilms acting as reservoirs of gram-negative bacteria; and the periodontium acting as a reservoir of inflammatory mediators".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of oral disease, researchers examined the effect of cranberry extracts on oral health, including dental caries and protection against periodontitis.
Cranberry fraction enriched in high molecular weight polyphenols from the A non-dialysable extract showed to inhibit cariogenic and periodontal pathogenic bacteria.
Diseases associated with oral inflammatory response and enzymes that degrade the extracellular matrix was also reduced upon the application of cranberry fraction.
Furthermore, according to tested differentiation, Cranberry components found in the extract also inhibited acid production, attachment, and biofilm formation by Streptococcus mutans.
Glucan-binding proteins associated with dental caries pathogen, extracellular enzymes secreted by the cell involved in a bacterial trait, and bacterial hydrophobicity were also affected by cranberry components.
In periodontal diseases, the cranberry fraction also exerted similarly aforementioned effects such as the host inflammatory responses, production, and activity of enzymes.
The findings strongly suggested that cranberry components found in cranberry worked synergistically, for the prevention and/or treatment of oral diseases, particularly in those of high molecular weight bioactive molecules.
Taken altogether, cranberry may be considered a remedy for the promotion of oral health, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential oral health benefits of cranberry by Bodet C1, Grenier D, Chandad F, Ofek I, Steinberg D, Weiss EI. (PubMed)
(2) Characterization of non-dialyzable constituents from cranberry juice that inhibit adhesion, co-aggregation and biofilm formation by oral bacteria by Neto CC1, Penndorf KA, Feldman M, Meron-Sudai S, Zakay-Rones Z, Steinberg D, Fridman M, Kashman Y, Ginsburg I, Ofek I, Weiss E. (PubMed)
(3) Systemic Diseases Caused by Oral Infection by Xiaojing Li,1,* Kristin M. Kolltveit,1 Leif Tronstad,2 and Ingar Olsen. (PMC)
Gingivitis or gingival inflammation is one of the most common conditions of oral inflammation of the gum caused by overexpression of plaques accumulated on your teeth that irritate the gingiva. Over times, the gum of infected person has become swollen and bleed easily.
In severe cases, the condition can lead to periodontal disease, inducing tooth decay or loss of the tooth.
Most of the cases of gingivitis are associated with poor hygiene, particularly in people who smoke.
Gingivitis can be reversed by following a good oral health habit, including brushing at least twice a day, flossing daily and getting regular dental checkups.
Other causes of the oral problem are poor diet and hygiene, trauma, stress, alcohol use, and use of illegal substances.
However, chronic diseases also are found to induce poor oral health, including diabetes.
Most common symptoms of gingivitis including swollen gums with dusky red or dark red color and bleeding easily when brush or floss, particularly breath-breath.
According to the statistics provided by the CDC, smoking is an important cause of severe gum disease in the US.
Some researchers suggested that long-term oral infection can place the patients at risk of certain chronic disease.
Dr. Xiaojing Li, and colleagues wrote, "Recently, it has been recognized that oral infection, especially periodontitis, may affect the course and pathogenesis of a number of systemic diseases, such as cardiovascular disease, bacterial pneumonia, diabetes mellitus, and low birth weight".
And, "Periodontitis as a major oral infection may affect the host's susceptibility to systemic disease in three ways: by shared risk factors; subgingival biofilms acting as reservoirs of gram-negative bacteria; and the periodontium acting as a reservoir of inflammatory mediators".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of oral disease, researchers examined the effect of cranberry extracts on oral health, including dental caries and protection against periodontitis.
Cranberry fraction enriched in high molecular weight polyphenols from the A non-dialysable extract showed to inhibit cariogenic and periodontal pathogenic bacteria.
Diseases associated with oral inflammatory response and enzymes that degrade the extracellular matrix was also reduced upon the application of cranberry fraction.
Furthermore, according to tested differentiation, Cranberry components found in the extract also inhibited acid production, attachment, and biofilm formation by Streptococcus mutans.
Glucan-binding proteins associated with dental caries pathogen, extracellular enzymes secreted by the cell involved in a bacterial trait, and bacterial hydrophobicity were also affected by cranberry components.
In periodontal diseases, the cranberry fraction also exerted similarly aforementioned effects such as the host inflammatory responses, production, and activity of enzymes.
The findings strongly suggested that cranberry components found in cranberry worked synergistically, for the prevention and/or treatment of oral diseases, particularly in those of high molecular weight bioactive molecules.
Taken altogether, cranberry may be considered a remedy for the promotion of oral health, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential oral health benefits of cranberry by Bodet C1, Grenier D, Chandad F, Ofek I, Steinberg D, Weiss EI. (PubMed)
(2) Characterization of non-dialyzable constituents from cranberry juice that inhibit adhesion, co-aggregation and biofilm formation by oral bacteria by Neto CC1, Penndorf KA, Feldman M, Meron-Sudai S, Zakay-Rones Z, Steinberg D, Fridman M, Kashman Y, Ginsburg I, Ofek I, Weiss E. (PubMed)
(3) Systemic Diseases Caused by Oral Infection by Xiaojing Li,1,* Kristin M. Kolltveit,1 Leif Tronstad,2 and Ingar Olsen. (PMC)
Collard Greens Inhibits the Fat Accumulation in Obese Patients
Obesity is a chronic condition characterized by excess body fat has accumulated over time. People with a BMI of over 30 is considered obese.
Similarly, overweight is a condition of excess body weight relative to height. People with a BMI ranged from 25 to 29.9 is considered overweight.
According to the statistics, 68% of the American population is either overweight or obese. Obesity has been found to induce adverse effects nearly every system of the human body, leading to increased risk of numerous diseases, including diabetes and cardiovascular disease.
Furthermore, the rate of obesity in the US and Canada continues to climb at an alarming rate, leading to significant burdens to the country economy and health care system.
Epidemiologically, most common symptoms of obesity are breathlessness, increased sweating, inability to cope with physical activity, feeling very tired every day, back and joint pains, low confidence, and self-esteem and feeling isolation
According to the CDC, most common complications associated with obesity are coronary heart disease, stroke, type 2 diabetes, cancer of breast, colon, endometrial, gallbladder, kidney, and liver and sleep apnea.
Currently, there is no effective treatment of the disease. However, some researchers suggested that combat the powerful environmental factors that influence eating and physical activity may be the best approach to reduce the risk of obesity.
Bariatric surgery is used as an option for management that causes a reduction in the amount of food you are or a reduction in the absorption of calories from the food you eat, or both.
The surgery has been proposed to patients with extreme obesity (BMI of 40 or higher) due to weight-induced a serious weight-related health problem, such as diabetes or high blood pressure.
Furthermore, this type of surgery has posed a serious risk of many patients if the commitment of making lifelong changes in eating and exercise habits cannot be followed through.
Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.
With an aim to find a natural food for the prevention and treatment of obesity, researchers examined the effect of sulforaphane found abundantly in collard greens.
In a high-fat diet (HFD)-induced obesity in C57BL/6N mice which were fed a normal diet (ND), HFD or HFD plus 0.1% sulforaphane (SFN) for 6 weeks, researchers found that SFN administration not only attenuated HFD-induced visceral adiposity that stored around a number of important internal organs such as the liver, pancreas and intestines, adipocyte hypertrophy associated with an enlargement of adipose tissue but also ameliorated fat accumulation in the liver.
Furthermore, SFN decreased the elevated levels of serum total cholesterol and leptin, and liver triglyceride in HFD-SFN-fed mice compared to HFD-fed mice.
SFN also inhibited the expression of a gene associated with the promotion of inflammation in the adipose tissue of HFD-SFN mice and increased the adiponectin function in regulating glucose levels and fatty acid breakdown.
Moreover, reductase expression associated with the production of cholesterol was decreased and an antibody associated with fatty acid utilization was increased in lycopene treat group compared with HFD-fed mice.
Taken altogether, collard green processed abundantly SFN may be considered supplements for the prevention and treatment of obesity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential effects of sulforaphane to fight obesity by Martins T1, Colaço B1,2, Venâncio C1,2, Pires MJ1,3, Oliveira PA1,3, Rosa E1, Antunes LM. (PubMed)
(2) Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice by Kyeong-Mi Choi, Youn-Sun Lee, Wonkyun Kima, Seung Jung Kimb, Kyong-Oh Shina, Ji-YeonYuc, Mi Kyeong Lee, Yong-Moon Lee, Jin Tae Honga, Yeo-PyoYuna, Hwan-SooYooa. (Science Direct)
Similarly, overweight is a condition of excess body weight relative to height. People with a BMI ranged from 25 to 29.9 is considered overweight.
According to the statistics, 68% of the American population is either overweight or obese. Obesity has been found to induce adverse effects nearly every system of the human body, leading to increased risk of numerous diseases, including diabetes and cardiovascular disease.
Furthermore, the rate of obesity in the US and Canada continues to climb at an alarming rate, leading to significant burdens to the country economy and health care system.
Epidemiologically, most common symptoms of obesity are breathlessness, increased sweating, inability to cope with physical activity, feeling very tired every day, back and joint pains, low confidence, and self-esteem and feeling isolation
According to the CDC, most common complications associated with obesity are coronary heart disease, stroke, type 2 diabetes, cancer of breast, colon, endometrial, gallbladder, kidney, and liver and sleep apnea.
Currently, there is no effective treatment of the disease. However, some researchers suggested that combat the powerful environmental factors that influence eating and physical activity may be the best approach to reduce the risk of obesity.
Bariatric surgery is used as an option for management that causes a reduction in the amount of food you are or a reduction in the absorption of calories from the food you eat, or both.
The surgery has been proposed to patients with extreme obesity (BMI of 40 or higher) due to weight-induced a serious weight-related health problem, such as diabetes or high blood pressure.
Furthermore, this type of surgery has posed a serious risk of many patients if the commitment of making lifelong changes in eating and exercise habits cannot be followed through.
Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.
With an aim to find a natural food for the prevention and treatment of obesity, researchers examined the effect of sulforaphane found abundantly in collard greens.
In a high-fat diet (HFD)-induced obesity in C57BL/6N mice which were fed a normal diet (ND), HFD or HFD plus 0.1% sulforaphane (SFN) for 6 weeks, researchers found that SFN administration not only attenuated HFD-induced visceral adiposity that stored around a number of important internal organs such as the liver, pancreas and intestines, adipocyte hypertrophy associated with an enlargement of adipose tissue but also ameliorated fat accumulation in the liver.
Furthermore, SFN decreased the elevated levels of serum total cholesterol and leptin, and liver triglyceride in HFD-SFN-fed mice compared to HFD-fed mice.
SFN also inhibited the expression of a gene associated with the promotion of inflammation in the adipose tissue of HFD-SFN mice and increased the adiponectin function in regulating glucose levels and fatty acid breakdown.
Moreover, reductase expression associated with the production of cholesterol was decreased and an antibody associated with fatty acid utilization was increased in lycopene treat group compared with HFD-fed mice.
Taken altogether, collard green processed abundantly SFN may be considered supplements for the prevention and treatment of obesity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential effects of sulforaphane to fight obesity by Martins T1, Colaço B1,2, Venâncio C1,2, Pires MJ1,3, Oliveira PA1,3, Rosa E1, Antunes LM. (PubMed)
(2) Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice by Kyeong-Mi Choi, Youn-Sun Lee, Wonkyun Kima, Seung Jung Kimb, Kyong-Oh Shina, Ji-YeonYuc, Mi Kyeong Lee, Yong-Moon Lee, Jin Tae Honga, Yeo-PyoYuna, Hwan-SooYooa. (Science Direct)
Tuesday, September 17, 2019
Herbal Bilberry, the Best in the Prevention and treatment of Type 2 Diabetes
On seeking natural therapy with no side effects, scientists may have a whole berry for the treatment of type 2 diabetes, according to studies.
Type 2 diabetes is a medical condition caused by not enough insulin entering the bloodstream to convert blood glucose into energy. Insulin resistance is a hallmark of patients with the disease.
Insulin is a hormone with a function to regulate the movement of sugar into your cells. In other words, insulin converts sugar to energy to fuel the body needs.
Most cases of type 2 diabetes is a result of not enough insulin produced by the pancreas due to reduced numbers of healthy beta cells or the insulin produced was not used properly due to the clogged up of the insulin receptor sites.
Type 2 diabetes is an acquired disease in adulthood. In the Western world, most cases of type 2 diabetes are associated with obesity induced by a long-term poor diet and lack of exercise.
Truly enough, over 68% of the population in the US are either overweight or obese.
According to the statistics in the US, in 2015, 30.3 million Americans or 9.4 percent of the U.S. population and another 84.1 million had confirmed diabetes and prediabetes, respectively.
Sadly, the majority of people with prediabetes don't know they had it.
Therefore, losing weight, eating well and moderate exercise daily can help to manage the disease against the onset of hyperglycemia, a major cause of the diabetic complication.
People with type 2 diabetes who can not manage the disease through weight loss, healthy diet and exercise are commonly treated with medications or insulin therapy.
Please make sure you know all the side effects if you are currently taking any form of therapies for diabetic treatment.
Most common symptoms of type 2 diabetes depending on the severity of the stages include increased thirst, frequent urination, unintended weight loss, and fatigue,
In severe cases, patients may also experience symptoms wound that does heal, blurred vision and frequent infections and areas of darkened skin.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
On finding potential ingredients from the treatment of type 2 diabetes, researchers examined the bilberry content of anthocyanins and polyphenols which have been proven to process antidiabetic activity in several studies.
Injection of anthocyanins and polyphenols exhibited an increase in insulin secretion (anthocyanin pelargonidin), reduction of insulin resistance (anthocyanin cyanidin-3-glucoside), and glucose resorption from the GIT (polyphenols) and enhancement of beta-cells regeneration associated with the diabetics.
In the examination of the single ingredient anthocyanins, researchers found the compounds also contribute to the improvement of the lipid spectrum compared to that of acarbose and atorvastatin, according to many preclinical and clinical studies.
Furthermore, the compound derivatives anthocyanin cyanidin-3-galactoside also have antioxidant, anti-inflammatory and cardioprotective activities.
In order to reveal more information about bilberry antidiabetic effects, researchers at the joint study led by the University of Eastern Finland differentiated the serum hippuric acid changes after intake of bilberry.
In a total of 47 individuals with features of the metabolic syndrome, randomly assigned to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12).comapred to from fasting serum samples at baseline and after an 8-week intervention, researchers showed that fasting serum hippuric acid increased significantly (3.5-fold) only in the BB group and correlated with changes in fasting plasma glucose concentration and insulin secretion.
These results suggested bilberry anti-diabetic property not only confirms the Finnish Diabetes Prevention Study but also improves glycemic control and pancreas β-cell function which is reduced in patients with type 2 diabetes.
Dr. the lead scientist wrote after taking into account co and confounders in the final report, "Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function".
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the treatment of type 2 diabetes with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes by de Mello VD1, Lankinen MA1, Lindström J2, Puupponen-Pimiä R3, Laaksonen DE4, Pihlajamäki J1,5, Lehtonen M6,7, Uusitupa M1,8, Tuomilehto J2,9,10, Kolehmainen M1, Törrönen R1, Hanhineva K. (PubMed)
(2) [Effectiveness of phytotherapy in supportive treatment of type 2 diabetes mellitusBillberry (Vaccinium myrtillus)].[Article in Czech] by Koupý D, Kotolová H, Kučerová J. (PubMed)
Type 2 diabetes is a medical condition caused by not enough insulin entering the bloodstream to convert blood glucose into energy. Insulin resistance is a hallmark of patients with the disease.
Insulin is a hormone with a function to regulate the movement of sugar into your cells. In other words, insulin converts sugar to energy to fuel the body needs.
Most cases of type 2 diabetes is a result of not enough insulin produced by the pancreas due to reduced numbers of healthy beta cells or the insulin produced was not used properly due to the clogged up of the insulin receptor sites.
Type 2 diabetes is an acquired disease in adulthood. In the Western world, most cases of type 2 diabetes are associated with obesity induced by a long-term poor diet and lack of exercise.
Truly enough, over 68% of the population in the US are either overweight or obese.
According to the statistics in the US, in 2015, 30.3 million Americans or 9.4 percent of the U.S. population and another 84.1 million had confirmed diabetes and prediabetes, respectively.
Sadly, the majority of people with prediabetes don't know they had it.
Therefore, losing weight, eating well and moderate exercise daily can help to manage the disease against the onset of hyperglycemia, a major cause of the diabetic complication.
People with type 2 diabetes who can not manage the disease through weight loss, healthy diet and exercise are commonly treated with medications or insulin therapy.
Please make sure you know all the side effects if you are currently taking any form of therapies for diabetic treatment.
Most common symptoms of type 2 diabetes depending on the severity of the stages include increased thirst, frequent urination, unintended weight loss, and fatigue,
In severe cases, patients may also experience symptoms wound that does heal, blurred vision and frequent infections and areas of darkened skin.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
On finding potential ingredients from the treatment of type 2 diabetes, researchers examined the bilberry content of anthocyanins and polyphenols which have been proven to process antidiabetic activity in several studies.
Injection of anthocyanins and polyphenols exhibited an increase in insulin secretion (anthocyanin pelargonidin), reduction of insulin resistance (anthocyanin cyanidin-3-glucoside), and glucose resorption from the GIT (polyphenols) and enhancement of beta-cells regeneration associated with the diabetics.
In the examination of the single ingredient anthocyanins, researchers found the compounds also contribute to the improvement of the lipid spectrum compared to that of acarbose and atorvastatin, according to many preclinical and clinical studies.
Furthermore, the compound derivatives anthocyanin cyanidin-3-galactoside also have antioxidant, anti-inflammatory and cardioprotective activities.
In order to reveal more information about bilberry antidiabetic effects, researchers at the joint study led by the University of Eastern Finland differentiated the serum hippuric acid changes after intake of bilberry.
In a total of 47 individuals with features of the metabolic syndrome, randomly assigned to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12).comapred to from fasting serum samples at baseline and after an 8-week intervention, researchers showed that fasting serum hippuric acid increased significantly (3.5-fold) only in the BB group and correlated with changes in fasting plasma glucose concentration and insulin secretion.
These results suggested bilberry anti-diabetic property not only confirms the Finnish Diabetes Prevention Study but also improves glycemic control and pancreas β-cell function which is reduced in patients with type 2 diabetes.
Dr. the lead scientist wrote after taking into account co and confounders in the final report, "Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function".
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the treatment of type 2 diabetes with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes by de Mello VD1, Lankinen MA1, Lindström J2, Puupponen-Pimiä R3, Laaksonen DE4, Pihlajamäki J1,5, Lehtonen M6,7, Uusitupa M1,8, Tuomilehto J2,9,10, Kolehmainen M1, Törrönen R1, Hanhineva K. (PubMed)
(2) [Effectiveness of phytotherapy in supportive treatment of type 2 diabetes mellitusBillberry (Vaccinium myrtillus)].[Article in Czech] by Koupý D, Kotolová H, Kučerová J. (PubMed)
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