Green tea and Its Bioactive Polyphenols in Protection of Cartilage Inside The Joint in Patients of Arthritis

Green tea may have a therapeutic and positive effect in the protection of the cartilage against the degeneration of arthritis in the joint, some scientists suggested.

Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.

Cartilage is a connected tissue, rubber-like padding between the joint of the bone with function to protect against bones rubbing against each other at the endpoints.

In the study of adolescent male Wistar rats 12-week exposure to Cd and Pb (7mg Cd and 50mg Pb in 1kg of the diet randomly assigned to 12 to each group, as positive control received without Cd, Pb and teas, a negative control group received Cd and Pb, and groups supplemented additionally with green (GT), black (BT), red (RT), and white tea (WT), application of tea significant inhibited the decreased levels of the geometric(shape) and densitometric(density) parameters and total thickness of articular cartilage caused by Cd and Pb in compared to the negative control group.

Tea injection group also displayed a huge improvement in mechanical endurance, growth plate thickness, and trabecular histomorphometry depending on the tea type.

Due to the limitation of the study, dr. Tomaszewska E, the lead researcher said, " It is difficult to indicate which tea has the best protective effects on bone and hyaline cartilage against heavy metal action".
Some scientists insisted that green tea with bioactive epigallocatechin-3-gallate, a green tea polyphenol, may be the one was contributed to the cartilage protection against various types of influence.

Application of green tea EGCG in drinking water of mice was found to prevent collagen-induced arthritis through inhibiting the production of certain pro-inflammatory factors in association of damage of collagen such as tumor necrosis factor-alpha (TNFα), a cell-signaling cytokine with pro-inflammatory involvement in systemic inflammation and cyclooxygenase-2, an enzyme in response to inflammation and pain.


In EGCG treatment of human chondrocytes derived from OA cartilage, the application inhibited and modulated IL-1β cytokines in induced activity and expression of cyclooxygenase-2 through its immune and inflammatory signaling and production of nitric oxide in the contribution of T lymphocyte dysfunction. and prostaglandin E2 in promotion of inflammation in chondrocytes.

According to the study, the inhibition of IL-1β by EGCG in human chondrocytes was also associated with its inhibitory effects on the activation of the nuclear translocation of NF-κB in the expression of proinflammatory activity.

Dr. Santosh K Katiya, the lead author, after taking into account of other co-founders said, "These data thus provide a mechanistic link in the prevention of arthritis responses as well as potential therapeutic value for EGCG/GTPs inhibiting cartilage resorption in arthritic joints".

Truly, in investigated the effects of catechins found in green tea on cartilage extracellular matrix components using bovine nasal and metacarpophalangeal cartilage as well as human non diseased, osteoarthritis and rheumatoid cartilage cultured with and without reagents known to accelerate cartilage matrix breakdown in vitro, researchers found that catechins, containing gallate ester, were most effective in inhibited proteoglycan and type II collagen breakdown without inducing adverse effects.

These results suggested that some green tea catechins may have a significant effect in protected or delayed against cartilage reduction and joint damage through the protection of chondrocytes.

Dr. Adcocks C, the lead author said, "green tea may be prophylactic for arthritis and may benefit the arthritis patient by reducing inflammation and slowing cartilage breakdown".

Taken together, green tea with bioactive polyphenols may be considered as a functional food for reduced or delayed progression of cartilage damage against type II collagen degradation and used the combination with standard medicine for the treatment of cartilage inside the joints in arthritis patients.



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Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alteration in bone geometric and mechanical properties, histomorphometrical parameters of trabecular bone, articular cartilage, and growth plate in adolescent rats after chronic co-exposure to cadmium and lead in the case of supplementation with green, black, red and white tea by Tomaszewska E1, Dobrowolski P2, Winiarska-Mieczan A3, Kwiecień M3, Tomczyk A4, Muszyński S5, Radzki R4.(PubMed)
(2) Green tea: a new option for the prevention or control of osteoarthritis by Santosh K Katiyar1,2 and Chander Raman(PMC)
(3) Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilageproteoglycan and type II collagen degradation in vitro by Adcocks C1, Collin P, Buttle DJ.(PubMed)

Herbal Artichoke, the Potential Anti Mesothelioma Remedy, According to Researchers

Mesothelioma is a type of cancer that develops from the thin layer of tissue known as the mesothelium.

Most cases of mesothelioma are found on the lining of the lungs and chest wall, compared to other organs. Pleural mesothelioma is a cancer of the pleural lining of the lung.


Exposure to asbestos which has been banned is one of the most common causes of the disease. Some researchers suggested that inhaling asbestos can cause mesothelioma in many ways, including
* Induced chronic low-grade inflammation of mesothelial cells as the immune system can not completely drive out the fibers that cause damage to the lung, leading to the compromise.

* Long-term exposure of the asbestos can suppress the genes associated with limited cell cycle division and tumor suppression

* Long-term exposure are also found to alter the cell DNA, leading to cancer.

According to statistic, 2000 to 3,000 people are diagnosed with mesothelioma each year in the United States. The asbestos risk of pleural mesothelioma is in the range of 2 to 10 percent.

Most cases of malignant mesothelioma are closely associated with past occupational exposure.
However, asbestos is found persistently in our natural and built environments.

Besides most common cancer symptoms, patients with pleural mesothelioma at the advanced stage may also experience symptoms of dry cough or wheezing, shortness of breath (dyspnea), respiratory complications and pain in the chest or abdomen.


Some patients may also develop pleural effusion (fluid around the lungs), fever or night sweats, fatigue, and muscle weakness


Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.

In the concern of the malignant pleural mesothelioma, a poorly treated neoplasia by conventional medicine, arising from the pleural mesothelial lining, researchers examined leaf extract of Cynara scolymus in vitro and in vivo.

The study included tMSTO-211H, MPP-89 and NCI-H28 mesothelioma cell lines and untransformed mesothelial cells HMC, treated with increasing concentrations (ranging from 3 to 200 μg/ml) of artichoke leaf extract for 72 hrs.

Injection of the leaf extract not only inhibited strongly the cell proliferation but also affected the migration and tumor engraftment in the mesothelioma cell lines.

More precisely, MSTO-211H cells treated with the artichoke extract showed a change in the cellular morphology both in a short-term assay, compared to more resistant more resistance in the HMC cells.

In MSTO-211H, MPP-89 and NCI-H28 cells, injection of artichoke leaf extract inhibited the formation of cancer cell colony.

Astonishingly, dietary feeding with Cynara scolymus leaf extract showed a similar inhibition against the growth of mesothelioma xenografted tumors comparable to those of pemetrexed.


Where pemetrexed is a chemo medicine used for the treatment of cancer, including mesothelioma.


Dr. Claudio Pulito and colleagues suggested, "leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma".


Taken altogether, artichoke leaf extract may be considered a functioning remedy for the prevention and treatment of mesothelioma, pending to the confirmation of large sample size and multicenter human study.





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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion by Pulito C1, Mori F1, Sacconi A2, Casadei L3, Ferraiuolo M2, Valerio MC3, Santoro R1, Goeman F2, Maidecchi A4, Mattoli L4, Manetti C3, Di Agostino S2, Muti P5, Blandino G2,5, Strano S. (PMC)

Green Tea and its Bioactive Polyphenol Epigallocatechin 3-gallate (EGCG) in Alleviated Symptoms, Reduced Risk, Progression and Treatment of Arthritis

Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of arthritis, some scientists suggested.

Arthritis is a chronic condition characterized by painful inflammation and stiffness of the joints.

According to statistic, arthritis is the common autoimmune disorder affected over 50 million worldwide.

According to the College of Pharmacy, green tea epigallocatechin 3-gallate (EGCG) in preclinical studies displayed a significant effect in the treatment of arthritic disease.

In vitro, the application of green tea extract EGCG demonstrated activities in cartilage-preserving and chondroprotective action through reduced expression of proinflammatory IL-1β, TNFα, and IL-6
and modulated extracellular matrix (ECM) turnover induced changes of the biomechanical environment of chondrocytes and accelerate the degradation of cartilage as well as driving the progression of the disease in the presence of inflammation.

Normal extracellular matrix (ECM) is a composed collagen type II with function to provide tensile support for the tissue.

Further analysis in the expression of proinflammatory factors researchers found that the overexpression of proinflammatory cytokines IL-1 and IL-6 were associated correlatively in knee joints in arthritis and inhibition of IL-1 and IL-6 by green tea EGCG IL-1 showed to reduce joint damage.

Some researchers also suggested that Interleukin 1 (IL-1) is a crucial mediator of the inflammatory response, playing an important part in the body's natural responses and the development of pathological conditions leading to chronic inflammation.

In the expression of tumor necrosis factor (TNF), tumor necrosis factor-alpha(TNFα, cachexin, or cachectin), application of green tea inhibited the levels of TNFα in the induction of synovial fibroblast cytotoxicity.

Interestingly, in the study to evaluate the possible effects of the administration of green tea extract on the oxidative state of the liver and brain of adjuvant-induced arthritic rats, researchers indicated that green tea daily doses of 250 mg kg(-1) (59.8 mg catechins per kg) for 23 days displays a strong effect in decreased symptoms of arthritis by ameliorated diminutions in protein and lipid damage in liver, brain and plasma, through antioxidant effect in reduced levels of ROS in stimulated free radical chain reaction to initiate production of pro-inflammatory cytokines to precipitate chronic diseases.

Rats treated with green tea EGCG also showed a significant improvement in restored natural antioxidant glutathione (GSH) and protein thiol levels produced by the body, by exhibiting the activities of the antioxidant enzymes.

Moreover, green tea injection also normalized the activity of glucose 6-phosphate dehydrogenase, which is increased in the liver of arthritic patients and considered as a risk factor for the development of arthritis. Increased activity glucose 6-phosphate dehydrogenase was associated to reactive oxygen species (ROS) generated in oxidative metabolism in inflicted damage on all classes of macromolecules.

Additional differentiation of green tea EGCG immunomodulatory effects and mechanisms on experimental arthritis induced by collagen-induced arthritis (CIA) in mice in compared to control received phosphate-buffered saline (PBS), researchers found that application of green tea EGCG at dose of 10 mg/kg demonstrated a strong effect in ameliorated clinical symptoms and reduced histological scores in arthritic mice, through modulated the immune activity by induced overexpression of the Nrf-2 antioxidant pathway, a major mechanism in the cellular defense against oxidative or electrophilic stress through detoxication and elimination.

EGCG also ameliorated experimental arthritis in mice by eliciting indoleamine-2,3-dioxygenase (IDO) through inhibition of pro-inflammatory cytokine interferon-gamma, astrocytes and microglia in facilitated production of dendritic cells (DCs) in the activation of the immune system to attack the dendritic cell located on the surface on the joint tissue.

Application of the EGCG also increased frequencies of T regs with a dominant role in the suppression of autoimmune pathology.

Some researchers suggested that increased Treg number and/or function in model systems may have a significant effect on both prevented and reversed arthritis disease.

Taken together, green tea with abundant bioactive polyphenol epigallocatechin 3-gallate (EGCG) may be considered as a functional food for alleviated symptoms, reduced risk, and progression and treatment of arthritis.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM.(PubMed)
(2) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S1,3, Kwon SR1,4, Vanarsa K1,3, Kim HY4, Davis LS#1, Mohan C(PubMed)
(3) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Ahmed S1.(PubMed)
(4) Is IL-1 a good therapeutic target in the treatment of arthritis? by Burger D1, Dayer JM, Palmer G, Gabay C.(PubMed)

Healthy Food Turmeric, a Natural Prevention and Treatment of Ulcerative Colitis (UC)<, Researchers Say

Ulcerative colitis is a type of inflammatory bowel disease induced chronic inflammation and ulcers (sores) in the digestive tract.

The disease affects the colon and the rectum, leading to bloody diarrhea accompanied by symptoms of belly pain, not feeling hungry, fatigue, weight loss, dehydration.

Some patients may also experience symptoms of joint pain or soreness and sudden urges to empty the colon right away.

The UC is caused by the immune system mistakenly attacks the cell of the colon, leading to low-grade inflammation.

According to the statistic, in the US, approximately, 1.6 million Americans are living with inflammatory bowel disease, including 907,000 people with ulcerative colitis.

More precisely, the risk of people diagnosed with ulcerative colitis per 100,000 person-years is between 2 and 14.

Conventionally, the treatment of UC is focused on reduced symptoms and prevent the fare up. In some cases, surgery may be necessary if the medication fails.

The are many prevalent factors associated with UC, including aging, ethnicity, and family. However, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong implication in inducing the rise of ulcerative colitis.

Dr. Mitsuro Chiba, the lead scientist wrote, " Diets rich in animal protein (risk factor) and deficient in dietary fiber (preventive factor) are characteristic of westernized diets in affluent societies. Recent research shows that westernized diets are associated with reduced gut microbial diversity (dysbiosis), which may result in increased susceptibility to IBD and other common chronic diseases".

And, "Plant-based diets rich in dietary fiber are associated with increased microbial diversity. Recent reports on IBD therapy that replaced westernized diets with plant-based diets achieved far better outcomes than those previously reported in the literature. We believe that westernized diet-associated gut dysbiosis is the most ubiquitous environmental factor in IBD".


The results strongly link the risk of IBD in people who follow the Western diet.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound for the treatment of ulcerative colitis, researchers conducted a systematical review and meta-analyze on the efficacy of oral curcumin administration as adjuvant therapy of UC. MEDLINE, Cochrane/CENTRAL, ClinicalTrials.gov, WHO-ICT.

According to the findings, With the M-H method, treatment with curcumin was significantly superior to placebo but not in the intention-to-treat (ITT) analysis.

However, with the more accurate B-B method, both analyses were found to be insignificant.

In other words, oral curcumin administration was not superior to placebo in attaining remission in patients with UC.

In other to clarify the effect of curcumin on UC, a joint study led by the Bassett Medical Center was conducted by searching the databases of medical literature in the MEDLINE, Pubmed, and Embase through December 2017.

According to the results of 3 randomized controlled trials including 142 patients included in the study, clinical improvement, endoscopic remission, and improvement rate also trended higher in the curcumin group compared to placebo.
In other words, higher clinical remission rates when curcumin was used in combination with mesalamine to achieve remission in patients with UC.


Dr. Iqb al U, the lead scientist wrote, "Curcumin, due to its cost-effectiveness and safer side effect profile, can decrease the healthcare burden and morbidity associated with this relapsing and remitting disease".

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of ulcerative colitis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Oral Adjuvant Curcumin Therapy for Attaining Clinical Remission in Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Grammatikopoulou MG1,2,3, Gkiouras K4,5, Theodoridis X6,7, Asteriou E8, Forbes A9, Bogdanos DP. (PubMed)
(2) Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis by Iqbal U1, Anwar H2, Quadri AA. (PubMed)
(3) Westernized Diet is the Most Ubiquitous Environmental Factor in Inflammatory Bowel Disease by Mitsuro Chiba, MD, PhD1; Kunio Nakane, MD, PhD1; Masafumi Komatsu, MD, Ph.D. (the Permanente Journal)

Green Tea and Its Bioactive Polyphenols That Inhibit Risk and Treatment of Candidiasis

Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of Candidiasis, some scientists suggested.

Candida albicans are members of a large group of microorganism whose cells contain complex structures enclosed within the membranes, including yeast, fungi, and mold, living among the gut flora in the human mouth and gastrointestinal tract.

Overgrowth of candida is also known as candidiasis, affecting the skin, including the skin of the vagina, the penis, and the mouth.


In severe cases, the yeast overgrowth also causes infection of the blood and internal organs such as the liver, lung, and spleen.

Some researchers suggested that candidiasis can weaken the immune function, therefore, the infection has a strongly negative implication in people with damaged immune diseases, such as AIDS. Particularly, people are treated with chemotherapy for cancer.


Unhealthy diet and lifestyle are associated with increased risk of candida overgrowth. The article, "Lifestyle Habits That Lead to Yeast Infections" By Gina Roberts-Grey and Reviewed by Rosalyn Carson-DeWitt, MD, wrote, ".....modifying some every day habits can alleviate yeast infection symptoms and reduce the odds you will have a vaginal infection" and “Many women don’t realize they have the ability to reduce their chances of developing a yeast infection”(4).


Symptoms of candidiasis are totally depending on the infected locations. Vaginal yeast infection can cause the discharge of a thick, white, clumpy (cottage-cheese-like) substance with odor, leading to itches, urinary burning sensation, and painful sexual intercourse.

In nail, the yeast infection can cause painful, red, swollen around the nail.


In the mouth, the infection may induce cracked, red at the corners of the mouth.


In the investigation of The effectiveness of the synergistic herbal-based composition of purified catechins with fluconazole, amphotericin B and copper sulphate against Candida albicans (MTCC 3017) and Candida glabrata (MTCC 3019), researchers found that* According to the time-kill assay, catechins demonstrated twice efficacy in the same at minimum inhibitory concentration in compared to antimycotics.


*Additional copper sulfate injection increased anticandidal efficacy of synergistic combinations by 0.4% to 6.63%.

* The combination significantly induced cytotoxicity with high percentage viability (≥91.4% to≥100%) of Vero cell line without inducing harm to nearby healthy cells.

Base on these results, Dr. Ning Y, the lead scientist said, "(the) present evaluated synergistic composition can confer promising anticandidal efficacy" and (However, These result) requires further investigation of safety and translational guidelines for effective and safer green tea-based potent therapeutic drug".

Further evaluation of green tea bioactive polyphenol epigallocatechin gallate (EGCG) in inhibited the growth of Candida albicans planktonic cells and enhanced the antifungal activity of antimycotics of Candida albicans, Candida parapsilosis, Candida tropicalis, Candida glabrata, Candida kefyr, and Candida krusei, the Nihon University School of Dentistry at Matsudo filed the reports as follows

* Green tea EGCG exerted a synergistic activity with miconazole, fluconazole or amphotericin B against most test planktonic and biofilm cells of Candida species (FIC≤0.5).

* All biofilm cells were significantly more resistant to EGCG and antimycotics (20-3200 times higher) in compared with their planktonic counterparts.


These results suggested, "EGCG enhances the antifungal effects of miconazole, fluconazole, and amphotericin B. Combined treatment with EGCG may lower the dosages of antimycotics, thus preventing adverse effects and the emergence of drug-resistant oral Candida species".

Interestingly, the assessment of antifungal activity of catechin pH dependently displayed that

* The concentration of epigallocatechin gallate (EGCg) causing 90% growth inhibition of tested strains of C. albicans was 2000 mg/L at pH 6.0, 500-1000 mg/L at pH 6.5 and 15.6-250 mg/L at pH 7.0.

* Among catechins, pyrogallol catechin showed stronger antifungal activity against C. albicans than catechol catechin.


* The addition of 6.25-25 or 3.12-12.5 mg/L EGCG to amphotericin B 0.125 or 0.25 mg/L (below MIC) at pH 7.0 resulted in enhancement, respectively, of the antifungal effect of amphotericin B against amphotericin B-susceptible or -resistant C. albicans.

* Combined treatment with 3.12-12.5 mg/L EGCg plus amphotericin B 0.5 mg/L (below MIC) markedly decreased the growth of amphotericin B-resistant C. albicans.

* Fluconazole-susceptible C. albicans was treated with 25-50 mg/L EGCg and fluconazole 0.125-0.25 mg/L (below MIC), its growth was inhibited by 93.0%-99.4% compared with its growth in the presence of fluconazole alone.


* The combined use of 12.5 mg/L EGCg and fluconazole 10-50 mg/L (below MIC) inhibited the growth of fluconazole-resistant C. albicans by 98.5%-99.7%.


The findings suggested that green tea extract and its bioactive polyphenols may be used alone to reduced risk and treatment or secondary therapy in enhanced standard medicine for the treatment of Candidiasis.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.caAuthor Biography

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Anticandidal synergistic activity of green tea catechins, antimycotics and copper sulphate as a mean of combinational drug therapy against candidiasis by Anand J1, Rai N2(PubMed)
(2) Synergistic effects of tea catechin epigallocatechin gallate and antimycotics against oral Candida species by Ning Y1, Ling J2, Wu CD3.(PubMed)
(3) Multiple effects of green tea catechin on the antifungal activity of antimycotics against Candida albicans by Hirasawa M1, Takada K.(PubMed)
(4) Lifestyle Habits That Lead to Yeast Infections By Gina Roberts-Grey, Reviewed by Rosalyn Carson-DeWitt, MD

Turmeric, the Anti Hyperlipidemia Herbal Remedy

Hyperlipidemia or high blood cholesterol is a condition that causes abnormally high levels of lipids in the blood.

Cholesterol plays an essential role in moderate amount in orchestrating the production of steroid hormone and vitamin D, building strong cell walls and aiding the digestive system in absorbing nutrients and fluids.

Cholesterol can either be produced by the liver or consumed form the food sources. There are 2 types of cholesterol
*The high-density lipoprotein is also known as "good" cholesterol processes a function to return cholesterol to the liver.

* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in moderate amount.

In a healthy individual, the bad cholesterol is returned to the liver. However, overexpression of "bad" cholesterol due to the consumption of a high-fat diet and reduced levels of "good" cholesterol can induce an unhealthy ratio of bad and good cholesterol, leading to bad cholesterol remaining in the bloodstream, a cause of hyperlipidemia.


Overexpression of bad cholesterol has been found to facilitate the plaque accumulated in the arterial wall, a major cause of heart disease and stroke.

According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL in the US.

Conventionally, hyperlipidemia is treated by simvastatin, lovastatin, atorvastatin, and rosuvastatin. However, holistically, by a change of diet and daily moderate exercise, you may control the condition without medication.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the treatment of hyperlipidemia, researchers investigated the effects of curcumin on hyperlipidemia and hepatic steatosis in high-fructose-fed Wistar rats.

Rat groups selected to the study were divided into four groups with 10 rats in each group with two groups fed with standard rodent diet with or without plus curcumin (200 mg/kg body weight) and the other two with 60% high-fructose diet with or without curcumin (200 mg/kg body weight)for 10 weeks.

According to the results of differentiation, co-administration of curcumin reduced body weight, liver weight, adipose weight, plasma levels of TAG, VLDL-C associated with the onset of hyperlipidemia compared to the untreated group.

Additionally, curcumin also increased the levels of lipid ratios in favors of the HDL-C by increasing the levels of HDL-C (28.4 ± 4.5 mg/dL) in fructose-fed rats compared to standard rodent diet rats.

The protein expression of LXR-α (43%) and SREBP1c (59%) associated with inflammation and activation of cholesterol in the liver were also decreased by the injection curcumin.

More importantly, curcumin suppressed the expression of lipogenic enzymes associated with lipid metabolism and genes involved in cholesterol production in rats fed with a high-fructose diet.

Based on the findings, researchers said, "Curcumin prevented the high-fructose induced hyperlipidemia and hepatic steatosis".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats by Maithilikarpagaselvi N1, Sridhar MG1, Swaminathan RP2, Sripradha R1, Badhe B. (PubMed)
(2) Effects of curcumin on HDL functionality by Ganjali S1, Blesso CN2, Banach M3, Pirro M4, Majeed M5, Sahebkar A. (PubMed)

Cucumber's Cucurbitacin B (CuB) Might Process Anti Diabetes Potency

Diabetes is a medical condition caused by not insufficient insulin entering the bloodstream.

In other words, diabetes is a condition associated with the inability of the body to use insulin properly.

Most cases of insulin insufficiency in the bloodstream in diabetes are either caused by the gradual died-off of the pancreas beta cells or insulin receptors clogged-up by fat and cholesterol.

Hallmarks of diabetes are hyperglycemia and insulin resistance.

According to the statistics, in 2017, 7.3% of Canadians aged 12 and older (roughly 2.3 million people) reported being diagnosed with diabetes

Most common causes of diabetes are
* Metabolic syndrome
Metabolic syndrome is a cluster of conditions including high blood pressure, cholesterol, and glucose
associated with an increased risk of diabetes.

* Gestational diabetes
High blood glucose of pregnant women has been found to increase the risk of diabetes in later life.

* Prediabetes
Most cases of prediabetes are caused by unhealthy diets with high saturated fat, smoking, and excessive alcohol drinking. Prediabetes is a high-risk state for diabetes, especially in patients who remain with prediabetes despite intensive lifestyle intervention.

* Damage to the Pancreas causes the gradual and irreversible loss of beta cells that reduce the production of insulin

* Influenza a viruses
Influenza A virus is a common cause of pancreatitis in naturally and experimentally infected animals.
However, recently, researchers found that influenza virus infection may play a role as a causative agent of pancreatitis and diabetes in humans.

* * Head trauma
Head trauma is considered a possible cause of central diabetes insipidus with symptoms of failure to concentrate urine, an increase in urine specific gravity.

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound which processes anti-diabetes property, researchers investigated the effect of different fractions of Cucumis prophetarum on antidiabetic and antioxidant activity.

The study was carried out to examine the anti-diabetes and antioxidants of the different doses of aqueous crude extract (CE) of C. prophetarum fruits fractionated into water-soluble fraction 1 (F1), chloroform fraction 2 (F2), basic fraction 3 (F3), and neutral fraction 4 (F4) by acid-base extraction,

Based on the chemical analysis,
* F1 exhibited effective antidiabetic activity with an IC50 value of 20.6 and 59.9 µg/mL.

* According to α-amylase assay, the anti-diabetes activity was found in the decreasing order of CE > F4 > F3 > F2.

* According to the DPPH assay, F1 (IC50 = 73 µg/mL) showed better reducing ability than CE >F4 >F2 > F3 (IC50 = 78-272 µg/mL

* Furthermore, according to the SO and metal chelation assays, F1 showed the highest activity anti-diabetes at the IC50 = 101 and 147 µg/mL.
These results strongly suggested that F1 possesses a potent antidiabetic compared to other fractions, in vitro.

In other words, all ingredients in cucumbers work synergistically to exhibit the anti-diabetes activity compared to a single compound.

Taken altogether, cucumber may be used for the treatment of diabetes, pending to the confirmation of the larger sample size and multicenter human study.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antidiabetic and antioxidant potency evaluation of different fractions obtained from Cucumis prophetarum fruit by Gawli K1, Lakshmidevi N. (PubMed)
(2) Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling by Kim KH1,2, Lee IS1,2, Park JY1,2, Kim Y1,2, An EJ1,2, Jang HJ. (PubMed)
(3) Diabetes – The Causes by Kyle J. Norton