Herbal Artichoke, the Potential Anti Mesothelioma Remedy, According to Researchers

Mesothelioma is a type of cancer that develops from the thin layer of tissue known as the mesothelium.

Most cases of mesothelioma are found on the lining of the lungs and chest wall, compared to other organs. Pleural mesothelioma is a cancer of the pleural lining of the lung.


Exposure to asbestos which has been banned is one of the most common causes of the disease. Some researchers suggested that inhaling asbestos can cause mesothelioma in many ways, including
* Induced chronic low-grade inflammation of mesothelial cells as the immune system can not completely drive out the fibers that cause damage to the lung, leading to the compromise.

* Long-term exposure of the asbestos can suppress the genes associated with limited cell cycle division and tumor suppression

* Long-term exposure are also found to alter the cell DNA, leading to cancer.

According to statistic, 2000 to 3,000 people are diagnosed with mesothelioma each year in the United States. The asbestos risk of pleural mesothelioma is in the range of 2 to 10 percent.

Most cases of malignant mesothelioma are closely associated with past occupational exposure.
However, asbestos is found persistently in our natural and built environments.

Besides most common cancer symptoms, patients with pleural mesothelioma at the advanced stage may also experience symptoms of dry cough or wheezing, shortness of breath (dyspnea), respiratory complications and pain in the chest or abdomen.


Some patients may also develop pleural effusion (fluid around the lungs), fever or night sweats, fatigue, and muscle weakness


Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.

In the concern of the malignant pleural mesothelioma, a poorly treated neoplasia by conventional medicine, arising from the pleural mesothelial lining, researchers examined leaf extract of Cynara scolymus in vitro and in vivo.

The study included tMSTO-211H, MPP-89 and NCI-H28 mesothelioma cell lines and untransformed mesothelial cells HMC, treated with increasing concentrations (ranging from 3 to 200 μg/ml) of artichoke leaf extract for 72 hrs.

Injection of the leaf extract not only inhibited strongly the cell proliferation but also affected the migration and tumor engraftment in the mesothelioma cell lines.

More precisely, MSTO-211H cells treated with the artichoke extract showed a change in the cellular morphology both in a short-term assay, compared to more resistant more resistance in the HMC cells.

In MSTO-211H, MPP-89 and NCI-H28 cells, injection of artichoke leaf extract inhibited the formation of cancer cell colony.

Astonishingly, dietary feeding with Cynara scolymus leaf extract showed a similar inhibition against the growth of mesothelioma xenografted tumors comparable to those of pemetrexed.


Where pemetrexed is a chemo medicine used for the treatment of cancer, including mesothelioma.


Dr. Claudio Pulito and colleagues suggested, "leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma".


Taken altogether, artichoke leaf extract may be considered a functioning remedy for the prevention and treatment of mesothelioma, pending to the confirmation of large sample size and multicenter human study.





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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion by Pulito C1, Mori F1, Sacconi A2, Casadei L3, Ferraiuolo M2, Valerio MC3, Santoro R1, Goeman F2, Maidecchi A4, Mattoli L4, Manetti C3, Di Agostino S2, Muti P5, Blandino G2,5, Strano S. (PMC)