The Muscle is a soft tissue in the body containing protein filaments of actin and myosin that slide past one another, with a function to produce force and motion.
In other words, muscle contraction and expansion that changes both the length and the shape allow us to move and lift.
Muscle mass is the calculation of the weight of the muscles in the body in kilograms or pounds. However, other factors may also interfere with the above calculation including height, ethnicity, and fitness level.
Increased muscle mass is associated with lower fat accumulation and the ability to burn calories/energy.
Some researchers suggested, by boosting your muscle mass, you will also improve your health, including* Boosts your metabolism. Dr. Alexandra C. McPherron, the lead scientist said, "increasing skeletal muscle mass by inhibiting signaling of myostatin, a transforming growth factor β (TGFβ) family member that negatively regulates muscle growth, prevents the development of diabetes in a mouse model of lipodystrophy. Muscle-specific myostatin inhibition also prevented hyperphagia suggesting muscle may regulate food intake".
In other words, increasing muscle mass improve your body metabolism.
* Improves Bone Mass. Dr. Colletti LAand colleagues said, "additional evidence that muscle-building exercise is associated with increases in BMD at weight-bearing sites but not at on weight-bearing sites".
* Reduces fat accumulation. Dr. Silva TR, the lead scientist wrote, "Skeletal muscle mass index (SMI) was positively correlated with physical activity (r = 0.205, P = 0.038) and protein intake (r = 0.334, P = 0.001), and negatively correlated with waist circumference (r = -0.505, P < 0.001) and %body fat (r = 0.808, P < 0.001)".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent anti-aging compound, researchers examined the effects of ashwagandha root extract on muscle mass and strength in healthy young men engaged in resistance training.
The randomized, prospective, double-blind, placebo-controlled clinical study included 57 young male subjects (18-50 years old) with little experience in resistance training randomized into treatment received 300 mg of ashwagandha root extract twice daily, (29 subjects) and placebo, consumed starch placebos (28 subjects) groups.
Besides baseline measurements, both groups also underwent resistance training for 8 weeks with measurements repeated at the end of week 8.
Based on the results of measurement of the participants in both groups, compared to placebo, the treatment group showed significantly greater increases i
* In muscle strength on the bench-press exercise (Placebo: 26.4 kg vs. Ashwagandha: 46.0 kg)
* In the leg-extension exercise (Placebo: 9.8 kg) vs. Ashwagandha: 14.5 kg)
* In muscle size increase at the arms (Placebo: 5.3 cm(2) vs. Ashwagandha: 8.6 cm(2))
* In chest (Placebo: 1.4 cm vs. Ashwagandha: 3.3 cm).
Furthermore, ashwagandha treated group also had a significantly greater reduction of exercise-induced muscle damage.
Moreover, Ashwagandha treated group also showed a significantly greater increase in testosterone level (Placebo: 18.0 ng/dL Ashwagandha: 96.2 ng/dL)
More importantly, there was a significantly greater decrease in body fat percentage in treament group compared to placebo (Placebo: 1.5% vs. Ashwagandha: 3.5%).
Based on the finding, researchers wrote, "ashwagandha supplementation is associated with significant increases in muscle mass and strength and suggests that ashwagandha supplementation may be useful in conjunction with a resistance training program".
Taken altogether, Ashwagandha may be used as a supplement for the improvement of muscle mass and strength in the resistance training program, pending to the results from the large sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial by Wankhede S1, Langade D2, Joshi K3, Sinha SR4, Bhattacharyya S. (PubMed)
(2) Increasing muscle mass to improve metabolism by Alexandra C. McPherron, Tingqing Guo, Nichole D. Bond, and Oksana Gavrilova. (PMC)
(3) The effects of muscle-building exercise on bone mineral density of the radius, spine, and hip in young men by Colletti LA1, Edwards J, Gordon L, Shary J, Bell NH. (PubMed)
(4) Skeletal muscle mass is associated with higher dietary protein intake and lower body fat in postmenopausal women: a cross-sectional study by Silva TR1, Spritzer PM. (PubMed)
Sunday, September 29, 2019
How to Cure Impetigo Naturally With No Adverse Effects, US National Library of Medicine Studies Suggestions
Green tea or tea lotion may have a therapeutic and positive effect better than conventional medicine Framycetin and Cephalexin gramicidin (soframycin) in treatment of impetigo, some scientists suggested.
The disease investigation was differentiated by numbers of institutes including Baghdad University and the results of the studies were published on online literature.
You can view the abstract of studies from PubMed, by clicking any of the resources' link.
Impetigo is a skin condition caused by bacterial skin infection with symptoms of blisters and sores,
around the nose and mouth, and on the arms or legs. In some case, it may appear in the facial area.
The disease infects mostly children.
In differentiated the effect of tea lotion against impetigo infected by bacteria, researchers at the Baghdad University conducted a study with participated of a total of 104 patients, including 47 females (45.2%) and 57 males (54.8%) with ages ranged from one month to 40 years with a median of 4 years.
Patients were randomly assigned to the treatment group with green tea applied to the infected areas and control group.
According to the diagnosis from the swabbed collected from patients, and analysed by microbiology impetigo contagiosa, pure S. aureus and combination of S. aureus and Streptococcus pyogenes were presented in 94.3% and 5.7% respectively in all patients.
These results suggested that the prevalent risk of impetigo is mostly caused by the infection of S. aureus.
Application tea lotion, including green tea, demonstrated a significant effect in reduced infectious areas substantially with the successfully cured rate of 81.3% in compared to control nontreatment group.
In examining the 40 patients in control group further assigned to 2 groups received either an ointment containing Framycetin or gramicidin (soframycin), researchers found that Framycetin and cephalexin gramicidin (soframycin) exerted a potential a cure rate of only 72.2% and 78.6%, respectively.
The results suggested that tea ointment or lotion displayed a better effect in treating impetigo in compared to conventional medicine Framycetin and gramicidin (soframycin) without inducing any adverse effects.
Dr. Sharquie KE, after taking into account of other co and confounders said: "(tea lotion) demonstrated the anti-bacterial action of crude tea in vivo, against impetigo contagiosa".
In further evaluation of green tea effect in reduced prevalence of skin infection, researchers at the Oakland University William Beaumont School of Medicine Rochester showed that catechins found in green tea have shown promise for having antimicrobial effects, particular in the fractions of (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC), and (-)-epigallocatechin-3-gallate (EGCG).
Researchers continued, application of green tea bioactive catechin exhibited a variety of antimicrobial mechanisms and may be considered as a potential for preventive and therapeutic purposes.
In fact, relatively low concentrations of ECG was found to sensitize methicillin-resistant S. aureus (MRSA) clinical isolates to levels of oxacillin.
And, Catechin gallates such as ECG also showed to intercalate into phospholipid bilayers, affecting both virulence and antibiotic resistance by perturbing the function of the bacterial process of invasion.
The results may be attributed to green tea effect in reduced key processes associated with the bacterial cytoplasmic membrane.
However, further data collection on studies performed with human consumption during the course of infections, and studies on the occurrence of infections in populations that consume regular amounts of green tea will be necessary to complete the picture of its antimicrobial possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) The antibacterial activity of tea in vitro and in vivo (in patients with impetigo contagiosa).
Sharquie KE1, al-Turfi IA, al-Salloum SM.(PubMed)
(2) Antimicrobial properties of green tea catechins by Taylor PW1, Hamilton-Miller JM, Stapleton PD.(PubMed)
(3) The antimicrobial possibilities of green tea by Reygaert WC1.(PubMed)
The disease investigation was differentiated by numbers of institutes including Baghdad University and the results of the studies were published on online literature.
You can view the abstract of studies from PubMed, by clicking any of the resources' link.
Impetigo is a skin condition caused by bacterial skin infection with symptoms of blisters and sores,
around the nose and mouth, and on the arms or legs. In some case, it may appear in the facial area.
The disease infects mostly children.
In differentiated the effect of tea lotion against impetigo infected by bacteria, researchers at the Baghdad University conducted a study with participated of a total of 104 patients, including 47 females (45.2%) and 57 males (54.8%) with ages ranged from one month to 40 years with a median of 4 years.
Patients were randomly assigned to the treatment group with green tea applied to the infected areas and control group.
According to the diagnosis from the swabbed collected from patients, and analysed by microbiology impetigo contagiosa, pure S. aureus and combination of S. aureus and Streptococcus pyogenes were presented in 94.3% and 5.7% respectively in all patients.
These results suggested that the prevalent risk of impetigo is mostly caused by the infection of S. aureus.
Application tea lotion, including green tea, demonstrated a significant effect in reduced infectious areas substantially with the successfully cured rate of 81.3% in compared to control nontreatment group.
In examining the 40 patients in control group further assigned to 2 groups received either an ointment containing Framycetin or gramicidin (soframycin), researchers found that Framycetin and cephalexin gramicidin (soframycin) exerted a potential a cure rate of only 72.2% and 78.6%, respectively.
The results suggested that tea ointment or lotion displayed a better effect in treating impetigo in compared to conventional medicine Framycetin and gramicidin (soframycin) without inducing any adverse effects.
Dr. Sharquie KE, after taking into account of other co and confounders said: "(tea lotion) demonstrated the anti-bacterial action of crude tea in vivo, against impetigo contagiosa".
In further evaluation of green tea effect in reduced prevalence of skin infection, researchers at the Oakland University William Beaumont School of Medicine Rochester showed that catechins found in green tea have shown promise for having antimicrobial effects, particular in the fractions of (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC), and (-)-epigallocatechin-3-gallate (EGCG).
Researchers continued, application of green tea bioactive catechin exhibited a variety of antimicrobial mechanisms and may be considered as a potential for preventive and therapeutic purposes.
In fact, relatively low concentrations of ECG was found to sensitize methicillin-resistant S. aureus (MRSA) clinical isolates to levels of oxacillin.
And, Catechin gallates such as ECG also showed to intercalate into phospholipid bilayers, affecting both virulence and antibiotic resistance by perturbing the function of the bacterial process of invasion.
The results may be attributed to green tea effect in reduced key processes associated with the bacterial cytoplasmic membrane.
However, further data collection on studies performed with human consumption during the course of infections, and studies on the occurrence of infections in populations that consume regular amounts of green tea will be necessary to complete the picture of its antimicrobial possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) The antibacterial activity of tea in vitro and in vivo (in patients with impetigo contagiosa).
Sharquie KE1, al-Turfi IA, al-Salloum SM.(PubMed)
(2) Antimicrobial properties of green tea catechins by Taylor PW1, Hamilton-Miller JM, Stapleton PD.(PubMed)
(3) The antimicrobial possibilities of green tea by Reygaert WC1.(PubMed)
Saturday, September 28, 2019
Phytochemical Alliin, The Best Natural Antioxidants
Antioxidants are stable atoms that inhibit oxidation caused by free radicals.
Free radicals, on the other hand, are unstable atoms with an unpaired electron in the outermost ring.
Therefore, in order for them to achieve stable, free radicals are always ready to intercept or donate an electron to other stable atoms, leading to a cascade that cannot be stopped until all electrons in the outermost ring are paired or inhibited by antioxidants.
Overexpression of free radicals in the long-term can lead to oxidative stress, leading to proteins and lipids and cell damage in facilitating the onset of cardiovascular disease, diabetes, neuro diseases,... and caners.
Most cases of oxidative stress is a result of an imbalance of the ratio of the levels of free radicals and antioxidant.
Believe it or not, free radicals in a moderate amount and in the control of the presence of antioxidant are essential for the body in food and energy metabolism and blood circulation.
Dr. V. Lobo, the lead scientist in the evaluation of "Free radicals, antioxidants, and functional foods: Impact on human health". wrote, "Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. A balance between free radicals and antioxidants is necessary for proper physiological function".
And, " Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years".
The results suggested by maintaining an adequate amount of functional foods (not synthetic antioxidants) with plenty of antioxidants, oxidative stress may be preventable.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find the potential compound for the treatment of diseases associated with oxidative stress, researchers examined the antioxidant activity of bioactive compound alliin.
Compared to garlic compounds representing the four main chemical classes, alliin, allyl cysteine, allyl disulfide, and allicin, prepared by chemical synthesis or purification, researchers found that alliin showed a better-scavenged superoxide property, particularly in hydroxyl radicals compared to others compound.
Allicin, a derivative of alliin suppressed the formation of superoxide by the xanthine/xanthine oxidase system, probably via a thiol and allicin exchange mechanism in the prevention of formation of free radicals.
However, Alliin and allicin did not prevent induced microsomal lipid peroxidation.
In other words, alliin is antioxidants with the free radical scavenging property.
Dr. Chung LY said in the final report, "allyl disulfide, alliin, allicin, and allyl cysteine exhibit different patterns of antioxidant activities as protective compounds against free radical damage".
In bone resorption associated with osteoclast differentiation and fusion, alliin (S-allyl-l-cysteine sulfoxides, SACSO) displayed a significant antioxidant activity by inhibiting the osteoclastogenesis with a dose-dependent manner via blocking the (c-Fos-NFATc1) signaling pathway involved cell differentiation and fusion.
Furthermore, alliin protected the bone density by decreasing the generation of reactive oxygen species (ROS) and inhibiting the expression of (NADPH oxidase 1 (Nox1)) protein associated with elevated ROS reactive oxygen.
Taken altogether, alliin may be considered supplements for the prevention and treatment of diseases involved in oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide by Chung LY. (PubMed)
(2) Alliin Attenuated RANKL-Induced Osteoclastogenesis by Scavenging Reactive Oxygen Species through Inhibiting Nox by Chen Y1,2, Sun J3, Dou C4, Li N5, Kang F6, Wang Y7, Cao Z8, Yang X9, Dong S. (PubMed)
(3) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PubMed)
Free radicals, on the other hand, are unstable atoms with an unpaired electron in the outermost ring.
Therefore, in order for them to achieve stable, free radicals are always ready to intercept or donate an electron to other stable atoms, leading to a cascade that cannot be stopped until all electrons in the outermost ring are paired or inhibited by antioxidants.
Overexpression of free radicals in the long-term can lead to oxidative stress, leading to proteins and lipids and cell damage in facilitating the onset of cardiovascular disease, diabetes, neuro diseases,... and caners.
Most cases of oxidative stress is a result of an imbalance of the ratio of the levels of free radicals and antioxidant.
Believe it or not, free radicals in a moderate amount and in the control of the presence of antioxidant are essential for the body in food and energy metabolism and blood circulation.
Dr. V. Lobo, the lead scientist in the evaluation of "Free radicals, antioxidants, and functional foods: Impact on human health". wrote, "Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. A balance between free radicals and antioxidants is necessary for proper physiological function".
And, " Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years".
The results suggested by maintaining an adequate amount of functional foods (not synthetic antioxidants) with plenty of antioxidants, oxidative stress may be preventable.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find the potential compound for the treatment of diseases associated with oxidative stress, researchers examined the antioxidant activity of bioactive compound alliin.
Compared to garlic compounds representing the four main chemical classes, alliin, allyl cysteine, allyl disulfide, and allicin, prepared by chemical synthesis or purification, researchers found that alliin showed a better-scavenged superoxide property, particularly in hydroxyl radicals compared to others compound.
Allicin, a derivative of alliin suppressed the formation of superoxide by the xanthine/xanthine oxidase system, probably via a thiol and allicin exchange mechanism in the prevention of formation of free radicals.
However, Alliin and allicin did not prevent induced microsomal lipid peroxidation.
In other words, alliin is antioxidants with the free radical scavenging property.
Dr. Chung LY said in the final report, "allyl disulfide, alliin, allicin, and allyl cysteine exhibit different patterns of antioxidant activities as protective compounds against free radical damage".
In bone resorption associated with osteoclast differentiation and fusion, alliin (S-allyl-l-cysteine sulfoxides, SACSO) displayed a significant antioxidant activity by inhibiting the osteoclastogenesis with a dose-dependent manner via blocking the (c-Fos-NFATc1) signaling pathway involved cell differentiation and fusion.
Furthermore, alliin protected the bone density by decreasing the generation of reactive oxygen species (ROS) and inhibiting the expression of (NADPH oxidase 1 (Nox1)) protein associated with elevated ROS reactive oxygen.
Taken altogether, alliin may be considered supplements for the prevention and treatment of diseases involved in oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide by Chung LY. (PubMed)
(2) Alliin Attenuated RANKL-Induced Osteoclastogenesis by Scavenging Reactive Oxygen Species through Inhibiting Nox by Chen Y1,2, Sun J3, Dou C4, Li N5, Kang F6, Wang Y7, Cao Z8, Yang X9, Dong S. (PubMed)
(3) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PubMed)
Green Tea and its Bioactive epigallocatechin 3-gallate (EGCG) in Attenuated Risk, progression of Fibromyalgia Caused by Inflammatory Rheumatic Disorders
Green tea may have a therapeutic and positive effect in reduced onset, progression and treatment of inflammatory rheumatic disorders induced fibromyalgia, some scientists suggested.
Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.
Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people in the US alone.
The inflammatory rheumatic disorder is a condition of autoimmune diseases caused inflammatory connective tissues, joint, and vessels of the body, including rheumatoid arthritis, systemic lupus erythematosus, and vasculitis.
According to the Cairo University, as many as 15-30% of patients with classic inflammatory rheumatic disorders also have co-morbid fibromyalgia syndrome (FMS) compared to the rate of only 2% of the prevalence of FMS in the general population (2%).
These results suggested that rheumatological syndromes have a strong implication in the development of fibromyalgia syndrome (FMS) compared to other initiators such as stress.
Therefore, patients with chronic rheumatic diseases are capable of triggering condition of fibromyalgia syndrome (FMS).
Due to the highly correlated rheumatologic disease and FMS component, researchers postulated "Considerations of the FMS component in the management of rheumatologic diseases increase the likelihood of the success of the treatment" and "(prevented) FMS in misdiagnosed as an autoimmune disorder"
In the study of the effect of green tea's active ingredient, epigallocatechin 3-gallate (EGCG) in risk of inflammatory rheumatic disorders in collagen-induced arthritis (CIA) in mice, researchers found that application of green tea demonstrates a substantially marked inhibition of the inflammatory mediators cyclooxygenase (COX) -2 in converting arachidonic acid in stimulated production of proinflammatory cytokine prostaglandin H2, in catalyzation of symptoms of inflammation in the muscles.
Furthermore, green tea EGCG oral ingestion also inhibited levels of interferon-gamma in precipitated inflammation by modulating T-cells and natural killer cells activated by antigens, mitogens or alloantigens to the site of infection.
Tumor necrosis factor-alpha (TNFα) involved in systemic inflammation, one of the cytokines that make up the acute phase reaction in mice was also inhibited by injection of green tea EGCG.
These result suggested that green tea ameliorated symptoms expression of inflammatory rheumatic disorders, through attenuating production pro-inflammatory factors without reducing the healing progression of injured tissue.
The above differentiation was supported by the study of green tea extract GTE in modestly ameliorated rat adjuvant-induced arthritis.
According to researchers, a daily per-oral administration of GTE (200 mg/kg) reduced expression of RA through reduced levels of MCP-1/CCL2 in expression (which can also be treated by biological agents, such as antibodies and inhibitory peptides) of a variety of diseases characterized by mononuclear cell infiltration involved substantial biological and genetic evidence, including RA.
and GROα/CXCL1 in the recruitment of inflammatory cells in the wound healing process after injury in angiogenesis and information of granulation tissue of wounds.
Additionally, application of green tea beside attenuated the expression of proinflammatory factors, its also exhibited the production of chemokine receptors CCR-1, CCR-2, CCR-5 in reduced direct communication between the innate and adaptive immune responses in initiated the development of inflammatory responses. through inactivation of leukocytes in inflamed tissues in contribution to the pathogenesis of inflammatory and autoimmune diseases.
And CXCR1 receptor in binding to IL-8 in reduced expression some inflammatory cytokines in initiated inflammation such as epidermal growth factor (EGF) and tumor necrosis factor-α (TNF-α).
Some researchers suggested that application of green tea extract may also reduce the symptoms of arthritis through expression of IL-6 levels, as increased levels of Il-6 was associated to the presence and progression of rheumatoid arthritis (RA) found in conventional clinical and laboratory indices and MMP-2 activity in activated immune-inflammatory response through inducing production of pro-inflammatory factors.
Taken together, green tea and its bioactive compound such as EGCG may have a profound and therapeutic effect in reducing the onset, progression, and treatment of fibromyalgia induced by inflammatory rheumatic disorders through modulating the production of pro and anti-inflammatory proteins. However, the intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fibromyalgia and Rheumatic Diseases by Gheita TA*, El-Rabbat SM and Mahmoud NK(Open Access)
(2) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Salahuddin Ahmed(PMC)
Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.
Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people in the US alone.
The inflammatory rheumatic disorder is a condition of autoimmune diseases caused inflammatory connective tissues, joint, and vessels of the body, including rheumatoid arthritis, systemic lupus erythematosus, and vasculitis.
According to the Cairo University, as many as 15-30% of patients with classic inflammatory rheumatic disorders also have co-morbid fibromyalgia syndrome (FMS) compared to the rate of only 2% of the prevalence of FMS in the general population (2%).
These results suggested that rheumatological syndromes have a strong implication in the development of fibromyalgia syndrome (FMS) compared to other initiators such as stress.
Therefore, patients with chronic rheumatic diseases are capable of triggering condition of fibromyalgia syndrome (FMS).
Due to the highly correlated rheumatologic disease and FMS component, researchers postulated "Considerations of the FMS component in the management of rheumatologic diseases increase the likelihood of the success of the treatment" and "(prevented) FMS in misdiagnosed as an autoimmune disorder"
In the study of the effect of green tea's active ingredient, epigallocatechin 3-gallate (EGCG) in risk of inflammatory rheumatic disorders in collagen-induced arthritis (CIA) in mice, researchers found that application of green tea demonstrates a substantially marked inhibition of the inflammatory mediators cyclooxygenase (COX) -2 in converting arachidonic acid in stimulated production of proinflammatory cytokine prostaglandin H2, in catalyzation of symptoms of inflammation in the muscles.
Furthermore, green tea EGCG oral ingestion also inhibited levels of interferon-gamma in precipitated inflammation by modulating T-cells and natural killer cells activated by antigens, mitogens or alloantigens to the site of infection.
Tumor necrosis factor-alpha (TNFα) involved in systemic inflammation, one of the cytokines that make up the acute phase reaction in mice was also inhibited by injection of green tea EGCG.
These result suggested that green tea ameliorated symptoms expression of inflammatory rheumatic disorders, through attenuating production pro-inflammatory factors without reducing the healing progression of injured tissue.
The above differentiation was supported by the study of green tea extract GTE in modestly ameliorated rat adjuvant-induced arthritis.
According to researchers, a daily per-oral administration of GTE (200 mg/kg) reduced expression of RA through reduced levels of MCP-1/CCL2 in expression (which can also be treated by biological agents, such as antibodies and inhibitory peptides) of a variety of diseases characterized by mononuclear cell infiltration involved substantial biological and genetic evidence, including RA.
and GROα/CXCL1 in the recruitment of inflammatory cells in the wound healing process after injury in angiogenesis and information of granulation tissue of wounds.
Additionally, application of green tea beside attenuated the expression of proinflammatory factors, its also exhibited the production of chemokine receptors CCR-1, CCR-2, CCR-5 in reduced direct communication between the innate and adaptive immune responses in initiated the development of inflammatory responses. through inactivation of leukocytes in inflamed tissues in contribution to the pathogenesis of inflammatory and autoimmune diseases.
And CXCR1 receptor in binding to IL-8 in reduced expression some inflammatory cytokines in initiated inflammation such as epidermal growth factor (EGF) and tumor necrosis factor-α (TNF-α).
Some researchers suggested that application of green tea extract may also reduce the symptoms of arthritis through expression of IL-6 levels, as increased levels of Il-6 was associated to the presence and progression of rheumatoid arthritis (RA) found in conventional clinical and laboratory indices and MMP-2 activity in activated immune-inflammatory response through inducing production of pro-inflammatory factors.
Taken together, green tea and its bioactive compound such as EGCG may have a profound and therapeutic effect in reducing the onset, progression, and treatment of fibromyalgia induced by inflammatory rheumatic disorders through modulating the production of pro and anti-inflammatory proteins. However, the intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fibromyalgia and Rheumatic Diseases by Gheita TA*, El-Rabbat SM and Mahmoud NK(Open Access)
(2) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Salahuddin Ahmed(PMC)
Friday, September 27, 2019
Phytochemical Betanin, the Chemo Prevention and Treatment of Cancer
Cancer is a class of chronic disease associated with the alternation of cell DNA.
Most cases of cancer start in the cell on the surface of the inner lining of the organ tissue, before penetrating deeper into other layers to form a tumor.
Epidemiologically, most cases of cancer at the very early stage are asymptomatic. However, at the advanced stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs.
Types of secondary metastasis can be classified into
1. Local spreading, lymph vessel, blood vessel
* Local spreading as soon as the cancer cells grow to its tumor size, it will invade the nearby area.
* Spread through lymph vessel
If some cancer cells detached from the primary tumor and travel, they can grow into secondary cancer but most of the time they are trapped in the nearby lymph nodes closest to the original tumor.
* Spread through blood circulation
Similar to spread through lymph vessel, cancer cells detached from an original tumor can enter the bloodstream by slipping pass the blood vessel wall and start growing into the secondary tumor as they are trapped into some small capillaries.
2. Travel of clumps of cancer along the channels
Sometimes, cancer cells detached from the primary tumor can travel through other channels and spread to some parts of the body that are more vulnerable to become metastatic sites than others.
3. The arrival of cancer cells at a distance site
The development of the survival of cancer cells gets trapped and grow into the second tumor.
4. Angiogenesis
Angiogenesis is a process involving the growth of new blood vessels from pre-existing vessels. The secondary tumor can persuade the adjacent tissue to build blood vessels by providing it with vital nutrients and oxygen.
At this stage, the overgrowth of the tumor may also press on the nerve cells, blood vessels, and healthy tissues, leading to specific symptoms, depending to the types of tumor accompanied by the general symptoms shared by all cancers.
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In the urgency to find a potential and natural compound for the treatment of cancer with no side effects, researchers examined the effects of betanin (BET) in reducing the side effects of potent anticancer drugs e.g. doxorubicin (DOX) on the normal tissues in co-administration.
In order to overcome the incomplete oral absorption and low stability of BET that limits its application, synergistic effect of DOX@BET by a new pH-responsive nanocarrier via decoration of gelatin nanoparticles (GNPs) (methoxy poly (ethylene glycol)-poly ((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (PGNPs) was designed.
According to the triggered release ability of drugs assays, the GNPs not only controlled the release of DOX and BET with adjusting the pH of the environment but also decreased the cell viability amount of breast cancer cells (MCF-7) compared to the free form of DOX or BET.
In other words, BET combined with DOX not only enhanced the chemo drug toxicity against cancer but also reduced the side effect found in the free form of DOX.
Furthermore, in two mouse lung tumor models, researchers at the Washington University School of Medicine investigated the chemopreventive activity of betanin by oral consumption.
The experiment included vinyl carbamate (VC) and benzo(a)pyrene (B(a)P) induced lung cancer female A/J mice with lung cancer were treated with betanin in drinking water.
According to the tested assays, injection of betanin significantly decreased tumor multiplicity and tumor load induced by both carcinogens by 20% and 39% in the VC lung model, and by 46% and 65% in the B(a)P lung model, respectively.
The efficacy of betanin in both lung cancer models has attributed to the phytochemical lung tumor inhibitory effects in the induction of apoptosis and inhibition of angiogenesis.
Dr. Zhang Q, the lead scientists after taking other factors into account wrote, " Our data show that betanin significantly inhibits lung tumorigenesis in A/J mice and merits investigation as a chemopreventive agent for human lung cancer:.
Taken altogether, betanin may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of larger sample size and multicenter human study.
Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy by Amjadi S1, Hamishehkar H2, Ghorbani M. (PubMed)
(2) Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis by Zhang Q1, Pan J, Wang Y, Lubet R, You M. (PubMed)
Most cases of cancer start in the cell on the surface of the inner lining of the organ tissue, before penetrating deeper into other layers to form a tumor.
Epidemiologically, most cases of cancer at the very early stage are asymptomatic. However, at the advanced stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs.
Types of secondary metastasis can be classified into
1. Local spreading, lymph vessel, blood vessel
* Local spreading as soon as the cancer cells grow to its tumor size, it will invade the nearby area.
* Spread through lymph vessel
If some cancer cells detached from the primary tumor and travel, they can grow into secondary cancer but most of the time they are trapped in the nearby lymph nodes closest to the original tumor.
* Spread through blood circulation
Similar to spread through lymph vessel, cancer cells detached from an original tumor can enter the bloodstream by slipping pass the blood vessel wall and start growing into the secondary tumor as they are trapped into some small capillaries.
2. Travel of clumps of cancer along the channels
Sometimes, cancer cells detached from the primary tumor can travel through other channels and spread to some parts of the body that are more vulnerable to become metastatic sites than others.
3. The arrival of cancer cells at a distance site
The development of the survival of cancer cells gets trapped and grow into the second tumor.
4. Angiogenesis
Angiogenesis is a process involving the growth of new blood vessels from pre-existing vessels. The secondary tumor can persuade the adjacent tissue to build blood vessels by providing it with vital nutrients and oxygen.
At this stage, the overgrowth of the tumor may also press on the nerve cells, blood vessels, and healthy tissues, leading to specific symptoms, depending to the types of tumor accompanied by the general symptoms shared by all cancers.
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In the urgency to find a potential and natural compound for the treatment of cancer with no side effects, researchers examined the effects of betanin (BET) in reducing the side effects of potent anticancer drugs e.g. doxorubicin (DOX) on the normal tissues in co-administration.
In order to overcome the incomplete oral absorption and low stability of BET that limits its application, synergistic effect of DOX@BET by a new pH-responsive nanocarrier via decoration of gelatin nanoparticles (GNPs) (methoxy poly (ethylene glycol)-poly ((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (PGNPs) was designed.
According to the triggered release ability of drugs assays, the GNPs not only controlled the release of DOX and BET with adjusting the pH of the environment but also decreased the cell viability amount of breast cancer cells (MCF-7) compared to the free form of DOX or BET.
In other words, BET combined with DOX not only enhanced the chemo drug toxicity against cancer but also reduced the side effect found in the free form of DOX.
Furthermore, in two mouse lung tumor models, researchers at the Washington University School of Medicine investigated the chemopreventive activity of betanin by oral consumption.
The experiment included vinyl carbamate (VC) and benzo(a)pyrene (B(a)P) induced lung cancer female A/J mice with lung cancer were treated with betanin in drinking water.
According to the tested assays, injection of betanin significantly decreased tumor multiplicity and tumor load induced by both carcinogens by 20% and 39% in the VC lung model, and by 46% and 65% in the B(a)P lung model, respectively.
The efficacy of betanin in both lung cancer models has attributed to the phytochemical lung tumor inhibitory effects in the induction of apoptosis and inhibition of angiogenesis.
Dr. Zhang Q, the lead scientists after taking other factors into account wrote, " Our data show that betanin significantly inhibits lung tumorigenesis in A/J mice and merits investigation as a chemopreventive agent for human lung cancer:.
Taken altogether, betanin may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of larger sample size and multicenter human study.
Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy by Amjadi S1, Hamishehkar H2, Ghorbani M. (PubMed)
(2) Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis by Zhang Q1, Pan J, Wang Y, Lubet R, You M. (PubMed)
Green tea and Its Bioactive Polyphenols in Protection of Cartilage Inside The Joint in Patients of Arthritis
Green tea may have a therapeutic and positive effect in the protection of the cartilage against the degeneration of arthritis in the joint, some scientists suggested.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Cartilage is a connected tissue, rubber-like padding between the joint of the bone with function to protect against bones rubbing against each other at the endpoints.
In the study of adolescent male Wistar rats 12-week exposure to Cd and Pb (7mg Cd and 50mg Pb in 1kg of the diet randomly assigned to 12 to each group, as positive control received without Cd, Pb and teas, a negative control group received Cd and Pb, and groups supplemented additionally with green (GT), black (BT), red (RT), and white tea (WT), application of tea significant inhibited the decreased levels of the geometric(shape) and densitometric(density) parameters and total thickness of articular cartilage caused by Cd and Pb in compared to the negative control group.
Tea injection group also displayed a huge improvement in mechanical endurance, growth plate thickness, and trabecular histomorphometry depending on the tea type.
Due to the limitation of the study, dr. Tomaszewska E, the lead researcher said, " It is difficult to indicate which tea has the best protective effects on bone and hyaline cartilage against heavy metal action".
Some scientists insisted that green tea with bioactive epigallocatechin-3-gallate, a green tea polyphenol, may be the one was contributed to the cartilage protection against various types of influence.
Application of green tea EGCG in drinking water of mice was found to prevent collagen-induced arthritis through inhibiting the production of certain pro-inflammatory factors in association of damage of collagen such as tumor necrosis factor-alpha (TNFα), a cell-signaling cytokine with pro-inflammatory involvement in systemic inflammation and cyclooxygenase-2, an enzyme in response to inflammation and pain.
In EGCG treatment of human chondrocytes derived from OA cartilage, the application inhibited and modulated IL-1β cytokines in induced activity and expression of cyclooxygenase-2 through its immune and inflammatory signaling and production of nitric oxide in the contribution of T lymphocyte dysfunction. and prostaglandin E2 in promotion of inflammation in chondrocytes.
According to the study, the inhibition of IL-1β by EGCG in human chondrocytes was also associated with its inhibitory effects on the activation of the nuclear translocation of NF-κB in the expression of proinflammatory activity.
Dr. Santosh K Katiya, the lead author, after taking into account of other co-founders said, "These data thus provide a mechanistic link in the prevention of arthritis responses as well as potential therapeutic value for EGCG/GTPs inhibiting cartilage resorption in arthritic joints".
Truly, in investigated the effects of catechins found in green tea on cartilage extracellular matrix components using bovine nasal and metacarpophalangeal cartilage as well as human non diseased, osteoarthritis and rheumatoid cartilage cultured with and without reagents known to accelerate cartilage matrix breakdown in vitro, researchers found that catechins, containing gallate ester, were most effective in inhibited proteoglycan and type II collagen breakdown without inducing adverse effects.
These results suggested that some green tea catechins may have a significant effect in protected or delayed against cartilage reduction and joint damage through the protection of chondrocytes.
Dr. Adcocks C, the lead author said, "green tea may be prophylactic for arthritis and may benefit the arthritis patient by reducing inflammation and slowing cartilage breakdown".
Taken together, green tea with bioactive polyphenols may be considered as a functional food for reduced or delayed progression of cartilage damage against type II collagen degradation and used the combination with standard medicine for the treatment of cartilage inside the joints in arthritis patients.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Alteration in bone geometric and mechanical properties, histomorphometrical parameters of trabecular bone, articular cartilage, and growth plate in adolescent rats after chronic co-exposure to cadmium and lead in the case of supplementation with green, black, red and white tea by Tomaszewska E1, Dobrowolski P2, Winiarska-Mieczan A3, Kwiecień M3, Tomczyk A4, Muszyński S5, Radzki R4.(PubMed)
(2) Green tea: a new option for the prevention or control of osteoarthritis by Santosh K Katiyar
1,2 and Chander Raman(PMC)
(3) Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilageproteoglycan and type II collagen degradation in vitro by Adcocks C1, Collin P, Buttle DJ.(PubMed)
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Cartilage is a connected tissue, rubber-like padding between the joint of the bone with function to protect against bones rubbing against each other at the endpoints.
In the study of adolescent male Wistar rats 12-week exposure to Cd and Pb (7mg Cd and 50mg Pb in 1kg of the diet randomly assigned to 12 to each group, as positive control received without Cd, Pb and teas, a negative control group received Cd and Pb, and groups supplemented additionally with green (GT), black (BT), red (RT), and white tea (WT), application of tea significant inhibited the decreased levels of the geometric(shape) and densitometric(density) parameters and total thickness of articular cartilage caused by Cd and Pb in compared to the negative control group.
Tea injection group also displayed a huge improvement in mechanical endurance, growth plate thickness, and trabecular histomorphometry depending on the tea type.
Due to the limitation of the study, dr. Tomaszewska E, the lead researcher said, " It is difficult to indicate which tea has the best protective effects on bone and hyaline cartilage against heavy metal action".
Some scientists insisted that green tea with bioactive epigallocatechin-3-gallate, a green tea polyphenol, may be the one was contributed to the cartilage protection against various types of influence.
Application of green tea EGCG in drinking water of mice was found to prevent collagen-induced arthritis through inhibiting the production of certain pro-inflammatory factors in association of damage of collagen such as tumor necrosis factor-alpha (TNFα), a cell-signaling cytokine with pro-inflammatory involvement in systemic inflammation and cyclooxygenase-2, an enzyme in response to inflammation and pain.
In EGCG treatment of human chondrocytes derived from OA cartilage, the application inhibited and modulated IL-1β cytokines in induced activity and expression of cyclooxygenase-2 through its immune and inflammatory signaling and production of nitric oxide in the contribution of T lymphocyte dysfunction. and prostaglandin E2 in promotion of inflammation in chondrocytes.
According to the study, the inhibition of IL-1β by EGCG in human chondrocytes was also associated with its inhibitory effects on the activation of the nuclear translocation of NF-κB in the expression of proinflammatory activity.
Dr. Santosh K Katiya, the lead author, after taking into account of other co-founders said, "These data thus provide a mechanistic link in the prevention of arthritis responses as well as potential therapeutic value for EGCG/GTPs inhibiting cartilage resorption in arthritic joints".
Truly, in investigated the effects of catechins found in green tea on cartilage extracellular matrix components using bovine nasal and metacarpophalangeal cartilage as well as human non diseased, osteoarthritis and rheumatoid cartilage cultured with and without reagents known to accelerate cartilage matrix breakdown in vitro, researchers found that catechins, containing gallate ester, were most effective in inhibited proteoglycan and type II collagen breakdown without inducing adverse effects.
These results suggested that some green tea catechins may have a significant effect in protected or delayed against cartilage reduction and joint damage through the protection of chondrocytes.
Dr. Adcocks C, the lead author said, "green tea may be prophylactic for arthritis and may benefit the arthritis patient by reducing inflammation and slowing cartilage breakdown".
Taken together, green tea with bioactive polyphenols may be considered as a functional food for reduced or delayed progression of cartilage damage against type II collagen degradation and used the combination with standard medicine for the treatment of cartilage inside the joints in arthritis patients.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Alteration in bone geometric and mechanical properties, histomorphometrical parameters of trabecular bone, articular cartilage, and growth plate in adolescent rats after chronic co-exposure to cadmium and lead in the case of supplementation with green, black, red and white tea by Tomaszewska E1, Dobrowolski P2, Winiarska-Mieczan A3, Kwiecień M3, Tomczyk A4, Muszyński S5, Radzki R4.(PubMed)
(2) Green tea: a new option for the prevention or control of osteoarthritis by Santosh K Katiyar
1,2 and Chander Raman(PMC)(3) Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilageproteoglycan and type II collagen degradation in vitro by Adcocks C1, Collin P, Buttle DJ.(PubMed)
Thursday, September 26, 2019
Herbal Artichoke, the Potential Anti Mesothelioma Remedy, According to Researchers
Mesothelioma is a type of cancer that develops from the thin layer of tissue known as the mesothelium.
Most cases of mesothelioma are found on the lining of the lungs and chest wall, compared to other organs. Pleural mesothelioma is a cancer of the pleural lining of the lung.
Exposure to asbestos which has been banned is one of the most common causes of the disease. Some researchers suggested that inhaling asbestos can cause mesothelioma in many ways, including
* Induced chronic low-grade inflammation of mesothelial cells as the immune system can not completely drive out the fibers that cause damage to the lung, leading to the compromise.
* Long-term exposure of the asbestos can suppress the genes associated with limited cell cycle division and tumor suppression
* Long-term exposure are also found to alter the cell DNA, leading to cancer.
According to statistic, 2000 to 3,000 people are diagnosed with mesothelioma each year in the United States. The asbestos risk of pleural mesothelioma is in the range of 2 to 10 percent.
Most cases of malignant mesothelioma are closely associated with past occupational exposure.
However, asbestos is found persistently in our natural and built environments.
Besides most common cancer symptoms, patients with pleural mesothelioma at the advanced stage may also experience symptoms of dry cough or wheezing, shortness of breath (dyspnea), respiratory complications and pain in the chest or abdomen.
Some patients may also develop pleural effusion (fluid around the lungs), fever or night sweats, fatigue, and muscle weakness
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
In the concern of the malignant pleural mesothelioma, a poorly treated neoplasia by conventional medicine, arising from the pleural mesothelial lining, researchers examined leaf extract of Cynara scolymus in vitro and in vivo.
The study included tMSTO-211H, MPP-89 and NCI-H28 mesothelioma cell lines and untransformed mesothelial cells HMC, treated with increasing concentrations (ranging from 3 to 200 μg/ml) of artichoke leaf extract for 72 hrs.
Injection of the leaf extract not only inhibited strongly the cell proliferation but also affected the migration and tumor engraftment in the mesothelioma cell lines.
More precisely, MSTO-211H cells treated with the artichoke extract showed a change in the cellular morphology both in a short-term assay, compared to more resistant more resistance in the HMC cells.
In MSTO-211H, MPP-89 and NCI-H28 cells, injection of artichoke leaf extract inhibited the formation of cancer cell colony.
Astonishingly, dietary feeding with Cynara scolymus leaf extract showed a similar inhibition against the growth of mesothelioma xenografted tumors comparable to those of pemetrexed.
Where pemetrexed is a chemo medicine used for the treatment of cancer, including mesothelioma.
Dr. Claudio Pulito and colleagues suggested, "leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma".
Taken altogether, artichoke leaf extract may be considered a functioning remedy for the prevention and treatment of mesothelioma, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion by Pulito C1, Mori F1, Sacconi A2, Casadei L3, Ferraiuolo M2, Valerio MC3, Santoro R1, Goeman F2, Maidecchi A4, Mattoli L4, Manetti C3, Di Agostino S2, Muti P5, Blandino G2,5, Strano S. (PMC)
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