Friday, October 4, 2019

Green Tea and Its Bioactive Polyphenols in Reduced Alpha1-Antitrypsin (AAT) Deficiency in Induction of Fibromyalgia

Green tea may have a therapeutic and positive effect on the reduced onset. progression and treatment of Alpha1-Antitrypsin (AAT) deficiency in induced fibromyalgia, some scientists suggested.

Green tea is a precious drink that processed a number of health benefits and known to almost everyone in Asia and the Western world.

Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people in the US alone.

Serum of alpha1-Antitrypsin (AAT) impregnated in most body tissues circulates in our body in high concentrations with function as a broad anti-inflammatory spectrum in inhibition of enzymes of inflammatory cells, especially neutrophil elastase.

In the study of the effect of serum of alpha1-Antitrypsin (AAT) and risk of fibromyalgia (FM), researchers at the Hospital Valle del Nalón found that deficiency of AAT has been found in numbers of patients with fibromyalgia (FM) with severe hereditary.

Functional magnetic resonance imaging of these patients revealed significant greater activity in pain-sensitive areas of the brain in response to cutaneous stimuli, which may be another evidence for a physiological explanation for FM pain.

Furthermore, patients with FM also were found to consist of abnormal profiles of inflammation markers in biopsies analysis.

The results suggested that these patients may have an imbalance level of pro-inflammatory and anti-inflammatory substances, in the soft body tissues caused by alpha1-Antitrypsin (AAT) deficiency.


Due to surprising findings, Dr. Blanco LE, the lead author, after taking into account of other confounders, said, "identification of genetic, familial, and environmental risk factors suspected to participate in the FM syndrome development (may be necessary) to determine the gene frequency of AAT deficiency alleles in FM patients".

Green tea, bioactive polyphenols EGCG, according to the Dr Helieh S in animal model induced by alpha1-Antitrypsin (AAT) (α1-antitrypsin) deficiency exerted a significant anti-inflammatory effect in inhibited the PI3K/Akt signalling pathway with function in activated proinflammatory factors through the innate immune response involved in pathogen killing, antigen processing and immune cell survival.

Moreover, green tea EGCG application also enhanced antioxidant activity not only through its antioxidant profiles but also stimulated the production of the body's natural antioxidants in reduced inflammatory response through nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression, observed by Griess reagent and western blotting.

These results indicated that green tea EGCG may have a profound effect in reduced serum alpha1-Antitrypsin (AAT) deficiency in initiated the onset of fibromyalgia

The above differentiation was supported by the review of Chronic Inflammatory Diseases and Green Tea Polyphenol, by Dr. Helieh S. Oz at the University of Kentucky Medical Center.

According to the authors, green tea polyphenols are potent antioxidants with important roles in regulating vital signaling pathways in activated inflammatory responses by attenuated nuclear factor (NF)-kappaB IKK, NF-κB in facilitated innate- and adaptive immune responses, cell death and inflammation and cytokines like TNFα, inflammatory markers and cyclooxygenase-2 in elevated symptoms of inflammation and pain.


Dr. Helieh S., in summary, said, "green tea polyphenols (GrTPs) are potent antioxidants with important roles in regulating vital signaling pathways" and "these comprise transcription nuclear factor-kappa B mediated I kappas B kinase complex pathways, programmed cell death pathways like caspases and B-cell lymphoma-2 (through regulating the cytochrome c release from the mitochondria) and intervention with the surge of inflammatory markers like cytokines and production of cyclooxygenase-2"".

Taken together, green tea and its bioactive polyphenols may be considered as a functional food in ameliorated serum alpha1-Antitrypsin (AAT) deficiency effect in initiated the onset of fibromyalgia. However, the intake of green tea supplements should be taken with extreme care due to recent medical reports of acute liver toxicity.

For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) alpha1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia by Blanco LE1, de Serres FJ, Fernańdez-Bustillo E, Kassam DA, Arbesú D, Rodríguez C, Torre JC.(PubMed)
(3) Chronic Inflammatory Diseases and Green Tea Polyphenols by Helieh S. Oz(PubMed Central Canada)

Thursday, October 3, 2019

Bromelain, The Natural Prevention and Treatment of Edema

Edema is a condition associated with the abnormal accumulation of fluid in certain tissues within the body.

Depending on the affected area or organs, edema can be peripheral edema or ankle edema, and pulmonary edema if the fluid is accumulated in skin ankle and lung respectively.

Traditional Chinese medicine suggested that fluid accumulation is caused by kidney dysfunction in transport the fluid coming from the pancreas to nourish other body tissues and organs.


In other words, kidney deficiency is a major cause of edema. Similar to the aforementioned condition, conventional medicine also suggested that certain kidney diseases can induce fluid retention in some parts of the body.

Furthermore, heart failure, cirrhosis of the liver, venous insufficiency are also the most common systemic diseases that cause edema, epidemiologically.


Most common risk factors associated with the risk of edema are mostly involved in the lifestyle and general health factors, including staying in one position (sitting, standing or supine) for too long, increased sodium intake and hormonal changes due to menstruation.

Some women during the course of pregnancy also experience symptoms of edema, particularly under the skin of the leg.


Furthermore, the use of medications such as Estrogen-based medication Non-steroidal anti-inflammatory drugs (NSAIDs), certain diabetes medications and medical equipment such as vasodilators has also been found to increase the risk of fluid retention.


Conventionally, the treatment of edema is totally depending on the causes of the disease. Untreated edema has been associated with the complication of skin infections or ulcerating, leading to, decreased blood circulation and increasing the risk of blood clots in the deep veins of the body.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential compound for the treatment of edema, researchers examined the Bromelain-loaded katira gum nanoparticles' effect on an animal model.


According to the tested results, the Nanoparticles of the optimized batch showed a strong anti-inflammatory activity by employing the carrageenan-induced rat paw edema method in vivo.

In other words, the anti-inflammatory activity of potential was attributed to enhanced absorption owing to reduced particle size and the protection of bromelain from acid proteases.

Moreover, according to the search of the computerized bibliographic databases Medline, EMBASE, Scopus, and CINAHL was performed on March 23, 2015, researchers found 7 studies used oral bromelain for the treatment of edema.


5/7 randomized controlled trials reported improvement postprocedure with oral bromelain compared to those of arnica,

Taken altogether, oral bromelain may be used for the treatment of edema, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature by Ho D1, Jagdeo J, Waldorf HA. (PubMed)
(2) Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles by Bernela M1, Ahuja M2, Thakur R. (PubMed)

Green Tea, The Beverage Which Blocks The Onset of Ulcerative Colitis, Researchers Find

Green tea may have a therapeutic and positive effect on prevention and treatment of Ulcerative Colitis, some scientists suggested.

Ulcerative Colitis is a digestive condition characterized by inflammatory bowel disease (IBD) that induces chronic inflammation and ulcers (sores) in the digestive tract.

According to statistics, approximately, between 250,000 and 500,000 people are infected by ulcerative colitis in the United States. The risk of ulcerative colitis onset is between 2 to 7 per 100,000 persons.

Most common symptoms are abdominal pain and diarrhea. However, some patients may also experience symptoms of fatigue or tiredness, loss of appetite, dehydration feeling the urge to empty the bowels constantly,.... and weight loss.

If you have some of the symptoms above, please check with your doctor to rule out the possibility of ulcerative colitis.

Researchers do not know the exact cause of Ulcerative Colitis.

Neither they know why ulcerative colitis induces chronic inflammation and ulcers (sores) in the digestive tract.

However, they do know that certain risk factors are associated to the development of the disease, including genetic mutation of a certain gene, environmental toxins, overreaction of the immune system,.... and long-term high levels of linoleic acid intake.

Green tea, a precious drink processes numbers of health benefits known to almost everyone in Asia and the Western world.

As yin in nature, long-term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Mild to moderate ulcerative colitis (UC) patients, 15 received 400 mg or 800 mg of total Polyphenon E daily, administered in split doses or and 4 in placebo in a double-blinded, placebo-controlled pilot study, researchers at the end of the experiential indicated that oral administration of the extracts exerts a potential effect of reduced levels of inflammation through the improvement of the reading of the mean UC disease activity index score compared to the entry score.

After 56 days of therapy, the Polyphenon E treatment group exhibited strong improvement of over-response rate of 66.7% (10 of 15) and a remission rate of 53.3% (8/15) compared to 0% (0/4) in both response rate and remission rate in the placebo group.

Dr. Dryden GW, the lead author, after taking into account of other co-founder said, "Administration of Polyphenon E resulted in a therapeutic benefit for(ulcerative colitis (UC)) patients who were refractory to 5-aminosalicylic and/or azathioprine".

Polyphenon E is high-quality tea catechin extracted from natural tea leaves.

Further analysis of green tea bioactive polyphenols, epigallocatechin gallate (EGCG) on dextran sulfate sodium- (DSS-) induced ulcerative colitis in rats and to explore the roles of TLR4/MyD88/NF-κB signaling pathway, indicated that application of the extract significantly improves the intestinal mucosal injury in rats through inhibited production of inflammatory factors which were overexpression during the acute phase of injuring and damage to induced further damage to the tissue.

Moreover, green tea bioactive polyphenols, epigallocatechin gallate (EGCG) also reduced chronic inflammation and maintained the balance of the ratio of Th1/Th2 T-helper (Th) lymphocytes that prevent alterations in cellular immunity in patients with ulcerative colitis.

Imbalance of Th1/Th2 was found to associate with the occurrence and development of ulcerative colitis.

Additionally, injection of green tea EGCG also reduced the levels of TLR4 signaling in activated the intracellular signaling pathway NF-κB and inflammatory cytokine production to imitate inflammation.

Amazingly, researchers also found that injection of TLR4 antagonism not only shows a significantly reduced the protective effect of EGCG on intestinal mucosal injury colitis but also increased the expressions of inflammatory factors in the production of pro-inflammatory cytokines.

Moreover, in the examine the antioxidant activity of green tea catechins in model of colitis induced by 2.4.6 trinitrobenzene sulfonic acid (TNBS) using 35 young adult Sprague-Dawley rats which are divided into four groups: normal control (n=5), catechins (n=9), TNBS (n=9) and 2.4.6 trinitrobenzene sulfonic acid (TNBS) plus catechins (n=12), at the end of the experiment researchers at the Joint study, American University of Beirut, found that groups with TNBS and catechin express strong anti-inflammatory and anti-oxidant effects of amelioration of symptoms and expression of ulcerative colitis through stabilizing the mast cells production, induced by injection of TNBS in compared to TNBS treated group.

Dr. the lead authors in the joint study suggested that the study depicted a significant amelioration in the TNBS- and EGCG-treated rats compared to the non-treated animals in similar to histological data, as the mechanism of action occurred basically through the NF-kB pathway and possibly through crosstalk with other pathways.

Taken together, green tea and its bioactive polyphenols may be considered as functional foods for the prevention and treatment of ulcerative colitis through the expression of antioxidant and anti-inflammatory activity.

Intake of green tea extract should be taken with extreme care as acute toxicity has been reported in some cases.

https://kylejnorton.blogspot.com/2018/09/green-tea-beverage-which-blocks-onset.html



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca



Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299



Sources
(1) A pilot study to evaluate the safety and efficacy of an oral dose of (-)-epigallocatechin-3-gallate-rich polyphenon E in patients with mild to moderate ulcerative colitis by Dryden GW1, Lam A, Beatty K, Qazzaz HH, McClain CJ. (PubMed)
(2) Tea catechins induce crosstalk between signaling pathways and stabilize mast cells in ulcerative colitis by Gerges Geagea A1,2, Rizzo M2, Eid A1, Hajj Hussein I3, Zgheib Z1, Zeenny MN1, Jurjus R4, Uzzo ML5, Spatola GF5, Bonaventura G5, Leone A5, Massaad-Massade L6,7,8, Jurjus A1.(PubMed)
(3) EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF-κB Signaling Pathway in Rats by TNBS,1 Liu Xuelei,2 Dong Wanwei,3 Liang Linlang,1 and Chen Keyan3(Hindawi)

Wednesday, October 2, 2019

Green Tea and its Bioactive Polyphenol EGCG in Reduced Risk, Progression and Treatment of Psoriasis and Initiation of Psoriatic Arthritis

Green tea may have a therapeutic and positive effect in reduced risk, progression and treatment of psoriasis, some scientists suggested.

Psoriasis is an immuno-inflammatory disease characterized by speeding up the life cycle of skin cells to induce skin cells to build up rapidly on the surface.

Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.


In the investigation of green tea EGCG effect on BALB/c mice induced psoriasis by topically treated with imiquimod (IMQ) for 6 consecutive days, as a psoriasis mouse model, researchers found that application of green tea bioactive compound demonstrated a significant effect in improved psoriasiform dermatitis and the skin pathological structure by inhibited the proliferating cell nuclear antigen (PCNA) which has been found in elevated levels in patient with psoriasis.

The levels of proliferating cell nuclear antigen (PCNA) considered as a biomarker and an abnormally proliferating cell pool in patients with skin cancer was also inhibited by EGCG injection


Administration of EGCG promoted caspase-14 expression which has been altered in patients with psoriasis to orchestrate epidermal differentiation in decreased in inflammatory lesions in atopic dermatitis through its function as a novel regulator of skin cell differentiation and skin barrier formation to protect the skin cell against inflammation.


Treatment of EGCG also attenuated skin inflammation through reduced levels of inflammatory factors such as interleukin (IL)-17A, a pro-inflammatory cytokine, produced by a group of T helper cells and IL-17F a pro-inflammatory cytokine and immune mediator in trigger the innate immune activity in the acute phase of infection.


Furthermore, injection of green EGCG also inhibited the T helper (Th) cell subsets IL-22 in secreted cytokines in stimulated immune the defense against certain microbes and the development and maintenance of chronic inflammatory diseases and IL-23 in enhanced the expansion of T helper type 17 (Th17) cells which has been found to associate to prevalence of many of the inflammatory autoimmune responses, including psoriasis.

Significantly, green tea also reduced infiltrations of T cells in facilitating inflammatory skin lesions caused by the injection of imiquimod (IMQ).


Moreover, EGCG also ameliorated the production of malondialdehyde (MDA), an end product of lipid peroxidation in plasma observed by the protocol with colorimetric Diagnostic Reagent Kit an indication of overproduction of reactive oxygen species (ROS) in precipitated free radical chain reaction to induced oxidative stress caused by psoriasis through expression of its antioxidants and induced production of natural antioxidants in the body.


Importantly, the application of green tea compound increased percentages of CD4+ T cells in immunocytes in the activated a series of local immunologically mediated stimulatory events that produce further T cell activation and appearance against triggers conversion of symptomless (PN) skin into psoriatic plaques (PP skin).

Dr. Shuangshuang Zhang, the lead author after taking into account other confounder said, " (
EGCG attenuates the IMQ-induced histological changes of skin) of marked hyperkeratosis, parakeratosis, modest acanthosis, elongated rete ridges, and modest dermal inflammation...., increased parakeratosis, acanthosis and inflammatory cell infiltration (caused by IMQ)".

EGCG exerted anti-inflammatory, immune regulatory and antioxidant effects in ameliorated expression of psoriasis may also have strong implications in prevented psoriasis in the induction of chronic inflammation of the joint in catalyzed psoriatic arthritis.


Taken together, green tea and its bioactive polyphenol EGCG may be considered as a functional food for reduced risk, progression and used with conventional medicine for the treatment of psoriasis. However, the intake of green tea supplements should be taken with exceptional care as acute liver toxicity was reported in several medical literatures.



For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice by Shuangshuang Zhang,#1 Xiangdong Liu,#2 Lihong Mei,1 Hongfeng Wang,1 and Fang Fang(PMC)

Collard Greens Inhibits the Fat Accumulation in Obese Patients

Obesity is a chronic condition characterized by excess body fat that has accumulated over time. People with a BMI of over 30 is considered obese.

Similarly, overweight is a condition of excess body weight relative to height. People with a BMI ranged from 25 to 29.9 is considered overweight.

According to the statistics, 68% of the American population is either overweight or obese. Obesity has been found to induce adverse effects nearly every system of the human body, leading to an increased risk of numerous diseases, including diabetes and cardiovascular disease.

Furthermore, the rate of obesity in the US and Canada continues to climb at an alarming rate, leading to significant burdens to the country's economy and health care system.

Epidemiologically, most common symptoms of obesity are breathlessness, increased sweating, inability to cope with physical activity, feeling very tired every day, back and joint pains, low confidence, and self-esteem and feeling isolation

According to the CDC, the most common complications associated with obesity are coronary heart disease, stroke, type 2 diabetes, cancer of breast, colon, endometrial, gallbladder, kidney, and liver and sleep apnea.

Currently, there is no effective treatment of the disease. However, some researchers suggested that combat the powerful environmental factors that influence eating and physical activity may be the best approach to reduce the risk of obesity.

Bariatric surgery is used as an option for management that causes a reduction in the amount of food you are or a reduction in the absorption of calories from the food you eat, or both.


The surgery has been proposed to patients with extreme obesity (BMI of 40 or higher) due to weight-induced a serious weight-related health problem, such as diabetes or high blood pressure.

Furthermore, this type of surgery has posed a serious risk of many patients if the commitment of making lifelong changes in the eating and exercise habits cannot be followed through.

Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

With an aim to find a natural food for the prevention and treatment of obesity, researchers examined the effect of sulforaphane found abundantly in collard greens.


In a high-fat diet (HFD)-induced obesity in C57BL/6N mice which were fed a normal diet (ND), HFD or HFD plus 0.1% sulforaphane (SFN) for 6 weeks, researchers found that SFN administration not only attenuated HFD-induced visceral adiposity that stored around a number of important internal organs such as the liver, pancreas and intestines, adipocyte hypertrophy associated with an enlargement of adipose tissue but also ameliorated fat accumulation in the liver.

Furthermore, SFN decreased the elevated levels of serum total cholesterol and leptin, and liver triglyceride in HFD-SFN-fed mice compared to HFD-fed mice.


SFN also inhibited the expression of a gene associated with the promotion of inflammation in the adipose tissue of HFD-SFN mice and increased the adiponectin function in regulating glucose levels and fatty acid breakdown.

Moreover, reductase expression associated with the production of cholesterol was decreased and an antibody associated with fatty acid utilization was increased in lycopene treat group compared with HFD-fed mice.

Taken altogether, collard green processed abundantly SFN may be considered supplements for the prevention and treatment of obesity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Potential effects of sulforaphane to fight obesity by Martins T1, Colaço B1,2, Venâncio C1,2, Pires MJ1,3, Oliveira PA1,3, Rosa E1, Antunes LM. (PubMed)
(2) Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice by Kyeong-Mi Choi, Youn-Sun Lee, Wonkyun Kima, Seung Jung Kimb, Kyong-Oh Shina, Ji-YeonYuc, Mi Kyeong Lee, Yong-Moon Lee, Jin Tae Honga, Yeo-PyoYuna, Hwan-SooYooa. (Science Direct)

Tuesday, October 1, 2019

Phytochemical Betanin, the Best Free Radical Scavenger


Antioxidants are stable atoms which inhibit oxidation caused by free radical.

Free radical scavengers are types of antioxidants that inhibit free radicals before they can orchestrate a chain reaction that can not be stopped until all electrons in the outermost ring are paired or inhibited by antioxidants.

Oxidative stress is associated with chronic disease due to the imbalanced ratio of free radicals and antioxidants produced by the host includes heart disease, stroke, and diabetes.

Antioxidants besides produced by the body, they can also come into the body dietary sources.

In a healthy individual, an antioxidant produced by the body is good enough to counter the expression of free radicals induced by cell metabolism and free radicals induced by the environment such as the air we breathe and the food we eat.

However, people with a weakened immune system, intake of antioxidants from outside sources such as fruits and vegetables can be helpful.

Believe it or not. moderate free radicals in the body are necessary for body functioning, including the promotion of heart function in blood circulation.

Most common types of free radical scavengers include
* Catalases, the very important enzyme is produced by the host that protects the cell from oxidative damage by free radicals.

*Glutathione peroxidase, is a cytosolic enzyme produced by the host that dissolves hydrogen peroxide to water and oxygen and peroxide radicals to alcohols and oxygen.

*Superoxide dismutase (SOD), is also produced by the host that dissolves superoxide radical into either ordinary molecular oxygen or hydrogen peroxide.

*Vitamin E, Vitamin C, and vitamin D.

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

In the urgency to find a natural compound for the treatment of diseases associated with overexpression of free radicals, researchers examined the betanin free radical scavenging activity.

According to the Trolox equivalent antioxidant capacity (TEAC) assay, at a pH > 4, betanin is about 1.5-2.0-fold more active to scavenge free radical compared to those of anthocyanins.

More precisely, the exceptionally high antioxidant activity of betanin was associated with an increase of its H-donation and electron-donation ability, totally depending on the expression of cationic state to mono-, di- and tri-deprotonated states present at basic solutions.


In other words, the efficacy of betanin high free radical scavenging activity was dependent on the levels of pH.

Taken altogether, betanin may be considered supplements for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of larger sample size and multicenter human study.

Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betanin, the main pigment of red beet: molecular origin of its exceptionally high free radical-scavenging activity by Gliszczyńska-Swigło A1, Szymusiak H, Malinowska P. (PubMed)
(2) Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes by Tesoriere L1, Allegra M, Gentile C, Livrea MA. (PubMed)

Healthy Food Navy Bean, a Natural Treatment of High Blood Cholesterol

Cholesterol is a way substance produced by the liver or from food sources plays an important role to build strong cell membranes and produce steroid hormone and vitamin D and aiding the digestive tract in absorbing the nutrients for our body need.

Hyperlipidemia is also one of condition found in the cluster of metabolic syndrome.

In a healthy individual, excess cholesterol is returned to the liver after performing the aforementioned function by high-density lipoprotein or "good cholesterol".

However, a prolonged period of overexpression of abnormal blood cholesterol due to excessive consumption of fat or reduced levels of "good cholesterol" in the bloodstream can cause plaque building up on the arterial wall, leading to heart diseases and stroke.

Depending on the choice of diet, your risk of high blood cholesterol can be increased or decreased.


The healthy ratio of blood cholesterol is 4 (low-density lipoprotein) to 1 (high-density lipoprotein).

If your ratio is lower than 4, you are considered to have a healthy blood cholesterol ratio.

Hyperlipidemia is preventable. If you have high blood cholesterol, reducing bad fat intake accompanied by an increased intake of "good cholesterol" with moderate exercise can be helpful.

More precisely, by changing to a healthy diet and lifestyle with moderate exercise, you are at the lower risk of high blood cholesterol sometimes in the future (weeks or months, depending on the levels of blood cholesterol today).

People who follow the Western diet with a high in saturated and trans fat, red meat, processed food and low in fruits and vegetables and whole grains may have a substantially increased risk of abnormally high blood cholesterol.

According to the article "Western Diet and Heart Risk", the author wrote, "Western diets cause a third of heart attack deaths worldwide,” the Daily Mail reports. Western-style diets high in meat, fat, dairy and salt put people at higher risk of a heart attack. According to the newspaper, a study has found that poor diet is responsible for 30% of the risk of heart disease".

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.

On finding a dietary source for the treatment of high blood cholesterol, researchers examined whether cooked navy bean powder (NBP) and/or heat-stabilized rice bran (RB) supplementation is tolerable, improves dietary fiber intake in children, and modulates lipid profiles.

The study included children aged 8 to 13 years at risk for CVD due to abnormal lipids. In other words, all participants were diagnosed with elevated cholesterol levels including total cholesterol ≥180 mg/dL and high-density lipoprotein (HDL) <60 mg/dL; low-density lipoprotein (LDL) ≥100 mg/dL and HDL <60 mg/dL; or non-HDL >100 mg/dL and HDL <60 mg/dL.

Participants received muffins or a smoothie daily that included 0 g NBP or RB (control), 17.5 g NBP, 15 g RB, or a combination 9 g NBP + 8 g RB. Fasting blood was collected at baseline and week 4.


Only 38 children completed the trial, including n = 9 control, n = 10 NBP, n = 9 RB, and n = 10 NBP + RB groups.

Additionally, participants in the intervention groups significantly increased intake of NBP and RB at week 4 (p≤.01), particularly increased fibers in NBP and NBP + RB groups from baseline to week 4.

Based on the tested assays, HDL-cholesterol was higher in NBP-group participants compared to control at week 4.

Although other lipid parameters also showed signs of decreasing, they are insignificantly due to the
shorter duration in the experiment (4 weeks).

In other words, higher daily intakes are needed for a longer duration to induce favorable changes across multiple serum lipid parameters.

Taken altogether, the navy bean may be considered a remedy for the prevention and treatment of high blood cholesterol, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Pilot Randomized Controlled Clinical Trial to Assess Tolerance and Efficacy of Navy Bean and Rice Bran Supplementation for Lowering Cholesterol in Children by Borresen EC1, Jenkins-Puccetti N2, Schmitz K1, Brown DG1, Pollack A2, Fairbanks A1, Wdowik M1, Rao S1, Nelson TL1, Luckasen G3, Ryan EP. (PubMed)
(2) Western diet and heart risk, Tuesday, October 21, 2008, by NHS