Green Tea and its Bioactive Polyphenol EGCG in Reduced Risk, Progression and Treatment of Psoriasis and Initiation of Psoriatic Arthritis

Green tea may have a therapeutic and positive effect in reduced risk, progression and treatment of psoriasis, some scientists suggested.

Psoriasis is an immuno-inflammatory disease characterized by speeding up the life cycle of skin cells to induce skin cells to build up rapidly on the surface.

Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.


In the investigation of green tea EGCG effect on BALB/c mice induced psoriasis by topically treated with imiquimod (IMQ) for 6 consecutive days, as a psoriasis mouse model, researchers found that application of green tea bioactive compound demonstrated a significant effect in improved psoriasiform dermatitis and the skin pathological structure by inhibited the proliferating cell nuclear antigen (PCNA) which has been found in elevated levels in patient with psoriasis.

The levels of proliferating cell nuclear antigen (PCNA) considered as a biomarker and an abnormally proliferating cell pool in patients with skin cancer was also inhibited by EGCG injection


Administration of EGCG promoted caspase-14 expression which has been altered in patients with psoriasis to orchestrate epidermal differentiation in decreased in inflammatory lesions in atopic dermatitis through its function as a novel regulator of skin cell differentiation and skin barrier formation to protect the skin cell against inflammation.


Treatment of EGCG also attenuated skin inflammation through reduced levels of inflammatory factors such as interleukin (IL)-17A, a pro-inflammatory cytokine, produced by a group of T helper cells and IL-17F a pro-inflammatory cytokine and immune mediator in trigger the innate immune activity in the acute phase of infection.


Furthermore, injection of green EGCG also inhibited the T helper (Th) cell subsets IL-22 in secreted cytokines in stimulated immune the defense against certain microbes and the development and maintenance of chronic inflammatory diseases and IL-23 in enhanced the expansion of T helper type 17 (Th17) cells which has been found to associate to prevalence of many of the inflammatory autoimmune responses, including psoriasis.

Significantly, green tea also reduced infiltrations of T cells in facilitating inflammatory skin lesions caused by the injection of imiquimod (IMQ).


Moreover, EGCG also ameliorated the production of malondialdehyde (MDA), an end product of lipid peroxidation in plasma observed by the protocol with colorimetric Diagnostic Reagent Kit an indication of overproduction of reactive oxygen species (ROS) in precipitated free radical chain reaction to induced oxidative stress caused by psoriasis through expression of its antioxidants and induced production of natural antioxidants in the body.


Importantly, the application of green tea compound increased percentages of CD4+ T cells in immunocytes in the activated a series of local immunologically mediated stimulatory events that produce further T cell activation and appearance against triggers conversion of symptomless (PN) skin into psoriatic plaques (PP skin).

Dr. Shuangshuang Zhang, the lead author after taking into account other confounder said, " (
EGCG attenuates the IMQ-induced histological changes of skin) of marked hyperkeratosis, parakeratosis, modest acanthosis, elongated rete ridges, and modest dermal inflammation...., increased parakeratosis, acanthosis and inflammatory cell infiltration (caused by IMQ)".

EGCG exerted anti-inflammatory, immune regulatory and antioxidant effects in ameliorated expression of psoriasis may also have strong implications in prevented psoriasis in the induction of chronic inflammation of the joint in catalyzed psoriatic arthritis.


Taken together, green tea and its bioactive polyphenol EGCG may be considered as a functional food for reduced risk, progression and used with conventional medicine for the treatment of psoriasis. However, the intake of green tea supplements should be taken with exceptional care as acute liver toxicity was reported in several medical literatures.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice by Shuangshuang Zhang,#1 Xiangdong Liu,#2 Lihong Mei,1 Hongfeng Wang,1 and Fang Fang(PMC)