Green tea may have a therapeutic and positive effect on improved glucose metabolism, some scientists suggested.
Glucose metabolism is an action of the body to convert glucose intake to energy to nourish the body tissues and organs through oxidized to carbon dioxide and water.
Long term abnormal glucose metabolism is considered as a leading cause of diabetes and diabetic complications.
Green tea extract, in the evaluation of the on carbohydrate metabolic key enzymes in control and streptozotocin high fat diet-induced diabetic rats in 30 days, demonstrated significant activity in ameliorated the overexpression of plasma glucose, glycosylated hemoglobin (HbA1c) and increase in the levels of insulin and hemoglobin.
Further analysis also found that the application exerted a profound effect in restore, in some extends, the function of altered activities of the key enzymes of carbohydrate metabolism, such as hexokinase, pyruvate kinase, lactate dehydrogenase in both diabetic and control groups.
In the diabetic rat's group, green tea extract strongly averted the abnormal expression of glycogen phosphorylase in the liver to near-normal levels.
Additionally, the diabetic group after administration of green tea extract exhibited antihyperglycemic potential, observed through improved muscle and hepatic glycogen content.
The information findings showed green tea extract have a directed implication in attenuated abnormal glucose metabolism in compared to the effectiveness of conventional medicine metformin, a standard oral hypoglycemic drug.
Moreover, in the study to confirm the epidemiological study suggestion of improvement in glucose metabolism in diabetic mice and healthy humans upon green tea consumption, researchers found that
injection green tea in diabetic mice and streptozotocin-induced diabetic mice after 2-6 h expresses lower levels of glucose with no alternation of serum insulin level, at a dose of 300 mg/kg in compared to normal control mice.
In protein differentiation, green tea extract administration decreased the serum protein level which has been associated with glucose production, minimized the increase of blood glucose levels through stimulating additional small amounts of insulin in diabetes. These results addressed another indication of green tea function in exerted direct influence in the modulation of glucose metabolism in the tested subject.
Interestingly, in the investigation of green tea effect in glucose uptake inhibitory activity in Caco-2 cells, researchers indicated that green tea at a temperature of 60 degrees in Celsius significantly improved the capacity of antioxidants in inhibition of glucose uptake through regulation of cellular glucose metabolism.
Incredibly, temperature over 60 degrees Celsius, green tea application did not increase or showed an upward trend in the inhibitory potential, the Huazhong Agricultural University suggested.
Taken together, green tea with abundant bioactive phytochemicals may be considered as a functional food in improved glucose metabolism in reduced risk of diabetes onset. People in high-risk diabetes such as prediabetics may want to add 1 or 2 cups of green tea into their diet for preventive measures.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats by Sundaram R1, Naresh R, Shanthi P, Sachdanandam P.(PubMed)
(2) Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans by Tsuneki H1, Ishizuka M, Terasawa M, Wu JB, Sasaoka T, Kimura I.(PubMed)
(3) Effect of steeping temperature on antioxidant and inhibitory activities of green tea extracts against α-amylase, α-glucosidase and intestinal glucose uptake by Liu S1, Ai Z2, Qu F3, Chen Y4, Ni D5.(PubMed)
Saturday, October 5, 2019
Friday, October 4, 2019
Collard Green Protects the Nerves Against the Risk of Peripheral Neuropathy in Diabetes
Diabetic neuropathy is a complication of patients with diabetes associated with nerve damage, inducing pain and numbness in the legs and feet to conditions associated with the digestive system.
Most cases of diabetic neuropathy in diabetics are involved in a history of hyperglycemia caused by long-term high levels of glucose in the bloodstream, urinary tract, blood vessels, and heart due to poor lifestyle.
Peripheral neuropathy is the main type of diabetic neuropathy, affecting the nerves that control the feet and legs first, followed by the hands and arms. Other main types of diabetic neuropathy are
* The autonomic neuropathy that affects the nerves that control the heart, bladder, stomach, intestines, sex organs and eyes.
* Radiculoplexus neuropathy found mostly in older patients affects nerves that control the thighs, hips, buttocks or legs.
* Mononeuropathy, or focal neuropathy also found commonly in older patients affects the nerves that control the face, middle of the body (torso) or leg.
The most common signs and symptoms of peripheral neuropathy are a gradual onset of numbness, prickling or tingling in the feet or hands, over time which can spread upward into your legs and arms.
Some patients with peripheral neuropathy may also experience sharp, jabbing, throbbing or burning pain and skin that extreme sensitivity to touch.
The causes of peripheral neuropathy that damage nerves and blood vessels in the affected area has been found to induce by overtime, uncontrolled high blood sugar.
In other words, peripheral neuropathy is preventable by keeping the blood glucose in the healthy range.
Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.
With an aim to find a potential compound for the prevention of diabetes complications-induced loss of limbs' sensation that results in lower limb amputation in patients with diabetes, researchers examined the effects of sulforaphane on peripheral neuropathy in an animal model.
The experiment included diabetes rats induced through single intraperitoneal injections of nicotinamide (50 mg/kg) and streptozotocin (52.5 mg/kg) randomly divided into five groups
* Two groups were treated with saline or sulforaphane
* Three diabetic groups were either untreated or given sulforaphane (1 mg/kg, p.o.) or pregabalin (10 mg/kg, i.p.).
According to the results of tested analysis after 2 weeks, groups treated with sulforaphane restored animals' body weight, reduced levels of blood glucose in the nicotinamide (50 mg/kg) and streptozotocin (52.5 mg/kg) treated group
Furthermore, glycated hemoglobin and increased insulin levels were also normalized by the administration of sulforaphane, compared to the untreated diabetes groups,
Histopathological changes induced by the nicotinamide (50 mg/kg) and streptozotocin were also reversed in the sulforaphane-treated group observed by the normalizing motor coordination and the latency withdrawal time and increasing the latency withdrawal time.
Furthermore, sulforaphane also decreased markers (malondialdehyde) of oxidative stress of sciatic nerve and inhibited the overexpression of free radicals in the initiation of the production of proinflammatory cytokines and cellular damage compared to untreated groups.
Moreover, levels of antioxidant enzymes in the sciatic nerves produced the treatment groups also significant increase by the injection of sulforaphane.
The results strongly suggested that sulforaphane processed a neuroprotective effect against peripheral neuropathy in diabetic rats possibly through modulating oxidative stress, inflammation, and extracellular matrix associated with cellular differentiation remodeling,
Collectively, researchers wrote in the final report, " In NA-STZ model of diabetes mellitus, sulforaphane, restored animals' body weight, reduced blood glucose, glycated hemoglobin, and increased insulin levels. In parallel, it normalized motor coordination and the latency withdrawal time of the tail-flick test increased the latency withdrawal time of cold allodynia test and ameliorated histopathological changes".
Taken altogether, collard green processed abundantly bioactive compound sulforaphane may be considered supplements for the prevention and treatment of peripheral neuropathy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Extracellular Matrix Remodeling and Modulation of Inflammation and Oxidative Stress by Sulforaphane in Experimental Diabetic Peripheral Neuropathy by Moustafa PE1, Abdelkader NF2, El Awdan SA3, El-Shabrawy OA3, Zaki HF. (PubMed)
Most cases of diabetic neuropathy in diabetics are involved in a history of hyperglycemia caused by long-term high levels of glucose in the bloodstream, urinary tract, blood vessels, and heart due to poor lifestyle.
Peripheral neuropathy is the main type of diabetic neuropathy, affecting the nerves that control the feet and legs first, followed by the hands and arms. Other main types of diabetic neuropathy are
* The autonomic neuropathy that affects the nerves that control the heart, bladder, stomach, intestines, sex organs and eyes.
* Radiculoplexus neuropathy found mostly in older patients affects nerves that control the thighs, hips, buttocks or legs.
* Mononeuropathy, or focal neuropathy also found commonly in older patients affects the nerves that control the face, middle of the body (torso) or leg.
The most common signs and symptoms of peripheral neuropathy are a gradual onset of numbness, prickling or tingling in the feet or hands, over time which can spread upward into your legs and arms.
Some patients with peripheral neuropathy may also experience sharp, jabbing, throbbing or burning pain and skin that extreme sensitivity to touch.
The causes of peripheral neuropathy that damage nerves and blood vessels in the affected area has been found to induce by overtime, uncontrolled high blood sugar.
In other words, peripheral neuropathy is preventable by keeping the blood glucose in the healthy range.
Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.
With an aim to find a potential compound for the prevention of diabetes complications-induced loss of limbs' sensation that results in lower limb amputation in patients with diabetes, researchers examined the effects of sulforaphane on peripheral neuropathy in an animal model.
The experiment included diabetes rats induced through single intraperitoneal injections of nicotinamide (50 mg/kg) and streptozotocin (52.5 mg/kg) randomly divided into five groups
* Two groups were treated with saline or sulforaphane
* Three diabetic groups were either untreated or given sulforaphane (1 mg/kg, p.o.) or pregabalin (10 mg/kg, i.p.).
According to the results of tested analysis after 2 weeks, groups treated with sulforaphane restored animals' body weight, reduced levels of blood glucose in the nicotinamide (50 mg/kg) and streptozotocin (52.5 mg/kg) treated group
Furthermore, glycated hemoglobin and increased insulin levels were also normalized by the administration of sulforaphane, compared to the untreated diabetes groups,
Histopathological changes induced by the nicotinamide (50 mg/kg) and streptozotocin were also reversed in the sulforaphane-treated group observed by the normalizing motor coordination and the latency withdrawal time and increasing the latency withdrawal time.
Furthermore, sulforaphane also decreased markers (malondialdehyde) of oxidative stress of sciatic nerve and inhibited the overexpression of free radicals in the initiation of the production of proinflammatory cytokines and cellular damage compared to untreated groups.
Moreover, levels of antioxidant enzymes in the sciatic nerves produced the treatment groups also significant increase by the injection of sulforaphane.
The results strongly suggested that sulforaphane processed a neuroprotective effect against peripheral neuropathy in diabetic rats possibly through modulating oxidative stress, inflammation, and extracellular matrix associated with cellular differentiation remodeling,
Collectively, researchers wrote in the final report, " In NA-STZ model of diabetes mellitus, sulforaphane, restored animals' body weight, reduced blood glucose, glycated hemoglobin, and increased insulin levels. In parallel, it normalized motor coordination and the latency withdrawal time of the tail-flick test increased the latency withdrawal time of cold allodynia test and ameliorated histopathological changes".
Taken altogether, collard green processed abundantly bioactive compound sulforaphane may be considered supplements for the prevention and treatment of peripheral neuropathy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Extracellular Matrix Remodeling and Modulation of Inflammation and Oxidative Stress by Sulforaphane in Experimental Diabetic Peripheral Neuropathy by Moustafa PE1, Abdelkader NF2, El Awdan SA3, El-Shabrawy OA3, Zaki HF. (PubMed)
Green Tea and Its Bioactive Polyphenols in Reduced Alpha1-Antitrypsin (AAT) Deficiency in Induction of Fibromyalgia
Green tea may have a therapeutic and positive effect on the reduced onset. progression and treatment of Alpha1-Antitrypsin (AAT) deficiency in induced fibromyalgia, some scientists suggested.
Green tea is a precious drink that processed a number of health benefits and known to almost everyone in Asia and the Western world.
Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people in the US alone.
Serum of alpha1-Antitrypsin (AAT) impregnated in most body tissues circulates in our body in high concentrations with function as a broad anti-inflammatory spectrum in inhibition of enzymes of inflammatory cells, especially neutrophil elastase.
In the study of the effect of serum of alpha1-Antitrypsin (AAT) and risk of fibromyalgia (FM), researchers at the Hospital Valle del Nalón found that deficiency of AAT has been found in numbers of patients with fibromyalgia (FM) with severe hereditary.
Functional magnetic resonance imaging of these patients revealed significant greater activity in pain-sensitive areas of the brain in response to cutaneous stimuli, which may be another evidence for a physiological explanation for FM pain.
Furthermore, patients with FM also were found to consist of abnormal profiles of inflammation markers in biopsies analysis.
The results suggested that these patients may have an imbalance level of pro-inflammatory and anti-inflammatory substances, in the soft body tissues caused by alpha1-Antitrypsin (AAT) deficiency.
Due to surprising findings, Dr. Blanco LE, the lead author, after taking into account of other confounders, said, "identification of genetic, familial, and environmental risk factors suspected to participate in the FM syndrome development (may be necessary) to determine the gene frequency of AAT deficiency alleles in FM patients".
Green tea, bioactive polyphenols EGCG, according to the Dr Helieh S in animal model induced by alpha1-Antitrypsin (AAT) (α1-antitrypsin) deficiency exerted a significant anti-inflammatory effect in inhibited the PI3K/Akt signalling pathway with function in activated proinflammatory factors through the innate immune response involved in pathogen killing, antigen processing and immune cell survival.
Moreover, green tea EGCG application also enhanced antioxidant activity not only through its antioxidant profiles but also stimulated the production of the body's natural antioxidants in reduced inflammatory response through nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression, observed by Griess reagent and western blotting.
These results indicated that green tea EGCG may have a profound effect in reduced serum alpha1-Antitrypsin (AAT) deficiency in initiated the onset of fibromyalgia
The above differentiation was supported by the review of Chronic Inflammatory Diseases and Green Tea Polyphenol, by Dr. Helieh S. Oz at the University of Kentucky Medical Center.
According to the authors, green tea polyphenols are potent antioxidants with important roles in regulating vital signaling pathways in activated inflammatory responses by attenuated nuclear factor (NF)-kappaB IKK, NF-κB in facilitated innate- and adaptive immune responses, cell death and inflammation and cytokines like TNFα, inflammatory markers and cyclooxygenase-2 in elevated symptoms of inflammation and pain.
Dr. Helieh S., in summary, said, "green tea polyphenols (GrTPs) are potent antioxidants with important roles in regulating vital signaling pathways" and "these comprise transcription nuclear factor-kappa B mediated I kappas B kinase complex pathways, programmed cell death pathways like caspases and B-cell lymphoma-2 (through regulating the cytochrome c release from the mitochondria) and intervention with the surge of inflammatory markers like cytokines and production of cyclooxygenase-2"".
Taken together, green tea and its bioactive polyphenols may be considered as a functional food in ameliorated serum alpha1-Antitrypsin (AAT) deficiency effect in initiated the onset of fibromyalgia. However, the intake of green tea supplements should be taken with extreme care due to recent medical reports of acute liver toxicity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) alpha1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia by Blanco LE1, de Serres FJ, Fernańdez-Bustillo E, Kassam DA, Arbesú D, Rodríguez C, Torre JC.(PubMed)
(3) Chronic Inflammatory Diseases and Green Tea Polyphenols by Helieh S. Oz(PubMed Central Canada)
Green tea is a precious drink that processed a number of health benefits and known to almost everyone in Asia and the Western world.
Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people in the US alone.
Serum of alpha1-Antitrypsin (AAT) impregnated in most body tissues circulates in our body in high concentrations with function as a broad anti-inflammatory spectrum in inhibition of enzymes of inflammatory cells, especially neutrophil elastase.
In the study of the effect of serum of alpha1-Antitrypsin (AAT) and risk of fibromyalgia (FM), researchers at the Hospital Valle del Nalón found that deficiency of AAT has been found in numbers of patients with fibromyalgia (FM) with severe hereditary.
Functional magnetic resonance imaging of these patients revealed significant greater activity in pain-sensitive areas of the brain in response to cutaneous stimuli, which may be another evidence for a physiological explanation for FM pain.
Furthermore, patients with FM also were found to consist of abnormal profiles of inflammation markers in biopsies analysis.
The results suggested that these patients may have an imbalance level of pro-inflammatory and anti-inflammatory substances, in the soft body tissues caused by alpha1-Antitrypsin (AAT) deficiency.
Due to surprising findings, Dr. Blanco LE, the lead author, after taking into account of other confounders, said, "identification of genetic, familial, and environmental risk factors suspected to participate in the FM syndrome development (may be necessary) to determine the gene frequency of AAT deficiency alleles in FM patients".
Green tea, bioactive polyphenols EGCG, according to the Dr Helieh S in animal model induced by alpha1-Antitrypsin (AAT) (α1-antitrypsin) deficiency exerted a significant anti-inflammatory effect in inhibited the PI3K/Akt signalling pathway with function in activated proinflammatory factors through the innate immune response involved in pathogen killing, antigen processing and immune cell survival.
Moreover, green tea EGCG application also enhanced antioxidant activity not only through its antioxidant profiles but also stimulated the production of the body's natural antioxidants in reduced inflammatory response through nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression, observed by Griess reagent and western blotting.
These results indicated that green tea EGCG may have a profound effect in reduced serum alpha1-Antitrypsin (AAT) deficiency in initiated the onset of fibromyalgia
The above differentiation was supported by the review of Chronic Inflammatory Diseases and Green Tea Polyphenol, by Dr. Helieh S. Oz at the University of Kentucky Medical Center.
According to the authors, green tea polyphenols are potent antioxidants with important roles in regulating vital signaling pathways in activated inflammatory responses by attenuated nuclear factor (NF)-kappaB IKK, NF-κB in facilitated innate- and adaptive immune responses, cell death and inflammation and cytokines like TNFα, inflammatory markers and cyclooxygenase-2 in elevated symptoms of inflammation and pain.
Dr. Helieh S., in summary, said, "green tea polyphenols (GrTPs) are potent antioxidants with important roles in regulating vital signaling pathways" and "these comprise transcription nuclear factor-kappa B mediated I kappas B kinase complex pathways, programmed cell death pathways like caspases and B-cell lymphoma-2 (through regulating the cytochrome c release from the mitochondria) and intervention with the surge of inflammatory markers like cytokines and production of cyclooxygenase-2"".
Taken together, green tea and its bioactive polyphenols may be considered as a functional food in ameliorated serum alpha1-Antitrypsin (AAT) deficiency effect in initiated the onset of fibromyalgia. However, the intake of green tea supplements should be taken with extreme care due to recent medical reports of acute liver toxicity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) alpha1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia by Blanco LE1, de Serres FJ, Fernańdez-Bustillo E, Kassam DA, Arbesú D, Rodríguez C, Torre JC.(PubMed)
(3) Chronic Inflammatory Diseases and Green Tea Polyphenols by Helieh S. Oz(PubMed Central Canada)
Thursday, October 3, 2019
Bromelain, The Natural Prevention and Treatment of Edema
Edema is a condition associated with the abnormal accumulation of fluid in certain tissues within the body.
Depending on the affected area or organs, edema can be peripheral edema or ankle edema, and pulmonary edema if the fluid is accumulated in skin ankle and lung respectively.
Traditional Chinese medicine suggested that fluid accumulation is caused by kidney dysfunction in transport the fluid coming from the pancreas to nourish other body tissues and organs.
In other words, kidney deficiency is a major cause of edema. Similar to the aforementioned condition, conventional medicine also suggested that certain kidney diseases can induce fluid retention in some parts of the body.
Furthermore, heart failure, cirrhosis of the liver, venous insufficiency are also the most common systemic diseases that cause edema, epidemiologically.
Most common risk factors associated with the risk of edema are mostly involved in the lifestyle and general health factors, including staying in one position (sitting, standing or supine) for too long, increased sodium intake and hormonal changes due to menstruation.
Some women during the course of pregnancy also experience symptoms of edema, particularly under the skin of the leg.
Furthermore, the use of medications such as Estrogen-based medication Non-steroidal anti-inflammatory drugs (NSAIDs), certain diabetes medications and medical equipment such as vasodilators has also been found to increase the risk of fluid retention.
Conventionally, the treatment of edema is totally depending on the causes of the disease. Untreated edema has been associated with the complication of skin infections or ulcerating, leading to, decreased blood circulation and increasing the risk of blood clots in the deep veins of the body.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential compound for the treatment of edema, researchers examined the Bromelain-loaded katira gum nanoparticles' effect on an animal model.
According to the tested results, the Nanoparticles of the optimized batch showed a strong anti-inflammatory activity by employing the carrageenan-induced rat paw edema method in vivo.
In other words, the anti-inflammatory activity of potential was attributed to enhanced absorption owing to reduced particle size and the protection of bromelain from acid proteases.
Moreover, according to the search of the computerized bibliographic databases Medline, EMBASE, Scopus, and CINAHL was performed on March 23, 2015, researchers found 7 studies used oral bromelain for the treatment of edema.
5/7 randomized controlled trials reported improvement postprocedure with oral bromelain compared to those of arnica,
Taken altogether, oral bromelain may be used for the treatment of edema, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature by Ho D1, Jagdeo J, Waldorf HA. (PubMed)
(2) Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles by Bernela M1, Ahuja M2, Thakur R. (PubMed)
Depending on the affected area or organs, edema can be peripheral edema or ankle edema, and pulmonary edema if the fluid is accumulated in skin ankle and lung respectively.
Traditional Chinese medicine suggested that fluid accumulation is caused by kidney dysfunction in transport the fluid coming from the pancreas to nourish other body tissues and organs.
In other words, kidney deficiency is a major cause of edema. Similar to the aforementioned condition, conventional medicine also suggested that certain kidney diseases can induce fluid retention in some parts of the body.
Furthermore, heart failure, cirrhosis of the liver, venous insufficiency are also the most common systemic diseases that cause edema, epidemiologically.
Most common risk factors associated with the risk of edema are mostly involved in the lifestyle and general health factors, including staying in one position (sitting, standing or supine) for too long, increased sodium intake and hormonal changes due to menstruation.
Some women during the course of pregnancy also experience symptoms of edema, particularly under the skin of the leg.
Furthermore, the use of medications such as Estrogen-based medication Non-steroidal anti-inflammatory drugs (NSAIDs), certain diabetes medications and medical equipment such as vasodilators has also been found to increase the risk of fluid retention.
Conventionally, the treatment of edema is totally depending on the causes of the disease. Untreated edema has been associated with the complication of skin infections or ulcerating, leading to, decreased blood circulation and increasing the risk of blood clots in the deep veins of the body.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential compound for the treatment of edema, researchers examined the Bromelain-loaded katira gum nanoparticles' effect on an animal model.
According to the tested results, the Nanoparticles of the optimized batch showed a strong anti-inflammatory activity by employing the carrageenan-induced rat paw edema method in vivo.
In other words, the anti-inflammatory activity of potential was attributed to enhanced absorption owing to reduced particle size and the protection of bromelain from acid proteases.
Moreover, according to the search of the computerized bibliographic databases Medline, EMBASE, Scopus, and CINAHL was performed on March 23, 2015, researchers found 7 studies used oral bromelain for the treatment of edema.
5/7 randomized controlled trials reported improvement postprocedure with oral bromelain compared to those of arnica,
Taken altogether, oral bromelain may be used for the treatment of edema, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature by Ho D1, Jagdeo J, Waldorf HA. (PubMed)
(2) Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles by Bernela M1, Ahuja M2, Thakur R. (PubMed)
Green Tea, The Beverage Which Blocks The Onset of Ulcerative Colitis, Researchers Find
Green tea may have a therapeutic and positive effect on prevention and treatment of Ulcerative Colitis, some scientists suggested.
Ulcerative Colitis is a digestive condition characterized by inflammatory bowel disease (IBD) that induces chronic inflammation and ulcers (sores) in the digestive tract.
According to statistics, approximately, between 250,000 and 500,000 people are infected by ulcerative colitis in the United States. The risk of ulcerative colitis onset is between 2 to 7 per 100,000 persons.
Most common symptoms are abdominal pain and diarrhea. However, some patients may also experience symptoms of fatigue or tiredness, loss of appetite, dehydration feeling the urge to empty the bowels constantly,.... and weight loss.
If you have some of the symptoms above, please check with your doctor to rule out the possibility of ulcerative colitis.
Researchers do not know the exact cause of Ulcerative Colitis.
Neither they know why ulcerative colitis induces chronic inflammation and ulcers (sores) in the digestive tract.
However, they do know that certain risk factors are associated to the development of the disease, including genetic mutation of a certain gene, environmental toxins, overreaction of the immune system,.... and long-term high levels of linoleic acid intake.
Green tea, a precious drink processes numbers of health benefits known to almost everyone in Asia and the Western world.
As yin in nature, long-term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Mild to moderate ulcerative colitis (UC) patients, 15 received 400 mg or 800 mg of total Polyphenon E daily, administered in split doses or and 4 in placebo in a double-blinded, placebo-controlled pilot study, researchers at the end of the experiential indicated that oral administration of the extracts exerts a potential effect of reduced levels of inflammation through the improvement of the reading of the mean UC disease activity index score compared to the entry score.
After 56 days of therapy, the Polyphenon E treatment group exhibited strong improvement of over-response rate of 66.7% (10 of 15) and a remission rate of 53.3% (8/15) compared to 0% (0/4) in both response rate and remission rate in the placebo group.
Dr. Dryden GW, the lead author, after taking into account of other co-founder said, "Administration of Polyphenon E resulted in a therapeutic benefit for(ulcerative colitis (UC)) patients who were refractory to 5-aminosalicylic and/or azathioprine".
Polyphenon E is high-quality tea catechin extracted from natural tea leaves.
Further analysis of green tea bioactive polyphenols, epigallocatechin gallate (EGCG) on dextran sulfate sodium- (DSS-) induced ulcerative colitis in rats and to explore the roles of TLR4/MyD88/NF-κB signaling pathway, indicated that application of the extract significantly improves the intestinal mucosal injury in rats through inhibited production of inflammatory factors which were overexpression during the acute phase of injuring and damage to induced further damage to the tissue.
Moreover, green tea bioactive polyphenols, epigallocatechin gallate (EGCG) also reduced chronic inflammation and maintained the balance of the ratio of Th1/Th2 T-helper (Th) lymphocytes that prevent alterations in cellular immunity in patients with ulcerative colitis.
Imbalance of Th1/Th2 was found to associate with the occurrence and development of ulcerative colitis.
Additionally, injection of green tea EGCG also reduced the levels of TLR4 signaling in activated the intracellular signaling pathway NF-κB and inflammatory cytokine production to imitate inflammation.
Amazingly, researchers also found that injection of TLR4 antagonism not only shows a significantly reduced the protective effect of EGCG on intestinal mucosal injury colitis but also increased the expressions of inflammatory factors in the production of pro-inflammatory cytokines.
Moreover, in the examine the antioxidant activity of green tea catechins in model of colitis induced by 2.4.6 trinitrobenzene sulfonic acid (TNBS) using 35 young adult Sprague-Dawley rats which are divided into four groups: normal control (n=5), catechins (n=9), TNBS (n=9) and 2.4.6 trinitrobenzene sulfonic acid (TNBS) plus catechins (n=12), at the end of the experiment researchers at the Joint study, American University of Beirut, found that groups with TNBS and catechin express strong anti-inflammatory and anti-oxidant effects of amelioration of symptoms and expression of ulcerative colitis through stabilizing the mast cells production, induced by injection of TNBS in compared to TNBS treated group.
Dr. the lead authors in the joint study suggested that the study depicted a significant amelioration in the TNBS- and EGCG-treated rats compared to the non-treated animals in similar to histological data, as the mechanism of action occurred basically through the NF-kB pathway and possibly through crosstalk with other pathways.
Taken together, green tea and its bioactive polyphenols may be considered as functional foods for the prevention and treatment of ulcerative colitis through the expression of antioxidant and anti-inflammatory activity.
Intake of green tea extract should be taken with extreme care as acute toxicity has been reported in some cases.
https://kylejnorton.blogspot.com/2018/09/green-tea-beverage-which-blocks-onset.html
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(1) A pilot study to evaluate the safety and efficacy of an oral dose of (-)-epigallocatechin-3-gallate-rich polyphenon E in patients with mild to moderate ulcerative colitis by Dryden GW1, Lam A, Beatty K, Qazzaz HH, McClain CJ. (PubMed)
(2) Tea catechins induce crosstalk between signaling pathways and stabilize mast cells in ulcerative colitis by Gerges Geagea A1,2, Rizzo M2, Eid A1, Hajj Hussein I3, Zgheib Z1, Zeenny MN1, Jurjus R4, Uzzo ML5, Spatola GF5, Bonaventura G5, Leone A5, Massaad-Massade L6,7,8, Jurjus A1.(PubMed)
(3) EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF-κB Signaling Pathway in Rats by TNBS,1 Liu Xuelei,2 Dong Wanwei,3 Liang Linlang,1 and Chen Keyan3(Hindawi)
Ulcerative Colitis is a digestive condition characterized by inflammatory bowel disease (IBD) that induces chronic inflammation and ulcers (sores) in the digestive tract.
According to statistics, approximately, between 250,000 and 500,000 people are infected by ulcerative colitis in the United States. The risk of ulcerative colitis onset is between 2 to 7 per 100,000 persons.
Most common symptoms are abdominal pain and diarrhea. However, some patients may also experience symptoms of fatigue or tiredness, loss of appetite, dehydration feeling the urge to empty the bowels constantly,.... and weight loss.
If you have some of the symptoms above, please check with your doctor to rule out the possibility of ulcerative colitis.
Researchers do not know the exact cause of Ulcerative Colitis.
Neither they know why ulcerative colitis induces chronic inflammation and ulcers (sores) in the digestive tract.
However, they do know that certain risk factors are associated to the development of the disease, including genetic mutation of a certain gene, environmental toxins, overreaction of the immune system,.... and long-term high levels of linoleic acid intake.
Green tea, a precious drink processes numbers of health benefits known to almost everyone in Asia and the Western world.
As yin in nature, long-term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Mild to moderate ulcerative colitis (UC) patients, 15 received 400 mg or 800 mg of total Polyphenon E daily, administered in split doses or and 4 in placebo in a double-blinded, placebo-controlled pilot study, researchers at the end of the experiential indicated that oral administration of the extracts exerts a potential effect of reduced levels of inflammation through the improvement of the reading of the mean UC disease activity index score compared to the entry score.
After 56 days of therapy, the Polyphenon E treatment group exhibited strong improvement of over-response rate of 66.7% (10 of 15) and a remission rate of 53.3% (8/15) compared to 0% (0/4) in both response rate and remission rate in the placebo group.
Dr. Dryden GW, the lead author, after taking into account of other co-founder said, "Administration of Polyphenon E resulted in a therapeutic benefit for(ulcerative colitis (UC)) patients who were refractory to 5-aminosalicylic and/or azathioprine".
Polyphenon E is high-quality tea catechin extracted from natural tea leaves.
Further analysis of green tea bioactive polyphenols, epigallocatechin gallate (EGCG) on dextran sulfate sodium- (DSS-) induced ulcerative colitis in rats and to explore the roles of TLR4/MyD88/NF-κB signaling pathway, indicated that application of the extract significantly improves the intestinal mucosal injury in rats through inhibited production of inflammatory factors which were overexpression during the acute phase of injuring and damage to induced further damage to the tissue.
Moreover, green tea bioactive polyphenols, epigallocatechin gallate (EGCG) also reduced chronic inflammation and maintained the balance of the ratio of Th1/Th2 T-helper (Th) lymphocytes that prevent alterations in cellular immunity in patients with ulcerative colitis.
Imbalance of Th1/Th2 was found to associate with the occurrence and development of ulcerative colitis.
Additionally, injection of green tea EGCG also reduced the levels of TLR4 signaling in activated the intracellular signaling pathway NF-κB and inflammatory cytokine production to imitate inflammation.
Amazingly, researchers also found that injection of TLR4 antagonism not only shows a significantly reduced the protective effect of EGCG on intestinal mucosal injury colitis but also increased the expressions of inflammatory factors in the production of pro-inflammatory cytokines.
Moreover, in the examine the antioxidant activity of green tea catechins in model of colitis induced by 2.4.6 trinitrobenzene sulfonic acid (TNBS) using 35 young adult Sprague-Dawley rats which are divided into four groups: normal control (n=5), catechins (n=9), TNBS (n=9) and 2.4.6 trinitrobenzene sulfonic acid (TNBS) plus catechins (n=12), at the end of the experiment researchers at the Joint study, American University of Beirut, found that groups with TNBS and catechin express strong anti-inflammatory and anti-oxidant effects of amelioration of symptoms and expression of ulcerative colitis through stabilizing the mast cells production, induced by injection of TNBS in compared to TNBS treated group.
Dr. the lead authors in the joint study suggested that the study depicted a significant amelioration in the TNBS- and EGCG-treated rats compared to the non-treated animals in similar to histological data, as the mechanism of action occurred basically through the NF-kB pathway and possibly through crosstalk with other pathways.
Taken together, green tea and its bioactive polyphenols may be considered as functional foods for the prevention and treatment of ulcerative colitis through the expression of antioxidant and anti-inflammatory activity.
Intake of green tea extract should be taken with extreme care as acute toxicity has been reported in some cases.
https://kylejnorton.blogspot.com/2018/09/green-tea-beverage-which-blocks-onset.html
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(1) A pilot study to evaluate the safety and efficacy of an oral dose of (-)-epigallocatechin-3-gallate-rich polyphenon E in patients with mild to moderate ulcerative colitis by Dryden GW1, Lam A, Beatty K, Qazzaz HH, McClain CJ. (PubMed)
(2) Tea catechins induce crosstalk between signaling pathways and stabilize mast cells in ulcerative colitis by Gerges Geagea A1,2, Rizzo M2, Eid A1, Hajj Hussein I3, Zgheib Z1, Zeenny MN1, Jurjus R4, Uzzo ML5, Spatola GF5, Bonaventura G5, Leone A5, Massaad-Massade L6,7,8, Jurjus A1.(PubMed)
(3) EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF-κB Signaling Pathway in Rats by TNBS,1 Liu Xuelei,2 Dong Wanwei,3 Liang Linlang,1 and Chen Keyan3(Hindawi)
Wednesday, October 2, 2019
Green Tea and its Bioactive Polyphenol EGCG in Reduced Risk, Progression and Treatment of Psoriasis and Initiation of Psoriatic Arthritis
Green tea may have a therapeutic and positive effect in reduced risk, progression and treatment of psoriasis, some scientists suggested.
Psoriasis is an immuno-inflammatory disease characterized by speeding up the life cycle of skin cells to induce skin cells to build up rapidly on the surface.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
In the investigation of green tea EGCG effect on BALB/c mice induced psoriasis by topically treated with imiquimod (IMQ) for 6 consecutive days, as a psoriasis mouse model, researchers found that application of green tea bioactive compound demonstrated a significant effect in improved psoriasiform dermatitis and the skin pathological structure by inhibited the proliferating cell nuclear antigen (PCNA) which has been found in elevated levels in patient with psoriasis.
The levels of proliferating cell nuclear antigen (PCNA) considered as a biomarker and an abnormally proliferating cell pool in patients with skin cancer was also inhibited by EGCG injection
Administration of EGCG promoted caspase-14 expression which has been altered in patients with psoriasis to orchestrate epidermal differentiation in decreased in inflammatory lesions in atopic dermatitis through its function as a novel regulator of skin cell differentiation and skin barrier formation to protect the skin cell against inflammation.
Treatment of EGCG also attenuated skin inflammation through reduced levels of inflammatory factors such as interleukin (IL)-17A, a pro-inflammatory cytokine, produced by a group of T helper cells and IL-17F a pro-inflammatory cytokine and immune mediator in trigger the innate immune activity in the acute phase of infection.
Furthermore, injection of green EGCG also inhibited the T helper (Th) cell subsets IL-22 in secreted cytokines in stimulated immune the defense against certain microbes and the development and maintenance of chronic inflammatory diseases and IL-23 in enhanced the expansion of T helper type 17 (Th17) cells which has been found to associate to prevalence of many of the inflammatory autoimmune responses, including psoriasis.
Significantly, green tea also reduced infiltrations of T cells in facilitating inflammatory skin lesions caused by the injection of imiquimod (IMQ).
Moreover, EGCG also ameliorated the production of malondialdehyde (MDA), an end product of lipid peroxidation in plasma observed by the protocol with colorimetric Diagnostic Reagent Kit an indication of overproduction of reactive oxygen species (ROS) in precipitated free radical chain reaction to induced oxidative stress caused by psoriasis through expression of its antioxidants and induced production of natural antioxidants in the body.
Importantly, the application of green tea compound increased percentages of CD4+ T cells in immunocytes in the activated a series of local immunologically mediated stimulatory events that produce further T cell activation and appearance against triggers conversion of symptomless (PN) skin into psoriatic plaques (PP skin).
Dr. Shuangshuang Zhang, the lead author after taking into account other confounder said, " (
EGCG attenuates the IMQ-induced histological changes of skin) of marked hyperkeratosis, parakeratosis, modest acanthosis, elongated rete ridges, and modest dermal inflammation...., increased parakeratosis, acanthosis and inflammatory cell infiltration (caused by IMQ)".
EGCG exerted anti-inflammatory, immune regulatory and antioxidant effects in ameliorated expression of psoriasis may also have strong implications in prevented psoriasis in the induction of chronic inflammation of the joint in catalyzed psoriatic arthritis.
Taken together, green tea and its bioactive polyphenol EGCG may be considered as a functional food for reduced risk, progression and used with conventional medicine for the treatment of psoriasis. However, the intake of green tea supplements should be taken with exceptional care as acute liver toxicity was reported in several medical literatures.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice by Shuangshuang Zhang,#1 Xiangdong Liu,#2 Lihong Mei,1 Hongfeng Wang,1 and Fang Fang(PMC)
Psoriasis is an immuno-inflammatory disease characterized by speeding up the life cycle of skin cells to induce skin cells to build up rapidly on the surface.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
In the investigation of green tea EGCG effect on BALB/c mice induced psoriasis by topically treated with imiquimod (IMQ) for 6 consecutive days, as a psoriasis mouse model, researchers found that application of green tea bioactive compound demonstrated a significant effect in improved psoriasiform dermatitis and the skin pathological structure by inhibited the proliferating cell nuclear antigen (PCNA) which has been found in elevated levels in patient with psoriasis.
The levels of proliferating cell nuclear antigen (PCNA) considered as a biomarker and an abnormally proliferating cell pool in patients with skin cancer was also inhibited by EGCG injection
Administration of EGCG promoted caspase-14 expression which has been altered in patients with psoriasis to orchestrate epidermal differentiation in decreased in inflammatory lesions in atopic dermatitis through its function as a novel regulator of skin cell differentiation and skin barrier formation to protect the skin cell against inflammation.
Treatment of EGCG also attenuated skin inflammation through reduced levels of inflammatory factors such as interleukin (IL)-17A, a pro-inflammatory cytokine, produced by a group of T helper cells and IL-17F a pro-inflammatory cytokine and immune mediator in trigger the innate immune activity in the acute phase of infection.
Furthermore, injection of green EGCG also inhibited the T helper (Th) cell subsets IL-22 in secreted cytokines in stimulated immune the defense against certain microbes and the development and maintenance of chronic inflammatory diseases and IL-23 in enhanced the expansion of T helper type 17 (Th17) cells which has been found to associate to prevalence of many of the inflammatory autoimmune responses, including psoriasis.
Significantly, green tea also reduced infiltrations of T cells in facilitating inflammatory skin lesions caused by the injection of imiquimod (IMQ).
Moreover, EGCG also ameliorated the production of malondialdehyde (MDA), an end product of lipid peroxidation in plasma observed by the protocol with colorimetric Diagnostic Reagent Kit an indication of overproduction of reactive oxygen species (ROS) in precipitated free radical chain reaction to induced oxidative stress caused by psoriasis through expression of its antioxidants and induced production of natural antioxidants in the body.
Importantly, the application of green tea compound increased percentages of CD4+ T cells in immunocytes in the activated a series of local immunologically mediated stimulatory events that produce further T cell activation and appearance against triggers conversion of symptomless (PN) skin into psoriatic plaques (PP skin).
Dr. Shuangshuang Zhang, the lead author after taking into account other confounder said, " (
EGCG attenuates the IMQ-induced histological changes of skin) of marked hyperkeratosis, parakeratosis, modest acanthosis, elongated rete ridges, and modest dermal inflammation...., increased parakeratosis, acanthosis and inflammatory cell infiltration (caused by IMQ)".
EGCG exerted anti-inflammatory, immune regulatory and antioxidant effects in ameliorated expression of psoriasis may also have strong implications in prevented psoriasis in the induction of chronic inflammation of the joint in catalyzed psoriatic arthritis.
Taken together, green tea and its bioactive polyphenol EGCG may be considered as a functional food for reduced risk, progression and used with conventional medicine for the treatment of psoriasis. However, the intake of green tea supplements should be taken with exceptional care as acute liver toxicity was reported in several medical literatures.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice by Shuangshuang Zhang,#1 Xiangdong Liu,#2 Lihong Mei,1 Hongfeng Wang,1 and Fang Fang(PMC)
Collard Greens Inhibits the Fat Accumulation in Obese Patients
Obesity is a chronic condition characterized by excess body fat that has accumulated over time. People with a BMI of over 30 is considered obese.
Similarly, overweight is a condition of excess body weight relative to height. People with a BMI ranged from 25 to 29.9 is considered overweight.
According to the statistics, 68% of the American population is either overweight or obese. Obesity has been found to induce adverse effects nearly every system of the human body, leading to an increased risk of numerous diseases, including diabetes and cardiovascular disease.
Furthermore, the rate of obesity in the US and Canada continues to climb at an alarming rate, leading to significant burdens to the country's economy and health care system.
Epidemiologically, most common symptoms of obesity are breathlessness, increased sweating, inability to cope with physical activity, feeling very tired every day, back and joint pains, low confidence, and self-esteem and feeling isolation
According to the CDC, the most common complications associated with obesity are coronary heart disease, stroke, type 2 diabetes, cancer of breast, colon, endometrial, gallbladder, kidney, and liver and sleep apnea.
Currently, there is no effective treatment of the disease. However, some researchers suggested that combat the powerful environmental factors that influence eating and physical activity may be the best approach to reduce the risk of obesity.
Bariatric surgery is used as an option for management that causes a reduction in the amount of food you are or a reduction in the absorption of calories from the food you eat, or both.
The surgery has been proposed to patients with extreme obesity (BMI of 40 or higher) due to weight-induced a serious weight-related health problem, such as diabetes or high blood pressure.
Furthermore, this type of surgery has posed a serious risk of many patients if the commitment of making lifelong changes in the eating and exercise habits cannot be followed through.
Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.
With an aim to find a natural food for the prevention and treatment of obesity, researchers examined the effect of sulforaphane found abundantly in collard greens.
In a high-fat diet (HFD)-induced obesity in C57BL/6N mice which were fed a normal diet (ND), HFD or HFD plus 0.1% sulforaphane (SFN) for 6 weeks, researchers found that SFN administration not only attenuated HFD-induced visceral adiposity that stored around a number of important internal organs such as the liver, pancreas and intestines, adipocyte hypertrophy associated with an enlargement of adipose tissue but also ameliorated fat accumulation in the liver.
Furthermore, SFN decreased the elevated levels of serum total cholesterol and leptin, and liver triglyceride in HFD-SFN-fed mice compared to HFD-fed mice.
SFN also inhibited the expression of a gene associated with the promotion of inflammation in the adipose tissue of HFD-SFN mice and increased the adiponectin function in regulating glucose levels and fatty acid breakdown.
Moreover, reductase expression associated with the production of cholesterol was decreased and an antibody associated with fatty acid utilization was increased in lycopene treat group compared with HFD-fed mice.
Taken altogether, collard green processed abundantly SFN may be considered supplements for the prevention and treatment of obesity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential effects of sulforaphane to fight obesity by Martins T1, Colaço B1,2, Venâncio C1,2, Pires MJ1,3, Oliveira PA1,3, Rosa E1, Antunes LM. (PubMed)
(2) Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice by Kyeong-Mi Choi, Youn-Sun Lee, Wonkyun Kima, Seung Jung Kimb, Kyong-Oh Shina, Ji-YeonYuc, Mi Kyeong Lee, Yong-Moon Lee, Jin Tae Honga, Yeo-PyoYuna, Hwan-SooYooa. (Science Direct)
Similarly, overweight is a condition of excess body weight relative to height. People with a BMI ranged from 25 to 29.9 is considered overweight.
According to the statistics, 68% of the American population is either overweight or obese. Obesity has been found to induce adverse effects nearly every system of the human body, leading to an increased risk of numerous diseases, including diabetes and cardiovascular disease.
Furthermore, the rate of obesity in the US and Canada continues to climb at an alarming rate, leading to significant burdens to the country's economy and health care system.
Epidemiologically, most common symptoms of obesity are breathlessness, increased sweating, inability to cope with physical activity, feeling very tired every day, back and joint pains, low confidence, and self-esteem and feeling isolation
According to the CDC, the most common complications associated with obesity are coronary heart disease, stroke, type 2 diabetes, cancer of breast, colon, endometrial, gallbladder, kidney, and liver and sleep apnea.
Currently, there is no effective treatment of the disease. However, some researchers suggested that combat the powerful environmental factors that influence eating and physical activity may be the best approach to reduce the risk of obesity.
Bariatric surgery is used as an option for management that causes a reduction in the amount of food you are or a reduction in the absorption of calories from the food you eat, or both.
The surgery has been proposed to patients with extreme obesity (BMI of 40 or higher) due to weight-induced a serious weight-related health problem, such as diabetes or high blood pressure.
Furthermore, this type of surgery has posed a serious risk of many patients if the commitment of making lifelong changes in the eating and exercise habits cannot be followed through.
Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.
With an aim to find a natural food for the prevention and treatment of obesity, researchers examined the effect of sulforaphane found abundantly in collard greens.
In a high-fat diet (HFD)-induced obesity in C57BL/6N mice which were fed a normal diet (ND), HFD or HFD plus 0.1% sulforaphane (SFN) for 6 weeks, researchers found that SFN administration not only attenuated HFD-induced visceral adiposity that stored around a number of important internal organs such as the liver, pancreas and intestines, adipocyte hypertrophy associated with an enlargement of adipose tissue but also ameliorated fat accumulation in the liver.
Furthermore, SFN decreased the elevated levels of serum total cholesterol and leptin, and liver triglyceride in HFD-SFN-fed mice compared to HFD-fed mice.
SFN also inhibited the expression of a gene associated with the promotion of inflammation in the adipose tissue of HFD-SFN mice and increased the adiponectin function in regulating glucose levels and fatty acid breakdown.
Moreover, reductase expression associated with the production of cholesterol was decreased and an antibody associated with fatty acid utilization was increased in lycopene treat group compared with HFD-fed mice.
Taken altogether, collard green processed abundantly SFN may be considered supplements for the prevention and treatment of obesity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential effects of sulforaphane to fight obesity by Martins T1, Colaço B1,2, Venâncio C1,2, Pires MJ1,3, Oliveira PA1,3, Rosa E1, Antunes LM. (PubMed)
(2) Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice by Kyeong-Mi Choi, Youn-Sun Lee, Wonkyun Kima, Seung Jung Kimb, Kyong-Oh Shina, Ji-YeonYuc, Mi Kyeong Lee, Yong-Moon Lee, Jin Tae Honga, Yeo-PyoYuna, Hwan-SooYooa. (Science Direct)
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