Antioxidants that inhibit oxidation are stable molecules produced by the host or from the dietary sources.
Free radicals are highly reactive and unstable atoms with a single electron on the outermost ring. To become stable, free radicals intercept or donate an electron from stable atoms, leading to a chain reaction that can not be stopped until all electrons on the outermost ring are paired or inhibited by antioxidants.
Oxidative stress is a result of overexpression of free radicals compared to low levels of antioxidants in the body. Over time, oxidative stress induces protein, lipid, and cellular damage, leading to cells injury and death that facilitate the onset of chronic diseases, including CVD and cancer.
However, free radicals at a moderate level are necessary for the body function, including maintaining the blood vessels in the regulation of relaxation and constriction.
Some diseases associated with free radicals are
* Cancers
Free radical-induced oxidative stress causes alteration of DNA, leading to the possible development of cancer.
* Atherosclerosis
Atherosclerosis developing is associated with the oxidation of low-density lipoprotein molecules (LDL) or bad cholesterol, that leads to damage to the arterial wall.
* Ischemia
Researchers found that free radicals generated during oxidated stress through a series of interacting pathways in cardiac myocytes and endothelial cells can lead to the increased post-ischemic heart and post-ischemic injury.
* Diabetes mellitus
Diabetes mellitus reduced the ability of the body to regulate peroxide and transition metal metabolism that result in the establishment of the disease-induced longer-term complications such as atherosclerosis, kidney, and nerve damage as well as blindness.
* Lung disease
The implication of oxygen and air pollutants induced free radical activity have become obvious as our lung is the only organs to take in oxygen from the atmosphere.
Betaxanthins are Phytochemicals in the class of red and yellow indole-derived pigments, belongings to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.
On finding a natural compound for the treatment of diseases associated with oxidative stress, researchers examined the betaxanthin's antioxidant capacity in Stenocereus pruinosus over a range of pH.
Based on the chemical analysis, the stability of betaxanthins was found to represent 89% of total betalains in yellow pitayas.
More precisely, the Maximum stability betaxanthins were observed at pH6.6, and the addition of ascorbic acid increased the half-life 1.8 times.
Additionally, betaxanthins were found to be more stable in gummies than in beverages observed by the increase of pigment retention increased in products that were stored in the dark or at low temperatures.
These results strongly suggested that betaxanthins exerted significant antioxidant activity.
Taken altogether, betaxanthins may be considered a natural antixodants against the onset of oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betaxanthins and antioxidant capacity in Stenocereus pruinosus: Stability and use in food by Rodríguez-Sánchez JA1, Cruz Y Victoria MT2, Barragán-Huerta BE. (PubMed)
Saturday, October 26, 2019
Herbal Alfalfa, A Potent and Natural Dietary Antioxidants
Herbal alfalfa may have a profound and positive effect on enhancing the expression of antioxidants in the body, some scientists suggested.
Antioxidants are stable molecules that inhibit oxidation induced by free radicals.
A free radical is a highly reactive atom with a single electron in the outer ring.
Free radicals produced in our body is a natural process derived either from essential metabolism through the processes of food intake or from external sources through directly contacting the skin or the air we breathe including exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals.
Some foods are antioxidants producers such as fruits and vegetables and whole-grain, while others such as processed meats, alcohol are radicals producers. Particularly, fats and oils can easily be oxidized if they are cooked in high heat.
In order to counter the overexpression of free radicals which add to the body's burden, our body produces enzymes antioxidants and metal carrier proteins to neutralize them before they can cause damage.
Depending on the degrees of free radical invasion, antioxidant enzymes can be categorized into first, second, third and even fourth line of defense.
Dr. O.M, in the examine the antioxidant defense wrote, "The role and effectiveness of the first-line defense antioxidants which basically include superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) is important and indispensable in the entire defense strategy of antioxidants, especially in reference to superoxide anion radical (*O2) which is perpetually generated in normal body metabolism, particularly through the mitochondrial energy production pathway (MEPP)".
The statement clearly suggested that in healthy individual antioxidant enzymes synthesized form our body is good enough to protect the body from bombardments of free radicals.
However, for people with a weakened immune system, chronic illness, dietary sources of antioxidants may be needed.
Oxidative stress is a result of the imbalance of free radicals and antioxidants in the body. The syndrome is either caused by overexpression of free radicals or depressed levels of antioxidants or both.
Oxidative stress has been found to induce widespread damage due to a set of a chain reaction auto-catalytically by free radicals that attacks the lipid bilayers of the cell walls, induces lipid, protein damage and alternation of cell DNA, leading to the onset of chronic diseases, including cancers.
Alfalfa is a flowering plant in the genus Medicago, belongings to the family Fabaceae.
The herb has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year for the treatment of high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney, and urinary tract infection, etc.
North America aboriginal has used Alfalfa seed as food, such as making bread and mush.
In reaffirming the herbal alfalfa antioxidant activity especially scavenging activity for hydroxyl radical and DPPH radical, researchers launched a study to determine whether a lyophilized aqueous extract of alfalfa or Medicago sativa L. could exert antioxidant activity against carbon tetrachloride-induced oxidative stress and liver injury in rats.
Before injecting the lyophilized aqueous extract of alfalfa, rats treated by CCl (4) showed a significant increase of serum of oxidative stress markers observed by the levels of transaminase, ALP, bilirubin, lipid profile. and liver MDA accompanied by the decline of antioxidant status in liver non-protein sulfhydryl (NP-SH); and total protein (TP) contents.
Pretreatment with alfalfa and silymarin for three weeks prior to the administration of CCl (4) significantly prevented the increase of oxidative markers by reducing the oxidative stress indicated by elevated NP-SH and TP concentration of the antioxidant liver enzyme.
Futhermore, the incidence of liver lesion induced by the injection of CCL(4) also reduced by the pretreatment of alfalfa extract.
The application of alfalfa extracts also exerted a potent scavenging activity against hydroxyl radical and DPPH radical.
These results indicated that alfalfa may be considered a novel natural antioxidant. Dr.Al-Dosari MS wrote in the final report, " alfalfa extract possesses hepatoprotective and antioxidative stress properties possibly through its antioxidant phytochemical constituents and substantiates its use in various liver disorders as a hepatoprotector".
Additionally, researchers at the University of Life Sciences in Lublin, in the testing antioxidant effect of a dietary protein-xanthophylls (PX) concentrate of alfalfa on raw meat launched an evaluation by adding the concentration in turkey diet.
The study included 120 turkeys assigned randomly assigned to 3 groups (group I-control group; group II--with 1.5% supplementation of the protein-xanthophylls (PX) concentrate; group III--with 3% supplementation of the protein-xanthophylls (PX) concentrate).
The addition of protein-xanthophylls (PX) concentration of alfalfa to a turkey diet protects the deterioration of breast and thigh meat quality.
Also, by examining the changes in color, oxymyoglobin content, TBARS, and oxidation-reduction potential values, researchers said " the inclusion of the concentration to turkey diets acts as an antioxidant in the raw meat.
Taken altogether, alfalfa may be considered a natural antioxidant which improves the antioxidant profile in the body against the overexpression of free radicals in the initiation of oxidative stress.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1). In vitro and in vivo antioxidant activity of alfalfa (Medicago sativa L.) on carbon tetrachloride intoxicated rats. by Al-Dosari MS (PubMed).
(2). Effect of protein-xanthophylls (PX) concentrate of alfalfa supplementation on physico-chemical properties of turkey breast and thigh muscles during ageing. by Karwowska M, Stadnik J, Dolatowski ZJ, Grela ER. (PubMed)
(3) First line defense antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defense grid by O.M.Ighodaroab, O.A.Akinloyeb. (Science Direct)
Antioxidants are stable molecules that inhibit oxidation induced by free radicals.
A free radical is a highly reactive atom with a single electron in the outer ring.
Free radicals produced in our body is a natural process derived either from essential metabolism through the processes of food intake or from external sources through directly contacting the skin or the air we breathe including exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals.
Some foods are antioxidants producers such as fruits and vegetables and whole-grain, while others such as processed meats, alcohol are radicals producers. Particularly, fats and oils can easily be oxidized if they are cooked in high heat.
In order to counter the overexpression of free radicals which add to the body's burden, our body produces enzymes antioxidants and metal carrier proteins to neutralize them before they can cause damage.
Depending on the degrees of free radical invasion, antioxidant enzymes can be categorized into first, second, third and even fourth line of defense.
Dr. O.M, in the examine the antioxidant defense wrote, "The role and effectiveness of the first-line defense antioxidants which basically include superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) is important and indispensable in the entire defense strategy of antioxidants, especially in reference to superoxide anion radical (*O2) which is perpetually generated in normal body metabolism, particularly through the mitochondrial energy production pathway (MEPP)".
The statement clearly suggested that in healthy individual antioxidant enzymes synthesized form our body is good enough to protect the body from bombardments of free radicals.
However, for people with a weakened immune system, chronic illness, dietary sources of antioxidants may be needed.
Oxidative stress is a result of the imbalance of free radicals and antioxidants in the body. The syndrome is either caused by overexpression of free radicals or depressed levels of antioxidants or both.
Oxidative stress has been found to induce widespread damage due to a set of a chain reaction auto-catalytically by free radicals that attacks the lipid bilayers of the cell walls, induces lipid, protein damage and alternation of cell DNA, leading to the onset of chronic diseases, including cancers.
Alfalfa is a flowering plant in the genus Medicago, belongings to the family Fabaceae.
The herb has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year for the treatment of high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney, and urinary tract infection, etc.
North America aboriginal has used Alfalfa seed as food, such as making bread and mush.
In reaffirming the herbal alfalfa antioxidant activity especially scavenging activity for hydroxyl radical and DPPH radical, researchers launched a study to determine whether a lyophilized aqueous extract of alfalfa or Medicago sativa L. could exert antioxidant activity against carbon tetrachloride-induced oxidative stress and liver injury in rats.
Before injecting the lyophilized aqueous extract of alfalfa, rats treated by CCl (4) showed a significant increase of serum of oxidative stress markers observed by the levels of transaminase, ALP, bilirubin, lipid profile. and liver MDA accompanied by the decline of antioxidant status in liver non-protein sulfhydryl (NP-SH); and total protein (TP) contents.
Pretreatment with alfalfa and silymarin for three weeks prior to the administration of CCl (4) significantly prevented the increase of oxidative markers by reducing the oxidative stress indicated by elevated NP-SH and TP concentration of the antioxidant liver enzyme.
Futhermore, the incidence of liver lesion induced by the injection of CCL(4) also reduced by the pretreatment of alfalfa extract.
The application of alfalfa extracts also exerted a potent scavenging activity against hydroxyl radical and DPPH radical.
These results indicated that alfalfa may be considered a novel natural antioxidant. Dr.Al-Dosari MS wrote in the final report, " alfalfa extract possesses hepatoprotective and antioxidative stress properties possibly through its antioxidant phytochemical constituents and substantiates its use in various liver disorders as a hepatoprotector".
Additionally, researchers at the University of Life Sciences in Lublin, in the testing antioxidant effect of a dietary protein-xanthophylls (PX) concentrate of alfalfa on raw meat launched an evaluation by adding the concentration in turkey diet.
The study included 120 turkeys assigned randomly assigned to 3 groups (group I-control group; group II--with 1.5% supplementation of the protein-xanthophylls (PX) concentrate; group III--with 3% supplementation of the protein-xanthophylls (PX) concentrate).
The addition of protein-xanthophylls (PX) concentration of alfalfa to a turkey diet protects the deterioration of breast and thigh meat quality.
Also, by examining the changes in color, oxymyoglobin content, TBARS, and oxidation-reduction potential values, researchers said " the inclusion of the concentration to turkey diets acts as an antioxidant in the raw meat.
Taken altogether, alfalfa may be considered a natural antioxidant which improves the antioxidant profile in the body against the overexpression of free radicals in the initiation of oxidative stress.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1). In vitro and in vivo antioxidant activity of alfalfa (Medicago sativa L.) on carbon tetrachloride intoxicated rats. by Al-Dosari MS (PubMed).
(2). Effect of protein-xanthophylls (PX) concentrate of alfalfa supplementation on physico-chemical properties of turkey breast and thigh muscles during ageing. by Karwowska M, Stadnik J, Dolatowski ZJ, Grela ER. (PubMed)
(3) First line defense antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defense grid by O.M.Ighodaroab, O.A.Akinloyeb. (Science Direct)
Herbal Aloe Vera Gobbles Up Cancer Cells in Vivo and Vitro
Aloe Vera may be the next target for the pharmaceutical companies to extract a single ingredient for the treatment of cancers, some scientists suggested.
Cancers are a class of medical diseases associated with cell growth irregularly and disorderly in some specific tissue and organs.
Most cancer starts at the cell on the surface of the inner lining of the organ's tissue. At the later stage, cancer cells can be found in the deeper of layers of the infected organ.
In the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy tissue and organ through the circulation of fluids and blood.
The causes of cancer are the results of the alternation of healthy cell DNA. Researchers do not why the healthy cell' DNA is alternated.
Normally, healthy cells undergo a certain number of cell cycle divisions than die. In a cancerous cell, cell division undergoes indefinitely.
According to the statistic, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.
The genetic mutation of the cancer cell may be associated with certain risk factors. Epidemiological studies suggested that long-term exposure to carcinogens, the increased in age, gender, inherited genetic defects and skin type can increase the risk the cancer onset.
Most common and general symptoms of cancer are unintended weight loss, lump, fatigue, loss of appetite and persistent localized symptoms and localized pain in the later stage.
If you experience some of the above symptoms, please check with your doctor right the way to rule out the possibility of cancer.
Out of numbers of the risk factor, the genetic preposition has been under intensive studied by many scientists.
Dr. Eric T, the lead author on the study of genetic implication on the cancer risk said, "Genetic testing for inherited cancer risk is now widely used to target individuals for screening and prevention" and
"Overall, 17,340 PVs were identified in 17,000 (6.7%) of the tested individuals. The pathogenic variants (PV) positive rate was 9.8% among individuals with a personal cancer history, compared to 4.7% in unaffected individuals. PVs were most common in BRCA1/2 (42.2%), other breast cancer (BR) genes (32.9%), and the LS genes (13.2%)".
These results clearly stated that people who carry certain mutated genes are at the substantial risk of cancer onset, compared to those who do not.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.
Aloe vera has been used in herbal medicine in treating many kinds of diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc.
It is also one of many popular herbs studied in scientific ways with some conflicting results.
The ten main areas of chemical constituents of Aloe vera are amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.
In the finding, a natural ingredient for the treatment of breast cancer without inducing side effects, researchers at the National Chung Hsing University conducted a study to compare the efficacy of Emodin and Aloe-Emodin, the major bioactive compound found in herbal Aloe Vera.
By analyzing the estrogenic activity as phytoestrogens on the estrogen receptor α (ER α ) activation and breast cancer cell growth, application of both emodin and aloe-emodin are capable of inhibiting breast cancer cell proliferation by reducing the ER α protein levels which has been found in high levels in patient with breast cancer thereby suppressing ER α transcriptional (mRNA) activation..
High expression of ERα mRNA is found associated with patients with breast cancer.
Breast cancer treatment with aloe-emodin also decreases the expression of the levels of ERα associated with the protein that stimulates the division of breast cancer cells by increasing the cancer cell's degradation.
The efficacy of aloe-emodin inhibited breast cancer proliferation and induced apoptosis is attributed to breaking down the cytoplasm of ER α protein in the breast cancer cells.
The results suggested that aloe-emodin suppressed breast cell proliferation emodin by targeting ER α protein expression through distinct mechanisms.
Further demonstration of the effect of aloe-emodin on the risk of cancer, researchers examined whether aloe-emodin exerts a similar effect on the growth of human cervical cancer cells, HeLa.
Human cervical cancer cells, HeLa used in the experiment were treated by different doses of aloe-emodin for 1-5 days,.
Measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay, aloe-emodin displays significant effects in the inhibition of the growth of HeLa cells in a dose-dependent manner at concentrations ranging between 2.5 and 40 micromol/L.
Aloe-emodin induces HeLa cells death by disrupting the cell cycle division at the G2/M phase, according to the flow cytometric analysis.
The effects of aloe-emodin inhibited the human by increasing the expression of proteins associated with cell death programming and reducing the expression of proteins associated with cancer prefiltration and survival.
Most importantly, after taking into account co and confounders, researchers discovered, aloe-emodin also activates the enzyme associated with the break down the protein of ER α and deactivates the enzyme associated with cell proliferation
Taken altogether, Aloe vera with the abundant aloe-emodin may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for treatment of cancer without inducing adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(2) Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition.
Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, Lin H.(PubMed)
(3) Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin. by Guo J, Xiao B, Zhang S, Liu D, Liao Y, Sun Q.(PubMed)
(4) Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation. by Guo JM, Xiao BX, Liu Q, Zhang S, Liu DH, Gong ZH.(PubMed)
(5) Clinical testing with a panel of 25 genes associated with increased cancer risk results in a significant increase in clinically significant findings across a broad range of cancer histories by (Research Gate)
Cancers are a class of medical diseases associated with cell growth irregularly and disorderly in some specific tissue and organs.
Most cancer starts at the cell on the surface of the inner lining of the organ's tissue. At the later stage, cancer cells can be found in the deeper of layers of the infected organ.
In the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy tissue and organ through the circulation of fluids and blood.
The causes of cancer are the results of the alternation of healthy cell DNA. Researchers do not why the healthy cell' DNA is alternated.
Normally, healthy cells undergo a certain number of cell cycle divisions than die. In a cancerous cell, cell division undergoes indefinitely.
According to the statistic, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.
The genetic mutation of the cancer cell may be associated with certain risk factors. Epidemiological studies suggested that long-term exposure to carcinogens, the increased in age, gender, inherited genetic defects and skin type can increase the risk the cancer onset.
Most common and general symptoms of cancer are unintended weight loss, lump, fatigue, loss of appetite and persistent localized symptoms and localized pain in the later stage.
If you experience some of the above symptoms, please check with your doctor right the way to rule out the possibility of cancer.
Out of numbers of the risk factor, the genetic preposition has been under intensive studied by many scientists.
Dr. Eric T, the lead author on the study of genetic implication on the cancer risk said, "Genetic testing for inherited cancer risk is now widely used to target individuals for screening and prevention" and
"Overall, 17,340 PVs were identified in 17,000 (6.7%) of the tested individuals. The pathogenic variants (PV) positive rate was 9.8% among individuals with a personal cancer history, compared to 4.7% in unaffected individuals. PVs were most common in BRCA1/2 (42.2%), other breast cancer (BR) genes (32.9%), and the LS genes (13.2%)".
These results clearly stated that people who carry certain mutated genes are at the substantial risk of cancer onset, compared to those who do not.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.
Aloe vera has been used in herbal medicine in treating many kinds of diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc.
It is also one of many popular herbs studied in scientific ways with some conflicting results.
The ten main areas of chemical constituents of Aloe vera are amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.
In the finding, a natural ingredient for the treatment of breast cancer without inducing side effects, researchers at the National Chung Hsing University conducted a study to compare the efficacy of Emodin and Aloe-Emodin, the major bioactive compound found in herbal Aloe Vera.
By analyzing the estrogenic activity as phytoestrogens on the estrogen receptor α (ER α ) activation and breast cancer cell growth, application of both emodin and aloe-emodin are capable of inhibiting breast cancer cell proliferation by reducing the ER α protein levels which has been found in high levels in patient with breast cancer thereby suppressing ER α transcriptional (mRNA) activation..
High expression of ERα mRNA is found associated with patients with breast cancer.
Breast cancer treatment with aloe-emodin also decreases the expression of the levels of ERα associated with the protein that stimulates the division of breast cancer cells by increasing the cancer cell's degradation.
The efficacy of aloe-emodin inhibited breast cancer proliferation and induced apoptosis is attributed to breaking down the cytoplasm of ER α protein in the breast cancer cells.
The results suggested that aloe-emodin suppressed breast cell proliferation emodin by targeting ER α protein expression through distinct mechanisms.
Further demonstration of the effect of aloe-emodin on the risk of cancer, researchers examined whether aloe-emodin exerts a similar effect on the growth of human cervical cancer cells, HeLa.
Human cervical cancer cells, HeLa used in the experiment were treated by different doses of aloe-emodin for 1-5 days,.
Measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay, aloe-emodin displays significant effects in the inhibition of the growth of HeLa cells in a dose-dependent manner at concentrations ranging between 2.5 and 40 micromol/L.
Aloe-emodin induces HeLa cells death by disrupting the cell cycle division at the G2/M phase, according to the flow cytometric analysis.
The effects of aloe-emodin inhibited the human by increasing the expression of proteins associated with cell death programming and reducing the expression of proteins associated with cancer prefiltration and survival.
Most importantly, after taking into account co and confounders, researchers discovered, aloe-emodin also activates the enzyme associated with the break down the protein of ER α and deactivates the enzyme associated with cell proliferation
Taken altogether, Aloe vera with the abundant aloe-emodin may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for treatment of cancer without inducing adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(2) Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition.
Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, Lin H.(PubMed)
(3) Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin. by Guo J, Xiao B, Zhang S, Liu D, Liao Y, Sun Q.(PubMed)
(4) Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation. by Guo JM, Xiao BX, Liu Q, Zhang S, Liu DH, Gong ZH.(PubMed)
(5) Clinical testing with a panel of 25 genes associated with increased cancer risk results in a significant increase in clinically significant findings across a broad range of cancer histories by (Research Gate)
Herbal Andrographis Modulates Immune Function To the Body Needs, Scientists Say
Herbal Andrographis paniculata may have a profound effect in enhancing the function of the immune system against disease development, some studies found.
The immune system is a set of cells that have a unique function to protect our body against antigens or infectious agents that comprises the body's defense system against diseases.
The immune system does a great job of keeping people healthy and preventing infections.
It is made of special cells (white blood cells), antibodies, tissues (bone marrow), and organs (the spleen) defend people against germs and microorganisms every day.
There are 3 types of immunity can be classified as the following
* The innate immunity is also known as natural immunity that every human born with.
* The adaptive immunity is the type of immunity that develops in the life of the individual.
* Passive immunity that borrows from the outside sources and can only last only a short period of time
There are 2 types of immune disorders
* Underactive immunity or immune deficiency. People with an underactive immune system are easy
to be infected or sick all the times
* Overactive immune system or autoimmune diseases. In this case, the immune system attacks the host tissue, causing autoimmune diseases such as rheumatoid arthritis (RA).
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.
The plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chickenpox, etc.
In finding a natural ingredient or formula for the treatment of immune dysfunction with no side effects, researchers at the Prin. K. M. Kundnani College of Pharmacy, launched an investigation to examine the immunomodulatory activity of HN-02, an extract containing a mixture of andrographolides.
The pure powder form of the mixture of andrographolides.was evaluated at 1.0, 1.5, and 2.5 mg/kg on different in vivo and in vitro experimental models.
Application of the mixture delayed-type hypersensitivity (DTH) caused by the injection of cyclophosphamide (CYP) in the mouse model.
Where cyclophosphamide (CP) is a medication used as chemotherapy and to suppress the immune system.
HN-02 treatment elevated the depressed hemagglutination antibody (HA) titer, the antibody and increased the number of plaque-forming cells (PFCs) in the spleen cells of mice caused by the injection of CYP.
HN-02 treatment stimulated phagocytosis in the immune system and increased levels of white blood cells in the tested mice.
These results strongly indicated HN-02 has the ability to enhance immune function by modulating the immune responses which were altered during antigen interaction and reversing the immunosuppression induced by CYP.
Furthermore, according to the Amala Cancer Research Centre in the examine the natural whole herb function in the modulation of immune responses against tumor cells, Andrographis paniculata extract (APE) and its isolated compound andrographolide (ANDLE) exert a clinically significant effect on cell-mediated immune responses in normal and tumor-bearing control animals.
Treatment with APE and ANDLE significantly enhanced natural killer cell activity in normal and tumor-bearing animals on the fifth day,
Antibody-dependent cellular cytotoxicity was also increased in APE as well as ANDLE on day 11-treated normal and tumor-bearing animals compared to untreated tumor-bearing control animals.
Moreover, treatment of APE and ANDLE significantly elevated the production of interleukin-2 which regulates the activities of white blood cells (leukocytes, often lymphocytes) and interferon-gamma which is critical for innate and adaptive immunity in normal and Ehrlich ascites carcinoma-bearing animals.
These results firmly indicated that herbal Andrographis may be considered functional food in the enhancement of the immune function against foreign stimuli and micro pathogens.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata by Naik SR, Hule A.(PubMed)
(2) Modulation of natural killer cell activity, antibody-dependent cellular cytotoxicity, and antibody-dependent complement-mediated cytotoxicity by andrographolide in normal and Ehrlich ascites carcinoma-bearing mice by Sheeja K, Kuttan G.(PubMed)
(3) Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo by Andrographis paniculata extract and andrographolide by Sheeja K, Kuttan G.(PubMed)
The immune system is a set of cells that have a unique function to protect our body against antigens or infectious agents that comprises the body's defense system against diseases.
The immune system does a great job of keeping people healthy and preventing infections.
It is made of special cells (white blood cells), antibodies, tissues (bone marrow), and organs (the spleen) defend people against germs and microorganisms every day.
There are 3 types of immunity can be classified as the following
* The innate immunity is also known as natural immunity that every human born with.
* The adaptive immunity is the type of immunity that develops in the life of the individual.
* Passive immunity that borrows from the outside sources and can only last only a short period of time
There are 2 types of immune disorders
* Underactive immunity or immune deficiency. People with an underactive immune system are easy
to be infected or sick all the times
* Overactive immune system or autoimmune diseases. In this case, the immune system attacks the host tissue, causing autoimmune diseases such as rheumatoid arthritis (RA).
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.
The plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chickenpox, etc.
In finding a natural ingredient or formula for the treatment of immune dysfunction with no side effects, researchers at the Prin. K. M. Kundnani College of Pharmacy, launched an investigation to examine the immunomodulatory activity of HN-02, an extract containing a mixture of andrographolides.
The pure powder form of the mixture of andrographolides.was evaluated at 1.0, 1.5, and 2.5 mg/kg on different in vivo and in vitro experimental models.
Application of the mixture delayed-type hypersensitivity (DTH) caused by the injection of cyclophosphamide (CYP) in the mouse model.
Where cyclophosphamide (CP) is a medication used as chemotherapy and to suppress the immune system.
HN-02 treatment elevated the depressed hemagglutination antibody (HA) titer, the antibody and increased the number of plaque-forming cells (PFCs) in the spleen cells of mice caused by the injection of CYP.
HN-02 treatment stimulated phagocytosis in the immune system and increased levels of white blood cells in the tested mice.
These results strongly indicated HN-02 has the ability to enhance immune function by modulating the immune responses which were altered during antigen interaction and reversing the immunosuppression induced by CYP.
Furthermore, according to the Amala Cancer Research Centre in the examine the natural whole herb function in the modulation of immune responses against tumor cells, Andrographis paniculata extract (APE) and its isolated compound andrographolide (ANDLE) exert a clinically significant effect on cell-mediated immune responses in normal and tumor-bearing control animals.
Treatment with APE and ANDLE significantly enhanced natural killer cell activity in normal and tumor-bearing animals on the fifth day,
Antibody-dependent cellular cytotoxicity was also increased in APE as well as ANDLE on day 11-treated normal and tumor-bearing animals compared to untreated tumor-bearing control animals.
Moreover, treatment of APE and ANDLE significantly elevated the production of interleukin-2 which regulates the activities of white blood cells (leukocytes, often lymphocytes) and interferon-gamma which is critical for innate and adaptive immunity in normal and Ehrlich ascites carcinoma-bearing animals.
These results firmly indicated that herbal Andrographis may be considered functional food in the enhancement of the immune function against foreign stimuli and micro pathogens.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata by Naik SR, Hule A.(PubMed)
(2) Modulation of natural killer cell activity, antibody-dependent cellular cytotoxicity, and antibody-dependent complement-mediated cytotoxicity by andrographolide in normal and Ehrlich ascites carcinoma-bearing mice by Sheeja K, Kuttan G.(PubMed)
(3) Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo by Andrographis paniculata extract and andrographolide by Sheeja K, Kuttan G.(PubMed)
Friday, October 25, 2019
Herbal Alfalfa, the Potent Remedy for the treatment of Symptoms and Diseases Associated with Estrogen Deficiency
Herbal Alfalfa may process an estrogenic effect for the treatment of estrogen-deficient diseases and symptoms, some studies found.
The estrogenic effect is an action that stimulates the production of the hormone estrogen in case of deficiency.
Menopause symptoms are a set of symptoms caused by the gradual decline of levels of estrogen and progesterone due to aging loss menstrual period in women.
The reproductive tract, the urinary tract, the heart and blood vessels, bones, breasts, skin, hair, mucous membranes, pelvic muscles normally regulated by hormone estrogen also are affected by the decline levels of the hormone.
In the concern of hormone therapy used for the treatment of menopause symptoms, herbal medicine with estrogenic effect have been under intensive investigation, with an aim to find a natural ingredient with the similar effects as of those used in hormone therapy with no side effects.
Dr. the lead scientist at the Pan-American Health Organization/World Health Organization Collaborating Centre for Traditional Medicine launched an evaluation to examine the estrogenic activity of seventeen plant species collected and extracted in Costa Rica.
Interestingly, only 6 of the plant extracts bound to the ERs with 4 of the six extracts stimulated reporter gene expression, according to the ER-beta-Chemically Activated Luciferase Expression assay.
Four extracts exerted estrogenic activity also act as estrogen agonists.
In other words, these extracts induced the production of estrogen when the body needs and inhibited levels of estrogen when the hormone is overexpressed in the body.
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae.
The herbal plant has been cultivated all over the world as hay for cattle feeding.
The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance the digestive system, bleeding disorder, kidney, and urinary tract infection, etc.
North America aboriginal has used Alfalfa seed as food, such as making bread and mush.
The chemical constituents of alfalfa include flavones, isoflavones, sterols, Bichanin A, Coumestrol Diadzein, Formonetin, Genistein, and coumarin derivatives, etc.
A study to determine whether estrogenic botanical supplement (EBS) use influences breast cancer survivors' health-related outcomes.was conducted by the research team at the Beckman Research Institute.
The study includes 767 breast cancer survivors who filled out the returned questionnaire suggested that EBS improve quality of life by reducing some of the symptom associated with 15 hormone-related symptoms such as hot flashes and night sweats.
However, Dr. Ma H, the lead author after taking into account co and confounders said, "Our findings indicate that several specific types of EBS might have important influences on a woman's various aspects of quality of life".
Additionally, in the study to clarify the effect of phytoestrogens is a group of lipophilic plant compounds, researchers launched an investigation to examine examined the proliferative effects of phytoestrogens on a rat pituitary tumor cell line, GH3/B6/F10, originally subcloned from GH3 cells based on its ability to express high levels of the membrane estrogen receptor-alpha.
The phytoestrogen compounds included in the study at the range of different concentrations are coumestrol, daidzein, genistein, and trans-resveratrol.
All four phytoestrogens attenuated the proliferative effects of estradiol when administered simultaneously.
Except for trans-resveratrol, all phytoestrogens increased GH3/B6/F10 cell proliferation at some concentration relevant to dietary levels.
All phytoestrogens exerted significant anti-proliferative activity, but with time course patterns that often differed from that of estradiol and each other.
More importantly, except for trans-resveratrol, a serum removal-induced extrinsic apoptotic pathway was blocked by these phytoestrogens.
These results clearly suggested, injection of single ingredients of phytochemicals may both tumorigenic and anti-tumorigenic effects and intake of the estrogenic whole food which processed all the ingredient exerted a strong anti-tumorigenic activity.
Taken all together, there is no doubt that herbal Alfalfa processed a strong estrogenic effect may be considered a functional food for the treatment of diseases and symptoms associated with estrogen deficiency.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Drug-induced lupus: an update by Vasoo S.(PubMed)
(2) Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL study report by Ma H, Sullivan-Halley J, Smith AW, Neuhouser ML, Alfano CM, Meeske K, George SM, McTiernan A, McKean-Cowdin R, Baumgartner KB, Ballard-Barbash R, Bernstein L.(PubMed)
(3) Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10 cells - the involvement of rapidly activated kinases and caspases by Jeng YJ, Watson CS.(PubMed)
The estrogenic effect is an action that stimulates the production of the hormone estrogen in case of deficiency.
Menopause symptoms are a set of symptoms caused by the gradual decline of levels of estrogen and progesterone due to aging loss menstrual period in women.
The reproductive tract, the urinary tract, the heart and blood vessels, bones, breasts, skin, hair, mucous membranes, pelvic muscles normally regulated by hormone estrogen also are affected by the decline levels of the hormone.
In the concern of hormone therapy used for the treatment of menopause symptoms, herbal medicine with estrogenic effect have been under intensive investigation, with an aim to find a natural ingredient with the similar effects as of those used in hormone therapy with no side effects.
Dr. the lead scientist at the Pan-American Health Organization/World Health Organization Collaborating Centre for Traditional Medicine launched an evaluation to examine the estrogenic activity of seventeen plant species collected and extracted in Costa Rica.
Interestingly, only 6 of the plant extracts bound to the ERs with 4 of the six extracts stimulated reporter gene expression, according to the ER-beta-Chemically Activated Luciferase Expression assay.
Four extracts exerted estrogenic activity also act as estrogen agonists.
In other words, these extracts induced the production of estrogen when the body needs and inhibited levels of estrogen when the hormone is overexpressed in the body.
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae.
The herbal plant has been cultivated all over the world as hay for cattle feeding.
The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance the digestive system, bleeding disorder, kidney, and urinary tract infection, etc.
North America aboriginal has used Alfalfa seed as food, such as making bread and mush.
The chemical constituents of alfalfa include flavones, isoflavones, sterols, Bichanin A, Coumestrol Diadzein, Formonetin, Genistein, and coumarin derivatives, etc.
A study to determine whether estrogenic botanical supplement (EBS) use influences breast cancer survivors' health-related outcomes.was conducted by the research team at the Beckman Research Institute.
The study includes 767 breast cancer survivors who filled out the returned questionnaire suggested that EBS improve quality of life by reducing some of the symptom associated with 15 hormone-related symptoms such as hot flashes and night sweats.
However, Dr. Ma H, the lead author after taking into account co and confounders said, "Our findings indicate that several specific types of EBS might have important influences on a woman's various aspects of quality of life".
Additionally, in the study to clarify the effect of phytoestrogens is a group of lipophilic plant compounds, researchers launched an investigation to examine examined the proliferative effects of phytoestrogens on a rat pituitary tumor cell line, GH3/B6/F10, originally subcloned from GH3 cells based on its ability to express high levels of the membrane estrogen receptor-alpha.
The phytoestrogen compounds included in the study at the range of different concentrations are coumestrol, daidzein, genistein, and trans-resveratrol.
All four phytoestrogens attenuated the proliferative effects of estradiol when administered simultaneously.
Except for trans-resveratrol, all phytoestrogens increased GH3/B6/F10 cell proliferation at some concentration relevant to dietary levels.
All phytoestrogens exerted significant anti-proliferative activity, but with time course patterns that often differed from that of estradiol and each other.
More importantly, except for trans-resveratrol, a serum removal-induced extrinsic apoptotic pathway was blocked by these phytoestrogens.
These results clearly suggested, injection of single ingredients of phytochemicals may both tumorigenic and anti-tumorigenic effects and intake of the estrogenic whole food which processed all the ingredient exerted a strong anti-tumorigenic activity.
Taken all together, there is no doubt that herbal Alfalfa processed a strong estrogenic effect may be considered a functional food for the treatment of diseases and symptoms associated with estrogen deficiency.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Drug-induced lupus: an update by Vasoo S.(PubMed)
(2) Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL study report by Ma H, Sullivan-Halley J, Smith AW, Neuhouser ML, Alfano CM, Meeske K, George SM, McTiernan A, McKean-Cowdin R, Baumgartner KB, Ballard-Barbash R, Bernstein L.(PubMed)
(3) Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10 cells - the involvement of rapidly activated kinases and caspases by Jeng YJ, Watson CS.(PubMed)
Herbal Aloe Vera, The Potential Cure of Gastric Ulcer With No Side Effects
Scientists may have found a natural herbal medicine for the treatment of gastric ulcer without inducing any side effects, some studies suggested.
Gastric ulcer is the medical condition characterized by the open sores that develop on the inside lining of the stomach. If the open sores are developed in the upper part of the small intestine, it is a duodenal ulcer.
Most common cause of the gastric ulcer, represented over 30% of all cases is associated with the infection of H. pylori.
Certain medical conditions such as Zollinger-Ellison syndrome and long-term use of some medication such as alendronate (Fosamax) and risedronate (Actonel) are also the prevalent risk factors that elevate the disease onset.
Most common symptoms of a gastric ulcer are gastrointestinal discomforts, blood in your stool, difficulty breathing, shortness of breath with physical activity, and persistent fatigue.
Some patients with a severe gastric ulcers may also experience symptoms of vomiting blood, feeling faint or losing consciousness. However, 75% of patients with gastric ulcers do not feel any symptoms.
If you have some of the above symptoms, please make that you check with your doctor to rule out the possibility of the condition.
Treatment of gastric ulcer is totally depending on the causes, such as histamine receptor blockers (H2 blockers) or proton pump inhibitors (PPIs) for patients with gastric ulcers induced by overproduction of stomach acid and the antibiotics for the infection caused by H. pylori.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan.
The herb has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc.
It is also one of many popular herbs studied in scientific ways with some conflicting results.
The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols. All ingredients work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.
In the study to examine the effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels, and gastric ulcer healing in 48 Male Spraque-Dawley rat divided into four groups as the following, group1 served a as control group, group 2 as gastric ulcer group without treatment, groups 3 and 4 as gastric ulcer treatment groups with sucralfate and Aloe vera, researchers found
* On day 1 after induction of gastric ulcer and before treatment the leukocyte adherence in postcapillary venule was significantly increased in the ulcer groups, an indication of the immune response to the gastric damage when compared to the control group. The level of TNF-alpha was elevated and the level of IL-10 was reduced, an indication of overexpression of pro-inflammatory cytokines.
* In the ulcer groups treated with sucralfate and Aloe vera, leukocyte adherence was reduced in postcapillary venule. The level of IL-10 was elevated, but the level of TNF-. alpha had no significant difference, an indication of the leading process with the presence of anti-inflammatory cytokine.
* On day 8, the leukocyte adherence in postcapillary venule and the level of TNF-alpha were still increased and the level of IL-10 was reduced in the ulcer group without treatment.
Dr. Eamlamnam K, the lead scientist at the final days of the study, wrote, "histopathological examination of the stomach on days 1 and 8 after induction of gastric ulcer showed that gastric tissue was damaged with inflammation. In the ulcer groups treated with sucralfate and Aloe vera on days 1 and 8, gastric inflammation was reduced, epithelial cell proliferation was enhanced and gastric glands became elongated".
The results further confirm the efficacy of Aloe vera in promoting gastric ulcer healing, through the expressions of leukocyte adherence and TNF-alpha level, elevate IL-10 level.
Additionally, in the examination of the anti-inflammatory effects of Aloe vera on leukocyte-endothelium in the gastric microcirculation of Helicobacter pylori (H. pylori)-infected of 36 male Sprague-Dawley rats divided into 3 groups: control, H. pylori-infected, and A. vera-treated group (200 mg/kg b.w., twice daily). researchers found that
* H. pylori-infected group shows a significant increase of the leukocyte adhesion cells and the TNF-alpha level compared with the control group on day 8.
* After treatment with A. vera H. pylori-infected group exerts a reduced leukocyte adhesion and TNF-alpha significantly.
Dr. Prabjone R, the lead author at the final conclusion said, "enhancement in leukocyte-endothelium interaction could be improved by the treatment of A. vera, associated with the reduction in TNF-alpha level".
Interestingly, in the acute gastric mucosal lesions induced by 0.6 M HCl and acid output Aloe vera endowed with gastric acid anti-secretory activity were found to protect the gastric mucosa at low concentrations against injurious agents. Its bioactive component, the Polymer fraction reduces 50% of the mRNA expressions of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS) in the initiation of the pathogenesis of inflammation.
Taken altogether, herbal Aloe vera may be considered a functional food for the prevention and treatment of gastric ulcer without inducing any side effects.
However, due to the limitation of the above studies, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of herbal Aloe vera anti-gastric ulcers possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(2) Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats, by Eamlamnam K, Patumraj S, Visedopas N, Thong-Ngam D.(PubMed)
(3) The effect of Aloe vera A. Berger (Liliaceae) on gastric acid secretion and acute gastric mucosal injury in rats by Yusuf S, Agunu A, Diana M.(PubMed)(4) Anti-inflammatory effects of Aloe vera on leukocyte-endothelium interaction in the gastric microcirculation of Helicobacter pylori-infected rats by Prabjone R, Thong-Ngam D, Wisedopas N, Chatsuwan T, Patumraj S.(PubMed)
(5) Polymer fraction of Aloe vera exhibits a protective activity on ethanol-induced gastric lesions.
Park CH, Nam DY, Son HU, Lee SR, Lee HJ, Heo JC, Cha TY, Baek JH, Lee SH.(PubMed)
Gastric ulcer is the medical condition characterized by the open sores that develop on the inside lining of the stomach. If the open sores are developed in the upper part of the small intestine, it is a duodenal ulcer.
Most common cause of the gastric ulcer, represented over 30% of all cases is associated with the infection of H. pylori.
Certain medical conditions such as Zollinger-Ellison syndrome and long-term use of some medication such as alendronate (Fosamax) and risedronate (Actonel) are also the prevalent risk factors that elevate the disease onset.
Most common symptoms of a gastric ulcer are gastrointestinal discomforts, blood in your stool, difficulty breathing, shortness of breath with physical activity, and persistent fatigue.
Some patients with a severe gastric ulcers may also experience symptoms of vomiting blood, feeling faint or losing consciousness. However, 75% of patients with gastric ulcers do not feel any symptoms.
If you have some of the above symptoms, please make that you check with your doctor to rule out the possibility of the condition.
Treatment of gastric ulcer is totally depending on the causes, such as histamine receptor blockers (H2 blockers) or proton pump inhibitors (PPIs) for patients with gastric ulcers induced by overproduction of stomach acid and the antibiotics for the infection caused by H. pylori.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan.
The herb has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc.
It is also one of many popular herbs studied in scientific ways with some conflicting results.
The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols. All ingredients work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.
In the study to examine the effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels, and gastric ulcer healing in 48 Male Spraque-Dawley rat divided into four groups as the following, group1 served a as control group, group 2 as gastric ulcer group without treatment, groups 3 and 4 as gastric ulcer treatment groups with sucralfate and Aloe vera, researchers found
* On day 1 after induction of gastric ulcer and before treatment the leukocyte adherence in postcapillary venule was significantly increased in the ulcer groups, an indication of the immune response to the gastric damage when compared to the control group. The level of TNF-alpha was elevated and the level of IL-10 was reduced, an indication of overexpression of pro-inflammatory cytokines.
* In the ulcer groups treated with sucralfate and Aloe vera, leukocyte adherence was reduced in postcapillary venule. The level of IL-10 was elevated, but the level of TNF-. alpha had no significant difference, an indication of the leading process with the presence of anti-inflammatory cytokine.
* On day 8, the leukocyte adherence in postcapillary venule and the level of TNF-alpha were still increased and the level of IL-10 was reduced in the ulcer group without treatment.
Dr. Eamlamnam K, the lead scientist at the final days of the study, wrote, "histopathological examination of the stomach on days 1 and 8 after induction of gastric ulcer showed that gastric tissue was damaged with inflammation. In the ulcer groups treated with sucralfate and Aloe vera on days 1 and 8, gastric inflammation was reduced, epithelial cell proliferation was enhanced and gastric glands became elongated".
The results further confirm the efficacy of Aloe vera in promoting gastric ulcer healing, through the expressions of leukocyte adherence and TNF-alpha level, elevate IL-10 level.
Additionally, in the examination of the anti-inflammatory effects of Aloe vera on leukocyte-endothelium in the gastric microcirculation of Helicobacter pylori (H. pylori)-infected of 36 male Sprague-Dawley rats divided into 3 groups: control, H. pylori-infected, and A. vera-treated group (200 mg/kg b.w., twice daily). researchers found that
* H. pylori-infected group shows a significant increase of the leukocyte adhesion cells and the TNF-alpha level compared with the control group on day 8.
* After treatment with A. vera H. pylori-infected group exerts a reduced leukocyte adhesion and TNF-alpha significantly.
Dr. Prabjone R, the lead author at the final conclusion said, "enhancement in leukocyte-endothelium interaction could be improved by the treatment of A. vera, associated with the reduction in TNF-alpha level".
Interestingly, in the acute gastric mucosal lesions induced by 0.6 M HCl and acid output Aloe vera endowed with gastric acid anti-secretory activity were found to protect the gastric mucosa at low concentrations against injurious agents. Its bioactive component, the Polymer fraction reduces 50% of the mRNA expressions of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS) in the initiation of the pathogenesis of inflammation.
Taken altogether, herbal Aloe vera may be considered a functional food for the prevention and treatment of gastric ulcer without inducing any side effects.
However, due to the limitation of the above studies, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of herbal Aloe vera anti-gastric ulcers possibilities.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(2) Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats, by Eamlamnam K, Patumraj S, Visedopas N, Thong-Ngam D.(PubMed)
(3) The effect of Aloe vera A. Berger (Liliaceae) on gastric acid secretion and acute gastric mucosal injury in rats by Yusuf S, Agunu A, Diana M.(PubMed)(4) Anti-inflammatory effects of Aloe vera on leukocyte-endothelium interaction in the gastric microcirculation of Helicobacter pylori-infected rats by Prabjone R, Thong-Ngam D, Wisedopas N, Chatsuwan T, Patumraj S.(PubMed)
(5) Polymer fraction of Aloe vera exhibits a protective activity on ethanol-induced gastric lesions.
Park CH, Nam DY, Son HU, Lee SR, Lee HJ, Heo JC, Cha TY, Baek JH, Lee SH.(PubMed)
Herbal Andrographis and Rheumatoid Arthritis
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chickenpox, etc.
Rheumatoid Arthritis has defined as a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than in men and generally occurs after the ages of 40 and diminishes the quality of life of many elders.
The Ingredients
Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.
The benefits
Andrographis paniculata (AP) possesses anti-inflammatory effects, as a result of its main constituent andrographolide proposed as alternative in the treatment of autoimmune disease, according to the study of Tablets (Paractin) made of an extract of A. paniculata (30% total andrographolides) were administered three times a day for 14 weeks, after a 2-week washout period to 60 patients with active RA. In the study of osteoclast formation, AP suppressed RANKL-induced osteoclastogenesis through attenuating NF-κB and ERK/MAPK signaling pathways in vitro, thus preventing bone loss in vivo. of which may be a potential therapeutic natural compound for the treatment of osteoclast-related bone diseases. Others in the study of the pseudo-tumoral expansion of fibroblast-like synoviocytes which is a hallmark of rheumatoid arthritis (RA), showed that andrographolide exerts anti-growth and pro-apoptotic effects on RAFLSs, thus may have therapeutic potential for the treatment of RA. by induced cell cycle arrest and apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.
The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.
3. Etc.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Women health http://kylejnorton.blogspot.ca/p/women-health.html
References
1. Andrographis paniculata, http://essenherb.com/plant1.html
2. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial, by Burgos RA, Hancke JL, Bertoglio JC, Aguirre V, Arriagada S, Calvo M, Cáceres DD. (PubMed)
3. Andrographolide induces cell cycle arrest and apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes. by Yan J, Chen Y, He C, Yang ZZ, Lü C, Chen XS.(PubMed)
4. Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
Rheumatoid Arthritis has defined as a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than in men and generally occurs after the ages of 40 and diminishes the quality of life of many elders.
The Ingredients
Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.
The benefits
Andrographis paniculata (AP) possesses anti-inflammatory effects, as a result of its main constituent andrographolide proposed as alternative in the treatment of autoimmune disease, according to the study of Tablets (Paractin) made of an extract of A. paniculata (30% total andrographolides) were administered three times a day for 14 weeks, after a 2-week washout period to 60 patients with active RA. In the study of osteoclast formation, AP suppressed RANKL-induced osteoclastogenesis through attenuating NF-κB and ERK/MAPK signaling pathways in vitro, thus preventing bone loss in vivo. of which may be a potential therapeutic natural compound for the treatment of osteoclast-related bone diseases. Others in the study of the pseudo-tumoral expansion of fibroblast-like synoviocytes which is a hallmark of rheumatoid arthritis (RA), showed that andrographolide exerts anti-growth and pro-apoptotic effects on RAFLSs, thus may have therapeutic potential for the treatment of RA. by induced cell cycle arrest and apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.
The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.
3. Etc.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Women health http://kylejnorton.blogspot.ca/p/women-health.html
References
1. Andrographis paniculata, http://essenherb.com/plant1.html
2. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial, by Burgos RA, Hancke JL, Bertoglio JC, Aguirre V, Arriagada S, Calvo M, Cáceres DD. (PubMed)
3. Andrographolide induces cell cycle arrest and apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes. by Yan J, Chen Y, He C, Yang ZZ, Lü C, Chen XS.(PubMed)
4. Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
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