Herbal Alfalfa may process an estrogenic effect for the treatment of estrogen-deficient diseases and symptoms, some studies found.
The estrogenic effect is an action that stimulates the production of the hormone estrogen in case of deficiency.
Menopause symptoms are a set of symptoms caused by the gradual decline of levels of estrogen and progesterone due to aging loss menstrual period in women.
The reproductive tract, the urinary tract, the heart and blood vessels, bones, breasts, skin, hair, mucous membranes, pelvic muscles normally regulated by hormone estrogen also are affected by the decline levels of the hormone.
In the concern of hormone therapy used for the treatment of menopause symptoms, herbal medicine with estrogenic effect have been under intensive investigation, with an aim to find a natural ingredient with the similar effects as of those used in hormone therapy with no side effects.
Dr. the lead scientist at the Pan-American Health Organization/World Health Organization Collaborating Centre for Traditional Medicine launched an evaluation to examine the estrogenic activity of seventeen plant species collected and extracted in Costa Rica.
Interestingly, only 6 of the plant extracts bound to the ERs with 4 of the six extracts stimulated reporter gene expression, according to the ER-beta-Chemically Activated Luciferase Expression assay.
Four extracts exerted estrogenic activity also act as estrogen agonists.
In other words, these extracts induced the production of estrogen when the body needs and inhibited levels of estrogen when the hormone is overexpressed in the body.
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae.
The herbal plant has been cultivated all over the world as hay for cattle feeding.
The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance the digestive system, bleeding disorder, kidney, and urinary tract infection, etc.
North America aboriginal has used Alfalfa seed as food, such as making bread and mush.
The chemical constituents of alfalfa include flavones, isoflavones, sterols, Bichanin A, Coumestrol Diadzein, Formonetin, Genistein, and coumarin derivatives, etc.
A study to determine whether estrogenic botanical supplement (EBS) use influences breast cancer survivors' health-related outcomes.was conducted by the research team at the Beckman Research Institute.
The study includes 767 breast cancer survivors who filled out the returned questionnaire suggested that EBS improve quality of life by reducing some of the symptom associated with 15 hormone-related symptoms such as hot flashes and night sweats.
However, Dr. Ma H, the lead author after taking into account co and confounders said, "Our findings indicate that several specific types of EBS might have important influences on a woman's various aspects of quality of life".
Additionally, in the study to clarify the effect of phytoestrogens is a group of lipophilic plant compounds, researchers launched an investigation to examine examined the proliferative effects of phytoestrogens on a rat pituitary tumor cell line, GH3/B6/F10, originally subcloned from GH3 cells based on its ability to express high levels of the membrane estrogen receptor-alpha.
The phytoestrogen compounds included in the study at the range of different concentrations are coumestrol, daidzein, genistein, and trans-resveratrol.
All four phytoestrogens attenuated the proliferative effects of estradiol when administered simultaneously.
Except for trans-resveratrol, all phytoestrogens increased GH3/B6/F10 cell proliferation at some concentration relevant to dietary levels.
All phytoestrogens exerted significant anti-proliferative activity, but with time course patterns that often differed from that of estradiol and each other.
More importantly, except for trans-resveratrol, a serum removal-induced extrinsic apoptotic pathway was blocked by these phytoestrogens.
These results clearly suggested, injection of single ingredients of phytochemicals may both tumorigenic and anti-tumorigenic effects and intake of the estrogenic whole food which processed all the ingredient exerted a strong anti-tumorigenic activity.
Taken all together, there is no doubt that herbal Alfalfa processed a strong estrogenic effect may be considered a functional food for the treatment of diseases and symptoms associated with estrogen deficiency.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Drug-induced lupus: an update by Vasoo S.(PubMed)
(2) Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL study report by Ma H, Sullivan-Halley J, Smith AW, Neuhouser ML, Alfano CM, Meeske K, George SM, McTiernan A, McKean-Cowdin R, Baumgartner KB, Ballard-Barbash R, Bernstein L.(PubMed)
(3) Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10 cells - the involvement of rapidly activated kinases and caspases by Jeng YJ, Watson CS.(PubMed)
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