Scientists may have found a herbal plant for the treatment of inflammatory diseases with no side effects, according to the studies.
Inflammation is a natural reaction of the immune system's self-protection to remove harmful stimuli, including damaged cells, irritants, pathogens... from our body.
Acute inflammatory inflammation is a result of the over-response of the immune system after sensing the injury or damage of the body through activating the protein associated with the production of pro-inflammatory cytokines.
The aim of the proinflammatory cytokines is to kill the invasive pathogens, which try to enter the body through the wound.
The immune system in the stimulating production of proinflammatory cytokines may induce overproduction of these cytokines can cause death or damage to the nearby cells, leading to scar formation and symptoms of localized swelling, redness and fever.
Chronic inflammation is a serious condition caused by the immune system to adapt to the new change due to its inability to kill all the invasion within a set of times.
Some researchers in the observation of the history of immune evolution suggested that immune system also try to adapt to the new environment such as chronic inflammation if, for whatever reasons, it can not fill all invasive pathogens within 3 to weeks, leading to the development of several diseases and conditions, including some cancers and rheumatoid arthritis.
Furthermore, chronic inflammation can also be caused by the autoimmune disorder, which involves your immune system mistakenly attacking healthy tissue, long-term exposure to irritants, such as industrial chemicals or polluted air.
Dr. Anne M. Minihane, the lead scientist in the study "Low-grade inflammation, diet composition, and health: current research evidence and its translation" wrote, "An unresolved inflammatory response is likely to be involved from the early stages of disease development" and " The latest research in the areas of acute and chronic inflammation and cardiometabolic, gut and cognitive health is presented along with the cellular and molecular mechanisms underlying inflammation–health/disease associations".
And. " Such approaches are likely to provide a more discriminating means of quantifying inflammation–health/disease associations, and the ability of diet to positively modulate inflammation and provide the much-needed evidence to develop research portfolios that will inform new product development and associated health claims".
The results clearly suggested that adding certain amounts of anti-inflammatory foods into your diet may be the best way to prevent chronic inflammatory diseases.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chickenpox, etc.
Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.
With an aim to reaffirm the traditional use of Andrographis paniculata for treatment of infection and inflammation, researchers examined the effects of Andrograpanin, one of the diterpene lactones in A. paniculata in vivo and in vitro.
Application of Andrograpanin inhibited the NO and other 3 pro-inflammatory cytokines in a range from 5-90 microM in a dose-dependent manner.
The efficacy of anti-inflammatory activity of Andrograpanin was associated with the reduction of the expression of iNOS, enzymes in catalyzing the production of NO and pro-inflammatory cytokines gene (proteins) expression.
Furthermore, the anti-inflammatory effects were contributed by inhibiting the protein (p38) and (mitogen-activated protein kinase (MAPKs)) which are responsive to stress stimuli, p38 and stress response.
Dr. Liu J, after taking into account co and confounders wrote, "andrograpanin might be useful as a potential anti-inflammatory leading compound for inflammatory drug development".
Additional analysis of other major compound isolated from herbal Andrographis, researchers looked into Human β-defensin-2 (hBD-2), an inducible antimicrobial peptide that plays an important role in innate immunity.
As a prediction, according to the PCR and Western blot assays, injection of Andro (1.0-10 µmol/L) exhibits the expression of hBD-2 in a dose-dependent manner.
However, under the expression of SB203580 (an inhibitor of p38 mitogen-activated protein kinase (p38 MAPK)), MG-132 (an inhibitor of nuclear factor κB (NF-κB)), and an NF-κB activator inhibitor, but not by an inhibitor of ERK (PD98059) or by an inhibitor of JNK(SP600125), the effects of hBD-2 mRNA and protein expression in responsive to andro were attenuated.
These results clearly suggested andro exert its antimicrobial effects by exhibiting the expression of hBD-2 through regulating the functions of the innate immune response against stress and stimuli.
Taken altogether, herbal Andrographis processed high levels of bioactive compounds may be considered a functional remedy against inflammation and infection.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(2) Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells BY He CL, Yi PF, Fan QJ, Shen HQ, Jiang XL, Qin QQ, Song Z, Zhang C, Wu SC, Wei XB, Li YL, Fu BD. (PubMed)
(3) Andrographolide exerted its antimicrobial effects by upregulation of human β-defensin-2 induced through p38 MAPK and NF-κB pathway in human lung epithelial cells by Shao ZJ, Zheng XW, Feng T, Huang J, Chen J, Wu YY, Zhou LM, Tu WW, Li H.(PubMed).
(4) Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory property in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways by Liu J, Wang ZT, Ge BX.(PubMed)
(5) Low-grade inflammation, diet composition and health: current research evidence and its translation by Anne M. Minihane, 1 ,* Sophie Vinoy, 2 Wendy R. Russell, 3 Athanasia Baka, 4 Helen M. Roche,5 Kieran M. Tuohy, 6 Jessica L. Teeling, 7 Ellen E. Blaak, 8 Michael Fenech, 9 David Vauzour, 1Harry J. McArdle, 3 Bas H. A. Kremer, 10 Luc Sterkman, 11 Katerina Vafeiadou, 12Massimo Massi Benedetti, 13 Christine M. Williams, 14 and Philip C. Calder. (PMC)
Friday, November 8, 2019
Artichoke, the Anti Hypercholesterolemia Herbal Remedy with No Side Effects, Scientists Find
Scientists may have found a herbal remedy for the treatment of hypercholesterolemia with no side effects, according to studies.
Cholesterol, a waxy substance produced by the liver plays a critical role in making hormones, vitamin D, building a strong cell membrane and digestive fluids. However, overexpression of cholesterol has been found to induce high blood pressure and heart diseases.
Not all cholesterols are bad, high-density lipoprotein, the type of cholesterol which returns the cholesterol back to the liver are constantly keeping the bad cholesterol (low-density lipoprotein) in check.
The healthy ratio of total cholesterol is 4 (LDL)/1 (HDL) or lower.
Hypercholesterolemia is a medical condition of abnormally high cholesterol levels in the blood compared to hyperlipidemia which is considered a syndrome of abnormally elevated levels of any or all lipids or lipoproteins in the blood.
People with high blood cholesterol do not experience any symptom. However, the condition has been found to associate with the increased risk of heart diseases and stroke. particularly, atherosclerosis.
Where atherosclerosis is a disease involved the accumulation of plaque on the arterial wall, leading to arterial blockage in facilitating cardiovascular diseases, depending on the location of the blockage.
Although there are many risk factors associated with the onset of high blood cholesterol, some researchers an unhealthy diet is one of the major risk factors that cause hypercholesterolemia in North America.
Dr. Joan Carles Escola`-Gil, the lead scientist in the evaluation of the Western diet risk of hypercholesterolemia in mice wrote, ". Unlike a low-fat, low-cholesterol diet, the A high–saturated fatty acid– and cholesterol-containing (HFHC) diet increased liver ABCG5/G8 expression. The effect of the HFHC diet on fecal macrophage-derived [3 H]cholesterol excretion was totally blunted in ABCG5/G8-deficient mice".
The results strongly suggested that if you follow the diet rich in high–saturated fatty acid–and cholesterol, your risk of hypercholesterolemia is increased many folds, compared to healthy adults with a traditional diet.
According to medical analysis, hypercholesterolemia is a form of hyperlipidemia, high blood lipids, and hyperlipoproteinemia.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Scientists on finding a natural ingredient for the treatment of hypercholesterolemia, compared the effects of well-established antiatherosclerotic drug atorvastatin (CAS number 134523-00-5) and commercially available artichoke leaf tincture (ALTINC) in an animal model.
The selected animal in the study was divided into five groups:
* The group I (the control group of rats fed with standard diet during 11 weeks), and the remaining 4 groups of rats (II, III, IV, and V) fed with standard diet during the first week and then with hypercholesterolemic diet during the next 10 weeks.
*The group II of rats were left without treatment, while in the groups III, IV, and V were rats treated per os with atorvastatin (1.15 mg/kg body weight--b.w.), ALTINC (0.1 mL/kg b.w.) and their combination in same doses, respectively, for the last six weeks.
During the experiment, Group IV treated ALTINC exerted a significant effect against the abdominal aorta wall thickness and parameters of oxidative stress induced by a high-fat diet, observed by the oxidative stress markers.
Rat treated with ALTINC also enhanced the production of antioxidant enzymes by the host that was suppressed by the high-fat diet feeding in the inhibition of lipid peroxidation, the condition was found to be associated with patients with hypercholesterolemia.
The results suggested the artichoke leaf tincture is a very potent antioxidant with beneficial effects in the early stages of atherosclerosis by reducing the overexpression cholesterol associated with plaque accumulated on the arterial wall.
In order to know more information about artichoke antihypercholesterolaemic effects, researchers examined the artichoke leaf extract (ALE) in lowering the levels of blood cholesterol.
By searching the databases of the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library) (2012, Issue 5); MEDLINE Ovid (1966 to May Week 2, 2012); EMBASE Ovid (1980 to 2012 Week 19); and CINAHL Ebsco (1982 to May 2012) on 17 May 2012, researchers selected 3 randomised controlled trials (RCTs) for the review./
In the first trial, the total cholesterol level in participants receiving ALE decreased by 4.2% from 7.16 (0.62) mmol/L to 6.86 (0.68) mmol/L after 12 weeks, compared to the increase from 6.90 (0.49) mmol/L to 7.04 (0.61) mmol/L in patients receiving placebo.
In the second trial, ALE reduced total cholesterol levels by 18.5% from 7.74 mmol/L to 6.31 mmol/L after 42 ± 3 days of treatment, whereas placebo reduced cholesterol by 8.6% from 7.69 mmol/L to 7.03 mmol/L.
The third trial stated that ALE significantly reduced blood cholesterol compared with placebo in a subgroup of patients with baseline total cholesterol levels of more than 230 mg/dL.
The review strongly suggested artichoke may process the potential for the treatment of hypercholesterolemia with no side effects.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of high blood cholesterol, pending to the reconfirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
hypercholesterolemia
(1) Effects of atorvastatin and artichoke leaf tincture on oxidative stress in hypercholesterolemic rats by Crevar-Sakac M, Vujić Z, Kotur-Stevuljević J, Ivanisević J, Jelić-Ivanović Z, Milenković M, Markelić M, Vujcić Z. (PubMed)
(2) Artichoke leaf extract for treating hypercholesterolaemia by Wider B1, Pittler MH, Thompson-Coon J, Ernst E. (PubMed)
(3) The Cholesterol Content of Western Diets Plays a Major Role in the Paradoxical Increase in High-Density Lipoprotein Cholesterol and Upregulates the Macrophage Reverse Cholesterol Transport Pathway by Joan Carles Escola`-Gil, Gemma Llaverias, Josep Julve, Matti Jauhiainen, Jesu´s Me´ndez-Gonza´lez, Francisco Blanco-Vaca
Cholesterol, a waxy substance produced by the liver plays a critical role in making hormones, vitamin D, building a strong cell membrane and digestive fluids. However, overexpression of cholesterol has been found to induce high blood pressure and heart diseases.
Not all cholesterols are bad, high-density lipoprotein, the type of cholesterol which returns the cholesterol back to the liver are constantly keeping the bad cholesterol (low-density lipoprotein) in check.
The healthy ratio of total cholesterol is 4 (LDL)/1 (HDL) or lower.
Hypercholesterolemia is a medical condition of abnormally high cholesterol levels in the blood compared to hyperlipidemia which is considered a syndrome of abnormally elevated levels of any or all lipids or lipoproteins in the blood.
People with high blood cholesterol do not experience any symptom. However, the condition has been found to associate with the increased risk of heart diseases and stroke. particularly, atherosclerosis.
Where atherosclerosis is a disease involved the accumulation of plaque on the arterial wall, leading to arterial blockage in facilitating cardiovascular diseases, depending on the location of the blockage.
Although there are many risk factors associated with the onset of high blood cholesterol, some researchers an unhealthy diet is one of the major risk factors that cause hypercholesterolemia in North America.
Dr. Joan Carles Escola`-Gil, the lead scientist in the evaluation of the Western diet risk of hypercholesterolemia in mice wrote, ". Unlike a low-fat, low-cholesterol diet, the A high–saturated fatty acid– and cholesterol-containing (HFHC) diet increased liver ABCG5/G8 expression. The effect of the HFHC diet on fecal macrophage-derived [3 H]cholesterol excretion was totally blunted in ABCG5/G8-deficient mice".
The results strongly suggested that if you follow the diet rich in high–saturated fatty acid–and cholesterol, your risk of hypercholesterolemia is increased many folds, compared to healthy adults with a traditional diet.
According to medical analysis, hypercholesterolemia is a form of hyperlipidemia, high blood lipids, and hyperlipoproteinemia.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Scientists on finding a natural ingredient for the treatment of hypercholesterolemia, compared the effects of well-established antiatherosclerotic drug atorvastatin (CAS number 134523-00-5) and commercially available artichoke leaf tincture (ALTINC) in an animal model.
The selected animal in the study was divided into five groups:
* The group I (the control group of rats fed with standard diet during 11 weeks), and the remaining 4 groups of rats (II, III, IV, and V) fed with standard diet during the first week and then with hypercholesterolemic diet during the next 10 weeks.
*The group II of rats were left without treatment, while in the groups III, IV, and V were rats treated per os with atorvastatin (1.15 mg/kg body weight--b.w.), ALTINC (0.1 mL/kg b.w.) and their combination in same doses, respectively, for the last six weeks.
During the experiment, Group IV treated ALTINC exerted a significant effect against the abdominal aorta wall thickness and parameters of oxidative stress induced by a high-fat diet, observed by the oxidative stress markers.
Rat treated with ALTINC also enhanced the production of antioxidant enzymes by the host that was suppressed by the high-fat diet feeding in the inhibition of lipid peroxidation, the condition was found to be associated with patients with hypercholesterolemia.
The results suggested the artichoke leaf tincture is a very potent antioxidant with beneficial effects in the early stages of atherosclerosis by reducing the overexpression cholesterol associated with plaque accumulated on the arterial wall.
In order to know more information about artichoke antihypercholesterolaemic effects, researchers examined the artichoke leaf extract (ALE) in lowering the levels of blood cholesterol.
By searching the databases of the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library) (2012, Issue 5); MEDLINE Ovid (1966 to May Week 2, 2012); EMBASE Ovid (1980 to 2012 Week 19); and CINAHL Ebsco (1982 to May 2012) on 17 May 2012, researchers selected 3 randomised controlled trials (RCTs) for the review./
In the first trial, the total cholesterol level in participants receiving ALE decreased by 4.2% from 7.16 (0.62) mmol/L to 6.86 (0.68) mmol/L after 12 weeks, compared to the increase from 6.90 (0.49) mmol/L to 7.04 (0.61) mmol/L in patients receiving placebo.
In the second trial, ALE reduced total cholesterol levels by 18.5% from 7.74 mmol/L to 6.31 mmol/L after 42 ± 3 days of treatment, whereas placebo reduced cholesterol by 8.6% from 7.69 mmol/L to 7.03 mmol/L.
The third trial stated that ALE significantly reduced blood cholesterol compared with placebo in a subgroup of patients with baseline total cholesterol levels of more than 230 mg/dL.
The review strongly suggested artichoke may process the potential for the treatment of hypercholesterolemia with no side effects.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of high blood cholesterol, pending to the reconfirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
hypercholesterolemia
(1) Effects of atorvastatin and artichoke leaf tincture on oxidative stress in hypercholesterolemic rats by Crevar-Sakac M, Vujić Z, Kotur-Stevuljević J, Ivanisević J, Jelić-Ivanović Z, Milenković M, Markelić M, Vujcić Z. (PubMed)
(2) Artichoke leaf extract for treating hypercholesterolaemia by Wider B1, Pittler MH, Thompson-Coon J, Ernst E. (PubMed)
(3) The Cholesterol Content of Western Diets Plays a Major Role in the Paradoxical Increase in High-Density Lipoprotein Cholesterol and Upregulates the Macrophage Reverse Cholesterol Transport Pathway by Joan Carles Escola`-Gil, Gemma Llaverias, Josep Julve, Matti Jauhiainen, Jesu´s Me´ndez-Gonza´lez, Francisco Blanco-Vaca
Thursday, November 7, 2019
Broccoli Sprout Protects Diabetics Against Diabetic Cardiomyopathy
Diabetes is a medical condition characterized by the failure of the body to utilize the insulin in converting glucose to energy, leading to high levels of glucose in the bloodstream.
Most cases of diabetes are associated with either beta cells of the pancreas died-off or insulin receptor site clogged-up by fat and cholesterol.
Diabetic complications in most cases are caused by long-term unmanaged hyperglycemia, a hallmark of diabetes.
Most common complication of diabetes is associated with the damage of tiny blood vessels that nourish the related organ and tissues, leading to the risk for developing microvascular and macrovascular complications. includes cardiovascular disease.
Diabetic cardiomyopathy is a complication of the heart muscle in people with diabetes, leading to heart failure that causes the reduced function of the heart to circulate blood through the body.
Most common symptoms of diabetic cardiomyopathy are the accumulation of fluid in the lungs or legs.
Dr. Adeghate E, in the examination of the diabetic cardiomyopathy associated with the structural changes in the myocardium of diabetes, wrote, " If left unmanaged, DM can lead to numerous long-term complications including micro- and macro-angiopathy and heart failure (HF)".
And, "Most diabetics usually die as a result of HF resulting from diabetes-induced coronary artery disease and cardiomyopathy. Coronary artery disease and cardiomyopathy are normally preceded by hyperglycemia (HG)".
In other words, management diabetes by preventing the onset of hyperglycemia is the most effective way to reduce the risk of diabetic cardiomyopathy in diabetes.
More precisely, by following a healthy diet to normalize the levels of HbA1c level, accompanied by moderate exercise, the risk of diabetic complications can be manageable.
Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. It has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
With an aim to find a natural food for the prevention and treatment of diabetic cardiomyopathy, researchers examined the effect of broccoli sprout extract in an animal model.
The study included male db/db and age-matched wild-type (WT) mice given sulforaphane (SFN, an Nrf2 activator) and its natural source, broccoli sprout extract (BSE) by gavage every other day for 3 months, including vehicle (0.1 ml/10 g), BSE-low dose (estimated SFN availability at 0.5 mg/kg), BSE-high dose (estimated SFN availability at 1.0 mg/kg), and SFN (0.5 mg/kg).
According to the results of echocardiography and histopathological analysis, both BSE and SFN showed significant prevention of diabetes-induced cardiac dysfunction, hypertrophy, and fibrosis.
Furthermore, BSE, like SFN, significantly exhibited the Nrf2 transcriptional activity associated with protective effect oxidative damage triggered by injury and inflammation.
In other words, stimulating the Nrf2 function of the protein, BSE, and SFN significantly prevented cardiac oxidative damage and inflammation.
Moreover, BSE at high doses exerted the similar effect as those of SFN. particularly, in BSE at a high dose that works synergistically with SFN to prevent DCM.
Based on the findings, researchers said, "BSE could potentially be used as a natural and safe treatment against DCM via Nrf2 activation".
Taken altogether, broccoli sprout processed abundantly SFN may be considered supplements for the prevention and treatment of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice by Xu Z, Wang S, Ji H, Zhang Z, Chen J, Tan Y, Wintergerst K, Zheng Y, Sun J, Cai L. (PubMed)
(2) Structural changes in the myocardium during diabetes-induced cardiomyopathy by Adeghate E1, Singh J. (PubMed)
Most cases of diabetes are associated with either beta cells of the pancreas died-off or insulin receptor site clogged-up by fat and cholesterol.
Diabetic complications in most cases are caused by long-term unmanaged hyperglycemia, a hallmark of diabetes.
Most common complication of diabetes is associated with the damage of tiny blood vessels that nourish the related organ and tissues, leading to the risk for developing microvascular and macrovascular complications. includes cardiovascular disease.
Diabetic cardiomyopathy is a complication of the heart muscle in people with diabetes, leading to heart failure that causes the reduced function of the heart to circulate blood through the body.
Most common symptoms of diabetic cardiomyopathy are the accumulation of fluid in the lungs or legs.
Dr. Adeghate E, in the examination of the diabetic cardiomyopathy associated with the structural changes in the myocardium of diabetes, wrote, " If left unmanaged, DM can lead to numerous long-term complications including micro- and macro-angiopathy and heart failure (HF)".
And, "Most diabetics usually die as a result of HF resulting from diabetes-induced coronary artery disease and cardiomyopathy. Coronary artery disease and cardiomyopathy are normally preceded by hyperglycemia (HG)".
In other words, management diabetes by preventing the onset of hyperglycemia is the most effective way to reduce the risk of diabetic cardiomyopathy in diabetes.
More precisely, by following a healthy diet to normalize the levels of HbA1c level, accompanied by moderate exercise, the risk of diabetic complications can be manageable.
Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. It has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
With an aim to find a natural food for the prevention and treatment of diabetic cardiomyopathy, researchers examined the effect of broccoli sprout extract in an animal model.
The study included male db/db and age-matched wild-type (WT) mice given sulforaphane (SFN, an Nrf2 activator) and its natural source, broccoli sprout extract (BSE) by gavage every other day for 3 months, including vehicle (0.1 ml/10 g), BSE-low dose (estimated SFN availability at 0.5 mg/kg), BSE-high dose (estimated SFN availability at 1.0 mg/kg), and SFN (0.5 mg/kg).
According to the results of echocardiography and histopathological analysis, both BSE and SFN showed significant prevention of diabetes-induced cardiac dysfunction, hypertrophy, and fibrosis.
Furthermore, BSE, like SFN, significantly exhibited the Nrf2 transcriptional activity associated with protective effect oxidative damage triggered by injury and inflammation.
In other words, stimulating the Nrf2 function of the protein, BSE, and SFN significantly prevented cardiac oxidative damage and inflammation.
Moreover, BSE at high doses exerted the similar effect as those of SFN. particularly, in BSE at a high dose that works synergistically with SFN to prevent DCM.
Based on the findings, researchers said, "BSE could potentially be used as a natural and safe treatment against DCM via Nrf2 activation".
Taken altogether, broccoli sprout processed abundantly SFN may be considered supplements for the prevention and treatment of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice by Xu Z, Wang S, Ji H, Zhang Z, Chen J, Tan Y, Wintergerst K, Zheng Y, Sun J, Cai L. (PubMed)
(2) Structural changes in the myocardium during diabetes-induced cardiomyopathy by Adeghate E1, Singh J. (PubMed)
Herbal Arctostaphylos uva-ursi, the Anti Diabetes Functional Remedy
Scientists may have found a medicinal plant for the treatment of diabetes with no side effects, according to the studies.
Diabetes is a medical and chronic condition characterized by insufficient insulin entering the bloodstream to regulate the glucose.
In other words, diabetes is a result of abnormally and chronically high levels of sugar (glucose) in the blood. Insulin resistance is a hallmark of diabetes. The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol.
Insulin receptors are areas on the outer part of a cell that allow the cell to bind with insulin in the blood. When the receptors are clogged up, the cell can not take glucose (sugar) from the blood and use it for energy.
Researchers do not know what causes insulin resistance in diabetic patients. However, researchers do know that long-term intake of a poor diet with high saturated and trans fat, red meat and processed food is one of many risk factors associated with clogged up the insulin receptors sites, leading to high blood glucose.
Dr. David Hefner in the concern of the Western diet linked to type 2 diabetes, wrote, "The researchers surveyed 42,000 men over a 12-year period. The men's eating habits were divided into two groups: those who followed a Western diet and those who followed a "prudent" diet with fruit, vegetables, whole grain, fish and poultry. "Over the course of the study ... 1,321 new cases of Type 2 diabetes were diagnosed".
These results clearly suggested that by changing to a healthy diet pattern with high fruits and vegetables and reducing the intake of saturated and trans fat, red meat and processed food, diabetes is preventable.
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and for the treatment of urinary problems, including bladder infections, kidney infection, kidney stones, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
On finding a natural formula for the treatment of diabetic symptoms that leads to the investigated 7 plants and a herbal mixture used for the traditional treatment of diabetes in streptozotocin-diabetic mice conducted by the University of Ulster.
In streptozotocin-diabetic mice, the formula was supplied as 6.25% by weight of the diet for 9 days.
The consumption of diets containing bearberry (Arctostaphylos uva-ursi), significantly reduced the excessive hunger and abnormally large intake of solids and excessive thirst or excess water drinking associated with streptozotocin diabetes.
However, other herbal plants in the herbal formula such as bayberry (Cinnamomum tamala), meadowsweet (Filipendula ulmaria), Senna (Cassia occidentalis) and the herbal mixture did not alter these parameters.
Bearberry, mistletoe, and tarragon retarded body weight loss, reduced symptoms of diabetes without significantly altered plasma glucose or insulin concentrations.
The results suggested that only bearberry, goldenseal, mistletoe, and tarragon can counter some of the symptoms of streptozotocin diabetes without affecting glycemic control.
Taken altogether, bearberry (Herbal Arctostaphylos uva-ursi) may be used as a functional remedy for the treatment of some diabetic symptoms, pending to the confirmation of large sample size and multicenter in a human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice by Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR.(PubMed)
(2) Western Diet Linked to Type 2 Diabetes by David Hefner. (PMC)
Diabetes is a medical and chronic condition characterized by insufficient insulin entering the bloodstream to regulate the glucose.
In other words, diabetes is a result of abnormally and chronically high levels of sugar (glucose) in the blood. Insulin resistance is a hallmark of diabetes. The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol.
Insulin receptors are areas on the outer part of a cell that allow the cell to bind with insulin in the blood. When the receptors are clogged up, the cell can not take glucose (sugar) from the blood and use it for energy.
Researchers do not know what causes insulin resistance in diabetic patients. However, researchers do know that long-term intake of a poor diet with high saturated and trans fat, red meat and processed food is one of many risk factors associated with clogged up the insulin receptors sites, leading to high blood glucose.
Dr. David Hefner in the concern of the Western diet linked to type 2 diabetes, wrote, "The researchers surveyed 42,000 men over a 12-year period. The men's eating habits were divided into two groups: those who followed a Western diet and those who followed a "prudent" diet with fruit, vegetables, whole grain, fish and poultry. "Over the course of the study ... 1,321 new cases of Type 2 diabetes were diagnosed".
These results clearly suggested that by changing to a healthy diet pattern with high fruits and vegetables and reducing the intake of saturated and trans fat, red meat and processed food, diabetes is preventable.
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and for the treatment of urinary problems, including bladder infections, kidney infection, kidney stones, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
On finding a natural formula for the treatment of diabetic symptoms that leads to the investigated 7 plants and a herbal mixture used for the traditional treatment of diabetes in streptozotocin-diabetic mice conducted by the University of Ulster.
In streptozotocin-diabetic mice, the formula was supplied as 6.25% by weight of the diet for 9 days.
The consumption of diets containing bearberry (Arctostaphylos uva-ursi), significantly reduced the excessive hunger and abnormally large intake of solids and excessive thirst or excess water drinking associated with streptozotocin diabetes.
However, other herbal plants in the herbal formula such as bayberry (Cinnamomum tamala), meadowsweet (Filipendula ulmaria), Senna (Cassia occidentalis) and the herbal mixture did not alter these parameters.
Bearberry, mistletoe, and tarragon retarded body weight loss, reduced symptoms of diabetes without significantly altered plasma glucose or insulin concentrations.
The results suggested that only bearberry, goldenseal, mistletoe, and tarragon can counter some of the symptoms of streptozotocin diabetes without affecting glycemic control.
Taken altogether, bearberry (Herbal Arctostaphylos uva-ursi) may be used as a functional remedy for the treatment of some diabetic symptoms, pending to the confirmation of large sample size and multicenter in a human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice by Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR.(PubMed)
(2) Western Diet Linked to Type 2 Diabetes by David Hefner. (PMC)
Herbal Turmeric Improves the Inflammatory Response Against Renal Toxicity
The immunomodulatory effect is a process in which the immune function is modulated to the needs of the body.
The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.
The immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system.
* The overactive immune system is also known as autoimmune diseases.
In the acute phase of infection, the immune macrophages, the first line of defense stimulates the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.
Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.
Most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.
Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.
However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in the set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.
Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory disease, including diabetes, arthritis, and cardiovascular disease.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a natural ingredient for the modulation of the immune response, researchers examined the metformin and curcumin alone or in combination on nephrotoxicity induced by GM.
According to the tested differentiation,
* Both metformin and curcumin, when used alone, were effectively decreasing GM-induced nephrotoxicity.
* Both drug combination exerted a synergistic effect in ameliorating a GM-induced kidney injury, by expressively improved renal dysfunction.
* Moreover, in a GM treated animal model, metformin and curcumin showed strong protection against oxidative stress by decreasing the activities and expression of various oxidative enzymes.
* The combination also exerted a strong anti-inflammatory response by inhibiting the expression of pro-inflammatory cytokines in GM intoxicated group of animals.
Based on the findings, researchers said, " combinational treatment of metformin and curcumin might have a synergizing effect and substantial potential against nephrotoxicity".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for controlling the body's immune response, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combinational effect of curcumin and metformin against gentamicin-induced nephrotoxicity: Involvement of antioxidative, anti-inflammatory and antiapoptotic pathway by Cao L1, Zhi D1, Han J1, Kumar Sah S2, Xie Y. (PubMed)
The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.
The immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system.
* The overactive immune system is also known as autoimmune diseases.
In the acute phase of infection, the immune macrophages, the first line of defense stimulates the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.
Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.
Most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.
Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.
However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in the set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.
Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory disease, including diabetes, arthritis, and cardiovascular disease.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a natural ingredient for the modulation of the immune response, researchers examined the metformin and curcumin alone or in combination on nephrotoxicity induced by GM.
According to the tested differentiation,
* Both metformin and curcumin, when used alone, were effectively decreasing GM-induced nephrotoxicity.
* Both drug combination exerted a synergistic effect in ameliorating a GM-induced kidney injury, by expressively improved renal dysfunction.
* Moreover, in a GM treated animal model, metformin and curcumin showed strong protection against oxidative stress by decreasing the activities and expression of various oxidative enzymes.
* The combination also exerted a strong anti-inflammatory response by inhibiting the expression of pro-inflammatory cytokines in GM intoxicated group of animals.
Based on the findings, researchers said, " combinational treatment of metformin and curcumin might have a synergizing effect and substantial potential against nephrotoxicity".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for controlling the body's immune response, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combinational effect of curcumin and metformin against gentamicin-induced nephrotoxicity: Involvement of antioxidative, anti-inflammatory and antiapoptotic pathway by Cao L1, Zhi D1, Han J1, Kumar Sah S2, Xie Y. (PubMed)
Artichoke, Protects the Liver Cells Against Acute Alcohol-Induced Liver Injury, Studies Found
Artichoke may be used as a herbal remedy for the protection liver against acute alcohol-induced liver injury, according to studies.
Acute alcohol-induced liver injury is a condition caused excessive alcohol drinking in a short term.
Acute alcohol binges have been found to induce acute liver toxicity and contribute to the chronicity of alcoholic liver disease (ALD).
The condition has been found increasingly in people aged 18–25, probably, due to severe CNS depression, which slows motor coordination and respiratory rates.
Believe it or not, over 50% of Americans consume alcohol, 23.1% of them participating in heavy and/or binge drinking at least once a month, leading to acute alcoholic liver toxicity in the initiation and progression of alcoholic liver disease.
In fact, heavy and/or binge drinking has been associated with the onset of steatosis or fatty liver caused by alcohol metabolism in the induction of liver fat accumulation.
Dr. Veronica L. Massey, the lead scientists, in the explanation of how alcoholic metabolism induced fatty liver, said, "Concentrations of alcohol can easily reach the mM range in the portal/hepatic circulation during alcohol consumption. In the process of metabolizing ethanol to acetate, two equivalents of reduced NADH are generated per equivalent of ethanol oxidized" and, "This metabolism robustly increases the ratio of NADH:NAD+ within the cell, which then inhibits the β-oxidation of fatty acids in the liver".
In other words, acute excessive alcohol drinking causes liver injury through ethanol pre-exposure in stimulating the immune response in the production of inflammatory cytokines and induction of intoxication.
Other researchers suggested that acute excessive alcohol drinking can also cause liver injury by increasing gut permeability, leading to the translocation of endotoxins into the portal blood that facilitates the intoxication.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of acute alcohol-induced liver damage examined the artichoke(Cynara scolymus L.) used in traditional medicine with anti-oxidative and anti-inflammatory properties.
The study included mice group induced acute alcohol-induced liver injury by 40% alcohol (12 mL/kg body weight) administered orally 1 h after treated with an ethanolic extract from artichoke (0.4, 0.8, and 1.6 g/kg body weight) by gavage once daily.
After 10 consecutive days of treatment, artichoke extract significantly prevented elevated levels of oxidative stress and liver damage markers, and triglyceride, total cholesterol.
Artichoke extract also normalized the levels of antioxidants enzymes which was suppressed by the alcohol injection produced by the host.
According to the histopathological assays, artichoke attenuated degeneration, inflammatory infiltration, and necrosis of liver cells.
According to the Immunohistochemical analysis, artichoke also attenuated of receptor and protein associated with the production of proinflammatory cytokines in the liver tissues.
The results clearly supported the use of artichoke extract for the prevention and protection against acute alcohol-induced liver injury.
Dr. Tang X and colleagues said, "This finding is mainly attributed to its ability to attenuate oxidative stress and suppress the TLR4/NF-κB inflammatory pathway".
In order to reveal more information about artichoke anti acute liver damage, researchers examined the results of male albino Wistar rats selected for the study.
Male albino Wistar rats were divided into four equal groups of eight animals each. The first group was assigned as a control. Groups 2-4 were orally administered with ALE (300 mg/kg bw), Cd (CdCl2, 100 mg/L drinking water), and ALE plus Cd, respectively, daily for 4 weeks.
Before the treatment of ALE, Cd treatment rats exerted an increase of liver and kidney oxidative stress compared with the control rats.
The overexpression of proinflammatory cytokines also was found to increase significantly in Cd-treated rats compared to the control accompanied by the suppressed levels of antioxidant enzymes produced by the rats.
Combination treatment, Cd and ALE significantly improved immune response in the production of inflammatory cytokines, antioxidants produced by the host system and hepatorenal function by a significant decline liver injury marker.
Taken altogether, artichoke exerted a significant anti acute liver damage through a series of mechanisms that may be considered a functional remedy for the prevention and treatment of acute liver diseases, pending to the confirmation of larger sample size and multicancer human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Protective Effects of Ethanolic Extracts from Artichoke, an Edible Herbal Medicine, against Acute Alcohol-Induced Liver Injury in Mice by Tang X1, Wei R2, Deng A3, Lei T4. (PubMed)
(2) Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats by El-Boshy M1,2, Ashshi A3, Gaith M3, Qusty N3, Bokhary T4, AlTaweel N5,6, Abdelhady M. (PubMed)
(3) Acute Alcohol-Induced Liver Injury by Veronica L. Massey1 and Gavin E. Arteel. (PMC)
Acute alcohol-induced liver injury is a condition caused excessive alcohol drinking in a short term.
Acute alcohol binges have been found to induce acute liver toxicity and contribute to the chronicity of alcoholic liver disease (ALD).
The condition has been found increasingly in people aged 18–25, probably, due to severe CNS depression, which slows motor coordination and respiratory rates.
Believe it or not, over 50% of Americans consume alcohol, 23.1% of them participating in heavy and/or binge drinking at least once a month, leading to acute alcoholic liver toxicity in the initiation and progression of alcoholic liver disease.
In fact, heavy and/or binge drinking has been associated with the onset of steatosis or fatty liver caused by alcohol metabolism in the induction of liver fat accumulation.
Dr. Veronica L. Massey, the lead scientists, in the explanation of how alcoholic metabolism induced fatty liver, said, "Concentrations of alcohol can easily reach the mM range in the portal/hepatic circulation during alcohol consumption. In the process of metabolizing ethanol to acetate, two equivalents of reduced NADH are generated per equivalent of ethanol oxidized" and, "This metabolism robustly increases the ratio of NADH:NAD+ within the cell, which then inhibits the β-oxidation of fatty acids in the liver".
In other words, acute excessive alcohol drinking causes liver injury through ethanol pre-exposure in stimulating the immune response in the production of inflammatory cytokines and induction of intoxication.
Other researchers suggested that acute excessive alcohol drinking can also cause liver injury by increasing gut permeability, leading to the translocation of endotoxins into the portal blood that facilitates the intoxication.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of acute alcohol-induced liver damage examined the artichoke(Cynara scolymus L.) used in traditional medicine with anti-oxidative and anti-inflammatory properties.
The study included mice group induced acute alcohol-induced liver injury by 40% alcohol (12 mL/kg body weight) administered orally 1 h after treated with an ethanolic extract from artichoke (0.4, 0.8, and 1.6 g/kg body weight) by gavage once daily.
After 10 consecutive days of treatment, artichoke extract significantly prevented elevated levels of oxidative stress and liver damage markers, and triglyceride, total cholesterol.
Artichoke extract also normalized the levels of antioxidants enzymes which was suppressed by the alcohol injection produced by the host.
According to the histopathological assays, artichoke attenuated degeneration, inflammatory infiltration, and necrosis of liver cells.
According to the Immunohistochemical analysis, artichoke also attenuated of receptor and protein associated with the production of proinflammatory cytokines in the liver tissues.
The results clearly supported the use of artichoke extract for the prevention and protection against acute alcohol-induced liver injury.
Dr. Tang X and colleagues said, "This finding is mainly attributed to its ability to attenuate oxidative stress and suppress the TLR4/NF-κB inflammatory pathway".
In order to reveal more information about artichoke anti acute liver damage, researchers examined the results of male albino Wistar rats selected for the study.
Male albino Wistar rats were divided into four equal groups of eight animals each. The first group was assigned as a control. Groups 2-4 were orally administered with ALE (300 mg/kg bw), Cd (CdCl2, 100 mg/L drinking water), and ALE plus Cd, respectively, daily for 4 weeks.
Before the treatment of ALE, Cd treatment rats exerted an increase of liver and kidney oxidative stress compared with the control rats.
The overexpression of proinflammatory cytokines also was found to increase significantly in Cd-treated rats compared to the control accompanied by the suppressed levels of antioxidant enzymes produced by the rats.
Combination treatment, Cd and ALE significantly improved immune response in the production of inflammatory cytokines, antioxidants produced by the host system and hepatorenal function by a significant decline liver injury marker.
Taken altogether, artichoke exerted a significant anti acute liver damage through a series of mechanisms that may be considered a functional remedy for the prevention and treatment of acute liver diseases, pending to the confirmation of larger sample size and multicancer human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Protective Effects of Ethanolic Extracts from Artichoke, an Edible Herbal Medicine, against Acute Alcohol-Induced Liver Injury in Mice by Tang X1, Wei R2, Deng A3, Lei T4. (PubMed)
(2) Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats by El-Boshy M1,2, Ashshi A3, Gaith M3, Qusty N3, Bokhary T4, AlTaweel N5,6, Abdelhady M. (PubMed)
(3) Acute Alcohol-Induced Liver Injury by Veronica L. Massey1 and Gavin E. Arteel. (PMC)
Wednesday, November 6, 2019
Tomato Inhibits the Onset and progression of Non-Alcoholic Fatty Liver Disease (NAFLD)
Nonalcoholic fatty liver disease (NAFLD) is a chronic condition caused by fat accumulated in the liver over time, in the absence of excessive alcohol use.
The disease can be classified into the types of non-inflammatory fatty liver (NAFL) and inflammatory nonalcoholic steatohepatitis (NASH).
Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of cirrhosis and liver cancer.
According to world statistics, nonalcoholic fatty liver disease (NAFLD) is normally known as a disease of the Western world. However, due to the economic prosperity of Southeast Asian, the disease also was found in a large population in the cities, causing concerns of many scientists in the region.
According to the statistics, in the US, over 100 million people have non-alcoholic fatty liver disease and the condition is more double over the past 20 years. The disease also is the most prevalent liver disease in children.
Among the more affluent regions of China, the prevalence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 15%. The number may decrease substantially if the poor rural populations where obesity is non-existence are also taking into account.
The exact causes of NAFLD aren't well understood. Some researchers suggested that certain risk factors such as long-term use of certain medications, genetic preposition, insulin resistance, high cholesterol and triglycerides in the blood, polycystic ovary syndrome, metabolic syndrome, obesity, and type 2 diabetes are associated with the onset of the disease.
Recent studies also found that people with obstructive sleep apnea, underactive thyroid (hypothyroidism(10) and underactive pituitary gland (hypopituitarism) also at an increased risk of the NALFD.
Some researchers suggested that an unhealthy diet such as a high-fat diet may also have a strong implication on NAFLD(12)(13).
Dr. Jensen VS, the lead scientist in the study of high-fat diet-induced non-alcoholic fatty liver disease, wrote, "In humans and animal models, excessive intake of dietary fat, fructose, and cholesterol have been linked to the development of non-alcoholic fatty liver disease (NAFLD)"(13).
And, " Only HFr-fed rats developed dyslipidemia as characterized by higher levels of plasma triglycerides compared to all other groups (p < 0.0001). Hepatic dysfunction and inflammation was confirmed in HFD-fed rats by elevated levels of hepatic MCP-1 (p < 0.0001), TNF-alpha (p < 0.001) and plasma β-hydroxybutyrate (p < 0.0001), and in NASH-fed rats by elevated levels of hepatic MCP-1 (p < 0.01), increased hepatic macrophage infiltration (p < 0.001), and higher plasma levels of alanine aminotransferase (p < 0.0001) aspartate aminotransferase (p < 0.05), haptoglobin (p < 0.001) and TIMP-1 (p < 0.01) compared to Control"
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for the treatment of non-alcoholic fatty liver disease (NAFLD), researchers examined the effect of tomato juice consumption on high-fat diet-induced alterations in certain intestinal bacterial groups.
The study included a rat model with NAFLD induced by a high-fat diet that was randomly assigned to involving four experimental groups, including NA (standard diet and water), NL (standard diet and tomato juice), HA (high-fat diet and water) and HL (high-fat diet and tomato juice).
Rats with NAFLD were found to have an impaired gut microbiota profile observed by reducing the abundance of Bifidobacterium and Lactobacillus and increasing Enterobacteriaceae.
Futhermore, according to the tested analysis, NAFLD rat also showed reduced concentrations of propionate, butyrate and phenolic catabolites and an increased acetate to propionate (Ac : Pr) ratio.
In other words, levels of antioxidant enzymes in the gut also decreased by the in NAFLD induced by high-fat diet rats compared to NA and HA.
Oral administration of tomato juice partially ameliorated high-fat diet-induced disturbances, particularly by increasing Lactobacillus abundance and diminishing the Ac : Pr ratio.
More precisely, tomato juice protected the gut microbiome composition against the alternation induced NAFLD.
Researchers after taking into account co and confounders wrote, "(Tomato juice may be) a potential improvement of the metabolic pattern of NAFLD'.
Taken altogether, tomato may be considered a dietary supplement for the prevention and treatment of NAFLD, pending to large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A study of the prebiotic-like effects of tomato juice consumption in rats with diet-induced non-alcoholic fatty liver disease (NAFLD) by García-Alonso FJ1, González-Barrio R, Martín-Pozuelo G, Hidalgo N, Navarro-González I, Masuero D, Soini E, Vrhovsek U, Periago MJ. (PubMed)
(2) Non-Alcoholic Fatty Liver Disease (NAFLD) Treatment In Healthy Food Perspective by Kyle J. Norton
The disease can be classified into the types of non-inflammatory fatty liver (NAFL) and inflammatory nonalcoholic steatohepatitis (NASH).
Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of cirrhosis and liver cancer.
According to world statistics, nonalcoholic fatty liver disease (NAFLD) is normally known as a disease of the Western world. However, due to the economic prosperity of Southeast Asian, the disease also was found in a large population in the cities, causing concerns of many scientists in the region.
According to the statistics, in the US, over 100 million people have non-alcoholic fatty liver disease and the condition is more double over the past 20 years. The disease also is the most prevalent liver disease in children.
Among the more affluent regions of China, the prevalence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 15%. The number may decrease substantially if the poor rural populations where obesity is non-existence are also taking into account.
The exact causes of NAFLD aren't well understood. Some researchers suggested that certain risk factors such as long-term use of certain medications, genetic preposition, insulin resistance, high cholesterol and triglycerides in the blood, polycystic ovary syndrome, metabolic syndrome, obesity, and type 2 diabetes are associated with the onset of the disease.
Recent studies also found that people with obstructive sleep apnea, underactive thyroid (hypothyroidism(10) and underactive pituitary gland (hypopituitarism) also at an increased risk of the NALFD.
Some researchers suggested that an unhealthy diet such as a high-fat diet may also have a strong implication on NAFLD(12)(13).
Dr. Jensen VS, the lead scientist in the study of high-fat diet-induced non-alcoholic fatty liver disease, wrote, "In humans and animal models, excessive intake of dietary fat, fructose, and cholesterol have been linked to the development of non-alcoholic fatty liver disease (NAFLD)"(13).
And, " Only HFr-fed rats developed dyslipidemia as characterized by higher levels of plasma triglycerides compared to all other groups (p < 0.0001). Hepatic dysfunction and inflammation was confirmed in HFD-fed rats by elevated levels of hepatic MCP-1 (p < 0.0001), TNF-alpha (p < 0.001) and plasma β-hydroxybutyrate (p < 0.0001), and in NASH-fed rats by elevated levels of hepatic MCP-1 (p < 0.01), increased hepatic macrophage infiltration (p < 0.001), and higher plasma levels of alanine aminotransferase (p < 0.0001) aspartate aminotransferase (p < 0.05), haptoglobin (p < 0.001) and TIMP-1 (p < 0.01) compared to Control"
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for the treatment of non-alcoholic fatty liver disease (NAFLD), researchers examined the effect of tomato juice consumption on high-fat diet-induced alterations in certain intestinal bacterial groups.
The study included a rat model with NAFLD induced by a high-fat diet that was randomly assigned to involving four experimental groups, including NA (standard diet and water), NL (standard diet and tomato juice), HA (high-fat diet and water) and HL (high-fat diet and tomato juice).
Rats with NAFLD were found to have an impaired gut microbiota profile observed by reducing the abundance of Bifidobacterium and Lactobacillus and increasing Enterobacteriaceae.
Futhermore, according to the tested analysis, NAFLD rat also showed reduced concentrations of propionate, butyrate and phenolic catabolites and an increased acetate to propionate (Ac : Pr) ratio.
In other words, levels of antioxidant enzymes in the gut also decreased by the in NAFLD induced by high-fat diet rats compared to NA and HA.
Oral administration of tomato juice partially ameliorated high-fat diet-induced disturbances, particularly by increasing Lactobacillus abundance and diminishing the Ac : Pr ratio.
More precisely, tomato juice protected the gut microbiome composition against the alternation induced NAFLD.
Researchers after taking into account co and confounders wrote, "(Tomato juice may be) a potential improvement of the metabolic pattern of NAFLD'.
Taken altogether, tomato may be considered a dietary supplement for the prevention and treatment of NAFLD, pending to large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A study of the prebiotic-like effects of tomato juice consumption in rats with diet-induced non-alcoholic fatty liver disease (NAFLD) by García-Alonso FJ1, González-Barrio R, Martín-Pozuelo G, Hidalgo N, Navarro-González I, Masuero D, Soini E, Vrhovsek U, Periago MJ. (PubMed)
(2) Non-Alcoholic Fatty Liver Disease (NAFLD) Treatment In Healthy Food Perspective by Kyle J. Norton
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