Artichoke may be used as a natural ingredient to inhibit the overexpression of reactive oxygen species (ROS), according to studies.
Reactive oxygen species (ROS) or free radicals are highly reactive chemical species containing oxygen molecules. In other words, free radicals are unstable atoms with an unpaired electron in the outer ring.
Therefore, in order to become stable, free radicals must either donate or steal an electron from other atoms, leading to a chain reaction that can not be stopped until all electrons are paired or inhibited by antioxidants.
Believe it or not, free radicals in moderate amounts are needed for our body for cell signaling and activation of several transcriptional factors, apoptosis, immunity, and differentiation. However, overexpression of free radicles can cause damage to protein, lipid and cell alternation, leading a number of chronic illnesses, including cancer.
Free radicals are generated as metabolic by-products by biological systems. Environmental stressors (i.e., the air we breathe, UV, ionizing radiations, pollutants, and heavy metals) and xenochemicals are also found to contribute to the great increase of ROS production.
In a healthy individual, the production of free radicals is balanced by the antioxidant enzymes produced by the body.
Some researchers suggested that an unhealthy diet may also induce overexpression of free radicals through a number of mechanisms.
Dr. Vial G, the lead scientist said, "A high-fat diet results in both a decrease in mitochondrial quinone pool and a profound modification in mitochondrial lipid composition" and, "These changes appear to play a key role in the resulting inhibition of fatty acid oxidation and of mitochondrial oxidative-phosphorylation associated with an increased mitochondrial ROS production".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural free radical scavenger evaluated the scavenging capacity against the most physiologically relevant reactive oxygen species (ROS) and reactive nitrogen species (RNS) of 3 artichoke extract from the leaves.
According to the tested assays, all extracts of artichoke leaves processed a remarkable capacity to scavenge ROS and RNS with IC50 values in a low μg/mL range (3.4-43μg/mL).
In HUVEC cells, the preincubation of HUVEC cells with the artichoke extract at concentrations of 25-100 microg/mL for 24 h showed the complete inhibition of ROS generation induced by LPS which process biological effects on hosts infected with Gram-negative bacteria.
Where HUVEC cells are normally used for the study of the function and pathology of endothelial cells derived from the endothelium of veins from the umbilical cord.
Injection of the extracts also inhibited the lipid peroxidation in the tested HUVEC cells.
Artichoke also reduced the cell apoptosis caused by free radicals damage by inhibiting the ROS generation and reducing the function of cytochrome c, a component of the electron transport chain in mitochondria in triggering programmed cell death through apoptosis.
Taken altogether, artichoke may be considered a free radical scavenger for the prevention and treatment of diseases associated with oxidative stress, pending to the result of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Infusion, decoction and hydroalcoholic extracts of leaves from artichoke (Cynaracardunculus L. subsp. cardunculus) are effective scavengers of physiologically relevant ROS and RNS by Pistón M1, Machado I1, Branco CS2, Cesio V3, Heinzen H3, Ribeiro D4, Fernandes E4, Chisté RC5, Freitas M. (PubMed)
(2) The effect of artichoke (Cynara scolymus L.) extract on ROS generation in HUVEC cells by Juzyszyn Z1, Czerny B, Pawlik A, Droździk M. (PubMed)
(3) Effects of a high-fat diet on energy metabolism and ROS production in rat liver by Vial G1, Dubouchaud H, Couturier K, Cottet-Rousselle C, Taleux N, Athias A, Galinier A, Casteilla L, Leverve XM. (PubMed)
Sunday, November 10, 2019
The Effects of Herbal Andrographis On Common Cold
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chickenpox, etc.
Cold and flu are the most commonly occurring illnesses in the entire world, with more than 1 billion colds per year reported in the United States alone. The common cold is a self-limiting illness caused by any 1 of more than 200 viruses. Influenza is no minor illness. If you are senior or have a serious heart and lung disease, you are at the greatest risk for coming down with a dangerous case of flu because your immune system might not be strong enough to fend off the infection.
The Ingredients
Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.
The benefits
In United States, common old causes 189 million lost school days and Influenza infection leads of morbidity and mortality, accounting for 20-25 million doctor visits and 36,000 deaths per year, Andrographis paniculata and nutritional considerations (vitamins A and C, zinc, high lactoferrin whey protein, N-acetylcysteine, and DHEA) may help in the prevention and treatment of these conditions. In the study of Andrographis paniculataSHA-10 extract, had found to be a very effective supplement in reducing the prevalence and intensity of the symptoms in the uncomplicated common cold beginning at day two of treatment and its dried extract found in Kan Jang tablets, attributes a protective effect of 33%, against common colds during the winter period.
The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html
References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2) Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations by Roxas M, Jurenka J.(PubMed)
(3) Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study by Cáceres DD, Hancke JL, Burgos RA, Sandberg F, Wikman GK.(PubMed)
(4) Prevention of common colds with Andrographis paniculata dried extract. A Pilot double blind trial by Cáceres DD, Hancke JL, Burgos RA, Wikman GK. (PubMed)
Cold and flu are the most commonly occurring illnesses in the entire world, with more than 1 billion colds per year reported in the United States alone. The common cold is a self-limiting illness caused by any 1 of more than 200 viruses. Influenza is no minor illness. If you are senior or have a serious heart and lung disease, you are at the greatest risk for coming down with a dangerous case of flu because your immune system might not be strong enough to fend off the infection.
The Ingredients
Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.
The benefits
In United States, common old causes 189 million lost school days and Influenza infection leads of morbidity and mortality, accounting for 20-25 million doctor visits and 36,000 deaths per year, Andrographis paniculata and nutritional considerations (vitamins A and C, zinc, high lactoferrin whey protein, N-acetylcysteine, and DHEA) may help in the prevention and treatment of these conditions. In the study of Andrographis paniculataSHA-10 extract, had found to be a very effective supplement in reducing the prevalence and intensity of the symptoms in the uncomplicated common cold beginning at day two of treatment and its dried extract found in Kan Jang tablets, attributes a protective effect of 33%, against common colds during the winter period.
The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html
References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2) Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations by Roxas M, Jurenka J.(PubMed)
(3) Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study by Cáceres DD, Hancke JL, Burgos RA, Sandberg F, Wikman GK.(PubMed)
(4) Prevention of common colds with Andrographis paniculata dried extract. A Pilot double blind trial by Cáceres DD, Hancke JL, Burgos RA, Wikman GK. (PubMed)
Herbal Aloe Vera, the Natural Remedy for the Treatment Psoriasis
Herbal Aloe vera may be a potential therapeutic remedy for the prevention and treatment of psoriasis with no side effects, scientists found.
Psoriasis is a skin condition characterized by the speeding up the life cycle of skin cells, leading to the formation of scales and red patches that are itchy and sometimes painful.
Most common causes of psoriasis is a skin infection with an autoimmune disorder caused by the immune system attacking the skin tissue after bacterial and virus invasion or skin injury due to cut or scrape, an insect bite, or a severe sunburn.
Some researchers believe that the disorder can also be driven by the change of weather, illness, or stress.
Similar to other types of inflammation, it is a result of overexpression of the inflammatory cytokines produced during the course of skin injury and damage, leading to the death and damage of the skin cells that cause of skin cells in the affected area to turn over at a significantly faster rate than normal.
Several risk factors, according to epidemiological studies such as infection, skin injury, smoking, being overweight or obese and long-term use of certain medications including beta-blockers used for the treatment of hypertension are involved in the initiation and progression of psoriasis.
Genetic preposition such as HLA-C06:02 environmental and lifestyle factors, such as certain foods and infections, are some risk factors of psoriasis.
According to statistic, these people have a 30% increased risk for the development of the condition.
Therefore, identifying the trigger potentials may be important for these patients to develop strategies the management and prevention of psoriasis.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.
The herbal plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.
The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
With an aim to find a natural ingredient or herbal medicine for the treatment of psoriasis, with no side effects, researchers evaluated the Aloe vera gel, used traditionally for the treatment of skin diseases, including psoriasis, through assessing the ethanolic extract of the gel in a mouse tail model of psoriasis.
The extract displayed a significant differentiation in the epidermis, as seen from its degree of orthokeratosis (85.07 ± 3.36%) when compared with the negative control (17.30 ± 4.09%).
Furthermore, the extracted gel was found to be equivalent to the effect of the standard positive control, tazarotene (0.1%) gel, which showed a 90.03 ± 2.00% degree of orthokeratosis.
Moreover, the ethanolic extract of Aloe vera leaf gel also produced a significant increase in relative epidermal thickness when compared with the control group, and no change in the standard tazarotene.
Dr. Dhanabal SP, the lead scientist said, "the extract showed an overall antipsoriatic activity of 81.95%, compared with 87.94 for tazarotene, in the mouse tail model for psoriasis".
Additionally, in the examine the topical aloe vera (AV) used to treat various skin conditions, including psoriasis, researchers launched a randomized, comparative, double-blind, 8-week study.
80 patients included in the randomized study received AV or 0.1% TA cream.
The patient's clinical responses were evaluated using the Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI).
After 8 weeks of treatment, researchers discovered the mean PASI score decreased from 11.6 to 3.9 (-7.7) in the AV group and from 10.9 to 4.3 (-6.6) in the TA group. Between-group difference was 1.1 (95% confidence interval -2.13, -0.16, P = 0.0237.
And, the mean DLQI score decreased from 8.6 to 2.5 (-6.1) in the AV group and from 8.1 to 2.3 (-5.8) in the TA group.
Between-group difference was 0.3 (95% confidence interval -1.18, -0.64, P = 0.5497).
In the final report, Dr. Choonhakarn C, the lead scientist wrote, "AV cream may be more effective than 0.1% TA cream in reducing the clinical symptoms of psoriasis; however, both treatments have similar efficacy in improving the quality of life of patients with mild to moderate psoriasis".
The findings suggested that herbal Aloe vera may be considered a functional remedy of the treatment of psoriasis topically with no side effects.
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Evaluation of the antipsoriatic activity of Aloe vera leaf extract using a mouse tail model of psoriasis by Dhanabal SP, Priyanka Dwarampudi L, Muruganantham N, Vadivelan R.(PubMed)
(2) A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis by Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P.(PubMed)
Psoriasis is a skin condition characterized by the speeding up the life cycle of skin cells, leading to the formation of scales and red patches that are itchy and sometimes painful.
Most common causes of psoriasis is a skin infection with an autoimmune disorder caused by the immune system attacking the skin tissue after bacterial and virus invasion or skin injury due to cut or scrape, an insect bite, or a severe sunburn.
Some researchers believe that the disorder can also be driven by the change of weather, illness, or stress.
Similar to other types of inflammation, it is a result of overexpression of the inflammatory cytokines produced during the course of skin injury and damage, leading to the death and damage of the skin cells that cause of skin cells in the affected area to turn over at a significantly faster rate than normal.
Several risk factors, according to epidemiological studies such as infection, skin injury, smoking, being overweight or obese and long-term use of certain medications including beta-blockers used for the treatment of hypertension are involved in the initiation and progression of psoriasis.
Genetic preposition such as HLA-C06:02 environmental and lifestyle factors, such as certain foods and infections, are some risk factors of psoriasis.
According to statistic, these people have a 30% increased risk for the development of the condition.
Therefore, identifying the trigger potentials may be important for these patients to develop strategies the management and prevention of psoriasis.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.
The herbal plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.
The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
With an aim to find a natural ingredient or herbal medicine for the treatment of psoriasis, with no side effects, researchers evaluated the Aloe vera gel, used traditionally for the treatment of skin diseases, including psoriasis, through assessing the ethanolic extract of the gel in a mouse tail model of psoriasis.
The extract displayed a significant differentiation in the epidermis, as seen from its degree of orthokeratosis (85.07 ± 3.36%) when compared with the negative control (17.30 ± 4.09%).
Furthermore, the extracted gel was found to be equivalent to the effect of the standard positive control, tazarotene (0.1%) gel, which showed a 90.03 ± 2.00% degree of orthokeratosis.
Moreover, the ethanolic extract of Aloe vera leaf gel also produced a significant increase in relative epidermal thickness when compared with the control group, and no change in the standard tazarotene.
Dr. Dhanabal SP, the lead scientist said, "the extract showed an overall antipsoriatic activity of 81.95%, compared with 87.94 for tazarotene, in the mouse tail model for psoriasis".
Additionally, in the examine the topical aloe vera (AV) used to treat various skin conditions, including psoriasis, researchers launched a randomized, comparative, double-blind, 8-week study.
80 patients included in the randomized study received AV or 0.1% TA cream.
The patient's clinical responses were evaluated using the Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI).
After 8 weeks of treatment, researchers discovered the mean PASI score decreased from 11.6 to 3.9 (-7.7) in the AV group and from 10.9 to 4.3 (-6.6) in the TA group. Between-group difference was 1.1 (95% confidence interval -2.13, -0.16, P = 0.0237.
And, the mean DLQI score decreased from 8.6 to 2.5 (-6.1) in the AV group and from 8.1 to 2.3 (-5.8) in the TA group.
Between-group difference was 0.3 (95% confidence interval -1.18, -0.64, P = 0.5497).
In the final report, Dr. Choonhakarn C, the lead scientist wrote, "AV cream may be more effective than 0.1% TA cream in reducing the clinical symptoms of psoriasis; however, both treatments have similar efficacy in improving the quality of life of patients with mild to moderate psoriasis".
The findings suggested that herbal Aloe vera may be considered a functional remedy of the treatment of psoriasis topically with no side effects.
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Evaluation of the antipsoriatic activity of Aloe vera leaf extract using a mouse tail model of psoriasis by Dhanabal SP, Priyanka Dwarampudi L, Muruganantham N, Vadivelan R.(PubMed)
(2) A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis by Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P.(PubMed)
Herbal Anise, the Best Potential and Natural Remedy for Tongue Cancer with No Side Effects
Scientists may have found a herbal remedy for the prevention and treatment of tongue cancer with no side effects, according to studies.
Tongue cancers is a medical condition characterized by abnormal cell growth in the tongue, due to the alternation of cell DNA.
Most cases of cancer start in the cell of the inner lining tissue of the tongue. At stage 0, cancer cells are not found in the deeper layers of tissue, therefore, most patients at this stage may not experience any symptoms.
At the advanced stage, cancerous cells may travel a distance away from the tongue to infect other healthy tissues or organs through the circulation of fluids and blood, leading to secondary metastasis.
Most common secondary metastasis of tongue cancer in the mouth and muscle surrounding the mouth.
In 2018, approximately 17, 000 new cases of tongue cancer were diagnosed, representing 1% of all cancer cases in the US. Tongue cancer also causes the death of 2,500 people in the country.
The lifetime risk of tongue cancer is 0.4 % including men and women, based on 2013-2015 data. The 5 years survival of all stages of tongue cancer is 65.8%, according to the National Cancer Institute.
If you experience symptoms of a persistent red or white patch on your tongue, a tongue ulcer with persists pain that is not healed in 3 weeks, mouth numbness a sore throat with persistent bleeding from your tongue and lumps that do not go away, you may have tongue cancer. Please check with your doctor to rule out the possibility.
According to the report by the National Institute of Health, “Men who have performed oral sex on five or more women are at greater risk of developing head and neck cancer, especially if they smoke,” the Evening Standard reports.
This story is based on a US study that looked at 9,425 people aged 20 to 59 who provided information about their number of oral sex partners and were tested for oral human papillomavirus (HPV).
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to Egypt and the Mediterranean region.
The popular herb has been used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, antispasmodic, carminative, digestive, expectorant, stimulant, and tonic agent to treat head-lice and mites, increase blood pressure, prevent formation of gas in the gastrointestinal tract and menstrual cramps, etc.
Besides the main ingredient Anethole, herbal Anise also contains, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
With an aim to discover a natural ingredient or whole food for the treatment of tongue squamous carcinoma with no side effects researchers at the China Medical University, assessed the effects of safrole, one of important food-borne phytotoxin of herbal Anise.
Injection of safrole showed a significant effect in inducing apoptosis in human tongue squamous carcinoma SCC-4 cells.
Safrole-induced apoptosis was attributed to stimulate the function of a protein associated with the secured cell death pathways and inhibit the anti-apoptotic protein expression.
These results were also observed through the ratio of the expression of apoptotic and anti-apoptotic proteins found after injection of safrole.
According to the real-time PCR assay, safrole also promoted the mRNA expressions of proteins involved in the mediation of mitochondrial events of apoptosis in SCC-4 cells.
Dr. the lead scientist, wrote in the report, "Safrole is a cytotoxic effect in human tongue squamous carcinoma SCC-4 cells by inducing apoptosis. The induction of apoptosis of SCC-4 cells by safrole is involved in mitochondria- and caspase-dependent signal pathways".
Additonally in the examining aloe-emodin, one of the anthraquinones found in the anise seed, researchers assessed the anti-cancer effect of aloe-emodin on human tongue squamous carcinoma SCC-4 cells.
Injection of aloe-emodin induced cell death through cell cycle arrest and apoptosis in a dose- and time-dependent manner.
Treatment with 30 microM of aloe-emodin led to cell cycle arrest through activation of the protein involved tumor suppression and suppressed the proteins associated with regulating progression through the cell cycle.
Furthermore, aloe-emodin promoted the release of apoptosis through several inducing factors (AIF) (including endonuclease G (Endo G), procaspase-9 and cytochrome c from the mitochondria via a loss of the mitochondrial membrane potential (DeltaPsi(m))).
Moreover, injection of the free radical scavenger N-acetylcysteine (NAC) and caspase inhibitors markedly blocked aloe-emodin-induced apoptosis.
Taken altogether, herbal Anise processed bioactive compounds safrole and aloe-emodin may be considered a functional herb for the prevention and combined with primary therapy for the treatment of tongue squamous carcinoma.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Safrole induces cell death in human tongue squamous cancer SCC-4 cells through mitochondria-dependent caspase activation cascade apoptotic signaling pathways by Yu FS, Huang AC, Yang JS, Yu CS, Lu CC, Chiang JH, Chiu CF, Chung JG. (PubMed)
(2) Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells by Chiu TH, Lai WW, Hsia TC, Yang JS, Lai TY, Wu PP, Ma CY, Yeh CC, Ho CC, Lu HF, Wood WG, Chung JG.(PubMed)
Tongue cancers is a medical condition characterized by abnormal cell growth in the tongue, due to the alternation of cell DNA.
Most cases of cancer start in the cell of the inner lining tissue of the tongue. At stage 0, cancer cells are not found in the deeper layers of tissue, therefore, most patients at this stage may not experience any symptoms.
At the advanced stage, cancerous cells may travel a distance away from the tongue to infect other healthy tissues or organs through the circulation of fluids and blood, leading to secondary metastasis.
Most common secondary metastasis of tongue cancer in the mouth and muscle surrounding the mouth.
In 2018, approximately 17, 000 new cases of tongue cancer were diagnosed, representing 1% of all cancer cases in the US. Tongue cancer also causes the death of 2,500 people in the country.
The lifetime risk of tongue cancer is 0.4 % including men and women, based on 2013-2015 data. The 5 years survival of all stages of tongue cancer is 65.8%, according to the National Cancer Institute.
If you experience symptoms of a persistent red or white patch on your tongue, a tongue ulcer with persists pain that is not healed in 3 weeks, mouth numbness a sore throat with persistent bleeding from your tongue and lumps that do not go away, you may have tongue cancer. Please check with your doctor to rule out the possibility.
According to the report by the National Institute of Health, “Men who have performed oral sex on five or more women are at greater risk of developing head and neck cancer, especially if they smoke,” the Evening Standard reports.
This story is based on a US study that looked at 9,425 people aged 20 to 59 who provided information about their number of oral sex partners and were tested for oral human papillomavirus (HPV).
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to Egypt and the Mediterranean region.
The popular herb has been used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, antispasmodic, carminative, digestive, expectorant, stimulant, and tonic agent to treat head-lice and mites, increase blood pressure, prevent formation of gas in the gastrointestinal tract and menstrual cramps, etc.
Besides the main ingredient Anethole, herbal Anise also contains, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
With an aim to discover a natural ingredient or whole food for the treatment of tongue squamous carcinoma with no side effects researchers at the China Medical University, assessed the effects of safrole, one of important food-borne phytotoxin of herbal Anise.
Injection of safrole showed a significant effect in inducing apoptosis in human tongue squamous carcinoma SCC-4 cells.
Safrole-induced apoptosis was attributed to stimulate the function of a protein associated with the secured cell death pathways and inhibit the anti-apoptotic protein expression.
These results were also observed through the ratio of the expression of apoptotic and anti-apoptotic proteins found after injection of safrole.
According to the real-time PCR assay, safrole also promoted the mRNA expressions of proteins involved in the mediation of mitochondrial events of apoptosis in SCC-4 cells.
Dr. the lead scientist, wrote in the report, "Safrole is a cytotoxic effect in human tongue squamous carcinoma SCC-4 cells by inducing apoptosis. The induction of apoptosis of SCC-4 cells by safrole is involved in mitochondria- and caspase-dependent signal pathways".
Additonally in the examining aloe-emodin, one of the anthraquinones found in the anise seed, researchers assessed the anti-cancer effect of aloe-emodin on human tongue squamous carcinoma SCC-4 cells.
Injection of aloe-emodin induced cell death through cell cycle arrest and apoptosis in a dose- and time-dependent manner.
Treatment with 30 microM of aloe-emodin led to cell cycle arrest through activation of the protein involved tumor suppression and suppressed the proteins associated with regulating progression through the cell cycle.
Furthermore, aloe-emodin promoted the release of apoptosis through several inducing factors (AIF) (including endonuclease G (Endo G), procaspase-9 and cytochrome c from the mitochondria via a loss of the mitochondrial membrane potential (DeltaPsi(m))).
Moreover, injection of the free radical scavenger N-acetylcysteine (NAC) and caspase inhibitors markedly blocked aloe-emodin-induced apoptosis.
Taken altogether, herbal Anise processed bioactive compounds safrole and aloe-emodin may be considered a functional herb for the prevention and combined with primary therapy for the treatment of tongue squamous carcinoma.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Safrole induces cell death in human tongue squamous cancer SCC-4 cells through mitochondria-dependent caspase activation cascade apoptotic signaling pathways by Yu FS, Huang AC, Yang JS, Yu CS, Lu CC, Chiang JH, Chiu CF, Chung JG. (PubMed)
(2) Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells by Chiu TH, Lai WW, Hsia TC, Yang JS, Lai TY, Wu PP, Ma CY, Yeh CC, Ho CC, Lu HF, Wood WG, Chung JG.(PubMed)
Herbal Alfalfa, the Neuroprotective Natural Whole Food
Alfalfa is found to express neuroprotective effects against acute and progressive neurodegenerative disorders.
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc. North Americal aboriginal has used Alfalfa seed as food, such as making bread and mush.
Neuroprotection is the action to preserve the neuronal structure and/or function of the brain, particularly in the delay of neurodegenerative diseases and enhanced integrity of neurons.
According to the L.R. Institute of Pharmacy, methanol extract of Medicago sativa (MS) induced neuroprotective effect through antioxidant and anti-inflammatory activities against ischemia and reperfusion-induced cerebral injury in mice as free radicals expression are elevated with deletion of antioxidants, such as glutathione (GSH), superoxide dismutase (SOD) and total tissue sulfhydryl (T-SH) groups.
Indeed, mice treated with Medicago sativa (MS) exhibited significantly scavenged free radicals activity against a stable radical 1,1-diphenyl-2-picrylhydrazyl and O(•-) (2) and also inhibited XD/XO conversion and resultant O(•-) (2) production.
Dr. Bora KS, the lead researchers said, " treatment with MS enhances the antioxidant defense against BCAO-induced global cerebral ischemia and exhibits neuroprotective activity".
Furthermore, in the review of 117 references compiled from major databases as Chemical Abstracts, Science Direct, SciFinder, PubMed, Dr. Dukes Phytochemical and Ethnobotany, CIMER, and InteliHealth, M. sativa seems to hold great potential for various biological activities, including heart disease and neuroprotective effects, attributed to some major classes of phytoconstituents, including
saponins, flavonoids, phytoestrogens, coumarins, alkaloids, amino acids, phytosterols, vitamins, digestive enzymes, and terpenes.
With all the available scientific literature indicated above, alfalfa may attract the attention of natural product researchers to focus on the unexplored therapeutic potential of M. sativa, particular in the neuroprotective area.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult by Bora KS1, Sharma A.(PubMed)
(2) Phytochemical and pharmacological potential of Medicago sativa: a review by Bora KS1, Sharma A.(PubMed)
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc. North Americal aboriginal has used Alfalfa seed as food, such as making bread and mush.
Neuroprotection is the action to preserve the neuronal structure and/or function of the brain, particularly in the delay of neurodegenerative diseases and enhanced integrity of neurons.
According to the L.R. Institute of Pharmacy, methanol extract of Medicago sativa (MS) induced neuroprotective effect through antioxidant and anti-inflammatory activities against ischemia and reperfusion-induced cerebral injury in mice as free radicals expression are elevated with deletion of antioxidants, such as glutathione (GSH), superoxide dismutase (SOD) and total tissue sulfhydryl (T-SH) groups.
Indeed, mice treated with Medicago sativa (MS) exhibited significantly scavenged free radicals activity against a stable radical 1,1-diphenyl-2-picrylhydrazyl and O(•-) (2) and also inhibited XD/XO conversion and resultant O(•-) (2) production.
Dr. Bora KS, the lead researchers said, " treatment with MS enhances the antioxidant defense against BCAO-induced global cerebral ischemia and exhibits neuroprotective activity".
Furthermore, in the review of 117 references compiled from major databases as Chemical Abstracts, Science Direct, SciFinder, PubMed, Dr. Dukes Phytochemical and Ethnobotany, CIMER, and InteliHealth, M. sativa seems to hold great potential for various biological activities, including heart disease and neuroprotective effects, attributed to some major classes of phytoconstituents, including
saponins, flavonoids, phytoestrogens, coumarins, alkaloids, amino acids, phytosterols, vitamins, digestive enzymes, and terpenes.
With all the available scientific literature indicated above, alfalfa may attract the attention of natural product researchers to focus on the unexplored therapeutic potential of M. sativa, particular in the neuroprotective area.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult by Bora KS1, Sharma A.(PubMed)
(2) Phytochemical and pharmacological potential of Medicago sativa: a review by Bora KS1, Sharma A.(PubMed)
Saturday, November 9, 2019
Turmeric Bioactive compound Curcumin, the Potential Treatment for Reducing Radiation Dermatitis Severity in Cancer Patients
Radiation dermatitis is skin damage caused by exposure to radiation. The condition is often found in patients with radiotherapy for the treatment of cancer.
According to statistics, approximately 85% of patients with radiotherapy are affected by the symptoms of moderate-to-severe skin reactions, particularly in the first 2 weeks of the treatment.
Depending on the period of exposure and levels of skin damage, some patients with radiation of dermatitis may experience symptoms of mild skin redness, itchiness, peeling, moistness,... and blistering
In severe cases, patients may also induce painful broken skin, that prone to infection.
If you are treated with radiotherapy, you make sure that you know all the side effects for preventive measures.
Believe it or not, patients with certain medical conditions, inclduing skin disease, obesity
malnutrition, infectious diseases, and diabetes are more prone to radiation dermatitis, compared to those who do not.
Most cases of radiation dermatitis are treated successfully by topical steroid cream often prescribed by radiologists. However, if the topical cream failed, antibiotics, silver leaf nylon dressing may be prescribed to reduce symptoms and prevent infection.
Dr. Benoîte Méry, the lead scientist in the examined the risk of skin damage in breast cancer patients who were treated by radiation wrote, "54 patients were enrolled in 2013. Eight patients (14.8%) had grade ≥2 toxicity. The average weight and chest sizes were 65.5 kg and 93.6 cm, respectively. Bra cup size is significantly associated with a risk of grade 2 dermatitis [odds ratio (OR) 3.46, 95% confidence interval (CI) (1.29–11.92), p = 0.02]. Anthropometric breast fat mass measurements, such as thickness of left [OR 2.72, 95% CI (1.08–8.26), p = 0.04] and right [OR 2.45, 95% CI (0.99–7.27), p = 0.05] axillary fat, is correlated with an increased risk".
And, "Breast size and its different anthropometric measurements (thickness of left and right axillary fat, nipple-to-pectoral muscle distance) are correlated with the risk of skin toxicity".
The results suggested that other parameters, such as the area treated with radiation must also be taken into account of radiation dermatitis.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a skincare product with no side effects, researchers reviewed the chemistry of turmeric on radiation dermatitis occurred in 95% of patients with radiation therapy (RT) for cancer.
The multisite, randomized, double-blinded, placebo-controlled trial included 686 breast cancer patients received four 500-mg capsules of placebo or curcumin three times daily throughout their prescribed course of RT until 1-week post-RT.
According to the severity (RDS) at the end of RT, using the RDS scale, compared to placebo, oral curcumin did not reduce radiation dermatitis severity at the end of RT.
However, the curcumin group showed an improvement in fewer patients with RDS > 3.0.
In other words, oral curcumin exerted a prominent effect in inducing a trend toward reduced severity compared to the non-curcumin treated group.
According to the reports from participants, curcumin also showed a change in pain, symptoms, and quality of life, although they were not statistically significant between arms.
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for reducing radiation dermatitis severity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Turmeric: A condiment, cosmetic and cure by Gopinath H1, Karthikeyan K. (PubMed)
(2) Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients by Ryan Wolf J1,2,3, Heckler CE4,5, Guido JJ4,5, Peoples AR4, Gewandter JS6, Ling M7, Vinciguerra VP8, Anderson T9, Evans L10, Wade J11, Pentland AP12, Morrow GR. (PubMed)
(3) Correlation between anthropometric parameters and acute skin toxicity in breast cancer radiotherapy patients: a pilot assessment study by Benoîte Méry, MD,1 Alexis Vallard, MD,2 Jane-Chloé Trone, MD,2 Cécile Pacaut, MD,1Jean-Baptiste Guy, MD,2 Sophie Espenel, MD,2 Julien Langrand-Escure, MD,2 Edouard Ollier, MD,3 Guoping Wang, MD,1 Peng Diao, MD,2 Lise Bigot,2 Sylvie Mengue Ndong, MD,2Claire Bosacki, MD,1 Majed Ben Mrad, MD,2 and Nicolas Magné, MD, PhD. (PMC)
According to statistics, approximately 85% of patients with radiotherapy are affected by the symptoms of moderate-to-severe skin reactions, particularly in the first 2 weeks of the treatment.
Depending on the period of exposure and levels of skin damage, some patients with radiation of dermatitis may experience symptoms of mild skin redness, itchiness, peeling, moistness,... and blistering
In severe cases, patients may also induce painful broken skin, that prone to infection.
If you are treated with radiotherapy, you make sure that you know all the side effects for preventive measures.
Believe it or not, patients with certain medical conditions, inclduing skin disease, obesity
malnutrition, infectious diseases, and diabetes are more prone to radiation dermatitis, compared to those who do not.
Most cases of radiation dermatitis are treated successfully by topical steroid cream often prescribed by radiologists. However, if the topical cream failed, antibiotics, silver leaf nylon dressing may be prescribed to reduce symptoms and prevent infection.
Dr. Benoîte Méry, the lead scientist in the examined the risk of skin damage in breast cancer patients who were treated by radiation wrote, "54 patients were enrolled in 2013. Eight patients (14.8%) had grade ≥2 toxicity. The average weight and chest sizes were 65.5 kg and 93.6 cm, respectively. Bra cup size is significantly associated with a risk of grade 2 dermatitis [odds ratio (OR) 3.46, 95% confidence interval (CI) (1.29–11.92), p = 0.02]. Anthropometric breast fat mass measurements, such as thickness of left [OR 2.72, 95% CI (1.08–8.26), p = 0.04] and right [OR 2.45, 95% CI (0.99–7.27), p = 0.05] axillary fat, is correlated with an increased risk".
And, "Breast size and its different anthropometric measurements (thickness of left and right axillary fat, nipple-to-pectoral muscle distance) are correlated with the risk of skin toxicity".
The results suggested that other parameters, such as the area treated with radiation must also be taken into account of radiation dermatitis.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a skincare product with no side effects, researchers reviewed the chemistry of turmeric on radiation dermatitis occurred in 95% of patients with radiation therapy (RT) for cancer.
The multisite, randomized, double-blinded, placebo-controlled trial included 686 breast cancer patients received four 500-mg capsules of placebo or curcumin three times daily throughout their prescribed course of RT until 1-week post-RT.
According to the severity (RDS) at the end of RT, using the RDS scale, compared to placebo, oral curcumin did not reduce radiation dermatitis severity at the end of RT.
However, the curcumin group showed an improvement in fewer patients with RDS > 3.0.
In other words, oral curcumin exerted a prominent effect in inducing a trend toward reduced severity compared to the non-curcumin treated group.
According to the reports from participants, curcumin also showed a change in pain, symptoms, and quality of life, although they were not statistically significant between arms.
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for reducing radiation dermatitis severity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Turmeric: A condiment, cosmetic and cure by Gopinath H1, Karthikeyan K. (PubMed)
(2) Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients by Ryan Wolf J1,2,3, Heckler CE4,5, Guido JJ4,5, Peoples AR4, Gewandter JS6, Ling M7, Vinciguerra VP8, Anderson T9, Evans L10, Wade J11, Pentland AP12, Morrow GR. (PubMed)
(3) Correlation between anthropometric parameters and acute skin toxicity in breast cancer radiotherapy patients: a pilot assessment study by Benoîte Méry, MD,1 Alexis Vallard, MD,2 Jane-Chloé Trone, MD,2 Cécile Pacaut, MD,1Jean-Baptiste Guy, MD,2 Sophie Espenel, MD,2 Julien Langrand-Escure, MD,2 Edouard Ollier, MD,3 Guoping Wang, MD,1 Peng Diao, MD,2 Lise Bigot,2 Sylvie Mengue Ndong, MD,2Claire Bosacki, MD,1 Majed Ben Mrad, MD,2 and Nicolas Magné, MD, PhD. (PMC)
Herbal Arctostaphylos uva-ursi and antiinflammatory activities
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe. The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stones, pelvic pain, etc.
Inflammation is a condition of Immune system self-protection to remove harmful stimuli, including damaged cells, irritants, pathogens... from our body.
The Ingredients It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
The benefits
Water extract (UW-ext) collected from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf), is found to exhibit its anti-inflammatory effects in ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema. arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng., when combined with and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis, found to be effective as arbutin may increase the inhibitory action of indomethacin on PC-CD, SRBC-DTH, carrageenin-induced edema, and adjuvant-induced arthritis, but further investigations are required to understand the mechanism involved. Another study also indicated that 50% methanolic extract (U-ext), containing arbutin, possesses a therapeutic effect against immuno-inflammation induced by picryl chloride (PC-CD) and also increases the inhibitory effect of prednisolone.
The Side effect
1. Overdoses may cause gastrointestinal discomfort, including cause nausea, vomiting, etc. and fever, chills, severe back pain, ringing in the ears, etc.
2. The herb may interact with other medications, including a diuretic
3. Do not use the herb in newborns, children or if you are pregnant or breastfeeding without approval from the related field specialist.
4. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html
References
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. Combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylosuva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)
Inflammation is a condition of Immune system self-protection to remove harmful stimuli, including damaged cells, irritants, pathogens... from our body.
The Ingredients It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
The benefits
Water extract (UW-ext) collected from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf), is found to exhibit its anti-inflammatory effects in ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema. arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng., when combined with and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis, found to be effective as arbutin may increase the inhibitory action of indomethacin on PC-CD, SRBC-DTH, carrageenin-induced edema, and adjuvant-induced arthritis, but further investigations are required to understand the mechanism involved. Another study also indicated that 50% methanolic extract (U-ext), containing arbutin, possesses a therapeutic effect against immuno-inflammation induced by picryl chloride (PC-CD) and also increases the inhibitory effect of prednisolone.
The Side effect
1. Overdoses may cause gastrointestinal discomfort, including cause nausea, vomiting, etc. and fever, chills, severe back pain, ringing in the ears, etc.
2. The herb may interact with other medications, including a diuretic
3. Do not use the herb in newborns, children or if you are pregnant or breastfeeding without approval from the related field specialist.
4. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html
References
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. Combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylosuva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)
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