Herbal aloe vera may be used for speeding up the skin wound healing with no side effects, some researchers suggested.
Wound healing is the natural process of repair of skin damage and injury.
The process of skin healing in humans is gone through several stages. First, the immune system after sensing the skin wound activates the immune first-line defense stimulating the constriction of the blood vessel to reduce blood flow, activate platelets, and many different clotting factors to cover the wound area.
Then, the white blood cells also up-regulate the proteins associated with the production of proinflammatory cytokines to the site of infection to kill off all the invasive organisms.
In most cases, due to the overproduction of proinflammatory cytokines, patients may experience symptoms of fever, and localized pain, redness, and swelling.
Furthermore, the production of pro-inflammatory cytokines in some case can cause the death of nearby healthy cells, leading to the formation of irreversible scars, as seen in the liver.
After the inflammatory phase, the new blood vessels are formed and the new granulation tissues are built.
The final phase of the wound healing is involved in the remodeling of collagen from type III to type I cellular activity reduces.
If the process of skin healing is interrupted, it may lead to abnormal cell membrane repair, a major cause of skin scars.
MG53 is a protein involved in tissue repair and regeneration and also considered a facilitator of rapid injury repair, a mediator of cell migration, and a modulator of myofibroblast differentiation during wound healing. The defection and down-regulation of MG53 protein may delay wound healing and abnormal scarring.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan.
It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.
The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.
On finding the natural compound or remedy for speeding up the treatment of wound healing, researchers examined the efficacy of aloe vera through searching the data of online medical literature.
Only controlled clinical trials for burn healing were included. There were no restrictions on any language of publication. Only 4 Four with a total of 371 patients were included in this review.
According to the meta-analysis using the duration of wound healing as an outcome measure, the healing time of the aloe vera group was 8.79 days shorter than those in the control group.
The cumulative evidence support that aloe vera can be an effective intervention used in burn wound healing for first to second-degree burns.
Furthermore, in order to maximize the effect of Aloe vera in wound healing, researchers examined the formulate and optimize a herbal gel of Aloe vera extract containing Carbopol 934 as a gelling agent.
During the observation of differences in wound healing between the various treatments when compared to the control group. researchers found that tissue hyperplasia was lower in the control group compared to the other treated groups.
In animals group treated with gel, exerted an 80.14% healing up to 14(th) day compared to the untreated group I (control) animals of showed 52.68%.
Control group animals also showed inflammation and pus formation up to 5(th) day of study, compared to none in the treatment group.
These results supported the use of topical application of Carbopol 934 gel containing Aloe vera extract on the healing of skin wounds.
Taken altogether, herbal Aloe vera may be considered a functional topical remedy for the treatment of skin wound, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The efficacy of aloe vera used for burn wound healing: a systematic review by Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C.(PubMed)
(2) Aloe vera for treating acute and chronic wounds. by Dat AD, Poon F, Pham KB, Doust J.(PubMed)
(3) Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study, by Eshghi F, Hosseinimehr SJ, Rahmani N, Khademloo M, Norozi MS, Hojati O.(PubMed)
(4) Formulation development, optimization and evaluation of aloe vera gel for wound healing by Khan AW, Kotta S, Ansari SH, Sharma RK, Kumar A, Ali J.(PubMed)
(5)
Modulation of Wound Healing and Scar Formation by MG53 Protein-mediated Cell Membrane Repair by Haichang Li,‡,1,2 Pu Duann,‡,1 Pei-Hui Lin,‡ Li Zhao,‡§ Zhaobo Fan,¶ Tao Tan,‡§ Xinyu Zhou,‡Mingzhai Sun,‡ Minghuan Fu,¶ Matthew Orange,‖ Matthew Sermersheim,‡ Hanley Ma,‡**Duofen He,‡‡ Steven M. Steinberg,‡ Robert Higgins,‡ Hua Zhu,‡ Elizabeth John,§Chunyu Zeng,‡‡ Jianjun Guan,¶ and Jianjie Ma. (PMC)
Saturday, November 16, 2019
Bromelain, the Best Natural Remedy for Reducing Pain and Swelling
Pain and swelling is a natural response of the immune and nervous system after a wound or injury by inducing the production of proinflammatory cytokines.
In the acute of infection, after sensing a wound and injury of the body, the immune first lines of white blood cell defense stimulate the production of blood palette to the infected area with an aim to cover the wound or injury and the inflammatory cytokines to kill off organisms trying to enter the body through the opening.
Please note that overexpression of proinflammatory cytokines in this phase has been found to cause abnormal healing with the formation of scars.
The acute phase of infection arrives and leaves quickly as it is resolved quickly by the body.
However, chronic infection is a result of an immune system that can not kill off all infectious organisms in the acute phase of infection, leading to chronic inflammation that lasts a long time, such as months or years.
Swelling and pain on the joints are one of the most common symptoms in patients with arthritis, particularly in rheumatoid arthritis (RA).
However, some cases of swelling accompanied by symptoms that do not associate to the injury such as fatigue, loss of appetite, and weight gain may be an indication of cancer, heart, liver, or kidney disease.
If you experience some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
Most cases of pain and swelling of the injury and wound can be healed by itself without interfering or injection of over counter pain medication, depending on the size of the opening.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find potential and natural compounds for the treatment of pain and swelling with no side effects, researchers evaluated the effect of bromelain after surgical removal of third molars.
The prospective randomized clinical study included 40 patients requiring surgical removal of impacted mandibular third molars.
After the surgery, according to the tested assays, bromelain showed a significant effect in reducing swelling and pain in 28 out of a total of 40 patients.
Based on the findings, researchers said, "Bromelain can be used as a successful oral enzyme therapy for oral surgery patients, especially after removal of impacted third molars".
In order to reveal more information about bromelain anti-pain and swelling activity the team at the University of Mosul College of Dentistry compared the effect of oral bromelain (4 × 250 mg) versus oral diclofenac sodium (4 × 25 mg) on pain, swelling, trismus, and quality of life (QOL) after surgical removal of impacted lower third molars.
The randomized, double-blind, placebo-controlled study included 45 patients requiring extraction under local anesthesia of a single partial bony impacted mandibular third molar randomly divided into 1 of 3 groups: bromelain, diclofenac, and placebo.
According to the results of the analysis, bromelain and diclofenac groups both showed a significant and similar reduction in pain compared with the placebo group at all intervals.
Both bromelain and diclofenac treatment groups also showed a significant difference in the effect on QOL in most subscales and total scores.
Dr. the lead scientist said, "The results of our study have shown that oral bromelain is an effective therapy to improve the QOL after surgical removal of impacted lower third molars, with an effect on the postoperative sequelae comparable to that of preemptive diclofenac sodium".
Taken altogether, bromelain may be considered supplements for the and treatment of pain and swelling, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars by Singh T1, More V2, Fatima U3, Karpe T4, Aleem MA5, Prameela J. (PubMed)
(2) Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial by Majid OW1, Al-Mashhadani BA. (PubMed)
In the acute of infection, after sensing a wound and injury of the body, the immune first lines of white blood cell defense stimulate the production of blood palette to the infected area with an aim to cover the wound or injury and the inflammatory cytokines to kill off organisms trying to enter the body through the opening.
Please note that overexpression of proinflammatory cytokines in this phase has been found to cause abnormal healing with the formation of scars.
The acute phase of infection arrives and leaves quickly as it is resolved quickly by the body.
However, chronic infection is a result of an immune system that can not kill off all infectious organisms in the acute phase of infection, leading to chronic inflammation that lasts a long time, such as months or years.
Swelling and pain on the joints are one of the most common symptoms in patients with arthritis, particularly in rheumatoid arthritis (RA).
However, some cases of swelling accompanied by symptoms that do not associate to the injury such as fatigue, loss of appetite, and weight gain may be an indication of cancer, heart, liver, or kidney disease.
If you experience some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
Most cases of pain and swelling of the injury and wound can be healed by itself without interfering or injection of over counter pain medication, depending on the size of the opening.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find potential and natural compounds for the treatment of pain and swelling with no side effects, researchers evaluated the effect of bromelain after surgical removal of third molars.
The prospective randomized clinical study included 40 patients requiring surgical removal of impacted mandibular third molars.
After the surgery, according to the tested assays, bromelain showed a significant effect in reducing swelling and pain in 28 out of a total of 40 patients.
Based on the findings, researchers said, "Bromelain can be used as a successful oral enzyme therapy for oral surgery patients, especially after removal of impacted third molars".
In order to reveal more information about bromelain anti-pain and swelling activity the team at the University of Mosul College of Dentistry compared the effect of oral bromelain (4 × 250 mg) versus oral diclofenac sodium (4 × 25 mg) on pain, swelling, trismus, and quality of life (QOL) after surgical removal of impacted lower third molars.
The randomized, double-blind, placebo-controlled study included 45 patients requiring extraction under local anesthesia of a single partial bony impacted mandibular third molar randomly divided into 1 of 3 groups: bromelain, diclofenac, and placebo.
According to the results of the analysis, bromelain and diclofenac groups both showed a significant and similar reduction in pain compared with the placebo group at all intervals.
Both bromelain and diclofenac treatment groups also showed a significant difference in the effect on QOL in most subscales and total scores.
Dr. the lead scientist said, "The results of our study have shown that oral bromelain is an effective therapy to improve the QOL after surgical removal of impacted lower third molars, with an effect on the postoperative sequelae comparable to that of preemptive diclofenac sodium".
Taken altogether, bromelain may be considered supplements for the and treatment of pain and swelling, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars by Singh T1, More V2, Fatima U3, Karpe T4, Aleem MA5, Prameela J. (PubMed)
(2) Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial by Majid OW1, Al-Mashhadani BA. (PubMed)
Bilberry, the Potential Anti Liver Cancer Herbal Remedy, According to PubMed
Scientists may have found a herbal remedy for the treatment of liver cancer with no side effects, according to studies.
Liver cancer is a medical condition characterized by cell growth irregularly in the liver tissue.
The causes of liver cancer are associated with the alternation of cells DNA which normally begin in the cells on the surface of the inner lining.
Liver cancer at the early stage no not cause any symptoms. However, at the advanced stage, liver cancer cells can cause a wide range of symptoms including jaundice, abdominal swelling and pain, and dark urine and white stool accompanied by the general symptoms of cancers such as unintended weight loss, loss of appetite, chronic fatigue and tiredness and gastrointestinal discomforts.
If you experience some symptoms of the above, please make sure you check with your doctor to rule out the possibility of liver cancer.
The most common cause of liver cancer is infected by the hepatitis virus. However, in North America, due to overexpression of overweight and obese of the population, liver cancer may be slowly progressed from nonalcoholic fatty liver disease through cirrhosis to liver cancer.
There is a number of risk factors other than those mentioned above associated with the onset of liver cancer such as male, ethnicity, hepatitis viral carriers.
However, most people with some of the above risk factors have never developed liver cancer.
Some researchers suggested that widespread obesity may be one of the major risk factors involved in the onset of the disease.
Dr. Aleksandrova K, the lead scientist in the article of obesity and liver cancer said, "Obesity and related metabolic disorders have become globally prevalent posing a challenge for the chronically damaged liver and predisposing the development and progression of cancer".
And, "Accumulating evidence has established an association between higher body mass index as an indicator of general obesity and a higher risk of primary liver cancer. The associations are stronger in men, in patients with underlying liver disease and in white ethnic groups. Abdominal obesity, weight gain in adult life and metabolic factors related to visceral fat accumulation were also suggested as important risk factors for liver cancer".
The results clearly suggested that if you are obese, your risk of liver cancer is increased substantially, compared to non-obese individuals.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Scientists on finding a natural ingredient for the treatment of liver cancer investigated the protective effect of bilberry extracts (BBE) and enzymatically modified isoquercitrin (EMIQ) on the hepatocarcinogenic process involving oxidative stress responses.
Rat selected to the study was injected to introduce the two-stage hepatocarcinogenesis in N-diethylnitrosamine-initiated and piperonyl butoxide (PBO).
Co-administration of BBE or EMIQ suppressed these effects with the reductions of GST-P(+) foci (area) to 48.9-49.4% and Ki-67(+) cells proliferation to 55.5-61.4% of the PBO-injected cases. Neither BBE nor EMIQ alone decreased microsomal reactive oxygen species induced by PBO.
Co-administration of BBE and EMIQ decreased the incidences of phospho-PTEN(-) foci which plays a critical role in enhancing malignant proliferation and invasion abilities of liver cancer cells, to 59.8-72.2% and Smad4(-) foci to 62.4-71.5% in the promotion of liver cancer of the PBO-promoted cases.
Furthermore, injection also BBE also suppressed the incidence of phospho-Akt substrate(+) involved liver cancer cell survival to 75.2-75.7% of the PBO-promoted cases.
The finding strongly suggested that co-treatment with BBE or EMIQ suppressed cell proliferation activity of preneoplastic liver cells.
Additionally, in order to reveal more information about bilberry anti-liver cancer activity, researchers examined the anthocyanins cancer chemopreventive properties in preclinical models.
In this study, anthocyanins and their metabolites were analyzed in the urine of two patients with colorectal liver metastases.
A single dose of 1.88 g standardized bilberry extract (mirtoselect) via either nasogastric or nasojejunal tube intra-operatively during liver resection showed that there were more anthocyanins and metabolites in the urine of the patient who received mirtoselect via the stomach than via the jejunum.
These results suggested that bilberry extract (mirtoselect) via nasojejunal tube intra-operatively exerted anti-liver cancer effects without reducing the expression of anthocyanins, as the stomach is the predominant site for anthocyanin absorption.
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of liver cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model by Hara S1, Morita R2, Ogawa T1, Segawa R1, Takimoto N1, Suzuki K3, Hamadate N4, Hayashi SM5, Odachi A6, Ogiwara I6, Shibusawa S7, Yoshida T1, Shibutani M. (PubMed)
(2) Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract by Cai H1, Thomasset SC, P-Berry D, Garcea G, Brown K, Steward WP, Gescher AJ. (PubMed)
(3) Obesity and Liver Cancer by Aleksandrova K1, Stelmach-Mardas M2,3, Schlesinger S. (PubMed)
Liver cancer is a medical condition characterized by cell growth irregularly in the liver tissue.
The causes of liver cancer are associated with the alternation of cells DNA which normally begin in the cells on the surface of the inner lining.
Liver cancer at the early stage no not cause any symptoms. However, at the advanced stage, liver cancer cells can cause a wide range of symptoms including jaundice, abdominal swelling and pain, and dark urine and white stool accompanied by the general symptoms of cancers such as unintended weight loss, loss of appetite, chronic fatigue and tiredness and gastrointestinal discomforts.
If you experience some symptoms of the above, please make sure you check with your doctor to rule out the possibility of liver cancer.
The most common cause of liver cancer is infected by the hepatitis virus. However, in North America, due to overexpression of overweight and obese of the population, liver cancer may be slowly progressed from nonalcoholic fatty liver disease through cirrhosis to liver cancer.
There is a number of risk factors other than those mentioned above associated with the onset of liver cancer such as male, ethnicity, hepatitis viral carriers.
However, most people with some of the above risk factors have never developed liver cancer.
Some researchers suggested that widespread obesity may be one of the major risk factors involved in the onset of the disease.
Dr. Aleksandrova K, the lead scientist in the article of obesity and liver cancer said, "Obesity and related metabolic disorders have become globally prevalent posing a challenge for the chronically damaged liver and predisposing the development and progression of cancer".
And, "Accumulating evidence has established an association between higher body mass index as an indicator of general obesity and a higher risk of primary liver cancer. The associations are stronger in men, in patients with underlying liver disease and in white ethnic groups. Abdominal obesity, weight gain in adult life and metabolic factors related to visceral fat accumulation were also suggested as important risk factors for liver cancer".
The results clearly suggested that if you are obese, your risk of liver cancer is increased substantially, compared to non-obese individuals.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Scientists on finding a natural ingredient for the treatment of liver cancer investigated the protective effect of bilberry extracts (BBE) and enzymatically modified isoquercitrin (EMIQ) on the hepatocarcinogenic process involving oxidative stress responses.
Rat selected to the study was injected to introduce the two-stage hepatocarcinogenesis in N-diethylnitrosamine-initiated and piperonyl butoxide (PBO).
Co-administration of BBE or EMIQ suppressed these effects with the reductions of GST-P(+) foci (area) to 48.9-49.4% and Ki-67(+) cells proliferation to 55.5-61.4% of the PBO-injected cases. Neither BBE nor EMIQ alone decreased microsomal reactive oxygen species induced by PBO.
Co-administration of BBE and EMIQ decreased the incidences of phospho-PTEN(-) foci which plays a critical role in enhancing malignant proliferation and invasion abilities of liver cancer cells, to 59.8-72.2% and Smad4(-) foci to 62.4-71.5% in the promotion of liver cancer of the PBO-promoted cases.
Furthermore, injection also BBE also suppressed the incidence of phospho-Akt substrate(+) involved liver cancer cell survival to 75.2-75.7% of the PBO-promoted cases.
The finding strongly suggested that co-treatment with BBE or EMIQ suppressed cell proliferation activity of preneoplastic liver cells.
Additionally, in order to reveal more information about bilberry anti-liver cancer activity, researchers examined the anthocyanins cancer chemopreventive properties in preclinical models.
In this study, anthocyanins and their metabolites were analyzed in the urine of two patients with colorectal liver metastases.
A single dose of 1.88 g standardized bilberry extract (mirtoselect) via either nasogastric or nasojejunal tube intra-operatively during liver resection showed that there were more anthocyanins and metabolites in the urine of the patient who received mirtoselect via the stomach than via the jejunum.
These results suggested that bilberry extract (mirtoselect) via nasojejunal tube intra-operatively exerted anti-liver cancer effects without reducing the expression of anthocyanins, as the stomach is the predominant site for anthocyanin absorption.
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of liver cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model by Hara S1, Morita R2, Ogawa T1, Segawa R1, Takimoto N1, Suzuki K3, Hamadate N4, Hayashi SM5, Odachi A6, Ogiwara I6, Shibusawa S7, Yoshida T1, Shibutani M. (PubMed)
(2) Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract by Cai H1, Thomasset SC, P-Berry D, Garcea G, Brown K, Steward WP, Gescher AJ. (PubMed)
(3) Obesity and Liver Cancer by Aleksandrova K1, Stelmach-Mardas M2,3, Schlesinger S. (PubMed)
Friday, November 15, 2019
Herbal Arctostaphylos uva-ursi, the Potential and Natural Anti Type 4 Hypersensitivity with No Side Effects, Scientists Find
Scientists may have found a herbal medicine for the prevention and treatment of type 4 hypersensitivity with no side effects, according to studies.
Type 4 allergy or type 4 hypersensitivity is often called delayed-type hypersensitivity as the reaction takes several days to develop.
In other words, instead of happening right the way as that of other types, type 4 hypersensitivity typically develops at least 48 hours after exposure to an antigen.
The process that develops type 4 hypersensitivity involved the activation of the white blood cell cells in stimulating the release of cytokines and chemokines, and macrophages and cytotoxic CD8+ T cells associated with the body's adaptive immune response.
Compared to other types of allergy mediated by the antibody, type 4 allergy is a cell-mediated response.
Type 4 hypersensitivity can induce allergic contact dermatitis, occurred at the site where the antigen contacts the skin, then spread to other regions through contamination of the antigen.
Type 4 hypersensitivity is caused by atopic dermatitis, lung diseases associated with hypersensitivity, type 2 diabetes and inflammation of the thyroid gland.
Treatment of type 4 hypersensitivity is totally depending on the severity of the disease. however, the most appropriate approach is to avoid the offending antigen.
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stones, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the concern of the widespread of Type IV hypersensitivity caused by the contact dermatitis, researchers at the Kinki University examined the combined effect of arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng. (Bearberry leaf) and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis.
Injection of arbutin at a dose of 50 mg/kg 24 h after the application rapidly decreased the swelling of type IV allergic sheep induced edema and adjuvant-induced arthritis by picryl chloride (PC-CD) compared to no reaction at the divided doses of 50 mg/kg.
Arbutin (p.o.) plus indomethacin (s.c.) exerted highly inhibitory effects on the swelling of PC-CD and sheep red cell delayed-type hypersensitivity (SRBC-DTH) compared to that of indomethacin alone.
Furthermore, arbutin (p.o.) and indomethacin (s.c.) in a given portion were simultaneously administered, the inhibitory effect was more potent than that of indomethacin alone in both carrageenin-induced edema and adjuvant-induced arthritis.
The results clearly suggested that arbutin may increase the inhibitory action of indomethacin on PC-CD, SRBC-DTH against type 4 hypersensitivity.
Moreover, in the comparison of water extract (UW-ext) from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf) on the antiallergic and anti-inflammatory activities of dexamethasone ointment, researchers found one or 2% UW-ext ointment did not inhibit the ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema.
However, combined with dexamethasone ointment (0.005 or 0.025%), UW-ext augmented the inhibitory effect of dexamethasone ointment (0.005 or 0.025%) on these allergic and inflammatory models with no side effects.
These findings showed that not all parts of herbal Arctostaphylos uva-ursi processes anti-type 4 allergies, but combined with other therapy all parts augmented the significant anti-allergic and inflammatory activity with no side effects.
Additionally, the investigation of the antitype 4 allergies properties of the combined effect of 50% methanolic extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) and prednisolone also showed similar results as illustrated by the above 2 studies.
U-ext did not show an inhibitory effect on the swelling induced by PC-CD in divided doses of 100mg/kg immediately before and 16 h after the application of PC-CD, while it exhibited a significant therapeutic effect at a dose of 100 mg/kg or more once 24 h after the application.
Injection of the combination of U-ext (p.o.) and prednisolone (s.c.) simultaneously administered, exerted a greater inhibitory effect compared to that of prednisolone alone.
Researchers at the above studies wrote in the final report, "Bearberry leaf possesses a therapeutic effect against immuno-inflammation induced by PC-CD and also increases the inhibitory effect of prednisolone, and its active principle may be arbutin".
Taken altogether, herbal Herbal Arctostaphylos uva-ursi (Bearberry) may be considered a functional remedy for the prevention and combined with primary medicines for the treatment of type 4 hypersensitivity with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. Combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylosuva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)
Type 4 allergy or type 4 hypersensitivity is often called delayed-type hypersensitivity as the reaction takes several days to develop.
In other words, instead of happening right the way as that of other types, type 4 hypersensitivity typically develops at least 48 hours after exposure to an antigen.
The process that develops type 4 hypersensitivity involved the activation of the white blood cell cells in stimulating the release of cytokines and chemokines, and macrophages and cytotoxic CD8+ T cells associated with the body's adaptive immune response.
Compared to other types of allergy mediated by the antibody, type 4 allergy is a cell-mediated response.
Type 4 hypersensitivity can induce allergic contact dermatitis, occurred at the site where the antigen contacts the skin, then spread to other regions through contamination of the antigen.
Type 4 hypersensitivity is caused by atopic dermatitis, lung diseases associated with hypersensitivity, type 2 diabetes and inflammation of the thyroid gland.
Treatment of type 4 hypersensitivity is totally depending on the severity of the disease. however, the most appropriate approach is to avoid the offending antigen.
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stones, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the concern of the widespread of Type IV hypersensitivity caused by the contact dermatitis, researchers at the Kinki University examined the combined effect of arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng. (Bearberry leaf) and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis.
Injection of arbutin at a dose of 50 mg/kg 24 h after the application rapidly decreased the swelling of type IV allergic sheep induced edema and adjuvant-induced arthritis by picryl chloride (PC-CD) compared to no reaction at the divided doses of 50 mg/kg.
Arbutin (p.o.) plus indomethacin (s.c.) exerted highly inhibitory effects on the swelling of PC-CD and sheep red cell delayed-type hypersensitivity (SRBC-DTH) compared to that of indomethacin alone.
Furthermore, arbutin (p.o.) and indomethacin (s.c.) in a given portion were simultaneously administered, the inhibitory effect was more potent than that of indomethacin alone in both carrageenin-induced edema and adjuvant-induced arthritis.
The results clearly suggested that arbutin may increase the inhibitory action of indomethacin on PC-CD, SRBC-DTH against type 4 hypersensitivity.
Moreover, in the comparison of water extract (UW-ext) from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf) on the antiallergic and anti-inflammatory activities of dexamethasone ointment, researchers found one or 2% UW-ext ointment did not inhibit the ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema.
However, combined with dexamethasone ointment (0.005 or 0.025%), UW-ext augmented the inhibitory effect of dexamethasone ointment (0.005 or 0.025%) on these allergic and inflammatory models with no side effects.
These findings showed that not all parts of herbal Arctostaphylos uva-ursi processes anti-type 4 allergies, but combined with other therapy all parts augmented the significant anti-allergic and inflammatory activity with no side effects.
Additionally, the investigation of the antitype 4 allergies properties of the combined effect of 50% methanolic extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) and prednisolone also showed similar results as illustrated by the above 2 studies.
U-ext did not show an inhibitory effect on the swelling induced by PC-CD in divided doses of 100mg/kg immediately before and 16 h after the application of PC-CD, while it exhibited a significant therapeutic effect at a dose of 100 mg/kg or more once 24 h after the application.
Injection of the combination of U-ext (p.o.) and prednisolone (s.c.) simultaneously administered, exerted a greater inhibitory effect compared to that of prednisolone alone.
Researchers at the above studies wrote in the final report, "Bearberry leaf possesses a therapeutic effect against immuno-inflammation induced by PC-CD and also increases the inhibitory effect of prednisolone, and its active principle may be arbutin".
Taken altogether, herbal Herbal Arctostaphylos uva-ursi (Bearberry) may be considered a functional remedy for the prevention and combined with primary medicines for the treatment of type 4 hypersensitivity with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. Combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylosuva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)
Healthy Food Onion Reduces The Risk of Esophageal cancer
An esophagus or gullet, an organ in vertebrates, is the tube that leads foods from the pharynx to the stomach.
Esophageal cancer is a medical condition caused by cell growth disorderly and uncontrollably in the tissue of the esophagus due to the alternation of the cell DNA.
More precisely, esophageal cancer can be a result of DNA alternation of the cells that line the upper part of the esophagus or glandular cells that line the lower part of the esophagus, connecting to the stomach.
Patients with esophageal cancer at the very early stage due to the very small size of the tumor are asymptomatic. However, at the advanced stage, esophageal cancer tends to travel a distance away to infect other healthy tissue and organ, leading to secondary metastasis.
Most common areas of metastasis of esophageal cancer are lymph node around the bottom of the esophagus, stomach and chest.
According to the statistic, esophageal cancer is the seventh most common cause of cancer death among men. In 2019, about 17,650 new esophageal cancer cases will bed diagnosed, including 13,750 men and 3,900 women.
Esophageal cancer will cause the death of 16,080 Americans, including 13,020 men and 3,060 women.
Believe it or not, esophageal cancer is more common among men than among women. The lifetime risk of esophageal cancer in the US is 1 in 132 in men and about 1 in 455 in women.
Esophageal cancer can be classified into, depending on the location which cancer starts
* Squamous cancer
If the cancer cell starts in the upper part of the esophagus caused by the DNA alternation of the squamous cell.
* Adenocarcinomas
If the cancer cell starts in the lower part of the esophagus caused by the DNA and alternation of the glandular cells.
Most common symptoms of esophageal cancer are difficulty swallowing or pain caused by refluxing or swallowing, pain in the throat or back, behind the breastbone, heartburn, hoarseness or coughing, coughing blood and accompanied by the general symptoms shared by other types of cancer.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a potential compound for the treatment of esophageal cancer, researchers examined the effect of raw garlic/onion consumed at least one time per week on the development of squamous cell carcinoma (SCC) in three different sections of the esophagus.
The study included a total of A 343 patients with SCC of the esophagus and 755 cancer-free control subjects recruited for this study from 1996 to 2005.
According to the results of tested assays, intake of raw onions/garlic, and fruits are significantly protective against esophageal SSC risk compared to the increased risk of hot foods.
In other words, adding additional certain dietary components may affect carcinogenesis locally and systemically.
Furthermore, according to the study of the Istituto di Ricerche Farmacologiche "Mario Negri",
consumption of onions showed a protective effect on esophageal cancer, compared to garlic and other vegetables.
More precisely, onion and garlic intake improved the relative risk ratio by 0.12 and 0.43, respectively.
The results strongly suggested the inverse association between the frequency of use of allium vegetables such as onion and garlic against the risk of several common cancers, including esophageal cancer
Dr. Galeone C wrote in the final report, "Allium vegetables are a favorable correlate of cancer risk in Europe".
Taken altogether, onion may be considered a remedy for the prevention and treatment of adjuvant esophageal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Cancer of Esophagus/Esophageal cancer by Kyle J. Norton
Antioxidant Lycopene Protects the Lung Against Pulmonary Fibrosis (PF)
Pulmonary diseases are a class of conditions associated with the lungs, including asthma, COPD, influenza, pneumonia and tuberculosis, and lung cancer.
In other words, any diseases involved in breathing problems that reduce the function of the lung are pulmonary diseases.
The lung formed part of the respiratory system with a function of the primary organs of the respiratory system to absorb oxygen to the blood and shall carbon dioxide from the blood.
Pulmonary fibrosis (PF) is a condition associated with the formation of scars in the lungs. Over time, overexpression of scar tissue can destroy lung and interfere with the lung to take oxygen to the blood.
According to the American Lung Association, the most common PF is idiopathic pulmonary fibrosis. Approximately 50,000 new cases of IPF are diagnosed each year.
The most common symptoms of PF are shortness of breath, dry, and hacking cough, fast, and shallow breathing, tiredness, aching joints, and muscles and clubbing of the tips of the fingers or toes.
If you have experienced some of the aforementioned symptoms that do not heal in a short time, please check with your doctor to rule out the possibility.
Most cases of IPF are found in patients between the ages of 50 and 70 years old, particularly in men.
Dr. Selman M, the lead scientist in the joint study led by the Universidad Nacional Autónoma de México wrote, "Idiopathic pulmonary fibrosis is a chronic, progressive, and usually fatal lung disorder of unknown etiology. The disease likely results from the interaction of genetic susceptibility architecture, environmental factors such as smoking, and an abnormal epigenetic reprogramming that leads to complex pathogenesis".
And, "Idiopathic pulmonary fibrosis occurs in middle-aged and mainly elderly adults, and in this context, age has emerged as its strongest risk factor. However, the mechanisms linking it to aging are uncertain".
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of lung disease researchers examined the effects of lycopene extracted from tomatoes on pulmonary fibrosis PF induced by bleomycin BLM in rats.
The study included 60 Sprague-Dawley rats randomly divided into 3 groups of 20 rats each for a normal control group (group C), BLM-treated group (group M), and lycopene + BLM-treated group (group L).
More precisely, group L received lycopene diluted with olive oil at a dose of 5 mg/kg body weight once a day after BLM instillation, and groups C and M received the same amounts of olive oil.
Based on the tested analysis, group L showed a significantly reduced lung coefficient (day 14, P < .01) as well as the extents of alveolitis (day 7 and 14, P < .05) and pulmonary fibrosis PF (day 14 and 28, P < .05) compared to control.
The concentration of pro-inflammatory cytokines and oxidative stress markers in the lung also a significant decrease in the lycopene treatment group compared to control.
Based on the findings, researchers said, "lycopene can partially reduce the extent of PF induced by BLM in rats. These findings suggest that the suppression of oxidative stress, the reduction of plasma TNF-alpha and NO levels, and the down-regulation of TNF-alpha in lungs contribute to the alleviation of PF in rats administered lycopene".
Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of pulmonary fibrosis, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene from tomatoes partially alleviates the bleomycin-induced experimental pulmonary fibrosis in rats by Zhou C1, Han W, Zhang P, Cai M, Wei D, Zhang C. (PubMed)
(2) Aging and Pulmonary Fibrosis by Selman M1, Buendía-Roldán I1, Pardo A. (PubMed)
In other words, any diseases involved in breathing problems that reduce the function of the lung are pulmonary diseases.
The lung formed part of the respiratory system with a function of the primary organs of the respiratory system to absorb oxygen to the blood and shall carbon dioxide from the blood.
Pulmonary fibrosis (PF) is a condition associated with the formation of scars in the lungs. Over time, overexpression of scar tissue can destroy lung and interfere with the lung to take oxygen to the blood.
According to the American Lung Association, the most common PF is idiopathic pulmonary fibrosis. Approximately 50,000 new cases of IPF are diagnosed each year.
The most common symptoms of PF are shortness of breath, dry, and hacking cough, fast, and shallow breathing, tiredness, aching joints, and muscles and clubbing of the tips of the fingers or toes.
If you have experienced some of the aforementioned symptoms that do not heal in a short time, please check with your doctor to rule out the possibility.
Most cases of IPF are found in patients between the ages of 50 and 70 years old, particularly in men.
Dr. Selman M, the lead scientist in the joint study led by the Universidad Nacional Autónoma de México wrote, "Idiopathic pulmonary fibrosis is a chronic, progressive, and usually fatal lung disorder of unknown etiology. The disease likely results from the interaction of genetic susceptibility architecture, environmental factors such as smoking, and an abnormal epigenetic reprogramming that leads to complex pathogenesis".
And, "Idiopathic pulmonary fibrosis occurs in middle-aged and mainly elderly adults, and in this context, age has emerged as its strongest risk factor. However, the mechanisms linking it to aging are uncertain".
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of lung disease researchers examined the effects of lycopene extracted from tomatoes on pulmonary fibrosis PF induced by bleomycin BLM in rats.
The study included 60 Sprague-Dawley rats randomly divided into 3 groups of 20 rats each for a normal control group (group C), BLM-treated group (group M), and lycopene + BLM-treated group (group L).
More precisely, group L received lycopene diluted with olive oil at a dose of 5 mg/kg body weight once a day after BLM instillation, and groups C and M received the same amounts of olive oil.
Based on the tested analysis, group L showed a significantly reduced lung coefficient (day 14, P < .01) as well as the extents of alveolitis (day 7 and 14, P < .05) and pulmonary fibrosis PF (day 14 and 28, P < .05) compared to control.
The concentration of pro-inflammatory cytokines and oxidative stress markers in the lung also a significant decrease in the lycopene treatment group compared to control.
Based on the findings, researchers said, "lycopene can partially reduce the extent of PF induced by BLM in rats. These findings suggest that the suppression of oxidative stress, the reduction of plasma TNF-alpha and NO levels, and the down-regulation of TNF-alpha in lungs contribute to the alleviation of PF in rats administered lycopene".
Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of pulmonary fibrosis, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene from tomatoes partially alleviates the bleomycin-induced experimental pulmonary fibrosis in rats by Zhou C1, Han W, Zhang P, Cai M, Wei D, Zhang C. (PubMed)
(2) Aging and Pulmonary Fibrosis by Selman M1, Buendía-Roldán I1, Pardo A. (PubMed)
Herbal Ashwagandha Inhibits the Onset of Breast Cancer Patients
The breast formed part of the reproductive system consists of tissue overlying the chest (pectoral) muscles. In women, the breasts are made of produces milk (glandular tissue) and fatty tissue.
The size of the women's breast is totally depending on the amount of breast fatty tissue.
Depending on the menstrual stage induced by hormone expression, the breast ducts transport milk from the lobules out to the nipple.
In pregnancy, the changes to the breasts can start as early as 1 to 2 weeks after conception, leading to swelling or tenderness.
Breast cancer is a medical condition caused by the alternation of DNA of cells in the breast tissue.
According to the statistic, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Most cases of breast cancer start with cell growth disorderly on the surface of the inner lining of the breast tissue. At the later stage, malignant cells can infected other healthy cells and tissue far the way from the breast through fluids and blood circulation.
The exact causes of breast cancer are unknown. However, aging, reproductive history, dense breast, family and personal breast cancer history, particularly in women with the genetic preposition of BRCA 1 and 2 are some of the most prevalent factors associated with the disease.
Women inherited the mutated gene BRCA 1 and 2 are associated with over 60% of breast cancer risk compared to women who do not.
Some researchers suggested the promotion of a high-fat diet-induced overweight and obesity over the past few decades may correlate to the increased incidence and motility of breast cancer in the US.
Dr. Carroll KK wrote, "High-fat diets are thought to increase the risk of breast cancer because animals develop mammary cancer more readily when they are fed high-fat compared to low-fat diets, and breast cancer incidence and mortality are higher in countries with high-fat as compared to those with low-fat diets".
And, "Studies on migrants have shown that breast cancer incidence and mortality increase in populations who move from countries with low-fat to those with high-fat diets, indicating that observed geographical differences in breast cancer are due to environmental rather than genetic factors".
These results strongly suggested the long-term high fat diet is associated with the increased risk of breast cancer.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
With an aim to find a potent compound for the treatment of symptoms associated the chemotherapy in breast cancer patients, researchers examined the Withania somnifera (Ashwagandha) anti side effects of chemo drug.
The open-label prospective nonrandomized comparative trial included a total of on 100 patients with breast cancer in all stages undergoing either a combination of chemotherapy with oral Withania somnifera at a dose of 2 g every 8 hours or chemotherapy alone.
Withania somnifera root extract was administered to patients in the study group throughout the course of chemotherapy.
According to the results, patients in the control arm or chemotherapy only treatment group experienced a statistically significant higher estimated marginal means of fatigue score compared to the study group.
Statistically, 7 out of 18 symptoms in the intervention group was significantly elevated in the control compared with the control group, according to the various symptom scales of the EORTC QLQ-C30.
More importantly, the 24-month overall survival for all stages in the study group was significantly higher at 72% compared to 56% of the control.
However, a median follow-up duration of 26 months.was not different in both groups. In other words, continued Withania somnifera root extract treatment may increase the survival rate of breast cancer patients in all stages.
Based on the findings, researchers said, "Withania somnifera has potential against cancer-related fatigue, in addition to improving the quality of life".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for reduction of chemo drugs side effects in breast cancer patients, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients by Biswal BM1, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. (PubMed)
(2) An anti-cancerous protein fraction from Withania somnifera induces ROS-dependent mitochondria-mediated apoptosis in human MDA-MB-231 breast cancer cells by Dar PA1, Mir SA2, Bhat JA2, Hamid A3, Singh LR4, Malik F5, Dar TA. (PubMed)
(3) Dietary fat and breast cancer by Carroll KK. (PubMed)
The size of the women's breast is totally depending on the amount of breast fatty tissue.
Depending on the menstrual stage induced by hormone expression, the breast ducts transport milk from the lobules out to the nipple.
In pregnancy, the changes to the breasts can start as early as 1 to 2 weeks after conception, leading to swelling or tenderness.
Breast cancer is a medical condition caused by the alternation of DNA of cells in the breast tissue.
According to the statistic, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Most cases of breast cancer start with cell growth disorderly on the surface of the inner lining of the breast tissue. At the later stage, malignant cells can infected other healthy cells and tissue far the way from the breast through fluids and blood circulation.
The exact causes of breast cancer are unknown. However, aging, reproductive history, dense breast, family and personal breast cancer history, particularly in women with the genetic preposition of BRCA 1 and 2 are some of the most prevalent factors associated with the disease.
Women inherited the mutated gene BRCA 1 and 2 are associated with over 60% of breast cancer risk compared to women who do not.
Some researchers suggested the promotion of a high-fat diet-induced overweight and obesity over the past few decades may correlate to the increased incidence and motility of breast cancer in the US.
Dr. Carroll KK wrote, "High-fat diets are thought to increase the risk of breast cancer because animals develop mammary cancer more readily when they are fed high-fat compared to low-fat diets, and breast cancer incidence and mortality are higher in countries with high-fat as compared to those with low-fat diets".
And, "Studies on migrants have shown that breast cancer incidence and mortality increase in populations who move from countries with low-fat to those with high-fat diets, indicating that observed geographical differences in breast cancer are due to environmental rather than genetic factors".
These results strongly suggested the long-term high fat diet is associated with the increased risk of breast cancer.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
With an aim to find a potent compound for the treatment of symptoms associated the chemotherapy in breast cancer patients, researchers examined the Withania somnifera (Ashwagandha) anti side effects of chemo drug.
The open-label prospective nonrandomized comparative trial included a total of on 100 patients with breast cancer in all stages undergoing either a combination of chemotherapy with oral Withania somnifera at a dose of 2 g every 8 hours or chemotherapy alone.
Withania somnifera root extract was administered to patients in the study group throughout the course of chemotherapy.
According to the results, patients in the control arm or chemotherapy only treatment group experienced a statistically significant higher estimated marginal means of fatigue score compared to the study group.
Statistically, 7 out of 18 symptoms in the intervention group was significantly elevated in the control compared with the control group, according to the various symptom scales of the EORTC QLQ-C30.
More importantly, the 24-month overall survival for all stages in the study group was significantly higher at 72% compared to 56% of the control.
However, a median follow-up duration of 26 months.was not different in both groups. In other words, continued Withania somnifera root extract treatment may increase the survival rate of breast cancer patients in all stages.
Based on the findings, researchers said, "Withania somnifera has potential against cancer-related fatigue, in addition to improving the quality of life".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for reduction of chemo drugs side effects in breast cancer patients, pending to the result of larger sample size and multicenter study
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients by Biswal BM1, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. (PubMed)
(2) An anti-cancerous protein fraction from Withania somnifera induces ROS-dependent mitochondria-mediated apoptosis in human MDA-MB-231 breast cancer cells by Dar PA1, Mir SA2, Bhat JA2, Hamid A3, Singh LR4, Malik F5, Dar TA. (PubMed)
(3) Dietary fat and breast cancer by Carroll KK. (PubMed)
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