Herbal Burdock may process a profound and positive effect in inhibited free radicals activity in the induction of early onset of natural aging, some scientists suggested.
Burdock is planted in the group of biennial thistles, genus Arctium, belongings to the family Asteraceae, native to the Euro.
The herb has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
A free radical is any atom or molecule that has a single unpaired electron in an outer shell and highly reactive to react with another cell, which in turn, causes oxidative damage to the enzymes, other protein,.... unsaturated fatty acid.
Prolonged overexpression of free radical was found to cause widespread damage through domino's chain reaction auto-catalytically after attacking the lipid bilayers of the cell walls.
Truly, epidemiological studies strongly suggested that reactive oxygen and nitrogen species (ROS/RNS) existed as radicals or nonradicals, as well as reactive sulfur species and reactive carbon species, play a major role in aging processes.
Dr. Wölfle U, the lead scientist in the examine the effect of ROS in the induction of skin aging said, " When RMS concentrations exceed a certain threshold, cell compartments and cells are injured and destroyed" and " Endogenous physiological mechanisms are able to neutralize RMS to some extent, thereby limiting damage. In the skin, however, pollutants and particularly UV irradiation are able to produce additional oxidants which overload the endogenous protection system and cause early aging, debilitation of immune functions, and skin cancer".
Some researchers suggested that an unhealthy diet with low nutrition high in advanced glycation end products (AGEs) may also contribute to oxidation induced early aging process.
In the study of the activity of superoxide dismutase (SOD) and the content of Malondialdehyde (MDA) and lipofuscin in the tissues of the liver, brain and blood serum of the lab rats at the 30 days after feeding with the Niubanggen decoction, researchers found that* Levels of SOD in the liver tissue and blood serum were improved substantially in decoction treat rats
* Levels of the content of MDA in the brain tissue and blood serum were lower in compared to baseline.
* Levels of lipofuscin were also dropped significantly.
These results suggested that herbal burdock exerts strong anti-aging effects through activating antioxidant of the host in inhibited ROS in induction oxidative stress through the expression of biomarkers of SOD and MDA and lipofuscin.
Herbal burdock antioxidant activity in the differentiation of 23 distinct herbal medicine was found to process anti-elastase activities up to 51% in the prevention of the destruction of elastic fiber.
Furthermore, in the review of the therapeutic effects of the active compounds presented in the different botanical parts of burdock, researchers at the The Hong Kong Polytechnic University, found that the root of burdock containing active ingredients "detoxify" blood in terms of TCM and promote blood circulation to the skin surface, improving the skin quality/texture and curing skin diseases like eczema.
However, burdock may induce contact dermatitis and other allergic/inflammatory responses, the University continued.
Taking all together, function herb burdock processes bioactive ingredients that protect the skin against aging and disease through its antioxidants activity in inhibiting the overexpression of free radicals.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
References
1. An experimental research into the anti-aging effects of Radix Arctii Lappae, by Liu S, Li Y, Li S, Luo M, Liu X.(PubMed)
2. Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants.
Thring TS, Hili P, Naughton DP.(PubMed)
4. A review of the pharmacological effects of Arctium lappa (burdock)" by Chan YS, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, Leung GP, Yu PH, Chan SW., (PubMed)
(5) Sugar Sag: Glycation and the Role of Diet in Aging Skin by Nguyen HP1, Katta R(PubMed)
Friday, November 22, 2019
Thursday, November 21, 2019
Herbal Andrographis The Natural and Potential Anti Oral Cancer Functional Plant
Scientists may have found a bioactive compound for the prevention and treatment of oral cancer with no side effects, according to studies.
Oral cancer is any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).
Most cases of oral cancer start in the cells on the surface of the inner lining of the oral cavity.
At stage 0 and 1, patients may not experience any symptoms as the cancer is localized in the outermost layer of tissue in the oral cavity or oropharynx less than 2 cm across.
However, as the cancer proliferation, at the advanced stage, the cancerous cells may travel a distance away from the oral cavity to infect other healthy tissue or organs, leading to secondary metastasis.
The liver, lungs, lymph nodes, and bones are common areas of oral cancer metastasis.
According to the statistic provided by the American Cancer Society, in the US, every year, approximately 51,000 people will get oral cavity or oropharyngeal cancer causing the death of 10,000 patients.
Depending on the stage of cancer, the 5 years survival rate of early stages (1 and 0) is 84% and 64% if cancer has spread to surrounding tissues or organs and/or the regional lymph nodes.
Men, age, exposure to the Ultraviolet light, genetic preposition, tobacco use, alcohol and chew betel quid are the risk factors associated with the early onset of oral cancer.
Some researchers suggested that infected by the Human papillomaviruses is the most common cause of oropharyngeal cancers in the Western world found in 25 percent of patients.
The cases controlled study consisted of newly diagnosed patients with squamous cell carcinoma of the oral cavity and oropharynx.conducted by the McGill University in examining the association between human papillomavirus (HPV) infection and risk of developing oral cancer showed that
* HPV DNA was detected in 19% of cases (14 out of 72), and 5% of controls (six out of 129).
* Among tonsil-related cancers (palatine tonsil and base of tongue) viral DNA was detected in 43% of cases (nine out of 21).
* The OR for tonsil-related cancers for high-risk HPV types was 19.32.
The findings clearly provide evidence supporting a strong causal association between HPV infection and tonsil-related cancers.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.
The medical plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients of herbal Andrographis include diterpene lactones, neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.
On finding a natural ingredient for the treatment of oral cancer with no side effects, researchers examined the effects of Andrographolide (Andro) isolated from an herbal plant, Andrographis paniculata.
Injection of Andro potently suppressed squamous cell carcinogenesis induced by 7,12-dimethyl-1,2-benzanthracene (DMBA) in the hamster model of cheek buccal pouch.
Andro reduced the genes associated with the activation of a protein (The nuclear factor NF-κB) that promotes cell proliferation and prevents cell apoptosis.
Furthermore, Andro suppressed transcription factors that attenuate neoplastic cell proliferation, promoted cancerous cell apoptosis, and mitigated tumor-induced angiogenesis.
Moreover, Andro retarded growth decreased proliferation, and promoted apoptosis of Tb cells, a human tongue squamous cell carcinoma cell line, in time- and dose-dependent manners.
Dr. Wang LJ, the lead scientist wrote, "Our results thus demonstrate that NF-κB activation plays important roles in the pathogenesis of chemically induced squamous cell carcinoma". and By inhibition of aberrant NF-κB activation, Andro treats chemically induced oral squamous cell carcinogenesis".
In-depth analysis, Andro reduced the production of cytokines, chemokines and the nuclear factor (NF)-κB signaling pathway that involves the initiation of cancer cells.
And, Andro inhibited cancer growth progression through a series of mechanisms, including inhibition of proteins that involved in cell growth, survival, development, and differentiation (such as Janus tyrosine kinases-signal transducers and activators of transcription, phosphatidylinositol 3-kinase and NF-κB signalling pathways) and cell division through activation of genes (p53 and p21) that are associated with tumor suppression.
These results clearly suggested Andro processes a strong effect in the inhibition of cancer cell proliferation, survival, metastasis, and angiogenesis.
Taken altogether, herbal Andrographis processed a bioactive compound Andro may be considered a functional herb for the prevention and combined with primary therapy for the treatment of oral cancer with no side effects, pending to the confirmation of large sample size and multicenter human study.
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Andrographolide inhibits oral squamous cell carcinogenesis through NF-κB inactivation by Wang LJ, Zhou X, Wang W, Tang F, Qi CL, Yang X, Wu S, Lin YQ, Wang JT, Geng JG. (PubMed)
(2) Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. by Lim JC, Chan TK, Ng DS, Sagineedu SR, Stanslas J, Wong WS(PubMed)
(3) Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada by Pintos J1, Black MJ, Sadeghi N, Ghadirian P, Zeitouni AG, Viscidi RP, Herrero R, Coutlée F, Franco EL. (PubMed)
Oral cancer is any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).
Most cases of oral cancer start in the cells on the surface of the inner lining of the oral cavity.
At stage 0 and 1, patients may not experience any symptoms as the cancer is localized in the outermost layer of tissue in the oral cavity or oropharynx less than 2 cm across.
However, as the cancer proliferation, at the advanced stage, the cancerous cells may travel a distance away from the oral cavity to infect other healthy tissue or organs, leading to secondary metastasis.
The liver, lungs, lymph nodes, and bones are common areas of oral cancer metastasis.
According to the statistic provided by the American Cancer Society, in the US, every year, approximately 51,000 people will get oral cavity or oropharyngeal cancer causing the death of 10,000 patients.
Depending on the stage of cancer, the 5 years survival rate of early stages (1 and 0) is 84% and 64% if cancer has spread to surrounding tissues or organs and/or the regional lymph nodes.
Men, age, exposure to the Ultraviolet light, genetic preposition, tobacco use, alcohol and chew betel quid are the risk factors associated with the early onset of oral cancer.
Some researchers suggested that infected by the Human papillomaviruses is the most common cause of oropharyngeal cancers in the Western world found in 25 percent of patients.
The cases controlled study consisted of newly diagnosed patients with squamous cell carcinoma of the oral cavity and oropharynx.conducted by the McGill University in examining the association between human papillomavirus (HPV) infection and risk of developing oral cancer showed that
* HPV DNA was detected in 19% of cases (14 out of 72), and 5% of controls (six out of 129).
* Among tonsil-related cancers (palatine tonsil and base of tongue) viral DNA was detected in 43% of cases (nine out of 21).
* The OR for tonsil-related cancers for high-risk HPV types was 19.32.
The findings clearly provide evidence supporting a strong causal association between HPV infection and tonsil-related cancers.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.
The medical plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients of herbal Andrographis include diterpene lactones, neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.
On finding a natural ingredient for the treatment of oral cancer with no side effects, researchers examined the effects of Andrographolide (Andro) isolated from an herbal plant, Andrographis paniculata.
Injection of Andro potently suppressed squamous cell carcinogenesis induced by 7,12-dimethyl-1,2-benzanthracene (DMBA) in the hamster model of cheek buccal pouch.
Andro reduced the genes associated with the activation of a protein (The nuclear factor NF-κB) that promotes cell proliferation and prevents cell apoptosis.
Furthermore, Andro suppressed transcription factors that attenuate neoplastic cell proliferation, promoted cancerous cell apoptosis, and mitigated tumor-induced angiogenesis.
Moreover, Andro retarded growth decreased proliferation, and promoted apoptosis of Tb cells, a human tongue squamous cell carcinoma cell line, in time- and dose-dependent manners.
Dr. Wang LJ, the lead scientist wrote, "Our results thus demonstrate that NF-κB activation plays important roles in the pathogenesis of chemically induced squamous cell carcinoma". and By inhibition of aberrant NF-κB activation, Andro treats chemically induced oral squamous cell carcinogenesis".
In-depth analysis, Andro reduced the production of cytokines, chemokines and the nuclear factor (NF)-κB signaling pathway that involves the initiation of cancer cells.
And, Andro inhibited cancer growth progression through a series of mechanisms, including inhibition of proteins that involved in cell growth, survival, development, and differentiation (such as Janus tyrosine kinases-signal transducers and activators of transcription, phosphatidylinositol 3-kinase and NF-κB signalling pathways) and cell division through activation of genes (p53 and p21) that are associated with tumor suppression.
These results clearly suggested Andro processes a strong effect in the inhibition of cancer cell proliferation, survival, metastasis, and angiogenesis.
Taken altogether, herbal Andrographis processed a bioactive compound Andro may be considered a functional herb for the prevention and combined with primary therapy for the treatment of oral cancer with no side effects, pending to the confirmation of large sample size and multicenter human study.
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Andrographolide inhibits oral squamous cell carcinogenesis through NF-κB inactivation by Wang LJ, Zhou X, Wang W, Tang F, Qi CL, Yang X, Wu S, Lin YQ, Wang JT, Geng JG. (PubMed)
(2) Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. by Lim JC, Chan TK, Ng DS, Sagineedu SR, Stanslas J, Wong WS(PubMed)
(3) Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada by Pintos J1, Black MJ, Sadeghi N, Ghadirian P, Zeitouni AG, Viscidi RP, Herrero R, Coutlée F, Franco EL. (PubMed)
Herbal Aloe Vera, the Potent Anti Colon Cancer Herbal Remedy
Herbal Aloe vera may have a profound and positive effect on reducing the risk and treatment of colon cancer, with no side effects, some scientists suggested.
Colon Cancer is a condition characterized by the abnormal proliferation of cells in the colon.
Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. In the early, as the cancer cells are only found in the outmost layer of the localized linning, patients may not experience any symptoms.
However, in the advanced stage, the colon cancer cells can travel a distance away to infect other healthy tissue or organs, leading to secondary metastasis.
The most common sites of metastasis for colon or rectal cancer is the liver and lung.
According to the statistic provided by the American Cancer Society, colorectal cancer is the third most common cancer diagnosed in the United States. Every year approximately, 90000 new cases of colon cancer. 43,000 new cases of rectal cancer are diagnosed, leading to the death of 50,000 patients.
The lifetime risk of developing colorectal cancer is about 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
The 5-year survival rate for patients diagnosed with localized stage colorectal cancer is 90%. About 39% of patients are diagnosed at this early stage.
Although there are many risk factors associated with the onset of colon cancer such as age, family and personal history, genetic preposition, smoking, alcohol, being overweight or obese are, many researchers suggested that the most common cause of colon cancer in the Western world is due to the promotion of the Western diet.
Dr. Jessie A. Satia, the lead scientist in the examine the dietary patterns and colon cancer risk in Whites and African Americans in North Carolina strongly indicated "Compared to the Western-Southern pattern, the fruit-vegetable and metropolitan patterns were associated with more healthful dietary behaviors (e.g., higher vegetable intake and lower red meat consumption), and demographic/lifestyle characteristics typically correlated with low colon cancer risk, for example, lower BMI, higher education, and higher NSAID use".
And, "The fruit-vegetable pattern was significantly inversely associated with colon cancer risk in Whites (OR = 0.4, 95% CI = 0.3–0.6) and the metropolitan pattern with a nonsignificant 30% risk reduction in both Whites and African Americans after adjustment for education".
These results strongly suggested that people who follow the diet pattern of the Western diet are at substantial risk of the disease. In other words, the risk of colon cancer is significantly reduced for people who follow the diet with high fruits and vegetables and low red meat and processed foods.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.
The medical plant has been used in herbal medicine in treating many kinds of diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.
The main areas of chemical constituents of Aloe vera include Aloe-Emodin, amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharides, polysaccharides, salicylic acid, saponins, and sterols.
With an aim to find a natural ingredient or remedy for the treatment of colon cancer, researchers at the Sree Chitra Tirunal Institute for Medical Sciences and Technology examine the anti-colon cancer effects on Aloe-emodin (AE), a natural anthraquinone.
In colon cancer cell lines, AE inhibited cell proliferation by the cell cycle arrest at the G2/M phase and protein associated with cellular proliferation and division.
AE also induced cancer cell death by stimulating the function of proteins associated with pro-apoptosis.
In order to obtain additional information related to the Aloe vera anti-colon cancer activity, researchers analyzed the molecular mechanisms involved in the anti-migratory and antiangiogenic activity of this hydroxy anthraquinone.
AE suppressed the phorbol-12-myristyl-13-acetate (PMA), a diester of phorbol in the promotion of promotes tumor expression through migration and invasion.
AE also inhibited the mRNA expression of colon cancer cells and the matrixes involved malignant tumor growth, invasion, and metastasis and gene associated with the signaling in the formation and dissemination of a range of cancers.
Furthermore, EA inhibited the Vascular Endothelial Growth Factor (VEGF) expression in forming a new blood vessel in the promotion of endothelial cell migration/invasion.
Moreover, AE also suppressed the protein complex that controls the transcription of DNA, cytokine production and cell survival.
Researchers wrote in the summary of the experiment, "These data indicate that AE target multiple molecules responsible for cellular invasion, migration and angiogenesis" and Inhibitory effect on angiogenic and metastatic regulatory processes make AE a sensible candidate as a specific blocker of tumor-associated events".
Taken altogether, herbal Aloe vera processed a major bioactive compound Aloe-emodin may be considered a functional remedy for the prevention and combined with conventional medicine for the treatment of colon cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Aloe emodin induces G2/M cell cycle arrest and apoptosis via activation of caspase-6 in human colon cancer cells by Suboj P, Babykutty S, Srinivas P, Gopala S.(PubMed)
(2) Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB by Suboj P, Babykutty S, Valiyaparambil Gopi DR, Nair RS, Srinivas P, Gopala S.(PubMed)
(3) Dietary Patterns and Colon Cancer Risk in Whites and African Americans in the North Carolina Colon Cancer Study by Jessie A. Satia, Marilyn Tseng, Joseph A. Galanko, Christopher Martin, and Robert S. Sandler. (PMC)
(4) Western diet increases colorectal cancer risk in Japanese women: Cohort study by 25-Jul-2017 By Gary Scattergood. (NUTRA)
Colon Cancer is a condition characterized by the abnormal proliferation of cells in the colon.
Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. In the early, as the cancer cells are only found in the outmost layer of the localized linning, patients may not experience any symptoms.
However, in the advanced stage, the colon cancer cells can travel a distance away to infect other healthy tissue or organs, leading to secondary metastasis.
The most common sites of metastasis for colon or rectal cancer is the liver and lung.
According to the statistic provided by the American Cancer Society, colorectal cancer is the third most common cancer diagnosed in the United States. Every year approximately, 90000 new cases of colon cancer. 43,000 new cases of rectal cancer are diagnosed, leading to the death of 50,000 patients.
The lifetime risk of developing colorectal cancer is about 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
The 5-year survival rate for patients diagnosed with localized stage colorectal cancer is 90%. About 39% of patients are diagnosed at this early stage.
Although there are many risk factors associated with the onset of colon cancer such as age, family and personal history, genetic preposition, smoking, alcohol, being overweight or obese are, many researchers suggested that the most common cause of colon cancer in the Western world is due to the promotion of the Western diet.
Dr. Jessie A. Satia, the lead scientist in the examine the dietary patterns and colon cancer risk in Whites and African Americans in North Carolina strongly indicated "Compared to the Western-Southern pattern, the fruit-vegetable and metropolitan patterns were associated with more healthful dietary behaviors (e.g., higher vegetable intake and lower red meat consumption), and demographic/lifestyle characteristics typically correlated with low colon cancer risk, for example, lower BMI, higher education, and higher NSAID use".
And, "The fruit-vegetable pattern was significantly inversely associated with colon cancer risk in Whites (OR = 0.4, 95% CI = 0.3–0.6) and the metropolitan pattern with a nonsignificant 30% risk reduction in both Whites and African Americans after adjustment for education".
These results strongly suggested that people who follow the diet pattern of the Western diet are at substantial risk of the disease. In other words, the risk of colon cancer is significantly reduced for people who follow the diet with high fruits and vegetables and low red meat and processed foods.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.
The medical plant has been used in herbal medicine in treating many kinds of diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.
The main areas of chemical constituents of Aloe vera include Aloe-Emodin, amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharides, polysaccharides, salicylic acid, saponins, and sterols.
With an aim to find a natural ingredient or remedy for the treatment of colon cancer, researchers at the Sree Chitra Tirunal Institute for Medical Sciences and Technology examine the anti-colon cancer effects on Aloe-emodin (AE), a natural anthraquinone.
In colon cancer cell lines, AE inhibited cell proliferation by the cell cycle arrest at the G2/M phase and protein associated with cellular proliferation and division.
AE also induced cancer cell death by stimulating the function of proteins associated with pro-apoptosis.
In order to obtain additional information related to the Aloe vera anti-colon cancer activity, researchers analyzed the molecular mechanisms involved in the anti-migratory and antiangiogenic activity of this hydroxy anthraquinone.
AE suppressed the phorbol-12-myristyl-13-acetate (PMA), a diester of phorbol in the promotion of promotes tumor expression through migration and invasion.
AE also inhibited the mRNA expression of colon cancer cells and the matrixes involved malignant tumor growth, invasion, and metastasis and gene associated with the signaling in the formation and dissemination of a range of cancers.
Furthermore, EA inhibited the Vascular Endothelial Growth Factor (VEGF) expression in forming a new blood vessel in the promotion of endothelial cell migration/invasion.
Moreover, AE also suppressed the protein complex that controls the transcription of DNA, cytokine production and cell survival.
Researchers wrote in the summary of the experiment, "These data indicate that AE target multiple molecules responsible for cellular invasion, migration and angiogenesis" and Inhibitory effect on angiogenic and metastatic regulatory processes make AE a sensible candidate as a specific blocker of tumor-associated events".
Taken altogether, herbal Aloe vera processed a major bioactive compound Aloe-emodin may be considered a functional remedy for the prevention and combined with conventional medicine for the treatment of colon cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Aloe emodin induces G2/M cell cycle arrest and apoptosis via activation of caspase-6 in human colon cancer cells by Suboj P, Babykutty S, Srinivas P, Gopala S.(PubMed)
(2) Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB by Suboj P, Babykutty S, Valiyaparambil Gopi DR, Nair RS, Srinivas P, Gopala S.(PubMed)
(3) Dietary Patterns and Colon Cancer Risk in Whites and African Americans in the North Carolina Colon Cancer Study by Jessie A. Satia, Marilyn Tseng, Joseph A. Galanko, Christopher Martin, and Robert S. Sandler. (PMC)
(4) Western diet increases colorectal cancer risk in Japanese women: Cohort study by 25-Jul-2017 By Gary Scattergood. (NUTRA)
Artichoke Normalizes the Level of Total Lipids Profile
On seeking natural therapy with no side effects, scientists may have a whole fruit for the normalization of total high blood cholesterol, according to studies.
Total lipids profile is a lab test that measures the abnormal levels of cholesterol and triglycerides that can lead to cardiovascular disease.
The healthy level of low-density cholesterol is less than 70 mg/dL for those in very high-risk patients, 100 mg/dL for high-risk patients and 130 mg/dL for individuals who are at low risk for coronary artery disease.
The healthy level of high-density cholesterol is any number that is higher than 40 mg/dl.
The healthy level of triglycerides (TG) is any number that is less than 150 mg/dl.
Where dl is milligrams per deciliter
Total cholesterol is the total amount of cholesterol in the blood using the formula HDL level + LDL level + 20 percent of triglyceride level from the results of the total lipids profile.
The healthy levels of total cholesterol can be classified as follows
Optimal level: Less than 200 mg/dL
Normal high level: 200-239 mg/dL
High level: 240 mg/dL and above
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
On finding a natural remedy in the reducing risk and treatment of cardiovascular disease, researchers examined the artichoke in the subjects with hypercholesterolemia.
After 2 months of treatment, injection of artichoke showed a significant reduction in plasma total cholesterol (-19%), low-density lipoprotein cholesterol (-16%), non-high-density lipoprotein cholesterol (-19%) and triglyceride levels (-15%), compared to a standard diet.
There were no side effects found in the tested subjects during the course of study.
Dr. Cicero AFG, the lead scientists wrote, "In the short-term, the tested nutraceutical has been shown to be well tolerated and effective, even if not containing any statin-like compound".
Dr. Santos HO in the study to investigate the effect of artichoke on lipid profile by searching the medical literature appraised the Cochrane, MEDLINE, and Web of Science databases, including articles published between 2000 and June 2018 on intervention in humans only.
The review on the selected studies suggested that
* ALE decreased serum LDL, total cholesterol and triglyceride concentrations.
* ALE showed no effect on the levels of HDL.
In details, according to the differentiation, ALE at doses of 2 to 3 g/d decreased 8-49 mg/dL for LDL concentration, 12-55 mg/dL for total cholesterol, and 11-51 mg/dL for triglycerides.
The improvement of the lipid profile of ALE was attributed to the components luteolin and chlorogenic acids found abundantly in artichoke.
Furthermore, the cardioprotective effect of ALE was associated with soluble fibers and inulin in the herb or food.
The findings clearly suggested that ALE protects the heart by improving the condition of the cluster associated with metabolic syndrome, particularly in blood cholesterol.
Taken together, artichoke may be considered a functional remedy for improving the lipid profile against diseases associated with hypercholesterolemia, pending to the confirmation of larger sample size and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Short-Term Effects of Dry Extracts of Artichokeand Berberis in Hypercholesterolemic Patients Without Cardiovascular Disease by Cicero AFG1, Fogacci F2, Bove M2, Giovannini M2, Veronesi M2, Borghi C. (PubMed)
(2) The effect of artichoke on lipid profile: A review of possible mechanisms of action by Santos HO1, Bueno AA2, Mota JF. (PubMed)
Total lipids profile is a lab test that measures the abnormal levels of cholesterol and triglycerides that can lead to cardiovascular disease.
The healthy level of low-density cholesterol is less than 70 mg/dL for those in very high-risk patients, 100 mg/dL for high-risk patients and 130 mg/dL for individuals who are at low risk for coronary artery disease.
The healthy level of high-density cholesterol is any number that is higher than 40 mg/dl.
The healthy level of triglycerides (TG) is any number that is less than 150 mg/dl.
Where dl is milligrams per deciliter
Total cholesterol is the total amount of cholesterol in the blood using the formula HDL level + LDL level + 20 percent of triglyceride level from the results of the total lipids profile.
The healthy levels of total cholesterol can be classified as follows
Optimal level: Less than 200 mg/dL
Normal high level: 200-239 mg/dL
High level: 240 mg/dL and above
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
On finding a natural remedy in the reducing risk and treatment of cardiovascular disease, researchers examined the artichoke in the subjects with hypercholesterolemia.
After 2 months of treatment, injection of artichoke showed a significant reduction in plasma total cholesterol (-19%), low-density lipoprotein cholesterol (-16%), non-high-density lipoprotein cholesterol (-19%) and triglyceride levels (-15%), compared to a standard diet.
There were no side effects found in the tested subjects during the course of study.
Dr. Cicero AFG, the lead scientists wrote, "In the short-term, the tested nutraceutical has been shown to be well tolerated and effective, even if not containing any statin-like compound".
Dr. Santos HO in the study to investigate the effect of artichoke on lipid profile by searching the medical literature appraised the Cochrane, MEDLINE, and Web of Science databases, including articles published between 2000 and June 2018 on intervention in humans only.
The review on the selected studies suggested that
* ALE decreased serum LDL, total cholesterol and triglyceride concentrations.
* ALE showed no effect on the levels of HDL.
In details, according to the differentiation, ALE at doses of 2 to 3 g/d decreased 8-49 mg/dL for LDL concentration, 12-55 mg/dL for total cholesterol, and 11-51 mg/dL for triglycerides.
The improvement of the lipid profile of ALE was attributed to the components luteolin and chlorogenic acids found abundantly in artichoke.
Furthermore, the cardioprotective effect of ALE was associated with soluble fibers and inulin in the herb or food.
The findings clearly suggested that ALE protects the heart by improving the condition of the cluster associated with metabolic syndrome, particularly in blood cholesterol.
Taken together, artichoke may be considered a functional remedy for improving the lipid profile against diseases associated with hypercholesterolemia, pending to the confirmation of larger sample size and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Short-Term Effects of Dry Extracts of Artichokeand Berberis in Hypercholesterolemic Patients Without Cardiovascular Disease by Cicero AFG1, Fogacci F2, Bove M2, Giovannini M2, Veronesi M2, Borghi C. (PubMed)
(2) The effect of artichoke on lipid profile: A review of possible mechanisms of action by Santos HO1, Bueno AA2, Mota JF. (PubMed)
Herbal Ashwagandha Improved Muscle Mass and Strength In Exercise
The Muscle is a soft tissue in the body containing protein filaments of actin and myosin that slide past one another, with a function to produce force and motion.
In other words, muscle contraction and expansion that changes both the length and the shape allow us to move and lift.
Muscle mass is the calculation of the weight of the muscles in the body in kilograms or pounds. However, other factors may also interfere with the above calculation including height, ethnicity, and fitness level.
Increased muscle mass is associated with lower fat accumulation and the ability to burn calories/energy.
Some researchers suggested, by boosting your muscle mass, you will also improve your health, including* Boosts your metabolism. Dr. Alexandra C. McPherron, the lead scientist said, "increasing skeletal muscle mass by inhibiting signaling of myostatin, a transforming growth factor β (TGFβ) family member that negatively regulates muscle growth, prevents the development of diabetes in a mouse model of lipodystrophy. Muscle-specific myostatin inhibition also prevented hyperphagia suggesting muscle may regulate food intake".
In other words, increasing muscle mass improves your body's metabolism.
* Improves Bone Mass. Dr. Colletti LAand colleagues said, "additional evidence that muscle-building exercise is associated with increases in BMD at weight-bearing sites but not at on weight-bearing sites".
* Reduces fat accumulation. Dr. Silva TR, the lead scientist wrote, "Skeletal muscle mass index (SMI) was positively correlated with physical activity (r = 0.205, P = 0.038) and protein intake (r = 0.334, P = 0.001), and negatively correlated with waist circumference (r = -0.505, P < 0.001) and %body fat (r = 0.808, P < 0.001)".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent anti-aging compound, researchers examined the effects of ashwagandha root extract on muscle mass and strength in healthy young men engaged in resistance training.
The randomized, prospective, double-blind, placebo-controlled clinical study included 57 young male subjects (18-50 years old) with little experience in resistance training randomized into treatment received 300 mg of ashwagandha root extract twice daily, (29 subjects) and placebo, consumed starch placebos (28 subjects) groups.
Besides baseline measurements, both groups also underwent resistance training for 8 weeks with measurements repeated at the end of week 8.
Based on the results of measurement of the participants in both groups, compared to placebo, the treatment group showed significantly greater increases i
* In muscle strength on the bench-press exercise (Placebo: 26.4 kg vs. Ashwagandha: 46.0 kg)
* In the leg-extension exercise (Placebo: 9.8 kg) vs. Ashwagandha: 14.5 kg)
* In muscle size increase at the arms (Placebo: 5.3 cm(2) vs. Ashwagandha: 8.6 cm(2))
* In chest (Placebo: 1.4 cm vs. Ashwagandha: 3.3 cm).
Furthermore, ashwagandha treated group also had a significantly greater reduction of exercise-induced muscle damage.
Moreover, Ashwagandha treated group also showed a significantly greater increase in testosterone level (Placebo: 18.0 ng/dL Ashwagandha: 96.2 ng/dL)
More importantly, there was a significantly greater decrease in body fat percentage in the treatment group compared to placebo (Placebo: 1.5% vs. Ashwagandha: 3.5%).
Based on the finding, researchers wrote, "ashwagandha supplementation is associated with significant increases in muscle mass and strength and suggests that ashwagandha supplementation may be useful in conjunction with a resistance training program".
Taken altogether, Ashwagandha may be used as a supplement for the improvement of muscle mass and strength in the resistance training program, pending to the results from the large sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial by Wankhede S1, Langade D2, Joshi K3, Sinha SR4, Bhattacharyya S. (PubMed)
(2) Increasing muscle mass to improve metabolism by Alexandra C. McPherron, Tingqing Guo, Nichole D. Bond, and Oksana Gavrilova. (PMC)
(3) The effects of muscle-building exercise on bone mineral density of the radius, spine, and hip in young men by Colletti LA1, Edwards J, Gordon L, Shary J, Bell NH. (PubMed)
(4) Skeletal muscle mass is associated with higher dietary protein intake and lower body fat in postmenopausal women: a cross-sectional study by Silva TR1, Spritzer PM. (PubMed)
In other words, muscle contraction and expansion that changes both the length and the shape allow us to move and lift.
Muscle mass is the calculation of the weight of the muscles in the body in kilograms or pounds. However, other factors may also interfere with the above calculation including height, ethnicity, and fitness level.
Increased muscle mass is associated with lower fat accumulation and the ability to burn calories/energy.
Some researchers suggested, by boosting your muscle mass, you will also improve your health, including* Boosts your metabolism. Dr. Alexandra C. McPherron, the lead scientist said, "increasing skeletal muscle mass by inhibiting signaling of myostatin, a transforming growth factor β (TGFβ) family member that negatively regulates muscle growth, prevents the development of diabetes in a mouse model of lipodystrophy. Muscle-specific myostatin inhibition also prevented hyperphagia suggesting muscle may regulate food intake".
In other words, increasing muscle mass improves your body's metabolism.
* Improves Bone Mass. Dr. Colletti LAand colleagues said, "additional evidence that muscle-building exercise is associated with increases in BMD at weight-bearing sites but not at on weight-bearing sites".
* Reduces fat accumulation. Dr. Silva TR, the lead scientist wrote, "Skeletal muscle mass index (SMI) was positively correlated with physical activity (r = 0.205, P = 0.038) and protein intake (r = 0.334, P = 0.001), and negatively correlated with waist circumference (r = -0.505, P < 0.001) and %body fat (r = 0.808, P < 0.001)".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent anti-aging compound, researchers examined the effects of ashwagandha root extract on muscle mass and strength in healthy young men engaged in resistance training.
The randomized, prospective, double-blind, placebo-controlled clinical study included 57 young male subjects (18-50 years old) with little experience in resistance training randomized into treatment received 300 mg of ashwagandha root extract twice daily, (29 subjects) and placebo, consumed starch placebos (28 subjects) groups.
Besides baseline measurements, both groups also underwent resistance training for 8 weeks with measurements repeated at the end of week 8.
Based on the results of measurement of the participants in both groups, compared to placebo, the treatment group showed significantly greater increases i
* In muscle strength on the bench-press exercise (Placebo: 26.4 kg vs. Ashwagandha: 46.0 kg)
* In the leg-extension exercise (Placebo: 9.8 kg) vs. Ashwagandha: 14.5 kg)
* In muscle size increase at the arms (Placebo: 5.3 cm(2) vs. Ashwagandha: 8.6 cm(2))
* In chest (Placebo: 1.4 cm vs. Ashwagandha: 3.3 cm).
Furthermore, ashwagandha treated group also had a significantly greater reduction of exercise-induced muscle damage.
Moreover, Ashwagandha treated group also showed a significantly greater increase in testosterone level (Placebo: 18.0 ng/dL Ashwagandha: 96.2 ng/dL)
More importantly, there was a significantly greater decrease in body fat percentage in the treatment group compared to placebo (Placebo: 1.5% vs. Ashwagandha: 3.5%).
Based on the finding, researchers wrote, "ashwagandha supplementation is associated with significant increases in muscle mass and strength and suggests that ashwagandha supplementation may be useful in conjunction with a resistance training program".
Taken altogether, Ashwagandha may be used as a supplement for the improvement of muscle mass and strength in the resistance training program, pending to the results from the large sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial by Wankhede S1, Langade D2, Joshi K3, Sinha SR4, Bhattacharyya S. (PubMed)
(2) Increasing muscle mass to improve metabolism by Alexandra C. McPherron, Tingqing Guo, Nichole D. Bond, and Oksana Gavrilova. (PMC)
(3) The effects of muscle-building exercise on bone mineral density of the radius, spine, and hip in young men by Colletti LA1, Edwards J, Gordon L, Shary J, Bell NH. (PubMed)
(4) Skeletal muscle mass is associated with higher dietary protein intake and lower body fat in postmenopausal women: a cross-sectional study by Silva TR1, Spritzer PM. (PubMed)
Herbal Burdock, The Herb Which Protects You Against Digestive Disorders
Herbal Burdock may have a potential effect in the protection of your gastrointestinal tract against the
Gastroprotective activity is an action which maintains the function of the digestive system against pathogens in the induction of gastric lesions.
The digestive system including the gastrointestinal (GI) tract, the liver, pancreas, and gallbladder process the function to digest foods and transfer the nutrients and fluids to the body's needs.
There is no single cause of the gastrointestinal disorder. Researchers suggested that the cause of the disorder can be attributed directly to the digestive system, or other systemic problems that facilitate the onset of disease.
However, according to the epidemiological studies, bacterial infection, viral infection, inflammation, muscle dysfunction, gallstones, stress, and intake of certain anti-inflammatory drugs are associated with the onset of the acute and chronic digestive disorders.
Dietary factors also play an important in the reduction and promotion of digestive dysfunction. people who are overeating, eating too much fatty food, not consuming enough fiber, and consuming too much alcohol and smoking are at a higher risk of digestive diseases, including ulcers and gastric acid reflux.
Dr. Linda Lee, M.D. in the article "5 Foods to Improve Your Digestion" posted on the John Hopkins Medicine shares five foods that promote healthier digestion and help you avoid common gastrointestinal symptoms, including whole grain, leafy green, lean protein, low fructose fruits, and avocado.
These results suggested if you are following a healthy diet with less saturated and trans fat, red meat and processed foods and increased intake of fruit and vegetables, you may be free of gastrointestinal disorders.
Dr. Hyams JS at the University of Connecticut School of Medicine and Division of Digestive Diseases and Nutrition in the study "Diet and gastrointestinal disease" said, "Dietary manipulation can be an important part of therapy for several common gastrointestinal disorders" and " In chronic nonspecific diarrhea and functional constipation, the provision of appropriate amounts of fiber and fluids may ameliorate symptoms. A thorough understanding of the role of diet is essential to the management of these disorders".
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro.
The herb has been used thousands of years in Chinese and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
In the study to reaffirm the traditional medicine use of herbal burdock for the treatment of digestive disorders, researchers at the State University of Campinas conducted an evaluation to examine the anti-ulcerogenic activity of the sesquiterpene onopordopicrin (ONP)-enriched fraction (termed the ONP fraction), obtained from burdock leaves.
In vivo models in rodents, mimicking this disease in humans. injection of ONP fraction (50 mg/kg, p.o.) significantly inhibited the mucosal injury induced by ethanol/HCl solution by 75%, indomethacin/bethanechol by 68.9%, and stress by 58.3% compared to nontreatment groups.
ONP fraction application also significantly increased serum somatostatin levels (82.1±4.1 vs. control group 12.7±4 pmol/L) and decreased serum gastrin levels (62.6±6.04 vs. control group 361.5±8.2 μU/mL) without alternating the altered the mucus production.
Further analysis found that gastrointestinal protection is attributed to the endogenous sulfhydryls in the ONP fraction.
Dr.de Almeida AB, at the final report, wrote, "antisecretory mechanism involved with the antiulcerogenic effect of the ONP fraction.
Additionally, in the study to evaluate the efficacy and the possible mechanisms involved in the gastroprotective effects of a chloroform extract (CE) of the roots from A. lappa and its fractions.conducted by the Universidade Federal do Paraná, researchers found that
* Oral pretreatment with CE (10, 30 and 100 mg kg(-1)) significantly reduced gastric lesions induced by ethanol by 61%, 70%, and 76%, respectively.
*Oral administration of CE (100 mg kg(-1) per day for 7 days) reduced the chronic gastric ulceration induced by acetic acid by 52%. Intraduodenal CE (100, 300 and 600 mg kg(-1)) reduced the total acidity of gastric secretion by 22%, 22% and 33%, respectively,
* Oral administration (10, 30 and 100 mg kg(-1)) inhibited total acidity by 50%, 60% and 67%, respectively.
These results reaffirm the study of the State University of Campinas that Herbal Burdock processes a significantly gastroprotective effect.
Dr. Dos Santos AC, the lead author after taking into account of con and confounder said, " the CE protects animals from gastric lesions by reducing gastric acid secretion via inhibition of gastric H+, K+ -ATPase."
Taken all together, Herbal Burdock processed bioactive ONP fraction and its chloroform extract (CE) may be considered functional food for the prevention and combines with the conventional medicine for treatment for gastrointestinal diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-ulcerogenic mechanisms of the sesquiterpene lactone onopordopicrin-enriched fraction from Arctium lappa L. (Asteraceae): the role of somatostatin, gastrin, and endogenous sulfhydryls and nitric oxide by de Almeida AB, Luiz-Ferreira A, Cola M, Di Pietro Magri L, Batista LM, de Paiva JA, Trigo JR, Souza-Brito AR. (PubMed)
(2) Gastroprotective activity of the chloroform extract of the roots from Arctium lappa L by Dos Santos AC, Baggio CH, Freitas CS, Lepieszynski J, Mayer B, Twardowschy A, Missau FC, dos Santos EP, Pizzolatti MG, Marques MC. (PubMed)
(3) Diet and gastrointestinal disease by Hyams JS(PubMed)
Gastroprotective activity is an action which maintains the function of the digestive system against pathogens in the induction of gastric lesions.
The digestive system including the gastrointestinal (GI) tract, the liver, pancreas, and gallbladder process the function to digest foods and transfer the nutrients and fluids to the body's needs.
There is no single cause of the gastrointestinal disorder. Researchers suggested that the cause of the disorder can be attributed directly to the digestive system, or other systemic problems that facilitate the onset of disease.
However, according to the epidemiological studies, bacterial infection, viral infection, inflammation, muscle dysfunction, gallstones, stress, and intake of certain anti-inflammatory drugs are associated with the onset of the acute and chronic digestive disorders.
Dietary factors also play an important in the reduction and promotion of digestive dysfunction. people who are overeating, eating too much fatty food, not consuming enough fiber, and consuming too much alcohol and smoking are at a higher risk of digestive diseases, including ulcers and gastric acid reflux.
Dr. Linda Lee, M.D. in the article "5 Foods to Improve Your Digestion" posted on the John Hopkins Medicine shares five foods that promote healthier digestion and help you avoid common gastrointestinal symptoms, including whole grain, leafy green, lean protein, low fructose fruits, and avocado.
These results suggested if you are following a healthy diet with less saturated and trans fat, red meat and processed foods and increased intake of fruit and vegetables, you may be free of gastrointestinal disorders.
Dr. Hyams JS at the University of Connecticut School of Medicine and Division of Digestive Diseases and Nutrition in the study "Diet and gastrointestinal disease" said, "Dietary manipulation can be an important part of therapy for several common gastrointestinal disorders" and " In chronic nonspecific diarrhea and functional constipation, the provision of appropriate amounts of fiber and fluids may ameliorate symptoms. A thorough understanding of the role of diet is essential to the management of these disorders".
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro.
The herb has been used thousands of years in Chinese and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
In the study to reaffirm the traditional medicine use of herbal burdock for the treatment of digestive disorders, researchers at the State University of Campinas conducted an evaluation to examine the anti-ulcerogenic activity of the sesquiterpene onopordopicrin (ONP)-enriched fraction (termed the ONP fraction), obtained from burdock leaves.
In vivo models in rodents, mimicking this disease in humans. injection of ONP fraction (50 mg/kg, p.o.) significantly inhibited the mucosal injury induced by ethanol/HCl solution by 75%, indomethacin/bethanechol by 68.9%, and stress by 58.3% compared to nontreatment groups.
ONP fraction application also significantly increased serum somatostatin levels (82.1±4.1 vs. control group 12.7±4 pmol/L) and decreased serum gastrin levels (62.6±6.04 vs. control group 361.5±8.2 μU/mL) without alternating the altered the mucus production.
Further analysis found that gastrointestinal protection is attributed to the endogenous sulfhydryls in the ONP fraction.
Dr.de Almeida AB, at the final report, wrote, "antisecretory mechanism involved with the antiulcerogenic effect of the ONP fraction.
Additionally, in the study to evaluate the efficacy and the possible mechanisms involved in the gastroprotective effects of a chloroform extract (CE) of the roots from A. lappa and its fractions.conducted by the Universidade Federal do Paraná, researchers found that
* Oral pretreatment with CE (10, 30 and 100 mg kg(-1)) significantly reduced gastric lesions induced by ethanol by 61%, 70%, and 76%, respectively.
*Oral administration of CE (100 mg kg(-1) per day for 7 days) reduced the chronic gastric ulceration induced by acetic acid by 52%. Intraduodenal CE (100, 300 and 600 mg kg(-1)) reduced the total acidity of gastric secretion by 22%, 22% and 33%, respectively,
* Oral administration (10, 30 and 100 mg kg(-1)) inhibited total acidity by 50%, 60% and 67%, respectively.
These results reaffirm the study of the State University of Campinas that Herbal Burdock processes a significantly gastroprotective effect.
Dr. Dos Santos AC, the lead author after taking into account of con and confounder said, " the CE protects animals from gastric lesions by reducing gastric acid secretion via inhibition of gastric H+, K+ -ATPase."
Taken all together, Herbal Burdock processed bioactive ONP fraction and its chloroform extract (CE) may be considered functional food for the prevention and combines with the conventional medicine for treatment for gastrointestinal diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-ulcerogenic mechanisms of the sesquiterpene lactone onopordopicrin-enriched fraction from Arctium lappa L. (Asteraceae): the role of somatostatin, gastrin, and endogenous sulfhydryls and nitric oxide by de Almeida AB, Luiz-Ferreira A, Cola M, Di Pietro Magri L, Batista LM, de Paiva JA, Trigo JR, Souza-Brito AR. (PubMed)
(2) Gastroprotective activity of the chloroform extract of the roots from Arctium lappa L by Dos Santos AC, Baggio CH, Freitas CS, Lepieszynski J, Mayer B, Twardowschy A, Missau FC, dos Santos EP, Pizzolatti MG, Marques MC. (PubMed)
(3) Diet and gastrointestinal disease by Hyams JS(PubMed)
Wednesday, November 20, 2019
Herbal Burdock Kills Breast Cancer Cells In Vivo and Vitro
Scientists may have found a whole herb that processes a significant effect in reducing the risk and treatment of breast cancer with no side effects, according to some studies.
Breast cancer is a chronic condition characterized by cell growth controllably and disorderly in the breast tissue.
Most cases of breast cancer start at the cells on the surface of the inner lining tissue of the breast. At this stage, most patients may experience symptoms of lump on part of the breast, swelling, nipple pain and redness and scaliness. If you have some of the above which can not resolve within 3 weeks, please check with your doctor to rule out the possibility of breast cancer.
At the advanced stage, after penetrating into the deeper layers of the breast, malignant cells may travel a distance far the way from the breast to infect other healthy tissue and organs, through the blood and fluids circulation.
In this stage, the breast tumor is growing large enough to suppress the nearby healthy tissue and nerve cells, causing severe localized symptoms and pain.
The liver, brain, bones, or lungs are most commonly organs for breast cancer metastasis.
According to a statistic provided by the cancer society, women in Canada have a lifetime risk of breast cancer incidence rates of 11%. In other words, 11% of Canadian women will develop breast cancer by the time they reach 90 years of age.
Only 20% of breast cancers in Canada are diagnosed in women under 50, compared to almost 30% diagnosed in women over 70 years of age.
The 5 years survival rate of breast cancer is 100% compared to 89% in the 10 years survival rate.
Therefore, early diagnosis is a key factor to improve the survival rate and prevent a long-term painful
treatment with many unpleasant side effects if the cancer is found in the later stage.
Women are encouraged to examine their breast every month if you found any changes that not in 3 not recover within 3 weeks, please check with your doctor as soon as possible.
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro.
The plant has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
The chemical ingredients of herbal Burdock include guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.
In finding the natural compound with no side effects, researchers examine the anticancer effect of arctigenin (ATG), a natural lignan product of Herbal Burdock (Arctium lappa L.), in human breast cancer MDA-MB-231 cells.
Application of arctigenin (ATG) showed potency in inhibiting the MDA-MB-231 cell growth by inducing apoptosis.
ATG stimulated breast cancer cell death programming by reducing the ration expression of Bax/Bcl-2.
Furthermore, ATG also activated the overexpression of free radicals in the induction of cytotoxicity to the breast cancer cell line.
These results suggested that ATG induced cancer apoptosis through many different mechanisms, including the pathways in stimulating the expression of ROS that causes cytotoxicity and promoting cell death.
Additionally, in reaffirming the anti-breast cancer of herbal burdock, researchers conducted an experiment to evaluate the anti-cancer properties of Arctiin, a major lignan constituent of Arctium lappa (Burdock) in animal models.
In human breast cancer MCF-7 cells, injection of Arctiin demonstrated a significant effect in the inhibition of the breast cancer cells associated with the decreasing the function of the protein in promoting the cell cycle division.
Moreover, the application of Arctiin also increased the function of the protein associated with the suppressor in acting to inhibit cell proliferation and tumor development.
Taken together, Herbal Burdock may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of breast cancer.
However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of herbal Burdock anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation by Hsieh CJ, Kuo PL, Hsu YC, Huang YF, Tsai EM, Hsu YL. (PubMed)
(2) Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression by Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, Germain D, Sakai T.(PubMed)
Breast cancer is a chronic condition characterized by cell growth controllably and disorderly in the breast tissue.
Most cases of breast cancer start at the cells on the surface of the inner lining tissue of the breast. At this stage, most patients may experience symptoms of lump on part of the breast, swelling, nipple pain and redness and scaliness. If you have some of the above which can not resolve within 3 weeks, please check with your doctor to rule out the possibility of breast cancer.
At the advanced stage, after penetrating into the deeper layers of the breast, malignant cells may travel a distance far the way from the breast to infect other healthy tissue and organs, through the blood and fluids circulation.
In this stage, the breast tumor is growing large enough to suppress the nearby healthy tissue and nerve cells, causing severe localized symptoms and pain.
The liver, brain, bones, or lungs are most commonly organs for breast cancer metastasis.
According to a statistic provided by the cancer society, women in Canada have a lifetime risk of breast cancer incidence rates of 11%. In other words, 11% of Canadian women will develop breast cancer by the time they reach 90 years of age.
Only 20% of breast cancers in Canada are diagnosed in women under 50, compared to almost 30% diagnosed in women over 70 years of age.
The 5 years survival rate of breast cancer is 100% compared to 89% in the 10 years survival rate.
Therefore, early diagnosis is a key factor to improve the survival rate and prevent a long-term painful
treatment with many unpleasant side effects if the cancer is found in the later stage.
Women are encouraged to examine their breast every month if you found any changes that not in 3 not recover within 3 weeks, please check with your doctor as soon as possible.
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro.
The plant has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
The chemical ingredients of herbal Burdock include guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.
In finding the natural compound with no side effects, researchers examine the anticancer effect of arctigenin (ATG), a natural lignan product of Herbal Burdock (Arctium lappa L.), in human breast cancer MDA-MB-231 cells.
Application of arctigenin (ATG) showed potency in inhibiting the MDA-MB-231 cell growth by inducing apoptosis.
ATG stimulated breast cancer cell death programming by reducing the ration expression of Bax/Bcl-2.
Furthermore, ATG also activated the overexpression of free radicals in the induction of cytotoxicity to the breast cancer cell line.
These results suggested that ATG induced cancer apoptosis through many different mechanisms, including the pathways in stimulating the expression of ROS that causes cytotoxicity and promoting cell death.
Additionally, in reaffirming the anti-breast cancer of herbal burdock, researchers conducted an experiment to evaluate the anti-cancer properties of Arctiin, a major lignan constituent of Arctium lappa (Burdock) in animal models.
In human breast cancer MCF-7 cells, injection of Arctiin demonstrated a significant effect in the inhibition of the breast cancer cells associated with the decreasing the function of the protein in promoting the cell cycle division.
Moreover, the application of Arctiin also increased the function of the protein associated with the suppressor in acting to inhibit cell proliferation and tumor development.
Taken together, Herbal Burdock may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of breast cancer.
However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of herbal Burdock anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation by Hsieh CJ, Kuo PL, Hsu YC, Huang YF, Tsai EM, Hsu YL. (PubMed)
(2) Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression by Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, Germain D, Sakai T.(PubMed)
Subscribe to:
Posts (Atom)