Aloe Vera may be used as potential herbal medicine in enhanced immune function in promoted immunostimulatory and immunomodulatory expression.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan, used in herbal medicine in treating various diseases, including wound, burn to heal, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.
The immunomodulatory effect is an action involved regulation of the immune system against the invasion of foreign subjects in promoted infection and inflammation.
According to the joint study led by the Sahlgrenska Academy at the University of Gothenburg, orally administrated (AVH200®), an aloe vera extract modified the protein involved activation, proliferation and cytokine secretion of healthy human blood T cells, in a dose-dependent manner.
Aloe-emodin(AE), a major constituent found in Aloe Vera exerted a positive effect in significantly enhanced dabrafenib (a BARF inhibitor) antiproliferative activity of mutant cell lines through immunomodulatory activity
The study also confirmed that AE possesses remarkable antineoplastic properties of the drug(dabrafenib) used in the treatment of metastatic colon cancer, against melanoma cells.
In candida Albicans, A. vera extract and its fractions on infected macrophages demonstrated an antifungal effect through activated and modulated the immune response.
Furthermore, the extract also significantly increased the cell viability of macrophages, in comparison with the control group.
Additionally, a polysaccharide isolated from Aloe Vera explicitly also enhanced immune function in producing specific antibody and inducing delayed hypersensitivity in mice model.
Collectively, chemical constituents found in Aloe vera have shown to exhibit immunomodulatory effects in regulated immune function against foreign invasion and allergic reactions and irregular cell growth, but further studies are necessary to confirm this validation.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Effects of Aloe barbadensis Mill. extract (AVH200®) on human blood T cell activity in vitro by Ahluwalia B1, Magnusson MK2, Isaksson S3, Larsson F4, Öhman L5.(PubMed)
(2) Aloe-emodin exerts a potent anticancer and immunomodulatory activity on BRAF-mutated human melanoma cells by Tabolacci C1, Cordella M2, Turcano L3, Rossi S2, Lentini A3, Mariotti S4, Nisini R4, Sette G5, Eramo A2, Piredda L3, De Maria R5, Facchiano F6, Beninati S3.(PubMed)
(3) Immunomodulatory effects of Aloe vera and its fractions on response of macrophages against Candida albicans by Farahnejad Z1, Ghazanfari T, Yaraee R(PubMed)
(4) An anti-complementary polysaccharide with immunological adjuvant activity from the leaf parenchyma gel of Aloe vera by t'Hart LA, van den Berg AJ, Kuis L, van Dijk H, Labadie RP.(PubMed)
Saturday, December 14, 2019
Green Tea and Green Tea Epigallocatechin Gallate (EGCG) In Protection and Treatment of Retinal Degenerative Disease
Green tea phenolic content may have a sustainable and therapeutic effect in reduced risk and progression of retinal degeneration, some scientists suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Retinal degeneration is a macular disease characterized by impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision.
The evaluation of green tea effect in the risk of retinal degeneration was found to be implicated by several mechanisms through a number of aspects.
In ROS implication of oxidative stress-induced degeneration of the retina occurred in age-related macular degeneration (AMD) and glaucoma, application of green tea polyphenols epigallocatechin gallate (EGCG) exhibited antioxidant effect as free radical scavenger in ameliorated chain reaction of ROS in causing loss of neuron with direct effects of retinal function and reduced cytotoxicity of free radicals in induction of retinal cellular apoptosis.
Administration of green tea phenolic compound exerted 10 times more effective in the treatment of retinal degeneration, compared to potent medicine trolox (vitamin E analogue) in attenuating lipid peroxidation caused by the nitric oxide donor, sodium nitroprusside (SNP), according to the study.
Particularly, green tea epigallocatechin gallate (EGCG) inhibited a significant decrease in photoreceptor-specific markers (RET-P1, rhodopsin kinase) which may be an indication of photoreceptor cells in the transition to degenerate prematurely, eventually resulting in blindness and an increase in the cell death marker caspase-3 caused by oxidative stress induced by injection of sodium nitroprusside (SNP)
According to the observation by Western blotting techniques, SNP was completely inhibited by EGCG injection in ameliorated the detrimental effects to the retina caused by SNP.
Dr. Zhang B, the co-author said, "Since oxidative stress has been implicated in retinal diseases like AMD and glaucoma this study provides "proof of principle" for the idea that daily intake of EGCG may help individuals suffering from retinal diseases where oxidative stress is implicated".
More interestingly, in BALB/cJ mice treated with either EGCG or saline via intraperitoneal (IP) injection, and then placed under constant cool white light-emitting diode (LED) light (10,000 lux) for 5 h, EGCG treatment group showed a strong protective effect on the retina against light damage (LD) in compared to the control group.
According to the optical coherence tomography (OCT) and electroretinography (ERG), in the examine the retinal structure and function after LD indicated that the application of green tea EGCG improved significantly higher ERG amplitudes for all three wave types through inducing morphologic protection of photoreceptors also in compared to control.
Moreover, the green tea extract bio-compound also decreased oxidative stress through increase the mRNA level of the antioxidant expression of Sod2, a manganese-dependent superoxide dismutase (MnSOD) before LD and 24 h after LD.
Dr. Qi S1,, the lead author said, "The IP injection of EGCG attenuated the detrimental effects of bright light on the retinas of BALB/cJ mice by protecting the structure and function of the retina".
Importantly, in study to evaluate green tea EGCG effect in reduced glutamate-induced excitotoxicity in the retina, researchers conducted a study of female Wistar rats (n = 171) randomly signed into a normal control group (n = 9); saline control group with intravitreal saline injections (n = 54); NMDA control group with an intravitreal NMDA injection and intraperitoneal saline injections (n = 54); and NMDA study group (n = 54) receiving an intravitreal NMDA injection plus intraperitoneal EGCG (25 mg/kg) injections, observation of the groups at 2 weeks after additional injection of NMDA showed that group with treatment of intraperitoneal application of EGCG reduced a significantly less marked NMDA-associated loss of retinal ganglion cell, through inhibition of decreasing retinal ganglion cell layer (GCL), neurons located near the inner surface (the ganglion cell layer) of the retina of the eye in received visual information from photoreceptors via cell density and thickness of Thy-1 immunoreactivity in several areas of the immature and adult human brain in expression of retinal ganglion cell damage.
Taken together, there is no doubt that Epigallocatechin-3-gallate (EGCG), a major polyphenol of green tea, may be considered as a secondary therapeutic treatment used a combination with standard therapy for protection and treatment of retinal degenerative disease
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299Sources
(1) Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate by Zhang B1, Osborne NN(PubMed)
(2) Neuroprotective effect of epigallocatechin-3-gallate against N-methyl-D-aspartate-induced excitotoxicity in the adult rat retina by Chen F1, Jiang L, Shen C, Wan H, Xu L, Wang N, Jonas JB(PubMed)
(3) Intraperitoneal injection of (-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina by Qi S1,2, Wang C1,2, Song D2, Song Y2, Dunaief JL2.(PubMed)--
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Retinal degeneration is a macular disease characterized by impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision.
The evaluation of green tea effect in the risk of retinal degeneration was found to be implicated by several mechanisms through a number of aspects.
In ROS implication of oxidative stress-induced degeneration of the retina occurred in age-related macular degeneration (AMD) and glaucoma, application of green tea polyphenols epigallocatechin gallate (EGCG) exhibited antioxidant effect as free radical scavenger in ameliorated chain reaction of ROS in causing loss of neuron with direct effects of retinal function and reduced cytotoxicity of free radicals in induction of retinal cellular apoptosis.
Administration of green tea phenolic compound exerted 10 times more effective in the treatment of retinal degeneration, compared to potent medicine trolox (vitamin E analogue) in attenuating lipid peroxidation caused by the nitric oxide donor, sodium nitroprusside (SNP), according to the study.
Particularly, green tea epigallocatechin gallate (EGCG) inhibited a significant decrease in photoreceptor-specific markers (RET-P1, rhodopsin kinase) which may be an indication of photoreceptor cells in the transition to degenerate prematurely, eventually resulting in blindness and an increase in the cell death marker caspase-3 caused by oxidative stress induced by injection of sodium nitroprusside (SNP)
According to the observation by Western blotting techniques, SNP was completely inhibited by EGCG injection in ameliorated the detrimental effects to the retina caused by SNP.
Dr. Zhang B, the co-author said, "Since oxidative stress has been implicated in retinal diseases like AMD and glaucoma this study provides "proof of principle" for the idea that daily intake of EGCG may help individuals suffering from retinal diseases where oxidative stress is implicated".
More interestingly, in BALB/cJ mice treated with either EGCG or saline via intraperitoneal (IP) injection, and then placed under constant cool white light-emitting diode (LED) light (10,000 lux) for 5 h, EGCG treatment group showed a strong protective effect on the retina against light damage (LD) in compared to the control group.
According to the optical coherence tomography (OCT) and electroretinography (ERG), in the examine the retinal structure and function after LD indicated that the application of green tea EGCG improved significantly higher ERG amplitudes for all three wave types through inducing morphologic protection of photoreceptors also in compared to control.
Moreover, the green tea extract bio-compound also decreased oxidative stress through increase the mRNA level of the antioxidant expression of Sod2, a manganese-dependent superoxide dismutase (MnSOD) before LD and 24 h after LD.
Dr. Qi S1,, the lead author said, "The IP injection of EGCG attenuated the detrimental effects of bright light on the retinas of BALB/cJ mice by protecting the structure and function of the retina".
Importantly, in study to evaluate green tea EGCG effect in reduced glutamate-induced excitotoxicity in the retina, researchers conducted a study of female Wistar rats (n = 171) randomly signed into a normal control group (n = 9); saline control group with intravitreal saline injections (n = 54); NMDA control group with an intravitreal NMDA injection and intraperitoneal saline injections (n = 54); and NMDA study group (n = 54) receiving an intravitreal NMDA injection plus intraperitoneal EGCG (25 mg/kg) injections, observation of the groups at 2 weeks after additional injection of NMDA showed that group with treatment of intraperitoneal application of EGCG reduced a significantly less marked NMDA-associated loss of retinal ganglion cell, through inhibition of decreasing retinal ganglion cell layer (GCL), neurons located near the inner surface (the ganglion cell layer) of the retina of the eye in received visual information from photoreceptors via cell density and thickness of Thy-1 immunoreactivity in several areas of the immature and adult human brain in expression of retinal ganglion cell damage.
Taken together, there is no doubt that Epigallocatechin-3-gallate (EGCG), a major polyphenol of green tea, may be considered as a secondary therapeutic treatment used a combination with standard therapy for protection and treatment of retinal degenerative disease
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299Sources
(1) Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate by Zhang B1, Osborne NN(PubMed)
(2) Neuroprotective effect of epigallocatechin-3-gallate against N-methyl-D-aspartate-induced excitotoxicity in the adult rat retina by Chen F1, Jiang L, Shen C, Wan H, Xu L, Wang N, Jonas JB(PubMed)
(3) Intraperitoneal injection of (-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina by Qi S1,2, Wang C1,2, Song D2, Song Y2, Dunaief JL2.(PubMed)--
Fennel or Its Composition as Laxative Agent for Treatment of Chronic Constipation
Fennel may have a therapeutic effect for the treatment of chronic constipation, some scientists suggested.
Chronic constipation is a condition characterized by infrequent bowel movements in passing stool for weeks at a time.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.
According to the study of 24 patients with chronic non-specific colitis conducted by Dr. Chakŭrski I and colleagues, oral administration of a traditional combination of peppermint, licorice, and fennel exerted a significant activity in reduced spontaneous and palpable pains along the large intestine disappeared and induced daily defecation in the patients with obstipation syndrome.
Further differentiation suggested that the herbal formula demonstrated a potential effect in inhibited the colitis expression in reduced the colon function in reabsorbed fluids and processed waste products from the body and prepared for its elimination.
Some researchers suggested chronic constipation may be an intestinal microbiota imbalance related disease as herbal feed additive including fennel exerted significant effects in digestive disorders of weaning rabbits' intestinal microbiota, according to the study in compared the differences in the composition of the intestinal microbiota in constipated patients and healthy controls.
In fact, further analysis also found that patients with chronic constipation expressed alterations of intestinal microbiota composition characterized by decreased obligate bacteria (e.g. Lactobacillus, Bifidobacterium, and Bacteroides spp.) and a parallel increase of potentially pathogenic microorganisms (e.g. Pseudomonas aeruginosa and Campylobacter jejuni).
Long term imbalance of intestinal microbiota composition may associate with the prevalence of chronic constipation as increased pathogenic microorganisms may reduce intestinal motility and secretory functions by changing the amount of available physiologically active substances and the metabolic environment of the gut in the breakdown of food products into absorbable nutrients.
The above differentiation of the fennel composition effect was supported by an illustration of the study of formula Smooth move, a herbal tea used in some nursing care for residents with chronic constipation.
According to Dr. Bub S and colleagues in a total of 86 nursing home residents with chronic constipation randomly assigned to receive Smooth Move (n = 42) or a placebo (n = 44), once daily, in addition to standard treatment for chronic constipation for 28 days, oral administration of the formula showed a statistically significant increase in the number of bowel movements in compared to placebo group.
More precisely, participants treated with Smooth Move in compared to the nontreatment group experienced an average of 4.14 more bowel movements during the 28-day study period versus the 28-day pre-study period.
Interestingly, in the investigation of the laxative efficacy of composition of Pimpinella anisum L., Foeniculum vulgare Miller, Sambucus nigra L., and Cassia augustifolia used in Brazil for treatment of chronic constipation, researchers at the institution of conducted a randomized, crossover, placebo-controlled, single-blinded trial included 20 patients presenting with chronic constipation according to the criteria of the American Association of Gastroenterology, found that patients received the formula composition exerts a strong improvement of bowel function in compared to control.
However, the application fails to improve the quality of life in participants in reduced some symptoms associated with chronic constipation, except for a small reduction in serum potassium levels during the active treatment.
Dr. Picon PD, the lead author, after taking into account of other confounders, said, "phytotherapic compound assessed has laxative efficacy and is a safe alternative option for the treatment of constipation".
Taken together, fennel used alone or combined with other herbal medicine may be considered as a therapeutic treatment in patients with chronic participation without inducing any intolerable side effects.
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) [Treatment of chronic colitis with an herbal combination of Taraxacum officinale, Hipericum perforatum, Melissa officinaliss, Calendula officinalis and Foeniculumvulgare].[Article in Bulgarian] by Chakŭrski I, Matev M, Koĭchev A, Angelova I, Stefanov G.(PubMed)
(2) Efficacy of an herbal dietary supplement (Smooth Move) in the management of constipation in nursing home residents: A randomized, double-blind, placebo-controlled study by Bub S1, Brinckmann J, Cicconetti G, Valentine B.(PubMed)
(3) Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronicconstipation by Picon PD1, Picon RV, Costa AF, Sander GB, Amaral KM, Aboy AL, Henriques AT.(PubMed)
(4) Intestinal microbiota and chronic constipation by Ying Zhao and Yan-Bo Yu(PubMed)
(5) Performance, digestive disorders and the intestinal microbiota in weaning rabbits are affected by a herbal feed additive by R. Krieg, Wageha Awad, W Vahjen and Wilfried Vahjen(Research gate)
Chronic constipation is a condition characterized by infrequent bowel movements in passing stool for weeks at a time.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.
According to the study of 24 patients with chronic non-specific colitis conducted by Dr. Chakŭrski I and colleagues, oral administration of a traditional combination of peppermint, licorice, and fennel exerted a significant activity in reduced spontaneous and palpable pains along the large intestine disappeared and induced daily defecation in the patients with obstipation syndrome.
Further differentiation suggested that the herbal formula demonstrated a potential effect in inhibited the colitis expression in reduced the colon function in reabsorbed fluids and processed waste products from the body and prepared for its elimination.
Some researchers suggested chronic constipation may be an intestinal microbiota imbalance related disease as herbal feed additive including fennel exerted significant effects in digestive disorders of weaning rabbits' intestinal microbiota, according to the study in compared the differences in the composition of the intestinal microbiota in constipated patients and healthy controls.
In fact, further analysis also found that patients with chronic constipation expressed alterations of intestinal microbiota composition characterized by decreased obligate bacteria (e.g. Lactobacillus, Bifidobacterium, and Bacteroides spp.) and a parallel increase of potentially pathogenic microorganisms (e.g. Pseudomonas aeruginosa and Campylobacter jejuni).
Long term imbalance of intestinal microbiota composition may associate with the prevalence of chronic constipation as increased pathogenic microorganisms may reduce intestinal motility and secretory functions by changing the amount of available physiologically active substances and the metabolic environment of the gut in the breakdown of food products into absorbable nutrients.
The above differentiation of the fennel composition effect was supported by an illustration of the study of formula Smooth move, a herbal tea used in some nursing care for residents with chronic constipation.
According to Dr. Bub S and colleagues in a total of 86 nursing home residents with chronic constipation randomly assigned to receive Smooth Move (n = 42) or a placebo (n = 44), once daily, in addition to standard treatment for chronic constipation for 28 days, oral administration of the formula showed a statistically significant increase in the number of bowel movements in compared to placebo group.
More precisely, participants treated with Smooth Move in compared to the nontreatment group experienced an average of 4.14 more bowel movements during the 28-day study period versus the 28-day pre-study period.
Interestingly, in the investigation of the laxative efficacy of composition of Pimpinella anisum L., Foeniculum vulgare Miller, Sambucus nigra L., and Cassia augustifolia used in Brazil for treatment of chronic constipation, researchers at the institution of conducted a randomized, crossover, placebo-controlled, single-blinded trial included 20 patients presenting with chronic constipation according to the criteria of the American Association of Gastroenterology, found that patients received the formula composition exerts a strong improvement of bowel function in compared to control.
However, the application fails to improve the quality of life in participants in reduced some symptoms associated with chronic constipation, except for a small reduction in serum potassium levels during the active treatment.
Dr. Picon PD, the lead author, after taking into account of other confounders, said, "phytotherapic compound assessed has laxative efficacy and is a safe alternative option for the treatment of constipation".
Taken together, fennel used alone or combined with other herbal medicine may be considered as a therapeutic treatment in patients with chronic participation without inducing any intolerable side effects.
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) [Treatment of chronic colitis with an herbal combination of Taraxacum officinale, Hipericum perforatum, Melissa officinaliss, Calendula officinalis and Foeniculumvulgare].[Article in Bulgarian] by Chakŭrski I, Matev M, Koĭchev A, Angelova I, Stefanov G.(PubMed)
(2) Efficacy of an herbal dietary supplement (Smooth Move) in the management of constipation in nursing home residents: A randomized, double-blind, placebo-controlled study by Bub S1, Brinckmann J, Cicconetti G, Valentine B.(PubMed)
(3) Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronicconstipation by Picon PD1, Picon RV, Costa AF, Sander GB, Amaral KM, Aboy AL, Henriques AT.(PubMed)
(4) Intestinal microbiota and chronic constipation by Ying Zhao and Yan-Bo Yu(PubMed)
(5) Performance, digestive disorders and the intestinal microbiota in weaning rabbits are affected by a herbal feed additive by R. Krieg, Wageha Awad, W Vahjen and Wilfried Vahjen(Research gate)
Ginger, The Pungent Spice Which Processes Anti Colon Cancer Potential
Ginger may process certain bioactive compounds with a function to protect our body against the onset of colon cancer, some scientists found.
Colon cancer is a medical condition characterized by cell growth irregularly due to the alternation of DNA.
Most cases of primary colon cancer start in the cell on the surface of the inner lining of the colon. At this stage, most patients do not experience any symptoms and discomfort.
However, at the advanced stage, the cancerous cells in the colon not only can travel a distance far away to infect others healthy tissue and organ but also cause localized severe pain and symptoms as the proliferation of cancer have suppressed the nearby nerve cells and tissue.
Researchers do not know the exact causes of the disease. But they do know a history of polyps, ethnicity, high-fat diet and low fiber, the increase in age, the long-term infection of colon diseases are some of the prevalent risk factors associated with the onset and progression of colon cancer, according to epidemiological studies.
Out of that group of risk factors, the increase in age has been under intensified studies by many scientists.
According to the statistic, colorectal cancer is the third common cancer in the US. The median age at diagnosis for colon cancer is 68 in men and 72 in women.
Early diagnosis of colon cancer can increase the 5 years of survival rate. Truly, in 39% of colon cancer diagnosed at the localized-stage disease, the five and ten years survival rate is 90%.
Dr. Elmer E. van Eeghen, the lead scientist in the cancer program at the Zaans Medisch Centrum, in the concerns of the increase in the age that impact on the development of colon cancer launched an investigation on the influence of age and comorbidity on survival and cause of death in a non-selected population.
In the study "Impact of age and comorbidity on survival in colorectal cancer" wrote, "Patients with colorectal cancer are often excluded from clinical trials based on age or a poor performance score" and " In colon cancer patient age and comorbidity predict survival. This represents possible bias or a reduced survival benefit of treatment, and is an indication that colon cancer is not the prognosis defining illness in the majority of patients".
These results furtherly confirm the prognosis of colon cancer in the aging population. However, most aging population do not develop colon cancer.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The pungent kitchen spice has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural ingredient without side effects for the treatment of colon cancer, researchers at the Universiti Kebangsaan Malaysia, launch an investigation to examine the anti-tumor and anti-inflammation properties of the crude ginger extract against many types of cancer, including colorectal cancer.
The cells used in the experiment were divided into 4 groups: the first group represents HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represents cells treated with ginger and Gelam honey combined.
During the experiment, researchers showed that
* Ginger displays a significant effect in the inhibition of colon cancer cells by blocking the communication of a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell and regulating the cell cycle division.
* Ginger the concentration of the IC50 of 5.2 mg/m simulated the early apoptosis by enhancing the functional proteins associated with the execution of cancer cells and
* Decreasing the expression of proteins associated with cancer cells spreading.
Further differentiation of the anti-proliferative effects of ginger efficacy in enhancing the anti-cancer effects of 5-FU (5-fluorouracil) against a colorectal cancer cell line, HCT 116. researchers showed that ginger (IC50 of 3mg/mL) is more potent than the Gelam honey (IC50 of 75 mg/mL) in inhibiting the growth of HCT 116 cells.
These results once against suggested ginger extract could potentially enhance the chemotherapeutic effect of 5-FU against colorectal cancer.
Additionally ginger in the study of cells divided into 4 groups: the first group represents HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represents cells treated with ginger and Gelam honey combined researcher found that
Taken altogether, the ginger extract used alone or combined with honey might process significant and profound effects in reducing the risk of colon cancer and combined with primary therapy for the treatment of colon cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(2) Gelam honey and ginger potentiate the anti cancer effect of 5-FU against HCT 116 colorectal cancer cells by Hakim L1, Alias E, Makpol S, Ngah WZ, Morad NA, Yusof YA. (PubMed)
(3) Impact of age and comorbidity on survival in colorectal cancer by Elmer E. van Eeghen, Sandra D. Bakker, Aart van Bochove, and Ruud J. L. F. Loffeld. (PMC)
Colon cancer is a medical condition characterized by cell growth irregularly due to the alternation of DNA.
Most cases of primary colon cancer start in the cell on the surface of the inner lining of the colon. At this stage, most patients do not experience any symptoms and discomfort.
However, at the advanced stage, the cancerous cells in the colon not only can travel a distance far away to infect others healthy tissue and organ but also cause localized severe pain and symptoms as the proliferation of cancer have suppressed the nearby nerve cells and tissue.
Researchers do not know the exact causes of the disease. But they do know a history of polyps, ethnicity, high-fat diet and low fiber, the increase in age, the long-term infection of colon diseases are some of the prevalent risk factors associated with the onset and progression of colon cancer, according to epidemiological studies.
Out of that group of risk factors, the increase in age has been under intensified studies by many scientists.
According to the statistic, colorectal cancer is the third common cancer in the US. The median age at diagnosis for colon cancer is 68 in men and 72 in women.
Early diagnosis of colon cancer can increase the 5 years of survival rate. Truly, in 39% of colon cancer diagnosed at the localized-stage disease, the five and ten years survival rate is 90%.
Dr. Elmer E. van Eeghen, the lead scientist in the cancer program at the Zaans Medisch Centrum, in the concerns of the increase in the age that impact on the development of colon cancer launched an investigation on the influence of age and comorbidity on survival and cause of death in a non-selected population.
In the study "Impact of age and comorbidity on survival in colorectal cancer" wrote, "Patients with colorectal cancer are often excluded from clinical trials based on age or a poor performance score" and " In colon cancer patient age and comorbidity predict survival. This represents possible bias or a reduced survival benefit of treatment, and is an indication that colon cancer is not the prognosis defining illness in the majority of patients".
These results furtherly confirm the prognosis of colon cancer in the aging population. However, most aging population do not develop colon cancer.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The pungent kitchen spice has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural ingredient without side effects for the treatment of colon cancer, researchers at the Universiti Kebangsaan Malaysia, launch an investigation to examine the anti-tumor and anti-inflammation properties of the crude ginger extract against many types of cancer, including colorectal cancer.
The cells used in the experiment were divided into 4 groups: the first group represents HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represents cells treated with ginger and Gelam honey combined.
During the experiment, researchers showed that
* Ginger displays a significant effect in the inhibition of colon cancer cells by blocking the communication of a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell and regulating the cell cycle division.
* Ginger the concentration of the IC50 of 5.2 mg/m simulated the early apoptosis by enhancing the functional proteins associated with the execution of cancer cells and
* Decreasing the expression of proteins associated with cancer cells spreading.
Further differentiation of the anti-proliferative effects of ginger efficacy in enhancing the anti-cancer effects of 5-FU (5-fluorouracil) against a colorectal cancer cell line, HCT 116. researchers showed that ginger (IC50 of 3mg/mL) is more potent than the Gelam honey (IC50 of 75 mg/mL) in inhibiting the growth of HCT 116 cells.
These results once against suggested ginger extract could potentially enhance the chemotherapeutic effect of 5-FU against colorectal cancer.
Additionally ginger in the study of cells divided into 4 groups: the first group represents HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represents cells treated with ginger and Gelam honey combined researcher found that
Taken altogether, the ginger extract used alone or combined with honey might process significant and profound effects in reducing the risk of colon cancer and combined with primary therapy for the treatment of colon cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(2) Gelam honey and ginger potentiate the anti cancer effect of 5-FU against HCT 116 colorectal cancer cells by Hakim L1, Alias E, Makpol S, Ngah WZ, Morad NA, Yusof YA. (PubMed)
(3) Impact of age and comorbidity on survival in colorectal cancer by Elmer E. van Eeghen, Sandra D. Bakker, Aart van Bochove, and Ruud J. L. F. Loffeld. (PMC)
Thursday, December 12, 2019
Chaste tree berry (Vitex agnus-castus) on Menopausal symptoms
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb. It is considered as a Queen herb in treating menstrual problems and discomforts by taking it in a prolonged period of time. There was a report that chaste tree berry stems and leaves were used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria,
Chemical constituents
1. β-citronellol
2. Labdane-type diterpenoids,
3. Halimane-type diterpenoid,
4. Oleanane-type triterpenoids,
5. Ursane-type triterpenoids,
6. Sesquiterpenoid,
7. Flavonoid
8. Viteagnusins C, D, E, F, G, and H
9. Abietane-type diterpenoids
Menopause is defined as a condition in which a woman is in the transition stage of permanent cessation of the ovaries functions in egg production because of less production of estrogen and progesterone, signaling the end of the reproductive phase a woman's life. In menopause, menstruation has become irregular and slowly stop overtime, but in some women, menstrual flow comes to a sudden halt.
In a self-administered questionnaire, containing 15 questions, sent to all gynecologists in private practice in Germany to evaluate the complementary and alternative medicine (CAM) in the treatment of climacteric disorders, 98% of the returnees are experienced with therapies of black cohosh (Cimicifuga racemosa), chaste tree (Vitex agnus castus) and St. John's wort(1).
According to the 1Royal Melbourne Institute of Technology (RMIT) University, Bundoora, although evidence from rigorous randomized controlled trials is lacking for the individual herb emerging pharmacological evidence supports a role for V. agnus-castus in the alleviation of menopausal symptoms(2).
Dr. Chopin Lucks B. in the trial of two essential oils (derived separately from leaf and fruit) of Vitex agnus castus indicated that both essential oils show a strong symptomatic relief of common menopausal symptoms(3).
Unfortunately, according to the University Hospital Hamburg-Eppendorf, Agnus castus showed no significant difference in the treatment of climacteric complaints(4) with a combination of Hypericum perforatum (St. John's wort) and Vitex agnus-castus (Chaste tree/berry) also showed the same(5).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) The value of complementary and alternative medicine in the treatment of climacteric symptoms: results of a survey among German gynecologists by von Studnitz FS1, Eulenburg C, Mueck AO, Buhling KJ.(PubMed)
(2) Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints by van Die MD1, Burger HG, Teede HJ, Bone KM.(PubMed)
(3) Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwifery 8 (2003) 148-154] by Chopin Lucks B.(PubMed)
(4) Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnuscastus in the treatment of climacteric complaints: a systematic review by Laakmann E1, Grajecki D, Doege K, zu Eulenburg C, Buhling KJ.(PubMed)
(5) Hypericum perforatum with Vitex agnus-castus in menopausalsymptoms: a randomized, controlled trial by van Die MD1, Burger HG, Bone KM, Cohen MM, Teede HJ.(PubMed)
Chemical constituents
1. β-citronellol
2. Labdane-type diterpenoids,
3. Halimane-type diterpenoid,
4. Oleanane-type triterpenoids,
5. Ursane-type triterpenoids,
6. Sesquiterpenoid,
7. Flavonoid
8. Viteagnusins C, D, E, F, G, and H
9. Abietane-type diterpenoids
Menopause is defined as a condition in which a woman is in the transition stage of permanent cessation of the ovaries functions in egg production because of less production of estrogen and progesterone, signaling the end of the reproductive phase a woman's life. In menopause, menstruation has become irregular and slowly stop overtime, but in some women, menstrual flow comes to a sudden halt.
In a self-administered questionnaire, containing 15 questions, sent to all gynecologists in private practice in Germany to evaluate the complementary and alternative medicine (CAM) in the treatment of climacteric disorders, 98% of the returnees are experienced with therapies of black cohosh (Cimicifuga racemosa), chaste tree (Vitex agnus castus) and St. John's wort(1).
According to the 1Royal Melbourne Institute of Technology (RMIT) University, Bundoora, although evidence from rigorous randomized controlled trials is lacking for the individual herb emerging pharmacological evidence supports a role for V. agnus-castus in the alleviation of menopausal symptoms(2).
Dr. Chopin Lucks B. in the trial of two essential oils (derived separately from leaf and fruit) of Vitex agnus castus indicated that both essential oils show a strong symptomatic relief of common menopausal symptoms(3).
Unfortunately, according to the University Hospital Hamburg-Eppendorf, Agnus castus showed no significant difference in the treatment of climacteric complaints(4) with a combination of Hypericum perforatum (St. John's wort) and Vitex agnus-castus (Chaste tree/berry) also showed the same(5).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) The value of complementary and alternative medicine in the treatment of climacteric symptoms: results of a survey among German gynecologists by von Studnitz FS1, Eulenburg C, Mueck AO, Buhling KJ.(PubMed)
(2) Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints by van Die MD1, Burger HG, Teede HJ, Bone KM.(PubMed)
(3) Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwifery 8 (2003) 148-154] by Chopin Lucks B.(PubMed)
(4) Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnuscastus in the treatment of climacteric complaints: a systematic review by Laakmann E1, Grajecki D, Doege K, zu Eulenburg C, Buhling KJ.(PubMed)
(5) Hypericum perforatum with Vitex agnus-castus in menopausalsymptoms: a randomized, controlled trial by van Die MD1, Burger HG, Bone KM, Cohen MM, Teede HJ.(PubMed)
Cranberry Kills Ovarian Cancer Cells In Vitro
The ovaries formed part of the female reproductive system are the oval-shaped ovum that connects to the fallopian tubes and attaches to the outer layer of the uterus via the ovarian ligament.
Normally, the left and right ovary take a turn to release an egg every month. The ovaries also play a critical role in the production of estrogen and progesterone in the regulation of the process of women menstrual cycle including the release of an egg that migrates down the fallopian tube.
The most common disease associated with ovary dysfunction is polycystic ovary syndrome (PCOS), a hormonal disorder among women of reproductive age.
Ovarian cancer is a chronic and medical condition characterized by abnormal cells growth of ovarian cells which start on the surface of the inner lining of the ovarian tissue. Over time, after penetrating into deeper layers in the ovary, the cancer cell may travel a distance away to infect other nearby healthy tissues or organs, causing secondary metastasis.
Ovarian cancer is one of the most common cancers in the US. According to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, approximately 21,880 women in the United States were diagnosed with ovarian cancer. In the same year, ovarian cancer also causes the death of 13,850 American women.
The exact causes of ovarian cancer are not identified. However, epidemiologically, aging, genetic preposition, race, never pregnant women, family history, long-term chemical exposure, and menopausal hormone therapy MHT are some prevalent factors found in patients with the disease.
Dr. Prof. Rod Baber wrote, "Increased risk persisted after stopping the treatment for some years among women who had used MHT for more than 5 years".
And, "Overall, this increased risk was similar for European and North American perspective studies and for both estrogen-only and estrogen plus progestogen preparations but differed across the subtypes of epithelial ovarian cancers, being increased only in serious and endometrioid subtypes and decreased in mucinous and clear cell subtypes".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of ovarian cancer researchers examined the effect of cranberry flavonoids (flavonols and flavan-3-ols) SKOV-3 and OVCAR-8 ovarian cancer.
According to the tested assays, treatment with quercetin aglycone and PAC DP-9 from the cranberry flavonoids exhibited the strongest activity that induces apoptosis compared to other bioactive compounds.
The combination also inhibited the caspase-3 activation and PARP deactivation associated with apoptosis and increased the cisplatin sensitivity against the tested cell lines.
In SKOV-3 cells, PAC DP-9 also reduced the expression and activation of the epidermal growth factor receptor (EGFR) associated with cancer cell differentiation and proliferation.
Furthermore, quercetin aglycone and PAC DP-9 deactivated MAPK-ERK pathway and the overexpression of proteins associated with the promotion of cancer cell growth.
Moreover, the combination also promotes the gene expression of cancer suppression and arrested cell cycle progression.
Based on the findings, researchers said, "Overall, this study demonstrates promising in vitro cytotoxic and anti-proliferative properties of two newly characterized cranberry flavonoids, quercetin aglycone, and PAC DP-9, against ovarian cancer cells".
Taken altogether, cranberry processed abundantly quercetin aglycone and PAC DP-9 may be considered a remedy for the prevention and treatment of ovarian cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells by Wang Y1, Han A2, Chen E2, Singh RK2, Chichester CO3, Moore RG2, Singh AP1, Vorsa N. (PubMed)
(2) Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells by Kim KK1, Singh AP, Singh RK, Demartino A, Brard L, Vorsa N, Lange TS, Moore RG. (PubMed)
(3) Menopausal hormone therapy and ovarian cancer by Prof. Rod Baber. (PMC)
Normally, the left and right ovary take a turn to release an egg every month. The ovaries also play a critical role in the production of estrogen and progesterone in the regulation of the process of women menstrual cycle including the release of an egg that migrates down the fallopian tube.
The most common disease associated with ovary dysfunction is polycystic ovary syndrome (PCOS), a hormonal disorder among women of reproductive age.
Ovarian cancer is a chronic and medical condition characterized by abnormal cells growth of ovarian cells which start on the surface of the inner lining of the ovarian tissue. Over time, after penetrating into deeper layers in the ovary, the cancer cell may travel a distance away to infect other nearby healthy tissues or organs, causing secondary metastasis.
Ovarian cancer is one of the most common cancers in the US. According to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, approximately 21,880 women in the United States were diagnosed with ovarian cancer. In the same year, ovarian cancer also causes the death of 13,850 American women.
The exact causes of ovarian cancer are not identified. However, epidemiologically, aging, genetic preposition, race, never pregnant women, family history, long-term chemical exposure, and menopausal hormone therapy MHT are some prevalent factors found in patients with the disease.
Dr. Prof. Rod Baber wrote, "Increased risk persisted after stopping the treatment for some years among women who had used MHT for more than 5 years".
And, "Overall, this increased risk was similar for European and North American perspective studies and for both estrogen-only and estrogen plus progestogen preparations but differed across the subtypes of epithelial ovarian cancers, being increased only in serious and endometrioid subtypes and decreased in mucinous and clear cell subtypes".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of ovarian cancer researchers examined the effect of cranberry flavonoids (flavonols and flavan-3-ols) SKOV-3 and OVCAR-8 ovarian cancer.
According to the tested assays, treatment with quercetin aglycone and PAC DP-9 from the cranberry flavonoids exhibited the strongest activity that induces apoptosis compared to other bioactive compounds.
The combination also inhibited the caspase-3 activation and PARP deactivation associated with apoptosis and increased the cisplatin sensitivity against the tested cell lines.
In SKOV-3 cells, PAC DP-9 also reduced the expression and activation of the epidermal growth factor receptor (EGFR) associated with cancer cell differentiation and proliferation.
Furthermore, quercetin aglycone and PAC DP-9 deactivated MAPK-ERK pathway and the overexpression of proteins associated with the promotion of cancer cell growth.
Moreover, the combination also promotes the gene expression of cancer suppression and arrested cell cycle progression.
Based on the findings, researchers said, "Overall, this study demonstrates promising in vitro cytotoxic and anti-proliferative properties of two newly characterized cranberry flavonoids, quercetin aglycone, and PAC DP-9, against ovarian cancer cells".
Taken altogether, cranberry processed abundantly quercetin aglycone and PAC DP-9 may be considered a remedy for the prevention and treatment of ovarian cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells by Wang Y1, Han A2, Chen E2, Singh RK2, Chichester CO3, Moore RG2, Singh AP1, Vorsa N. (PubMed)
(2) Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells by Kim KK1, Singh AP, Singh RK, Demartino A, Brard L, Vorsa N, Lange TS, Moore RG. (PubMed)
(3) Menopausal hormone therapy and ovarian cancer by Prof. Rod Baber. (PMC)
Fennel and its Bioactive Anehtole in Attenuated Risk, Progression and Treatment of Periodontitis (PD)
Fennel may have a therapeutic effect in reduced risk, progression and treatment of periodontitis, some scientists suggested.
Periodontitis (PD) is a dental condition characterized by inflammation of the tissue around the teeth, resulted in shrinkage of the gums and loosening of the teeth if untreated.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
In the investigation of bacterial Escherichia coli lipopolysaccharide (LPS, 30 µg) injected bilaterally into the palatal gingiva (3 µL/site) between the upper first and second molars every two days for 10 days in anesthetized rats, researchers found that application of trans-anethole, a bioactive found in fennel or ketoprofen (10 mg/Kg, i.p.) started 20 minutes before LPS injection and continued for 10 days, exert a significant activity in decreased bacterial infection in induced symptoms of swelling, redness, pain,...
Further analysis suggested that both injections display significantly suppressed levels of interleukin 1 beta (IL-1β), a cytokine with function in regulation of immune and inflammatory responses to infections or sterile insults and tumor necrosis factor-alpha (TNF-α ), a cell-signaling protein involved in systemic inflammation in the acute phase of infection, in compared to Escherichia coli lipopolysaccharide treated rats group.
Moreover, researchers also indicated that bioactive trans-anethole demonstrates a similar effect to rats group treated with conventional medicine ketoprofen without inducing any side effects.
Also in the examine the continuous investigation of trans-anethole effect in modified periodontitis (PD) through the expression of the voltage-gated L-type Ca2+ channel and KCa2+ channels function, showed that administration of fennel bioactive compound also ameliorated the function of
of LPS in induced inflammatory molecules production by.inhibiting above channels expression.
Trans-anethole also attenuated the levels of substance P, bradykinin, histamine and serotonin in facilitated the production of pro-inflammatory factors such as IL-1β and TNF-α in initiated and progression of periodontitis.
Additionally, in the evaluation of chewing the fennel and cardamom seeds on plaque and salivary pH in 50 patients with periodontitis, aged 18-60 years attending V.S dental College and Hospital randomized into two groups for chewing fennel and cardamom seeds. Salivary pH and plaque PH at baseline and immediately after chewing seeds for 5 minutes and after 10 min researchers indicated that the mean salivary PH scores at baseline, immediately and 10 minutes after chewing fennel seeds was 7.1, 7,3 and 7.5 and the mean salivary PH scores at baseline, immediately and 10 minutes after chewing cardamom seeds was 7.4 , 7.6, 7.76, in compared to the mean values of salivary PH scores at baseline, immediately and 10 minutes after chewing cardamom seeds was 7.4, 7.6, 7.76 and the mean plaque pH scores at baseline, immediately and 10 min after chewing fennel seeds was 7.4, 7.55, 7.53.
These findings suggested that chewing both fennel seeds and cardamom seeds are equally effective in increasing salivary and plaque pH.
Dr. Priti Basgauda Patil and colleagues said, "saliva, as a mirror of oral and systemic health, is a valuable source for clinically relevant information because it contains biomarkers specific for the unique physiologic aspects of periodontal diseases".
Increased salivary reduced levels of total free sialic acid are associated with a decreased risk of periodontitis initiation.
Long term expression of low plaque pH is also associated with loss of mineral from the tooth, one of many factors in increased periodontitis risk.
These results postulated an important role of chewing the seeds can be used to lubricate and moisten the mouth, while at the same time providing caries protection to highly susceptible individuals with periodontitis (PD).
The evidence suggests that fennel and its bioactive anethole may have a potent inhibitory effect in reduced risk, progression and treatment of PD through suppression of pro-inflammatory molecules. However, the ingestion of supplements should be taken with to avoid overdose in precipitated acute liver toxicity.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Anethole, a Medicinal Plant Compound, Decreases the Production of Pro-Inflammatory TNF-α and IL-1β in a Rat Model of LPS-Induced Periodontitis byJanet Moradi,a Fatemeh Abbasipour,a,b,* Jalal Zaringhalam,c Bita Maleki,a Narges Ziaee,a Amin Khodadoustan,d and Mahyar Janahmadic(PMC)
(2) EFFECT OF CHEWING FENNEL AND CARDAMOM SEEDS ON DENTAL PLAQUE AND SALIVARY pH – A RANDOMIZED CONTROLLED TRIAL bySwathi V., R. Rekha, Abhishek Jha, G. Radha, S. K. Pallavi and Gadde Praveen(INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH)
(3) Saliva: A diagnostic biomarker of periodontal diseases by Priti Basgauda Patil and Basgauda Ramesh Patil(PMC)
Periodontitis (PD) is a dental condition characterized by inflammation of the tissue around the teeth, resulted in shrinkage of the gums and loosening of the teeth if untreated.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
In the investigation of bacterial Escherichia coli lipopolysaccharide (LPS, 30 µg) injected bilaterally into the palatal gingiva (3 µL/site) between the upper first and second molars every two days for 10 days in anesthetized rats, researchers found that application of trans-anethole, a bioactive found in fennel or ketoprofen (10 mg/Kg, i.p.) started 20 minutes before LPS injection and continued for 10 days, exert a significant activity in decreased bacterial infection in induced symptoms of swelling, redness, pain,...
Further analysis suggested that both injections display significantly suppressed levels of interleukin 1 beta (IL-1β), a cytokine with function in regulation of immune and inflammatory responses to infections or sterile insults and tumor necrosis factor-alpha (TNF-α ), a cell-signaling protein involved in systemic inflammation in the acute phase of infection, in compared to Escherichia coli lipopolysaccharide treated rats group.
Moreover, researchers also indicated that bioactive trans-anethole demonstrates a similar effect to rats group treated with conventional medicine ketoprofen without inducing any side effects.
Also in the examine the continuous investigation of trans-anethole effect in modified periodontitis (PD) through the expression of the voltage-gated L-type Ca2+ channel and KCa2+ channels function, showed that administration of fennel bioactive compound also ameliorated the function of
of LPS in induced inflammatory molecules production by.inhibiting above channels expression.
Trans-anethole also attenuated the levels of substance P, bradykinin, histamine and serotonin in facilitated the production of pro-inflammatory factors such as IL-1β and TNF-α in initiated and progression of periodontitis.
Additionally, in the evaluation of chewing the fennel and cardamom seeds on plaque and salivary pH in 50 patients with periodontitis, aged 18-60 years attending V.S dental College and Hospital randomized into two groups for chewing fennel and cardamom seeds. Salivary pH and plaque PH at baseline and immediately after chewing seeds for 5 minutes and after 10 min researchers indicated that the mean salivary PH scores at baseline, immediately and 10 minutes after chewing fennel seeds was 7.1, 7,3 and 7.5 and the mean salivary PH scores at baseline, immediately and 10 minutes after chewing cardamom seeds was 7.4 , 7.6, 7.76, in compared to the mean values of salivary PH scores at baseline, immediately and 10 minutes after chewing cardamom seeds was 7.4, 7.6, 7.76 and the mean plaque pH scores at baseline, immediately and 10 min after chewing fennel seeds was 7.4, 7.55, 7.53.
These findings suggested that chewing both fennel seeds and cardamom seeds are equally effective in increasing salivary and plaque pH.
Dr. Priti Basgauda Patil and colleagues said, "saliva, as a mirror of oral and systemic health, is a valuable source for clinically relevant information because it contains biomarkers specific for the unique physiologic aspects of periodontal diseases".
Increased salivary reduced levels of total free sialic acid are associated with a decreased risk of periodontitis initiation.
Long term expression of low plaque pH is also associated with loss of mineral from the tooth, one of many factors in increased periodontitis risk.
These results postulated an important role of chewing the seeds can be used to lubricate and moisten the mouth, while at the same time providing caries protection to highly susceptible individuals with periodontitis (PD).
The evidence suggests that fennel and its bioactive anethole may have a potent inhibitory effect in reduced risk, progression and treatment of PD through suppression of pro-inflammatory molecules. However, the ingestion of supplements should be taken with to avoid overdose in precipitated acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Anethole, a Medicinal Plant Compound, Decreases the Production of Pro-Inflammatory TNF-α and IL-1β in a Rat Model of LPS-Induced Periodontitis byJanet Moradi,a Fatemeh Abbasipour,a,b,* Jalal Zaringhalam,c Bita Maleki,a Narges Ziaee,a Amin Khodadoustan,d and Mahyar Janahmadic(PMC)
(2) EFFECT OF CHEWING FENNEL AND CARDAMOM SEEDS ON DENTAL PLAQUE AND SALIVARY pH – A RANDOMIZED CONTROLLED TRIAL bySwathi V., R. Rekha, Abhishek Jha, G. Radha, S. K. Pallavi and Gadde Praveen(INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH)
(3) Saliva: A diagnostic biomarker of periodontal diseases by Priti Basgauda Patil and Basgauda Ramesh Patil(PMC)
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