Aloe Vera, The Immunomodulatory Whole Food Medicine

Aloe Vera may be used as potential herbal medicine in enhanced immune function in promoted immunostimulatory and immunomodulatory expression.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan, used in herbal medicine in treating various diseases, including wound, burn to heal, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

The immunomodulatory effect is an action involved regulation of the immune system against the invasion of foreign subjects in promoted infection and inflammation.

According to the joint study led by the Sahlgrenska Academy at the University of Gothenburg, orally administrated (AVH200®), an aloe vera extract modified the protein involved activation, proliferation and cytokine secretion of healthy human blood T cells, in a dose-dependent manner.


Aloe-emodin(AE), a major constituent found in Aloe Vera exerted a positive effect in significantly enhanced dabrafenib (a BARF inhibitor) antiproliferative activity of mutant cell lines through immunomodulatory activity

The study also confirmed that AE possesses remarkable antineoplastic properties of the drug(dabrafenib) used in the treatment of metastatic colon cancer, against melanoma cells.



In candida Albicans, A. vera extract and its fractions on infected macrophages demonstrated an antifungal effect through activated and modulated the immune response.

Furthermore, the extract also significantly increased the cell viability of macrophages, in comparison with the control group.

Additionally, a polysaccharide isolated from Aloe Vera explicitly also enhanced immune function in producing specific antibody and inducing delayed hypersensitivity in mice model.

Collectively, chemical constituents found in Aloe vera have shown to exhibit immunomodulatory effects in regulated immune function against foreign invasion and allergic reactions and irregular cell growth, but further studies are necessary to confirm this validation.




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Sources
(1) Effects of Aloe barbadensis Mill. extract (AVH200®) on human blood T cell activity in vitro by Ahluwalia B1, Magnusson MK2, Isaksson S3, Larsson F4, Öhman L5.(PubMed)
(2) Aloe-emodin exerts a potent anticancer and immunomodulatory activity on BRAF-mutated human melanoma cells by Tabolacci C1, Cordella M2, Turcano L3, Rossi S2, Lentini A3, Mariotti S4, Nisini R4, Sette G5, Eramo A2, Piredda L3, De Maria R5, Facchiano F6, Beninati S3.(PubMed)
(3) Immunomodulatory effects of Aloe vera and its fractions on response of macrophages against Candida albicans by Farahnejad Z1, Ghazanfari T, Yaraee R(PubMed)
(4) An anti-complementary polysaccharide with immunological adjuvant activity from the leaf parenchyma gel of Aloe vera by t'Hart LA, van den Berg AJ, Kuis L, van Dijk H, Labadie RP.(PubMed)