A chronic wound is a wound that does not heal within a predictable period of time.
It may be a result of the interruption of the stage of wound healing or damage of the blood vessels that have a function in providing necessary conditions to promote the closure of the wound as seen in a diabetic leg ulcer.
In other words, any wound that does not heal with 3 months is considered a chronic wound.
According to the statistics provided by the study "An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds", approximately, 2% of the population in developed countries suffer from chronic wounds.
Additionally, every year, more than 305 million cases of acute, traumatic and burn wounds are treated globally.
Believe it or not, chronic and acute wound affects more than nine times of people around the world compared to those living with cancer.
Some researchers suggested that pressure, trauma and/or lower extremity wounds, increased the bacterial load, interruption of the stage of wound healing including excessive proteases, degraded cell surface structures, and inappropriate treatment are considered the most potent causes of the conditions.
More precisely, if we can protect all stages of wound healing without interruption, the chronic wound can be preventable.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent for the treatment of pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural compound for the treatment of the chronic wound, researchers examined the efficacy of bromelain-based enzymatic debridement of chronic wounds.
The study included 24 patients with chronic wounds of different aetiologies.
According to 2 consecutive single-arm studies assessing the enzymatic debridement efficacy in 2 medical centers, all wounds achieved an average of 68% ± 30% debridement in an average of 3.5 ± 2.8 enzymatic debridement 4-hour sessions.
17/24 patients showed the responding wounds (venous, diabetic, pressure, and post-traumatic aetiologies) of an average of 85% ± 12% debridement in 3.2 ± 2.5 applications, compared to 7/24 patients with no response.
There were no adverse effects reported by the patients. Based on the findings, researchers wrote, "These preliminary results indicate the potential safety and efficacy of bromelain-based enzymatic debridement in chronic wounds".
In vitro, according to the results of two soft tissue healing--fibroblasts and microvascular endothelial cells--were used as mono- and co-culture with bromelain, bromelain attenuated endothelial cell and fibroblast proliferation moderately.
The inhibition of cell proliferation was not associated with cell apoptosis but cell cycle arrest in the G0 phase.
In the comparable tested, bromelain did not reduce endothelial cell migration. whereas fibroblast migration was clearly slowed down.
In other words, bromelain displayed a significant decrease of myofibroblasts under both normoxic (from 19 to 12 %) and hypoxic conditions (from 22 to 15 %) coincident with higher levels of anti-inflammatory expression.
Based on the findings, researchers wrote, "Usage of bromelain as a therapeutic drug for chronic human wounds thus remains a very promising concept for the future".
Taken altogether, bromelain used alone or combined with other remedies may be considered supplements for the prevention and treatment of chronic wounds, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain-based enzymatic debridement of chronic wounds: A preliminary report by Shoham Y1, Krieger Y1, Tamir E2, Silberstein E1, Bogdanov-Berezovsky A1, Haik J3, Rosenberg L. (PubMed)
(2) Bromelain down-regulates myofibroblast differentiation in an in vitro wound healing assay by Aichele K1, Bubel M, Deubel G, Pohlemann T, Oberringer M. (PubMed)
Friday, December 20, 2019
Thursday, December 19, 2019
Aloe Vera, the Neuroprotective Natural Whole Food Medicine
A study from renowned institute suggested that Aloe arborescens may be a potentially neuroprotective
agent against copper-induced neurobehavioral features of Parkinson's disease.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan, used in herbal medicine in treating many kinds of disease, including wound, burn to heal, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.
According to the joint study lead by the Cadi Ayyad University, Neurosciences, Pharmacology and Environment Unit, Aloe Vera expressed altered dopaminergic innervations associated with neurological disorders, Parkinson's disease following Cu intoxication.
Dr. Abbaoui A, the lead researcher said, " (Aloe arborescens gel )AEAAG administration to Cu intoxicated rats showed a noticeable beneficial effect; this potential was featured by a complete recovery of the (tyrosine hydroxylase)TH expression (in the regulation of dopamine Synthesis)
and locomotor behavior deficiencies in the intoxicated rats".
Aloe-emodin, an active compound found in Aloe Vera leaf, also exhibited neuroprotective effects by attenuated scopolamine(a medication used to treat motion sickness and postoperative nausea and vomiting)-induced cognitive deficits via inhibiting acetylcholinesterase (AChE) activity involved breaking down of neurotransmitter and modulating oxidative stress.
The study also insisted the antioxidant activities inhibited significantly extracellular intracellular reactive oxygen species (ROS) production to prevent cytotoxicity in patients with Alzheimer's disease(AD).
In fact, The neuroprotective expression of Aloe Vera polysaccharide is found to downregulate(caspase-3 expression) the process of apoptotic cell death in the brain during injury.
Taking together, Aloe Vera exerted a neuroprotective effect in reduced risk of dementia through many aspects, including free radical inhibition, anti cytotoxicity, chemical toxicity..... but human trials are necessary to confirm its validity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Neuroprotective potential of Aloe arborescens against copper induced neurobehavioral features of Parkinson's disease in rat by Abbaoui A1, Hiba OE2, Gamrani H3.(PubMed)
(2) Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H₂O₂-induced cytotoxicity in PC12 cells by Tao L, Xie J, Wang Y, Wang S, Wu S, Wang Q, Ding H.(PubMed)
(3) Effect of aloe polysaccharide on caspase-3 expression following cerebral ischemia and reperfusion injury in rats by Lu ZQ1, Deng YJ, Lu JX.(PubMed)
agent against copper-induced neurobehavioral features of Parkinson's disease.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan, used in herbal medicine in treating many kinds of disease, including wound, burn to heal, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.
According to the joint study lead by the Cadi Ayyad University, Neurosciences, Pharmacology and Environment Unit, Aloe Vera expressed altered dopaminergic innervations associated with neurological disorders, Parkinson's disease following Cu intoxication.
Dr. Abbaoui A, the lead researcher said, " (Aloe arborescens gel )AEAAG administration to Cu intoxicated rats showed a noticeable beneficial effect; this potential was featured by a complete recovery of the (tyrosine hydroxylase)TH expression (in the regulation of dopamine Synthesis)
and locomotor behavior deficiencies in the intoxicated rats".
Aloe-emodin, an active compound found in Aloe Vera leaf, also exhibited neuroprotective effects by attenuated scopolamine(a medication used to treat motion sickness and postoperative nausea and vomiting)-induced cognitive deficits via inhibiting acetylcholinesterase (AChE) activity involved breaking down of neurotransmitter and modulating oxidative stress.
The study also insisted the antioxidant activities inhibited significantly extracellular intracellular reactive oxygen species (ROS) production to prevent cytotoxicity in patients with Alzheimer's disease(AD).
In fact, The neuroprotective expression of Aloe Vera polysaccharide is found to downregulate(caspase-3 expression) the process of apoptotic cell death in the brain during injury.
Taking together, Aloe Vera exerted a neuroprotective effect in reduced risk of dementia through many aspects, including free radical inhibition, anti cytotoxicity, chemical toxicity..... but human trials are necessary to confirm its validity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Neuroprotective potential of Aloe arborescens against copper induced neurobehavioral features of Parkinson's disease in rat by Abbaoui A1, Hiba OE2, Gamrani H3.(PubMed)
(2) Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H₂O₂-induced cytotoxicity in PC12 cells by Tao L, Xie J, Wang Y, Wang S, Wu S, Wang Q, Ding H.(PubMed)
(3) Effect of aloe polysaccharide on caspase-3 expression following cerebral ischemia and reperfusion injury in rats by Lu ZQ1, Deng YJ, Lu JX.(PubMed)
Garlic - The Whole Food Medicine for Reduced Risk and Treatment of Breast Cancer
Garlic is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there are also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Fresh Garlic Extract beside inhibited colon and gastric cancer in 2 previous articles, it also is found to arrest the growth and alter the morphology of MCF7 breast cancer cells.
Also in MCF7 human breast cancer cells, garlic constituent diallyl trisulfide has highly effective antitumor effects by the suppressing viability of cultured MCF-7 and MCF-12a cells, through decreased the percent of cells in G(2)/M and induced apoptotic cell death.
According to the study by 201 South University Street, diallyl trisulfide, inhibited the expression of MDA-MB-231 and MCF-7 breast cancer cells, regardless to the state of estrogen in the tumors.
In a total of 285 women (aged 25-65 years old) newly diagnosed with histopathologically confirmed breast cancer, dietary Allium Vegetables has a negative association between the consumption of raw onion and the risk of breast cancer.
Dr. Roy N., the lead author at the Kerala Agricultural University, said, "Docking studies and ADMET evaluation revealed twelve compounds (isolated from garlic) to be active against the targets(breast cancer cell lines). All the compounds displayed highly negative dock scores which indicated good interactions".
Therefore, the effectiveness of garlic in reduced risk and treatment of breast cancer is probably due to the existence of many phytochemicals found in the herb. Women who increased intake of garlic every day may see the risk of breast cancer reduced substantially.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Fresh Garlic Extract Induces Growth Arrest and Morphological Differentiation of MCF7 Breast Cancer Cells by Modem S1, Dicarlo SE, Reddy TR.(PubMed)
(2) Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells by Malki A1, El-Saadani M, Sultan AS.(PubMed)
(3) Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells by Kiesel VA1, Stan SD2.(PubMed)
Anise, A Potent Herb for Women Health in All Aspects( Milk Secretion, Promoted Menstruation, Facilitated Birth, Alleviated Symptoms of Climacteric, Increased Libido and More....)
Anise may have a potential and substantial effect in promoted women's health in all aspects, some scientists suggested.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic,...
Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
In the study of Anise estrogenic activity at doses levels of 50 mg, 70 mg and 80 mg/kg po. in rats, researchers found that application of Anise at all dose exerted a strong estrogenic effect without affecting the levels of progestational, anti-progestational, androgenic or anti-androgenic activities and inducing any side effects even at the doses of more than 3000 mg/kg with LD50, an indication of 50% percent of a population of animals killed usually within a certain time due to some application in dose-dependent manner.
Also, in the investigation of the Anise estrogenic effect, researchers found that the application of Anise displayed estrogenic activity through increased milk secretion, promote menstruation, facilitate birth, alleviate the symptoms of the male climacteric, and increase libido.
Further analysis, also suggested that the implication of fennel estrogenic activity was associated to the major bioactive compound anethole found at high levels in the fennel essential oil.
However, even with lesser amount in fennel essential oil, polymers of anethole, the derivative of dianethole and photoanethole are considered as actual pharmacological values in testing for the drug in treatment of extrogenic deficiency related diseases, including menstrual disorder, libido, menopause symptoms, male climacteric,.....
The above differentiation was supported by the evaluation of the estrogenic activity of essential oils of eleven Pimpinella species and the compounds isolated from these species, conducted by the Anadolu University.
According to yeast estrogen screen (YES) assay in the study, Anise essential oils containing (E)-anethole as major compounds showed estrogenic activity, in compared to insignificant expression in aerial parts without fruits of P. anisetum and P. flabellifolia.
At the presence of anethole-containing oils from 30-50%, Anise exerted the maximal response in expression estrogenic activity.
Interestingly, Fruits of P. isaurica and P. peucedanifolia were estrogenic in spite of the absence or trace amount of anethole.
These results suggested that the estrogenic activity of Pimpinella oils may also be contributed by other components other than anethole.
In other words, anethole, a major bioactive compound may not be solely responsible for contributing towards estrogenic activity and essential oil isolated from different parts of the plant and species expressed a varied in estrogenic potencies in compared to 17 beta-estradiol.
In herbal Anise, the fruit oils were most estrogenic followed by the aerial parts without fruits and the root oils and their EC50 values varied from 45 micrograms/mL to 650 micrograms/mL.
Taken together, Anise and its major bioactive compound anethole may be considered as a functional food for reduced risk, progression, and treatment of estrogenic deficiency syndrome and diseases, such as menopause symptoms and women reproductive diseases.
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Fennel and anise as estrogenic agents BY MichaelAlbert-Puleo(Science Direct)
(2) Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, evaluated using a recombinant yeast screen by Tabanca N1, Khan SI, Bedir E, Annavarapu S, Willett K, Khan IA, Kirimer N, Baser KH.(PubMed)
(3) Anti-fertility activity and hormonal profile of trans-anethole in rats by Dhar SK1(PubMed)
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic,...
Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
In the study of Anise estrogenic activity at doses levels of 50 mg, 70 mg and 80 mg/kg po. in rats, researchers found that application of Anise at all dose exerted a strong estrogenic effect without affecting the levels of progestational, anti-progestational, androgenic or anti-androgenic activities and inducing any side effects even at the doses of more than 3000 mg/kg with LD50, an indication of 50% percent of a population of animals killed usually within a certain time due to some application in dose-dependent manner.
Also, in the investigation of the Anise estrogenic effect, researchers found that the application of Anise displayed estrogenic activity through increased milk secretion, promote menstruation, facilitate birth, alleviate the symptoms of the male climacteric, and increase libido.
Further analysis, also suggested that the implication of fennel estrogenic activity was associated to the major bioactive compound anethole found at high levels in the fennel essential oil.
However, even with lesser amount in fennel essential oil, polymers of anethole, the derivative of dianethole and photoanethole are considered as actual pharmacological values in testing for the drug in treatment of extrogenic deficiency related diseases, including menstrual disorder, libido, menopause symptoms, male climacteric,.....
The above differentiation was supported by the evaluation of the estrogenic activity of essential oils of eleven Pimpinella species and the compounds isolated from these species, conducted by the Anadolu University.
According to yeast estrogen screen (YES) assay in the study, Anise essential oils containing (E)-anethole as major compounds showed estrogenic activity, in compared to insignificant expression in aerial parts without fruits of P. anisetum and P. flabellifolia.
At the presence of anethole-containing oils from 30-50%, Anise exerted the maximal response in expression estrogenic activity.
Interestingly, Fruits of P. isaurica and P. peucedanifolia were estrogenic in spite of the absence or trace amount of anethole.
These results suggested that the estrogenic activity of Pimpinella oils may also be contributed by other components other than anethole.
In other words, anethole, a major bioactive compound may not be solely responsible for contributing towards estrogenic activity and essential oil isolated from different parts of the plant and species expressed a varied in estrogenic potencies in compared to 17 beta-estradiol.
In herbal Anise, the fruit oils were most estrogenic followed by the aerial parts without fruits and the root oils and their EC50 values varied from 45 micrograms/mL to 650 micrograms/mL.
Taken together, Anise and its major bioactive compound anethole may be considered as a functional food for reduced risk, progression, and treatment of estrogenic deficiency syndrome and diseases, such as menopause symptoms and women reproductive diseases.
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Fennel and anise as estrogenic agents BY MichaelAlbert-Puleo(Science Direct)
(2) Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, evaluated using a recombinant yeast screen by Tabanca N1, Khan SI, Bedir E, Annavarapu S, Willett K, Khan IA, Kirimer N, Baser KH.(PubMed)
(3) Anti-fertility activity and hormonal profile of trans-anethole in rats by Dhar SK1(PubMed)
Ashwagandha Promotes The Healthy Neurons Activity and Brain Functioning
The brain formed part of the central nervous system is the most complex organ made up of more than billions of nerve cells or neurons.
The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites and an axon, is a cell in the nervous system that carries electrical impulses.
Neurons are core components of the brain, spinal cord and peripheral nerves that play an essential role to process and transmit information.
The function of neurons can be classified into 3 types
* The sensory neurons found within the nervous system that convert external stimuli from the organism's environment into internal electrical impulses. In other words, sensory neurons are activated by sensory input from the environment, including physical input of sound, touch, heat, or light.
* The motor neurons transmit information from the spinal cord to skeletal and smooth muscles,. In other words, motor neurons directly control all of the muscle movements.
* The interneurons connect the motor and sensory neurons. In other words, the interneurons transfer signals between sensory and motor neurons.
Believe it or not, there are more than 600 diseases of the central nervous system, including brain tumors, epilepsy, dementia such as Parkinson's disease and Alzheimer's disease and stroke.
The top 3 of neurological diseases include
* Alzheimer's disease (AD) is a neurodegenerative disease in the elderly, associated with the worsening of memory, thinking and behavior that severe enough to affect language communication, memory, lifelong hobbies or social life
* Bell's Palsy is a condition caused by sudden weakness or paralysis of facial muscles on one side of the face.
* Cerebral Palsy is a neurological disorder of children affecting a child's movement, motor skills, and muscle tone.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of brain health, researchers examined the effects of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components for neuroprotective activities against oxidative stress in cultured glioblastoma and neuroblastoma cells.
According to the tested analysis, the extracts and one of the purified components at a low dose protected the glial and neuronal cells from oxidation, an important activity that promotes the neuron activity.
Furthermore, glutamate insult induced by the oxidative stress was also inhibited by the application of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components.
Based on the findings, researchers said, "the combinations of extracts and active component were highly potent endorsing the therapeutic merit of the combinational approach".
And, "Ashwagandha leaf derived bioactive compounds have neuroprotective potential and may serve as a supplement for brain health.s".
Taken altogether, Ashwagandha may be considered a functional herb for the promotion of brain functioning, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation by Shah N1, Singh R1, Sarangi U1, Saxena N1, Chaudhary A1, Kaur G2, Kaul SC1, Wadhwa R. (PubMed)
(2) Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells by Konar A1, Shah N, Singh R, Saxena N, Kaul SC, Wadhwa R, Thakur MK. (PubMed)
The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites and an axon, is a cell in the nervous system that carries electrical impulses.
Neurons are core components of the brain, spinal cord and peripheral nerves that play an essential role to process and transmit information.
The function of neurons can be classified into 3 types
* The sensory neurons found within the nervous system that convert external stimuli from the organism's environment into internal electrical impulses. In other words, sensory neurons are activated by sensory input from the environment, including physical input of sound, touch, heat, or light.
* The motor neurons transmit information from the spinal cord to skeletal and smooth muscles,. In other words, motor neurons directly control all of the muscle movements.
* The interneurons connect the motor and sensory neurons. In other words, the interneurons transfer signals between sensory and motor neurons.
Believe it or not, there are more than 600 diseases of the central nervous system, including brain tumors, epilepsy, dementia such as Parkinson's disease and Alzheimer's disease and stroke.
The top 3 of neurological diseases include
* Alzheimer's disease (AD) is a neurodegenerative disease in the elderly, associated with the worsening of memory, thinking and behavior that severe enough to affect language communication, memory, lifelong hobbies or social life
* Bell's Palsy is a condition caused by sudden weakness or paralysis of facial muscles on one side of the face.
* Cerebral Palsy is a neurological disorder of children affecting a child's movement, motor skills, and muscle tone.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of brain health, researchers examined the effects of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components for neuroprotective activities against oxidative stress in cultured glioblastoma and neuroblastoma cells.
According to the tested analysis, the extracts and one of the purified components at a low dose protected the glial and neuronal cells from oxidation, an important activity that promotes the neuron activity.
Furthermore, glutamate insult induced by the oxidative stress was also inhibited by the application of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components.
Based on the findings, researchers said, "the combinations of extracts and active component were highly potent endorsing the therapeutic merit of the combinational approach".
And, "Ashwagandha leaf derived bioactive compounds have neuroprotective potential and may serve as a supplement for brain health.s".
Taken altogether, Ashwagandha may be considered a functional herb for the promotion of brain functioning, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation by Shah N1, Singh R1, Sarangi U1, Saxena N1, Chaudhary A1, Kaur G2, Kaul SC1, Wadhwa R. (PubMed)
(2) Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells by Konar A1, Shah N, Singh R, Saxena N, Kaul SC, Wadhwa R, Thakur MK. (PubMed)
Bromelain Suppresses Rheumatoid Arthritis in Vivo
Rheumatoid Arthritis (RA) a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.
The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders(1).
According to CDC, Musculoskeletal disorders (MSDs) affect over 52 million of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2).
Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).
Most common symptoms of RA are
* The feet and joints
Patients with rheumatoid arthritis (RA) often associate with valgus deformities of the feet and gait due to body function in an effort to support the collapsing longitudinal arch of the foot.
* The gait
Rheumatoid arthritis (RA) causes a significant reduction in joint motions, joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range.
* The hands
The effects of the deformation of RA's hands can be described through the defects of bone ankylosis as a result of bone damage to the prolonged onset of the disease(12).
* The Muscle strength
The effects of muscle strength in a patient with RA may contribute to the prevalence of functional limitations physically of that can affect daily living and quality of life.
* Rheumatoid Nodules
Rheumatoid nodules, lump on the skin, closed to the joint have been found to affect the joints of patients with rheumatoid nodules.
* Conjunctival nodule
Although is rare in patients with rheumatoid arthritis, the appearance of the nodules may exhibit the
the severity of the underlying disease.
* Morning stiffness
Morning stiffness, as a marker of inflammatory activity that reflects the functional disability and pain is a very common symptom of patients in early rheumatoid arthritis.
Conventionally, there is no cure for RA. Medication is to relieve symptoms such as pain, slow the progression and improve quality of life, including disease-modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural agent for the treatment of adjuvant rheumatic diseases, researchers examined the anti-inflammatory property of both enzyme therapy and combined therapy with cyclosporin in an animal model.
The study included rats with adjuvant-induced arthritis administered either cyclosporin A (2.5 or 5.0 mg/kg/day per os), a mixture of enzymes (Phlogenzym (PHL); 45 mg/kg twice daily intrarectally), or a combination of 2.5 mg cyclosporin A and 90 mg PHL for a period of 40 days.
According to the tested assays, the combination therapy with cyclosporin A plus PHLshowed a significantly inhibited both the inflammation and destructive arthritis-associated changes, such as serum albumin, changes in hind paw swelling and bone erosions.
Compared to the higher dose, 2.5 mg of cyclosporin A and PHL alone inhibited the disease markers to a lesser extent and a later stage of arthritis development.
In other words, the combination inhibited all parameters associated with the onset of adjuvant rheumatic diseases in a dose-dependent manner.
Based on the findings, researchers wrote, "The results show the inhibitory effect of enzyme therapy on rat adjuvant arthritis, as well as the efficacy of a low dose of cyclosporin A given in combination with enzyme therapy, which may be useful in the treatment of rheumatoid arthritis".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of adjuvant rheumatic diseases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review].
[Article in German] by Heyll U1, Münnich U, Senger V. (PubMed)
(2) Enzyme and combination therapy with cyclosporin A in the rat developing adjuvant arthritis by Rovenská E1, Svík K, Stancíková M, Rovenský J. (PubMed)
(3) Most Common Disease of elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Rheumatoid Arthritis: The Signs and Symptoms by Kyle J. Norton
Wednesday, December 18, 2019
Bilberry Protects the Lung Cells Integrity and Viability Against Lung Cancer, Scientists Say
Bilberry may have a strong effect in reducing the risk and treatment of lung cancer, according to studies.
Lung cancer is a chronic condition characterized by cell growth irregularly and disorderly in the lung tissue.
Most cases of lung cancer caused by the alternation of calls DNA begin in the cells on the surface of the inner lining of the lung.
At the advanced stage, the cancer cell from the lung can travel a distance away to infect other healthy tissue and organs through the circulation of fluid and blood, leading to the secondary metastasis.
According to statistics, in 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Also in 2017, lung cancer caused the death of 21,100 Canadians.
Smoking although it is a major cause of lung cancer, however, not all lung cancer patients with lung cancer are smokers. Nonsmokers' lung cancer may be caused by exposure to radon, secondhand smoke, air pollution, or other factors.
Some researchers suggested that lung cancer in many incidences is associated with oxidative stress as found in advanced lung cancer patients.
Dr. the lead scientist in the examination of the oxidative stress in the risk lung cancer said, "Oxidative stress also plays important roles in the pathogenesis of many diseases, including aging, degenerative disease, and cancer. Among cancers, lung cancer is the leading cause of cancer in the Western world".
And, "Distinct measures of primary and secondary prevention have been investigated to reduce the risk of morbidity and mortality caused by lung cancer. Among them, it seems that physical activity and nutrition have some beneficial effects".
The results clearly suggested that the external sources of dietary antioxidants from the food sources may be helpful in reducing the risk of lung cancer by suppressing the overexpression of free radicals before they can induce oxidative stress.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a replacement for the treatment of lung cancer with no side effects examined the berries' bioactive compound anthocyanidins and its derivative cyanidin, malvidin, peonidin, petunidin, and delphinidin anticancer effects.
A mixture, including blueberry, bilberry and Indian blackberry ('Jamun') was selected to test in two aggressive non-small-cell lung cancer cell lines.
Injection of the mixture exerted a higher induction of cell-cycle arrest, apoptosis, and suppression of NSCLC cell invasion and migration compared to individual anthocyanidins.
According to tested assays, the mixture inhibited lung cancer cells apoptosis by decreasing the expression of the genes associated with cell cycle division and cell survival and proliferation.
Furthermore, the mixture also elevated the protein involved in cancer cell death programming.
Interestingly, in vivo, both the mixture of anthocyanidins from bilberry (0.5mg/mouse) and the most potent anthocyanidin, delphinidin (1.5mg/mouse) significantly inhibited the growth of H1299 xenografts in nude mice by 60%.
Dr. Kausar H and colleagues said, in the final report "Our results thus demonstrate the therapeutic potential of berries rich in this mixture of diverse anthocyanidins for non-small-cell lung cancer treatment and to prevent its future recurrence and metastasis".
In order to reveal more information about bilberry anti-lung cancer activity, researchers assessed the involvement of oxidative stress in lung adenocarcinogenesis, using mice deficient in the 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene and wild-type mice (C57BL6/J origin) administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Where deficiency of 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene was found to associate with the advanced stage of cancer.
On week after induced lung cancer by administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), selected mice were treated with one of 4 antioxidants (phenyl N-tert-butyl nitrone 0.13% in drinking water, resveratrol 20 ppm in the diet, lactoferrin 2% in diet and bilberry powder 2% in diet) or no supplement for 33 weeks.
All antioxidant application demonstrated a strong inhibition against lung adenocarcinogenesis, through modulating the gene expression of gene deficiency such as 8-hydroxyguanine DNA glycosylase 1 (Ogg1) and genes mutation such as Egfr and K-ras.
Taken altogether, bilberry processed abundantly bioactive compounds me be considered a functional remedy for the prevention and treatment of lung cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells by Kausar H1, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh IP, Gupta RC. (PubMed)
(2) Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice by Igarashi M1, Watanabe M, Yoshida M, Sugaya K, Endo Y, Miyajima N, Abe M, Sugano S, Nakae D.(PubMed)
(3) Lung cancer: what are the links with oxidative stress, physical activity and nutrition by Filaire E1, Dupuis C, Galvaing G, Aubreton S, Laurent H, Richard R, Filaire M. (PubMed)
Lung cancer is a chronic condition characterized by cell growth irregularly and disorderly in the lung tissue.
Most cases of lung cancer caused by the alternation of calls DNA begin in the cells on the surface of the inner lining of the lung.
At the advanced stage, the cancer cell from the lung can travel a distance away to infect other healthy tissue and organs through the circulation of fluid and blood, leading to the secondary metastasis.
According to statistics, in 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Also in 2017, lung cancer caused the death of 21,100 Canadians.
Smoking although it is a major cause of lung cancer, however, not all lung cancer patients with lung cancer are smokers. Nonsmokers' lung cancer may be caused by exposure to radon, secondhand smoke, air pollution, or other factors.
Some researchers suggested that lung cancer in many incidences is associated with oxidative stress as found in advanced lung cancer patients.
Dr. the lead scientist in the examination of the oxidative stress in the risk lung cancer said, "Oxidative stress also plays important roles in the pathogenesis of many diseases, including aging, degenerative disease, and cancer. Among cancers, lung cancer is the leading cause of cancer in the Western world".
And, "Distinct measures of primary and secondary prevention have been investigated to reduce the risk of morbidity and mortality caused by lung cancer. Among them, it seems that physical activity and nutrition have some beneficial effects".
The results clearly suggested that the external sources of dietary antioxidants from the food sources may be helpful in reducing the risk of lung cancer by suppressing the overexpression of free radicals before they can induce oxidative stress.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a replacement for the treatment of lung cancer with no side effects examined the berries' bioactive compound anthocyanidins and its derivative cyanidin, malvidin, peonidin, petunidin, and delphinidin anticancer effects.
A mixture, including blueberry, bilberry and Indian blackberry ('Jamun') was selected to test in two aggressive non-small-cell lung cancer cell lines.
Injection of the mixture exerted a higher induction of cell-cycle arrest, apoptosis, and suppression of NSCLC cell invasion and migration compared to individual anthocyanidins.
According to tested assays, the mixture inhibited lung cancer cells apoptosis by decreasing the expression of the genes associated with cell cycle division and cell survival and proliferation.
Furthermore, the mixture also elevated the protein involved in cancer cell death programming.
Interestingly, in vivo, both the mixture of anthocyanidins from bilberry (0.5mg/mouse) and the most potent anthocyanidin, delphinidin (1.5mg/mouse) significantly inhibited the growth of H1299 xenografts in nude mice by 60%.
Dr. Kausar H and colleagues said, in the final report "Our results thus demonstrate the therapeutic potential of berries rich in this mixture of diverse anthocyanidins for non-small-cell lung cancer treatment and to prevent its future recurrence and metastasis".
In order to reveal more information about bilberry anti-lung cancer activity, researchers assessed the involvement of oxidative stress in lung adenocarcinogenesis, using mice deficient in the 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene and wild-type mice (C57BL6/J origin) administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Where deficiency of 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene was found to associate with the advanced stage of cancer.
On week after induced lung cancer by administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), selected mice were treated with one of 4 antioxidants (phenyl N-tert-butyl nitrone 0.13% in drinking water, resveratrol 20 ppm in the diet, lactoferrin 2% in diet and bilberry powder 2% in diet) or no supplement for 33 weeks.
All antioxidant application demonstrated a strong inhibition against lung adenocarcinogenesis, through modulating the gene expression of gene deficiency such as 8-hydroxyguanine DNA glycosylase 1 (Ogg1) and genes mutation such as Egfr and K-ras.
Taken altogether, bilberry processed abundantly bioactive compounds me be considered a functional remedy for the prevention and treatment of lung cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells by Kausar H1, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh IP, Gupta RC. (PubMed)
(2) Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice by Igarashi M1, Watanabe M, Yoshida M, Sugaya K, Endo Y, Miyajima N, Abe M, Sugano S, Nakae D.(PubMed)
(3) Lung cancer: what are the links with oxidative stress, physical activity and nutrition by Filaire E1, Dupuis C, Galvaing G, Aubreton S, Laurent H, Richard R, Filaire M. (PubMed)
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