Aloe Vera, the Neuroprotective Natural Whole Food Medicine

A study from renowned institute suggested that Aloe arborescens may be a potentially neuroprotective
agent against copper-induced neurobehavioral features of Parkinson's disease.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan, used in herbal medicine in treating many kinds of disease, including wound, burn to heal, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

According to the joint study lead by the Cadi Ayyad University, Neurosciences, Pharmacology and Environment Unit, Aloe Vera expressed altered dopaminergic innervations associated with neurological disorders, Parkinson's disease following Cu intoxication.

Dr. Abbaoui A, the lead researcher said, " (Aloe arborescens gel )AEAAG administration to Cu intoxicated rats showed a noticeable beneficial effect; this potential was featured by a complete recovery of the (tyrosine hydroxylase)TH expression (in the regulation of dopamine Synthesis)
and locomotor behavior deficiencies in the intoxicated rats".


Aloe-emodin, an active compound found in Aloe Vera leaf, also exhibited neuroprotective effects by attenuated scopolamine(a medication used to treat motion sickness and postoperative nausea and vomiting)-induced cognitive deficits via inhibiting acetylcholinesterase (AChE) activity involved breaking down of neurotransmitter and modulating oxidative stress.

The study also insisted the antioxidant activities inhibited significantly extracellular intracellular reactive oxygen species (ROS) production to prevent cytotoxicity in patients with Alzheimer's disease(AD).

In fact, The neuroprotective expression of Aloe Vera polysaccharide is found to downregulate(caspase-3 expression) the process of apoptotic cell death in the brain during injury.

Taking together, Aloe Vera exerted a neuroprotective effect in reduced risk of dementia through many aspects, including free radical inhibition, anti cytotoxicity, chemical toxicity..... but human trials are necessary to confirm its validity.


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Sources
(1) Neuroprotective potential of Aloe arborescens against copper induced neurobehavioral features of Parkinson's disease in rat by Abbaoui A1, Hiba OE2, Gamrani H3.(PubMed)
(2) Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H₂O₂-induced cytotoxicity in PC12 cells by Tao L, Xie J, Wang Y, Wang S, Wu S, Wang Q, Ding H.(PubMed)
(3) Effect of aloe polysaccharide on caspase-3 expression following cerebral ischemia and reperfusion injury in rats by Lu ZQ1, Deng YJ, Lu JX.(PubMed)