Herbal Cascara Sagrada may have a potential and positive effect in reducing risks and treatment of constipation, according to studies.
Constipation is a condition of infrequent bowel movements caused by hard and dry stool.
Without bowel movement that lasts longer than 3 days is considered having a condition of constipation
Chronic constipation can lead to symptoms of abdominal pain, bloating, and feeling as if one has not completely passed the bowel movement.
In severe cases, chronic constipation can cause the complications of formation of hemorrhoids, anal fissure or fecal impaction.
According to the statistic, constipation most often affects women, adults ages 65 and older. Constipation is highly prevalent, with approximately 12 million general practitioner prescriptions for laxatives in England in 2001.
Most common risk factors for the onset of the condition including, a poor diet with less fiber, overuse of laxatives, certain medical conditions such as irritable bowel syndrome, colon cancer, long-term use of certain medications, such as narcotics, antidepressants and resisting the urge to poop.
Some researchers suggested that atypical defecation habits are one of the most risk factors associated with the risk of constipation that is harder to treat.
Ms. Isabelle Beaudry-Bellefeuille in the examine the risk chronic constipation with atypical defecation habits in children, wrote, "Atypical defecation habits are common and distressing for children and families and can have a major impact on the quality of life. Often, no underlying factor can be identified, and the defecation disorder is considered functional".
And, "Current interventions are not successful for up to 50% of children. We suggest this high failure rate may be caused by a lack of consistency in the descriptors of behavioral indicators for functional defecation problems. Most investigations and descriptors focus on general behavior. There are fewer reports concerning defecation-specific behaviors".
More investigations are necessary before a strategy can be found for the treatment of chronic constipation with atypical defecation habits in children.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America. The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers in the concerns of the high prevalence of constipation used of laxatives, a colon addictive substance, examined the effects of cascara sagrada accompanied by the infection of ear mushrooms.
A total of 34 patients diagnosed with functional constipation according to the definition of the modified Rome II criteria. divided into 3 groups (placebo, ear mushrooms alone, and ear mushrooms with additives including cascara sagrada, etc.).
Numbers of bowel movement, straining, sense of incomplete evacuation, stool consistency, satisfactory relief, abdominal pain/discomfort and colon transit time were evaluated and analyzed before, during and after the treatment.
Both ear mushrooms alone and ear mushrooms with additives significantly improved a number of bowel movements, straining, sense of incomplete evacuation.
Furthermore, both applications also improved stool consistency and satisfactory relief in the participants.
Compared to the use of ear mushrooms alone, adding herbal Cascara Sagrada was found to be more effective in the improvement of constipation.
However, compared to no side effects on the use of ear mushrooms, adding herbal Cascara Sagrada may induce mild gastrointestinal discomforts in some patients.
The results clearly suggested that ear mushrooms combined with herbal Cascara Sagrada and fiber may have a strong inhibition against the development and chronic constipation with no serious effects.
Taken altogether, herbal Cascara Sagrada may be used alone or combined with other anti-constipation functional foods for the prevention and treatment of chronic constipation with little or no side effects.
However, due to the limitation of the small sample size, we suggested that the confirmation by a large sample and multicenter human study is necessary before declaring the effective use of herbal Cascara Sagrada and its combination for the treatment of constipation.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Rhamnus purshiana (Cascara)
(2) Constipation in adults. by Mueller-Lissner SA, Wald A.(PubMed)
(3) [Effect of ear mushroom (Auricularia) on functional constipation].[Article in Korean] by Kim TI, Park SJ, Choi CH, Lee SK, Kim WH.(PubMed)
(4) Defecation-Specific Behavior in Children with Functional Defecation Issues: A Systematic Review by Isabelle Beaudry-Bellefeuille, MSc. (PMC)
Thursday, January 2, 2020
Herbal Artichoke Protects Us Against Liver Disease
The liver is the largest organ in the human body besides processing the function in filtering blood from the digestive system before passing them to other parts of the body, it also detoxifies toxic chemicals and metabolizes drugs and secretes bile to assist the digestive function in breaking down food.
Liver protective activity is an action that protects the liver functioning by blocking any substance or pathogens that can cause liver injury or damage.
The exact causes of liver disease are not identified. Researchers do not know why a person is prone to the disease onset while other person does not, even they share a similar health condition and family history
According to the medical literature, there is a perception that liver disease mostly caused by excessive alcohol drinking and viral infection. However, as the time progression, many studies also found that obesity, type 2 diabetes mellitus, dyslipidemia, and metabolic syndrome also play a critical role in developing liver disease.
Some researchers suggested that people with the weakened immune system or immune deficiency are also at an increased risk of liver disease.
Dr. Hadzic N. in the investigation of immune deficiency related liver disease wrote, "It is estimated that around one-quarter of patients with a primary immune deficiency will have some degree of liver involvement".
And, "The most common primary immune deficiencies associated with the liver disease are combined immune deficiency (CID), hyper-IgM syndrome, common variable immunodeficiency, while the commonest liver disease being sclerosing cholangitis"
Most common symptoms of liver disease are jaundice, itchy skin Skin, dark urine color, and pale stool color.
Some patient may also experience symptoms of abdominal pain and swelling, swelling in the legs and ankles and persistent fatigue.
Therefore, if you have some of the aforementioned symptoms, please check with your doctor to rule the possibility.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Searching the list of natural compounds with liver protective activity, researchers examined the effects of artichoke in liver dysfunctions.
The study included the preparation of 4 extract concentrations (0.62, 1.25, 2.5 and 5.0 mg/mL) evaluated on human hepatocyte cultures, HepG2 cells, using the comet assay.
Injection of extract concentrations of 0.62, 1.25 and 2.5 mg/mL, exhibited a significant cytotoxic effect in pretreatment, compared to hydrogen peroxide alone.
However, in simultaneous and post-treatment protocols, only the lowest concentration of artichoke inhibited the frequency of DNA damage caused by hydrogen peroxide.
At highest concentration at 2.5 mg/mL, artichoke extract increased hydrogen peroxide genotoxicity against HepG2 cells.
These results suggested that artichoke leaves aqueous extract induced genotoxic effects in a concentration higher than .62 mg/mL in the tested cell line.
In other words, artichoke extract protects the liver against overexpression of free radicals in the initiation of liver cell damage in a dose-dependent manner.
Dr. da Silva RP, the lead scientist said, "artichoke is genotoxic, in vitro, to HepG2 cells, but can also modulate hydrogen peroxide DNA damage".
In order to reveal more information about artichoke liver protective effects, researchers examined the herbal effects in experimental animals hepatoxicity.
The study included rats divided into five groups: negative control, paracetamol (2 g/kg, single oral dose), ALE (1.5 g/kg, orally for 14 d), ALE + paracetamol, and NAC (100 mg/kg) + paracetamol.
The paracetamol treatment group showed marked liver damage observed by significantly increased activities of serum aminotransferases, particularly in the significant increase in hepatic MDA and NO levels, compared with the negative control group.
Paracetamol injection also decreased significantly the levels of antioxidant enzymes produced by the host such as GSH content, GR, GST, and SOD activities.
Furthermore, Paracetamol also induced liver cell apoptosis through its toxicity.
Pretreatment of ALE reversed all the parameters changed above including replenished hepatic GSH, reversed oxidative stress parameters, DNA damage, and necrosis.
Dr. El Morsy EM and colleague wrote in the final report, "ALE may protect from paracetamol-induced liver toxicity via its antioxidant and anti-apoptotic properties".
Taken altogether, artichoke may be considered a functional remedy for the protection of liver against toxicity, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Genotoxic and chemopreventive assessment of Cynara scolymus L. aqueous extract in a human-derived liver cell line by da Silva RP1, Jacociunas LV2, de Carli RF1, de Abreu BRR1, Lehmann M1, da Silva J3, Ferraz ABF4, Dihl RR. (PubMed)
(2) Protective effect of artichoke leaf extract against paracetamol-induced hepatotoxicity in rats by El Morsy EM1, Kamel R. (PubMed)
(3) Immune Deficiency-Related Liver Disease by Hadzic N. (Karger)
Liver protective activity is an action that protects the liver functioning by blocking any substance or pathogens that can cause liver injury or damage.
The exact causes of liver disease are not identified. Researchers do not know why a person is prone to the disease onset while other person does not, even they share a similar health condition and family history
According to the medical literature, there is a perception that liver disease mostly caused by excessive alcohol drinking and viral infection. However, as the time progression, many studies also found that obesity, type 2 diabetes mellitus, dyslipidemia, and metabolic syndrome also play a critical role in developing liver disease.
Some researchers suggested that people with the weakened immune system or immune deficiency are also at an increased risk of liver disease.
Dr. Hadzic N. in the investigation of immune deficiency related liver disease wrote, "It is estimated that around one-quarter of patients with a primary immune deficiency will have some degree of liver involvement".
And, "The most common primary immune deficiencies associated with the liver disease are combined immune deficiency (CID), hyper-IgM syndrome, common variable immunodeficiency, while the commonest liver disease being sclerosing cholangitis"
Most common symptoms of liver disease are jaundice, itchy skin Skin, dark urine color, and pale stool color.
Some patient may also experience symptoms of abdominal pain and swelling, swelling in the legs and ankles and persistent fatigue.
Therefore, if you have some of the aforementioned symptoms, please check with your doctor to rule the possibility.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Searching the list of natural compounds with liver protective activity, researchers examined the effects of artichoke in liver dysfunctions.
The study included the preparation of 4 extract concentrations (0.62, 1.25, 2.5 and 5.0 mg/mL) evaluated on human hepatocyte cultures, HepG2 cells, using the comet assay.
Injection of extract concentrations of 0.62, 1.25 and 2.5 mg/mL, exhibited a significant cytotoxic effect in pretreatment, compared to hydrogen peroxide alone.
However, in simultaneous and post-treatment protocols, only the lowest concentration of artichoke inhibited the frequency of DNA damage caused by hydrogen peroxide.
At highest concentration at 2.5 mg/mL, artichoke extract increased hydrogen peroxide genotoxicity against HepG2 cells.
These results suggested that artichoke leaves aqueous extract induced genotoxic effects in a concentration higher than .62 mg/mL in the tested cell line.
In other words, artichoke extract protects the liver against overexpression of free radicals in the initiation of liver cell damage in a dose-dependent manner.
Dr. da Silva RP, the lead scientist said, "artichoke is genotoxic, in vitro, to HepG2 cells, but can also modulate hydrogen peroxide DNA damage".
In order to reveal more information about artichoke liver protective effects, researchers examined the herbal effects in experimental animals hepatoxicity.
The study included rats divided into five groups: negative control, paracetamol (2 g/kg, single oral dose), ALE (1.5 g/kg, orally for 14 d), ALE + paracetamol, and NAC (100 mg/kg) + paracetamol.
The paracetamol treatment group showed marked liver damage observed by significantly increased activities of serum aminotransferases, particularly in the significant increase in hepatic MDA and NO levels, compared with the negative control group.
Paracetamol injection also decreased significantly the levels of antioxidant enzymes produced by the host such as GSH content, GR, GST, and SOD activities.
Furthermore, Paracetamol also induced liver cell apoptosis through its toxicity.
Pretreatment of ALE reversed all the parameters changed above including replenished hepatic GSH, reversed oxidative stress parameters, DNA damage, and necrosis.
Dr. El Morsy EM and colleague wrote in the final report, "ALE may protect from paracetamol-induced liver toxicity via its antioxidant and anti-apoptotic properties".
Taken altogether, artichoke may be considered a functional remedy for the protection of liver against toxicity, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Genotoxic and chemopreventive assessment of Cynara scolymus L. aqueous extract in a human-derived liver cell line by da Silva RP1, Jacociunas LV2, de Carli RF1, de Abreu BRR1, Lehmann M1, da Silva J3, Ferraz ABF4, Dihl RR. (PubMed)
(2) Protective effect of artichoke leaf extract against paracetamol-induced hepatotoxicity in rats by El Morsy EM1, Kamel R. (PubMed)
(3) Immune Deficiency-Related Liver Disease by Hadzic N. (Karger)
Herbal Catnip In Blocking Entry Phase of Prostate Cancer Onset
Catnip may have a potential and substantial effect in reduced risk of pre-malignant cells slowly change from the properties of normal cells to cancer-like properties in initiated prostate cancer, some scientists suggested.
Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia, used in herbal medicine as insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, colds and flu, skin irritations stimulate sweating, promote menstruation, etc..
Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc..
Prostate cancer is a medical condition characterized by irregular cell growth in the tissues of the prostate. At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistics, based on 2012-2014 data, approximately 11.6 percent of men will be diagnosed with prostate cancer at some points during their lifetime.
On PC3 and DU145 prostate cell lines, in comparison of the effective of methanol extracts, n-hexan, methylene chloride (CH2Cl2), ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O fractions and the essential oil isolated from the aerial parts of the catnip to examine the cytotoxic and apoptogenic activity found that application of ethyl acetate extract in compared to other extracts, displays a strong inhibited property in decreased prostate cancer cell viability in PC3 cell line, through cell cycle arrest in the sub-G1 area, where the cancer cell has lost some DNA structure, in a concentration-dependent manner.
Furthermore, through observation of IC 50 values, ethyl acetate (EtOAc) expressed a greater significant activity in estrogen receptor-positive PC3 cells which are more sensitive to the cytotoxic effects in comparison with low hormone-receptor presenting DU-145 cells.
Interestingly, ethyl acetate (EtOAc) in inhibited PC3 cancer cell line with the lesser value of IC50 and greater effect than other tested compounds was attributed to the activity of PC3 cells can change its negative androgen receptors profile to positive (PC3AR+)
The study also indicated that more cytotoxic activity of N. cataria found on PC3 cells in comparison with DU145 AR¯ cells might also due to different responses of cells to sex hormones.
Additionally, according to the Western blotting analysis administration of ethyl acetate extract after 48 hours securely induced cancer apoptosis through activated caspase 3 cleavage which has been found to be an important marker and in the association with the cell’s entry point into the apoptotic signaling pathway and Poly(ADP-ribose) polymerase (PARP) which also plays an essential role in execution of the apoptotic event and an early indicator of apoptosis.
Moreover, researchers also found that the Catnip extract also increased level of Bax Protein after 48 hours of exposure in initiated cancer cell apoptosis with release of cytochrome c, an early phase of cell degradation and death.
After taking into account other confounders, Dr. Emami SA, the lead author said, " the semi-polar EtOAc extract of N. cataria induces apoptosis in pc3 cells to compare to DU-145 cells and further analytical assays are suggested to identify the active phytochemicals possess cytotoxic activity".
Taking all together, eggplant with plenty of phytochemicals may be considered as a functional food in reduced risk of Prostate cancer by blocking the entry phase of the onset of prostate cancer.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Growth Inhibition and Apoptosis Induction of Essential Oils and Extracts of Nepeta cataria L. on Human Prostatic and Breast Cancer Cell Lines by Emami SA1, Asili J, Hossein Nia S, Yazdian-Robati R, Sahranavard M, Tayarani-Najaran Z. DOI:http://dx.doi.org/10.7314/APJCP.2016.17.S3.125
Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia, used in herbal medicine as insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, colds and flu, skin irritations stimulate sweating, promote menstruation, etc..
Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc..
Prostate cancer is a medical condition characterized by irregular cell growth in the tissues of the prostate. At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistics, based on 2012-2014 data, approximately 11.6 percent of men will be diagnosed with prostate cancer at some points during their lifetime.
On PC3 and DU145 prostate cell lines, in comparison of the effective of methanol extracts, n-hexan, methylene chloride (CH2Cl2), ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O fractions and the essential oil isolated from the aerial parts of the catnip to examine the cytotoxic and apoptogenic activity found that application of ethyl acetate extract in compared to other extracts, displays a strong inhibited property in decreased prostate cancer cell viability in PC3 cell line, through cell cycle arrest in the sub-G1 area, where the cancer cell has lost some DNA structure, in a concentration-dependent manner.
Furthermore, through observation of IC 50 values, ethyl acetate (EtOAc) expressed a greater significant activity in estrogen receptor-positive PC3 cells which are more sensitive to the cytotoxic effects in comparison with low hormone-receptor presenting DU-145 cells.
Interestingly, ethyl acetate (EtOAc) in inhibited PC3 cancer cell line with the lesser value of IC50 and greater effect than other tested compounds was attributed to the activity of PC3 cells can change its negative androgen receptors profile to positive (PC3AR+)
The study also indicated that more cytotoxic activity of N. cataria found on PC3 cells in comparison with DU145 AR¯ cells might also due to different responses of cells to sex hormones.
Additionally, according to the Western blotting analysis administration of ethyl acetate extract after 48 hours securely induced cancer apoptosis through activated caspase 3 cleavage which has been found to be an important marker and in the association with the cell’s entry point into the apoptotic signaling pathway and Poly(ADP-ribose) polymerase (PARP) which also plays an essential role in execution of the apoptotic event and an early indicator of apoptosis.
Moreover, researchers also found that the Catnip extract also increased level of Bax Protein after 48 hours of exposure in initiated cancer cell apoptosis with release of cytochrome c, an early phase of cell degradation and death.
After taking into account other confounders, Dr. Emami SA, the lead author said, " the semi-polar EtOAc extract of N. cataria induces apoptosis in pc3 cells to compare to DU-145 cells and further analytical assays are suggested to identify the active phytochemicals possess cytotoxic activity".
Taking all together, eggplant with plenty of phytochemicals may be considered as a functional food in reduced risk of Prostate cancer by blocking the entry phase of the onset of prostate cancer.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Growth Inhibition and Apoptosis Induction of Essential Oils and Extracts of Nepeta cataria L. on Human Prostatic and Breast Cancer Cell Lines by Emami SA1, Asili J, Hossein Nia S, Yazdian-Robati R, Sahranavard M, Tayarani-Najaran Z. DOI:http://dx.doi.org/10.7314/APJCP.2016.17.S3.125
Wednesday, January 1, 2020
Bromelain Blocks the Onset and progression of Invasive Glioma in Vitro
A glioma is a type of brain and spinal cord tumor characterized by the alternation of DNA of the glial cells.
Believe it or not, gliomas have been found accounting for 30 percent of all brain tumors and central nervous system tumors, and 80 percent of all malignant brain tumors.
Glioma can be classified into 3 types, including
* Astrocytomas are found in glial cells, star-shaped brain cells in the cerebrum called astrocytes. Most astrocytomas are localized.
* Ependymomas are cancers that grow in your brain or any part of the spine, including your neck and upper and lower back starting from the ependymal cells in the middle of your spinal cord and fluid-filled spaces in your brain.
* Oligodendrogliomas are cancers that begin on the oligodendrocytes of the brain or from a glial precursor cell.
The exact cause is unknown. Epidemiologically, age, exposure to radiation and family history are common risk factors that cause the onset of the disease,
Out of many prevalent factors, exposure to ionizing radiation has been found in many patients with glioma.
Dr. Maricruz Rivera, the lead scientist wrote, "Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with a median survival of 12–15 months with treatment consisting of surgical resection followed by ionizing radiation (IR) and chemotherapy".
And, "While IR provides the benefit of improved survival, it paradoxically promotes a selection of more malignant cellular phenotypes of GBM".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential compound for the treatment of invasive glioma cells, researchers investigated bromelain, an aqueous extract from pineapple stem against anti-invasive gliomas.
According to the tested assays, bromelain significantly and reversibly reduced glioma cell adhesion, migration, and invasion without affecting cell viability.
In other words, bromelain inhibited cancer cell proliferation and spreading without inducing cell apoptosis.
Levels of alpha 3 beta 1 integrin-associated with gliomas cells spreading and CD44 protein associated with cancer cell progression were also inhibited by the administration of bromelain without affecting the gene expression.
In other words, the metabolic pathways for de novo nucleotide synthesis in cancer growth were greatly attenuated by bromelain.
Moreover, according to the transactivating signaling assay, bromelain inhibited the invasive glioma cell was also attributed to the suppression of CRE-mediated signaling processes in stimulating the tumor expansion.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of invasive glioma cells. , pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain reversibly inhibits invasive properties of glioma cells by Tysnes BB1, Maurer HR, Porwol T, Probst B, Bjerkvig R, Hoover F. (PubMed)
(2) Ionizing Radiation in Glioblastoma Initiating Cells by Maricruz Rivera,1,2 Kumar Sukhdeo,1,3 and Jennifer Yu. (PMC)
Believe it or not, gliomas have been found accounting for 30 percent of all brain tumors and central nervous system tumors, and 80 percent of all malignant brain tumors.
Glioma can be classified into 3 types, including
* Astrocytomas are found in glial cells, star-shaped brain cells in the cerebrum called astrocytes. Most astrocytomas are localized.
* Ependymomas are cancers that grow in your brain or any part of the spine, including your neck and upper and lower back starting from the ependymal cells in the middle of your spinal cord and fluid-filled spaces in your brain.
* Oligodendrogliomas are cancers that begin on the oligodendrocytes of the brain or from a glial precursor cell.
The exact cause is unknown. Epidemiologically, age, exposure to radiation and family history are common risk factors that cause the onset of the disease,
Out of many prevalent factors, exposure to ionizing radiation has been found in many patients with glioma.
Dr. Maricruz Rivera, the lead scientist wrote, "Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with a median survival of 12–15 months with treatment consisting of surgical resection followed by ionizing radiation (IR) and chemotherapy".
And, "While IR provides the benefit of improved survival, it paradoxically promotes a selection of more malignant cellular phenotypes of GBM".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential compound for the treatment of invasive glioma cells, researchers investigated bromelain, an aqueous extract from pineapple stem against anti-invasive gliomas.
According to the tested assays, bromelain significantly and reversibly reduced glioma cell adhesion, migration, and invasion without affecting cell viability.
In other words, bromelain inhibited cancer cell proliferation and spreading without inducing cell apoptosis.
Levels of alpha 3 beta 1 integrin-associated with gliomas cells spreading and CD44 protein associated with cancer cell progression were also inhibited by the administration of bromelain without affecting the gene expression.
In other words, the metabolic pathways for de novo nucleotide synthesis in cancer growth were greatly attenuated by bromelain.
Moreover, according to the transactivating signaling assay, bromelain inhibited the invasive glioma cell was also attributed to the suppression of CRE-mediated signaling processes in stimulating the tumor expansion.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of invasive glioma cells. , pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain reversibly inhibits invasive properties of glioma cells by Tysnes BB1, Maurer HR, Porwol T, Probst B, Bjerkvig R, Hoover F. (PubMed)
(2) Ionizing Radiation in Glioblastoma Initiating Cells by Maricruz Rivera,1,2 Kumar Sukhdeo,1,3 and Jennifer Yu. (PMC)
Herbal Calendula, the Best in Speeding Up Wound Healing with No Side Effects
Herbal may have a strong effect on speeding up wound healing, according to studies by a number of institutes.
Wound healing is a natural process of our body by restoring the function of the damaged or injured tissue through several stages.
Most importantly, the early stage of wound healing is also known as an acute phase of infection, which starts as soon as the immune system sensing the tissue damage by stimulating the blood vessels to provide the damaged tissue with blood palette to cover the wound temporarily and activated the proteins associated with the production of inflammatory cytokines to the site of infection with an aim to kill off all micro invaders.
In most cases, the immune first line of defense can destroy the pathogens and speed up the recovery of the damage through inducing fiber tissue reconstruction, new blood vessels.
However, overproduction of a proinflammatory cytokine in this phase may cause damage and death of nearby cells, leading to the formation of scars.
If the immune system can not kill off all the invaded pathogens within a set of times, normally in 3-8 weeks, it will adapt to the new change, leading to low-grade inflammation, a major cause of several chronic ailments, including diabetes, heart diseases.
If the process of wound healing is disrupted, it may also lead to improper wound healing with complications, including inadequate scar formation, excessive scar formation, and a contracture formation, an exaggeration of normal wound edge contraction forming deformities.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe. It has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and for the treatment of abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Besides major chemical constituents of triterpenoids, flavonoids, coumarins, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Researchers on finding a natural ingredient for speeding up wound healing examined the effect of Calendula officinalis, an annual herb from the Mediterranean origin which is popularly used in wound healing and as an anti-inflammatory agent.
Injection of C. officinalis demonstrated significantly anti-inflammatory and antibacterial activities in protecting the wound against infection.
Furthermore, C. officinalis also speed up the wound healing process by enhancing the angiogenic and fibroblastic properties.
The findings strongly suggested that herbal Calendula can act in a positive way on the inflammatory and proliferative phases of the healing process.
Moreover, in the evaluation of the effects of oral and topical application of Calendula officinalis flower extract on excision wounds made in rats, compared to the control of 51.1%, oral and topical application of Calendula showed a wound closure was 90.0%.
The extract treatment at a dose of 20 or 100 mg/kg b.wt reduced the period needed for re-epithelization to 14 and 13 days, respectively compared to 17.7 days in the control.
Additionally, the extract-treated group also exhibited a significant increase in the concentration of collagen. compared to the untreated animals.
Interestingly, in a total of 36 rats and 90 embryonated eggs used to evaluate healing and angiogenic activities of extracts and fractions of Calendula, through the induction of skin wounds and the chorioallantoic membrane, respectively, researchers found that
* Injection of calendula extract exerted an angiogenic activity in speeding up wound healing in both experimental models.
* The efficacy was not attributed to the signal protein produced by cells that stimulate the formation of blood vessels, but other unknown pro-angiogenic factors.
Taken altogether, herbal Calendula may be considered a functional remedy for speeding up wound healing with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil by Parente LM1, Lino Júnior Rde S, Tresvenzol LM, Vinaud MC, de Paula JR, Paulo NM.(PubMed)
(2) Angiogenic activity of Calendula officinalis flowers L. in rats by Parente LM1, Andrade MA, Brito LA, Moura VM, Miguel MP, Lino-Júnior Rde S, Tresvenzol LF, Paula JR, Paulo NM.(PubMed)
(3) Wound healing activity of flower extract of Calendula officinalis by Preethi KC1, Kuttan R.(PubMed)
Wound healing is a natural process of our body by restoring the function of the damaged or injured tissue through several stages.
Most importantly, the early stage of wound healing is also known as an acute phase of infection, which starts as soon as the immune system sensing the tissue damage by stimulating the blood vessels to provide the damaged tissue with blood palette to cover the wound temporarily and activated the proteins associated with the production of inflammatory cytokines to the site of infection with an aim to kill off all micro invaders.
In most cases, the immune first line of defense can destroy the pathogens and speed up the recovery of the damage through inducing fiber tissue reconstruction, new blood vessels.
However, overproduction of a proinflammatory cytokine in this phase may cause damage and death of nearby cells, leading to the formation of scars.
If the immune system can not kill off all the invaded pathogens within a set of times, normally in 3-8 weeks, it will adapt to the new change, leading to low-grade inflammation, a major cause of several chronic ailments, including diabetes, heart diseases.
If the process of wound healing is disrupted, it may also lead to improper wound healing with complications, including inadequate scar formation, excessive scar formation, and a contracture formation, an exaggeration of normal wound edge contraction forming deformities.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe. It has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and for the treatment of abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Besides major chemical constituents of triterpenoids, flavonoids, coumarins, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Researchers on finding a natural ingredient for speeding up wound healing examined the effect of Calendula officinalis, an annual herb from the Mediterranean origin which is popularly used in wound healing and as an anti-inflammatory agent.
Injection of C. officinalis demonstrated significantly anti-inflammatory and antibacterial activities in protecting the wound against infection.
Furthermore, C. officinalis also speed up the wound healing process by enhancing the angiogenic and fibroblastic properties.
The findings strongly suggested that herbal Calendula can act in a positive way on the inflammatory and proliferative phases of the healing process.
Moreover, in the evaluation of the effects of oral and topical application of Calendula officinalis flower extract on excision wounds made in rats, compared to the control of 51.1%, oral and topical application of Calendula showed a wound closure was 90.0%.
The extract treatment at a dose of 20 or 100 mg/kg b.wt reduced the period needed for re-epithelization to 14 and 13 days, respectively compared to 17.7 days in the control.
Additionally, the extract-treated group also exhibited a significant increase in the concentration of collagen. compared to the untreated animals.
Interestingly, in a total of 36 rats and 90 embryonated eggs used to evaluate healing and angiogenic activities of extracts and fractions of Calendula, through the induction of skin wounds and the chorioallantoic membrane, respectively, researchers found that
* Injection of calendula extract exerted an angiogenic activity in speeding up wound healing in both experimental models.
* The efficacy was not attributed to the signal protein produced by cells that stimulate the formation of blood vessels, but other unknown pro-angiogenic factors.
Taken altogether, herbal Calendula may be considered a functional remedy for speeding up wound healing with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil by Parente LM1, Lino Júnior Rde S, Tresvenzol LM, Vinaud MC, de Paula JR, Paulo NM.(PubMed)
(2) Angiogenic activity of Calendula officinalis flowers L. in rats by Parente LM1, Andrade MA, Brito LA, Moura VM, Miguel MP, Lino-Júnior Rde S, Tresvenzol LF, Paula JR, Paulo NM.(PubMed)
(3) Wound healing activity of flower extract of Calendula officinalis by Preethi KC1, Kuttan R.(PubMed)
Cat's claw, The best Whole Herb Medicine for Treatment of Parkinson disease
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Parkinson disease is a type of dementia caused by dysfunction of nerve cells that produce dopamine in the brain, affecting muscle rigidity, tremors, changes in speech and gait.
Uncaria tomentosa may be one of the medical plants used for reduced symptoms and treatment of Parkinson's disease.
According to the recent study, AC11 (a standardized aqueous extract of Uncaria tomentosa) exhibited scavenged several types of free radicals, decreased the level of lipid peroxidation and reduced aggregation of α-synuclein by 40%.
Dr. Cosentino C. the lead researcher at the Instituto de Ciencias Neurologicas, said, "Uncaria tomentosa (UT),,... reversed worsening of motor signs in a patient with Parkinson disease after oral intake"
Further study of Cat's Claw (Uncaria tomentosa) also found that the medical plant enhanced DNA repair and immunity in model systems with the capability of generated neuroprotective effects in neurons.
Although the therapeutic intervention of Cat's claw may exhibit the properties against Parkinson's disease, the use of the medicinal plant should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model byShi Z1, Lu Z, Zhao Y, Wang Y, Zhao-Wilson X, Guan P, Duan X, Chang YZ, Zhao B.(PubMed)
(2) Reversible worsening of Parkinson disease motor symptoms after oral intake of Uncaria tomentosa (cat's claw) by Cosentino C1, Torres L.(PubMed)
(3) Quinic acid could be a potential rejuvenating natural compound by improving survival of Caenorhabditis elegans under deleterious conditions by Zhang L1, Zhang J, Zhao B, Zhao-Wilson X.(PubMed)
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Parkinson disease is a type of dementia caused by dysfunction of nerve cells that produce dopamine in the brain, affecting muscle rigidity, tremors, changes in speech and gait.
Uncaria tomentosa may be one of the medical plants used for reduced symptoms and treatment of Parkinson's disease.
According to the recent study, AC11 (a standardized aqueous extract of Uncaria tomentosa) exhibited scavenged several types of free radicals, decreased the level of lipid peroxidation and reduced aggregation of α-synuclein by 40%.
Dr. Cosentino C. the lead researcher at the Instituto de Ciencias Neurologicas, said, "Uncaria tomentosa (UT),,... reversed worsening of motor signs in a patient with Parkinson disease after oral intake"
Further study of Cat's Claw (Uncaria tomentosa) also found that the medical plant enhanced DNA repair and immunity in model systems with the capability of generated neuroprotective effects in neurons.
Although the therapeutic intervention of Cat's claw may exhibit the properties against Parkinson's disease, the use of the medicinal plant should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model byShi Z1, Lu Z, Zhao Y, Wang Y, Zhao-Wilson X, Guan P, Duan X, Chang YZ, Zhao B.(PubMed)
(2) Reversible worsening of Parkinson disease motor symptoms after oral intake of Uncaria tomentosa (cat's claw) by Cosentino C1, Torres L.(PubMed)
(3) Quinic acid could be a potential rejuvenating natural compound by improving survival of Caenorhabditis elegans under deleterious conditions by Zhang L1, Zhang J, Zhao B, Zhao-Wilson X.(PubMed)
Tuesday, December 31, 2019
Herbal Ashwagandha Inhibits the Risk of Chronic Generalized Periodontitis
Gingivitis is a common and mild form of periodontal disease caused by inflammation of the gingiva, leading to symptoms of irritation, redness, and swelling of the gum that lines the base of the teeth.
Gingivitis dental plaques formed around the base of the teeth are sticky biofilm of bacteria associated with the interaction of the food intake and bacteria in the mouth. Over time, if untreated, the condition can lead to periodontitis and advanced periodontitis.
At this early stage, the bone and connective tissue that hold the teeth in place are not yet affected. The problems can be reversed by more frequent and proper brushing and flossing.
The most common cause of gingivitis is poor hygiene. Epidemiologically, risk factors induce the onset of gingivitis are smoking or chewing tobacco. diabetes and long-term use of certain medication including oral contraceptives, steroids, anticonvulsants, calcium channel blockers.
Some people under the treatment of chemotherapy may also experience symptoms of gingivitis.
Periodontitis is a severe stage of gingivitis that damages the soft tissue and destroys the bone that supports your teeth, leading to teeth loosen or tooth loss.
Periodontitis can be classified into
* Chronic periodontitis is caused by plaque buildup and involves the slow deterioration of the gums and bone and loss of teeth if not treated. The condition is a common condition that affects mostly adults.
* Aggressive periodontitis found mostly in childhood or early adulthood. The condition is rare that causes rapid progression of bone and tooth loss if untreated.
* Necrotizing periodontal disease is a severe infection that causes the death of gum tissue, tooth ligaments and supporting bone.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of oral health, researchers examined the effects of WA on periodontitis.
In vitro, Herbal ashwagandha possessed a marked anti-inflammatory effect against the denaturation of proteins associated with the loss of the quaternary structure, tertiary structure, and secondary structure, probably through the herbal alkaloid and withanolide contents.
Furthermore, herbal ashwagandha also induced adaptogenic, immunomodulating, antibacterial, anti-inflammatory against on the onset of periodontitis.
The enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase produced by the host are increased by the administration of WA against bacterial-induced inflammatory periodontitis.
Moreover, Ashwagandha supplementation also showed to process activity to act as an adjunct to scaling and root planing(SRP) in chronic periodontitis(CP) patients by inhibiting oxidative stress (OS) and increased levels of acute-phase proteins associated with gingival inflammation and periodontitis.
Based on the findings, researchers said, "Changes in peripheral blood cellular and molecular components can be seen in patients with periodontitis, as periodontitis includes inflammatory changes of the periodontal tissues".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of periodontitis, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis by NIH
(2) Periodontitis by Mayo Clinic
Gingivitis dental plaques formed around the base of the teeth are sticky biofilm of bacteria associated with the interaction of the food intake and bacteria in the mouth. Over time, if untreated, the condition can lead to periodontitis and advanced periodontitis.
At this early stage, the bone and connective tissue that hold the teeth in place are not yet affected. The problems can be reversed by more frequent and proper brushing and flossing.
The most common cause of gingivitis is poor hygiene. Epidemiologically, risk factors induce the onset of gingivitis are smoking or chewing tobacco. diabetes and long-term use of certain medication including oral contraceptives, steroids, anticonvulsants, calcium channel blockers.
Some people under the treatment of chemotherapy may also experience symptoms of gingivitis.
Periodontitis is a severe stage of gingivitis that damages the soft tissue and destroys the bone that supports your teeth, leading to teeth loosen or tooth loss.
Periodontitis can be classified into
* Chronic periodontitis is caused by plaque buildup and involves the slow deterioration of the gums and bone and loss of teeth if not treated. The condition is a common condition that affects mostly adults.
* Aggressive periodontitis found mostly in childhood or early adulthood. The condition is rare that causes rapid progression of bone and tooth loss if untreated.
* Necrotizing periodontal disease is a severe infection that causes the death of gum tissue, tooth ligaments and supporting bone.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of oral health, researchers examined the effects of WA on periodontitis.
In vitro, Herbal ashwagandha possessed a marked anti-inflammatory effect against the denaturation of proteins associated with the loss of the quaternary structure, tertiary structure, and secondary structure, probably through the herbal alkaloid and withanolide contents.
Furthermore, herbal ashwagandha also induced adaptogenic, immunomodulating, antibacterial, anti-inflammatory against on the onset of periodontitis.
The enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase produced by the host are increased by the administration of WA against bacterial-induced inflammatory periodontitis.
Moreover, Ashwagandha supplementation also showed to process activity to act as an adjunct to scaling and root planing(SRP) in chronic periodontitis(CP) patients by inhibiting oxidative stress (OS) and increased levels of acute-phase proteins associated with gingival inflammation and periodontitis.
Based on the findings, researchers said, "Changes in peripheral blood cellular and molecular components can be seen in patients with periodontitis, as periodontitis includes inflammatory changes of the periodontal tissues".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of periodontitis, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis by NIH
(2) Periodontitis by Mayo Clinic
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