Chronic stress is the response to emotional pressure in demanding situations over a period of time, leading to the release of hormone cortisol and adrenaline.
The most common factors associated with stress incidence include psychological pressures, such as work deadlines, and exams, high-pressure jobs, and financial difficulties.
Overtime unresolved chronic stress can cause a wide range of symptoms and increase the risk of anxiety.
Anxiety disorder is a class of medical conditions associated with chronic worries and fear, leading to symptoms of the fast heart rate and shakiness.
Most people with anxiety may experience the feeling of nervousness in responding to events such as a problem at work, before taking a test, or before making an important decision.
According to the statistics, anxiety disorders are the most common mental illness in Canada and approximately 1 in every 8 Canadians is affected by the illness. In other words, over 250,000 people in Canada suffer from anxiety.
Most common prevalent factors that induce the risk of the condition are, family history, gender (women are more likely diagnosed with the condition compared to men), chronic stress, people with traumatic life experiences and the use of substances are some prevalent risk factors of anxiety.
However, some researchers suggested a moderate physical activity, mind-body practices of breathing exercises, yoga, and meditation have been found to reduce stress, a strong positive impact against anxiety.
The Anxiety and Depression Association of America wrote, "Whether, in good times or bad, most people say that stress interferes at least moderately with their lives. Chronic stress can affect your health, causing symptoms from headaches, high blood pressure, and chest pain to heart palpitations, skin rashes, and loss of sleep".
"Physical activity is a proven way to reduce stress. Regular participation in aerobic exercise has been shown to decrease overall levels of tension, elevate and stabilize mood, and improve sleep and self-esteem. Other effective methods include mind-body practices of breathing exercises, yoga, and meditation".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of symptoms associated with chronic stress, researchers examined the efficacy of a high-concentration full-spectrum extract of Ashwagandha roots in reducing stress and anxiety in adults who were under stress.
A total of 64 subjects with a history of chronic stress included were randomized to either drug treatment group and were asked to take one capsule containing 300 mg of high-concentration full-spectrum extract from the root of the Ashwagandha plant or the placebo control group. twice a day for a period of 60 days.
Based on the results of the tested analysis, the treatment group received a high-concentration full-spectrum Ashwagandha root extract showed a significant reduction in scores on all the stress-assessment scales on Day 60 compared to placebo.
The serum cortisol levels were substantially reduced in the Ashwagandha group, compared to the placebo group.
According to the patient's reports, there are no serious adverse events reported during the experimental period.
In other words, the short-term application of the Ashwagandha plant at a high concentration not only reduced the levels of c stress but also stress-induced hormone expression of anxiety.
Based on the findings, researchers said, "a high-concentration full-spectrum Ashwagandha root extract safely and effectively improves an individual's resistance towards stress and thereby improves self-assessed quality of life".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention of anxiety induced by chronic stress, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera) by Pratte MA1, Nanavati KB, Young V, Morley CP. (PubMed)
(2) A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults by Chandrasekhar K1, Kapoor J, Anishetty S. (PubMed)
(3) Stress by the Anxiety and Depression Association of America
Monday, January 6, 2020
Bromelain Exerts Anti Inflammatory Effects on Airway Inflammation In Vivo
Inflammation is a natural defense of the immune system that tries to protect the body against the insult from the foreign invasion.
Acute inflammation occurs quickly or within the hours and lasts a few days or weeks and the damage tissues are healed themselves after all pathogens are killed off.
However, if the immune system can not completely eradicate all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.
Airway inflammation is a lung inflammatory caused by both allergens and immune mistakenly attacks the respiratory tissues.
Chronic airway disease predominantly asthma and chronic obstructive pulmonary disease (COPD) have been increased at an alarming rate in the US over the past 20 years.
According to the statistics provided by the WHO, globally, approximately 65 million people suffer from chronic obstructive pulmonary disease (COPD), causing the death of 3 million each year. and 334 million people suffer from asthma, affecting 14% of all children globally.
In the US, the prevalence of chronic airway disease was found to cause a major financial burden to society, with both direct and indirect costs.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to discover a natural compound for the treatment of airway inflammation, researchers examined the benefits of alternative asthma treatments, including the ability of bromelain to inhibit inflammation, accompanied by a lifestyle change.
Preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD) selected to the investigation were randomly assigned to receive phosphate-buffered saline (PBS) only or bromelain in PBS.as an intervention group.
According to the results of the sensitized female C57BL/6J mice with intraperitoneal OVA/alum and then challenged them with OVA aerosolization for 10 consecutive days followed by administering daily doses of PBS to the control group (n = 10) and bromelain (6mg/kg) in PBS to the bromelain (intervention) group (n = 10) on day 4, intervention group demonstrated a significant increase of anti-inflammatory activity observed by the reduced BAL total leukocytes (P < .05), eosinophils (P < .05), and cellular infiltrates via lung pathology (P < .005), compared to the control group.
Interesting, bromelain significantly reduced BAL CD4+ and CD8+ T cells ratio without affecting cell numbers in the spleen or hilar lymph node, an indication of reduced hypersensitivity of the immunity.
In other words, bromelain protects the airway inflammation in the asthmatic animals by inhibiting the production of pro-inflammatory cytokines through its anti-inflammation property.
Based on the findings, researchers wrote, "bromelain has a therapeutic effect in established AAD, which may translate into an effective adjunctive therapy in patients with similar conditions, such as allergic asthma, who have chosen to initiate treatment after the onset of symptoms".
Also, according to the results of another study included ovalbumin (OVA)-induced murine model of allergic airway disease (AAD) assigned to either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days., bromelain treatment of AAD mice exerted a similar effect compared to the aforementioned experiment.
Bromelain reduced total BAL leukocytes, eosinophils, CD4+ and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13, through its anti-inflammatory activity.
Dr. Secor ER Jr, the lead scientist wrote at the final report, "The reduction in AAD outcomes suggests that bromelain may have similar effects in the treatment of human asthma and hypersensitivity disorders".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of allergic airway inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease by Secor ER Jr1, Carson WF 4th, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS. (PubMed)
Acute inflammation occurs quickly or within the hours and lasts a few days or weeks and the damage tissues are healed themselves after all pathogens are killed off.
However, if the immune system can not completely eradicate all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.
Airway inflammation is a lung inflammatory caused by both allergens and immune mistakenly attacks the respiratory tissues.
Chronic airway disease predominantly asthma and chronic obstructive pulmonary disease (COPD) have been increased at an alarming rate in the US over the past 20 years.
According to the statistics provided by the WHO, globally, approximately 65 million people suffer from chronic obstructive pulmonary disease (COPD), causing the death of 3 million each year. and 334 million people suffer from asthma, affecting 14% of all children globally.
In the US, the prevalence of chronic airway disease was found to cause a major financial burden to society, with both direct and indirect costs.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to discover a natural compound for the treatment of airway inflammation, researchers examined the benefits of alternative asthma treatments, including the ability of bromelain to inhibit inflammation, accompanied by a lifestyle change.
Preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD) selected to the investigation were randomly assigned to receive phosphate-buffered saline (PBS) only or bromelain in PBS.as an intervention group.
According to the results of the sensitized female C57BL/6J mice with intraperitoneal OVA/alum and then challenged them with OVA aerosolization for 10 consecutive days followed by administering daily doses of PBS to the control group (n = 10) and bromelain (6mg/kg) in PBS to the bromelain (intervention) group (n = 10) on day 4, intervention group demonstrated a significant increase of anti-inflammatory activity observed by the reduced BAL total leukocytes (P < .05), eosinophils (P < .05), and cellular infiltrates via lung pathology (P < .005), compared to the control group.
Interesting, bromelain significantly reduced BAL CD4+ and CD8+ T cells ratio without affecting cell numbers in the spleen or hilar lymph node, an indication of reduced hypersensitivity of the immunity.
In other words, bromelain protects the airway inflammation in the asthmatic animals by inhibiting the production of pro-inflammatory cytokines through its anti-inflammation property.
Based on the findings, researchers wrote, "bromelain has a therapeutic effect in established AAD, which may translate into an effective adjunctive therapy in patients with similar conditions, such as allergic asthma, who have chosen to initiate treatment after the onset of symptoms".
Also, according to the results of another study included ovalbumin (OVA)-induced murine model of allergic airway disease (AAD) assigned to either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days., bromelain treatment of AAD mice exerted a similar effect compared to the aforementioned experiment.
Bromelain reduced total BAL leukocytes, eosinophils, CD4+ and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13, through its anti-inflammatory activity.
Dr. Secor ER Jr, the lead scientist wrote at the final report, "The reduction in AAD outcomes suggests that bromelain may have similar effects in the treatment of human asthma and hypersensitivity disorders".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of allergic airway inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease by Secor ER Jr1, Carson WF 4th, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS. (PubMed)
Cat's claw, The best Whole Herb Medicine for Treatment of Breast Cancer
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk
There are also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.
A recent study of prevention in experimental diabetes suggested that Uncaria tomentosa (Willd.) may be effective in reduced the risk and treatment of breast cancer.
Hydroalcoholic extract of U. tomentosa is found to associate with a reduction of accelerated tumor progression through many biological aspects.
Study of C57BL/6 male mice injected with MLDS (40 mg/kg) and orally treated with UT at 10-400mg/kg during 21 days, showed a higher number of intact islets and a significant inhibition of destructive insulitis, and significant protection against the loss of insulin-secreting presented β-cells.
The plant also expressed a high level of modulation of the immune system. Immunomodulatory properties of the medicinal plants showed to mitigate breast cancer cell growth, through immune cell types participate in the process especially cytotoxic T cells and natural killer cells, and cytokines.
In MT-3 and MCF7 cell lines, U. tomentosa also exhibited antiproliferative, cytotoxic, cytostatic and anti-inflammatory activity as well as mutagenic and antimutagenic properties.
Dr. Baraya YS, the lead author said, "Curcuma longa was reported to hold strong potential in breast cancer treatment in various parts of the world. Interestingly, research findings have shown that these plants possess bioactive immunomodulators as their main constituents producing the anticancer effects".
Furthermore, in vitro, immunomodulatory effects of a Uncaria tomentosa hydroalcoholic extract exhibited an anti-breast cancer effect by increased the production of cytokines related to the anti-tumoral response at concentrations of 500-1000 μg/mL.
In a randomized clinical trial of treatment for breast cancer, Uncaria tomentosa (Ut) not only reduced the adverse effects of chemotherapy but also enhanced immunological parameters, antioxidant enzymes, and attenuated oxidative stress cause of cellular DNA damage.
The herbal plant, Cat's claw has shown its effects in the treatment of breast cancer through many aspects, but the use of the plant must be only given by herbalists, as the quality and quantity may be different due to geography, time of harvest and where the plant was grown.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Uncaria tomentosa extract alters the catabolism of adenine nucleotides and expression of ecto-5'-nucleotidase/CD73 and P2X7 and A1 receptors in the MDA-MB-231 cell line. by Santos KF1, Gutierres JM2, Pillat MM3, Rissi VB4, Santos Araújo MD5, Bertol G6, Gonçalves PB4, Schetinger MR2, Morsch VM7(PubMed)
(2) The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review by Baraya YS1, Wong KK2, Yaacob NS3(PubMed).
(3) [Immunomodulation of Uncaria tomentosa over dendritic cells, il-12 and profile TH1/TH2/TH17 in breast cancer].[Article in Spanish]by Núñez C1, Lozada-Requena I1, Ysmodes T1, Zegarra D1, Saldaña F1, Aguilar J1.(PubMed)
(4) Uncaria tomentosa-Adjuvant Treatment for Breast Cancer: Clinical Trial by Santos Araújo Mdo C1, Farias IL, Gutierres J, Dalmora SL, Flores N, Farias J, de Cruz I, Chiesa J, Morsch VM, Chitolina Schetinger MR.(PubMed)
(5) Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines by García Giménez D1, García Prado E, Sáenz Rodríguez T, Fernández Arche A, De la Puerta R.(PubMed)
(6) The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line by Riva L1, Coradini D, Di Fronzo G, De Feo V, De Tommasi N, De Simone F, Pizza C.(PubMed)
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk
There are also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.
A recent study of prevention in experimental diabetes suggested that Uncaria tomentosa (Willd.) may be effective in reduced the risk and treatment of breast cancer.
Hydroalcoholic extract of U. tomentosa is found to associate with a reduction of accelerated tumor progression through many biological aspects.
Study of C57BL/6 male mice injected with MLDS (40 mg/kg) and orally treated with UT at 10-400mg/kg during 21 days, showed a higher number of intact islets and a significant inhibition of destructive insulitis, and significant protection against the loss of insulin-secreting presented β-cells.
The plant also expressed a high level of modulation of the immune system. Immunomodulatory properties of the medicinal plants showed to mitigate breast cancer cell growth, through immune cell types participate in the process especially cytotoxic T cells and natural killer cells, and cytokines.
In MT-3 and MCF7 cell lines, U. tomentosa also exhibited antiproliferative, cytotoxic, cytostatic and anti-inflammatory activity as well as mutagenic and antimutagenic properties.
Dr. Baraya YS, the lead author said, "Curcuma longa was reported to hold strong potential in breast cancer treatment in various parts of the world. Interestingly, research findings have shown that these plants possess bioactive immunomodulators as their main constituents producing the anticancer effects".
Furthermore, in vitro, immunomodulatory effects of a Uncaria tomentosa hydroalcoholic extract exhibited an anti-breast cancer effect by increased the production of cytokines related to the anti-tumoral response at concentrations of 500-1000 μg/mL.
In a randomized clinical trial of treatment for breast cancer, Uncaria tomentosa (Ut) not only reduced the adverse effects of chemotherapy but also enhanced immunological parameters, antioxidant enzymes, and attenuated oxidative stress cause of cellular DNA damage.
The herbal plant, Cat's claw has shown its effects in the treatment of breast cancer through many aspects, but the use of the plant must be only given by herbalists, as the quality and quantity may be different due to geography, time of harvest and where the plant was grown.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Uncaria tomentosa extract alters the catabolism of adenine nucleotides and expression of ecto-5'-nucleotidase/CD73 and P2X7 and A1 receptors in the MDA-MB-231 cell line. by Santos KF1, Gutierres JM2, Pillat MM3, Rissi VB4, Santos Araújo MD5, Bertol G6, Gonçalves PB4, Schetinger MR2, Morsch VM7(PubMed)
(2) The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review by Baraya YS1, Wong KK2, Yaacob NS3(PubMed).
(3) [Immunomodulation of Uncaria tomentosa over dendritic cells, il-12 and profile TH1/TH2/TH17 in breast cancer].[Article in Spanish]by Núñez C1, Lozada-Requena I1, Ysmodes T1, Zegarra D1, Saldaña F1, Aguilar J1.(PubMed)
(4) Uncaria tomentosa-Adjuvant Treatment for Breast Cancer: Clinical Trial by Santos Araújo Mdo C1, Farias IL, Gutierres J, Dalmora SL, Flores N, Farias J, de Cruz I, Chiesa J, Morsch VM, Chitolina Schetinger MR.(PubMed)
(5) Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines by García Giménez D1, García Prado E, Sáenz Rodríguez T, Fernández Arche A, De la Puerta R.(PubMed)
(6) The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line by Riva L1, Coradini D, Di Fronzo G, De Feo V, De Tommasi N, De Simone F, Pizza C.(PubMed)
Sunday, January 5, 2020
Herbal Burdock, the Best Anti Diabetes and Diabetic Complications Functional Remedy, Scientists Find
Scientists may have found a herbal medicine for the prevention and treatment of diabetes with no side effects, according to studies.
Diabetes is a medical and chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.
The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol.
Some researchers suggested that high blood cholesterol is one major risk factor that not only contributed to the risk of obesity but also facilitates the onset of diabetes.
How to calculate your blood cholesterol, If the ratio your blood cholesterol is higher than 4, you have high blood cholesterol.
The normal ratio of blood cholesterol is 4 (low-density lipoprotein or bad cholesterol)/ 1 ( high-density lipoprotein or good cholesterol). Any number which is higher than 4 is considered high blood cholesterol.
How high blood cholesterol associated with diabetes
* Most patients with diabetes also have a syndrome oh high blood cholesterol.
* According to Dr. Michael Greger M.D's long-term intake of a high-fat diet is associated with diabetes. According to the study of young, healthy people and split them up into two groups, high fat intake within 2 days demonstrated, a significant rise of glucose intolerance. During the course of the study, the high-fat diet group ended up with twice the blood sugar compared to the carbohydrate-rich diet group.
* Also the spike of blood sugar in the high-fat diet group may also increase the onset of insulin resistance due to insulin no longer performs its function in activating the function of the insulin receptors site which now clogged up by cholesterol to stimulating the enzymes associated with glucose transport.
In other words, the pancreas beta cells will continue to produce insulin but can not lower the blood glucose due to the disruption of glucose metabolism, leading to insulin resistance, the major cause of diabetes.
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. The herbal medicine has been using thousands of year in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
It contains carbonated water, sugar,, manloid colorings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.
With an aim to find a natural medicine for the treatment of diabetes and reduced the diabetic retinopathy is one of the most common and severe complications of diabetes mellitus, researchers at the Third Military Medical University examined Arctiin, a bioactive compound isolated from the dry seeds of Arctium lappa L.(Burdock), antidiabetic activity.
Male Sprague-Dawley rats induced diabetes are randomly divided into five groups (n = 20 per group) and treated with intragastric doses of 30, 90, or 270 mg/kg/d wt of arctiin, 100 mg/kg/d wt of calcium dobesilate, or 0.5 % CMC-Na and 20 nondiabetic sham-treated rats were treated with 0.5 % CMC-Na.
In the beginning, there was no significantly different occurrence of diabetic retinopathy among the groups.
However, at the week 16, the glycosylated hemoglobin (HBA1c) level was significantly decreased in all of the arctiin-treated groups when compared with the control group, and the serum glucose level was also decreased in the rats treated with the highest dose of arctiin
The normal levels of HbA1c of 6.5% and HbA1c are used as an objective measure of glycaemic control.
The highest dose of the arctiin group showed a decrease in the serum glucose level which was elevated by the induction of diabetes.
Arctiin treatment group displayed a reduced inflammatory in the expression of retinal edema, detachment of the retina, and levels of pro-inflammatory cytokines observed by the histological and immunochemical examinations.
Furthermore, arctiin also increased the viability of retinal microvascular endothelial cells which reduced in diabetic rats, in vitro.
Dr. Lu LC, the lead scientist wrote, "these findings demonstrate that arctiin decreases the severity of diabetic complications, demonstrating the importance of this compound as an inhibitor of diabetic retinopathy".
Additionally, in the review of anti-diabetes effects of the active compounds present in the different botanical parts of burdock, researchers examined the active ingredients in the roots and seed.
The results of the chemical analysis suggested that the compounds isolated from root showed a strong effect in the inhibition of diabetes through its antioxidant activity.
In the seeds, some active compounds possess anti-inflammatory effects similar to that of arctiin treatment rats group.
These results suggested that herbal burdock exerted a strong anti-diabetes and diabetic complication through its glycaemic control and antioxidant and anti-inflammatory properties.
Taken altogether, herbal Burdock processed high numbers of the bioactive compound may be considered a functional herb for the prevention and combined with the primary medicine for the treatment of diabetes and diabetic complication.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of arctiin on streptozotocin-induced diabetic retinopathy in Sprague-Dawley rats by Lu LC, Zhou W, Li ZH, Yu CP, Li CW, Luo MH, Xie H.(PubMed)
(2) A review of the pharmacological effects of Arctium lappa (burdock) by Chan YS1, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, Leung GP, Yu PH, Chan SW. (PubMed)
(3) Fat is the Cause of Type 2 Diabetes by Written By Michael Greger M.D. FACLM on November 17th, 2016. (Nutrition Facts)
Diabetes is a medical and chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.
The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol.
Some researchers suggested that high blood cholesterol is one major risk factor that not only contributed to the risk of obesity but also facilitates the onset of diabetes.
How to calculate your blood cholesterol, If the ratio your blood cholesterol is higher than 4, you have high blood cholesterol.
The normal ratio of blood cholesterol is 4 (low-density lipoprotein or bad cholesterol)/ 1 ( high-density lipoprotein or good cholesterol). Any number which is higher than 4 is considered high blood cholesterol.
How high blood cholesterol associated with diabetes
* Most patients with diabetes also have a syndrome oh high blood cholesterol.
* According to Dr. Michael Greger M.D's long-term intake of a high-fat diet is associated with diabetes. According to the study of young, healthy people and split them up into two groups, high fat intake within 2 days demonstrated, a significant rise of glucose intolerance. During the course of the study, the high-fat diet group ended up with twice the blood sugar compared to the carbohydrate-rich diet group.
* Also the spike of blood sugar in the high-fat diet group may also increase the onset of insulin resistance due to insulin no longer performs its function in activating the function of the insulin receptors site which now clogged up by cholesterol to stimulating the enzymes associated with glucose transport.
In other words, the pancreas beta cells will continue to produce insulin but can not lower the blood glucose due to the disruption of glucose metabolism, leading to insulin resistance, the major cause of diabetes.
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. The herbal medicine has been using thousands of year in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
It contains carbonated water, sugar,, manloid colorings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.
With an aim to find a natural medicine for the treatment of diabetes and reduced the diabetic retinopathy is one of the most common and severe complications of diabetes mellitus, researchers at the Third Military Medical University examined Arctiin, a bioactive compound isolated from the dry seeds of Arctium lappa L.(Burdock), antidiabetic activity.
Male Sprague-Dawley rats induced diabetes are randomly divided into five groups (n = 20 per group) and treated with intragastric doses of 30, 90, or 270 mg/kg/d wt of arctiin, 100 mg/kg/d wt of calcium dobesilate, or 0.5 % CMC-Na and 20 nondiabetic sham-treated rats were treated with 0.5 % CMC-Na.
In the beginning, there was no significantly different occurrence of diabetic retinopathy among the groups.
However, at the week 16, the glycosylated hemoglobin (HBA1c) level was significantly decreased in all of the arctiin-treated groups when compared with the control group, and the serum glucose level was also decreased in the rats treated with the highest dose of arctiin
The normal levels of HbA1c of 6.5% and HbA1c are used as an objective measure of glycaemic control.
The highest dose of the arctiin group showed a decrease in the serum glucose level which was elevated by the induction of diabetes.
Arctiin treatment group displayed a reduced inflammatory in the expression of retinal edema, detachment of the retina, and levels of pro-inflammatory cytokines observed by the histological and immunochemical examinations.
Furthermore, arctiin also increased the viability of retinal microvascular endothelial cells which reduced in diabetic rats, in vitro.
Dr. Lu LC, the lead scientist wrote, "these findings demonstrate that arctiin decreases the severity of diabetic complications, demonstrating the importance of this compound as an inhibitor of diabetic retinopathy".
Additionally, in the review of anti-diabetes effects of the active compounds present in the different botanical parts of burdock, researchers examined the active ingredients in the roots and seed.
The results of the chemical analysis suggested that the compounds isolated from root showed a strong effect in the inhibition of diabetes through its antioxidant activity.
In the seeds, some active compounds possess anti-inflammatory effects similar to that of arctiin treatment rats group.
These results suggested that herbal burdock exerted a strong anti-diabetes and diabetic complication through its glycaemic control and antioxidant and anti-inflammatory properties.
Taken altogether, herbal Burdock processed high numbers of the bioactive compound may be considered a functional herb for the prevention and combined with the primary medicine for the treatment of diabetes and diabetic complication.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of arctiin on streptozotocin-induced diabetic retinopathy in Sprague-Dawley rats by Lu LC, Zhou W, Li ZH, Yu CP, Li CW, Luo MH, Xie H.(PubMed)
(2) A review of the pharmacological effects of Arctium lappa (burdock) by Chan YS1, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, Leung GP, Yu PH, Chan SW. (PubMed)
(3) Fat is the Cause of Type 2 Diabetes by Written By Michael Greger M.D. FACLM on November 17th, 2016. (Nutrition Facts)
Herbal Artichoke, the Anti Hyperglycemia Natural Remedy, According to Scientists
Artichoke may process a substantial and profound effect in managing the levels of postprandial glycemia in diabetics, according to studies.
Hyperglycemia is a condition of abnormally high levels of glucose in the bloodstream.
Postprandial blood glucose is the levels taken after 2 hours of a meal, generally at the approximate peak value in patients with diabetes.
Management of postprandial blood glucose has become an important feature for diabetics against the risk of microvascular (retinopathy, nephropathy, and neuropathy) and cardiovascular disease (CVD).
Diabetes is a medical and chronic disease characterized by insufficient insulin entering the bloodstream to regulate glucose as a result of the cells in the pancreas died off or receptor sites clogged up by fat and cholesterol.
Insulin resistance is a hallmark of diabetes. The exact causes of insulin resistance are unknown. Researchers do not know why people with the same health conditions in the same family, some are susceptible to the onset of diabetes while others do not.
However, some researchers suggested that an unhealthy diet with high saturated and trans fat, red meat and processed foods is one of the major risk factors associated with the onset of the disease in the Western world compared to a traditional diet.
In other words, if you follow the Western diet, you are at an increased risk of diabetes development.
Dr. David Hefner in the concern of the risk of diabetes in patients who are fans of the Western diet wrote, "The typical Western diet-red meat, high-fat dairy products, refined grains and desserts-may increase your chances for Type 2 diabetes" and "That's what researchers at the Harvard School of Public Health have found and reported in the Annals of Internal Medicine."
The doctor continued, "The news isn't particularly shocking but offers a new view on the health risks of a typical Western diet as a whole, rather than simply attacking elements within the diet such as fatty foods".
The finding argued the risk of diabetes is reduced if you change your Western diet pattern to a traditional diet with high fruits and vegetables and whole-grain with a limited intake of saturated and trans fat, processed foods and red meat.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
With an aim to find a natural ingredient doe the treatment of hyperglycemia with no side effect, researchers examined the traditional use of artichoke (Cynara scolymus L., Asteraceae family) preparations for lowering post-prandial glycemia.
The study included non-selected Wistar and genetically obese Zucker rats treated acutely with a purified extract of Cynara scolymus flowering heads (500-1500 mg/kg by gavage) immediately prior to 1 h access to a fixed amount of food.
Any parts of Cynara scolymus flowering head extract with a lack of any fiber content have excluded.
According to the results taking at 60, 120 and 360 min after food presentation, intake of Cynara scolymus flowering head extract showed a significant decrease of postprandial glycemia in both rat groups.
The exclusion of the parts of Cynara scolymus flowering head extract with lack of any fiber content have excluded in the study suggested that the preparation induced hyperglycemic effect without involving the fiber which has been found to process a strong impact in the inhibitory activity.
Dr. Fantini N, the lead scientist wrote in the final report, "The results obtained constitute the first evidence of a hypoglycemic effect of an artichoke preparation in laboratory rodents and confirm previous observations made in humans".
In order to reveal more information about artichoke inhibited the hyperglycemic property, researchers evaluated the extract from Phaseolus vulgaris and Cynara scolymus and their combination on food intake and glycemia in rats.
The combination produced comparable reductions in intake of regular food and chocolate-flavored beverage, compared to low and ineffective to the single use of either extract.
Furthermore, P. vulgaris and C. scolymus extracts additively contributed to the reducing effect of the combination on the glycemic rise.
These results of the mixture of P. vulgaris and C. scolymus extracts was attributed to the efficacy of the anorectic effect of the P. vulgaris extract with the hypoglycemic effect of both extracts.
The findings strongly suggested that artichoke may play an important role in stimulating the mixture of antihyperglycemic activity.
Based on the results, researchers wrote, after taking into account co and confounders, "These data support the recent clinical use of the combination of P. vulgaris and C. scolymus extracts in the control of appetite, food intake, and postprandial glycemia and represent a successful example of translational research in the nutraceutical field".
Taken altogether, artichoke used alone or combined with other herbal medicine may be considered a functional remedy for the prevention and treatment of hyperglycemia, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evidence of glycemia-lowering effect by a Cynara scolymus L. extract in normal and obese rats by Fantini N1, Colombo G, Giori A, Riva A, Morazzoni P, Bombardelli E, Carai MA. (PubMed)
(2) Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymusextracts on food intake and glycemia in rats by Loi B1, Fantini N, Colombo G, Gessa GL, Riva A, Bombardelli E, Morazzoni P, Carai MA. (PubMed)
(3) Western Diet Linked to Type 2 Diabetes by David Hefner. (PMC)
Hyperglycemia is a condition of abnormally high levels of glucose in the bloodstream.
Postprandial blood glucose is the levels taken after 2 hours of a meal, generally at the approximate peak value in patients with diabetes.
Management of postprandial blood glucose has become an important feature for diabetics against the risk of microvascular (retinopathy, nephropathy, and neuropathy) and cardiovascular disease (CVD).
Diabetes is a medical and chronic disease characterized by insufficient insulin entering the bloodstream to regulate glucose as a result of the cells in the pancreas died off or receptor sites clogged up by fat and cholesterol.
Insulin resistance is a hallmark of diabetes. The exact causes of insulin resistance are unknown. Researchers do not know why people with the same health conditions in the same family, some are susceptible to the onset of diabetes while others do not.
However, some researchers suggested that an unhealthy diet with high saturated and trans fat, red meat and processed foods is one of the major risk factors associated with the onset of the disease in the Western world compared to a traditional diet.
In other words, if you follow the Western diet, you are at an increased risk of diabetes development.
Dr. David Hefner in the concern of the risk of diabetes in patients who are fans of the Western diet wrote, "The typical Western diet-red meat, high-fat dairy products, refined grains and desserts-may increase your chances for Type 2 diabetes" and "That's what researchers at the Harvard School of Public Health have found and reported in the Annals of Internal Medicine."
The doctor continued, "The news isn't particularly shocking but offers a new view on the health risks of a typical Western diet as a whole, rather than simply attacking elements within the diet such as fatty foods".
The finding argued the risk of diabetes is reduced if you change your Western diet pattern to a traditional diet with high fruits and vegetables and whole-grain with a limited intake of saturated and trans fat, processed foods and red meat.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
With an aim to find a natural ingredient doe the treatment of hyperglycemia with no side effect, researchers examined the traditional use of artichoke (Cynara scolymus L., Asteraceae family) preparations for lowering post-prandial glycemia.
The study included non-selected Wistar and genetically obese Zucker rats treated acutely with a purified extract of Cynara scolymus flowering heads (500-1500 mg/kg by gavage) immediately prior to 1 h access to a fixed amount of food.
Any parts of Cynara scolymus flowering head extract with a lack of any fiber content have excluded.
According to the results taking at 60, 120 and 360 min after food presentation, intake of Cynara scolymus flowering head extract showed a significant decrease of postprandial glycemia in both rat groups.
The exclusion of the parts of Cynara scolymus flowering head extract with lack of any fiber content have excluded in the study suggested that the preparation induced hyperglycemic effect without involving the fiber which has been found to process a strong impact in the inhibitory activity.
Dr. Fantini N, the lead scientist wrote in the final report, "The results obtained constitute the first evidence of a hypoglycemic effect of an artichoke preparation in laboratory rodents and confirm previous observations made in humans".
In order to reveal more information about artichoke inhibited the hyperglycemic property, researchers evaluated the extract from Phaseolus vulgaris and Cynara scolymus and their combination on food intake and glycemia in rats.
The combination produced comparable reductions in intake of regular food and chocolate-flavored beverage, compared to low and ineffective to the single use of either extract.
Furthermore, P. vulgaris and C. scolymus extracts additively contributed to the reducing effect of the combination on the glycemic rise.
These results of the mixture of P. vulgaris and C. scolymus extracts was attributed to the efficacy of the anorectic effect of the P. vulgaris extract with the hypoglycemic effect of both extracts.
The findings strongly suggested that artichoke may play an important role in stimulating the mixture of antihyperglycemic activity.
Based on the results, researchers wrote, after taking into account co and confounders, "These data support the recent clinical use of the combination of P. vulgaris and C. scolymus extracts in the control of appetite, food intake, and postprandial glycemia and represent a successful example of translational research in the nutraceutical field".
Taken altogether, artichoke used alone or combined with other herbal medicine may be considered a functional remedy for the prevention and treatment of hyperglycemia, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evidence of glycemia-lowering effect by a Cynara scolymus L. extract in normal and obese rats by Fantini N1, Colombo G, Giori A, Riva A, Morazzoni P, Bombardelli E, Carai MA. (PubMed)
(2) Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymusextracts on food intake and glycemia in rats by Loi B1, Fantini N, Colombo G, Gessa GL, Riva A, Bombardelli E, Morazzoni P, Carai MA. (PubMed)
(3) Western Diet Linked to Type 2 Diabetes by David Hefner. (PMC)
The Effects of Herbal Cascara Sagrada (Rhamnus purshiana) om Type 2 Diabetes
Herbal Cascara sagrada may process a strong and positive effect on reducing the risk and treatment of type 2 diabetes, according to studies.
Diabetes is a condition characterized by insulin resistance and abnormally high blood glucose. Most cases of type 2 diabetes are associated with insufficient insulin entering the bloodstream to regulate the glucose, caused by either cell in the pancreas died off or receptor sites clogged up by fat and cholesterol.
Family history, ethnicity, impaired glucose tolerance or impaired fasting glucose, high blood cholesterol and fasting glucose overweight or obese are some prevalent risk factors of the disease, according to the epidemiological studies.
Women, having gestational diabetes and polycystic ovary syndrome are also at a higher risk of diabetes.
Some researchers also suggested that aging also plays a critical role in inducing the onset of the disease, therefore, anyone over the age of 40 should be tested for diabetes every three years.
The Diabetes Society of Canada went one step further to suggest that anyone who has one or more risk factors should be tested more frequently and/or start regular screening earlier.
Truly, the clinical features of elderly diabetes are significant differences, compared to that of younger age population. Dr. Katarzyna Mordarska, the lead scientist said, "The prevalence of both type 2 diabetes and prediabetes increases with advancing age. The most important factors leading to hyperglycemia as follows deficiency of insulin secretion developing with age, and growing insulin resistance caused by a change in body composition and sarcopenia".
And, "Diabetes in elderly people is often diagnosed with a delay due to atypical symptoms (dementia, urinary incontinence) and occurrence of mainly postprandial hyperglycemia. Elderly people are more exposed to diabetes complications, have more risk of myocardial infarction and end-stage renal disease, and are hospitalized more often due to hypoglycemia than are younger patients"
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.,
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on finding natural products for the treatment of type 2 diabetes investigated the effect of emodin, a bioactive ingredient isolated from herbal Cascara Sagrada.
Emodin enhanced GLUT4 translocation and [(14)C] function in facilitating the transport of glucose across the plasma membrane of the myotube in an AMPK-dependent manner.
Where 5' AMP-activated protein kinase or AMPK is an enzyme (EC 2.7.11.31) which plays a role in activating the glucose and fatty acid uptake.
Furthermore, emodin also inhibited glucose production by suppressing the expression genes associated with key gluconeogenesis in generating glucose through sources other than carbohydrates, such as lactate, glycerol, and glucogenic amino acids.
In C57Bl/6J mice, a single dose of emodin significantly decreased the fasting plasma glucose levels and improved glucose tolerance.
According to the insulin tolerance test, the administration of emodin also increased insulin sensitivity after daily injection for 8 days.
Dr. the lead scientists said, "emodin regulates glucose homeostasis in vivo by AMPK activation and that this may represent a novel therapeutic principle in the treatment of type 2 diabetic models".
In order to reveal more information about the anti-diabetes of emodin, researchers investigated the effects of emodin on 11beta-HSD1 and its ability to ameliorate metabolic disorders in diet-induced obese (DIO) mice.
Where 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an attractive therapeutic target of type 2 diabetes and metabolic syndrome.
Emodin exerted its potency as an 11beta-HSD1 inhibitor with the IC(50) of 186 and 86 nM for human and mouse 11beta-HSD1, respectively.
Single oral administration of emodin inhibited the 11beta-HSD1 activity of liver and fat significantly in mice.
Emodin reversed prednisone-induced insulin resistance in mice, without affecting the effect of dexamethasone-induced insulin resistance, by inhibiting the 11beta-HSD1 in vivo.
In DIO mice, oral administration of emodin improved insulin sensitivity and lipid metabolism and lowered blood glucose.
The findings suggested that emodin processes the potential value for the treatment of metabolic syndrome or type 2 diabetes.
Taken altogether, herbal Cascara Sagrada with a high amount of emodin may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of type 2 diabetes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
References
(1) Emodin regulates glucose utilization by activating AMP-activated protein kinase by Song P, Kim JH, Ghim J, Yoon JH, Lee A, Kwon Y, Hyun H, Moon HY, Choi HS, Berggren PO, Suh PG, Ryu SH.(PubMed)
(2) Promotion of adiponectin multimerization by emodin: a novel AMPK activator with PPARγ-agonist activity by Chen Z, Zhang L, Yi J, Yang Z, Zhang Z, Li Z. (PubMed)
(3) Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice by Feng Y, Huang SL, Dou W, Zhang S, Chen JH, Shen Y, Shen JH, Leng Y. (PubMed)
(4) Diabetes in the elderly by Katarzyna Mordarska
1 and Małgorzata Godziejewska-Zawada. (PMC)
Diabetes is a condition characterized by insulin resistance and abnormally high blood glucose. Most cases of type 2 diabetes are associated with insufficient insulin entering the bloodstream to regulate the glucose, caused by either cell in the pancreas died off or receptor sites clogged up by fat and cholesterol.
Family history, ethnicity, impaired glucose tolerance or impaired fasting glucose, high blood cholesterol and fasting glucose overweight or obese are some prevalent risk factors of the disease, according to the epidemiological studies.
Women, having gestational diabetes and polycystic ovary syndrome are also at a higher risk of diabetes.
Some researchers also suggested that aging also plays a critical role in inducing the onset of the disease, therefore, anyone over the age of 40 should be tested for diabetes every three years.
The Diabetes Society of Canada went one step further to suggest that anyone who has one or more risk factors should be tested more frequently and/or start regular screening earlier.
Truly, the clinical features of elderly diabetes are significant differences, compared to that of younger age population. Dr. Katarzyna Mordarska, the lead scientist said, "The prevalence of both type 2 diabetes and prediabetes increases with advancing age. The most important factors leading to hyperglycemia as follows deficiency of insulin secretion developing with age, and growing insulin resistance caused by a change in body composition and sarcopenia".
And, "Diabetes in elderly people is often diagnosed with a delay due to atypical symptoms (dementia, urinary incontinence) and occurrence of mainly postprandial hyperglycemia. Elderly people are more exposed to diabetes complications, have more risk of myocardial infarction and end-stage renal disease, and are hospitalized more often due to hypoglycemia than are younger patients"
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.,
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on finding natural products for the treatment of type 2 diabetes investigated the effect of emodin, a bioactive ingredient isolated from herbal Cascara Sagrada.
Emodin enhanced GLUT4 translocation and [(14)C] function in facilitating the transport of glucose across the plasma membrane of the myotube in an AMPK-dependent manner.
Where 5' AMP-activated protein kinase or AMPK is an enzyme (EC 2.7.11.31) which plays a role in activating the glucose and fatty acid uptake.
Furthermore, emodin also inhibited glucose production by suppressing the expression genes associated with key gluconeogenesis in generating glucose through sources other than carbohydrates, such as lactate, glycerol, and glucogenic amino acids.
In C57Bl/6J mice, a single dose of emodin significantly decreased the fasting plasma glucose levels and improved glucose tolerance.
According to the insulin tolerance test, the administration of emodin also increased insulin sensitivity after daily injection for 8 days.
Dr. the lead scientists said, "emodin regulates glucose homeostasis in vivo by AMPK activation and that this may represent a novel therapeutic principle in the treatment of type 2 diabetic models".
In order to reveal more information about the anti-diabetes of emodin, researchers investigated the effects of emodin on 11beta-HSD1 and its ability to ameliorate metabolic disorders in diet-induced obese (DIO) mice.
Where 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an attractive therapeutic target of type 2 diabetes and metabolic syndrome.
Emodin exerted its potency as an 11beta-HSD1 inhibitor with the IC(50) of 186 and 86 nM for human and mouse 11beta-HSD1, respectively.
Single oral administration of emodin inhibited the 11beta-HSD1 activity of liver and fat significantly in mice.
Emodin reversed prednisone-induced insulin resistance in mice, without affecting the effect of dexamethasone-induced insulin resistance, by inhibiting the 11beta-HSD1 in vivo.
In DIO mice, oral administration of emodin improved insulin sensitivity and lipid metabolism and lowered blood glucose.
The findings suggested that emodin processes the potential value for the treatment of metabolic syndrome or type 2 diabetes.
Taken altogether, herbal Cascara Sagrada with a high amount of emodin may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of type 2 diabetes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
References
(1) Emodin regulates glucose utilization by activating AMP-activated protein kinase by Song P, Kim JH, Ghim J, Yoon JH, Lee A, Kwon Y, Hyun H, Moon HY, Choi HS, Berggren PO, Suh PG, Ryu SH.(PubMed)
(2) Promotion of adiponectin multimerization by emodin: a novel AMPK activator with PPARγ-agonist activity by Chen Z, Zhang L, Yi J, Yang Z, Zhang Z, Li Z. (PubMed)
(3) Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice by Feng Y, Huang SL, Dou W, Zhang S, Chen JH, Shen Y, Shen JH, Leng Y. (PubMed)
(4) Diabetes in the elderly by Katarzyna Mordarska
1 and Małgorzata Godziejewska-Zawada. (PMC)
Saturday, January 4, 2020
Aloe Vera, the Natural Antioxidant Whole Food
Aloe Vera has shown to express to the antibacterial infection and scavenging properties with the rate of over 75% compared to ascorbic acid (92%) a renowned institute suggested.
Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorroeaceae, native to Sudan used in herbal medicine in treating many kinds of diseases, including wound and burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. The plant is very popular for commercial cultivation due to its health benefits,
Antioxidants are the set of molecules with functions in binding the production of free radicals causes of oxidative stress to the body and fighting against the invasion of bacterial organisms.
According to Monash University Malaysia, Aloe vera bioactive compounds exerted inhibited effects against numbers of bacterial strands, particular in Bacillus (20.7%), Pseudomonas (20.7%) and Enterobacter (13.8%).
Dr. Akinsanya MA, the lead author in the joint study suggested that the efficacy of Aloe Vera is the result of the production of bioactive compounds with high DPPH, (an organic chemical compound with) scavenging properties (75-88%).
In fact, in vitro, the testing various phytochemicals such as total phenolic content antioxidant activity, A. vera methanolic leaf extracts exhibited a strong antioxidant activity in free radical scavenging assay, metal chelating assay, hydrogen peroxide scavenging assay.
Although, Aloe Vera may have significant antioxidant property different agro-climatic conditions may affect the total phenolic content (TPC) and antioxidant potential of the plant.
The findings that Aloe Vera has exerted the antioxidant effects in various aspects, but intake of the large amounts should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Diversity, antimicrobial and antioxidant activities of culturable bacterial endophyte communities in Aloe vera by Akinsanya MA1, Goh JK2, Lim SP2, Ting AS3.(PubMed)
(2) Effect of climate change on phytochemical diversity, total phenolic content and in vitro antioxidant activity of Aloe vera (L.) Burm.f by Kumar S1, Yadav A1, Yadav M1, Yadav JP2.(PubMed)
Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorroeaceae, native to Sudan used in herbal medicine in treating many kinds of diseases, including wound and burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. The plant is very popular for commercial cultivation due to its health benefits,
Antioxidants are the set of molecules with functions in binding the production of free radicals causes of oxidative stress to the body and fighting against the invasion of bacterial organisms.
According to Monash University Malaysia, Aloe vera bioactive compounds exerted inhibited effects against numbers of bacterial strands, particular in Bacillus (20.7%), Pseudomonas (20.7%) and Enterobacter (13.8%).
Dr. Akinsanya MA, the lead author in the joint study suggested that the efficacy of Aloe Vera is the result of the production of bioactive compounds with high DPPH, (an organic chemical compound with) scavenging properties (75-88%).
In fact, in vitro, the testing various phytochemicals such as total phenolic content antioxidant activity, A. vera methanolic leaf extracts exhibited a strong antioxidant activity in free radical scavenging assay, metal chelating assay, hydrogen peroxide scavenging assay.
Although, Aloe Vera may have significant antioxidant property different agro-climatic conditions may affect the total phenolic content (TPC) and antioxidant potential of the plant.
The findings that Aloe Vera has exerted the antioxidant effects in various aspects, but intake of the large amounts should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Diversity, antimicrobial and antioxidant activities of culturable bacterial endophyte communities in Aloe vera by Akinsanya MA1, Goh JK2, Lim SP2, Ting AS3.(PubMed)
(2) Effect of climate change on phytochemical diversity, total phenolic content and in vitro antioxidant activity of Aloe vera (L.) Burm.f by Kumar S1, Yadav A1, Yadav M1, Yadav JP2.(PubMed)
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