Scientists may have found a natural herb, namely Cat's claw in suppressing the onset of osteoarthritis without inducing any adverse effects, some studies suggested
An osteoarthritis is a group of diseases involved progressive degeneration of joints, including articular cartilage and subchondral bone.
According to statistic, osteoarthritis(OA) is one of the most common forms of arthritis disorder, affecting adults 60 years of age or older in the United States.
Approximately, over 25 million of US population who are adults 60 years of age or older are infected by symptomatic knee OA, including 10% of men and 13% of women.
However, according to University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in the knee, hip and hand joints.
Conventional medicine, today in the management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments without mentioning how to cure the disease.
There is evidence suggested that the disease is associated with the inflammation, breakdown, and eventual loss of cartilage in the joints. But what causes the chronic inflammatory of osteoarthritis is debatable?
Some researchers suggested that the process of wear and repair, nutrient deficiency,......and overload and damage of cartilage due to aging or damage are the possible actually cause of osteoarthritis.
The severity symptoms of osteoarthritis, according to experts include pain in joints of the hand, knee and hip and spine. If you experience the above symptoms, you may already have osteoarthritis.
.Cat's claw found in in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The specific herbal medicine has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
Chemical constituents
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchona, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
In the study to understand the effect of Cat's claw isolated active compounds against the pivotal molecular targets involved in inflammation and the joint destruction process and in summarized their 's claw toxicities and efficacy, researchers at the Case Western Reserve University, showed that application of herbal Cat's claw exerts a positive effect in alleviation pain with no adverse effect(1).
Dr. Akhtar N, the lead author after taking account of other co and confounders said, " (Although) Limited in vitro and in vivo evidence is available for cat's claw and Indian olibanum,... There is strong clinical evidence of the effectiveness of devil's claw in pain reduction" and " No serious side effects have been reported for any..... herbs" (1).
According to the study of "Devil's claw extract as an example of the effectiveness of herbal analgesics", Doloteffin (extraction solvent water) a botany herbal preparation included extracted with 60% ethanol of Cat's claw have a proven effectiveness similar to those of conventional painkiller or synthetic analgesics for treatment painful lower back or arthritic pain(2)..
Dr. Chrubasik S. at Institut für Rechtsmedizin der Universität Freiburg, said, " From an evidence-based view, extract with at least 50 mg harpagoside in the daily dose should be recommended for the treatment of pain" and "Treatment with devil's claw extract is associated with a lower risk of adverse events than treatment with synthetic analgesics, and may contribute in the majority of patients to the relief of pain"(2).
This effectiveness may coincide with the use of the herb in herbal medicine for thousands of year in treating disorders such as arthritis, gastritis, and osteoarthritis(3).
Truly, The mechanisms of cat's claw in the treatment of osteoarthritis were attributed to the antioxidants and its inhibition of TNF-alpha.
Tumor necrosis factor α is a cell signaling protein (cytokine) involved systemic inflammation that protects our body against foreign organism infection in acute phase reaction.
Unfortunately, the study in reviews the database by the University of Southampton, raised the question of the methodological quality of the existing clinical trials and suggested that clinical evidence to date cannot provide a definitive answer to the two questions posed, although these trials may provide certain supports for the effectiveness of the herb(4).
* Does it work?
* And (2) is it safe?
Taking all together, Cat's claw may have a profound and substantial effect similar to those of conventional medicine such as acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs). Aspirin, naproxen (Aleve), and ibuprofen in ameliorated osteoarthritis pain with little or no side effects(3).
However, intake of Cat's claw supplement only is prescribed by herbalists as an overdose may cause acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Current nutraceuticals in the management of osteoarthritis: a review by Akhtar N1, Haqqi TM. (PubMed)
(2) [Devil's claw extract as an example of the effectiveness of herbal analgesics].[Article in German]
by Chrubasik S.(PubMed)
(3) Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis by Hardin SR.(PubMed)
(4) Devil's Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety by Brien S1, Lewith GT, McGregor G.(PubMed)
(5) Osteoarthritis by Kyle J. Norton
Monday, January 20, 2020
Regular Walking Reduces risk of Diabetes Complications in older Adult and Early onset of Diabetes
Regular physical activity has long been found to associate with the prevention of cancer, cardiovascular disease, and other chronic diseases, but the regular walking contribution of the health benefits of the younger elderly has not been explored.
According to the Catholic University of Daegu, implementing a regular walking and exercise program in older adult reduce the incidence of type II diabetes complications, through expressions of physical strength, and energy consumption (behavioral aspects), and decreased FBG, HbA1c, and TG levels (biochemical aspects(1).
In the review of Three databases, searched up to August 2014 of Eighteen studies involving 20 RCTs (866 participants) among type 2 diabetes patients, regular walking not only supported the decrease of HbA1c and BMI but also lowered the DBP among type 2 diabetes patients(2).
Dr. Fritz T and colleagues at the Center of Family Medicine, Karolinska Institutet said, "increase of regular physical activity equivalent to 45 min of walking 3 days/week may suffice to improve systolic and diastolic blood pressure, lipid metabolism and BMI "(3); improvement of plasma protein concentrations that promote blood hyperviscosity(4) and on cardiovascular risk factors and body composition in normoglycemic in patients with type 2 diabetes(5)
In fact, regular exercise not only reduces complications of types 2 diabetes in the older adult(1)(2)(3) but also prevents the early onset of the disease, due to its effect on the reduced prevalence of hyperglycemia and improved glycaemic control(9). According to Dr. Thyfault JP and Dr. Booth FW, physical inactivity (bed rest, increased sitting time, and reduced daily ambulatory activity), increases the risk of metabolic dysfunctions in contribution to the development of obesity and type 2 diabetes(6).
Physical inactivity, in sedentary behaviors, especially sitting may have a major impact on mortality, cardiovascular disease, type 2 diabetes, metabolic syndrome risk factors, and obesity as a result of inactivity initiated unique cellular processes involved metabolically unfit(7) of which may contribute to early-onset diabetes.
Dr. Thyfault JP and Dr. Krogh-Madsen R.at the University of Missouri said, ' The transition from physical activity to inactivity may result in insulin sensitivity, central adiposity, and risk of chronic disease(8).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of a regular walking exercise program on behavioral and biochemical aspects in elderly people with type II diabetes by Sung K1, Bae S.(PubMed)
(2) Impact of walking on glycemic control and other cardiovascular risk factors in type 2diabetes: a meta-analysis by Qiu S1, Cai X2, Schumann U3, Velders M3, Sun Z2, Steinacker JM3(PubMed)
(3) Walking for exercise--does three times per week influence risk factors in type 2 diabetes? BY Fritz T1, Wändell P, Aberg H, Engfeldt P.(PubMed)
(4) Regular walking improves plasma protein concentrations that promote blood hyperviscosity in women 65-74 yr with type 2 diabetes by Simmonds MJ1,2, Sabapathy S1,2, Serre KR3, Haseler LJ1,2, Gass GC3, Marshall-Gradisnik SM1, Minahan CL1,2.(PubMed)
(5) Effects of regular walking on cardiovascular risk factors and body composition in normoglycemic women and women with type 2 diabetes. by Walker KZ1, Piers LS, Putt RS, Jones JA, O'Dea K(PubMed)
(6) Lack of regular physical exercise or too much inactivity. by Thyfault JP1, Booth FW.(PubMed)
(7) Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease by Hamilton MT1, Hamilton DG, Zderic TW.(PubMed)
(8) Metabolic disruptions induced by reduced ambulatory activity in free-living humans by Thyfault JP1, Krogh-Madsen R.(PubMed)
(9) Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients by van Dijk JW1, Manders RJ, Tummers K, Bonomi AG, Stehouwer CD, Hartgens F, van Loon LJ.(PubMed)
According to the Catholic University of Daegu, implementing a regular walking and exercise program in older adult reduce the incidence of type II diabetes complications, through expressions of physical strength, and energy consumption (behavioral aspects), and decreased FBG, HbA1c, and TG levels (biochemical aspects(1).
In the review of Three databases, searched up to August 2014 of Eighteen studies involving 20 RCTs (866 participants) among type 2 diabetes patients, regular walking not only supported the decrease of HbA1c and BMI but also lowered the DBP among type 2 diabetes patients(2).
Dr. Fritz T and colleagues at the Center of Family Medicine, Karolinska Institutet said, "increase of regular physical activity equivalent to 45 min of walking 3 days/week may suffice to improve systolic and diastolic blood pressure, lipid metabolism and BMI "(3); improvement of plasma protein concentrations that promote blood hyperviscosity(4) and on cardiovascular risk factors and body composition in normoglycemic in patients with type 2 diabetes(5)
In fact, regular exercise not only reduces complications of types 2 diabetes in the older adult(1)(2)(3) but also prevents the early onset of the disease, due to its effect on the reduced prevalence of hyperglycemia and improved glycaemic control(9). According to Dr. Thyfault JP and Dr. Booth FW, physical inactivity (bed rest, increased sitting time, and reduced daily ambulatory activity), increases the risk of metabolic dysfunctions in contribution to the development of obesity and type 2 diabetes(6).
Physical inactivity, in sedentary behaviors, especially sitting may have a major impact on mortality, cardiovascular disease, type 2 diabetes, metabolic syndrome risk factors, and obesity as a result of inactivity initiated unique cellular processes involved metabolically unfit(7) of which may contribute to early-onset diabetes.
Dr. Thyfault JP and Dr. Krogh-Madsen R.at the University of Missouri said, ' The transition from physical activity to inactivity may result in insulin sensitivity, central adiposity, and risk of chronic disease(8).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of a regular walking exercise program on behavioral and biochemical aspects in elderly people with type II diabetes by Sung K1, Bae S.(PubMed)
(2) Impact of walking on glycemic control and other cardiovascular risk factors in type 2diabetes: a meta-analysis by Qiu S1, Cai X2, Schumann U3, Velders M3, Sun Z2, Steinacker JM3(PubMed)
(3) Walking for exercise--does three times per week influence risk factors in type 2 diabetes? BY Fritz T1, Wändell P, Aberg H, Engfeldt P.(PubMed)
(4) Regular walking improves plasma protein concentrations that promote blood hyperviscosity in women 65-74 yr with type 2 diabetes by Simmonds MJ1,2, Sabapathy S1,2, Serre KR3, Haseler LJ1,2, Gass GC3, Marshall-Gradisnik SM1, Minahan CL1,2.(PubMed)
(5) Effects of regular walking on cardiovascular risk factors and body composition in normoglycemic women and women with type 2 diabetes. by Walker KZ1, Piers LS, Putt RS, Jones JA, O'Dea K(PubMed)
(6) Lack of regular physical exercise or too much inactivity. by Thyfault JP1, Booth FW.(PubMed)
(7) Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease by Hamilton MT1, Hamilton DG, Zderic TW.(PubMed)
(8) Metabolic disruptions induced by reduced ambulatory activity in free-living humans by Thyfault JP1, Krogh-Madsen R.(PubMed)
(9) Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients by van Dijk JW1, Manders RJ, Tummers K, Bonomi AG, Stehouwer CD, Hartgens F, van Loon LJ.(PubMed)
Sunday, January 19, 2020
Detoxification: What Are The External Causes of Toxins Accumulated in Our Body?
The human body has adapted to the change of environment over thousands of years by properly responding to external conditions. The lymphatic system expressed its function when the body is cold by secreting sweat through the skin and the cells send signals to request for water when the body is dehydration.
However, when the body no longer can adjust to long-term toxins accumulation, the signs of discomfort and disease appear, leading to symptoms of a headache, fever, nausea, vomiting,...... and diarrhea.
Toxins are chemical agents if overwhelm the body tissue can cause dysfunction of the internal organs, leading to overexpression of free radicals in the induction of chronic diseases.
Symptoms of toxic organs share a similar trail with biological agents such as bacteria or viruses.
To better understand how the disease is caused by exposure to toxic chemicals, we must first understand how poisons work within the body.
According to the joint article of " Manifestations of Toxic Effects" lead by the Cornell University, researchers wrote, "Toxicity is normally divided into four types, based on the number of exposures to poison and the time it takes for toxic symptoms to develop. The two types most often referred to are acute and chronic" and " Most toxic effects are reversible and do not cause permanent damage, but complete recovery may take a long time. However, some poisons cause irreversible (permanent) damage".(1)
Here are the most common external causes of toxin accumulation in the body
1. Air Pollution
The cause of air pollution is the result of the burning of fossil fuels such as coal, oil, natural gas, and gasoline to produce electricity and power our vehicles such as the emitting of carbon dioxide resulting in ozone pollution, acid rain, and toxic heavy metal pollution.
In the study of environmental pollution, Dr. Marilena, the lead author wrote in Volume 151, Issue 2, January 2008, Pages 362-367, "Air pollution has both acute and chronic effects on human health, affecting a number of different systems and organs. It ranges from minor upper respiratory irritation to chronic respiratory and heart disease, lung cancer, acute respiratory infections in children and chronic bronchitis in adults, aggravating pre-existing heart and lung disease, or asthmatic attacks" and "In addition, short- and long-term exposures have also been linked with premature mortality and reduced life expectancy".
Yes, this is the air we breathe every day. Every breath we inhale, our body is required to detoxify all this harmful material entering our body.
If the body systems (circulatory, digestive, endocrine, excretory, immune, integumentary, muscular, nervous, reproductive, respiratory, and skeletal) are weakened, some of these harmful cannot be removed from our body that can cause heavy metal accumulation and disrupt the normal function of organs and lead to inflammation and infection.
2. Soil Pollution
Soil pollution is caused by misuse of the soil in poor agricultural practices, mineral exploitation, industrial waste dumping, and indiscriminate disposal of urban wastes.
These kinds of wastes accumulating in our soil include herbicides, pesticides, heavy metals and man-made chemicals that will enter our body through raining, snowing and foods.
Dr. Sónia M.Rodrigues and Dr. Paul F.A.M.Römkens, the scientists expressed in the Chapter 9 - Human Health Risks and Soil Pollution, " Accumulation of toxic chemical pollutants and soil-borne pathogens in soils resulted in increased human exposure either via inhalation, dermal contact or ingestion of soil, or indirect exposure via dietary intake or drinking water" and " It is, therefore, crucial to develop tools to assess potential risks of human exposure to pollutants and to determine meaningful threshold concentrations in soils in order to protect human health"(3).
Long-term accumulation of these harmful substances will disable the body system, leading to the development of chronic diseases.
3. Water pollution
An estimated 90% of wastewater is discharged directly into rivers and streams without treatment.
According to the reports by CBC, "More than 205 billion liters of raw sewage and untreated wastewater spewed into Canada's rivers and oceans last year, CBC News has learned, despite federal regulations introduced in 2012 to try to solve the problem"(4).
Other causes of water pollution include poorly designed landfills, road deicing salts, and hazardous waste sites, these harmful substances of heavy metals and chemical substances can enter the water that we drink every day.
4. Indoor pollution
Indoor pollution such as gas heaters, gas appliances, wood burning fireplaces, leaking chimneys and furnaces, and tobacco smoke causes allergic reactions such as eye, nose and throat irritation, and weakening our immune system.
According to the book of Indoor Pollution charter VII health effects of indoor pollution, " Pollutants are inhaled, ingested, and absorbed. They may have effects at their first point of contact with the body, or they may affect internal organs" and "( In compared to injection and absorption) Inhalation is generally the most important route by which toxic substances enter the body. Inhaled substances may exert their effects in the lungs, or they may pass from the lungs to other organ systems in blood, lymph, etc"(5).
5. Toxins in Food
Certain foods are more toxic than others, such as french fries, BBQ chicken, and most fast foods which contain a high quantity of trans-fat that has been shown to be carcinogenic. Fruits and vegetables that grow in the contaminated soils or herbicides used on them, will absorb the contamination substances.
People who have an occupation in dealing with natural food toxins may cause toxins accumulated in the body. The WHO in the article of food fact, wrote, "Some natural toxins can be formed in food as defense mechanisms of plants, through their infestation with toxin-producing mold, or through ingestion by animals of toxin-producing microorganisms." and "Long-term health consequences include effects on the immune, reproductive or nervous systems, and also cancer"(6).
Also, Stacy Kennedy, MPH, RD, CSO, LDN; Reboot Nutritionist in the article of 5 Chemicals That Turn Our Food Toxic (and how to avoid them!) suggested Bisphenol-A, aka “BPA.”, the estrogen-like man-made chemical is pervasive in canned foods; Bromated Vegetable Oil, aka “BVO.”, the chemical enhances the bright colors in many bottled beverages like soda, sports drinks, and citrus-flavored drinks; Benzoate Preservatives, aka “BHT, BHA, TBHQ.”, the chemicals are used to help keep fats in foods from going rancid; Perfluorooctanoic acid, aka “PFOA.”, the paper and lining of microwave popcorn bags contain PFOA and Azodicarbonamide, the bleaching agent used in packaged, processed foods like frozen dinners, pasta and flour mixes in baked goods(7)..
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Manifestations of Toxic Effects by Cornell University, Michigan State University, Oregon State University, and University of California at Davis
(2) Human health effects of air pollution by Marilena Kampa and Elias Castanas
(3) the scientists expressed in the Chapter 9 - Human Health Risks and Soil Pollution by Dr. Sónia M.Rodrigues and Dr. Paul F.A.M.Römkens,
(4) Billions of litres of raw sewage, untreated waste water pouring into Canadian waterways by Elizabeth Thompson ·
(5) Indoor Pollution charter VII health effects of indoor pollution
(6) Natural toxins in food(WHO)
(7) Stacy Kennedy, MPH, RD, CSO, LDN; Reboot Nutritionist in the article of 5 Chemicals That Turn Our Food Toxic (and how to avoid them!)
Ginger, the Pungent Spice Which inhibits the Onset and Progression of Arthritis
Scientists may have found a whole food which processes a significant effect in reducing and treatment of arthritis with no side effects, some studies found.
Arthritis is a class of inflammatory diseases that affect the joints.
The most common symptoms of arthritis are joint pain and stiffness.
However, some patients with arthritis may also experience symptoms of redness, warmth, swelling, and decreased range of motion of the affected joints.
The most common causes of arthritis are the improper health of the joint injury in the younger age and infections that affect the integrity of the cartilage.
RA, an autoimmune disorder is a type of arthritis caused by the immune system mistakenly attacks the joints tissues of the body.
The prevalent risk factors associated with the onset of the disease include the increase in age, family history, gender, ethnicity, and obesity.
Some researchers suggested that people who follow the Western diet with high saturated and trans fat, red meat and processed foods and fewer fruits and vegetables and whole grains are also at the increased risk of arthritis.
According to the study published in the journal JCI Insight on April 19, by the University of Rochester Medical Center in New York, after 3 months of feeding mice a high-fat diet similar to that of a western “cheeseburger and milkshake” regimen, the mice became obese and diabetic and fat percentage was double compared to mice fed with a healthy, low-fat diet.
The contribution of overweight obesity caused by long-term intake of the Western diet may contribute to the link of obesity in the risk of arthritis.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to reconfirm the traditional medicine use of ginger for the treatment of chronic inflammatory diseases, the research team at the examine the turmeric (rich in curcuminoids) and ginger (rich in gingerols and shogaols) rhizomes effect in patients with arthritis rat adjuvant-induced arthritis (AIA) both plants at the dose 200 mg/kg body weight were orally administrated.
Turmeric and ginger exerted a significantly suppressed (but with different degrees) the incidence and severity of arthritis by increasing the production of anti-inflammatory and decreasing pro-inflammatory cytokines.
Both turmeric and ginger also restored the antioxidant enzymes in the rats.
In the anti-arthritic activity, turmeric was more effective compared to those of ginger and indomethacin (a non-steroidal anti-inflammatory drug), especially when the treatment started from the day of arthritis induction.
Interestingly, the percentage of disease recovery was 4.6-8.3% and 10.2% more in turmeric compared with ginger and indomethacin, respectively.
Dr. the lead author said, after taking into account of co and confounders, "the anti-inflammatory/anti-oxidant activity of turmeric over ginger and indomethacin, which may have beneficial effects against rheumatoid arthritis onset/progression as shown in AIA rat model".
The findings indicated a potential effect of ginger against arthritis although to a lesser extent than those of turmeric.
Furthermore, the investigation of the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) in ameliorating inflammatory process in rat collagen-induced arthritis, also found that* Z. officinale extract in doses higher than 50 mg/kg/day intraperitoneally significantly enhanced the immune function against the progression of arthritis.
* Continued administration of the said volume for 26 days can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction.
* The anti-arthritis effects were associated with reduced production of proinflammatory cytokines and antibody.
Most importantly, Z. officinale extract at the dose of 200 mg/kg/day was more superior to those of 2 mg/kg/day of indomethacin compared by most of the measured parameters.
Taken altogether, ginger may be used as a functional food for the prevention and combined with primary medicine for the treatment of arthritis
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis by Ramadan G1, Al-Kahtani MA, El-Sayed WM. (PubMed)
(2) Evaluation of the effect of hydroalcoholic extract of Zingiber officinale rhizomes in rat collagen-induced arthritis by Fouda AM1, Berika MY. (PubMed)
(3) Western Diet, With Its High-Fat Content, Linked To ArthritisApr 19, 2018 09:00 AM By Sadhana Bharanidharan, (Medical Daily)
Arthritis is a class of inflammatory diseases that affect the joints.
The most common symptoms of arthritis are joint pain and stiffness.
However, some patients with arthritis may also experience symptoms of redness, warmth, swelling, and decreased range of motion of the affected joints.
The most common causes of arthritis are the improper health of the joint injury in the younger age and infections that affect the integrity of the cartilage.
RA, an autoimmune disorder is a type of arthritis caused by the immune system mistakenly attacks the joints tissues of the body.
The prevalent risk factors associated with the onset of the disease include the increase in age, family history, gender, ethnicity, and obesity.
Some researchers suggested that people who follow the Western diet with high saturated and trans fat, red meat and processed foods and fewer fruits and vegetables and whole grains are also at the increased risk of arthritis.
According to the study published in the journal JCI Insight on April 19, by the University of Rochester Medical Center in New York, after 3 months of feeding mice a high-fat diet similar to that of a western “cheeseburger and milkshake” regimen, the mice became obese and diabetic and fat percentage was double compared to mice fed with a healthy, low-fat diet.
The contribution of overweight obesity caused by long-term intake of the Western diet may contribute to the link of obesity in the risk of arthritis.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to reconfirm the traditional medicine use of ginger for the treatment of chronic inflammatory diseases, the research team at the examine the turmeric (rich in curcuminoids) and ginger (rich in gingerols and shogaols) rhizomes effect in patients with arthritis rat adjuvant-induced arthritis (AIA) both plants at the dose 200 mg/kg body weight were orally administrated.
Turmeric and ginger exerted a significantly suppressed (but with different degrees) the incidence and severity of arthritis by increasing the production of anti-inflammatory and decreasing pro-inflammatory cytokines.
Both turmeric and ginger also restored the antioxidant enzymes in the rats.
In the anti-arthritic activity, turmeric was more effective compared to those of ginger and indomethacin (a non-steroidal anti-inflammatory drug), especially when the treatment started from the day of arthritis induction.
Interestingly, the percentage of disease recovery was 4.6-8.3% and 10.2% more in turmeric compared with ginger and indomethacin, respectively.
Dr. the lead author said, after taking into account of co and confounders, "the anti-inflammatory/anti-oxidant activity of turmeric over ginger and indomethacin, which may have beneficial effects against rheumatoid arthritis onset/progression as shown in AIA rat model".
The findings indicated a potential effect of ginger against arthritis although to a lesser extent than those of turmeric.
Furthermore, the investigation of the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) in ameliorating inflammatory process in rat collagen-induced arthritis, also found that* Z. officinale extract in doses higher than 50 mg/kg/day intraperitoneally significantly enhanced the immune function against the progression of arthritis.
* Continued administration of the said volume for 26 days can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction.
* The anti-arthritis effects were associated with reduced production of proinflammatory cytokines and antibody.
Most importantly, Z. officinale extract at the dose of 200 mg/kg/day was more superior to those of 2 mg/kg/day of indomethacin compared by most of the measured parameters.
Taken altogether, ginger may be used as a functional food for the prevention and combined with primary medicine for the treatment of arthritis
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis by Ramadan G1, Al-Kahtani MA, El-Sayed WM. (PubMed)
(2) Evaluation of the effect of hydroalcoholic extract of Zingiber officinale rhizomes in rat collagen-induced arthritis by Fouda AM1, Berika MY. (PubMed)
(3) Western Diet, With Its High-Fat Content, Linked To ArthritisApr 19, 2018 09:00 AM By Sadhana Bharanidharan, (Medical Daily)
Regular Walking Reduces Symptoms and Risk of Polymyalgia Rheumatica
Regular physical activity has long been found to associate with the prevention of cancer, cardiovascular disease, and other chronic diseases, but the regular walking contribution of the health benefits of Polymyalgia Rheumatica in the younger and older elderly have been controversial.
Polymyalgia Arthritis is a condition a common inflammatory rheumatic disease causing pain, stiffness, and tenderness in large muscles, including muscle shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.
According to the Saint-André Hospital, Bordeaux Teaching Hospital, there has been a report of 2 cases of inflammatory arterial lesions of the lower limbs as results of intermittent claudication with a walking distance of only 30 m(1).
But regular walking has shown. to improve immunity against inflammation(2), through reduction of oxidative stress(4) and production of inflammatory cytokines (reduction in the ratio of plasma IL-6 to IL-10 levels)(3), through improved immune and inflammatory responses(3).
Dr. Dopheide JF and colleagues at the University Medical Center of the Johannes Gutenberg-University Mainz said, "a reduced inflammatory state might be achieved by regular walking exercise" and " amelioration of the proinflammatory phenotype"(2)
Walking caused modest and short-lived changes in immune parameters, most notably for neutrophil and natural killer blood cell counts through increased oxygen consumption(6).
In fact, regular exercise, including walking affecting the levels of inflammatory cytokine can contribute to guide clinical practice related to treatment and prevention of functional changes due to chronic inflammatory activity in older adults(4).
A total of 297 healthy adults ages 50-79 years with no history of knee injury or disease recruited from an existing study on healthy aging, insisted, regular walking reduces the risk of bone marrow lesions in the knee. and maybe a beneficial effect of physical activity for diseases associated with aging and exercise that is good for the heart is also good for the knees(5).
The Medical Disability Advisor in the evaluation of Polymyalgia Rheumatica suggested that patients with Polymyalgia Rheumatica should have developed a realistic and comprehensive program of walking, aquatic exercise, stretching, and strengthening exercises(7).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) Giant cell arteritis involving the lower limbs by Dupuy R1, Mercié P, Neau D, Longy-Boursier M, Conri C.(PubMed)
(2) Change of walking distance in intermittent claudication: impact on inflammation, oxidative stress and mononuclear cells: a pilot study by Dopheide JF1, Scheer M, Doppler C, Obst V, Stein P, Vosseler M, Abegunewardene N, Gori T, Münzel T, Daiber A, Radsak MP, Espinola-Klein C.(PubMed)
(3) Evidence for anti-inflammatory effects of exercise in CKD BY Viana JL1, Kosmadakis GC2, Watson EL3, Bevington A3, Feehally J2, Bishop NC4, Smith AC5.(PubMed)
(4) Interaction between cytokine gene polymorphisms and the effect of physical exercise on clinical and inflammatory parameters in older women: study protocol for a randomized controlled trial. by Pereira DS1, Queiroz BZ, Mateo EC, Assumpção AM, Felício DC, Miranda AS, Anjos DM, Jesus-Moraleida F, Dias RC, Pereira DA,Teixeira AL, Pereira LS.(PubMed)
(5) Effect of physical activity on articular knee joint structures in community-based adults.Racunica TL1, Teichtahl AJ, Wang Y, Wluka AE, English DR, Giles GG, O'Sullivan R, Cicuttini FM.(PubMed)
(6) Immune response to a 30-minute walk by Nieman DC1, Henson DA, Austin MD, Brown VA.(PubMed)
(7) Medical Disability Advisor > Polymyalgia Rheumatica(GMD Guideline)
Polymyalgia Arthritis is a condition a common inflammatory rheumatic disease causing pain, stiffness, and tenderness in large muscles, including muscle shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.
According to the Saint-André Hospital, Bordeaux Teaching Hospital, there has been a report of 2 cases of inflammatory arterial lesions of the lower limbs as results of intermittent claudication with a walking distance of only 30 m(1).
But regular walking has shown. to improve immunity against inflammation(2), through reduction of oxidative stress(4) and production of inflammatory cytokines (reduction in the ratio of plasma IL-6 to IL-10 levels)(3), through improved immune and inflammatory responses(3).
Dr. Dopheide JF and colleagues at the University Medical Center of the Johannes Gutenberg-University Mainz said, "a reduced inflammatory state might be achieved by regular walking exercise" and " amelioration of the proinflammatory phenotype"(2)
Walking caused modest and short-lived changes in immune parameters, most notably for neutrophil and natural killer blood cell counts through increased oxygen consumption(6).
In fact, regular exercise, including walking affecting the levels of inflammatory cytokine can contribute to guide clinical practice related to treatment and prevention of functional changes due to chronic inflammatory activity in older adults(4).
A total of 297 healthy adults ages 50-79 years with no history of knee injury or disease recruited from an existing study on healthy aging, insisted, regular walking reduces the risk of bone marrow lesions in the knee. and maybe a beneficial effect of physical activity for diseases associated with aging and exercise that is good for the heart is also good for the knees(5).
The Medical Disability Advisor in the evaluation of Polymyalgia Rheumatica suggested that patients with Polymyalgia Rheumatica should have developed a realistic and comprehensive program of walking, aquatic exercise, stretching, and strengthening exercises(7).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) Giant cell arteritis involving the lower limbs by Dupuy R1, Mercié P, Neau D, Longy-Boursier M, Conri C.(PubMed)
(2) Change of walking distance in intermittent claudication: impact on inflammation, oxidative stress and mononuclear cells: a pilot study by Dopheide JF1, Scheer M, Doppler C, Obst V, Stein P, Vosseler M, Abegunewardene N, Gori T, Münzel T, Daiber A, Radsak MP, Espinola-Klein C.(PubMed)
(3) Evidence for anti-inflammatory effects of exercise in CKD BY Viana JL1, Kosmadakis GC2, Watson EL3, Bevington A3, Feehally J2, Bishop NC4, Smith AC5.(PubMed)
(4) Interaction between cytokine gene polymorphisms and the effect of physical exercise on clinical and inflammatory parameters in older women: study protocol for a randomized controlled trial. by Pereira DS1, Queiroz BZ, Mateo EC, Assumpção AM, Felício DC, Miranda AS, Anjos DM, Jesus-Moraleida F, Dias RC, Pereira DA,Teixeira AL, Pereira LS.(PubMed)
(5) Effect of physical activity on articular knee joint structures in community-based adults.Racunica TL1, Teichtahl AJ, Wang Y, Wluka AE, English DR, Giles GG, O'Sullivan R, Cicuttini FM.(PubMed)
(6) Immune response to a 30-minute walk by Nieman DC1, Henson DA, Austin MD, Brown VA.(PubMed)
(7) Medical Disability Advisor > Polymyalgia Rheumatica(GMD Guideline)
Soy and Prostate Cancer in Japanese Men
Soybean is the genus Glycine, belonging to the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with a suitable climate for commercial profits.
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein
I. Soy in Eastern population
A. The Japanese population
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years of healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b).
A3. Soy and Prostate cancer in Japanese Men
Prostate cancer is defined as a condition in which the cells of the prostate has become cancerous, causing abnormal cell growth with the possibility of spreading to the distant parts of the body. Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.
The widespread of prostate cancer, once considered a disease of aging male, now have become major concerns of governments and scientific community in South East Asian with a tendency to affect even younger age population. Suggestions emerged of over-consuming bad fats at any time in history accompanied by an unhealthy diet and lifestyle may be the possible causes of the disease, linking to the economic prosperity over 2 decades.
In fact, the incidence of prostate cancer in Asia is still lower if compared to their Western counterparts.
The Research Center for Cancer Prevention and Screening, National Cancer Center. suggested that isoflavones and soy food are associated with a dose-dependent decrease in the reduced risk of localized cancer, in a population-based prospective study in 43,509 Japanese men ages 45 to 74 years with participants responded to a validated questionnaire, which included 147 food items. During follow-up from 1995 through 2004, 307 men were newly diagnosed with prostate cancer, of which 74 cases were advanced, 220 cases were organ localized, and 13 cases were of an undetermined stage(5).
Environment, Diet, intestinal microbiota and Geography
The testing of North American Japanese and Japanese in Japan showed the environment factor may be involved in the development of prostate cancer regardless of genetic similarity(7). The incidence of the disease increased vary both from country to country and ethnic group, with the highest incidence reported for Afro-Americans and the lowest for Asian men(2).
The study of the associations between nutritional and other lifestyle factors and the prevalence of prostate cancer in a case-control study of Japanese men showed that soy isoflavone significantly decreased the risk of prostate cancer regardless of the intake of other nutrients such as PUFA, (n-6) fatty acids or magnesium from other food sources(9).
Others suggested that legumes (not limited to soy products) and certain categories of vegetables may protect against prostate cancer(10).
DR. Akaza H. said "not having equol converting bacteria in the intestine (non-equol producers) can be a risk factor for prostate cancer and that one direction for future research will be to examine the possibility of improving the intestinal environment to enable equol production"(13).
Genes differentiation
1n gene differentiation, estrogen-related genes may be the culprits for the development of prostate cancer. In one hundred and eighty cases and 177 controls selected from three geographic areas of Japan study, through an analysis by the multifactor dimensionality reduction method, soy isoflavones, showed to exhibit its anti-prostate cancer, depending to differ between the genotypes of estrogen-related genes(3).
According to Dr. Kimura T., the incidence of prostate cancer in Asia is much lower than that in African Americans and European Caucasians and soy food consumption, more popular in Asian populations, is associated with a 25% to 30% reduced risk of prostate cancer, it may be as a result of genetic mutation of approximately 30 genetic polymorphisms in populations of countries in the West. (1).
Serum of isoflavones
In a case-control study within the Japan Public Health Center-based Prospective of a total of 14,203 men aged 40 to 69 years who had returned the baseline questionnaire and provided blood samples observed from 1990 to 2005, showed that plasma genistein level is associated inversely to the risk of prostate cancer(4).
Other in the study of four isoflavonoids in plasma of 14 Japanese and 14 Finnish men, also showed that the mean plasma of total individual isoflavonoid levels of Japanese is 7 to 110 times higher Japanese than in the Finnish men. Genistein, a tyrosine kinase inhibitor, occurred in the highest concentration(11).
In the experiment of Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet showed that the excretion of isoflavonoids correlated with soybean-product intake is associated to reduced mortality in breast and prostate cancer of Japanese women and men(12).
In view of the above, the Loma Linda University insisted that soy isoflavones should be tested against different populations of prostate cancer patients for its efficacy(6). Other suggested that the lower incidence of prostate cancer in Japanese men may be a result of traditional Japanese diet with a lot of soy foods and fishes(8) and promotes the production of Soy-derived food products and the metabolization of the isoflavones to enhance equol production to those of nonproducers of Asian and European/North American populations(13).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) East meets West: ethnic differences in prostate cancer epidemiology between East Asians and Caucasians by Kimura T.(PubMed)
(2) Hereditary prostate cancer and other genetic predispositions to prostate cancer by Cussenot O1, Valeri A, Berthon P, Fournier G, Mangin P.(PubMed)
(3) Polymorphisms in estrogen related genes may modify the protective effect of isoflavones against prostate cancer risk in Japanese men by Sonoda T1, Suzuki H, Mori M, Tsukamoto T, Yokomizo A, Naito S, Fujimoto K, Hirao Y, Miyanaga N, Akaza H.(PubMed)
(4) Plasma isoflavones and subsequent risk of prostate cancer in a nested case-control study: the Japan Public Health Center by Kurahashi N1, Iwasaki M, Inoue M, Sasazuki S, Tsugane S.(PubMed)
(5) Soy product and isoflavone consumption in relation to prostate cancerin Japanese men by Kurahashi N1, Iwasaki M, Sasazuki S, Otani T, Inoue M, Tsugane S; Japan Public Health Center-Based Prospective Study Group.(PubMed)
(6) An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels by Messina M1, Kucuk O, Lampe JW.(PubMed)
(7) Prostate cancer in native Japanese and Japanese-American men: effects of dietary differences on prostatic tissue by Marks LS1, Kojima M, Demarzo A, Heber D, Bostwick DG, Qian J, Dorey FJ, Veltri RW, Mohler JL, Partin AW.(PubMed)
(8) A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet by Sonoda T1, Nagata Y, Mori M, Miyanaga N, Takashima N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Fujioka T, Akaza H.(PubMed)
(9) Nagata Y1, Sonoda T, Mori M, Miyanaga N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Akaza H.(PubMed)
(10) Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study by Kolonel LN1, Hankin JH, Whittemore AS, Wu AH, Gallagher RP, Wilkens LR, John EM, Howe GR, Dreon DM, West DW, Paffenbarger RS Jr.(PubMed)
(11) Plasma concentrations of phyto-oestrogens in Japanese men by Adlercreutz H1, Markkanen H, Watanabe S.(PubMed) (12) Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet by Adlercreutz H1, Honjo H, Higashi A, Fotsis T, Hämäläinen E, Hasegawa T, Okada H.(PubMed)
(13) Prostate cancer chemoprevention by soy isoflavones: role of intestinal bacteria as the "second human genome" by Akaza H.(PubMed)
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein
I. Soy in Eastern population
A. The Japanese population
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years of healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b).
A3. Soy and Prostate cancer in Japanese Men
Prostate cancer is defined as a condition in which the cells of the prostate has become cancerous, causing abnormal cell growth with the possibility of spreading to the distant parts of the body. Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.
The widespread of prostate cancer, once considered a disease of aging male, now have become major concerns of governments and scientific community in South East Asian with a tendency to affect even younger age population. Suggestions emerged of over-consuming bad fats at any time in history accompanied by an unhealthy diet and lifestyle may be the possible causes of the disease, linking to the economic prosperity over 2 decades.
In fact, the incidence of prostate cancer in Asia is still lower if compared to their Western counterparts.
The Research Center for Cancer Prevention and Screening, National Cancer Center. suggested that isoflavones and soy food are associated with a dose-dependent decrease in the reduced risk of localized cancer, in a population-based prospective study in 43,509 Japanese men ages 45 to 74 years with participants responded to a validated questionnaire, which included 147 food items. During follow-up from 1995 through 2004, 307 men were newly diagnosed with prostate cancer, of which 74 cases were advanced, 220 cases were organ localized, and 13 cases were of an undetermined stage(5).
Environment, Diet, intestinal microbiota and Geography
The testing of North American Japanese and Japanese in Japan showed the environment factor may be involved in the development of prostate cancer regardless of genetic similarity(7). The incidence of the disease increased vary both from country to country and ethnic group, with the highest incidence reported for Afro-Americans and the lowest for Asian men(2).
The study of the associations between nutritional and other lifestyle factors and the prevalence of prostate cancer in a case-control study of Japanese men showed that soy isoflavone significantly decreased the risk of prostate cancer regardless of the intake of other nutrients such as PUFA, (n-6) fatty acids or magnesium from other food sources(9).
Others suggested that legumes (not limited to soy products) and certain categories of vegetables may protect against prostate cancer(10).
DR. Akaza H. said "not having equol converting bacteria in the intestine (non-equol producers) can be a risk factor for prostate cancer and that one direction for future research will be to examine the possibility of improving the intestinal environment to enable equol production"(13).
Genes differentiation
1n gene differentiation, estrogen-related genes may be the culprits for the development of prostate cancer. In one hundred and eighty cases and 177 controls selected from three geographic areas of Japan study, through an analysis by the multifactor dimensionality reduction method, soy isoflavones, showed to exhibit its anti-prostate cancer, depending to differ between the genotypes of estrogen-related genes(3).
According to Dr. Kimura T., the incidence of prostate cancer in Asia is much lower than that in African Americans and European Caucasians and soy food consumption, more popular in Asian populations, is associated with a 25% to 30% reduced risk of prostate cancer, it may be as a result of genetic mutation of approximately 30 genetic polymorphisms in populations of countries in the West. (1).
Serum of isoflavones
In a case-control study within the Japan Public Health Center-based Prospective of a total of 14,203 men aged 40 to 69 years who had returned the baseline questionnaire and provided blood samples observed from 1990 to 2005, showed that plasma genistein level is associated inversely to the risk of prostate cancer(4).
Other in the study of four isoflavonoids in plasma of 14 Japanese and 14 Finnish men, also showed that the mean plasma of total individual isoflavonoid levels of Japanese is 7 to 110 times higher Japanese than in the Finnish men. Genistein, a tyrosine kinase inhibitor, occurred in the highest concentration(11).
In the experiment of Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet showed that the excretion of isoflavonoids correlated with soybean-product intake is associated to reduced mortality in breast and prostate cancer of Japanese women and men(12).
In view of the above, the Loma Linda University insisted that soy isoflavones should be tested against different populations of prostate cancer patients for its efficacy(6). Other suggested that the lower incidence of prostate cancer in Japanese men may be a result of traditional Japanese diet with a lot of soy foods and fishes(8) and promotes the production of Soy-derived food products and the metabolization of the isoflavones to enhance equol production to those of nonproducers of Asian and European/North American populations(13).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) East meets West: ethnic differences in prostate cancer epidemiology between East Asians and Caucasians by Kimura T.(PubMed)
(2) Hereditary prostate cancer and other genetic predispositions to prostate cancer by Cussenot O1, Valeri A, Berthon P, Fournier G, Mangin P.(PubMed)
(3) Polymorphisms in estrogen related genes may modify the protective effect of isoflavones against prostate cancer risk in Japanese men by Sonoda T1, Suzuki H, Mori M, Tsukamoto T, Yokomizo A, Naito S, Fujimoto K, Hirao Y, Miyanaga N, Akaza H.(PubMed)
(4) Plasma isoflavones and subsequent risk of prostate cancer in a nested case-control study: the Japan Public Health Center by Kurahashi N1, Iwasaki M, Inoue M, Sasazuki S, Tsugane S.(PubMed)
(5) Soy product and isoflavone consumption in relation to prostate cancerin Japanese men by Kurahashi N1, Iwasaki M, Sasazuki S, Otani T, Inoue M, Tsugane S; Japan Public Health Center-Based Prospective Study Group.(PubMed)
(6) An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels by Messina M1, Kucuk O, Lampe JW.(PubMed)
(7) Prostate cancer in native Japanese and Japanese-American men: effects of dietary differences on prostatic tissue by Marks LS1, Kojima M, Demarzo A, Heber D, Bostwick DG, Qian J, Dorey FJ, Veltri RW, Mohler JL, Partin AW.(PubMed)
(8) A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet by Sonoda T1, Nagata Y, Mori M, Miyanaga N, Takashima N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Fujioka T, Akaza H.(PubMed)
(9) Nagata Y1, Sonoda T, Mori M, Miyanaga N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Akaza H.(PubMed)
(10) Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study by Kolonel LN1, Hankin JH, Whittemore AS, Wu AH, Gallagher RP, Wilkens LR, John EM, Howe GR, Dreon DM, West DW, Paffenbarger RS Jr.(PubMed)
(11) Plasma concentrations of phyto-oestrogens in Japanese men by Adlercreutz H1, Markkanen H, Watanabe S.(PubMed) (12) Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet by Adlercreutz H1, Honjo H, Higashi A, Fotsis T, Hämäläinen E, Hasegawa T, Okada H.(PubMed)
(13) Prostate cancer chemoprevention by soy isoflavones: role of intestinal bacteria as the "second human genome" by Akaza H.(PubMed)
Saturday, January 18, 2020
Bromelain, Stops Colon Cancer Developing in Vitro and Vivo
Colon cancer is a medical condition caused by irregular cell growth in the colon tissues.
The colon formed part of the large intestine is a part of the digestive system with function to reabsorb fluids and eliminate waste products from the body.
Most cases of colon cancer start in the cells on the surface of the inner lining tissue, before colonizing the deeper tissues.
Colon cancer is one of the slowest growth of tumors. The onset of cancer may sometimes take 20 years before the cancer symptoms are developed.
Most cases of colon cancer in the early stage are asymptomatic due to the very small size of cancer. However, at the advanced stage, colon cancer cells can travel a distance away to infect other healthy tissues and organs.
According to the statistics, in the US, approximately 1 million people are living with colon cancer. Every year, approximately 100,000 new cases of colon cancer are diagnosed.
Overall, the lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men, compared to 1 in 24 (4.15%) for women.
Older age, African-American race, people with family and personal history and inflammatory bowel disease and physical inactivity are some prevalent factors found in patients with the disease.
However, some researchers in the concern that colon cancer in the younger adult group suggested that the promotion of a high-fat diet over the past few decades may contribute to the increased risk of colon cancer in the US.
Dr. David Liska, MD, a colorectal surgeon at the Cleveland Clinic. wrote, "“The rise in colorectal rates in younger adults has been parallel to the rise in the obesity epidemic, so it’s reasonable to think that that’s a factor”.
And, “Many of the risk factors for obesity are also risk factors for colon cancer, including a high-fat diet that’s high in red meat and low in vegetables, as well as being sedentary. But I’m seeing a lot of younger patients who are at a normal weight and have a healthy lifestyle, so there have to be other reasons”.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
In the urgency to find a natural ingredient for the treatment of colon cancer, researchers examined the possible antiproliferative/pro-apoptotic effects of bromelain (from the pineapple stem Ananas comosus L., family Bromeliaceae) in a human colorectal carcinoma cell line and its potential chemopreventive effect in a murine model of colon cancer.
On human colon adenocarcinoma (Caco-2) cells, according to the tested assays, administration of bromelain inhibited protein expression associated with cell proliferation, anti-apoptosis, and reduction of reactive oxygen species production.
Furthermore, in vivo, bromelain exerts similar effects on colon carcinogenesis through its antiproliferative and proapoptotic activity and enhanced chemopreventive actions.
In other words, bromelain protected the colonic cell viability by preventing the risk of developing aberrant crypt foci, polyps, and tumors induced by azoxymethane.
Dr. Romano B, the lead scientist said, "Bromelain-containing foods and/or bromelain itself may represent good candidates for colorectal cancer chemoprevention".
In order to reveal more information about the bromelain property on colon cancer, researchers in the cancer team at Wonkwang University examined the bromelain activity in Kras mutant human colorectal carcinoma cell lines and a mouse model harboring a Kras mutation.
In the Kras mutant colorectal carcinoma cell lines, administration of 50 μg/mL bromelain reduced the cell growth and proliferation correlated to the inhibition of enzyme ACSL-4 involved in the promotion of cancer cell growth, invasion, and hormonal resistance and exhibited the microRNAs (miRNAs) that regulate the gene expression of ACSL-4.
Compared to the Kras wild-type colorectal cancer cells, bromelain effectively exerts cytotoxic effects in Kras mutant colorectal cancer cells.
In other words, bromelain demonstrated a significant effect in reduced colon cancer cell growth and anti-apoptosis by blocking the gene expression associated with such action by regulating its microRNAs.
Based on the findings, Researchers said, "Differential expression of ACSL-4 is responsible for the differential action of bromelain in regulating ferroptotic cell death".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects by Romano B1, Fasolino I, Pagano E, Capasso R, Pace S, De Rosa G, Milic N, Orlando P, Izzo AA, Borrelli F. (PubMed)
(2) Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis by Park S1, Oh J1, Kim M1, Jin EJ. (PubMed)
(3) This cancer is on the rise in young adults — and doctors don’t know why. (Yahoo Lifestyle)
The colon formed part of the large intestine is a part of the digestive system with function to reabsorb fluids and eliminate waste products from the body.
Most cases of colon cancer start in the cells on the surface of the inner lining tissue, before colonizing the deeper tissues.
Colon cancer is one of the slowest growth of tumors. The onset of cancer may sometimes take 20 years before the cancer symptoms are developed.
Most cases of colon cancer in the early stage are asymptomatic due to the very small size of cancer. However, at the advanced stage, colon cancer cells can travel a distance away to infect other healthy tissues and organs.
According to the statistics, in the US, approximately 1 million people are living with colon cancer. Every year, approximately 100,000 new cases of colon cancer are diagnosed.
Overall, the lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men, compared to 1 in 24 (4.15%) for women.
Older age, African-American race, people with family and personal history and inflammatory bowel disease and physical inactivity are some prevalent factors found in patients with the disease.
However, some researchers in the concern that colon cancer in the younger adult group suggested that the promotion of a high-fat diet over the past few decades may contribute to the increased risk of colon cancer in the US.
Dr. David Liska, MD, a colorectal surgeon at the Cleveland Clinic. wrote, "“The rise in colorectal rates in younger adults has been parallel to the rise in the obesity epidemic, so it’s reasonable to think that that’s a factor”.
And, “Many of the risk factors for obesity are also risk factors for colon cancer, including a high-fat diet that’s high in red meat and low in vegetables, as well as being sedentary. But I’m seeing a lot of younger patients who are at a normal weight and have a healthy lifestyle, so there have to be other reasons”.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
In the urgency to find a natural ingredient for the treatment of colon cancer, researchers examined the possible antiproliferative/pro-apoptotic effects of bromelain (from the pineapple stem Ananas comosus L., family Bromeliaceae) in a human colorectal carcinoma cell line and its potential chemopreventive effect in a murine model of colon cancer.
On human colon adenocarcinoma (Caco-2) cells, according to the tested assays, administration of bromelain inhibited protein expression associated with cell proliferation, anti-apoptosis, and reduction of reactive oxygen species production.
Furthermore, in vivo, bromelain exerts similar effects on colon carcinogenesis through its antiproliferative and proapoptotic activity and enhanced chemopreventive actions.
In other words, bromelain protected the colonic cell viability by preventing the risk of developing aberrant crypt foci, polyps, and tumors induced by azoxymethane.
Dr. Romano B, the lead scientist said, "Bromelain-containing foods and/or bromelain itself may represent good candidates for colorectal cancer chemoprevention".
In order to reveal more information about the bromelain property on colon cancer, researchers in the cancer team at Wonkwang University examined the bromelain activity in Kras mutant human colorectal carcinoma cell lines and a mouse model harboring a Kras mutation.
In the Kras mutant colorectal carcinoma cell lines, administration of 50 μg/mL bromelain reduced the cell growth and proliferation correlated to the inhibition of enzyme ACSL-4 involved in the promotion of cancer cell growth, invasion, and hormonal resistance and exhibited the microRNAs (miRNAs) that regulate the gene expression of ACSL-4.
Compared to the Kras wild-type colorectal cancer cells, bromelain effectively exerts cytotoxic effects in Kras mutant colorectal cancer cells.
In other words, bromelain demonstrated a significant effect in reduced colon cancer cell growth and anti-apoptosis by blocking the gene expression associated with such action by regulating its microRNAs.
Based on the findings, Researchers said, "Differential expression of ACSL-4 is responsible for the differential action of bromelain in regulating ferroptotic cell death".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects by Romano B1, Fasolino I, Pagano E, Capasso R, Pace S, De Rosa G, Milic N, Orlando P, Izzo AA, Borrelli F. (PubMed)
(2) Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis by Park S1, Oh J1, Kim M1, Jin EJ. (PubMed)
(3) This cancer is on the rise in young adults — and doctors don’t know why. (Yahoo Lifestyle)
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