Acute inflammation is a natural response of the immune system to protect the human body against harmful stimuli and pathogens.
Acute information is the first phase of injection. At this phase, after sensing the body injury by the central nervous system, the immune first line of defense stimulates the production of blood platelets to the cover the site of damage and pro-inflammatory to kill off pathogens that try to enter the body through the wound or damaged tissue.
Acute inflammation usually receded after a few days or weeks depending on the size and damage. However, if all pathogens were not eradicated after 3 to 8 weeks, the immune system will compromise, leading to chronic low-grade inflammation, a leading cause of chronic illness.
The most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.
Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of acute inflammation, researchers examined the effect of bromelain, a mixture of proteases derived from pineapple stem on inflammatory diseases, including murine inflammatory bowel disease.
According to the tested assays,* In vitro, bromelain modulated the immune activity by removing a number of cell surface molecules that are vital to leukocyte trafficking.
* Bromelain inhibited neutrophil migration to IL-8 and decreased acute responses to inflammatory stimuli in the initiation of the production of pro-inflammatory cytokines.
* In vivo, bromelain treatment generated a 50-85% reduction in neutrophil migration in 3 different murine models of leukocyte migration into the inflamed peritoneal cavity through its anti-inflammatory properties.
In other words, through its anti-inflammatory activity, bromelain inhibited the primary long-term effect on the abrogation of firm adhesion of leukocytes to blood vessels at the site of inflammation in the induction of inflammation.
Additionally, in an ovalbumin (OVA)-induced murine model of acute allergic airway disease (AAD) with female C57BL/6J mice sensitized with intraperitoneal (i.p.) OVA/alum and then challenged with OVA aerosols for 3 days, administration of 200 mg/kg bromelain twice daily for four consecutive days, exerted a significant anti-inflammatory activity against the overexpression of pro-inflammatory cytokines caused by the injection of ovalbumin (OVA).
Interestingly, bromelain also inhibited allergic inflammation by modulating the immune response against ovalbumin (OVA).
Based on the findings, researchers wrote, " these studies demonstrate that bromelain can effectively decrease neutrophil migration to sites of acute inflammation".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of acute inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain treatment decreases neutrophil migration to sites of inflammation by Fitzhugh DJ1, Shan S, Dewhirst MW, Hale LP. (PubMed)
(2) Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma by Secor ER1, Carson WF, Singh A, Pensa M, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
Monday, January 27, 2020
Herbal Artichoke Promotes Healthy Levels of Triglycerides
On seeking natural therapy with no side effects, scientists may have a whole herb for the prevention and treatment of overexpression of triglycerides, according to studies.
Triglycerides are body fat found in humans derived from glycerol and saturated, monounsaturated, and polyunsaturated fatty acid.
The triglycerides are stored in your fat cells to energy in the future when the body needs.
Unlike cholesterol produced by the liver and absorbed through diet to build cell walls, produce steroid hormone and vitamin D and aid digestive, the primary of triglycerides function is to store as unused calories and provide your body with energy.
In the health perspective, the levels of triglycerides can affect your health and risk of cardiovascular disease.
1. Normal, if your level is less than 150 milligrams per deciliter (mg/dL), or less than 1.7 millimoles per liter (mmol/L)
2. Borderline high if your level is between 150 and 199 mg/dL (1.8 and 2.2 mmol/L)
3. High, if your level is between 200 and 499 mg/dL (2.3 and 5.6 mmol)
4. Very high, if your level is above 500 mg/dL (above 5.7 mmol/L)
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of obesity investigated the artichoke extract anti overexpression of triglycerides by reviewing the medical literature online.
From the databases of PubMed-Medline, Scopus, Web of Science and Google Scholar databases up to March 28, 2017, RCTs satisfied the standard criteria and guidelines were selected to the investigation of the impact of artichoke extracts on plasma lipid levels.
According to the Meta-analysis of data from 9 trials including 702 subjects artichoke extract showed significant activity against the overexpression of plasma concentrations, including lowering the triglycerides by -9.2 mg/dL.
The injection of artichoke extract according to the selected studies did not exert any impact on the levels of high-density lipoprotein, compared to the strong effect on lowering the levels of low-density lipoprotein.
These results suggested that artichoke supplement reduced plasma lipid levels through inhibiting the levels of both total and LDL-C, and triglycerides.
Furthermore, in order to reveal more details of the artichoke effect on triglycerides, researchers examined fecal excretion of neutral bile acids and sterols in subjects after the artichoke leaf extract (ALE) intake.
The animal model study included 64 Golden Syrian hamsters (8 weeks old) fed randomly either a control diet or a similar diet containing ALE (4.5 g/kg diet) for 6 weeks.
According to the observation up to day 21, ALE injection showed no significant changes in plasma lipid levels, including non-HDL cholesterol triglycerides or fecal neutral sterols.
However, after day 42, ALE exerted a clinical significance in lowing the levels of triglycerides by 22% in males and 29% in female hamsters, compared to control.
The findings strongly suggested that ALE processes anti triglycerides accumulation by a mechanism involving the greater excretion of fecal bile acids and neutral sterols after feeding for 42 days.
According to the accumulated information, it is safe to say that artichoke may be considered a functional remedy for the treatment of elevated non-HDL cholesterol triglycerides with no side effects, pending to the validation of larger sample size and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(2) Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis by Sahebkar A1, Pirro M2, Banach M3,4, Mikhailidis DP5, Atkin SL6, Cicero AFG. (PubMed)
(1) Artichoke extract lowered plasma cholesterol and increased fecal bile acids in Golden Syrian hamsters by Qiang Z1, Lee SO, Ye Z, Wu X, Hendrich S. (PubMed)
Triglycerides are body fat found in humans derived from glycerol and saturated, monounsaturated, and polyunsaturated fatty acid.
The triglycerides are stored in your fat cells to energy in the future when the body needs.
Unlike cholesterol produced by the liver and absorbed through diet to build cell walls, produce steroid hormone and vitamin D and aid digestive, the primary of triglycerides function is to store as unused calories and provide your body with energy.
In the health perspective, the levels of triglycerides can affect your health and risk of cardiovascular disease.
1. Normal, if your level is less than 150 milligrams per deciliter (mg/dL), or less than 1.7 millimoles per liter (mmol/L)
2. Borderline high if your level is between 150 and 199 mg/dL (1.8 and 2.2 mmol/L)
3. High, if your level is between 200 and 499 mg/dL (2.3 and 5.6 mmol)
4. Very high, if your level is above 500 mg/dL (above 5.7 mmol/L)
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of obesity investigated the artichoke extract anti overexpression of triglycerides by reviewing the medical literature online.
From the databases of PubMed-Medline, Scopus, Web of Science and Google Scholar databases up to March 28, 2017, RCTs satisfied the standard criteria and guidelines were selected to the investigation of the impact of artichoke extracts on plasma lipid levels.
According to the Meta-analysis of data from 9 trials including 702 subjects artichoke extract showed significant activity against the overexpression of plasma concentrations, including lowering the triglycerides by -9.2 mg/dL.
The injection of artichoke extract according to the selected studies did not exert any impact on the levels of high-density lipoprotein, compared to the strong effect on lowering the levels of low-density lipoprotein.
These results suggested that artichoke supplement reduced plasma lipid levels through inhibiting the levels of both total and LDL-C, and triglycerides.
Furthermore, in order to reveal more details of the artichoke effect on triglycerides, researchers examined fecal excretion of neutral bile acids and sterols in subjects after the artichoke leaf extract (ALE) intake.
The animal model study included 64 Golden Syrian hamsters (8 weeks old) fed randomly either a control diet or a similar diet containing ALE (4.5 g/kg diet) for 6 weeks.
According to the observation up to day 21, ALE injection showed no significant changes in plasma lipid levels, including non-HDL cholesterol triglycerides or fecal neutral sterols.
However, after day 42, ALE exerted a clinical significance in lowing the levels of triglycerides by 22% in males and 29% in female hamsters, compared to control.
The findings strongly suggested that ALE processes anti triglycerides accumulation by a mechanism involving the greater excretion of fecal bile acids and neutral sterols after feeding for 42 days.
According to the accumulated information, it is safe to say that artichoke may be considered a functional remedy for the treatment of elevated non-HDL cholesterol triglycerides with no side effects, pending to the validation of larger sample size and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(2) Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis by Sahebkar A1, Pirro M2, Banach M3,4, Mikhailidis DP5, Atkin SL6, Cicero AFG. (PubMed)
(1) Artichoke extract lowered plasma cholesterol and increased fecal bile acids in Golden Syrian hamsters by Qiang Z1, Lee SO, Ye Z, Wu X, Hendrich S. (PubMed)
Sunday, January 26, 2020
The Effects of Calendula (Calendula officinalis) on Cancers
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe. It has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Ingredients
Besides major chemical constituents of triterpenoids, flavonoids, coumarins, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Calendula (Calendula officinalis) and Cancers
The study of Calendula against the Angiogenesis for the growth, invasion, and metastasis of most solid tumors, indicated the positive effect through its antiangiogenic activity via exhibited selectivity against the endothelial cells proliferation(1). Its extract, according to Universidad de Granada, also showed to exhibit cytotoxic tumor cell activity and induced lymphocyte activation in vivo against tumor growth of Ando-2 melanoma cells and prolonged the survival day of the mice, through cell cycle arrest in G0/G1 phase and Caspase-3-induced apoptosis(2).On lung metastasis by B16F-10 melanoma cells in C57BL/6 mice, Calendula officinalis flower extract showed to reduce the lung tumor nodules by 74% with 43.3% increase in life span, probably through the inhibition of key enzymes involved in processes of metastasis(3).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Screening the antiangiogenic activity of medicinal plants grown and sold in Jordan by Zihlif M1, Afifi F, Muhtaseb R, Al-Khatib S, Abaza I, Naffa R.(PubMed)
(2) A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation by Jiménez-Medina E1, Garcia-Lora A, Paco L, Algarra I, Collado A, Garrido F.(PubMed)
(3) Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers by Preethi KC1, Siveen KS, Kuttan R, Kuttan G.(PubMed)
Ingredients
Besides major chemical constituents of triterpenoids, flavonoids, coumarins, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Calendula (Calendula officinalis) and Cancers
The study of Calendula against the Angiogenesis for the growth, invasion, and metastasis of most solid tumors, indicated the positive effect through its antiangiogenic activity via exhibited selectivity against the endothelial cells proliferation(1). Its extract, according to Universidad de Granada, also showed to exhibit cytotoxic tumor cell activity and induced lymphocyte activation in vivo against tumor growth of Ando-2 melanoma cells and prolonged the survival day of the mice, through cell cycle arrest in G0/G1 phase and Caspase-3-induced apoptosis(2).On lung metastasis by B16F-10 melanoma cells in C57BL/6 mice, Calendula officinalis flower extract showed to reduce the lung tumor nodules by 74% with 43.3% increase in life span, probably through the inhibition of key enzymes involved in processes of metastasis(3).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Screening the antiangiogenic activity of medicinal plants grown and sold in Jordan by Zihlif M1, Afifi F, Muhtaseb R, Al-Khatib S, Abaza I, Naffa R.(PubMed)
(2) A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation by Jiménez-Medina E1, Garcia-Lora A, Paco L, Algarra I, Collado A, Garrido F.(PubMed)
(3) Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers by Preethi KC1, Siveen KS, Kuttan R, Kuttan G.(PubMed)
Herbal Artichoke, Protects Your Upper Digestive Tract Against Functional Dyspepsia (FD)
Functional dyspepsia (FD) is a chronic condition characterized by burning sensation caused by uncoordinated and ineffectual emptying of the upper digestive tract with no measurable structural abnormalities.
Functional dyspepsia (FD) are subdivided into two types: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS).
According to statistics, approximately 20-45% of Canadians have such condition, but only a low percentage of patients seek help from physicians. and functional dyspepsia accounts for 62.5% of dyspepsia in a population of black African patients, compared to other races.
The exact causes of functional dyspepsia are unidentified. Some researchers suggested that excessive acid secretion, inflammation, food allergies, unhealthy lifestyle choice and long term use of medications may have strong implications in the onset of the syndrome.
Pain, digestive discomforts such as fullness and bloating, excessive burping, nausea, and sometimes vomiting GERD, a sour taste in the mouth are the most common symptoms of functional dyspepsia.
If you experience some of the aforementioned symptoms, please make sure you check with your doctor to rule out the possibility.
Some researchers suggested that unhealthy dietary habits are one of the major risk factors associated with the onset of FD in the world.
Dr. Ji-Hao Xu, the lead scientist in the assessment of dietary habit in the risk of FD, wrote, "Unhealthy dietary habits were more prevalent in the FD group than in the control groups (75.86% versus 37.50%; p<0.001). FD was found to be associated with irregular mealtime, dining out, fatty food, sweet food, and coffee (p<0.05). The impact of each dietary factor varied with FD subtypes".
And, "Certain types of dietary habits were positively correlated with the prevalence of FD. FD subtypes showed relatively different associations with dietary factors".
The finding strongly suggested by following a healthy diet pattern, FD may be preventable.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
On the finding a natural therapeutics for the treatment of functional dyspepsia (FD), researchers compared the efficacy of ginger and artichoke supplementation (SG) versus placebo in the treatment of FD.
The prospective multicentre, double-blind, randomized, placebo-controlled, parallel-group comparison of the supplement and placebo over a period of 4 weeks included 126 FD patients given 2 capsules/day (before lunch and dinner (supplementation/placebo: 65/61).
After 14 days, supplement treatment showed a significant amelioration of FD, compared to placebo.
SG treatment group also showed a significant reduction of nausea, epigastric fullness, epigastric pain, and bloating compared to placebo.
Dr.Giacosa A, the lead scientist wrote, "The association between ginger and artichoke leaf extracts appears safe and efficacious in the treatment of FD and could represent a promising treatment for this disease".
In order to reveal more information about artichoke anti-FD property, researchers assessed the efficacy of artichoke leaf extract (ALE) in the treatment of patients with functional dyspepsia (FD).
The double-blind, randomized controlled trial (RCT) included 247 patients with functional dyspepsia treated with either a commercial ALE preparation (2 x 320 mg plant extract t.d.s.) or a placebo.
ALE improved the overall symptom significantly over the 6 weeks compared to the placebo
Similarly, patients treated with ALE also showed significantly greater improvement in the global quality-of-life scores (NDI) compared to the placebo.
Dr. Holtmann G, the lead scientist after taking into account co and confounders wrote in the final report, "he ALE preparation tested was significantly better than the placebo in alleviating symptoms and improving the disease-specific quality of life in patients with functional dyspepsia".
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of functional dyspepsia (FD), pending to the confirmation of a larger sample and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial by Giacosa A1, Guido D2, Grassi M2, Riva A3, Morazzoni P3, Bombardelli E3, Perna S4
(2) Efficacy of artichoke leaf extract in the treatment of patients with functionaldyspepsia: a six-week placebo-controlled, double-blind, multicentre trial by Holtmann G1, Adam B, Haag S, Collet W, Grünewald E, Windeck T. (PubMed)
(3) Certain Dietary Habits Contribute to the Functional Dyspepsia in South China Rural Area by Xu JH1, Lai Y1, Zhuang LP2, Huang CZ1, Li CQ1, Chen QK1, Yu T1. (PubMed)
Functional dyspepsia (FD) are subdivided into two types: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS).
According to statistics, approximately 20-45% of Canadians have such condition, but only a low percentage of patients seek help from physicians. and functional dyspepsia accounts for 62.5% of dyspepsia in a population of black African patients, compared to other races.
The exact causes of functional dyspepsia are unidentified. Some researchers suggested that excessive acid secretion, inflammation, food allergies, unhealthy lifestyle choice and long term use of medications may have strong implications in the onset of the syndrome.
Pain, digestive discomforts such as fullness and bloating, excessive burping, nausea, and sometimes vomiting GERD, a sour taste in the mouth are the most common symptoms of functional dyspepsia.
If you experience some of the aforementioned symptoms, please make sure you check with your doctor to rule out the possibility.
Some researchers suggested that unhealthy dietary habits are one of the major risk factors associated with the onset of FD in the world.
Dr. Ji-Hao Xu, the lead scientist in the assessment of dietary habit in the risk of FD, wrote, "Unhealthy dietary habits were more prevalent in the FD group than in the control groups (75.86% versus 37.50%; p<0.001). FD was found to be associated with irregular mealtime, dining out, fatty food, sweet food, and coffee (p<0.05). The impact of each dietary factor varied with FD subtypes".
And, "Certain types of dietary habits were positively correlated with the prevalence of FD. FD subtypes showed relatively different associations with dietary factors".
The finding strongly suggested by following a healthy diet pattern, FD may be preventable.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
On the finding a natural therapeutics for the treatment of functional dyspepsia (FD), researchers compared the efficacy of ginger and artichoke supplementation (SG) versus placebo in the treatment of FD.
The prospective multicentre, double-blind, randomized, placebo-controlled, parallel-group comparison of the supplement and placebo over a period of 4 weeks included 126 FD patients given 2 capsules/day (before lunch and dinner (supplementation/placebo: 65/61).
After 14 days, supplement treatment showed a significant amelioration of FD, compared to placebo.
SG treatment group also showed a significant reduction of nausea, epigastric fullness, epigastric pain, and bloating compared to placebo.
Dr.Giacosa A, the lead scientist wrote, "The association between ginger and artichoke leaf extracts appears safe and efficacious in the treatment of FD and could represent a promising treatment for this disease".
In order to reveal more information about artichoke anti-FD property, researchers assessed the efficacy of artichoke leaf extract (ALE) in the treatment of patients with functional dyspepsia (FD).
The double-blind, randomized controlled trial (RCT) included 247 patients with functional dyspepsia treated with either a commercial ALE preparation (2 x 320 mg plant extract t.d.s.) or a placebo.
ALE improved the overall symptom significantly over the 6 weeks compared to the placebo
Similarly, patients treated with ALE also showed significantly greater improvement in the global quality-of-life scores (NDI) compared to the placebo.
Dr. Holtmann G, the lead scientist after taking into account co and confounders wrote in the final report, "he ALE preparation tested was significantly better than the placebo in alleviating symptoms and improving the disease-specific quality of life in patients with functional dyspepsia".
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of functional dyspepsia (FD), pending to the confirmation of a larger sample and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial by Giacosa A1, Guido D2, Grassi M2, Riva A3, Morazzoni P3, Bombardelli E3, Perna S4
(2) Efficacy of artichoke leaf extract in the treatment of patients with functionaldyspepsia: a six-week placebo-controlled, double-blind, multicentre trial by Holtmann G1, Adam B, Haag S, Collet W, Grünewald E, Windeck T. (PubMed)
(3) Certain Dietary Habits Contribute to the Functional Dyspepsia in South China Rural Area by Xu JH1, Lai Y1, Zhuang LP2, Huang CZ1, Li CQ1, Chen QK1, Yu T1. (PubMed)
The Herbal Burdock Antitussive Effects
Burdock is plants in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. It has been used over a thousand of years in Chins and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
The antitussive effect is considered as a coughing suppression activity with the use as substance, including herb, medication
The ingredients
It contains carbonated water, sugar,, manloid colourings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemical compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid, etc.
The benefits
polysaccharides found in Burdock may be the potential agent to treat a pathological type of cough as its polysaccharides exhibited statistically significant cough-suppressing activity, which was noticeably higher than that of the non-narcotic drug used in clinical practice to treat coughing. Also A biologically active fructan from the roots of Arctium lappa L., var. Herkules is was found to be equally active as some non-narcotic, synthetic preparations used in clinical practice to treat coughing.
The Side effects
1. Overdose can be poisoning and may lead to symptoms of acute poisoning include phenothiazines, tricyclic antidepressants, and antihistamines.
2. It may cause dermatitis and allergic/inflammatory responses to certain people with contact as a result of lactones that the plant produces.
3. Do not use burdock if you are pregnant or breastfeeding.
4. Etc.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html
References
(1) The antitussive activity of polysaccharides from Althaea officinalis l., var. Robusta, Arctium lappa L., var. Herkules, and Prunus persica L., Batsch by Sutovska M, Nosalova G, Franova S, Kardosova A.(PubMed)
(2) A biologically active fructan from the roots of Arctium lappa L., var. Herkules. by Kardosová A, Ebringerová A, Alföldi J, Nosál'ová G, Franová S, Hríbalová V.(PubMed)
The antitussive effect is considered as a coughing suppression activity with the use as substance, including herb, medication
The ingredients
It contains carbonated water, sugar,, manloid colourings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemical compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid, etc.
The benefits
polysaccharides found in Burdock may be the potential agent to treat a pathological type of cough as its polysaccharides exhibited statistically significant cough-suppressing activity, which was noticeably higher than that of the non-narcotic drug used in clinical practice to treat coughing. Also A biologically active fructan from the roots of Arctium lappa L., var. Herkules is was found to be equally active as some non-narcotic, synthetic preparations used in clinical practice to treat coughing.
The Side effects
1. Overdose can be poisoning and may lead to symptoms of acute poisoning include phenothiazines, tricyclic antidepressants, and antihistamines.
2. It may cause dermatitis and allergic/inflammatory responses to certain people with contact as a result of lactones that the plant produces.
3. Do not use burdock if you are pregnant or breastfeeding.
4. Etc.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html
References
(1) The antitussive activity of polysaccharides from Althaea officinalis l., var. Robusta, Arctium lappa L., var. Herkules, and Prunus persica L., Batsch by Sutovska M, Nosalova G, Franova S, Kardosova A.(PubMed)
(2) A biologically active fructan from the roots of Arctium lappa L., var. Herkules. by Kardosová A, Ebringerová A, Alföldi J, Nosál'ová G, Franová S, Hríbalová V.(PubMed)
Saturday, January 25, 2020
Herbal Bilberry Normalizes the Blood Glucose in Diabetics
Hyperglycemia is a condition of abnormally high blood glucose associated with the elevated risk of heart disease, stroke, and diabetes.
In other words, overexpression of blood cholesterol is one the condition of metabolic syndrome cluster involved diabetic complications.
Long-term untreated and unmanaged hyperglycemia was found to induce kidney damage or kidney failure in diabetes.
Some researchers suggested that long-term untreated and unmanaged hyperglycemia was associated with severe damage to the blood vessels of the retina, potentially leading to blindness and wounds such as on the leg that can not be healed.
On the other hand, hypoglycemia is a condition caused by abnormally low levels of blood glucose. Most cases of acute hypoglycemia in healthy individuals is a result of hunger due to the miss of the meal.
In diabetes, the condition may be caused by overdoses of insulin injection or medications. In some cases, hypoglycemia may be caused by a diabetic person who doesn't eat as much food as usual after taking diabetes medication.
Symptoms of hypoglycemia may include dizziness, nausea, cold sweats, a fast heart rate, confusion, headache, irritability, coma, and possibly even death, depending on the levels of blood glucose.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Searching in a list of natural ingredients for the treatment of hyperglycemia, scientists investigated the bilberry's polyphenolic compounds on carbohydrate and lipid metabolism in Wistar rats with streptozotocin (STZ) and high-fructose diet (HFD)-induced diabetes.
In the comparison of the Vaccinium myrtillus L. (bilberry) leaf (VLE) and Phaseolus vulgaris L. seed coat (PCE) plant extracts effects on hypoglycemic properties, male Wistar rats with STZ and HFD-induced diabetes selected to the study were fed with or without VLE or PCE for 50 d.
According to the blood sample collected, the injection of VLE showed a significantly ameliorative effect on carbohydrate metabolism in diabetic rats.
Furthermore, the administration of VLE in diabetic animals normalized the HbA levels in 4 out of 8 treatment rats.
Moreover, the VLE treatment group also displayed a significant reduction in blood glucose levels by 50% compared with the control of diabetic rats.
Compared to the PLE treatment group, VLE and PLE groups showed an antioxidant effect on diene compounds in the blood serum of rats.
The findings suggested that VLE exerts potential anti hypoglycemia probably through enhancing the antioxidant enzymes produced by the host rats.
In order to find more information about bilberry antihyperglycemic activity and confirm the use of bilberry traditional medicine for the treatment of diabetes, researchers investigate the effects of bilberry against DM.
Selected animals in the study induced diabetes by the intraperitoneal injection of alloxan (120 mg kg(-1) body weight (BW))were treated by Bilberry powder (2 g d(-1)) or glibenclamide (positive control; 0.6 mg kg(-1) BW) for 4 weeks following alloxan injection.
Bilberry supplementation injection resulted in a significant reduction of glucose compared to diabetic control and glibenclamide.
Additionally, bilberry demonstrated strong activity against symptoms of diabetes by elevating the levels of insulin, reducing TC, LDL-C, VLDL-C and TG levels, and preventing the decline of HDL-C.
However, the levels of CRP in the expression of inflammation did not significantly change with either bilberry or glibenclamide.
Dr. the lead scientist said, "Dietary supplementation with bilberry fruits may protect against impaired glucose and lipid metabolism in DM".
Taken altogether, bilberry may be considered a functional food for the treatment of hyperglycemia and hyperglycemic complications of diabetes, pending to the further confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hypoglycemic and hypolipidemic effect of Vaccinium myrtillus L. leaf and Phaseolus vulgaris L. seed coat extracts in diabetic rats by Sidorova Y1, Shipelin V2, Mazo V1, Zorin S1, Petrov N1, Kochetkova A. (PubMed)
(2) Anti-hyperglycemic and anti-hyperlipidemic effects of Vaccinium myrtillus fruit in experimentally induced diabetes (antidiabetic effect of Vaccinium myrtillus fruit) by Asgary S1, RafieianKopaei M2, Sahebkar A3, Shamsi F1, Goli-malekabadi N. (PubMed)
In other words, overexpression of blood cholesterol is one the condition of metabolic syndrome cluster involved diabetic complications.
Long-term untreated and unmanaged hyperglycemia was found to induce kidney damage or kidney failure in diabetes.
Some researchers suggested that long-term untreated and unmanaged hyperglycemia was associated with severe damage to the blood vessels of the retina, potentially leading to blindness and wounds such as on the leg that can not be healed.
On the other hand, hypoglycemia is a condition caused by abnormally low levels of blood glucose. Most cases of acute hypoglycemia in healthy individuals is a result of hunger due to the miss of the meal.
In diabetes, the condition may be caused by overdoses of insulin injection or medications. In some cases, hypoglycemia may be caused by a diabetic person who doesn't eat as much food as usual after taking diabetes medication.
Symptoms of hypoglycemia may include dizziness, nausea, cold sweats, a fast heart rate, confusion, headache, irritability, coma, and possibly even death, depending on the levels of blood glucose.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Searching in a list of natural ingredients for the treatment of hyperglycemia, scientists investigated the bilberry's polyphenolic compounds on carbohydrate and lipid metabolism in Wistar rats with streptozotocin (STZ) and high-fructose diet (HFD)-induced diabetes.
In the comparison of the Vaccinium myrtillus L. (bilberry) leaf (VLE) and Phaseolus vulgaris L. seed coat (PCE) plant extracts effects on hypoglycemic properties, male Wistar rats with STZ and HFD-induced diabetes selected to the study were fed with or without VLE or PCE for 50 d.
According to the blood sample collected, the injection of VLE showed a significantly ameliorative effect on carbohydrate metabolism in diabetic rats.
Furthermore, the administration of VLE in diabetic animals normalized the HbA levels in 4 out of 8 treatment rats.
Moreover, the VLE treatment group also displayed a significant reduction in blood glucose levels by 50% compared with the control of diabetic rats.
Compared to the PLE treatment group, VLE and PLE groups showed an antioxidant effect on diene compounds in the blood serum of rats.
The findings suggested that VLE exerts potential anti hypoglycemia probably through enhancing the antioxidant enzymes produced by the host rats.
In order to find more information about bilberry antihyperglycemic activity and confirm the use of bilberry traditional medicine for the treatment of diabetes, researchers investigate the effects of bilberry against DM.
Selected animals in the study induced diabetes by the intraperitoneal injection of alloxan (120 mg kg(-1) body weight (BW))were treated by Bilberry powder (2 g d(-1)) or glibenclamide (positive control; 0.6 mg kg(-1) BW) for 4 weeks following alloxan injection.
Bilberry supplementation injection resulted in a significant reduction of glucose compared to diabetic control and glibenclamide.
Additionally, bilberry demonstrated strong activity against symptoms of diabetes by elevating the levels of insulin, reducing TC, LDL-C, VLDL-C and TG levels, and preventing the decline of HDL-C.
However, the levels of CRP in the expression of inflammation did not significantly change with either bilberry or glibenclamide.
Dr. the lead scientist said, "Dietary supplementation with bilberry fruits may protect against impaired glucose and lipid metabolism in DM".
Taken altogether, bilberry may be considered a functional food for the treatment of hyperglycemia and hyperglycemic complications of diabetes, pending to the further confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hypoglycemic and hypolipidemic effect of Vaccinium myrtillus L. leaf and Phaseolus vulgaris L. seed coat extracts in diabetic rats by Sidorova Y1, Shipelin V2, Mazo V1, Zorin S1, Petrov N1, Kochetkova A. (PubMed)
(2) Anti-hyperglycemic and anti-hyperlipidemic effects of Vaccinium myrtillus fruit in experimentally induced diabetes (antidiabetic effect of Vaccinium myrtillus fruit) by Asgary S1, RafieianKopaei M2, Sahebkar A3, Shamsi F1, Goli-malekabadi N. (PubMed)
Bromelain Protects the Cell DNA Against Genotoxicity
Genotoxicity is a process of destruction on a cell's genetic material (DNA, RNA), leading to gene mutation.
In other words, genotoxins are mutagens, the substances which have been found to induce cancer. The most common genotoxins are radiation and toxic chemicals.
Believe it or not, besides causing cancer, genotoxins are found to induce various types of genetic diseases, by the damage of the germ cell.
Some researchers suggested that the damage of DNA may be controlled if the genotoxins are identified through the use of anti antimutagens /anti-clastogens that suppress or inhibit the mutagenesis process.
The most common causes of genetic damage or alternation are reactive oxygen species (ROS), the unstable and genotoxic molecules that exist everywhere in the environment and inside the human body.
By regulating the levels of free radicals in the body through the increased antioxidant enzyme inside the host or from the dietary sources, oxidative stress induced by ROS may be controlled. Thereby, reducing the risk of gene damage.
Dr. Mohamed SAKS, the lead scientist wrote in the article published in the Global Journal of Pharmacy & Pharmaceutical Sciences, "There are mainly two mechanisms of anti-mutagenesis:
a. Desmutagenesis in which the factors on the mutagens are somehow inactivated,
b. Bio-antimutagenesis, in which the factors act on the process of mutagenesis or by repairing the damaged DNA that results in the decreased frequency of DNA mutation [15]. a number of cells have a DNA repair system by which they try to control the DNA mutations naturally".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential treatment cancer, researchers examined the genotoxic effect of
pineapple extract on oral cancer cell line by DNA fragmentation.
According to the DNA fragmentation assay, bromelain showed a significantly genotoxic activity by invading the cancer nucleus and causes damage to the nucleic acid.
In the examine 3 different doses of bromelain incubated with oral cancer cells, DNA fragmentation occurred in all three concentrations.
In other words, bromelain inhibited oral cancer cell progression through genotoxic properties.
Furthermore, bromelain also inhibited the expression of MUC1, a glycoprotein associated with tumor cells invasive, metastatic, and chemo-resistant properties in breast and pancreatic cancer cells.
Moreover, bromelain used a combination with either cisplatin and 5-FU also enhanced conventional medicine efficacy.
Additionally, in malignant peritoneal mesothelioma (MPM) expressed MUC1, the administration of bromelain also affected the viability of MPM cells adversely.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of cancer through its genotoxic activity, pending to the confirmation of the larger sample size and multicenter human study
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Genotoxicity analysis of pineapple extract on oral cancer cell line by DNA fragmentation by A.A. Mahtani, R. Gayathri, and V. Vishnu Priya. (Research Gate)
(2) Anticancer Property of Bromelain With Therapeutic Potential in Malignant Peritoneal Mesothelioma by Krishna Pillai, Javed Akhter, Terence C Chua & David Lawson Morris. (Taylor and Francis Online)
(3) Genotoxicity: Mechanisms, Testing Guidelines and Methods by Mohamed SAKS, Sabita Upreti, Rajendra SV* and Raman Dang. (the Global Journal of Pharmacy & Pharmaceutical Sciences)
In other words, genotoxins are mutagens, the substances which have been found to induce cancer. The most common genotoxins are radiation and toxic chemicals.
Believe it or not, besides causing cancer, genotoxins are found to induce various types of genetic diseases, by the damage of the germ cell.
Some researchers suggested that the damage of DNA may be controlled if the genotoxins are identified through the use of anti antimutagens /anti-clastogens that suppress or inhibit the mutagenesis process.
The most common causes of genetic damage or alternation are reactive oxygen species (ROS), the unstable and genotoxic molecules that exist everywhere in the environment and inside the human body.
By regulating the levels of free radicals in the body through the increased antioxidant enzyme inside the host or from the dietary sources, oxidative stress induced by ROS may be controlled. Thereby, reducing the risk of gene damage.
Dr. Mohamed SAKS, the lead scientist wrote in the article published in the Global Journal of Pharmacy & Pharmaceutical Sciences, "There are mainly two mechanisms of anti-mutagenesis:
a. Desmutagenesis in which the factors on the mutagens are somehow inactivated,
b. Bio-antimutagenesis, in which the factors act on the process of mutagenesis or by repairing the damaged DNA that results in the decreased frequency of DNA mutation [15]. a number of cells have a DNA repair system by which they try to control the DNA mutations naturally".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential treatment cancer, researchers examined the genotoxic effect of
pineapple extract on oral cancer cell line by DNA fragmentation.
According to the DNA fragmentation assay, bromelain showed a significantly genotoxic activity by invading the cancer nucleus and causes damage to the nucleic acid.
In the examine 3 different doses of bromelain incubated with oral cancer cells, DNA fragmentation occurred in all three concentrations.
In other words, bromelain inhibited oral cancer cell progression through genotoxic properties.
Furthermore, bromelain also inhibited the expression of MUC1, a glycoprotein associated with tumor cells invasive, metastatic, and chemo-resistant properties in breast and pancreatic cancer cells.
Moreover, bromelain used a combination with either cisplatin and 5-FU also enhanced conventional medicine efficacy.
Additionally, in malignant peritoneal mesothelioma (MPM) expressed MUC1, the administration of bromelain also affected the viability of MPM cells adversely.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of cancer through its genotoxic activity, pending to the confirmation of the larger sample size and multicenter human study
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Genotoxicity analysis of pineapple extract on oral cancer cell line by DNA fragmentation by A.A. Mahtani, R. Gayathri, and V. Vishnu Priya. (Research Gate)
(2) Anticancer Property of Bromelain With Therapeutic Potential in Malignant Peritoneal Mesothelioma by Krishna Pillai, Javed Akhter, Terence C Chua & David Lawson Morris. (Taylor and Francis Online)
(3) Genotoxicity: Mechanisms, Testing Guidelines and Methods by Mohamed SAKS, Sabita Upreti, Rajendra SV* and Raman Dang. (the Global Journal of Pharmacy & Pharmaceutical Sciences)
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