Rheumatism or rheumatic disorder is a group of medical conditions associated with chronic, often intermittent pain that affects the joints and/or connective tissue.
The most common symptoms of rheumatism are joint pain, loss of motion in a joint or joints and low-grade inflammation that causes swelling, redness, and warmth in a joint or affected area.
Most common types of rheumatism are
* Osteoarthritis (OA), a form of arthritis, is a condition of aging-induced wear and tears on a joint, affecting over 25 million people in the US.
* Rheumatoid arthritis (RA) is a chronic disorder associated with the inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. RA affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders.
* Gout mostly effected one joint is an acute and recurrent condition of arthritis caused by uric acid building up in the blood, inducing joint inflammation.
* Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
* Polymalagia arthritis is a condition of inflammatory rheumatic disease which causes pain, stiffness, and tenderness in large muscles, including muscle shoulders and pelvic girdle.
* Lupus is an autoimmune disease, caused by the immune system overreaction that attacks its tissues, causing inflammation, swelling, pain, and damage.
* Juvenile idiopathic arthritis (JIA) is the type of arthritis that occurs in children with symptoms of persistent joint swelling, pain, and stiffness
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of arthritis, researchers examined the effect of an oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) in the treatment of rheumatic diseases.
The retrospective cohort study with parallel groups was to compare the efficacy of enzyme combination to those of nonsteroidal anti-inflammatory drugs (NSAID).
According to the data of 3326 patients treated for rheumatic diseases in which 2139 patients were treated either only with OE or only with NSAID, between January 1993 and the end of March 1995 registered by 380 physicians, both treatments yielded similar results.
However, there was a 50% higher success rate in OE than for NSAID, compared to the initial and treatment situations.
OE also scored higher stratification according to propensity score.
Furthermore, treatment duration more than 30 days and joint diseases or fibromyalgias in age over 50 years, pre-treatment with antirheumatic or analgesic drugs showed significant negative effects in patients' response compared to those of OE.
Additionally, according to the aforementioned and other indicators associated with freedom from symptoms, OE exerted an expectation compared to NSAID treatment.
The results strongly support the use of the oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) for the treatment of rheumatic disease instead of NSAIDs
Dr. Wittenborg A, after taking other factors into account, wrote in the final report, "OE were well tolerated showing much less adverse events when compared with conventional doses of NSAID".
Taken altogether, bromelain combined with conventional medicine may be considered a remedy for the prevention and treatment of rheumatic disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review].[Article in German] by Heyll U1, Münnich U, Senger V. (PubMed)
(2) [Comparative epidemiological study in patients with rheumatic diseases illustrated in a example of a treatment with non-steroidal anti- inflammatory drugs versus an oral enzyme combination preparation].[Article in German] by Wittenborg A1, Bock PR, Hanisch J, Saller R, Schneider B. (PubMed)
(3) General Health by Kyle J. Norton
Thursday, January 30, 2020
Herbal Bilberry, A Natural Prevention and Treatment of Alzheimer's disease (AD) with No Side Effects
Alzheimer's disease (AD) is a neurodegenerative disease found mostly in the aging population characterized by impaired memory, thinking, and behavior. caused by the gradual loss or death of neurons. These symptoms are slowly getting worse over time and becoming severe enough to interfere with daily activity.
60 percent to 80 percent of dementia found in the US are involved in Alzheimer's disease (AD).
According to the statistics, the number of patients living with AD is growing fast, affecting over 5.5 million people age 65 and older. AD is a sith leading cause of death in the US. Most patients AD lives four to eight years after diagnosis. However, the years of survival rate is totally depending on other factors.
In contrast to general belief, getting old is a risk factor of AD but AD is not a disease of aging. Approximately 200,000 Americans under the age of 65 have younger-onset Alzheimer’s disease.
As of today, there is no cure for AD, the aim of treatment is to slow down the severity of the symptoms and delay the progression of the disease.
In other words, treatment is to improve the quality of life for both patients and their caregivers.
Besides aging, physically active, smoking, excessive alcohol drinking, medical conditions such as metabolic syndrome, stress are some of the prevalent risks of AD.
Some researchers in the investigation of the correlation between obesity and AD wrote, "There is ample scientific as well as empirical evidence that obesity and its metabolic and vascular comorbidities are related to AD and likely in the causative pathway".
And, "Obesity prevention and treatment could prove to be an efficacious and safe approach to preventing AD, a serious and daunting epidemic disease".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In searching a natural ingredient for the treatment of Alzheimer's disease with no side effects, researchers at the effects of different polyphenols on neuroprotection and APP processing under different stress conditions in transgenic AD mice (APdE9).
Selected mice induced free radical toxicity and apoptosis in human SH-SY5Y neuroblastoma cells overexpressing APP751.
APdE9 mice fed with anthocyanin-rich bilberry showed the decreased Amyloid Precursor Protein (APP)APP C-terminal fragment levels, the indication of reduced death of neurons in the cerebral cortex compared to APdE9 mice fed with the control diet.
Furthermore, soluble Aβ40 and Aβ42 levels, the plaque in the brain associated with increased risk for AD, mild cognitive impairment, and cognitive decline were significantly decreased in bilberry-fed mice, compared to blackcurrant-fed mice.
Moreover, the bilberry diet protected the spatial working memory of aged APdE9 mice, compared to mice on the control diet, thus reducing the risk of deficits.
The results clearly suggested bilberry diet protects the integrity and viability of the neuron in the brain against the risk of AD.
Dr. Vepsäläinen S, the lead scientist said, "These data suggest that anthocyanin-rich bilberry and blackcurrant diets favorably modulate APP processing and alleviate behavioral abnormalities in a mouse model of AD".
In order to reveal more information about bilberry anti AD activity, researchers examined the anthocyanoside extracts (Vaccinium myrtillus anthocyanoside (VMA)) obtained from bilberry on the aggregation and deposition of the amyloid beta (Aβ1-42) peptide in fibrillar form.
According to the tested assays, injection of VMA protected Neuro2a cells by inhibiting the formation of Aβ peptide fibrils and reducing the toxicity of these aggregates in vitro.
A diet containing 1% VMA was found to exhibit significant activity in the prevention of cognitive degeneration in AD tested mice.
Interestingly, VMA promoted the cognitive ability accompanied not by a reduction in an aggregate deposition in brains, rather an increase in insoluble deposits compared to control diet mice.
In other words, bilberry protected the brain neuro against the risk AD by diverting Aβ aggregation to insoluble deposits, an alternate, non-toxic form.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a functioning remedy for the prevention and treatment of AD, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in vitro and in vivo models of Alzheimer's disease by Yamakawa MY, Uchino K, Watanabe Y, Adachi T, Nakanishi M, Ichino H, Hongo K, Mizobata T, Kobayashi S, Nakashima K, Kawata, (PubMed)
(2) Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease by Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. (PubMed)
(3) Obesity as a risk factor for Alzheimer's disease: weighing the evidence by Alford S1, Patel D2,3, Perakakis N4, Mantzoros CS. (PubMed)
60 percent to 80 percent of dementia found in the US are involved in Alzheimer's disease (AD).
According to the statistics, the number of patients living with AD is growing fast, affecting over 5.5 million people age 65 and older. AD is a sith leading cause of death in the US. Most patients AD lives four to eight years after diagnosis. However, the years of survival rate is totally depending on other factors.
In contrast to general belief, getting old is a risk factor of AD but AD is not a disease of aging. Approximately 200,000 Americans under the age of 65 have younger-onset Alzheimer’s disease.
As of today, there is no cure for AD, the aim of treatment is to slow down the severity of the symptoms and delay the progression of the disease.
In other words, treatment is to improve the quality of life for both patients and their caregivers.
Besides aging, physically active, smoking, excessive alcohol drinking, medical conditions such as metabolic syndrome, stress are some of the prevalent risks of AD.
Some researchers in the investigation of the correlation between obesity and AD wrote, "There is ample scientific as well as empirical evidence that obesity and its metabolic and vascular comorbidities are related to AD and likely in the causative pathway".
And, "Obesity prevention and treatment could prove to be an efficacious and safe approach to preventing AD, a serious and daunting epidemic disease".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In searching a natural ingredient for the treatment of Alzheimer's disease with no side effects, researchers at the effects of different polyphenols on neuroprotection and APP processing under different stress conditions in transgenic AD mice (APdE9).
Selected mice induced free radical toxicity and apoptosis in human SH-SY5Y neuroblastoma cells overexpressing APP751.
APdE9 mice fed with anthocyanin-rich bilberry showed the decreased Amyloid Precursor Protein (APP)APP C-terminal fragment levels, the indication of reduced death of neurons in the cerebral cortex compared to APdE9 mice fed with the control diet.
Furthermore, soluble Aβ40 and Aβ42 levels, the plaque in the brain associated with increased risk for AD, mild cognitive impairment, and cognitive decline were significantly decreased in bilberry-fed mice, compared to blackcurrant-fed mice.
Moreover, the bilberry diet protected the spatial working memory of aged APdE9 mice, compared to mice on the control diet, thus reducing the risk of deficits.
The results clearly suggested bilberry diet protects the integrity and viability of the neuron in the brain against the risk of AD.
Dr. Vepsäläinen S, the lead scientist said, "These data suggest that anthocyanin-rich bilberry and blackcurrant diets favorably modulate APP processing and alleviate behavioral abnormalities in a mouse model of AD".
In order to reveal more information about bilberry anti AD activity, researchers examined the anthocyanoside extracts (Vaccinium myrtillus anthocyanoside (VMA)) obtained from bilberry on the aggregation and deposition of the amyloid beta (Aβ1-42) peptide in fibrillar form.
According to the tested assays, injection of VMA protected Neuro2a cells by inhibiting the formation of Aβ peptide fibrils and reducing the toxicity of these aggregates in vitro.
A diet containing 1% VMA was found to exhibit significant activity in the prevention of cognitive degeneration in AD tested mice.
Interestingly, VMA promoted the cognitive ability accompanied not by a reduction in an aggregate deposition in brains, rather an increase in insoluble deposits compared to control diet mice.
In other words, bilberry protected the brain neuro against the risk AD by diverting Aβ aggregation to insoluble deposits, an alternate, non-toxic form.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a functioning remedy for the prevention and treatment of AD, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in vitro and in vivo models of Alzheimer's disease by Yamakawa MY, Uchino K, Watanabe Y, Adachi T, Nakanishi M, Ichino H, Hongo K, Mizobata T, Kobayashi S, Nakashima K, Kawata, (PubMed)
(2) Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease by Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. (PubMed)
(3) Obesity as a risk factor for Alzheimer's disease: weighing the evidence by Alford S1, Patel D2,3, Perakakis N4, Mantzoros CS. (PubMed)
Herbal Ashwagandha Kills Osteosarcoma Cells in Vitro
Osteosarcoma is a type of bone cancer found mostly in teenagers and people over age 60.
Most cases of osteosarcoma are associated with genetic syndromes. In other words, Osteosarcoma is associated with a genetic preposition inherited from the parent.
According to the statistic from the American Cancer Society, each year, approximately 800 to 900 new cases of osteosarcoma are diagnosed in the United States with half of these are in children and teens.
The exact causes of osteosarcoma are unidentified. However, epidemiologically, besides gene expression, an unhealthy lifestyle such as body weight, physical activity, diet, and tobacco, gender, age, height, ethnicity and exposure to bone radiation are also some prevalent factors found in patients with the disease.
Dr. Jeff W. Martin, the lead scientist at the Hospital for Sick Children and Queen's University wrote, "The etiology of this often aggressive cancer is currently unknown because complicated structural and numeric genomic rearrangements in cancer cells preclude the understanding of tumor development.",
And, " few consistent genetic changes that may indicate effective molecular therapeutic targets have been reported. However, high-resolution techniques continue to improve knowledge of distinct areas of the genome that are more commonly associated with osteosarcomas".
The overall 5-year survival rate for children and teens with osteosarcoma is 70%. If cancer has spread to the lung, the 5-year survival rate is only 40% compared to localized cancer between 60% to 80%.
Conventionally, most cases of osteosarcoma are o treated with a combination of surgery, chemotherapy and radiation therapy.
In patients with high-grade tumors, before surgery, neo-adjuvant therapy may be necessary to shrink the tumor.
Ashwagandha (WA)also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of cancers, researchers examined evaluated the safety and pharmacokinetics of WA.
In Vitro, Withaferin-A (WF-A), a major bioactive compound found in WA exhibited strong antiproliferative activity against several osteosarcoma cell lines, with IC50 ranging from 0.32 to 7.6 μM. The lowest IC50 (0.32 μM).
At the lowest IC50 (0.32 μM), WF-A showed a significant effect on the inhibition of U2OS cell line, compared to other cell lines.
Most importantly, WF-A induced ROS cytotoxicity against the tested cell lines in a dose-dependent manner and activation of cell death protein in osteosarcoma cells.
In the safety analysis, if the phase I dose-escalation study, using the classical 3 + 3 design (C33D) is comprised of 72, 108, 144 and 216 mg of WA administered in two to four divided doses per day in selected patients, including 3 patients enrolled in each cohort with the last patient who was observed for at least 30 days for any dose-limiting toxicity before progressing to a higher cohort, researchers found that the formulation was generally well tolerated with no grade 3 or grade 4 adverse events were observed, however, the formulation at the tested doses caused 11 adverse events of grade 1 or grade 2 severity.
Mose common symptoms are fatigue, fever, edema, and diarrhea. No levels of WA circulation. were found in the blood plasma. The low oral bioavailability of WA was also observed during the experimental period.
Based on the findings, researchers wrote, "The formulation was well tolerated. However, WA appears to have low oral bioavailability. Further studies with improved formulations are warranted".
Taken altogether, Ashwagandha is safe and may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of osteosarcomas, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Safety and Pharmacokinetics of Withaferin-A in advanced stage high grade Osteosarcoma: A phase I trial by Pires N1, Gota V1, Gulia A2, Hingorani L3, Agarwal M2, Puri A. (PubMed)
(2) Withaferin-A Induces Apoptosis in Osteosarcoma U2OS Cell Line via Generation of ROS and Disruption of Mitochondrial Membrane Potential by Zhang HL1,2, Zhang H. (PubMed)
(3) The Genetics of Osteosarcoma by Jeff W. Martin,1 Jeremy A. Squire,2 and Maria Zielenska. (Hindawi)
Most cases of osteosarcoma are associated with genetic syndromes. In other words, Osteosarcoma is associated with a genetic preposition inherited from the parent.
According to the statistic from the American Cancer Society, each year, approximately 800 to 900 new cases of osteosarcoma are diagnosed in the United States with half of these are in children and teens.
The exact causes of osteosarcoma are unidentified. However, epidemiologically, besides gene expression, an unhealthy lifestyle such as body weight, physical activity, diet, and tobacco, gender, age, height, ethnicity and exposure to bone radiation are also some prevalent factors found in patients with the disease.
Dr. Jeff W. Martin, the lead scientist at the Hospital for Sick Children and Queen's University wrote, "The etiology of this often aggressive cancer is currently unknown because complicated structural and numeric genomic rearrangements in cancer cells preclude the understanding of tumor development.",
And, " few consistent genetic changes that may indicate effective molecular therapeutic targets have been reported. However, high-resolution techniques continue to improve knowledge of distinct areas of the genome that are more commonly associated with osteosarcomas".
The overall 5-year survival rate for children and teens with osteosarcoma is 70%. If cancer has spread to the lung, the 5-year survival rate is only 40% compared to localized cancer between 60% to 80%.
Conventionally, most cases of osteosarcoma are o treated with a combination of surgery, chemotherapy and radiation therapy.
In patients with high-grade tumors, before surgery, neo-adjuvant therapy may be necessary to shrink the tumor.
Ashwagandha (WA)also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of cancers, researchers examined evaluated the safety and pharmacokinetics of WA.
In Vitro, Withaferin-A (WF-A), a major bioactive compound found in WA exhibited strong antiproliferative activity against several osteosarcoma cell lines, with IC50 ranging from 0.32 to 7.6 μM. The lowest IC50 (0.32 μM).
At the lowest IC50 (0.32 μM), WF-A showed a significant effect on the inhibition of U2OS cell line, compared to other cell lines.
Most importantly, WF-A induced ROS cytotoxicity against the tested cell lines in a dose-dependent manner and activation of cell death protein in osteosarcoma cells.
In the safety analysis, if the phase I dose-escalation study, using the classical 3 + 3 design (C33D) is comprised of 72, 108, 144 and 216 mg of WA administered in two to four divided doses per day in selected patients, including 3 patients enrolled in each cohort with the last patient who was observed for at least 30 days for any dose-limiting toxicity before progressing to a higher cohort, researchers found that the formulation was generally well tolerated with no grade 3 or grade 4 adverse events were observed, however, the formulation at the tested doses caused 11 adverse events of grade 1 or grade 2 severity.
Mose common symptoms are fatigue, fever, edema, and diarrhea. No levels of WA circulation. were found in the blood plasma. The low oral bioavailability of WA was also observed during the experimental period.
Based on the findings, researchers wrote, "The formulation was well tolerated. However, WA appears to have low oral bioavailability. Further studies with improved formulations are warranted".
Taken altogether, Ashwagandha is safe and may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of osteosarcomas, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Safety and Pharmacokinetics of Withaferin-A in advanced stage high grade Osteosarcoma: A phase I trial by Pires N1, Gota V1, Gulia A2, Hingorani L3, Agarwal M2, Puri A. (PubMed)
(2) Withaferin-A Induces Apoptosis in Osteosarcoma U2OS Cell Line via Generation of ROS and Disruption of Mitochondrial Membrane Potential by Zhang HL1,2, Zhang H. (PubMed)
(3) The Genetics of Osteosarcoma by Jeff W. Martin,1 Jeremy A. Squire,2 and Maria Zielenska. (Hindawi)
Wednesday, January 29, 2020
Herbal Ashwagandha Protects the Kidneys Against Acute Toxicity
Kidneys, a pair of the bean-shaped organ in the human body only filter out blood but also balances the body fluids by eliminating them and remove them through urinary secretion.
Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.
Kidney disease is a medical condition that causes the reduced function of the kidney due to damage.
In other words, the progression of kidney damage may affect the function of the kidney to filter blood
against toxins.
Most patients with chronic kidney disease also found to have conditions of diabetes or high blood pressure.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness
In severe cases, patients may also have symptoms of shortness of breath, confusion, and irregular heartbeat.
The worse cases of kidney damage can lead to renal failure, a condition that induces wastes and toxins accumulated in the blood. In this stage, dialysis and kidney transplant are the only options.
Kidney damage can be classified into 4 different stages
* Stage 1 with normal or high GFR (GFR > 90 mL/min). In this stage of kidney patients are asymptomatic.
* Stage 2 Mild CKD (GFR = 60-89 mL/min), Patients in this stage also experience no symptoms.
*Stage 3A Moderate CKD (GFR = 45-59 mL/min) and 3B moderate CKD (GFR = 30-44 mL/min.
Most patients are asymptomatic. However, some patients may experience symptoms of mild swelling in the hands and feet, back pain and urinating more or less than normal.
* Stage 4 CKD (GFR = 15-30 mL/min). Most patients in this stage experience more severe symptoms of swelling in the hands and feet, back pain and urinating more or less than normal, accompanied by other health problem associated with weakened kidney function
* Stage 5 EndStage CKD (GFR <15 mL/min). Patients at this advanced stage are very close to renal failure or renal failure. Symptoms are getting worse.
Where eGFR is short for estimated glomerular filtration rate.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of kidney disease, researchers examined the effects of Withania somnifera on rats-induced nephrotoxicity.
The study included selected rat oral administrated by The root extract of three different doses of W. somnifera (viz., 250, 500, and 750 mg/kg) for 14 days before GEN treatment and thereafter concurrently with GEN (100 mg/kg) for 8 days.
Based on the tested differentiation, GEN treatment group showed significant nephrotoxicity associated with kidney injury by an increase in kidney weight, urea, creatinine, urinary protein, and glucose, and a significant reduction in body weights and potassium by enhancing the overexpression of free radicals.
Compared to somnifera doses of W. somnifera at 250 and 750 mg/kg, the administration of 500 mg/kg showed the strongest effect in reversing the aforementioned changed observed by the microscopically antioxidant evidence.
In other words, W. somnifera protected the kidney against acute toxicity in a dose-dependent manner.
However, there were no significant changes in the levels of sodium in the experimental animals compared to control.
Based on the findings, researchers said, "nephroprotective effect of Withania somnifera, which could be by enhancing antioxidant activity with natural antioxidants and scavenging the free radicals".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of periodontitis, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of Withania somnifera root powder on lipid peroxidation and antioxidant status in gentamicin-induced nephrotoxic rats by Jeyanthi T1, Subramanian P. (PubMed)
(2) Nephroprotective effect of Withania somnifera: a dose-dependent study by Jeyanthi T1, Subramanian P. (PubMed)
Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.
Kidney disease is a medical condition that causes the reduced function of the kidney due to damage.
In other words, the progression of kidney damage may affect the function of the kidney to filter blood
against toxins.
Most patients with chronic kidney disease also found to have conditions of diabetes or high blood pressure.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness
In severe cases, patients may also have symptoms of shortness of breath, confusion, and irregular heartbeat.
The worse cases of kidney damage can lead to renal failure, a condition that induces wastes and toxins accumulated in the blood. In this stage, dialysis and kidney transplant are the only options.
Kidney damage can be classified into 4 different stages
* Stage 1 with normal or high GFR (GFR > 90 mL/min). In this stage of kidney patients are asymptomatic.
* Stage 2 Mild CKD (GFR = 60-89 mL/min), Patients in this stage also experience no symptoms.
*Stage 3A Moderate CKD (GFR = 45-59 mL/min) and 3B moderate CKD (GFR = 30-44 mL/min.
Most patients are asymptomatic. However, some patients may experience symptoms of mild swelling in the hands and feet, back pain and urinating more or less than normal.
* Stage 4 CKD (GFR = 15-30 mL/min). Most patients in this stage experience more severe symptoms of swelling in the hands and feet, back pain and urinating more or less than normal, accompanied by other health problem associated with weakened kidney function
* Stage 5 EndStage CKD (GFR <15 mL/min). Patients at this advanced stage are very close to renal failure or renal failure. Symptoms are getting worse.
Where eGFR is short for estimated glomerular filtration rate.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of kidney disease, researchers examined the effects of Withania somnifera on rats-induced nephrotoxicity.
The study included selected rat oral administrated by The root extract of three different doses of W. somnifera (viz., 250, 500, and 750 mg/kg) for 14 days before GEN treatment and thereafter concurrently with GEN (100 mg/kg) for 8 days.
Based on the tested differentiation, GEN treatment group showed significant nephrotoxicity associated with kidney injury by an increase in kidney weight, urea, creatinine, urinary protein, and glucose, and a significant reduction in body weights and potassium by enhancing the overexpression of free radicals.
Compared to somnifera doses of W. somnifera at 250 and 750 mg/kg, the administration of 500 mg/kg showed the strongest effect in reversing the aforementioned changed observed by the microscopically antioxidant evidence.
In other words, W. somnifera protected the kidney against acute toxicity in a dose-dependent manner.
However, there were no significant changes in the levels of sodium in the experimental animals compared to control.
Based on the findings, researchers said, "nephroprotective effect of Withania somnifera, which could be by enhancing antioxidant activity with natural antioxidants and scavenging the free radicals".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of periodontitis, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of Withania somnifera root powder on lipid peroxidation and antioxidant status in gentamicin-induced nephrotoxic rats by Jeyanthi T1, Subramanian P. (PubMed)
(2) Nephroprotective effect of Withania somnifera: a dose-dependent study by Jeyanthi T1, Subramanian P. (PubMed)
Cat's Claw, the Best Whole Herb medicine for Reduced Symptoms and Treatment of Inflammatory arthritis
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Arthritis is one common musculoskeletal disorders (MSDs) inflammatory diseases, affecting one or more joints with symptoms of joint pain and stiffness.
Cat's claw may be used for treatment in reduced symptoms of arthritis patients through interfering the regulated phosphohydrolytic activity in the prevention of arthritis induction causes to tissue damage.
In the review of 16 clinical studies (11 randomized, placebo-controlled clinical trials, three crossover trials, one case-controlled study, and one open-label study), the Bethesda North Hospital Pharmacy, suggested, cat's claw may be used as a nonsteroidal anti-inflammatory drug or steroid usage in some studies.
In a total of 50 patients with RA, undergoing sulfasalazine or hydroxychloroquine treatment enrolled in a randomized 52 week, 2 phase study, 24 weeks of treatment with the UT extract exhibited a reduction of the number of painful joints compared to placebo (by 53.2% vs 24.1%; p = 0.044),
In fact, " Cat's claw also exhibited antioxidant effect against inflammation through reduction of pro-inflammatory mediators and effectors" Dr. Hardin SR said.
Dr. Sandoval M.. the lead author at the Albany Medical College, suggested. oral pretreatment for UT protected against inflammatory disorders, through the interaction of the pro-inflammatory expression with its antioxidant properties.
Although Cat's claw may be effective for reduced symptoms and treatment of inflammatory arthritis. The use of the whole herb quantity should be taken with care as toxicity is found in some cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Effect of Uncaria tomentosa extract on purinergic enzyme activities in lymphocytes of rats submitted to experimental adjuvant arthritis model by Castilhos LG1, Rezer JF2,3, Ruchel JB4,5, Thorstenberg ML6,7, Jaques JA8,9, Schlemmer JB10,11, Doleski PH12, Rossato MF13, da Silva MA14, Casalli EA15,16, da Cruz RC17, Ferreira J18, Athayde ML19, Gonçalves JF20,21, Leal DB22,2(PubMed)
(2) Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis by Rosenbaum CC1, O'Mathúna DP, Chavez M, Shields K.(PubMed)
(3) Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis by Mur E1, Hartig F, Eibl G, Schirmer M.(PubMed)
(4) Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis by Hardin SR1(PubMed)
(5) Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content by Sandoval M1, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ.(PubMed)
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Arthritis is one common musculoskeletal disorders (MSDs) inflammatory diseases, affecting one or more joints with symptoms of joint pain and stiffness.
Cat's claw may be used for treatment in reduced symptoms of arthritis patients through interfering the regulated phosphohydrolytic activity in the prevention of arthritis induction causes to tissue damage.
In the review of 16 clinical studies (11 randomized, placebo-controlled clinical trials, three crossover trials, one case-controlled study, and one open-label study), the Bethesda North Hospital Pharmacy, suggested, cat's claw may be used as a nonsteroidal anti-inflammatory drug or steroid usage in some studies.
In a total of 50 patients with RA, undergoing sulfasalazine or hydroxychloroquine treatment enrolled in a randomized 52 week, 2 phase study, 24 weeks of treatment with the UT extract exhibited a reduction of the number of painful joints compared to placebo (by 53.2% vs 24.1%; p = 0.044),
In fact, " Cat's claw also exhibited antioxidant effect against inflammation through reduction of pro-inflammatory mediators and effectors" Dr. Hardin SR said.
Dr. Sandoval M.. the lead author at the Albany Medical College, suggested. oral pretreatment for UT protected against inflammatory disorders, through the interaction of the pro-inflammatory expression with its antioxidant properties.
Although Cat's claw may be effective for reduced symptoms and treatment of inflammatory arthritis. The use of the whole herb quantity should be taken with care as toxicity is found in some cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Effect of Uncaria tomentosa extract on purinergic enzyme activities in lymphocytes of rats submitted to experimental adjuvant arthritis model by Castilhos LG1, Rezer JF2,3, Ruchel JB4,5, Thorstenberg ML6,7, Jaques JA8,9, Schlemmer JB10,11, Doleski PH12, Rossato MF13, da Silva MA14, Casalli EA15,16, da Cruz RC17, Ferreira J18, Athayde ML19, Gonçalves JF20,21, Leal DB22,2(PubMed)
(2) Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis by Rosenbaum CC1, O'Mathúna DP, Chavez M, Shields K.(PubMed)
(3) Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis by Mur E1, Hartig F, Eibl G, Schirmer M.(PubMed)
(4) Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis by Hardin SR1(PubMed)
(5) Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content by Sandoval M1, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ.(PubMed)
Herbal Burdock, the Potent Hepatoprotective Remedy
Herbal Burdock may process a liver protective activity against the onset of liver disease, according to the studies.
The liver is a large organ that processes the function in detoxifying various metabolites, synthesizing proteins, and producing bile for digestion.
Liver diseases are medical conditions of liver damage, leading to reduced function of the liver.
There are many risk factors that cause liver diseases, including genetic preposition, viral infections and long-term use of medication and excessive alcohol drinking.
Liver diseases in most case progress slowly. However, over time the damage can lead to cirrhosis, the main cause of liver failure, and a life-threatening condition.
According to the statistic, in the US, cirrhosis and other chronic liver diseases are common disease-related causes of death. Approximately 31,000 people in the U.S. die each year from cirrhosis.
Sadly, approximately, 3.5 to 4.6 million people in the U.S. are chronically infected with the hepatitis C virus.
If you are experiencing symptoms of jaundice, persistent abdominal pain, and swelling, dark urine color, pale stool color, or bloody or tar-colored stool, please check with your doctor to rule out the possibility of liver diseases.
The most common cause of liver disease in the third world is hepatitis viral infection, it may be a result of drinking contaminated water and food and lack of clean water.
However, in the Western world, obesity is the major cause of nonalcoholic liver disease. Dr. Sandra Milić, the lead scientist in the concern of the non-alcoholic liver disease in obese wrote,
"Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Presentation of the disease ranges from simple steatosis to non-alcoholic steatohepatitis (NASH). NAFLD is a hepatic manifestation of metabolic syndrome that includes central abdominal obesity along with other components. Up to 80% of patients with NAFLD are obese, defined as a body mass index (BMI) > 30 kg/m2."
These results clearly suggested if you are obese you are at 80% most likely to be infected by non- alcoholic liver disease.
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. The herbal has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
The herbal plant contains carbonated water, sugar,, manloid colorings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.
On finding a natural remedy for the treatment of liver diseases, researchers at the Taipei Medical University examined the Arctium lappa Linne (burdock)hepatoprotective effects.
The experiment included a group of rats (n = 10) fed a liquid ethanol diet (4 g of absolute ethanol/ 80 ml of liquid basal diet) for 28 days and another group (n = 10) received a single intraperitoneal injection of 0.5 ml/kg carbon tetrachloride (CCl(4)) in order to potentiate the liver damage on the 21st day (1 day before the beginning of A. lappa treatment).
Control group rats were given a liquid basal diet which did not contain absolute ethanol.
Before administrating of herbal Burdock, ethanol group and the groups receiving ethanol supplemented with CCl(4). showed significant damage to the liver.
However, treated rat groups with a dose of 300 mg/kg A. lappa administered orally 3 times per day in both the 1-day and 7-day displayed significantly improved various pathological and biochemical parameters which were worsened by ethanol plus CCl(4)-induced liver damage, including decreased levels of serum triglyceride and lipid peroxidation and serum transaminase levels.
Where the elevated levels of serum transaminase is an indication of liver damage.
The finding clearly suggested that hepatotoxicity induced by ethanol and potentiated by CCl(4) could be alleviated with 1 and 7 days of A. lappa treatment.
Dr. Lin SC, the lead author wrote in the final report, "The hepatoprotective mechanism of A. lappa could be attributed, at least in part, to its antioxidative activity, which decreases the oxidative stress of hepatocytes, or to another unknown protective mechanism(s)".
Moreover, in male ICR mice injected with carbon tetrachloride (CCl4, 32 microl/kg, i.p.) or acetaminophen (600 mg/kg, i.p.) to induce liver damage, researchers found that injection of A. lappa significantly suppresses the serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) elevations induced by CCl4 or acetaminophen in a dose-dependent manner.
Furthermore, A. lappa also alleviated the severity of liver damage based on histopathological observations.
Where the elevation of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) is the indication of liver damage.
The efficacy of A. lappa in the in-depth analysis assays was found to attribute to the antioxidant activity in inhibiting the expression of free radicals induced by CCl4 or acetaminophen
A. lappa also was found to decrease the oxidative stress marker, malondialdehyde (MDA) content in CCl4 or acetaminophen-intoxicated mice.
Dr. Lin SC the lead scientist after taking into account co and confounders said, "A. lappa could protect the liver cells from CCl4 or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4 or acetaminophen".
Taken altogether, herbal Burdock may be considered a natural remedy for the prevention and treatment of liver disease without inducing any side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride by Lin SC, Lin CH, Lin CC, Lin YH, Chen CF, Chen IC, Wang LY.(PubMed)
(2) Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage by Lin SC, Chung TC, Lin CC, Ueng TH, Lin YH, Lin SY, Wang LY.(PubMed)
(3) Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations by Sandra Milić, Davorka Lulić, and Davor Štimac. (PubMed)
The liver is a large organ that processes the function in detoxifying various metabolites, synthesizing proteins, and producing bile for digestion.
Liver diseases are medical conditions of liver damage, leading to reduced function of the liver.
There are many risk factors that cause liver diseases, including genetic preposition, viral infections and long-term use of medication and excessive alcohol drinking.
Liver diseases in most case progress slowly. However, over time the damage can lead to cirrhosis, the main cause of liver failure, and a life-threatening condition.
According to the statistic, in the US, cirrhosis and other chronic liver diseases are common disease-related causes of death. Approximately 31,000 people in the U.S. die each year from cirrhosis.
Sadly, approximately, 3.5 to 4.6 million people in the U.S. are chronically infected with the hepatitis C virus.
If you are experiencing symptoms of jaundice, persistent abdominal pain, and swelling, dark urine color, pale stool color, or bloody or tar-colored stool, please check with your doctor to rule out the possibility of liver diseases.
The most common cause of liver disease in the third world is hepatitis viral infection, it may be a result of drinking contaminated water and food and lack of clean water.
However, in the Western world, obesity is the major cause of nonalcoholic liver disease. Dr. Sandra Milić, the lead scientist in the concern of the non-alcoholic liver disease in obese wrote,
"Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Presentation of the disease ranges from simple steatosis to non-alcoholic steatohepatitis (NASH). NAFLD is a hepatic manifestation of metabolic syndrome that includes central abdominal obesity along with other components. Up to 80% of patients with NAFLD are obese, defined as a body mass index (BMI) > 30 kg/m2."
These results clearly suggested if you are obese you are at 80% most likely to be infected by non- alcoholic liver disease.
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. The herbal has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
The herbal plant contains carbonated water, sugar,, manloid colorings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.
On finding a natural remedy for the treatment of liver diseases, researchers at the Taipei Medical University examined the Arctium lappa Linne (burdock)hepatoprotective effects.
The experiment included a group of rats (n = 10) fed a liquid ethanol diet (4 g of absolute ethanol/ 80 ml of liquid basal diet) for 28 days and another group (n = 10) received a single intraperitoneal injection of 0.5 ml/kg carbon tetrachloride (CCl(4)) in order to potentiate the liver damage on the 21st day (1 day before the beginning of A. lappa treatment).
Control group rats were given a liquid basal diet which did not contain absolute ethanol.
Before administrating of herbal Burdock, ethanol group and the groups receiving ethanol supplemented with CCl(4). showed significant damage to the liver.
However, treated rat groups with a dose of 300 mg/kg A. lappa administered orally 3 times per day in both the 1-day and 7-day displayed significantly improved various pathological and biochemical parameters which were worsened by ethanol plus CCl(4)-induced liver damage, including decreased levels of serum triglyceride and lipid peroxidation and serum transaminase levels.
Where the elevated levels of serum transaminase is an indication of liver damage.
The finding clearly suggested that hepatotoxicity induced by ethanol and potentiated by CCl(4) could be alleviated with 1 and 7 days of A. lappa treatment.
Dr. Lin SC, the lead author wrote in the final report, "The hepatoprotective mechanism of A. lappa could be attributed, at least in part, to its antioxidative activity, which decreases the oxidative stress of hepatocytes, or to another unknown protective mechanism(s)".
Moreover, in male ICR mice injected with carbon tetrachloride (CCl4, 32 microl/kg, i.p.) or acetaminophen (600 mg/kg, i.p.) to induce liver damage, researchers found that injection of A. lappa significantly suppresses the serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) elevations induced by CCl4 or acetaminophen in a dose-dependent manner.
Furthermore, A. lappa also alleviated the severity of liver damage based on histopathological observations.
Where the elevation of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) is the indication of liver damage.
The efficacy of A. lappa in the in-depth analysis assays was found to attribute to the antioxidant activity in inhibiting the expression of free radicals induced by CCl4 or acetaminophen
A. lappa also was found to decrease the oxidative stress marker, malondialdehyde (MDA) content in CCl4 or acetaminophen-intoxicated mice.
Dr. Lin SC the lead scientist after taking into account co and confounders said, "A. lappa could protect the liver cells from CCl4 or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4 or acetaminophen".
Taken altogether, herbal Burdock may be considered a natural remedy for the prevention and treatment of liver disease without inducing any side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride by Lin SC, Lin CH, Lin CC, Lin YH, Chen CF, Chen IC, Wang LY.(PubMed)
(2) Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage by Lin SC, Chung TC, Lin CC, Ueng TH, Lin YH, Lin SY, Wang LY.(PubMed)
(3) Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations by Sandra Milić, Davorka Lulić, and Davor Štimac. (PubMed)
Tuesday, January 28, 2020
Eggplant, the Free Radical Scavengers Functional Food
Scientists may have found a whole vegetable which processes the function in balancing the ratio of free radicals and antioxidants, some studies suggested.
Free radicals are unstable molecules with an unpaired electron in the outer ring. In order for them to become stable, free radicals always seek other atoms or molecules to bond to leading to domino's effect that cannot stop until they are either pair or inhibited by antioxidants
The continuation of this domino's effects is known to begin a process called oxidative stress. A prolonged period of overexpression of free radicals can cause oxidative stress, a major cause of some chronic diseases, including diabetes.
Truly, free radicals and oxidants play a dual role as both toxic and beneficial compounds. On the benefit side, according to Wanjek wrote in 2006, "The body's ability to turn air and food into chemical energy depends on a chain reaction of free radicals. Free radicals are also a crucial part of the immune system, floating through the veins and attacking foreign invaders".
Free radicals can promote toxicity to cancer cells, leading to antiproliferative and apoptotic effects without harming the nearby healthy cell if administration with dietary antioxidants or stimulated the production of antioxidants enzymes in the host through healthy food sources.
On the other hand, overexpression of free radical can be very harmful, Dr. Lien Ai Pham-Huy, the lead author in the study "Free Radicals, Antioxidants in Disease and Health" said, "When an overload of free radicals cannot gradually be destroyed, their accumulation in the body generates a phenomenon called oxidative stress. This process plays a major part in the development of chronic and degenerative illnesses such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular and neurodegenerative diseases".
"The human body has several mechanisms to counteract oxidative stress by producing antioxidants, which are either naturally produced in situ, or externally supplied through foods and/or supplements".
These analyses suggested that a healthy diet and lifestyle play a critical role in reducing the risk of imbalance of the ratio of free radicals and antioxidants by increasing the expression of antioxidants and decreasing the risk of overload of free radicals.
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India. The plant has been cultivated in southern and eastern Asia since prehistory.
It is famous for its deep purple and the best eggplant can be found from August through October when it is in season.
The vegetable chemical compounds include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.
In the reaffirming of the effects of eggplant rich source of polyphenol compounds endowed with antioxidant properties, researchers launched an evaluation to compare the antioxidant activity of the extract polyphenols from eggplant entire fruit, pulp, or skin, both fresh and dry and conventional extraction and microwave-assisted extraction (MAE).
In the time exposure 15, 30, 60, and 90 min) and solvent water 100% or ethanol/water, researchers found that 50% dry peeled skin treated with 50% aqueous ethanol, exerted a good antioxidant activity expressed by its capacity to scavenge superoxide anion and to inhibit lipid peroxidation compared to another eggplant extract.
Furthermore, in the evaluation of the antioxidant and radical scavenging activities of Solanum anguivi fruit (SAG)(Eggplant) and its possible effect on mitochondrial permeability transition pore as well as mitochondrial membrane potential (ΔΨm) isolated from rat liver, researchers showed that
* SAG exhibited potent and concentration-dependent free radical-scavenging activity (IC50/DPPH=275.03±7.8 μg/mL).
* Reductive and iron chelation abilities also increase with an increase in SAG concentration.
* SAG also inhibited peroxidation of cerebral and hepatic lipids subjected to iron oxidative assault.
The effect of eggplant in reducing the expression of free radical was attributed to the presence of major bioactive compounds, including gallic acid [(17.54±0.04) mg/g], chlorogenic acid (21.90±0.02 mg/g), caffeic acid (16.64±0.01 mg/g), rutin [(14.71±0.03) mg/g] and quercetin [(7.39±0.05) mg/g].
Dr. Elekofehinti OO, the lead scientist said, "SAG extract is a potential source of natural antioxidants that may be used not only in the pharmaceutical and food industry but also in the treatment of diseases associated with oxidative stress".
Taken all together, there is no doubt that eggplant processes a powerful antioxidants activity in the prevention of overexpression of free radical in the initiation of oxidative stress and combined with a primary theory for the treatment of oxidative stress-related diseases, depending on the confirmation of further data collection from the large example size and multi-center studies in human.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant activity and phenolic content of microwave-assisted Solanum melongena extracts by Salerno L, Modica MN, Pittalà V, Romeo G, Siracusa MA, Di Giacomo C, Sorrenti V, Acquaviva R.(PubMed)
(2) African eggplant (Solanum anguivi Lam.) fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca(2+)-induced mitochondrial swelling by Elekofehinti OO1, Kamdem JP, Bolingon AA, Athayde ML, Lopes SR, Waczuk EP, Kade IJ, Adanlawo IG, Rocha JB. (PubMed)
Free radicals are unstable molecules with an unpaired electron in the outer ring. In order for them to become stable, free radicals always seek other atoms or molecules to bond to leading to domino's effect that cannot stop until they are either pair or inhibited by antioxidants
The continuation of this domino's effects is known to begin a process called oxidative stress. A prolonged period of overexpression of free radicals can cause oxidative stress, a major cause of some chronic diseases, including diabetes.
Truly, free radicals and oxidants play a dual role as both toxic and beneficial compounds. On the benefit side, according to Wanjek wrote in 2006, "The body's ability to turn air and food into chemical energy depends on a chain reaction of free radicals. Free radicals are also a crucial part of the immune system, floating through the veins and attacking foreign invaders".
Free radicals can promote toxicity to cancer cells, leading to antiproliferative and apoptotic effects without harming the nearby healthy cell if administration with dietary antioxidants or stimulated the production of antioxidants enzymes in the host through healthy food sources.
On the other hand, overexpression of free radical can be very harmful, Dr. Lien Ai Pham-Huy, the lead author in the study "Free Radicals, Antioxidants in Disease and Health" said, "When an overload of free radicals cannot gradually be destroyed, their accumulation in the body generates a phenomenon called oxidative stress. This process plays a major part in the development of chronic and degenerative illnesses such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular and neurodegenerative diseases".
"The human body has several mechanisms to counteract oxidative stress by producing antioxidants, which are either naturally produced in situ, or externally supplied through foods and/or supplements".
These analyses suggested that a healthy diet and lifestyle play a critical role in reducing the risk of imbalance of the ratio of free radicals and antioxidants by increasing the expression of antioxidants and decreasing the risk of overload of free radicals.
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India. The plant has been cultivated in southern and eastern Asia since prehistory.
It is famous for its deep purple and the best eggplant can be found from August through October when it is in season.
The vegetable chemical compounds include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.
In the reaffirming of the effects of eggplant rich source of polyphenol compounds endowed with antioxidant properties, researchers launched an evaluation to compare the antioxidant activity of the extract polyphenols from eggplant entire fruit, pulp, or skin, both fresh and dry and conventional extraction and microwave-assisted extraction (MAE).
In the time exposure 15, 30, 60, and 90 min) and solvent water 100% or ethanol/water, researchers found that 50% dry peeled skin treated with 50% aqueous ethanol, exerted a good antioxidant activity expressed by its capacity to scavenge superoxide anion and to inhibit lipid peroxidation compared to another eggplant extract.
Furthermore, in the evaluation of the antioxidant and radical scavenging activities of Solanum anguivi fruit (SAG)(Eggplant) and its possible effect on mitochondrial permeability transition pore as well as mitochondrial membrane potential (ΔΨm) isolated from rat liver, researchers showed that
* SAG exhibited potent and concentration-dependent free radical-scavenging activity (IC50/DPPH=275.03±7.8 μg/mL).
* Reductive and iron chelation abilities also increase with an increase in SAG concentration.
* SAG also inhibited peroxidation of cerebral and hepatic lipids subjected to iron oxidative assault.
The effect of eggplant in reducing the expression of free radical was attributed to the presence of major bioactive compounds, including gallic acid [(17.54±0.04) mg/g], chlorogenic acid (21.90±0.02 mg/g), caffeic acid (16.64±0.01 mg/g), rutin [(14.71±0.03) mg/g] and quercetin [(7.39±0.05) mg/g].
Dr. Elekofehinti OO, the lead scientist said, "SAG extract is a potential source of natural antioxidants that may be used not only in the pharmaceutical and food industry but also in the treatment of diseases associated with oxidative stress".
Taken all together, there is no doubt that eggplant processes a powerful antioxidants activity in the prevention of overexpression of free radical in the initiation of oxidative stress and combined with a primary theory for the treatment of oxidative stress-related diseases, depending on the confirmation of further data collection from the large example size and multi-center studies in human.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant activity and phenolic content of microwave-assisted Solanum melongena extracts by Salerno L, Modica MN, Pittalà V, Romeo G, Siracusa MA, Di Giacomo C, Sorrenti V, Acquaviva R.(PubMed)
(2) African eggplant (Solanum anguivi Lam.) fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca(2+)-induced mitochondrial swelling by Elekofehinti OO1, Kamdem JP, Bolingon AA, Athayde ML, Lopes SR, Waczuk EP, Kade IJ, Adanlawo IG, Rocha JB. (PubMed)
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