Kidneys, a pair of the bean-shaped organ in the human body only filter out blood but also balances the body fluids by eliminating them and remove them through urinary secretion.
Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.
Kidney disease is a medical condition that causes the reduced function of the kidney due to damage.
In other words, the progression of kidney damage may affect the function of the kidney to filter blood
against toxins.
Most patients with chronic kidney disease also found to have conditions of diabetes or high blood pressure.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness
In severe cases, patients may also have symptoms of shortness of breath, confusion, and irregular heartbeat.
The worse cases of kidney damage can lead to renal failure, a condition that induces wastes and toxins accumulated in the blood. In this stage, dialysis and kidney transplant are the only options.
Kidney damage can be classified into 4 different stages
* Stage 1 with normal or high GFR (GFR > 90 mL/min). In this stage of kidney patients are asymptomatic.
* Stage 2 Mild CKD (GFR = 60-89 mL/min), Patients in this stage also experience no symptoms.
*Stage 3A Moderate CKD (GFR = 45-59 mL/min) and 3B moderate CKD (GFR = 30-44 mL/min.
Most patients are asymptomatic. However, some patients may experience symptoms of mild swelling in the hands and feet, back pain and urinating more or less than normal.
* Stage 4 CKD (GFR = 15-30 mL/min). Most patients in this stage experience more severe symptoms of swelling in the hands and feet, back pain and urinating more or less than normal, accompanied by other health problem associated with weakened kidney function
* Stage 5 EndStage CKD (GFR <15 mL/min). Patients at this advanced stage are very close to renal failure or renal failure. Symptoms are getting worse.
Where eGFR is short for estimated glomerular filtration rate.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of kidney disease, researchers examined the effects of Withania somnifera on rats-induced nephrotoxicity.
The study included selected rat oral administrated by The root extract of three different doses of W. somnifera (viz., 250, 500, and 750 mg/kg) for 14 days before GEN treatment and thereafter concurrently with GEN (100 mg/kg) for 8 days.
Based on the tested differentiation, GEN treatment group showed significant nephrotoxicity associated with kidney injury by an increase in kidney weight, urea, creatinine, urinary protein, and glucose, and a significant reduction in body weights and potassium by enhancing the overexpression of free radicals.
Compared to somnifera doses of W. somnifera at 250 and 750 mg/kg, the administration of 500 mg/kg showed the strongest effect in reversing the aforementioned changed observed by the microscopically antioxidant evidence.
In other words, W. somnifera protected the kidney against acute toxicity in a dose-dependent manner.
However, there were no significant changes in the levels of sodium in the experimental animals compared to control.
Based on the findings, researchers said, "nephroprotective effect of Withania somnifera, which could be by enhancing antioxidant activity with natural antioxidants and scavenging the free radicals".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of periodontitis, pending to the result of larger sample size and multicenter study
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of Withania somnifera root powder on lipid peroxidation and antioxidant status in gentamicin-induced nephrotoxic rats by Jeyanthi T1, Subramanian P. (PubMed)
(2) Nephroprotective effect of Withania somnifera: a dose-dependent study by Jeyanthi T1, Subramanian P. (PubMed)
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