Herbal Chamomile may have a potential effect in reducing the risk and treatment of anxiety disorder, according to studies.
Anxiety disorders are a group of mental illnesses characterized by symptoms of excessive anxiety, fear, worry, avoidance, and compulsive rituals. The condition is more commonly in women than in men.
Some researchers suggested that anxiety disorders are conditions associated with the combination of biological, psychological, and individual factors and the most commonly reported psychiatric conditions and frequently occur as comorbid disorders.
According to the statistic, anxiety disorders are the most common mental illness in the U.S., affecting 40 million adults in the age of 18 and older, or 18.1% of the population every year.
The exact causes of anxiety disorders are debatable. However, a family history of anxiety recent or prolonged exposure to stress, excessive consumption of stimulants such as caffeine or tobacco is associated with the onset of the disorders.
The symptoms of anxiety disorders can be psychological or physical, including difficulty concentrating and sleeping, irritability, persistent stomachaches or diarrhea, sweaty palms, shaking and rapid heartbeat.
If you experience some of the above symptoms, please make sure you check with your doctor to rule out the possibility.
Dr. Lykouras L, the lead scientist in the investigation of the connection between body weight and anxiety disorders wrote, "Obesity has been associated with anxiety disorders as follows: most of the studies show a positive relationship with panic disorder, mainly in women, with specific phobia and social phobia" and "Some authors have found a relationship with generalized anxiety disorder but a negative relationship has been also reported".
The results clearly indicated if you are obese, your risk of anxiety disorders is increased substantially compared to normal-weight people.
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and for the treatment of menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
In a randomized, double-blind, placebo-controlled efficacy and tolerability trial of Matricaria recutita (chamomile) extract on generalized anxiety disorder (GAD) showed to effective of modest anxiolytic activity with patient mild to moderate GAD(1). The University of Ottawa study on the effects of Matricaria recutita (German chamomile) and Humulus lupulus (hops) showed significant activity in the inhibition of GAD at doses of 0.11-0.65 mg/mL(2).
The study containing 57 participants in the 2009 trial, 19 had anxiety with comorbid depression; 16 had anxiety with a past history of depression, and 22 had anxiety with no current or past depression, chamomile showed a clinically meaningful antidepressant activity to its previously observed anxiolytic activity(3).
Apigenin, a component of Matricaria recutita flowers, in mice study, exerted its anxiolytic and slight sedative effects through the central benzodiazepine receptors(4).
Researchers at the University Science Center on finding a treatment of anxiety disorder examined the effects of chamomile extract therapy in patients with mild to moderate generalized anxiety disorder (GAD) on a randomized, double-blind, placebo-controlled efficacy and tolerability trial.
In a total of 63 outpatients with mild to moderate GAD enrolled, 57 were randomized to either double-blind chamomile extract (n = 28) or placebo therapy (n = 29) for 8 weeks.
The chamomile treated group exerted a significantly greater reduction in mean total HAM-A score compared to the placebo.
Furthermore, besides the better primary outcomes, the chamomile group also demonstrated a positive change in all secondary outcomes in the reduction of anxiety symptoms.
Mild and tolerated adverse events or more were not significantly different between groups.
The findings clearly suggested herbal chamomile extract processes a modest anxiolytic activity in patients with mild to moderate GAD.
Moreover, in the evaluation of the chamomile effect on gamma-aminobutyric acid (GABA) which is a neurotransmitter that blocks impulses between nerve cells in the brain researchers compared the herbal plants which were used in the traditional medicine for the treatment of anxiety disorders.
Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter has been found to initiate the risk of anxiety or mood disorders in low levels
In vitro rat brain homogenate assays, compared to other herbal plants such as Melissa officinalis, Centella Asiatica (Gotu Kola) and Valeriana officinalis (Valerian), chamomile showed significant inhibition of glutamic acid decarboxylase (GAD) activity (0.11-0.65 mg/mL).
These results strongly suggested that the failure of the interaction of members in the GAGA system caused by dysfunction was attributed to the onset of anxiety disorders.
Additionally, in participants with symptoms of comorbid anxiety and depression, according to the generalized estimating equations analysis to identify clinically meaningful changes over time in scores from the Hamilton Depression Rating (HAM-D) questionnaire among treatment groups, Chamomile group displays a significantly greater reduction over time in total HAM-D scores compared to placebo.
Also, the HAM-D core mood item scores, application of chamomile also showed a significantly greater reduction over time vs placebo in all participants, regardless of the current or past depression.
Taken altogether, herbal chamomile may be considered a functional remedy for the prevention of anxiety disorders in the higher-risk populations and combined with primary medicine for the treatment of anxiety diseases with tolerated adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder by Amsterdam JD1, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J.(PubMed)
(2) Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system by Awad R1, Levac D, Cybulska P, Merali Z, Trudeau VL, Arnason JT. (PubMed)
(3) Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study by Amsterdam JD1, Shults J, Soeller I, Mao JJ, Rockwell K, Newberg AB. (PubMed)
(4) Anxiety disorders and obesity by Lykouras L1, Michopoulos J. (PubMed)
Saturday, February 1, 2020
Chaste Tree Berry Reduced Symptoms of Pain in Severe Primary Dysmenorrhea
Chaste tree berry may have a potential effect in ameliorated the symptoms of severe uterine pain in women with primary dysmenorrhea.
Dysmenorrhea (painful menstruation) is a condition of severe uterine pain during menstruation. Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen as resulting of overproduction of certain hormones in the prostaglandins family
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
According to the Nenehatun Hospital, In animal models, Chaste tree berry treatment significantly reduced symptoms of severe primary dysmenorrhea in the end of the third month of therapy.
In a total of 60 women with severe primary dysmenorrhea and 30 healthy women (control) included in this study. 30 patients treated with Ethinyl estradiol 0.03 mg/drospirenone (group 1) and another 30 treated with Fructus agni casti (group 2) during three menstrual cycles using the visual analog scale (VAS) scores, pulsatility index (PI), herbal plant treated group showed a higher mean PI and RI values in patients with severe primary dysmenorrhea in compared control groups on the first day of the first menstrual cycle (P < 0.0001) but the means of both values were significantly lower after the treatment in both groups compared to before values (P < 0.001 for both),
Additionally, researchers also found an increased uterine blood flow but no significant differences in terms of Doppler findings between groups 1 and 2, as women with severe symptoms of primary dysmenorrhea exhibited normally a high impedance to blood flow in uterine arteries with a preserved cyclic pattern throughout the whole cycle.
Dr. Aksoy AN, the lead author in the study said, "The effectiveness of Fructus agni casti was similar to that of ethinyl estradiol/drospirenone in patients with primary dysmenorrhea"
Other researchers also insisted that the efficacy of Chaste tree berry in reduced pain may be associated with the antinociceptive and analgesic activities, according to the petroleum ether fraction (PEF) from the aqueous ethanol extract of Vitex negundo Linn. (Verbenaceae) seeds injection into mice study conducted by the Second Military Medical University.
More importantly, another member of the Vitex group such as Vitex doniana extract may also have an effect in reduced uterine pain through regulating the hormone production of prostaglandins, ergometrine, and oxytocin which are found to have direct involvement of uterine muscle contractions.
Taking together, Chaste tree berry may be a potential herbal medicine for the treatment of painful symptoms in women with severe primary dysmenorrhea involved many mechanisms, including the antinociceptive, analgesic, hormone-regulated properties.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Evaluation of the efficacy of Fructus agni casti in women with severe primary dysmenorrhea: a prospective comparative Doppler study by Aksoy AN1, Gözükara I, Kabil Kucur S.(PubMed)
(2) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP.(PubMed)
(3) Activity of aqueous extract of the bark of Vitex doniana on uterine muscle response to drugs by Ladeji O1, Udoh FV, Okoye ZS.(PubMed)
Dysmenorrhea (painful menstruation) is a condition of severe uterine pain during menstruation. Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen as resulting of overproduction of certain hormones in the prostaglandins family
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
According to the Nenehatun Hospital, In animal models, Chaste tree berry treatment significantly reduced symptoms of severe primary dysmenorrhea in the end of the third month of therapy.
In a total of 60 women with severe primary dysmenorrhea and 30 healthy women (control) included in this study. 30 patients treated with Ethinyl estradiol 0.03 mg/drospirenone (group 1) and another 30 treated with Fructus agni casti (group 2) during three menstrual cycles using the visual analog scale (VAS) scores, pulsatility index (PI), herbal plant treated group showed a higher mean PI and RI values in patients with severe primary dysmenorrhea in compared control groups on the first day of the first menstrual cycle (P < 0.0001) but the means of both values were significantly lower after the treatment in both groups compared to before values (P < 0.001 for both),
Additionally, researchers also found an increased uterine blood flow but no significant differences in terms of Doppler findings between groups 1 and 2, as women with severe symptoms of primary dysmenorrhea exhibited normally a high impedance to blood flow in uterine arteries with a preserved cyclic pattern throughout the whole cycle.
Dr. Aksoy AN, the lead author in the study said, "The effectiveness of Fructus agni casti was similar to that of ethinyl estradiol/drospirenone in patients with primary dysmenorrhea"
Other researchers also insisted that the efficacy of Chaste tree berry in reduced pain may be associated with the antinociceptive and analgesic activities, according to the petroleum ether fraction (PEF) from the aqueous ethanol extract of Vitex negundo Linn. (Verbenaceae) seeds injection into mice study conducted by the Second Military Medical University.
More importantly, another member of the Vitex group such as Vitex doniana extract may also have an effect in reduced uterine pain through regulating the hormone production of prostaglandins, ergometrine, and oxytocin which are found to have direct involvement of uterine muscle contractions.
Taking together, Chaste tree berry may be a potential herbal medicine for the treatment of painful symptoms in women with severe primary dysmenorrhea involved many mechanisms, including the antinociceptive, analgesic, hormone-regulated properties.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Evaluation of the efficacy of Fructus agni casti in women with severe primary dysmenorrhea: a prospective comparative Doppler study by Aksoy AN1, Gözükara I, Kabil Kucur S.(PubMed)
(2) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP.(PubMed)
(3) Activity of aqueous extract of the bark of Vitex doniana on uterine muscle response to drugs by Ladeji O1, Udoh FV, Okoye ZS.(PubMed)
Herbal Cat's claw, The Whole Herb Medicine for Improving Immune Activities
In breast cancer patients, Uncaria tomentosa exhibited its bioactive immunomodulators' effects in regulating the immune system against irregular cell growth and inflammation.
Immunomodulatory compounds exerted the above properties found in the cat's claw include ajoene, arctigenin, β-carotene, curcumin, epigallocatechin-3-gallate, ginseng, glabridin and quinic acid, according to Dr. Baraya YS, the lead researcher.
A herbal immunomodulators review, in vitro and in vivo, also suggested, cats claw expressed the regulation of informational molecules such as cytokines through the alternation of immune function. Therefore, the medical plant may be a potential therapeutic modality for the treatment of many different conditions involving cytokine, including inflammation and autoimmune diseases.
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
Autoimmune diseases are the disorder caused by the immune system attacks the body healthy cells.
Cat's claw (Uncaria tomentosa) may be the next medical plant used for the treatment of autoimmune diseases through its stimulated immune effects.
Severe dengue is a disease associated to the changes in the endothelial barrier function due to the production of inflammatory mediators by immune cells, U. tomentosa exerted antiviral and immunomodulatory activities in inhibition of antigen and proinflammatory cytokine.
In fact, the significant effect in immunomodulation may introduce Cat's claw, as a promising candidate for clinical application.
The use of this herbal plant should be taken with care as toxicity has been found in some cases of overdoses.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Uncaria tomentosa increases growth and immune activity in Oreochromis niloticus challenged with Streptococcus agalactiae by Yunis-Aguinaga J1, Claudiano GS2, Marcusso PF2, Manrique WG2, de Moraes JR3, de Moraes FR4, Fernandes JB1.(PubMed)
(2) The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review by Baraya YS1, Wong KK2, Yaacob NS3.(PubMed)
(3) Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators by Spelman K1, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M.(PubMed)
(4) Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2 by Reis SR1, Valente LM, Sampaio AL, Siani AC, Gandini M, Azeredo EL, D'Avila LA, Mazzei JL, Henriques Md, Kubelka CF.(PubMed)
(5) Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis by Valerio LG Jr1, Gonzales GF.(PubMed)
Immunomodulatory compounds exerted the above properties found in the cat's claw include ajoene, arctigenin, β-carotene, curcumin, epigallocatechin-3-gallate, ginseng, glabridin and quinic acid, according to Dr. Baraya YS, the lead researcher.
A herbal immunomodulators review, in vitro and in vivo, also suggested, cats claw expressed the regulation of informational molecules such as cytokines through the alternation of immune function. Therefore, the medical plant may be a potential therapeutic modality for the treatment of many different conditions involving cytokine, including inflammation and autoimmune diseases.
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
Autoimmune diseases are the disorder caused by the immune system attacks the body healthy cells.
Cat's claw (Uncaria tomentosa) may be the next medical plant used for the treatment of autoimmune diseases through its stimulated immune effects.
Severe dengue is a disease associated to the changes in the endothelial barrier function due to the production of inflammatory mediators by immune cells, U. tomentosa exerted antiviral and immunomodulatory activities in inhibition of antigen and proinflammatory cytokine.
In fact, the significant effect in immunomodulation may introduce Cat's claw, as a promising candidate for clinical application.
The use of this herbal plant should be taken with care as toxicity has been found in some cases of overdoses.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Uncaria tomentosa increases growth and immune activity in Oreochromis niloticus challenged with Streptococcus agalactiae by Yunis-Aguinaga J1, Claudiano GS2, Marcusso PF2, Manrique WG2, de Moraes JR3, de Moraes FR4, Fernandes JB1.(PubMed)
(2) The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review by Baraya YS1, Wong KK2, Yaacob NS3.(PubMed)
(3) Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators by Spelman K1, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M.(PubMed)
(4) Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2 by Reis SR1, Valente LM, Sampaio AL, Siani AC, Gandini M, Azeredo EL, D'Avila LA, Mazzei JL, Henriques Md, Kubelka CF.(PubMed)
(5) Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis by Valerio LG Jr1, Gonzales GF.(PubMed)
Friday, January 31, 2020
Herbal Catnip in Reducing the Risk and Treatment of Breast Cancer
Herbal catnip may have a potential and substantial effect in reduced risk and treatment of breast cancer, some scientists suggested.
Catnip is also known as catswort, or catmint, a plant of Nepeta, belongings to the family of Lamiaceae, native to Europe and Asia, use in herbal medicine as insect repellent and to treat digestive disorders, children restlessness and nervousness, fevers, colds and flu, skin irritations stimulate sweating, promote menstruation, etc..
Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc..
Breast cancer is a medical condition characterized by irregular cell growth in the tissue of the breast. At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistics, approximately 1 in 8 U.S. women (about 12.4%) will develop invasive breast cancer over the course of their lifetime.
In a comparison of breast cancer cell lines (MCF-7, MDA-MB-231) to the non-cancer line (MCF-10A) to evaluate the cytotoxic and apoptogenic activity of EtOH 70%, hexane and aqueous extracts isolated from the herbal plant catnip, researchers showed that catnip inhibited the growth of malignant cells in a time and dose-dependent manner.
The hexane extract induced greater cytotoxicity in precipitated cancer cell apoptosis in compared to other extracts.
Further analysis, also indicated that at a dose of 60 μg/ml concentration of catnip hexane extract reduced the expression of mRNA of ornithine decarboxylase 1 in response to growth-promoting stimuli and exhibited a high turnover rate of breast cancer.
Over expressions of mRNA of tumor ornithine decarboxylase levels heterogeneity found in breast cell lines were associated to significantly increase the mean of tumor malignancy by 4.9 and 3.6 fold of adenosine deaminase, an E2 responsive in MCF-7 human breast cancer cells and by 3.5 and 2.6 in MCF-7 cell line and MDA-MB-231 cell line, respectively and in compared to control.
Tumor ornithine decarboxylase gene is also considered as a biomarker as a prognostic factor for breast cancer. Increased serum of adenosine deaminase is found to correlate to cancer progression and malignancy.
The results indicated that the application of catnip methanol hexane extract scores a high potential in modulating the expression of ornithine decarboxylase 1 and adenosine deaminase genes in breast cancer cells in inhibiting malignant cancer proliferation and induced apoptosis.
Moreover, the investigation of the anticancer activities of chloroform Nepeta deflersiana extract and various sub-fractions (ND-1-ND-15) of ND against human breast cancer cells (MCF-7) by the King Saud University suggested that applications of selected sub-fractions of the chloroform extract at dose of 10-1000 μg/ml for 24 hours, displays a significant reduction of the cell viability of MCF-7 cancer cell line and altered the cellular morphology in a concentration-dependent manner.
Additional analysis indicated that N-10 isolated from catnip expressed greater cytotoxicity in induced cancer death compared to other fractions according to the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay.
According to the neutral red uptake assay, ND-1 extract did not cause any cytotoxicity in MCF-7 cells exposed for 24 h. However, the ND-10 extract was found more toxic toward breast cancer cells.
Finally, in MCF-7 cells, application at doses at 500 and 1000 μg/ml concentrations of all extracts exhibited a huge activity on in reduced the normal morphology of the cells and cell adhesion capacity compared to the control.
And most of the breast cancer cells at 1000 μg/ml concentration lost their typical morphology and appeared smaller in size and shrunken.
Compared to cancer cell line A-549 cells, MCF-7 cells were less sensitive to growth inhibition by all the extracts.
Taken together, there is no doubt that catnip and its methanol extracts may be a potential and therapeutic source of pharmacologically active molecules for the development of the chemotherapeutic drug for the treatment of breast cancer.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Growth inhibition of human breast cancer cells and down-regulation of ODC1 and ADA genes by Nepeta binaloudensis by Akbar Safipour, Afshar Fatemeh Saeid Nematpour, Mahshid Meshkani, and ArezosadatKhafi(Science Direct)
(2) Anticancer Activity of Chloroform Extract and Sub-fractions of Nepeta deflersiana on Human Breast and Lung Cancer Cells: An In vitro Cytotoxicity Assessment by Al-Oqail MM1, Al-Sheddi ES1, Siddiqui MA2, Musarrat J2, Al-Khedhairy AA2, Farshori NN1.(PubMed)
Catnip is also known as catswort, or catmint, a plant of Nepeta, belongings to the family of Lamiaceae, native to Europe and Asia, use in herbal medicine as insect repellent and to treat digestive disorders, children restlessness and nervousness, fevers, colds and flu, skin irritations stimulate sweating, promote menstruation, etc..
Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc..
Breast cancer is a medical condition characterized by irregular cell growth in the tissue of the breast. At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistics, approximately 1 in 8 U.S. women (about 12.4%) will develop invasive breast cancer over the course of their lifetime.
In a comparison of breast cancer cell lines (MCF-7, MDA-MB-231) to the non-cancer line (MCF-10A) to evaluate the cytotoxic and apoptogenic activity of EtOH 70%, hexane and aqueous extracts isolated from the herbal plant catnip, researchers showed that catnip inhibited the growth of malignant cells in a time and dose-dependent manner.
The hexane extract induced greater cytotoxicity in precipitated cancer cell apoptosis in compared to other extracts.
Further analysis, also indicated that at a dose of 60 μg/ml concentration of catnip hexane extract reduced the expression of mRNA of ornithine decarboxylase 1 in response to growth-promoting stimuli and exhibited a high turnover rate of breast cancer.
Over expressions of mRNA of tumor ornithine decarboxylase levels heterogeneity found in breast cell lines were associated to significantly increase the mean of tumor malignancy by 4.9 and 3.6 fold of adenosine deaminase, an E2 responsive in MCF-7 human breast cancer cells and by 3.5 and 2.6 in MCF-7 cell line and MDA-MB-231 cell line, respectively and in compared to control.
Tumor ornithine decarboxylase gene is also considered as a biomarker as a prognostic factor for breast cancer. Increased serum of adenosine deaminase is found to correlate to cancer progression and malignancy.
The results indicated that the application of catnip methanol hexane extract scores a high potential in modulating the expression of ornithine decarboxylase 1 and adenosine deaminase genes in breast cancer cells in inhibiting malignant cancer proliferation and induced apoptosis.
Moreover, the investigation of the anticancer activities of chloroform Nepeta deflersiana extract and various sub-fractions (ND-1-ND-15) of ND against human breast cancer cells (MCF-7) by the King Saud University suggested that applications of selected sub-fractions of the chloroform extract at dose of 10-1000 μg/ml for 24 hours, displays a significant reduction of the cell viability of MCF-7 cancer cell line and altered the cellular morphology in a concentration-dependent manner.
Additional analysis indicated that N-10 isolated from catnip expressed greater cytotoxicity in induced cancer death compared to other fractions according to the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay.
According to the neutral red uptake assay, ND-1 extract did not cause any cytotoxicity in MCF-7 cells exposed for 24 h. However, the ND-10 extract was found more toxic toward breast cancer cells.
Finally, in MCF-7 cells, application at doses at 500 and 1000 μg/ml concentrations of all extracts exhibited a huge activity on in reduced the normal morphology of the cells and cell adhesion capacity compared to the control.
And most of the breast cancer cells at 1000 μg/ml concentration lost their typical morphology and appeared smaller in size and shrunken.
Compared to cancer cell line A-549 cells, MCF-7 cells were less sensitive to growth inhibition by all the extracts.
Taken together, there is no doubt that catnip and its methanol extracts may be a potential and therapeutic source of pharmacologically active molecules for the development of the chemotherapeutic drug for the treatment of breast cancer.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Growth inhibition of human breast cancer cells and down-regulation of ODC1 and ADA genes by Nepeta binaloudensis by Akbar Safipour, Afshar Fatemeh Saeid Nematpour, Mahshid Meshkani, and ArezosadatKhafi(Science Direct)
(2) Anticancer Activity of Chloroform Extract and Sub-fractions of Nepeta deflersiana on Human Breast and Lung Cancer Cells: An In vitro Cytotoxicity Assessment by Al-Oqail MM1, Al-Sheddi ES1, Siddiqui MA2, Musarrat J2, Al-Khedhairy AA2, Farshori NN1.(PubMed)
Herbal Burdock, The Natural Remedy Which Processes Anti- Inflammatory Activity
Scientists may have found a medicinal plant for the prevention and treatment of chronic inflammatory diseases with no side effects, according to studies.
Inflammation is a natural response of the human body against the foreign pathogens and stimuli that progress through many phases.
In the acute phase of infection, the immune white blood cells in the first line of defense stimulating the blood vessel constriction and palette accumulated to the injury area to cover the wound and the proteins associated with the production of the pro-inflammatory cytokines to kill off the invasive microorganisms.
In people with a strong immune system, during the acute phase of infection, the levels of pro-inflammatory cytokines are balanced by the expression of anti-inflammatory cytokines without affecting the immune activity.
However, in children, the elderly and people with the weakened immune system, overexpression of proinflammatory cytokines can damage the nearby cells and tissue, leading to the formation of scars.
Chronic inflammation is a medical disease caused by the immune inability to destroy the invaders in the acute phase of infection, leading to the immune system in the adaption of the change.
Over time, chronic inflammation can have a strongly negative impact on the affected tissues and organs.
Other causes of chronic inflammation also include an autoimmune disorder, in which the immune system mistakenly attacking healthy tissue and long-term exposure to irritants, such as industrial chemicals or polluted air.
People with chronic inflammatory diseases such as "Rheumatoid arthritis (RA) is associated with accelerated vascular risk resulting in an increased prevalence of CAD with attendant early mortality and excess morbidity" Dr, Abou-Raya S and colleagues at the University of Alexandria, Alexandria, wrote, " The implication is that inflammation may be the central link between the chronic inflammatory autoimmune disorders and atherosclerosis".
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. It has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
The ingredients of herbal Burdock include carbonated water, sugar,, manloid colorings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.
With an aim to find a natural ingredient for the treatment of atopic dermatitis is a chronic, allergic inflammatory skin disease, researchers examined whether a butanol extract of A. lappa (ALBE) had previously unreported anti-allergic or anti-inflammatory effects.
On ConA-treated primary murine splenocytes, ALBE demonstrated significant inhibition of β-hexosaminidase release in RBL-2H3 cells by suppressing the mRNA expression in transmitting information between cells associated to the β-hexosaminidase release and proteins involved the production of inflammatory cytokines.
ALBE (100 μg/mL) suppressed not only the protein complex associated with transcription of DNA, cytokine production but also the pathway involved the regulation of pro-inflammatory cytokines in Concanavalin A (ConA) treated primary splenocytes.
Where Concanavalin-A is a lectin used in the experiment to trigger inflammatory responses.
Furthermore, in an experimental colitis model induced by 2,4,6 trinitrobenzene sulfonic acid, researchers evaluated ONP fraction (25 and 50 mg/kg/day) orally administered 48, 24 and 1 h prior to the induction of colitis and 24 h after.
Before the application of ONP, TNBS treatment group showed an increased colonic wall thickness, edema, diffuse inflammatory cell infiltration, observed by the increased production of inflammatory cytokines and enzymes.
Contrarily, ONP fraction (25 and 50 mg/kg) treatment significantly reduced the macroscopic inflammation scores (p<0.05 and p<0.01, respectively) and morphological alterations associated with an increase in the mucus secretion.
Injection of ONP fraction at 25 and 50 mg/kg also expressed significantly reduced levels of neutrophil infiltration and the cytokines, through their anti-inflammatory and antioxidant activities.
Compared to COX-2 overexpression of inflammation and pain in TNBS-treated rats, ONP fraction (50 mg/kg) administration reduced COX-2 overexpression.
The findings suggested that herbal Burdock fraction obtained from Arctium lappa processed gastrointestinal protective effects against acute colitis.
Taken altogether, herbal Burdock may be considered a functional herb for the prevention and combined with the primary medicine for the treatment of acute and chronic inflammatory diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-allergic and anti-inflammatory effects of butanol extract from Arctium Lappa L.
Sohn EH, Jang SA, Joo H, Park S, Kang SC, Lee CH, Kim SY.(PubMed)
(2) Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model. by de Almeida AB, Sánchez-Hidalgo M, Martín AR, Luiz-Ferreira A, Trigo JR, Vilegas W, dos Santos LC, Souza-Brito AR, de la Lastra CA.(PubMed)
(3) In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway by Zhao F, Wang L, Liu K.(PubMed)
(4) Chronic inflammatory autoimmune disorders and atherosclerosis by Abou-Raya S1, Abou-Raya A, Naim A, Abuelkheir H. (PubMed)
Inflammation is a natural response of the human body against the foreign pathogens and stimuli that progress through many phases.
In the acute phase of infection, the immune white blood cells in the first line of defense stimulating the blood vessel constriction and palette accumulated to the injury area to cover the wound and the proteins associated with the production of the pro-inflammatory cytokines to kill off the invasive microorganisms.
In people with a strong immune system, during the acute phase of infection, the levels of pro-inflammatory cytokines are balanced by the expression of anti-inflammatory cytokines without affecting the immune activity.
However, in children, the elderly and people with the weakened immune system, overexpression of proinflammatory cytokines can damage the nearby cells and tissue, leading to the formation of scars.
Chronic inflammation is a medical disease caused by the immune inability to destroy the invaders in the acute phase of infection, leading to the immune system in the adaption of the change.
Over time, chronic inflammation can have a strongly negative impact on the affected tissues and organs.
Other causes of chronic inflammation also include an autoimmune disorder, in which the immune system mistakenly attacking healthy tissue and long-term exposure to irritants, such as industrial chemicals or polluted air.
People with chronic inflammatory diseases such as "Rheumatoid arthritis (RA) is associated with accelerated vascular risk resulting in an increased prevalence of CAD with attendant early mortality and excess morbidity" Dr, Abou-Raya S and colleagues at the University of Alexandria, Alexandria, wrote, " The implication is that inflammation may be the central link between the chronic inflammatory autoimmune disorders and atherosclerosis".
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. It has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
The ingredients of herbal Burdock include carbonated water, sugar,, manloid colorings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.
With an aim to find a natural ingredient for the treatment of atopic dermatitis is a chronic, allergic inflammatory skin disease, researchers examined whether a butanol extract of A. lappa (ALBE) had previously unreported anti-allergic or anti-inflammatory effects.
On ConA-treated primary murine splenocytes, ALBE demonstrated significant inhibition of β-hexosaminidase release in RBL-2H3 cells by suppressing the mRNA expression in transmitting information between cells associated to the β-hexosaminidase release and proteins involved the production of inflammatory cytokines.
ALBE (100 μg/mL) suppressed not only the protein complex associated with transcription of DNA, cytokine production but also the pathway involved the regulation of pro-inflammatory cytokines in Concanavalin A (ConA) treated primary splenocytes.
Where Concanavalin-A is a lectin used in the experiment to trigger inflammatory responses.
Furthermore, in an experimental colitis model induced by 2,4,6 trinitrobenzene sulfonic acid, researchers evaluated ONP fraction (25 and 50 mg/kg/day) orally administered 48, 24 and 1 h prior to the induction of colitis and 24 h after.
Before the application of ONP, TNBS treatment group showed an increased colonic wall thickness, edema, diffuse inflammatory cell infiltration, observed by the increased production of inflammatory cytokines and enzymes.
Contrarily, ONP fraction (25 and 50 mg/kg) treatment significantly reduced the macroscopic inflammation scores (p<0.05 and p<0.01, respectively) and morphological alterations associated with an increase in the mucus secretion.
Injection of ONP fraction at 25 and 50 mg/kg also expressed significantly reduced levels of neutrophil infiltration and the cytokines, through their anti-inflammatory and antioxidant activities.
Compared to COX-2 overexpression of inflammation and pain in TNBS-treated rats, ONP fraction (50 mg/kg) administration reduced COX-2 overexpression.
The findings suggested that herbal Burdock fraction obtained from Arctium lappa processed gastrointestinal protective effects against acute colitis.
Taken altogether, herbal Burdock may be considered a functional herb for the prevention and combined with the primary medicine for the treatment of acute and chronic inflammatory diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-allergic and anti-inflammatory effects of butanol extract from Arctium Lappa L.
Sohn EH, Jang SA, Joo H, Park S, Kang SC, Lee CH, Kim SY.(PubMed)
(2) Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model. by de Almeida AB, Sánchez-Hidalgo M, Martín AR, Luiz-Ferreira A, Trigo JR, Vilegas W, dos Santos LC, Souza-Brito AR, de la Lastra CA.(PubMed)
(3) In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway by Zhao F, Wang L, Liu K.(PubMed)
(4) Chronic inflammatory autoimmune disorders and atherosclerosis by Abou-Raya S1, Abou-Raya A, Naim A, Abuelkheir H. (PubMed)
Cat's Claw, the Best Whole Herb medicine for Prevention and Treatment of Colorectal cancer
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Bowel cancer also is known as colorectal cancer, is a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided into 2 parts, the first part of the bowel, the small bowel, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consists of the colon and rectum, is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.
Cat's Claw extract may have a role for cancer patients as a complementary therapy. According to the joint study led by the Federal University of Santa Maria (UFSM), Cat's Claw enhanced chemotherapy-induced apoptosis, with interference in cell cycle division in colorectal adenocarcinoma cells (HT29 cells).
Dr. Gurrola-Díaz CM, the lead researchers at the Centro Universitario de Ciencias de la Salud (CUCS) suggested, the anti-inflammatory and anti-proliferative properties of different alkaloids extracted from Cat's Claw may be resulted of the interfering the proteins that pass signals into a cell through cell surface receptors. Uncaria tomentosa is less toxic in non-cancer cells than in cancer cells.
In a randomized clinical trial conducted of Patients (43) undergoing adjuvant/palliative chemotherapy, patients received chemotherapy plus 300 mg of Uncaria tomentosa daily, showed to reduce side effects of chemotherapy with no toxic effect.
Dr. Valerio LG Jr and Dr. Gonzales GF. in the review of the toxicological aspects of the South American herbs cat's claw said, " An important finding unveiled by this review is the importance of standardization in quality and additional basic and clinical research to scientifically validate and understand composition, biological activity, safety and risk" and " Development of a comprehensive pharmacological and toxicological profile through critical evaluation of existing and future experimental data... "
Therefore, the use of Cat's Claw as a whole herb medicine should be taken with care. The quantity intake can only be prescribed by professionals; herbalists.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis by Nogueira Neto J1, Cavalcante FL, Carvalho RA, Rodrigues TG, Xavier MS, Furtado PG, Schor E.(PubMed)
(2) Inhibitory mechanisms of two Uncaria tomentosa extracts affecting the Wnt-signaling pathway by Gurrola-Díaz CM1, García-López PM, Gulewicz K, Pilarski R, Dihlmann S.(PubMed)
(3) Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial by Farias IL1, Araújo MC, Farias JG, Rossato LV, Elsenbach LI, Dalmora SL, Flores NM, Durigon M, Cruz IB, Morsch VM, Schetinger MR.(PubMed)
(4) Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis by Valerio LG Jr1, Gonzales GF.(PubMed)
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Bowel cancer also is known as colorectal cancer, is a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided into 2 parts, the first part of the bowel, the small bowel, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consists of the colon and rectum, is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.
Cat's Claw extract may have a role for cancer patients as a complementary therapy. According to the joint study led by the Federal University of Santa Maria (UFSM), Cat's Claw enhanced chemotherapy-induced apoptosis, with interference in cell cycle division in colorectal adenocarcinoma cells (HT29 cells).
Dr. Gurrola-Díaz CM, the lead researchers at the Centro Universitario de Ciencias de la Salud (CUCS) suggested, the anti-inflammatory and anti-proliferative properties of different alkaloids extracted from Cat's Claw may be resulted of the interfering the proteins that pass signals into a cell through cell surface receptors. Uncaria tomentosa is less toxic in non-cancer cells than in cancer cells.
In a randomized clinical trial conducted of Patients (43) undergoing adjuvant/palliative chemotherapy, patients received chemotherapy plus 300 mg of Uncaria tomentosa daily, showed to reduce side effects of chemotherapy with no toxic effect.
Dr. Valerio LG Jr and Dr. Gonzales GF. in the review of the toxicological aspects of the South American herbs cat's claw said, " An important finding unveiled by this review is the importance of standardization in quality and additional basic and clinical research to scientifically validate and understand composition, biological activity, safety and risk" and " Development of a comprehensive pharmacological and toxicological profile through critical evaluation of existing and future experimental data... "
Therefore, the use of Cat's Claw as a whole herb medicine should be taken with care. The quantity intake can only be prescribed by professionals; herbalists.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis by Nogueira Neto J1, Cavalcante FL, Carvalho RA, Rodrigues TG, Xavier MS, Furtado PG, Schor E.(PubMed)
(2) Inhibitory mechanisms of two Uncaria tomentosa extracts affecting the Wnt-signaling pathway by Gurrola-Díaz CM1, García-López PM, Gulewicz K, Pilarski R, Dihlmann S.(PubMed)
(3) Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial by Farias IL1, Araújo MC, Farias JG, Rossato LV, Elsenbach LI, Dalmora SL, Flores NM, Durigon M, Cruz IB, Morsch VM, Schetinger MR.(PubMed)
(4) Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis by Valerio LG Jr1, Gonzales GF.(PubMed)
Thursday, January 30, 2020
Bromelain Suppresses Rheumatic Disease with No Side Effects
Rheumatism or rheumatic disorder is a group of medical conditions associated with chronic, often intermittent pain that affects the joints and/or connective tissue.
The most common symptoms of rheumatism are joint pain, loss of motion in a joint or joints and low-grade inflammation that causes swelling, redness, and warmth in a joint or affected area.
Most common types of rheumatism are
* Osteoarthritis (OA), a form of arthritis, is a condition of aging-induced wear and tears on a joint, affecting over 25 million people in the US.
* Rheumatoid arthritis (RA) is a chronic disorder associated with the inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. RA affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders.
* Gout mostly effected one joint is an acute and recurrent condition of arthritis caused by uric acid building up in the blood, inducing joint inflammation.
* Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
* Polymalagia arthritis is a condition of inflammatory rheumatic disease which causes pain, stiffness, and tenderness in large muscles, including muscle shoulders and pelvic girdle.
* Lupus is an autoimmune disease, caused by the immune system overreaction that attacks its tissues, causing inflammation, swelling, pain, and damage.
* Juvenile idiopathic arthritis (JIA) is the type of arthritis that occurs in children with symptoms of persistent joint swelling, pain, and stiffness
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of arthritis, researchers examined the effect of an oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) in the treatment of rheumatic diseases.
The retrospective cohort study with parallel groups was to compare the efficacy of enzyme combination to those of nonsteroidal anti-inflammatory drugs (NSAID).
According to the data of 3326 patients treated for rheumatic diseases in which 2139 patients were treated either only with OE or only with NSAID, between January 1993 and the end of March 1995 registered by 380 physicians, both treatments yielded similar results.
However, there was a 50% higher success rate in OE than for NSAID, compared to the initial and treatment situations.
OE also scored higher stratification according to propensity score.
Furthermore, treatment duration more than 30 days and joint diseases or fibromyalgias in age over 50 years, pre-treatment with antirheumatic or analgesic drugs showed significant negative effects in patients' response compared to those of OE.
Additionally, according to the aforementioned and other indicators associated with freedom from symptoms, OE exerted an expectation compared to NSAID treatment.
The results strongly support the use of the oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) for the treatment of rheumatic disease instead of NSAIDs
Dr. Wittenborg A, after taking other factors into account, wrote in the final report, "OE were well tolerated showing much less adverse events when compared with conventional doses of NSAID".
Taken altogether, bromelain combined with conventional medicine may be considered a remedy for the prevention and treatment of rheumatic disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review].[Article in German] by Heyll U1, Münnich U, Senger V. (PubMed)
(2) [Comparative epidemiological study in patients with rheumatic diseases illustrated in a example of a treatment with non-steroidal anti- inflammatory drugs versus an oral enzyme combination preparation].[Article in German] by Wittenborg A1, Bock PR, Hanisch J, Saller R, Schneider B. (PubMed)
(3) General Health by Kyle J. Norton
The most common symptoms of rheumatism are joint pain, loss of motion in a joint or joints and low-grade inflammation that causes swelling, redness, and warmth in a joint or affected area.
Most common types of rheumatism are
* Osteoarthritis (OA), a form of arthritis, is a condition of aging-induced wear and tears on a joint, affecting over 25 million people in the US.
* Rheumatoid arthritis (RA) is a chronic disorder associated with the inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. RA affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders.
* Gout mostly effected one joint is an acute and recurrent condition of arthritis caused by uric acid building up in the blood, inducing joint inflammation.
* Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
* Polymalagia arthritis is a condition of inflammatory rheumatic disease which causes pain, stiffness, and tenderness in large muscles, including muscle shoulders and pelvic girdle.
* Lupus is an autoimmune disease, caused by the immune system overreaction that attacks its tissues, causing inflammation, swelling, pain, and damage.
* Juvenile idiopathic arthritis (JIA) is the type of arthritis that occurs in children with symptoms of persistent joint swelling, pain, and stiffness
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of arthritis, researchers examined the effect of an oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) in the treatment of rheumatic diseases.
The retrospective cohort study with parallel groups was to compare the efficacy of enzyme combination to those of nonsteroidal anti-inflammatory drugs (NSAID).
According to the data of 3326 patients treated for rheumatic diseases in which 2139 patients were treated either only with OE or only with NSAID, between January 1993 and the end of March 1995 registered by 380 physicians, both treatments yielded similar results.
However, there was a 50% higher success rate in OE than for NSAID, compared to the initial and treatment situations.
OE also scored higher stratification according to propensity score.
Furthermore, treatment duration more than 30 days and joint diseases or fibromyalgias in age over 50 years, pre-treatment with antirheumatic or analgesic drugs showed significant negative effects in patients' response compared to those of OE.
Additionally, according to the aforementioned and other indicators associated with freedom from symptoms, OE exerted an expectation compared to NSAID treatment.
The results strongly support the use of the oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) for the treatment of rheumatic disease instead of NSAIDs
Dr. Wittenborg A, after taking other factors into account, wrote in the final report, "OE were well tolerated showing much less adverse events when compared with conventional doses of NSAID".
Taken altogether, bromelain combined with conventional medicine may be considered a remedy for the prevention and treatment of rheumatic disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review].[Article in German] by Heyll U1, Münnich U, Senger V. (PubMed)
(2) [Comparative epidemiological study in patients with rheumatic diseases illustrated in a example of a treatment with non-steroidal anti- inflammatory drugs versus an oral enzyme combination preparation].[Article in German] by Wittenborg A1, Bock PR, Hanisch J, Saller R, Schneider B. (PubMed)
(3) General Health by Kyle J. Norton
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