Friday, February 7, 2020

Healthy Food Cranberry, the Best in the Promotion of Oral Health


Gingivitis or gingival inflammation is one of the most common conditions of oral inflammation of the gum caused by overexpression of plaques accumulated on your teeth that irritate the gingiva. Over time, the gum of an infected person has become swollen and bleed easily.

In severe cases, the condition can lead to periodontal disease, inducing tooth decay or loss of the tooth.

Most of the cases of gingivitis are associated with poor hygiene, particularly in people who smoke.
Gingivitis can be reversed by following a good oral health habit, including brushing at least twice a day, flossing daily and getting regular dental checkups.

Other causes of the oral problem are poor diet and hygiene, trauma, stress, alcohol use, and use of illegal substances.

However, chronic diseases also are found to induce poor oral health, including diabetes.

Most common symptoms of gingivitis including swollen gums with dusky red or dark red color and bleeding easily when brush or floss, particularly breath-breath.

According to the statistics provided by the CDC, smoking is an important cause of severe gum disease in the US.

Some researchers suggested that long-term oral infection can place the patients at risk of certain chronic diseases.

Dr. Xiaojing Li, and colleagues wrote, "Recently, it has been recognized that oral infection, especially periodontitis, may affect the course and pathogenesis of a number of systemic diseases, such as cardiovascular disease, bacterial pneumonia, diabetes mellitus, and low birth weight".


And, "Periodontitis as a major oral infection may affect the host's susceptibility to systemic disease in three ways: by shared risk factors; subgingival biofilms acting as reservoirs of gram-negative bacteria; and the periodontium acting as a reservoir of inflammatory mediators".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of oral disease, researchers examined the effect of cranberry extracts on oral health, including dental caries and protection against periodontitis.

Cranberry fraction enriched in high molecular weight polyphenols from the A non-dialysable extract showed to inhibit cariogenic and periodontal pathogenic bacteria.


Diseases associated with oral inflammatory response and enzymes that degrade the extracellular matrix was also reduced upon the application of cranberry fraction.

Furthermore, according to tested differentiation, Cranberry components found in the extract also inhibited acid production, attachment, and biofilm formation by Streptococcus mutans.

Glucan-binding proteins associated with dental caries pathogen, extracellular enzymes secreted by the cell involved in a bacterial trait, and bacterial hydrophobicity were also affected by cranberry components.


In periodontal diseases, the cranberry fraction also exerted similarly aforementioned effects such as the host inflammatory responses, production, and activity of enzymes.

The findings strongly suggested that cranberry components found in cranberry worked synergistically, for the prevention and/or treatment of oral diseases, particularly in those of high molecular weight bioactive molecules.

Taken altogether, cranberry may be considered a remedy for the promotion of oral health, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Potential oral health benefits of cranberry by Bodet C1, Grenier D, Chandad F, Ofek I, Steinberg D, Weiss EI. (PubMed)
(2) Characterization of non-dialyzable constituents from cranberry juice that inhibit adhesion, co-aggregation and biofilm formation by oral bacteria by Neto CC1, Penndorf KA, Feldman M, Meron-Sudai S, Zakay-Rones Z, Steinberg D, Fridman M, Kashman Y, Ginsburg I, Ofek I, Weiss E. (PubMed)
(3) Systemic Diseases Caused by Oral Infection by Xiaojing Li,1,* Kristin M. Kolltveit,1 Leif Tronstad,2 and Ingar Olsen. (PMC)

The Best of Perennially Herbal Fennel In Ameliorated Risk, Progression and Treatment of Prostate cancer

Fennel may have potential and positive effect in reduced risk, progression and treatment of prostate cancer, some scientist suggested.

Prostate caner is a chronic condition characterized by abnormal growth of prostate tissue. At he later stage, the cancerous cells may travel a distance away to infect other healthy cells and tissues.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc

In the study to investigate the effect of 5 herbal medicine in different quantity in some different formulas represented by FB, FM, PP, HF and FBL101 in risk of prostate cancer, including licorice, black cohosh, Dong Quai, false unicorn and vitex berry root extracts, fennel seed extract, researchers at the National Institute of Health found that FB, FM, PP, HF and FBL101 inhibited PC3 tumor growth by 53%, 75%, 80%, 81% and 87%, respectively.

In an androgen-independent human prostate cancer cell line CWR22R, all 5 formulas also inhibited the cancer cell proliferation without alternating levels of testosterone.


However, the administration of formula PP and FBL101 showed a significantly reduced VEGF level with function in the stimulated formation of new blood vessels in initiated proliferation in PC3 and CWR22R tumors.



Furthermore, intratumoral microvessel density measurement in the expression of tumor growth with aggressive tumor behavior was decreased in PC3 tumors treated with all five supplements but only in CWR22R tumors treated with HF.

Dr. Ng SS, after taking into account other cofounders said, "herbal supplements containing the aforementioned extracts inhibit the growth of prostate tumor xenografts, possibly in part by antiangiogenic mechanisms".

These results demonstrated that fennel extract and other herbal components may be considered as preventive and therapeutic agents for the treatment of prostate cancer without indicating the efficacy of the individual herb.


The above differentiation was supported by the study of the Alexandria University in the evaluation of anethole, a major constituent of Foeniculum vulgare (fennel) essential oil, a widely used folk medicine for the treatment of prostate cancer.

According to the experiment, application of the bioactive compound anethole exerted a strong activity against proliferation, clonal growth, and migration of PC-3 cells, through the generation of ROS in the induction of cytotoxicity through damage to the DNA of the cancer cells.


Additional analysis of the efficacy, the application also stimulated the penetration of essential oil anethole in permeabilization of the mitochondrial and lysosomal membranes of PC3 cancer cells in the induction of cancer cells death, executed by caspase-3 and -9 pathways and PARP cleavage in the induction of apoptosis.

Interestingly, injection of anethole isolated from fennel essential oil also induced elevation of Bax/Bcl-2 protein ratio, in initiated the onset of prostate cancer cell death through cell cycle arrest.

Further observation of anethole action, researchers found that anethole inhibited prostate cancer cells through cell cycle arrest in G2/M phase ameliorated by levels of cyclins D1, CDK-4 and c-Myc proteins in promoted cancer cell cycle progression and enhanced production of levels p21 and p27 in exhibited tumor suppressible activity.


Finally, anethole also suppressed NF-κB protein in activated production of TNF-α in the induction of anti-apoptosis in prostate cancer cells.

Taken together, the findings strongly suggested that long term intake of fennel and its bioactive anethole may have substantial implications in the prevention and treatment of prostate cancer. But intake of fennel supplement should be taken with care to prevent acute liver toxicity.


For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Anethole Inhibits The Proliferation Of Human Prostate Cancer Cells Via Induction Of Cell Cycle Arrest And Apoptosis by Elkady A(PubMed).
(2) Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice by Ng SS1, Figg WD.(PubMed)

Thursday, February 6, 2020

Herbal Butterbur, The Best in the Promotion of Antioxidant Activity

Herbal Butterbur may be the potential target to extract a single ingredient for the treatment of oxidative stress, some scientists suggested.

Oxidative stress is either caused by overexpression free radicals compared to levels of antioxidant or suppression of the levels of antioxidant enzymes in the host body, compared to the expression of free radicals.

The imbalanced ratio of free radical and antioxidant enzymes produced by the host that counter the overexpression of free radicals has been found to facilitate the early onset of numbers of chronic ailments, such as cancers.

Free radicals are naturally produced from daily normal essential metabolic processes in the human body. However, some external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals can also increase the expression of free radicals in the body.

Free radicals are unstable molecules with the unpaired electron in the outer ring and ready to donate or steal an electron from another molecule, leading to the chain reaction until they are stopped by the presence of the antioxidants or their outer ring are paired.

Overexpression of free radical chain reactive in the human body has been known to induce oxidative stress, causing damage to the cells, proteins, and alternation of cell DNA. In this case, the application of an external source of antioxidants such as synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole may be helpful to restore the balance of these 2 types of molecule.

Hydroxyl radical, superoxide anion radical, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radical, and peroxynitrite radicals are hight reactive and important free radical associated with many chronic diseases.

Dr. V. Lobo, in the concern of the overexpression of free radicals in the induction of, vary human chronic illness conducted a study to examine the impacts of free radicals, antioxidants and functional foods in human health said in summary, "Free radicals damage contributes to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataract, and cancer. Antioxidants prevent free radical-induced tissue damage by preventing the formation of radicals, scavenging them, or by promoting their decomposition".

(More importantly)" Synthetic antioxidants are recently reported to be dangerous to human health. Thus the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years. In addition to endogenous antioxidant defense systems, consumption of dietary and plant-derived antioxidants appears to be a suitable alternative. Dietary and other components of plants form a major source of antioxidants".

Butterbur, found in wet, marshy, damp land, including wetland, Riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.

The herbal plant has been used in traditional medicine as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.

The chemical constituents of Butterbur include Petioles, petasitene, and ethylene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.

In the finding the natural ingredient from the botanical plants which process a significant antioxidant activity without inducing any side effects, researchers at the Second Military Medical University looked into a bioactive compound isolated from the herbal Butterbur.

Four novel bakkenolides - bakkenolide-Ia ( 1), bakkenolide-IIa ( 2), bakkenolide-IIIa ( 3) and bakkenolide-IVa ( 4) - were isolated from the extract of the rhizome of Petasites tricholobus.



All 4 compounds demonstrated the neuroprotective activity by reversing the neuron's damage exposed to oxygen-glucose deprivation and oxidative insults.


The results of this efficacy were associated with the antioxidant properties of the 4 compounds in inhibiting the oxidative stress caused by the oxygen-glucose deprivation.


The finding indicated that herbal Butterbur not only processed a significant activity in protecting the brain cells against oxidative stress due to overexpression of free radical but also promoted the production of antioxidant enzymes in the host tissue.

In hyphenated HPLC techniques used to identify the structures and antioxidant activities without prior purification of compounds, researchers found that herbal Butterbur process a number of bioactive compounds, including 5-caffeoylquinic acid (5-CQA), fukinolic acid (FA), 3,5-di-O-caffeoylquinic acid (3,5-DCQA) exert a strong antioxidant free radical scavenging activity.

The greatest radical scavenging capacity was found in the leaf (23.09% of total antioxidant capacity) and root (26.47%) extracts.

The relative radical scavenging portion of quercetin-3-O-(6″-acetyl)-β-glucopyranoside (QAG) was only 3.41% in the leaves and KAG did not show any radical scavenging activity.

These results firmly suggested that herbal Butterbur processes a significant antioxidant property. However, a single ingredient isolated from the herb may express different levels of antioxidants in a dose-depending manner.


Therefore, herbal Butterbur containing a high amount of antioxidants and bioactive compounds free radical scavengers may be considered a functional food for the promotion of the antioxidant activity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities by Wang YL, Li RP, Guo ML, Zhang G, Zhang N, Ma YL.(PubMed)
(2) Free radicals, antioxidants and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)

Healthy Food Cranberry, the Natural Antioxidant

Free radicals are unstable molecules with unpaired electrons in the outermost ring produced daily internally including cell metabolism and externally including the air we breathe and the food we eat.

Reactive oxygen species and reactive nitrogen without being controlled by antioxidant can induce a domino's effect by stealing an electron from other molecules, leading to a continued reaction that cannot stop until all single electrons are paired or inhibited by the presence of antioxidant molecules.


Antioxidants are stable atoms produced either by the host body or intake of dietary antioxidant-rich food.

In this cascade, free radicals overexpression induces oxidative stress. A major cause of protein, lipid and cell damage increase risk of the early onset of many chronic diseases.


In other words, oxidative stress is an imbalanced ratio of free radicals and antioxidants.

Most common diseases or syndromes associated with the onset of oxidative stress are
* Aging, is a process characterized by the progressive loss of tissue and organ function due to the accumulation of RONS-induced damages.

* Cardiovascular diseases (CVD) are diseases associated with involving the heart or blood vessels, including heart disease, and stroke.

* Chronic obstructive pulmonary disease (COPD) is a class of lung disease including chronic bronchitis and emphysema. Most cases of COPD are caused by smoking.

* Chronic kidney disease is a medical condition that causes the gradual loss of kidney function kidney affecting filter wastes and excess fluids from the blood.

* Neurodegenerative diseases is the progressive loss of structure or function of neurons, including dementia.
* Cancer is the class of diseases caused by irregular cell growth due to the alternation of cell DNA

There are many risk factors that can increase the overexpression of free radicals, including fried foods, alcohol, tobacco smoke, pesticides, air pollutants.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of disease associated with oxidative stress, researchers examined the effect of cranberry products and especially cranberry juice (CJ) antioxidant activity.


According to the tested analysis on the products, the order of the number of total polyphenols that exert antioxidant activity in cranberry foods on a fresh weight basis is dried > frozen > sauce > jellied sauce.in the deceased order.

Furthermore, in the comparison of the effect of the consumption of high fructose corn syrup (HFCS) and ascorbate with CJ antioxidants or without CJ (control) given to 10 normal individuals after an overnight fast, by recording the plasma antioxidant capacity, glucose, triglycerides, and ascorbate measured 6 times over 7 h after the consumption of a single 240 mL serving of the two different beverages, researchers found that* HFCS caused a slight decrease in plasma antioxidant capacity at all time points and thus inducing oxidative stress with or without ascorbate

*CJ produced an increase in plasma antioxidant capacity at all time points, particularly compared to
HFCS.

Furthermore, postprandial triglycerides induced oxidative stress caused by HFCS were associated with the oxidative stress in HFCS treated group.

Based on the findings, researchers said, " Cranberries are an excellent source of high-quality antioxidants and should be examined in human supplementation studies".

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antioxidant and antimicrobial properties of bioactive phytochemicals from cranberry by Baranowska M1, Bartoszek A. (PubMed)
(2) Cranberries and cranberry products: powerful in vitro, ex vivo, and in vivo sources of antioxidants by Vinson JA1, Bose P, Proch J, Al Kharrat H, Samman N. (PubMed)

Fennel, A Potent Functional Food for Treatment of Infantile Colic

Fennel may have a profound and positive effect on the reduced risk of infantile colic, some scientists suggest.

Infantile colic is a reaction of the infant if episodes of crying for more than three hours a day, for more than three days a week, for three weeks in an otherwise healthy child. The condition has a strong impacted on psychological, emotional, and physical burden to parents.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)

In a randomized, double-blind, placebo-controlled trial to investigate the effectiveness and side effects of phytotherapeutic agent with Matricariae recutita, Foeniculum vulgare and Melissa officinalis in treatment of infantile colic in a total of the 93 breastfed colicky infants conducted by the John Wiley & Sons, Ltd, after a 3 day observation period, the infants randomly assigned to groups treated with phytotherapeutic agent (PA) and group received placebo twice a day for 1 week, researchers found that crying time in group received PA was reduced substantially in 85.4% of subjects in compared to 48.9% subjects in placebo group against baseline.

PA treatment group exerted no side effects during the period of the experiment.

Base on the result, researchers suggested that PA demonstrated a significant activity within one week of application in infantile colic.


Furthermore, the St. Petersburg Medical Academy of Postdoctoral Education in the concerns of the side effects of 5% of infants treated with dicyclomine hydrochloride, the only pharmacological treatment for infantile colic, with substantial side effects, including death, conducted a randomized placebo-controlled trial of 125 infants, 2 to 12 weeks of age from 2 large multi-specialty clinics by assigning them to either group treated with fennel or placebo, indicated that fennel treatment group improves the crying time episodes and frequency significantly in compared to the placebo group.


According to the Wessel assay, infantile colic was reduced by 65% (40/62) in the treatment group in comparison to only 23.7% (14/59) in placebo.


Further analysis also found that the application of fennel induced a risk reduction of 41% in comparison to placebo without causing any side effects.


Although the causes of infantile colic are unknown, some researchers suggested that the results of fennel in treatment of infantile colic may be attributed to its efficacy in the hypothetical conditions catalyzed by
*Abnormal gastrointestinal function caused by imbalanced of the bacterial ratio

According to the literature reported by the Swansea University, the application of fennel essential oil has a sustainable effect in inhibited E. coli growth, observed by disc diffusion assays and in liquid culture.

These results were illustrated by the effect of an aqueous extract of the aerial part and aqueous extract of seed samples of fennel.

Fennel inhibited the overgrowth of Agrobacterium radiobacter pv. tumefaciens, Erwinia carotovora, Pseudomonas fluorescens, andPseudomonas glycinea, Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Pseudomona aeruginosa, Salmonella typhi, Salmonella typhimurium, Shigella flexneri, and Bacillus cereus in maintenance integrity of digestive function.

Further differentiation also suggested that fennel has a strong impact in protected the gastric damage through significantly increased nitrite, nitrate, ascorbic acid, retinol, and beta-carotene levels.


Dr. Shamkant B. Badgujar, the lead author, in the differentiation of fennel, in regard to the gastrointestinal effect, said, "Foeniculum vulgare is indicated in the treatment of spastic gastrointestinal disturbances, in some forms of chronic colitis (which resist other treatments), in dyspepsias from gastrointestinal atony, in dyspepsias with the sensation of heaviness in the stomach, and so forth. The addition of fennel to preparations containing anthraquinone components reduces the occurrence of abdominal pain often associated with this type of laxative"


* In Psychological aspect of mother such as mother’s depression, anxiety and distress during pregnancy in induction of infantile colic, although there are no direct literature to confirm the efficacy of fennel in treating syndromes of these group of women, but in the study of psychological symptoms in women with premenstrual syndrome, application of fennel seed was associated in decreased depression and anxiety.

Also, in stress-induced maternal anxiety and depression, application of fennel extract (50, 100 and 200 mg/kg body weight) showed a significant improvement of urinary levels of vanillyl mandelic acid(VMA) and ascorbic acid excretion levels in measurement of potentially psychological stress in fennel treatment group in compared to the normal group.

These results indicated that the extract of the entire plant of F. Vulgare pay have a potential effect by acting as an anti-stress agent in reduced depression and anxiety in maternity.


* In food allergic aspect, although there are no direct study in expression of fennel improved immune response against food allergy,.

Some researchers postulated that anethole, a bioactive compound from fennel inhibited food allergy probably through enhancing immune system food hypersensitivity response by modulating the expression of Foxp3+ in regulated the development and function T cells and inhibition of Th2 cytokines in promoted antibodies production of immunoglobulin E (IgE), thus reducing immune system overreacts to an allergen.

Taken together, the findings suggested that fennel may be considered as a function food for treatment of infantile colic, however, a large sample size and study by multi centers are necessary to reconfirm the viability.


Reprint of this article is welcome with name of the author and link back to sources intact https://kylejnorton.blogspot.ca/2018/02/herbal-therapy-fennel-potent-functional.html

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare and Melissa officinalis (ColiMil) in the treatment of breastfed colicky infants by Savino F1, Cresi F, Castagno E, Silvestro L, Oggero R.(PubMed)
(2) The effect of fennel (Foeniculum Vulgare) seed oil emulsion in infantile colic: a randomized, placebo-controlled study by Alexandrovich I1, Rakovitskaya O, Kolmo E, Sidorova T, Shushunov S.(PubMed)
(3) Illicium verum Extract and Trans-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3+ Regulatory T Cells and Inhibition of Th2 Cytokines in Mice by Yoon-Young Sung,1 Seung-Hyung Kim,2 Dong-Seon Kim,3 Ji-eun Lee,2 and Ho Kyoung Kim1(Hidawi)
(4) Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome by Thompson A1, Meah D, Ahmed N, Conniff-Jenkins R, Chileshe E, Phillips CO, Claypole TC, Forman DW, Row PE.(PubMed)
(5) Comparing the Effects of Echinophora-platyloba, Fennel and Placebo on Pre-menstrual Syndrome by Masoumeh Delaram,1,* Soleiman Kheiri,2 and Mohammad Reza Hodjati(PMC)

Wednesday, February 5, 2020

Herbal Chamomile and Hepoprotective effect

Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.

Ingredients
Guaianolides matricarin and achillin, acetoxyachillin and leucodin (= desacetoxymatricarin), corresponding C-11 stereoisomers(a),(Z)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (cis-GMCA), chlorogenic acid, (E)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (trans-GMCA), quercetagetin-7-O-β-d-glucopyranoside, luteolin-7-O-β-d-glucoside, apigenin-7-O-β-d-glucoside, chamaemeloside, apigenin 7-O-(6″-O-acetyl-β-d-glucopyranoside), apigenin] and one polyacetylene (tonghaosu)(b).


Chamomilla Recutita flavonoids (chamiloflan) showed to exhibit antioxidant and anti-inflammatory effects through the induced decrease of ceramide levels in the liver of old rats, according to the Kharkov Karazin National University(1). Flavonoids of German chamomile also exhibited the hepatoprotective effect, through affect sphingolipid metabolism and reduced the elevated ceramide level in the aged liver by normalized activities of key enzymes of sphingolipid turnover (neutral SMase and ceramidase) and ceramide contents in the damaged liver and liver cells, and stabilized the hepatocyte membranes. (2)


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References
(a) Guaianolides and volatile compounds in chamomile tea by Tschiggerl C1, Bucar F.(PubMed)
(b) Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads by Avula B1, Wang YH, Wang M, Avonto C, Zhao J, Smillie TJ, Rua D, Khan IA.(PubMed)
(1a) Anxiety disorder(Canadian mental health association)
References
(1) Effects of Chamomilla recutita flavonoids on age-related liver sphingolipid turnover in rats.
Babenko NA1, Shakhova EG.(PubMed)
(2) Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells by Babenko NA1, Shakhova EG.(PubMed)

Herbal Ashwagandha Protects the Beta Cells of Pancreas Against the Onset of Diabetes in Vivo

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream. Insulin resistance and hyperglycemia are hallmarks of diabetes.

In other words, insulin produced by the pancreas is either blocked by the clogging-up of the insulin receptors by fat and cholesterol or the death of beta cells in the pancreas. In some cases, diabetes can also be associated with autoimmune disease, attacking the beta cells.

There are some major types of diabetes, including the best known, type 1 and 2.
* Type 1 diabetes is associated with a genetic proposition that leads to the immune system to attack insulin-producing cells of the pancreas.

* Type 2 diabetes (acquired diabetes), is a condition caused by either the pancreas doesn't produce enough insulin, or the insulin does not work properly due to dysfunction of the insulin receptors.

In pregnancy, gestational diabetes is a type of diabetes occurred during the second or third trimester of pregnancy. Gestation diabetes goes away after giving birth.

However, omen with gestation diabetes is associated with a substantial risk of diabetic developing sometimes in the future.

Epidemiologically, obesity, an unhealthy lifestyle with physical inactivity are some of the most common risk factor associated with the slow onset of diabetes.

Interestingly, some researchers suggested, night shifts workers accompanied by unhealthy lifestyles are linking to a high risk of type 2 diabetes suggested, " risk of type 2 diabetes is actually higher than simply adding the individual risks associated with unhealthy lifestyle and shift work together, indicating that combining an unhealthy lifestyle with irregular night-time working adds a further risk".

"It is well-established that unhealthy lifestyle behaviors such as smoking, a poor diet, and little exercise, and being overweight or obese increase the risk of type 2 diabetes. Shift work, especially night shift work, has also been associated with a greater risk of type 2 diabetes".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

With an aim to find a potent compound for the treatment of diabetes, researchers examined the effects of Withania somnifera (WS) on lipid peroxidation (LPO) and pancreas in type 2 diabetic rats.

The study included type 2 diabetes induced by a single intraperitoneal injection of STZ (100 mg/kg) to 2 days old rat pups pretreated by WS.


According to the tested analysis, untreated rats group showed significant levels of lipid peroxidation (LPO) observed by reducing levels of antioxidant enzymes produced by the host including glutathione (GSH) contents and by enzymatic activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT).

However, injection of WS not only caused a significant decrease in blood glucose and tissue LPO levels caused by the application of STZ but also a significant increase in GSH contents, compared to type 2 diabetic control rats.

Furthermore, antioxidant enzymes reduced in the untreated rat such as GPx, GR, GST, SOD, and CAT were also increased compared to type 2 diabetic control rats.

Most importantly, the significant reduction in the number and size of pancreatic beta-cells in STZ rats was normalized upon the administration of WS, evident from the histopathological examination.

In other words, WS protects the cells in the pancreas against oxidation and maintains the integrity of beta cells in insulin production in type 2 diabetes rats.

Based on the findings, researchers said, "WS has shown strong free radical scavenging activity and helped in improving the non-enzymatic and enzymatic antioxidants in type 2 diabetic rats".

Taken altogether, Ashwagandha WS may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of type 2 diabetes, pending to the results of large example size and multicenter study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effect of Withania somnifera against oxidative stress and pancreatic beta-cell damage in type 2 diabetic rats by Anwer T1, Sharma M, Pillai KK, Khan G. (PubMed)
(2) Oral supplementation of standardized extract of Withania somnifera protects against diabetes-induced testicular oxidative impairments in prepubertal rats by Kyathanahalli CN1, Manjunath MJ, Muralidhara. (PubMed)
(3) Night shifts and an unhealthy lifestyle linked to high risk of type 2 diabetes by BMJ