Free radicals are unstable molecules with unpaired electrons in the outermost ring produced daily internally including cell metabolism and externally including the air we breathe and the food we eat.
Reactive oxygen species and reactive nitrogen without being controlled by antioxidant can induce a domino's effect by stealing an electron from other molecules, leading to a continued reaction that cannot stop until all single electrons are paired or inhibited by the presence of antioxidant molecules.
Antioxidants are stable atoms produced either by the host body or intake of dietary antioxidant-rich food.
In this cascade, free radicals overexpression induces oxidative stress. A major cause of protein, lipid and cell damage increase risk of the early onset of many chronic diseases.
In other words, oxidative stress is an imbalanced ratio of free radicals and antioxidants.
Most common diseases or syndromes associated with the onset of oxidative stress are
* Aging, is a process characterized by the progressive loss of tissue and organ function due to the accumulation of RONS-induced damages.
* Cardiovascular diseases (CVD) are diseases associated with involving the heart or blood vessels, including heart disease, and stroke.
* Chronic obstructive pulmonary disease (COPD) is a class of lung disease including chronic bronchitis and emphysema. Most cases of COPD are caused by smoking.
* Chronic kidney disease is a medical condition that causes the gradual loss of kidney function kidney affecting filter wastes and excess fluids from the blood.
* Neurodegenerative diseases is the progressive loss of structure or function of neurons, including dementia.
* Cancer is the class of diseases caused by irregular cell growth due to the alternation of cell DNA
There are many risk factors that can increase the overexpression of free radicals, including fried foods, alcohol, tobacco smoke, pesticides, air pollutants.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of disease associated with oxidative stress, researchers examined the effect of cranberry products and especially cranberry juice (CJ) antioxidant activity.
According to the tested analysis on the products, the order of the number of total polyphenols that exert antioxidant activity in cranberry foods on a fresh weight basis is dried > frozen > sauce > jellied sauce.in the deceased order.
Furthermore, in the comparison of the effect of the consumption of high fructose corn syrup (HFCS) and ascorbate with CJ antioxidants or without CJ (control) given to 10 normal individuals after an overnight fast, by recording the plasma antioxidant capacity, glucose, triglycerides, and ascorbate measured 6 times over 7 h after the consumption of a single 240 mL serving of the two different beverages, researchers found that* HFCS caused a slight decrease in plasma antioxidant capacity at all time points and thus inducing oxidative stress with or without ascorbate
*CJ produced an increase in plasma antioxidant capacity at all time points, particularly compared to
HFCS.
Furthermore, postprandial triglycerides induced oxidative stress caused by HFCS were associated with the oxidative stress in HFCS treated group.
Based on the findings, researchers said, " Cranberries are an excellent source of high-quality antioxidants and should be examined in human supplementation studies".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant and antimicrobial properties of bioactive phytochemicals from cranberry by Baranowska M1, Bartoszek A. (PubMed)
(2) Cranberries and cranberry products: powerful in vitro, ex vivo, and in vivo sources of antioxidants by Vinson JA1, Bose P, Proch J, Al Kharrat H, Samman N. (PubMed)
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