Inflammation is a natural reaction of the immune system which protects our body against the stimuli of invasive pathogens.
Acute inflammation is a result of the immune white blood cell response to tissue damage or injury by stimulating the production of proinflammatory cytokines during the acute phase of infection.
Some researchers that the immune has evolved over thousands of years to destroy the foreigner pathogens in a specific time within 3 -8 weeks, otherwise, it will adapt to the change, a leading cause of chronic inflammation.
Allergic airway inflammation is an abnormal reaction of the immune system towards unharmfully common and environmental factors, such as pollen grains or dust mites.
Most common diseases associated with allergic airway inflammation are
* Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood.
*Chronic obstructive pulmonary disease (COPD), the third leading cause of death in the US can be classified into
** Emphysema casued by damage to tissues of the air sacs (alveoli) in the lungs is a type of chronic obstructive pulmonary disease (COPD)associated with a long term and progressive condition cause of shortness of breath but depending to the stage of lung function.
** Chronic bronchitis is a chronic inflammation of the lung’s bronchi that causes the increased production of mucus in the lung induced symptoms of difficulty breathing.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of diseases associated with airway inflammation, researchers examined the effect of bromelain effect on reduced inflammation of preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
The study included sensitized female C57BL/6J mice received phosphate-buffered saline (PBS) with intraperitoneal OVA/alum and then challenged them with OVA aerosolization for 10 consecutive days. However, on day 4, daily doses of PBS was administrated to the control group (n = 10) and bromelain (6mg/kg) in PBS to the bromelain (intervention) group (n = 10).
According to the tested analysis, bromelain treatment of AAD mice (bromelain group) exerted a significant anti-inflammatory activity observed by the reduced BAL total leukocytes (P < .05), eosinophils (P < .05), and cellular infiltrates, compared to the control group.
Futhermore, the bromelain treatment group also significantly reduced BAL CD4+ and CD8+ T cells associated with inflammatory progression without affecting cell numbers in the spleen or hilar lymph node.
Levels of pro-inflammatory cytokines such as interleukins IL-4, IL-12, IL-17, as well as IFN-α in the serum of bromelain-treated animals were also reduced compared to control.
More precisely, bromelain inhibited the allergic airway inflammatory disease through modulating the immune responses and inhibiting the expression of a protein associated with pro-inflammation.
Moreover, on mice sensitized with intraperitoneal (i.p.) OVA/alum and challenged with daily OVA aerosols followed by the treatment of either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days.
Bromelain treatment of AAD mice showed a similar effect as the aforementioned study by reducing total BAL leukocytes, eosinophils, CD4+ and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13, compared to saline group.
Based on the findings, some researchers suggested that bromelain may have similar effects in the treatment of human asthma and hypersensitivity disorders.
Taken altogether, bromelain may be considered a remedy for the prevention and treatment of allergic airway disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease by Secor ER Jr1, Carson WF 4th, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS. (PubMed)
Monday, February 17, 2020
Herbal Ashwagandha Modulates the Immune Response
The immunomodulatory effect is a process in which the immune function is modulated to the needs of the body.
The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.
The immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system. People with the underactive immune system are susceptible to infection, recurrent infections.
* The overactive immune system is also known as autoimmune diseases. In this case, patients suffer diseases associated with the immune system that attacks the body tissues.
In the acute phase of infection, the immune macrophages, the first line of defense stimulates the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.
Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.
The most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.
Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.
However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in the set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.
Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory disease, including diabetes, arthritis, and cardiovascular disease.
Out of many low-grade inflammatory risk factors, some researchers suggested that the promotion of the Western diet over the past few decades may be one of the major culprits involved in facilitating the onset of the diseases.
Dr. Klurfeld DM, the lead scientist wrote, "Diet is a component in the etiology of the two major causes of death in the United States, namely, cardiovascular disease and cancer. During the last decade, various organizations have suggested that we alter the "typical" American diet in order to decrease the incidence of these diseases even though both diseases are indisputable of multiple etiology".
And, "Most Americans can safely reduce their intake of total calories, fat, sugar, and salt. Although this can be achieved most readily on a population basis by following a form of "prudent" diet, it is premature to promise medical benefits to individuals".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for enhancing immune functioning, researchers examined the effects of ashwagandha root extract consumption on the differentially modulated immune response on BALB/c mice.
The study included three selected Withania somnifera chemotypes designated as NMITLI 101R, NMITLI 118R, and NMITLI 128R administered 10-100 mg/kg orally to BALB/c mice once daily for 14 days.
According to the tested assays, all three selected Withania somnifera chemotypes exerted immunomodulatory consequences in the humoral immune response on delayed-type hypersensitivity reaction.
Furthermore, the applications also inhibited the proliferation of T and B cells, intracellular and secreted Th1 and Th2 cytokines along with modulation in ROS production.
Moreover, peritoneal macrophages associated with anti-inflammatory expression was also exhibited by the lower doses (3-30 mg/kg/day) of these three chemotypes injection.
Compared to other chemotypes, the NMITLI 101R has been found to be most effective in the expression of the aforementioned parameters in the immunomodulatory activity.
Based on the findings, researchers said, "it may, therefore, be concluded that there was distinct modulation in the immune response exhibited by the three chemotypes of Withania somnifera and NMITLI 101R appeared to possess a better immunostimulatory activity than the other chemotypes at lower doses.".
Taken altogether, Ashwagandha may be considered an immunomodulatory herb, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemotypical variations in Withania somnifera lead to differentially modulated immune response in BALB/c mice by Kushwaha S1, Roy S, Maity R, Mallick A, Soni VK, Singh PK, Chaurasiya ND, Sangwan RS, Misra-Bhattacharya S, Mandal C. (PubMed)
(2) Withania somnifera chemotype NMITLI 101R significantly increases the efficacy of antileishmanial drugs by generating strong IFN-γ and IL-12 mediated immuneresponses in Leishmania donovani infected hamsters by Tripathi CD1, Kushawaha PK2, Sangwan RS3, Mandal C4, Misra-Bhattacharya S1, Dube A. (PubMed)
The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.
The immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system. People with the underactive immune system are susceptible to infection, recurrent infections.
* The overactive immune system is also known as autoimmune diseases. In this case, patients suffer diseases associated with the immune system that attacks the body tissues.
In the acute phase of infection, the immune macrophages, the first line of defense stimulates the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.
Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.
The most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.
Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.
However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in the set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.
Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory disease, including diabetes, arthritis, and cardiovascular disease.
Out of many low-grade inflammatory risk factors, some researchers suggested that the promotion of the Western diet over the past few decades may be one of the major culprits involved in facilitating the onset of the diseases.
Dr. Klurfeld DM, the lead scientist wrote, "Diet is a component in the etiology of the two major causes of death in the United States, namely, cardiovascular disease and cancer. During the last decade, various organizations have suggested that we alter the "typical" American diet in order to decrease the incidence of these diseases even though both diseases are indisputable of multiple etiology".
And, "Most Americans can safely reduce their intake of total calories, fat, sugar, and salt. Although this can be achieved most readily on a population basis by following a form of "prudent" diet, it is premature to promise medical benefits to individuals".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for enhancing immune functioning, researchers examined the effects of ashwagandha root extract consumption on the differentially modulated immune response on BALB/c mice.
The study included three selected Withania somnifera chemotypes designated as NMITLI 101R, NMITLI 118R, and NMITLI 128R administered 10-100 mg/kg orally to BALB/c mice once daily for 14 days.
According to the tested assays, all three selected Withania somnifera chemotypes exerted immunomodulatory consequences in the humoral immune response on delayed-type hypersensitivity reaction.
Furthermore, the applications also inhibited the proliferation of T and B cells, intracellular and secreted Th1 and Th2 cytokines along with modulation in ROS production.
Moreover, peritoneal macrophages associated with anti-inflammatory expression was also exhibited by the lower doses (3-30 mg/kg/day) of these three chemotypes injection.
Compared to other chemotypes, the NMITLI 101R has been found to be most effective in the expression of the aforementioned parameters in the immunomodulatory activity.
Based on the findings, researchers said, "it may, therefore, be concluded that there was distinct modulation in the immune response exhibited by the three chemotypes of Withania somnifera and NMITLI 101R appeared to possess a better immunostimulatory activity than the other chemotypes at lower doses.".
Taken altogether, Ashwagandha may be considered an immunomodulatory herb, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemotypical variations in Withania somnifera lead to differentially modulated immune response in BALB/c mice by Kushwaha S1, Roy S, Maity R, Mallick A, Soni VK, Singh PK, Chaurasiya ND, Sangwan RS, Misra-Bhattacharya S, Mandal C. (PubMed)
(2) Withania somnifera chemotype NMITLI 101R significantly increases the efficacy of antileishmanial drugs by generating strong IFN-γ and IL-12 mediated immuneresponses in Leishmania donovani infected hamsters by Tripathi CD1, Kushawaha PK2, Sangwan RS3, Mandal C4, Misra-Bhattacharya S1, Dube A. (PubMed)
Sunday, February 16, 2020
In Contrast to General Belief, Bilberry Can Not Improve Night Vision in Healthy Individuals
Vision is a process of detecting light patterns from the outside world and projecting them into images that allow us to see.
Reduced vision is the partial loss of vision, either temporary or permanent.
Night vision is the ability to see in low-light conditions, particularly at the night time
There are some risk factors associated with a reduced night vision, including vitamin A deficiency, people with cataracts, a condition of clouding of the lens in the eye, people with diabetes and eye surgery complications.
Some researchers suggested that people with certain genes inherited from the parent may have better night vision compared to those without.
According to the Scripps Research Institute in the examination of how a particular gene makes night vision possible, published in the August 10, 2011 edition of The Journal of Neuroscience, nyctalopin coordinates the assembly and precise delivery to the synapse of the macromolecular complex consisting of mGluR6, a neurotransmitter receptor protein, which directly communicates with rod photoreceptors and TRPM1, a protein channel that generates the response, making vision possible.
These may be the reason that some people can see better than others in a low light condition
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Searching the list of natural compounds for the treatment of poor night vision, researchers reviewed placebo-controlled trials of V. myrtillus-extracted anthocyanosides for evidence of positive effects on night vision.
According to the standard guidelines and criteria, 30 trials with outcome measures relevant to vision in reduced light were selected for the review.
According to healthy subjects with normal or above-average eyesight tested in 11 of the 12 trials, injection of V. myrtillus anthocyanosides improves normal night vision.
However, due to the lack of rigorous research into the effects of the extract on subjects suffering impaired night vision due to pathological eye conditions, researchers suggested that further trials of V. myrtillus anthocyanosides in subjects with impaired night vision.
In a study included 6 young normal volunteers randomly assigned to one of four different regimens of single oral administrations of 12, 24 and 36 mg of anthocyanosides, and a placebo, with a 2 week washout period between doses.
According to the 3-night vision tests: full-field scotopic retinal threshold (SRT), dark adaptation rate (DAR) and mesopic contrast sensitivity (MCS) conducted by the Assaf Harofeh Medical Center, a single oral administration of 12, 24 or 36 mg anthocyanosides after 24 hours.
These results that single oral administration of 12-36 mg of anthocyanosides does not have a significant effect on militarily relevant night vision tests.
Taken altogether, bilberry although showed a significant improvement of the eyesights caused by visual degeneration and diabetic complication, however, it can not improve night vision in healthy individuals.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanosides of Vaccinium myrtillus (bilberry) for night vision--a systematic review of placebo-controlled trials by Canter PH1, Ernst E. (PubMed)
(2) The effect of anthocyanosides on night vision by Levy Y1, Glovinsky Y. (PubMed)
(3) How a particular gene makes night vision possible by Scripps Research Institute. (Science Daily)
Reduced vision is the partial loss of vision, either temporary or permanent.
Night vision is the ability to see in low-light conditions, particularly at the night time
There are some risk factors associated with a reduced night vision, including vitamin A deficiency, people with cataracts, a condition of clouding of the lens in the eye, people with diabetes and eye surgery complications.
Some researchers suggested that people with certain genes inherited from the parent may have better night vision compared to those without.
According to the Scripps Research Institute in the examination of how a particular gene makes night vision possible, published in the August 10, 2011 edition of The Journal of Neuroscience, nyctalopin coordinates the assembly and precise delivery to the synapse of the macromolecular complex consisting of mGluR6, a neurotransmitter receptor protein, which directly communicates with rod photoreceptors and TRPM1, a protein channel that generates the response, making vision possible.
These may be the reason that some people can see better than others in a low light condition
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Searching the list of natural compounds for the treatment of poor night vision, researchers reviewed placebo-controlled trials of V. myrtillus-extracted anthocyanosides for evidence of positive effects on night vision.
According to the standard guidelines and criteria, 30 trials with outcome measures relevant to vision in reduced light were selected for the review.
According to healthy subjects with normal or above-average eyesight tested in 11 of the 12 trials, injection of V. myrtillus anthocyanosides improves normal night vision.
However, due to the lack of rigorous research into the effects of the extract on subjects suffering impaired night vision due to pathological eye conditions, researchers suggested that further trials of V. myrtillus anthocyanosides in subjects with impaired night vision.
In a study included 6 young normal volunteers randomly assigned to one of four different regimens of single oral administrations of 12, 24 and 36 mg of anthocyanosides, and a placebo, with a 2 week washout period between doses.
According to the 3-night vision tests: full-field scotopic retinal threshold (SRT), dark adaptation rate (DAR) and mesopic contrast sensitivity (MCS) conducted by the Assaf Harofeh Medical Center, a single oral administration of 12, 24 or 36 mg anthocyanosides after 24 hours.
These results that single oral administration of 12-36 mg of anthocyanosides does not have a significant effect on militarily relevant night vision tests.
Taken altogether, bilberry although showed a significant improvement of the eyesights caused by visual degeneration and diabetic complication, however, it can not improve night vision in healthy individuals.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanosides of Vaccinium myrtillus (bilberry) for night vision--a systematic review of placebo-controlled trials by Canter PH1, Ernst E. (PubMed)
(2) The effect of anthocyanosides on night vision by Levy Y1, Glovinsky Y. (PubMed)
(3) How a particular gene makes night vision possible by Scripps Research Institute. (Science Daily)
Herbal Ashwagandha Balance the Ratio of Antioxidants and Free Radicals Against the Onset of Oxidative Stress
Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.
In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.
Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.
However, in people with a weakened immune system, intake dietary sources of antioxidants may be necessary.
Oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.
In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.
Dr. Ercal N, the lead author in the study of the relation of toxic metals and oxidative stress, wrote, "antioxidants may play an important role in abating some hazards of heavy metals. In order to prove the importance of using antioxidants in heavy metal poisoning, pertinent biochemical mechanisms for metal-induced oxidative stress".
There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.
Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.
Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound that processes the antioxidant activity, researchers examined the acetylcholine esterase (AChE) inhibitory and antioxidant potential of Ashwagandha root extract (ARE
Ashwagandha root extract (ARE) in in-vitro and ex-vivo models showed a strong free radical scavenging effect by preventing protein degradation.
In rat lymphocytes, ARE pre-treatment not only protect the immune cells' integrity against s against H2 O2 -induced oxidative damage including DNA fragmentation and significantly decreased the activities of key antioxidant enzymes such as peroxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase.
Furthermore, the decreased and increased the content of glutathione and malondialdehyde induced by the injection H2O2 have also reversed, indicating by the remedy to suppress hydrogen peroxide-induced oxidative stress.
Collectively, researchers said, "The study provides the scientific basis of pleiotropic functions of Ashwagandha".
Taken altogether, Ashwagandha may be considered a functional herb for the treatment of chronic diseases induced by oxidative stress, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ashwagandha Root Extract Inhibits Acetylcholine Esterase, Protein Modification and Ameliorates H2 O2 -Induced Oxidative Stress in Rat Lymphocytes by Ajay Pal1 , Kandikattu Hemanth Kumar2 , Bharat Bhushan*1, Vinod Saharan (Pharmacogn J. 2017; 9(3):302-309A Multifaceted Journal in the field of Natural Products)
(2) Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage by Ercal N1, Gurer-Orhan H, Aykin-Burns N.(PubMed)
In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.
Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.
However, in people with a weakened immune system, intake dietary sources of antioxidants may be necessary.
Oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.
In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.
Dr. Ercal N, the lead author in the study of the relation of toxic metals and oxidative stress, wrote, "antioxidants may play an important role in abating some hazards of heavy metals. In order to prove the importance of using antioxidants in heavy metal poisoning, pertinent biochemical mechanisms for metal-induced oxidative stress".
There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.
Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.
Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound that processes the antioxidant activity, researchers examined the acetylcholine esterase (AChE) inhibitory and antioxidant potential of Ashwagandha root extract (ARE
Ashwagandha root extract (ARE) in in-vitro and ex-vivo models showed a strong free radical scavenging effect by preventing protein degradation.
In rat lymphocytes, ARE pre-treatment not only protect the immune cells' integrity against s against H2 O2 -induced oxidative damage including DNA fragmentation and significantly decreased the activities of key antioxidant enzymes such as peroxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase.
Furthermore, the decreased and increased the content of glutathione and malondialdehyde induced by the injection H2O2 have also reversed, indicating by the remedy to suppress hydrogen peroxide-induced oxidative stress.
Collectively, researchers said, "The study provides the scientific basis of pleiotropic functions of Ashwagandha".
Taken altogether, Ashwagandha may be considered a functional herb for the treatment of chronic diseases induced by oxidative stress, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ashwagandha Root Extract Inhibits Acetylcholine Esterase, Protein Modification and Ameliorates H2 O2 -Induced Oxidative Stress in Rat Lymphocytes by Ajay Pal1 , Kandikattu Hemanth Kumar2 , Bharat Bhushan*1, Vinod Saharan (Pharmacogn J. 2017; 9(3):302-309A Multifaceted Journal in the field of Natural Products)
(2) Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage by Ercal N1, Gurer-Orhan H, Aykin-Burns N.(PubMed)
Saturday, February 15, 2020
Herbal Butterbur Protects Our Airway Hyperresponsiveness in Asthma Patients, According to Studies
Herbal Butterbur may have a potential effect in reducing the airway hyperresponsiveness, one of 2 key pathophysiological features of asthma, some scientists found.
Airway hyperresponsiveness is a condition by an abnormal response of the airways to nonspecific stimuli, which results in airway obstruction.
It is also a reflection of an abnormally amplified response of airway nerves and mast cells to exogenous stimuli, as well as an intrinsic abnormality of the airway smooth muscle response.
Some researchers suggested, airway hyperresponsiveness is linked to both inflammation and repair of the airways and is partially reversible with therapy.
In fact, airway hyperresponsiveness can be objectively demonstrated by initiating the 20% fall in the forced expiratory volume in 1 second (FEV1) after inhalation of histamine or methacholine) at a concentration below 8 mg/mL.
Although researchers do not know what causes hyperresponsiveness but they do know certain risk factors such as the sensitivity of airway nerves, mast cells, and smooth muscle by inflammatory mediators, along with loss of epithelial barrier function, reduced production of bronchoprotective factors, an intrinsic abnormality of airway smooth muscle, and structural changes to the airway, all are likely to play a part in the development of airway hyperresponsiveness.
In the understanding, the relationship between symptoms of asthma and airway hyperresponsiveness, researchers at the McGill University conducted a cohort study, including 457 asthmatic children diagnosed at the age of 3 to 4 years, airway hyperresponsiveness (AHR).
At the final report of the experiment, the researcher wrote, " all patients with asthma persisting but not necessarily current symptoms of asthma have increased AHR,, which satisfies a proposed epidemiologic definition of asthma".
Butterbur, found in wet, marshy, damp land, including wetland, Riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
It has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene, and ethylene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
On finding a natural remedy for the treatment of asthma with no side effects, researchers examined the effect of herbal Petasites hybridus (butterbur) extract (Ze 339, PET) in the murine model of allergic airway disease (asthma).
In immunized BALB/c mice, PET showed a strongly inhibited the allergic response. PET inhibited airway hyperresponsiveness (AHR) and eosinophil recruitment into the bronchoalveolar lavage (BAL) fluid upon allergen challenge but had no effect in the saline control mice.
At a concentration of 100 microg, PET revealed less inflammation, eosinophil recruitment and mucus hyperproduction in the lung, through inhibiting the immune response (RANTES (CCL5)) and production of proinflammatory cytokines associated with asthma without affecting the levels of IgE and eotaxin serum, a marker of asthma.
Furthermore, in the assessment of S-isopetasin, an antimuscarinic sesquiterpene of Butterbur as
a bronchodilator in the treatment of chronic obstructive pulmonary disease and asthma exacerbations, researchers showed
S-isopetasin exerted the inhibitory effects similar to that of ipratropium bromide, a reference drug.
The duration of action of S-isopetasin (20 microM), also similar to that of ipratropium bromide (20 microM), was 3 h.
In contrast to ipratropium bromide, which non-selectively acts on muscarinic receptors, S-isopetasin preferentially acts on muscarinic M3 receptors.
Where Acetylcholine muscarinic M3 receptors (CHRM3) of the airway, expressed in the trachea and bronchi involved airway smooth muscle contraction and mucus secretion in asthma patients.
And, Ipratropium bromide, sold under the trade name Atrovent among others, used to open up the medium and large airways in the lungs.
(P(enh)) value is the probability of obtaining an effect at least as extreme as the one in the sample data, assuming the truth of the null hypothesis.
Taken altogether, herbal Butterbur may be considered a functional herb for the prevention and combined with other primary therapy for the treatment of asthma with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation, and airway hyperreactivity in mice by Brattström A, Schapowal A, Maillet I, Schnyder B, Ryffel B, Moser R.(PubMed)
(2) Bronchodilatory effects of S-isopetasin, an antimuscarinic sesquiterpene of Petasites formosanus, on obstructive airwayhyperresponsiveness by Lin LH, Huang TJ, Wang SH, Lin YL, Wu SN, Ko WC.(PubMed)
(3) Airway hyperresponsiveness and symptoms of asthma in a six-year follow-up study of childhood asthma by Gautrin D1, Lapierre JG, Malo JL, Infante-Rivard C.(PubMed)
Airway hyperresponsiveness is a condition by an abnormal response of the airways to nonspecific stimuli, which results in airway obstruction.
It is also a reflection of an abnormally amplified response of airway nerves and mast cells to exogenous stimuli, as well as an intrinsic abnormality of the airway smooth muscle response.
Some researchers suggested, airway hyperresponsiveness is linked to both inflammation and repair of the airways and is partially reversible with therapy.
In fact, airway hyperresponsiveness can be objectively demonstrated by initiating the 20% fall in the forced expiratory volume in 1 second (FEV1) after inhalation of histamine or methacholine) at a concentration below 8 mg/mL.
Although researchers do not know what causes hyperresponsiveness but they do know certain risk factors such as the sensitivity of airway nerves, mast cells, and smooth muscle by inflammatory mediators, along with loss of epithelial barrier function, reduced production of bronchoprotective factors, an intrinsic abnormality of airway smooth muscle, and structural changes to the airway, all are likely to play a part in the development of airway hyperresponsiveness.
In the understanding, the relationship between symptoms of asthma and airway hyperresponsiveness, researchers at the McGill University conducted a cohort study, including 457 asthmatic children diagnosed at the age of 3 to 4 years, airway hyperresponsiveness (AHR).
At the final report of the experiment, the researcher wrote, " all patients with asthma persisting but not necessarily current symptoms of asthma have increased AHR,, which satisfies a proposed epidemiologic definition of asthma".
Butterbur, found in wet, marshy, damp land, including wetland, Riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
It has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene, and ethylene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
On finding a natural remedy for the treatment of asthma with no side effects, researchers examined the effect of herbal Petasites hybridus (butterbur) extract (Ze 339, PET) in the murine model of allergic airway disease (asthma).
In immunized BALB/c mice, PET showed a strongly inhibited the allergic response. PET inhibited airway hyperresponsiveness (AHR) and eosinophil recruitment into the bronchoalveolar lavage (BAL) fluid upon allergen challenge but had no effect in the saline control mice.
At a concentration of 100 microg, PET revealed less inflammation, eosinophil recruitment and mucus hyperproduction in the lung, through inhibiting the immune response (RANTES (CCL5)) and production of proinflammatory cytokines associated with asthma without affecting the levels of IgE and eotaxin serum, a marker of asthma.
Furthermore, in the assessment of S-isopetasin, an antimuscarinic sesquiterpene of Butterbur as
a bronchodilator in the treatment of chronic obstructive pulmonary disease and asthma exacerbations, researchers showed
S-isopetasin exerted the inhibitory effects similar to that of ipratropium bromide, a reference drug.
The duration of action of S-isopetasin (20 microM), also similar to that of ipratropium bromide (20 microM), was 3 h.
In contrast to ipratropium bromide, which non-selectively acts on muscarinic receptors, S-isopetasin preferentially acts on muscarinic M3 receptors.
Where Acetylcholine muscarinic M3 receptors (CHRM3) of the airway, expressed in the trachea and bronchi involved airway smooth muscle contraction and mucus secretion in asthma patients.
And, Ipratropium bromide, sold under the trade name Atrovent among others, used to open up the medium and large airways in the lungs.
(P(enh)) value is the probability of obtaining an effect at least as extreme as the one in the sample data, assuming the truth of the null hypothesis.
Taken altogether, herbal Butterbur may be considered a functional herb for the prevention and combined with other primary therapy for the treatment of asthma with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation, and airway hyperreactivity in mice by Brattström A, Schapowal A, Maillet I, Schnyder B, Ryffel B, Moser R.(PubMed)
(2) Bronchodilatory effects of S-isopetasin, an antimuscarinic sesquiterpene of Petasites formosanus, on obstructive airwayhyperresponsiveness by Lin LH, Huang TJ, Wang SH, Lin YL, Wu SN, Ko WC.(PubMed)
(3) Airway hyperresponsiveness and symptoms of asthma in a six-year follow-up study of childhood asthma by Gautrin D1, Lapierre JG, Malo JL, Infante-Rivard C.(PubMed)
Whole Food Garlic for Reduced Risk and Treatment of Hypertension
Garlic may be used as a chemopreventive and treatment agent against hypertension. In hypertension of 80-90% of patients with excess glucocorticoid level, allicin found in garlic attenuated dexamethasone-induced anorexia and loss of total body weight.
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising the pressure in your heart. If it stays high over time it can damage the body in many ways.
Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as damaging the kidney. If you can control your diet, such as making changes to lifestyle, maintaining ideal weight and diet with low salt, you could do just fine without the drugs.
In adult men and women, participated in the Tehran Lipid and Glucose Study (2006-2008 to 2012-2014), the intake of garlic is associated to reduce the risk of hypertension by up 26%.
In support of the above, a randomized, placebo-controlled, clinical trial conducted on 56 CAD patients, aged 25 - 75 years old also suggested that treatment with garlic-based drugs can be an effective treatment for controlling BP in CAD patients and has no interaction with other drugs that CAD patients take, after 3 months of administration.
Dr. Takashima M the lead author at the Wakunaga Pharmaceutical Co. Ltd said, " aged garlic extract (AGE) is effective in reducing the blood pressure of hypertensive patients,......AGE induced the concentration-dependent vasorelaxation of isolated rat aortic rings that had been precontracted with norepinephrine"
In fact, Traditional Chinese Medicine, Food Therapy, and Hypertension Control, garlic is of the food recommended to be used to facilitate hypertension control. Based on a statistical analysis of antihypertensive foods recommended in 20 books on the application of food therapy for hypertension control.
Taking all together, garlic may be used as preventive and controlling effects for patients with or without high blood pressure. Some researchers insisted that the garlic anti-hypertension effect may result from its anticoagulant property.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats by Dubey H1,2, Singh A1, Patole AM2, Tenpe CR2(PubMed)
(2) Allium vegetable intakes and the incidence of cardiovascular disease, hypertension, chronic kidney disease, and type 2 diabetes in adults: a longitudinal follow-up study by Bahadoran Z1, Mirmiran P, Momenan AA, Azizi F.(PubMed)
(3) Does Garlic Supplementation Control Blood Pressure in Patients with Severe Coronary Artery Disease? A Clinical Trial Study by Mahdavi-Roshan M1, Nasrollahzadeh J1, Mohammad Zadeh A2, Zahedmehr A3.(PubMed)
(4) Traditional Chinese Medicine, Food Therapy, and Hypertension Control: A Narrative Review of Chinese Literature by Zou P1(PubMed)
(5) The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells by Vilaseca M1,2, García-Calderó H1,3, Lafoz E1,2, García-Irigoyen O3,4, Avila MA3,4, Reverter JC5, Bosch J1,2,3,6, Hernández-Gea V1,3, Gracia-Sancho J1,2,3, García-Pagán JC1,2,3(PubMed)
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising the pressure in your heart. If it stays high over time it can damage the body in many ways.
Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as damaging the kidney. If you can control your diet, such as making changes to lifestyle, maintaining ideal weight and diet with low salt, you could do just fine without the drugs.
In adult men and women, participated in the Tehran Lipid and Glucose Study (2006-2008 to 2012-2014), the intake of garlic is associated to reduce the risk of hypertension by up 26%.
In support of the above, a randomized, placebo-controlled, clinical trial conducted on 56 CAD patients, aged 25 - 75 years old also suggested that treatment with garlic-based drugs can be an effective treatment for controlling BP in CAD patients and has no interaction with other drugs that CAD patients take, after 3 months of administration.
Dr. Takashima M the lead author at the Wakunaga Pharmaceutical Co. Ltd said, " aged garlic extract (AGE) is effective in reducing the blood pressure of hypertensive patients,......AGE induced the concentration-dependent vasorelaxation of isolated rat aortic rings that had been precontracted with norepinephrine"
In fact, Traditional Chinese Medicine, Food Therapy, and Hypertension Control, garlic is of the food recommended to be used to facilitate hypertension control. Based on a statistical analysis of antihypertensive foods recommended in 20 books on the application of food therapy for hypertension control.
Taking all together, garlic may be used as preventive and controlling effects for patients with or without high blood pressure. Some researchers insisted that the garlic anti-hypertension effect may result from its anticoagulant property.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats by Dubey H1,2, Singh A1, Patole AM2, Tenpe CR2(PubMed)
(2) Allium vegetable intakes and the incidence of cardiovascular disease, hypertension, chronic kidney disease, and type 2 diabetes in adults: a longitudinal follow-up study by Bahadoran Z1, Mirmiran P, Momenan AA, Azizi F.(PubMed)
(3) Does Garlic Supplementation Control Blood Pressure in Patients with Severe Coronary Artery Disease? A Clinical Trial Study by Mahdavi-Roshan M1, Nasrollahzadeh J1, Mohammad Zadeh A2, Zahedmehr A3.(PubMed)
(4) Traditional Chinese Medicine, Food Therapy, and Hypertension Control: A Narrative Review of Chinese Literature by Zou P1(PubMed)
(5) The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells by Vilaseca M1,2, García-Calderó H1,3, Lafoz E1,2, García-Irigoyen O3,4, Avila MA3,4, Reverter JC5, Bosch J1,2,3,6, Hernández-Gea V1,3, Gracia-Sancho J1,2,3, García-Pagán JC1,2,3(PubMed)
Friday, February 14, 2020
Herbal Artichoke Protects the Blood Vessels Against the Risk of CVD
Vasoprotection is a term characterized by protecting your blood vessel against the onset of heart disease and stroke.
Blood vessel formed part of the vascular or circulation system that transports the oxygen and nutrients blood to the body tissue and removes unnecessary waste products.
The circulation system also plays an essential role in transporting hormones to the body's needs.
The most common cause of abnormal vascular system is the accumulation of plaque on the arterial wall due to the deposit blood cholesterol and other substances such as calcium and cadmium, leading to hardening and narrowing the arteries over time.
Atherosclerosis is a disease associated with plaque that builds up inside the arteries, a major cause of heart disease and stroke.
Vascular disease can be serious. Blood clots can clog vessels and block blood flow to the heart or brain.
Some researchers suggested that widespread vascular disease in the Western world probably is associated with the promotion of the Western diet over the past few decades.
Dr. Rachel P Ogilvie, the lead scientist, in the examination of the Western diet in the risk of vascular disease, wrote, "Peripheral arterial disease (PAD) is a costly source of morbidity and mortality among older persons in the United States. Dietary intake plays a role in the development of atherosclerotic cardiovascular disease".
And, "...greater meat consumption was associated with a higher risk".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researcher on the finding a natural therapeutic with vasoprotective activity investigated investigate the effects of artichoke on iNOS expression in human coronary artery smooth muscle cells (HCASMC).
The study included HCASMC incubated with a cytokine mixture to induce nitric oxide synthases (iNOS) mRNA expression.
Application of an artichoke leaf extract (1-100 µg/mL, 6 h or 24 h) inhibited the levels of iNOS in concentration- and time-dependent manner.
By inhibiting the expression of iNOS, the artichoke leaf extract also reduced pro-inflammatory cytokine activation by iNOS.
Where nitric oxide synthases are a family of enzymes involved in the production of nitric oxide from L-arginine.
And, Nitric oxide (NO) induces an anti-inflammatory effect under normal physiological conditions. However, under abnormal conditions, NO is considered a pro-inflammatory mediator-induced inflammation.
Additional analysis of the extract against NO in the induction of vascular inflammation and intimal hyperplasia, researchers found that the vasoprotection of the extract was attributed to the four well-known artichoke compounds including cynarin, cyanidin, luteolin, and cynaroside.
In other words, artichoke contains both endothelial nitric-oxide synthase (eNOS-exhibition and iNOS-inhibition compounds.
Where eNOS- is a critical regulator of cardiovascular homeostasis.
Furthermore, in order to reveal more information about nitric oxide (NO) produced by endothelial nitric-oxide synthase (eNOS) represents an antithrombotic and anti-atherosclerotic principle in the vasculature, researchers examined the effect of artichoke extract incubated with human umbilical vein endothelial cells (HUVECs),
According to the luciferase reporter gene assay, artichoke leaf extract (ALE) increased the activity of the human eNOS promoter in EA.hy 926 cells, a cell line derived from human umbilical vein endothelial cells (HUVECs).
By comparing the application of different doses used in the experiment, researchers found organic subfraction from ALE was more potent in this respect than the crude extract, whereas an aqueous subfraction of ALE was without effect in EA.hy 926 cells.
Furthermore, injection of ALE and the organic subfraction increased eNOS mRNA expression and eNOS protein expression both in EA.hy 926 cells and HUVECs.
Interestingly, the flavonoids luteolin and cynaroside increased eNOS promoter activity and eNOS mRNA expression, compared to no effect of caffeoylquinic acids cynarin and chlorogenic acid.
In other words, artichoke increased eNOS gene transcription for the protection of cardiovascular profile was also attributed additionally by the lipid-lowering and antioxidant properties.
Taken altogether, artichoke may be considered a functional remedy for the protection of blood vessels against the risk of cardiovascular disease with no side effects, pending to the validation of larger sample size and multicenter human study.
Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells by Xia N1, Pautz A1, Wollscheid U1, Reifenberg G1, Förstermann U1, Li H. (PubMed)
(2) Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells by Li H1, Xia N, Brausch I, Yao Y, Förstermann U. (PubMed)
(3) Dietary intake and peripheral arterial disease incidence in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study by Rachel P Ogilvie, Pamela L Lutsey, Gerardo Heiss Aaron R Folsom, and Lyn M Steffen (Oxford)
Blood vessel formed part of the vascular or circulation system that transports the oxygen and nutrients blood to the body tissue and removes unnecessary waste products.
The circulation system also plays an essential role in transporting hormones to the body's needs.
The most common cause of abnormal vascular system is the accumulation of plaque on the arterial wall due to the deposit blood cholesterol and other substances such as calcium and cadmium, leading to hardening and narrowing the arteries over time.
Atherosclerosis is a disease associated with plaque that builds up inside the arteries, a major cause of heart disease and stroke.
Vascular disease can be serious. Blood clots can clog vessels and block blood flow to the heart or brain.
Some researchers suggested that widespread vascular disease in the Western world probably is associated with the promotion of the Western diet over the past few decades.
Dr. Rachel P Ogilvie, the lead scientist, in the examination of the Western diet in the risk of vascular disease, wrote, "Peripheral arterial disease (PAD) is a costly source of morbidity and mortality among older persons in the United States. Dietary intake plays a role in the development of atherosclerotic cardiovascular disease".
And, "...greater meat consumption was associated with a higher risk".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researcher on the finding a natural therapeutic with vasoprotective activity investigated investigate the effects of artichoke on iNOS expression in human coronary artery smooth muscle cells (HCASMC).
The study included HCASMC incubated with a cytokine mixture to induce nitric oxide synthases (iNOS) mRNA expression.
Application of an artichoke leaf extract (1-100 µg/mL, 6 h or 24 h) inhibited the levels of iNOS in concentration- and time-dependent manner.
By inhibiting the expression of iNOS, the artichoke leaf extract also reduced pro-inflammatory cytokine activation by iNOS.
Where nitric oxide synthases are a family of enzymes involved in the production of nitric oxide from L-arginine.
And, Nitric oxide (NO) induces an anti-inflammatory effect under normal physiological conditions. However, under abnormal conditions, NO is considered a pro-inflammatory mediator-induced inflammation.
Additional analysis of the extract against NO in the induction of vascular inflammation and intimal hyperplasia, researchers found that the vasoprotection of the extract was attributed to the four well-known artichoke compounds including cynarin, cyanidin, luteolin, and cynaroside.
In other words, artichoke contains both endothelial nitric-oxide synthase (eNOS-exhibition and iNOS-inhibition compounds.
Where eNOS- is a critical regulator of cardiovascular homeostasis.
Furthermore, in order to reveal more information about nitric oxide (NO) produced by endothelial nitric-oxide synthase (eNOS) represents an antithrombotic and anti-atherosclerotic principle in the vasculature, researchers examined the effect of artichoke extract incubated with human umbilical vein endothelial cells (HUVECs),
According to the luciferase reporter gene assay, artichoke leaf extract (ALE) increased the activity of the human eNOS promoter in EA.hy 926 cells, a cell line derived from human umbilical vein endothelial cells (HUVECs).
By comparing the application of different doses used in the experiment, researchers found organic subfraction from ALE was more potent in this respect than the crude extract, whereas an aqueous subfraction of ALE was without effect in EA.hy 926 cells.
Furthermore, injection of ALE and the organic subfraction increased eNOS mRNA expression and eNOS protein expression both in EA.hy 926 cells and HUVECs.
Interestingly, the flavonoids luteolin and cynaroside increased eNOS promoter activity and eNOS mRNA expression, compared to no effect of caffeoylquinic acids cynarin and chlorogenic acid.
In other words, artichoke increased eNOS gene transcription for the protection of cardiovascular profile was also attributed additionally by the lipid-lowering and antioxidant properties.
Taken altogether, artichoke may be considered a functional remedy for the protection of blood vessels against the risk of cardiovascular disease with no side effects, pending to the validation of larger sample size and multicenter human study.
Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells by Xia N1, Pautz A1, Wollscheid U1, Reifenberg G1, Förstermann U1, Li H. (PubMed)
(2) Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells by Li H1, Xia N, Brausch I, Yao Y, Förstermann U. (PubMed)
(3) Dietary intake and peripheral arterial disease incidence in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study by Rachel P Ogilvie, Pamela L Lutsey, Gerardo Heiss Aaron R Folsom, and Lyn M Steffen (Oxford)
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