Neuro-toxicity is a condition of brain damage caused by exposure to toxic substances.
The toxic condition was found to reduce the brain function in transmitting and processing signals to other parts of the nervous system.
Symptoms of neurotoxicity are totally depending on the degree of toxicity. Some symptoms may take some time to develop. However, in most cases, symptoms may appear immediately after exposure.
Depending on the area and location of neuron damage, weakness or numbness, loss of memory, vision, headache change of cognitive and behavioral and sexual dysfunction are the most common symptoms found in people with neurotoxicity.
According to the statistics provided by the University of Ibadan, in the United States, for instance, out of 63 million youths under 18 years of age, about 10% have diagnosable neurobehavioural problems with only 20% receiving therapy and the magnitude affected by neurotoxicity is unknown.
The University continued, "The adverse effects of neurotoxicity are among the most feared ill health in humans because they adversely affect the quality of life", and "Undoubtedly, the magnitude and potential severity of neurotoxicity problems make it imperative to invest in resources required to strengthen the basis for preventive intervention, the forerunner of which is the development of biomarkers for neurotoxicity at the individual and population levels".
In other words, out of millions of people who have neurobehavioural problems, researchers do not know how many of them are actually caused by toxicity.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the analysis of natural compounds with neuroprotective effects in patients with diabetes, researchers examined the antioxidants richly present in bilberry fruits' effects on diabetes-related brain dysfunctions.
The study included the differentiation of the expression patterns of αCaMKII in hippocampal neurons from non-diabetic, diabetic and diabetic rats fed with an extract of bilberry fruit.
Where Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) plays a significant role in cognitive processes.
Diabetic rats hippocampal neurons immunoreactive (ir) to αCaMKII were swollen and the lengths of the neuronal fibers were reduced compared to the significantly longer of αCaMKII-positive nerve fibers in diabetic rats fed with bilberry fruit.
Injection of bilberry fruit also induced significant changes in the average larger diameter of αCaMKII-ir hippocampal neurons.
The results suggested that bilberry fruits exerted the neuroprotective effect on hippocampal neurons in diabetes through its antioxidants activity.
Furthermore, in order to find more information about the bilberry effect on the brain, researchers examined it's anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) neuroprotective effect against retinal damage in vitro and in vivo.
In RGC cultures, VMA and all three anthocyanidins protected the brain against SIN-1 (chloride) toxicity, inhibited lipid peroxidation in mouse forebrain homogenates through the antioxidant property and NMDA-induced morphological retinal damage by allowing high levels of calcium ions (Ca2+) to enter the cells.
Moreover, VMA and all three anthocyanidins also protected the retinal damage by increasing the TUNEL-positive cells in the ganglion cell layer.
Dr. Matsunaga N, the lead scientists said, "VMA and its anthocyanidins have neuroprotective effects (exerted at least in part via an anti-oxidation mechanism) in these in vitro and in vivo models of retinal diseases".
Taken altogether, bilberry may be considered a functional food for the prevention and treatment of neurological diseases associated with neurotoxicity, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats by Matysek M1, Mozel S1, Szalak R1, Zacharko-Siembida A1, Obszańska K1, Arciszewski MB. (PubMed)
(2) Bilberry and its main constituents have neuroprotective effects against retinalneuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H.(PubMed)
(3) Environmental Chemicals and Human Neurotoxicity: Magnitude, Prognosis and Markers by Anetor J. I. 1, Anetor G.O. 2, Iyanda AA1 , Adeniyi FAA. (the University of Ibadan)
Wednesday, February 19, 2020
Tuesday, February 18, 2020
Herbal Bilberry, the Natural Inhibition of Cardiometabolic Risk Factors According to Human Studies
On seeking natural therapy with no side effects, scientists may have a whole fruit for the inhibition of cardiometabolic risk factors (CRFs) associated with the onset of cardiovascular disease,, according to studies.
Cardiovascular disease is a class of diseases involving the blood vessels and heart, depending on the location or area that has been affected.
Cardiometabolic risk factors (CRFs) are conditions that cause damage to the heart and blood vessels. Some researchers suggested that cardiometabolic risk factors are a cluster of condition that causes the onset of diabetes, heart disease or stroke.
Cardiometabolic risk factors can be classified by preventable and nonpreventable risks
* Preventable risk factors can be lower by making a change of lifestyle such as following a healthy diet, quitting smoking, losing weight and exercising daily and moderately.
According to epidemiological studies, a healthy lifestyle has been found to reduce risks of metabolic syndrome, a cluster of conditions associated with the cardiometabolic risk, including lower high blood sugar, cholesterol, and pressure.
* Nonpreventable risks are the risk cannot be changed including aging, ethnicity, family history, medical condition,...
Out of a number of risk factors, some researchers suggested that the prevalent obesity may be the major culprit that causes the onset of diabetes and cardiovascular disease in the Western world.
According to the data provided by the Center for Disease Control and Prevention, "Among participants with overweight (52.5% of the sample), 18.6% had none of the 4 CRFs. Among the 47.5% of participants with obesity, 9.6% had none; among participants with morbid obesity, 5.8% had none. Age was strongly associated with CRFs in multivariable analysis".
The results are according to the measurement of elevated blood pressure (systolic ≥130 mm Hg or diastolic >85 mm Hg or ICD-9-CM [International Classification of Diseases, Ninth Revision, Clinical Modification] diagnosis code 401.0–405.9); elevated triglycerides (≥150 mg/dL or ICD-9-CM 272.1); low high-density lipoprotein cholesterol (<40 mg/dL for men or <50 mg/dL for women or ICD-9-CM 272.5); and prediabetes (fasting glucose 100–125 mg/dL or HbA1c 5.7%–6.4% or ICD-9-CM 790.2x).
The results strongly suggested if you are overweight or obese, you are at an increased risk of diabetes and cardiovascular disease compared to those who do not.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find a natural whole food for the inhibition of cardiometabolic risk factors that increase the risk of CVD and diabetes, researchers examined the effect of baseline metabolome on the overall metabolic responses to berry intake.
The study included 80 overweight women who completed the randomized crossover study randomly assigned to consumed dried sea buckthorn berries (SBs), sea buckthorn oil (SBo), sea buckthorn phenolics ethanol extract mixed with maltodextrin (SBe+MD) (1:1), or frozen bilberries.for 30 days.
By comparing the metabolic profile that reflected higher cardiometabolic risk(group B) at baseline, and participants who had a lower-risk profile (group A), researchers showed that bilberries caused beneficial changes in serum lipids and lipoproteins in group B, whereas the opposite was true in group A.
In other words, bilberry exerted a protective effect against people with cardiometabolic risk without causing harm to people with lower risk profiles.
In order to reveal more information about bilberry inhibition of cardiovascular risk factors researchers investigated regular consumption of bilberries effects on CVD risk reduction, such as decreasing low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs) and increasing high-density lipoprotein cholesterol (HDL-C).
The study involved women (n=25) and men (n=11) who consumed 150 g of frozen stored bilberries 3 times a week for 6 weeks.
During the experiment, the consumption of bilberries led to a decrease in total cholesterol, LDL-C, TG, glucose, albumin, γ-glutamyltransferase, and a positive increase in HDL-C (P=.044). In both women and men.
However, in men, additionally, favorable changes were observed in total cholesterol, glucose, albumin, aspartate aminotransferase, γ-glutamyltransferase, and HDL-C.
Dr. the lead scientist said, "the regular intake of bilberries can be important to reduce CVD risk, by decreasing LDL-C/TG and increasing HDL-C".
Taken altogether, bilberry may be considered a functioning remedy for the inhibition of cardiometabolic risk factors and prevention of CVD, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial by Larmo PS1, Kangas AJ, Soininen P, Lehtonen HM, Suomela JP, Yang B, Viikari J, Ala-Korpela M, Kallio HP. (PubMed)
(2) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(3) Cardiometabolic Risk Factors Among 1.3 Million Adults With Overweight or Obesity, but Not Diabetes, in 10 Geographically Diverse Regions of the United States, 2012–2013. ORIGINAL RESEARCH — Volume 14 — March 9, 2017. (CDC)
Cardiovascular disease is a class of diseases involving the blood vessels and heart, depending on the location or area that has been affected.
Cardiometabolic risk factors (CRFs) are conditions that cause damage to the heart and blood vessels. Some researchers suggested that cardiometabolic risk factors are a cluster of condition that causes the onset of diabetes, heart disease or stroke.
Cardiometabolic risk factors can be classified by preventable and nonpreventable risks
* Preventable risk factors can be lower by making a change of lifestyle such as following a healthy diet, quitting smoking, losing weight and exercising daily and moderately.
According to epidemiological studies, a healthy lifestyle has been found to reduce risks of metabolic syndrome, a cluster of conditions associated with the cardiometabolic risk, including lower high blood sugar, cholesterol, and pressure.
* Nonpreventable risks are the risk cannot be changed including aging, ethnicity, family history, medical condition,...
Out of a number of risk factors, some researchers suggested that the prevalent obesity may be the major culprit that causes the onset of diabetes and cardiovascular disease in the Western world.
According to the data provided by the Center for Disease Control and Prevention, "Among participants with overweight (52.5% of the sample), 18.6% had none of the 4 CRFs. Among the 47.5% of participants with obesity, 9.6% had none; among participants with morbid obesity, 5.8% had none. Age was strongly associated with CRFs in multivariable analysis".
The results are according to the measurement of elevated blood pressure (systolic ≥130 mm Hg or diastolic >85 mm Hg or ICD-9-CM [International Classification of Diseases, Ninth Revision, Clinical Modification] diagnosis code 401.0–405.9); elevated triglycerides (≥150 mg/dL or ICD-9-CM 272.1); low high-density lipoprotein cholesterol (<40 mg/dL for men or <50 mg/dL for women or ICD-9-CM 272.5); and prediabetes (fasting glucose 100–125 mg/dL or HbA1c 5.7%–6.4% or ICD-9-CM 790.2x).
The results strongly suggested if you are overweight or obese, you are at an increased risk of diabetes and cardiovascular disease compared to those who do not.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find a natural whole food for the inhibition of cardiometabolic risk factors that increase the risk of CVD and diabetes, researchers examined the effect of baseline metabolome on the overall metabolic responses to berry intake.
The study included 80 overweight women who completed the randomized crossover study randomly assigned to consumed dried sea buckthorn berries (SBs), sea buckthorn oil (SBo), sea buckthorn phenolics ethanol extract mixed with maltodextrin (SBe+MD) (1:1), or frozen bilberries.for 30 days.
By comparing the metabolic profile that reflected higher cardiometabolic risk(group B) at baseline, and participants who had a lower-risk profile (group A), researchers showed that bilberries caused beneficial changes in serum lipids and lipoproteins in group B, whereas the opposite was true in group A.
In other words, bilberry exerted a protective effect against people with cardiometabolic risk without causing harm to people with lower risk profiles.
In order to reveal more information about bilberry inhibition of cardiovascular risk factors researchers investigated regular consumption of bilberries effects on CVD risk reduction, such as decreasing low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs) and increasing high-density lipoprotein cholesterol (HDL-C).
The study involved women (n=25) and men (n=11) who consumed 150 g of frozen stored bilberries 3 times a week for 6 weeks.
During the experiment, the consumption of bilberries led to a decrease in total cholesterol, LDL-C, TG, glucose, albumin, γ-glutamyltransferase, and a positive increase in HDL-C (P=.044). In both women and men.
However, in men, additionally, favorable changes were observed in total cholesterol, glucose, albumin, aspartate aminotransferase, γ-glutamyltransferase, and HDL-C.
Dr. the lead scientist said, "the regular intake of bilberries can be important to reduce CVD risk, by decreasing LDL-C/TG and increasing HDL-C".
Taken altogether, bilberry may be considered a functioning remedy for the inhibition of cardiometabolic risk factors and prevention of CVD, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial by Larmo PS1, Kangas AJ, Soininen P, Lehtonen HM, Suomela JP, Yang B, Viikari J, Ala-Korpela M, Kallio HP. (PubMed)
(2) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(3) Cardiometabolic Risk Factors Among 1.3 Million Adults With Overweight or Obesity, but Not Diabetes, in 10 Geographically Diverse Regions of the United States, 2012–2013. ORIGINAL RESEARCH — Volume 14 — March 9, 2017. (CDC)
Herbal Artichoke Modulates the Glycemic Responses Against Elevated Level of Glucose After A Meal
Glycemic response is a change in blood glucose after consuming carbohydrate-containing food compared to the Glycemic Index (GI) which is a ranking of carbohydrate-containing foods according to their effect on blood glucose levels.
Some researchers suggested that the glycemic response is the change of blood glucose after the intake of a food or meal.
The most healthy individual has normal blood glucose and insulin levels that rise within the range after eating, then return to the fasting levels over a short period of time.
According to the epidemiological studies, by controlling the glycaemic response with the healthy range, the glycaemic response can reduce the risk of type 2 diabetes.
Including additional fiber into a meal or food may have a strong implication in reducing the levels of glucose shortly after intake.
Dr. Jenkins DJ, the lead scientists in the examination of adding fiber into a meal effect in glycemic response wrote, "Addition of purified fiber to carbohydrate test meals has been shown to flatten the glycemic response in both normal and diabetic volunteers, reduce the insulin requirement in patients on the artificial pancreas and in the longer term reduce urinary glucose loss and improve diabetes control".
And, " More recently it has become clear that many aspects of carbohydrate foods (food form, antinutrients, etc.) in addition to fiber may influence the rate of digestion and has led to a classification especially of starchy foods in terms of glycemic index to define the degree to which equicarbohydrate portions of different foods raise the blood glucose".
The results strongly suggested people with abnormal levels of glycemic responses should always add some fiber to their diet to prevent the fluctuation of blood glucose before and after a meal.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutic for the control of postprandial glycemic responses investigated the extracts from Phaseolus vulgaris and Cynara scolymus and their 1:2 combination effect on postprandial glycemia after food intake.
The study included rats given access to regular food and water, regular food, water, and a chocolate-flavored beverage, or infused with a starch bolus.
According to test assays, injection of P. vulgaris extract and the combination produced comparable reductions in intake of regular food and chocolate-flavored beverage.
Furthermore, P. vulgaris and C. scolymus extracts additively contributed to the reduction of the glycemic rise.
The finding suggested that the combination is more favorable over a single extract for the treatment of postprandial glycemic responses.
Dr. the lead scientist after taking into account co and confounders said, " recent clinical use of the combination of P. vulgaris and C. scolymus extracts in the control of appetite, food intake, and postprandial glycemia".
Taken altogether, artichoke combined with kidney bean may be considered a functional formula for the treatment of patients with elevated postprandial glycemic responses with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymusextracts on food intake and glycemia in rats by Loi B1, Fantini N, Colombo G, Gessa GL, Riva A, Bombardelli E, Morazzoni P, Carai MA. (PubMed)
(2) Dietary fiber and the glycemic response by Jenkins DJ, Jenkins AL. (PubMed)
Some researchers suggested that the glycemic response is the change of blood glucose after the intake of a food or meal.
The most healthy individual has normal blood glucose and insulin levels that rise within the range after eating, then return to the fasting levels over a short period of time.
According to the epidemiological studies, by controlling the glycaemic response with the healthy range, the glycaemic response can reduce the risk of type 2 diabetes.
Including additional fiber into a meal or food may have a strong implication in reducing the levels of glucose shortly after intake.
Dr. Jenkins DJ, the lead scientists in the examination of adding fiber into a meal effect in glycemic response wrote, "Addition of purified fiber to carbohydrate test meals has been shown to flatten the glycemic response in both normal and diabetic volunteers, reduce the insulin requirement in patients on the artificial pancreas and in the longer term reduce urinary glucose loss and improve diabetes control".
And, " More recently it has become clear that many aspects of carbohydrate foods (food form, antinutrients, etc.) in addition to fiber may influence the rate of digestion and has led to a classification especially of starchy foods in terms of glycemic index to define the degree to which equicarbohydrate portions of different foods raise the blood glucose".
The results strongly suggested people with abnormal levels of glycemic responses should always add some fiber to their diet to prevent the fluctuation of blood glucose before and after a meal.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutic for the control of postprandial glycemic responses investigated the extracts from Phaseolus vulgaris and Cynara scolymus and their 1:2 combination effect on postprandial glycemia after food intake.
The study included rats given access to regular food and water, regular food, water, and a chocolate-flavored beverage, or infused with a starch bolus.
According to test assays, injection of P. vulgaris extract and the combination produced comparable reductions in intake of regular food and chocolate-flavored beverage.
Furthermore, P. vulgaris and C. scolymus extracts additively contributed to the reduction of the glycemic rise.
The finding suggested that the combination is more favorable over a single extract for the treatment of postprandial glycemic responses.
Dr. the lead scientist after taking into account co and confounders said, " recent clinical use of the combination of P. vulgaris and C. scolymus extracts in the control of appetite, food intake, and postprandial glycemia".
Taken altogether, artichoke combined with kidney bean may be considered a functional formula for the treatment of patients with elevated postprandial glycemic responses with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymusextracts on food intake and glycemia in rats by Loi B1, Fantini N, Colombo G, Gessa GL, Riva A, Bombardelli E, Morazzoni P, Carai MA. (PubMed)
(2) Dietary fiber and the glycemic response by Jenkins DJ, Jenkins AL. (PubMed)
Monday, February 17, 2020
Bromelain Modulates the Immune Function Against Allergic Airway Disease
Inflammation is a natural reaction of the immune system which protects our body against the stimuli of invasive pathogens.
Acute inflammation is a result of the immune white blood cell response to tissue damage or injury by stimulating the production of proinflammatory cytokines during the acute phase of infection.
Some researchers that the immune has evolved over thousands of years to destroy the foreigner pathogens in a specific time within 3 -8 weeks, otherwise, it will adapt to the change, a leading cause of chronic inflammation.
Allergic airway inflammation is an abnormal reaction of the immune system towards unharmfully common and environmental factors, such as pollen grains or dust mites.
Most common diseases associated with allergic airway inflammation are
* Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood.
*Chronic obstructive pulmonary disease (COPD), the third leading cause of death in the US can be classified into
** Emphysema casued by damage to tissues of the air sacs (alveoli) in the lungs is a type of chronic obstructive pulmonary disease (COPD)associated with a long term and progressive condition cause of shortness of breath but depending to the stage of lung function.
** Chronic bronchitis is a chronic inflammation of the lung’s bronchi that causes the increased production of mucus in the lung induced symptoms of difficulty breathing.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of diseases associated with airway inflammation, researchers examined the effect of bromelain effect on reduced inflammation of preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
The study included sensitized female C57BL/6J mice received phosphate-buffered saline (PBS) with intraperitoneal OVA/alum and then challenged them with OVA aerosolization for 10 consecutive days. However, on day 4, daily doses of PBS was administrated to the control group (n = 10) and bromelain (6mg/kg) in PBS to the bromelain (intervention) group (n = 10).
According to the tested analysis, bromelain treatment of AAD mice (bromelain group) exerted a significant anti-inflammatory activity observed by the reduced BAL total leukocytes (P < .05), eosinophils (P < .05), and cellular infiltrates, compared to the control group.
Futhermore, the bromelain treatment group also significantly reduced BAL CD4+ and CD8+ T cells associated with inflammatory progression without affecting cell numbers in the spleen or hilar lymph node.
Levels of pro-inflammatory cytokines such as interleukins IL-4, IL-12, IL-17, as well as IFN-α in the serum of bromelain-treated animals were also reduced compared to control.
More precisely, bromelain inhibited the allergic airway inflammatory disease through modulating the immune responses and inhibiting the expression of a protein associated with pro-inflammation.
Moreover, on mice sensitized with intraperitoneal (i.p.) OVA/alum and challenged with daily OVA aerosols followed by the treatment of either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days.
Bromelain treatment of AAD mice showed a similar effect as the aforementioned study by reducing total BAL leukocytes, eosinophils, CD4+ and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13, compared to saline group.
Based on the findings, some researchers suggested that bromelain may have similar effects in the treatment of human asthma and hypersensitivity disorders.
Taken altogether, bromelain may be considered a remedy for the prevention and treatment of allergic airway disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease by Secor ER Jr1, Carson WF 4th, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS. (PubMed)
Acute inflammation is a result of the immune white blood cell response to tissue damage or injury by stimulating the production of proinflammatory cytokines during the acute phase of infection.
Some researchers that the immune has evolved over thousands of years to destroy the foreigner pathogens in a specific time within 3 -8 weeks, otherwise, it will adapt to the change, a leading cause of chronic inflammation.
Allergic airway inflammation is an abnormal reaction of the immune system towards unharmfully common and environmental factors, such as pollen grains or dust mites.
Most common diseases associated with allergic airway inflammation are
* Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood.
*Chronic obstructive pulmonary disease (COPD), the third leading cause of death in the US can be classified into
** Emphysema casued by damage to tissues of the air sacs (alveoli) in the lungs is a type of chronic obstructive pulmonary disease (COPD)associated with a long term and progressive condition cause of shortness of breath but depending to the stage of lung function.
** Chronic bronchitis is a chronic inflammation of the lung’s bronchi that causes the increased production of mucus in the lung induced symptoms of difficulty breathing.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of diseases associated with airway inflammation, researchers examined the effect of bromelain effect on reduced inflammation of preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
The study included sensitized female C57BL/6J mice received phosphate-buffered saline (PBS) with intraperitoneal OVA/alum and then challenged them with OVA aerosolization for 10 consecutive days. However, on day 4, daily doses of PBS was administrated to the control group (n = 10) and bromelain (6mg/kg) in PBS to the bromelain (intervention) group (n = 10).
According to the tested analysis, bromelain treatment of AAD mice (bromelain group) exerted a significant anti-inflammatory activity observed by the reduced BAL total leukocytes (P < .05), eosinophils (P < .05), and cellular infiltrates, compared to the control group.
Futhermore, the bromelain treatment group also significantly reduced BAL CD4+ and CD8+ T cells associated with inflammatory progression without affecting cell numbers in the spleen or hilar lymph node.
Levels of pro-inflammatory cytokines such as interleukins IL-4, IL-12, IL-17, as well as IFN-α in the serum of bromelain-treated animals were also reduced compared to control.
More precisely, bromelain inhibited the allergic airway inflammatory disease through modulating the immune responses and inhibiting the expression of a protein associated with pro-inflammation.
Moreover, on mice sensitized with intraperitoneal (i.p.) OVA/alum and challenged with daily OVA aerosols followed by the treatment of either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days.
Bromelain treatment of AAD mice showed a similar effect as the aforementioned study by reducing total BAL leukocytes, eosinophils, CD4+ and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13, compared to saline group.
Based on the findings, some researchers suggested that bromelain may have similar effects in the treatment of human asthma and hypersensitivity disorders.
Taken altogether, bromelain may be considered a remedy for the prevention and treatment of allergic airway disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease by Secor ER Jr1, Carson WF 4th, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS. (PubMed)
Herbal Ashwagandha Modulates the Immune Response
The immunomodulatory effect is a process in which the immune function is modulated to the needs of the body.
The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.
The immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system. People with the underactive immune system are susceptible to infection, recurrent infections.
* The overactive immune system is also known as autoimmune diseases. In this case, patients suffer diseases associated with the immune system that attacks the body tissues.
In the acute phase of infection, the immune macrophages, the first line of defense stimulates the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.
Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.
The most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.
Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.
However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in the set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.
Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory disease, including diabetes, arthritis, and cardiovascular disease.
Out of many low-grade inflammatory risk factors, some researchers suggested that the promotion of the Western diet over the past few decades may be one of the major culprits involved in facilitating the onset of the diseases.
Dr. Klurfeld DM, the lead scientist wrote, "Diet is a component in the etiology of the two major causes of death in the United States, namely, cardiovascular disease and cancer. During the last decade, various organizations have suggested that we alter the "typical" American diet in order to decrease the incidence of these diseases even though both diseases are indisputable of multiple etiology".
And, "Most Americans can safely reduce their intake of total calories, fat, sugar, and salt. Although this can be achieved most readily on a population basis by following a form of "prudent" diet, it is premature to promise medical benefits to individuals".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for enhancing immune functioning, researchers examined the effects of ashwagandha root extract consumption on the differentially modulated immune response on BALB/c mice.
The study included three selected Withania somnifera chemotypes designated as NMITLI 101R, NMITLI 118R, and NMITLI 128R administered 10-100 mg/kg orally to BALB/c mice once daily for 14 days.
According to the tested assays, all three selected Withania somnifera chemotypes exerted immunomodulatory consequences in the humoral immune response on delayed-type hypersensitivity reaction.
Furthermore, the applications also inhibited the proliferation of T and B cells, intracellular and secreted Th1 and Th2 cytokines along with modulation in ROS production.
Moreover, peritoneal macrophages associated with anti-inflammatory expression was also exhibited by the lower doses (3-30 mg/kg/day) of these three chemotypes injection.
Compared to other chemotypes, the NMITLI 101R has been found to be most effective in the expression of the aforementioned parameters in the immunomodulatory activity.
Based on the findings, researchers said, "it may, therefore, be concluded that there was distinct modulation in the immune response exhibited by the three chemotypes of Withania somnifera and NMITLI 101R appeared to possess a better immunostimulatory activity than the other chemotypes at lower doses.".
Taken altogether, Ashwagandha may be considered an immunomodulatory herb, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemotypical variations in Withania somnifera lead to differentially modulated immune response in BALB/c mice by Kushwaha S1, Roy S, Maity R, Mallick A, Soni VK, Singh PK, Chaurasiya ND, Sangwan RS, Misra-Bhattacharya S, Mandal C. (PubMed)
(2) Withania somnifera chemotype NMITLI 101R significantly increases the efficacy of antileishmanial drugs by generating strong IFN-γ and IL-12 mediated immuneresponses in Leishmania donovani infected hamsters by Tripathi CD1, Kushawaha PK2, Sangwan RS3, Mandal C4, Misra-Bhattacharya S1, Dube A. (PubMed)
The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.
The immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system. People with the underactive immune system are susceptible to infection, recurrent infections.
* The overactive immune system is also known as autoimmune diseases. In this case, patients suffer diseases associated with the immune system that attacks the body tissues.
In the acute phase of infection, the immune macrophages, the first line of defense stimulates the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.
Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.
The most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.
Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.
However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in the set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.
Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory disease, including diabetes, arthritis, and cardiovascular disease.
Out of many low-grade inflammatory risk factors, some researchers suggested that the promotion of the Western diet over the past few decades may be one of the major culprits involved in facilitating the onset of the diseases.
Dr. Klurfeld DM, the lead scientist wrote, "Diet is a component in the etiology of the two major causes of death in the United States, namely, cardiovascular disease and cancer. During the last decade, various organizations have suggested that we alter the "typical" American diet in order to decrease the incidence of these diseases even though both diseases are indisputable of multiple etiology".
And, "Most Americans can safely reduce their intake of total calories, fat, sugar, and salt. Although this can be achieved most readily on a population basis by following a form of "prudent" diet, it is premature to promise medical benefits to individuals".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for enhancing immune functioning, researchers examined the effects of ashwagandha root extract consumption on the differentially modulated immune response on BALB/c mice.
The study included three selected Withania somnifera chemotypes designated as NMITLI 101R, NMITLI 118R, and NMITLI 128R administered 10-100 mg/kg orally to BALB/c mice once daily for 14 days.
According to the tested assays, all three selected Withania somnifera chemotypes exerted immunomodulatory consequences in the humoral immune response on delayed-type hypersensitivity reaction.
Furthermore, the applications also inhibited the proliferation of T and B cells, intracellular and secreted Th1 and Th2 cytokines along with modulation in ROS production.
Moreover, peritoneal macrophages associated with anti-inflammatory expression was also exhibited by the lower doses (3-30 mg/kg/day) of these three chemotypes injection.
Compared to other chemotypes, the NMITLI 101R has been found to be most effective in the expression of the aforementioned parameters in the immunomodulatory activity.
Based on the findings, researchers said, "it may, therefore, be concluded that there was distinct modulation in the immune response exhibited by the three chemotypes of Withania somnifera and NMITLI 101R appeared to possess a better immunostimulatory activity than the other chemotypes at lower doses.".
Taken altogether, Ashwagandha may be considered an immunomodulatory herb, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemotypical variations in Withania somnifera lead to differentially modulated immune response in BALB/c mice by Kushwaha S1, Roy S, Maity R, Mallick A, Soni VK, Singh PK, Chaurasiya ND, Sangwan RS, Misra-Bhattacharya S, Mandal C. (PubMed)
(2) Withania somnifera chemotype NMITLI 101R significantly increases the efficacy of antileishmanial drugs by generating strong IFN-γ and IL-12 mediated immuneresponses in Leishmania donovani infected hamsters by Tripathi CD1, Kushawaha PK2, Sangwan RS3, Mandal C4, Misra-Bhattacharya S1, Dube A. (PubMed)
Sunday, February 16, 2020
In Contrast to General Belief, Bilberry Can Not Improve Night Vision in Healthy Individuals
Vision is a process of detecting light patterns from the outside world and projecting them into images that allow us to see.
Reduced vision is the partial loss of vision, either temporary or permanent.
Night vision is the ability to see in low-light conditions, particularly at the night time
There are some risk factors associated with a reduced night vision, including vitamin A deficiency, people with cataracts, a condition of clouding of the lens in the eye, people with diabetes and eye surgery complications.
Some researchers suggested that people with certain genes inherited from the parent may have better night vision compared to those without.
According to the Scripps Research Institute in the examination of how a particular gene makes night vision possible, published in the August 10, 2011 edition of The Journal of Neuroscience, nyctalopin coordinates the assembly and precise delivery to the synapse of the macromolecular complex consisting of mGluR6, a neurotransmitter receptor protein, which directly communicates with rod photoreceptors and TRPM1, a protein channel that generates the response, making vision possible.
These may be the reason that some people can see better than others in a low light condition
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Searching the list of natural compounds for the treatment of poor night vision, researchers reviewed placebo-controlled trials of V. myrtillus-extracted anthocyanosides for evidence of positive effects on night vision.
According to the standard guidelines and criteria, 30 trials with outcome measures relevant to vision in reduced light were selected for the review.
According to healthy subjects with normal or above-average eyesight tested in 11 of the 12 trials, injection of V. myrtillus anthocyanosides improves normal night vision.
However, due to the lack of rigorous research into the effects of the extract on subjects suffering impaired night vision due to pathological eye conditions, researchers suggested that further trials of V. myrtillus anthocyanosides in subjects with impaired night vision.
In a study included 6 young normal volunteers randomly assigned to one of four different regimens of single oral administrations of 12, 24 and 36 mg of anthocyanosides, and a placebo, with a 2 week washout period between doses.
According to the 3-night vision tests: full-field scotopic retinal threshold (SRT), dark adaptation rate (DAR) and mesopic contrast sensitivity (MCS) conducted by the Assaf Harofeh Medical Center, a single oral administration of 12, 24 or 36 mg anthocyanosides after 24 hours.
These results that single oral administration of 12-36 mg of anthocyanosides does not have a significant effect on militarily relevant night vision tests.
Taken altogether, bilberry although showed a significant improvement of the eyesights caused by visual degeneration and diabetic complication, however, it can not improve night vision in healthy individuals.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanosides of Vaccinium myrtillus (bilberry) for night vision--a systematic review of placebo-controlled trials by Canter PH1, Ernst E. (PubMed)
(2) The effect of anthocyanosides on night vision by Levy Y1, Glovinsky Y. (PubMed)
(3) How a particular gene makes night vision possible by Scripps Research Institute. (Science Daily)
Reduced vision is the partial loss of vision, either temporary or permanent.
Night vision is the ability to see in low-light conditions, particularly at the night time
There are some risk factors associated with a reduced night vision, including vitamin A deficiency, people with cataracts, a condition of clouding of the lens in the eye, people with diabetes and eye surgery complications.
Some researchers suggested that people with certain genes inherited from the parent may have better night vision compared to those without.
According to the Scripps Research Institute in the examination of how a particular gene makes night vision possible, published in the August 10, 2011 edition of The Journal of Neuroscience, nyctalopin coordinates the assembly and precise delivery to the synapse of the macromolecular complex consisting of mGluR6, a neurotransmitter receptor protein, which directly communicates with rod photoreceptors and TRPM1, a protein channel that generates the response, making vision possible.
These may be the reason that some people can see better than others in a low light condition
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Searching the list of natural compounds for the treatment of poor night vision, researchers reviewed placebo-controlled trials of V. myrtillus-extracted anthocyanosides for evidence of positive effects on night vision.
According to the standard guidelines and criteria, 30 trials with outcome measures relevant to vision in reduced light were selected for the review.
According to healthy subjects with normal or above-average eyesight tested in 11 of the 12 trials, injection of V. myrtillus anthocyanosides improves normal night vision.
However, due to the lack of rigorous research into the effects of the extract on subjects suffering impaired night vision due to pathological eye conditions, researchers suggested that further trials of V. myrtillus anthocyanosides in subjects with impaired night vision.
In a study included 6 young normal volunteers randomly assigned to one of four different regimens of single oral administrations of 12, 24 and 36 mg of anthocyanosides, and a placebo, with a 2 week washout period between doses.
According to the 3-night vision tests: full-field scotopic retinal threshold (SRT), dark adaptation rate (DAR) and mesopic contrast sensitivity (MCS) conducted by the Assaf Harofeh Medical Center, a single oral administration of 12, 24 or 36 mg anthocyanosides after 24 hours.
These results that single oral administration of 12-36 mg of anthocyanosides does not have a significant effect on militarily relevant night vision tests.
Taken altogether, bilberry although showed a significant improvement of the eyesights caused by visual degeneration and diabetic complication, however, it can not improve night vision in healthy individuals.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanosides of Vaccinium myrtillus (bilberry) for night vision--a systematic review of placebo-controlled trials by Canter PH1, Ernst E. (PubMed)
(2) The effect of anthocyanosides on night vision by Levy Y1, Glovinsky Y. (PubMed)
(3) How a particular gene makes night vision possible by Scripps Research Institute. (Science Daily)
Herbal Ashwagandha Balance the Ratio of Antioxidants and Free Radicals Against the Onset of Oxidative Stress
Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.
In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.
Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.
However, in people with a weakened immune system, intake dietary sources of antioxidants may be necessary.
Oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.
In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.
Dr. Ercal N, the lead author in the study of the relation of toxic metals and oxidative stress, wrote, "antioxidants may play an important role in abating some hazards of heavy metals. In order to prove the importance of using antioxidants in heavy metal poisoning, pertinent biochemical mechanisms for metal-induced oxidative stress".
There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.
Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.
Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound that processes the antioxidant activity, researchers examined the acetylcholine esterase (AChE) inhibitory and antioxidant potential of Ashwagandha root extract (ARE
Ashwagandha root extract (ARE) in in-vitro and ex-vivo models showed a strong free radical scavenging effect by preventing protein degradation.
In rat lymphocytes, ARE pre-treatment not only protect the immune cells' integrity against s against H2 O2 -induced oxidative damage including DNA fragmentation and significantly decreased the activities of key antioxidant enzymes such as peroxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase.
Furthermore, the decreased and increased the content of glutathione and malondialdehyde induced by the injection H2O2 have also reversed, indicating by the remedy to suppress hydrogen peroxide-induced oxidative stress.
Collectively, researchers said, "The study provides the scientific basis of pleiotropic functions of Ashwagandha".
Taken altogether, Ashwagandha may be considered a functional herb for the treatment of chronic diseases induced by oxidative stress, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ashwagandha Root Extract Inhibits Acetylcholine Esterase, Protein Modification and Ameliorates H2 O2 -Induced Oxidative Stress in Rat Lymphocytes by Ajay Pal1 , Kandikattu Hemanth Kumar2 , Bharat Bhushan*1, Vinod Saharan (Pharmacogn J. 2017; 9(3):302-309A Multifaceted Journal in the field of Natural Products)
(2) Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage by Ercal N1, Gurer-Orhan H, Aykin-Burns N.(PubMed)
In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.
Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.
However, in people with a weakened immune system, intake dietary sources of antioxidants may be necessary.
Oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.
In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.
Dr. Ercal N, the lead author in the study of the relation of toxic metals and oxidative stress, wrote, "antioxidants may play an important role in abating some hazards of heavy metals. In order to prove the importance of using antioxidants in heavy metal poisoning, pertinent biochemical mechanisms for metal-induced oxidative stress".
There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.
Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.
Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound that processes the antioxidant activity, researchers examined the acetylcholine esterase (AChE) inhibitory and antioxidant potential of Ashwagandha root extract (ARE
Ashwagandha root extract (ARE) in in-vitro and ex-vivo models showed a strong free radical scavenging effect by preventing protein degradation.
In rat lymphocytes, ARE pre-treatment not only protect the immune cells' integrity against s against H2 O2 -induced oxidative damage including DNA fragmentation and significantly decreased the activities of key antioxidant enzymes such as peroxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase.
Furthermore, the decreased and increased the content of glutathione and malondialdehyde induced by the injection H2O2 have also reversed, indicating by the remedy to suppress hydrogen peroxide-induced oxidative stress.
Collectively, researchers said, "The study provides the scientific basis of pleiotropic functions of Ashwagandha".
Taken altogether, Ashwagandha may be considered a functional herb for the treatment of chronic diseases induced by oxidative stress, pending to the result of larger sample size and multicenter study
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ashwagandha Root Extract Inhibits Acetylcholine Esterase, Protein Modification and Ameliorates H2 O2 -Induced Oxidative Stress in Rat Lymphocytes by Ajay Pal1 , Kandikattu Hemanth Kumar2 , Bharat Bhushan*1, Vinod Saharan (Pharmacogn J. 2017; 9(3):302-309A Multifaceted Journal in the field of Natural Products)
(2) Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage by Ercal N1, Gurer-Orhan H, Aykin-Burns N.(PubMed)
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