Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
Mastitis is the inflammation of breast tissue, mostly caused by Staphylococcus aureus
The ingredients
Besides the main compound of anthraquinones, other compounds include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
The effects
Nanosilver particles (AAgNPs), a derivative of the chemical constituent of aloin found in Cascara Sagrada may be the potential target used as antibiotics for the treatment of infectious and inflammatory diseases, including mastitis. In the Staphylococcus aureus induced murine mastitis study of a total of 40 female mice were divided into five groups of eight animals each, Nanosilver particles (AAgNPs) is found to be effective (concentration of 21.8) than antibiotic as it exerted the anti-inflammatory activity in reducing white blood cell (poly-morpho nuclear cell) infiltration.Other chemical compound emodin found in the herb, in a study of the same but with lipopolysaccharide (LPS)-induced mastitis also found to significantly reduced infiltration of neutrophilic granulocyte. These results may be given the green light for the chemical compounds of Cascara Sagrada used as a novel treatment strategy for mastitis.
The Side effects
1. Cascara Sagrada can be liver toxic.
2. It may cause Postal hypertension
Cascara sagrada (CS) has been associated with the development of cholestatic hepatitis, complicated by portal hypertension.
3. Fresh cut, dried bark may cause vomiting and diarrhea.
4. It may allergic effect.
5. Etc.
References
(1) Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-κB and MAPKs signal pathways by Li D, Zhang N, Cao Y, Zhang W, Su G, Sun Y, Liu Z, Li F, Liang D, Liu B, Guo M, Fu Y, Zhang X, Yang Z.(PubMed)
(2) Evaluation of therapeutic potential of nanosilver particles synthesised using aloin in experimental murine mastitis model by Chaitanya Kumar TV, Muralidhar Y, Prasad PE, Prasad TN, Alpha Raj M.(PubMed)
Thursday, March 19, 2020
Chamomile, the Antimicrobial Whole Herb Medicine in Accelerated Wound Healing
Chamomile, exerted its biotic property in accelerated the progression of wound healing by inhibiting Pseudomonas aeruginosa, in vivo.
According to the Shiraz University of Medical Sciences, treatment of 5% C. Nobile ointment extract from chamomile in rat wounds infected induced by P. aeruginosa, was more effective in the expression of antibacterial and wound healing activities in comparison to tetracycline, the antibiotic medicine.
The chamomile noble, in the Pseudomonas aeruginosa biofilm formation isolated from wound infections, also showed a remarkable inhibitory concentration of 6.25-25mg/ml.
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Dr. Kazemian H. the lead researcher at the joint study said, " C. Nobile may play an important role in its antibacterial activity, thus offering an additional strategy in the fight against bacterial infections. and "However, the molecular investigation is required to explore the exact mechanisms of the antibacterial action and functions of this phytocompound".
Furthermore, in the testing of the effect of chamomile compounds in several models of toxicity (acute toxicity against Artemia salina and cytotoxicity against two cell lines (fibroblast and melanoma)), researchers suggested that these compounds showed low to moderate activity in all tests of acetylcholinesterase inhibitory and antibacterial activities.
And the intake of these compounds in naturally available amounts, on their own, would probably not represent a risk to human health but the possible adverse interactions with the plant matrix should not be neglected.
Therefore, people who intend to use chamomile for reduced risk and treatment of various diseases should be cautious to prevent overdoses' toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) In vivo antibacterial and wound healing activities of Roman chamomile (Chamaemelum nobile) by Kazemian H, Ghafourian S, Sadeghifard N, Badakhsh B, Heidari H1, Taji A, Shavalipour A, Mohebi R, Ebrahim-Saraie HS, Houri H, Houshmandfar R.(PubMed)
(2) Antibacterial, anti-swarming and anti-biofilm formation activities of Chamaemelum nobile against Pseudomonas aeruginosa by Kazemian H1, Ghafourian S1, Heidari H2, Amiri P3, Yamchi JK4, Shavalipour A3, Houri H3, Maleki A1, Sadeghifard N1.(PubMed)
(3) Toxic essential oils. Part III: identification and biological activity of new allylmethoxyphenyl esters from a Chamomile species (Anthemis segetalis Ten.) by Radulović NS1, Mladenović MZ, Blagojević PD, Stojanović-Radić ZZ, Ilic-Tomic T, Senerovic L, Nikodinovic-Runic J.(PubMed)
According to the Shiraz University of Medical Sciences, treatment of 5% C. Nobile ointment extract from chamomile in rat wounds infected induced by P. aeruginosa, was more effective in the expression of antibacterial and wound healing activities in comparison to tetracycline, the antibiotic medicine.
The chamomile noble, in the Pseudomonas aeruginosa biofilm formation isolated from wound infections, also showed a remarkable inhibitory concentration of 6.25-25mg/ml.
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Dr. Kazemian H. the lead researcher at the joint study said, " C. Nobile may play an important role in its antibacterial activity, thus offering an additional strategy in the fight against bacterial infections. and "However, the molecular investigation is required to explore the exact mechanisms of the antibacterial action and functions of this phytocompound".
Furthermore, in the testing of the effect of chamomile compounds in several models of toxicity (acute toxicity against Artemia salina and cytotoxicity against two cell lines (fibroblast and melanoma)), researchers suggested that these compounds showed low to moderate activity in all tests of acetylcholinesterase inhibitory and antibacterial activities.
And the intake of these compounds in naturally available amounts, on their own, would probably not represent a risk to human health but the possible adverse interactions with the plant matrix should not be neglected.
Therefore, people who intend to use chamomile for reduced risk and treatment of various diseases should be cautious to prevent overdoses' toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) In vivo antibacterial and wound healing activities of Roman chamomile (Chamaemelum nobile) by Kazemian H, Ghafourian S, Sadeghifard N, Badakhsh B, Heidari H1, Taji A, Shavalipour A, Mohebi R, Ebrahim-Saraie HS, Houri H, Houshmandfar R.(PubMed)
(2) Antibacterial, anti-swarming and anti-biofilm formation activities of Chamaemelum nobile against Pseudomonas aeruginosa by Kazemian H1, Ghafourian S1, Heidari H2, Amiri P3, Yamchi JK4, Shavalipour A3, Houri H3, Maleki A1, Sadeghifard N1.(PubMed)
(3) Toxic essential oils. Part III: identification and biological activity of new allylmethoxyphenyl esters from a Chamomile species (Anthemis segetalis Ten.) by Radulović NS1, Mladenović MZ, Blagojević PD, Stojanović-Radić ZZ, Ilic-Tomic T, Senerovic L, Nikodinovic-Runic J.(PubMed)
Wednesday, March 18, 2020
Ginger, The Anti Gastrointestinal Disorder Functional Pungent Spice
Scientists may have found a kitchen pungent spice for the treatment of the gastrointestinal disorder, some studies suggested.
Gastrointestinal diseases are the conditions of the digestive system associated with the disorders involving the gastrointestinal tract, including the esophagus, stomach, small intestine, large intestine, and rectum.
The digestive system includes gastrointestinal tract (GI), liver, pancreas, and gallbladder with a healthy function of breaking down food into nutrients and fluids for the body's need.
There are many different types of gastrointestinal diseases, including irritable bowel syndrome (IBS), Crohn's disease, celiac disease, and lactose intolerance.
There are many causes of gastrointestinal disorders, such as bacterial and viral infection, inflammation, poor circulation to the intestines, muscle dysfunction, gallstones, stress, particularly long-term use of anti-inflammatory drugs.
Conventional medicine used for the treatment of gastrointestinal disorders is depending on the disease that triggers the disorder.such as antibiotics for bacterial infection, painkillers for stomach pain.
Sherry Coleman Collins, MS, RDN, LD in the article, Natural Remedies for Digestive Disorders outlined the percentage of the use of natural remedies for the treatment of gastrointestinal disorders, and how much money that the American spend a year in purchasing these remedy.
Believe or not, it is equivalent to about one-third of out-of-pocket dollars spent on prescription drugs.
The dietitian wrote, " more clients and patients are looking for ways to treat their digestive disorders with natural medicines sold over the counter. According to a 2007 National Institutes of Health-funded survey on the use of complementary and alternative medicines in the United States, roughly 38% of adults use natural remedies, such as diet-based therapies (eg, gluten-free diets) and herbs, among others" and
"Also in 2007, it was estimated that nearly $34 billion was spent on complementary and alternative medicines, including about $15 billion on “nonvitamin, nonmineral, natural products:.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The pungent spice has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to reconfirm the traditional use of ginger against various gastric ailments, researchers at the Tehran University of Medical Sciences conducted an experiment to review the ginger effect in the prevention of antituberculosis-induced gastrointestinal adverse reactions.
A randomized pilot clinical trial included 60 patients who were placed into ginger and placebo groups (30 patients in each group) received either 500 mg ginger (Zintoma)(®) or placebo one-half hour before each daily dose of antituberculosis drugs for 4 weeks.
After examining the Patients' gastrointestinal complaints (nausea, vomiting, dyspepsia, and abdominal pain) and antituberculosis drug-induced hepatotoxicity were recorded during the study period, researchers showed that application ginger to the 48 (80%) patients experienced nausea caused by antituberculosis drug-induced gastrointestinal adverse reactions, reduced gastrointestinal disorders by 56% compared to 43% in the placebo.
Patients in the ginger group experienced less, but not statistically significant, antituberculosis drug-induced hepatotoxicity than the placebo group (16.7% vs 36.7%, respectively, p = 0.07).
Dr. Emrani Z, the lead author in the final report wrote, "ginger may be a potential option for prevention of antituberculosis drug-induced gastrointestinal adverse reactions including hepatotoxicity".
Additionally, in the concern of the use of aspirin is its side effect to cause ulceration and bleeding in the gastrointestinal tract, a joint study led by the North Carolina Agricultural and Technical State University was conducted to examine the ginger effect in reducing the risk of gastrointestinal disorder caused by the injection of low dose aspirin.
Injection of ginger exerted a strong activity in the ameliorated ASA-induced gastric ulceration.
[6]-gingerol aspirinate (GAS), the combination of ginger bioactive compounds [6[-gingerol and aspirin demonstrated anti-cancer properties in vitro and superior gastroprotective effects in mice.
The combination (GAS) was also able to survive stomach acid and decomposed in intestinal linings or after absorption to simultaneously release ASA and [6]-gingerol.
GAS inactivates both COX-1 and COX-2 equally to reduce symptoms of inflammation and pain caused by ASA-induced gastric ulceration.
The findings suggested that ginger processes gastroprotective effects and GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa.
Taken altogether, ginger with abundant gingerols may be considered a functional food for the prevention and adjunct therapy for the treatment of gastrointestinal disorder with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). by Haniadka R1, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS. (PubMed)
(2) Ginger for Prevention of Antituberculosis-induced Gastrointestinal Adverse Reactions Including Hepatotoxicity: A Randomized Pilot Clinical Trial by Emrani Z1, Shojaei E2, Khalili H. (PubMed)
(3) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Zhu Y1, Wang F1,2, Zhao Y1, Wang P1, Sang S. (PubMed)
Gastrointestinal diseases are the conditions of the digestive system associated with the disorders involving the gastrointestinal tract, including the esophagus, stomach, small intestine, large intestine, and rectum.
The digestive system includes gastrointestinal tract (GI), liver, pancreas, and gallbladder with a healthy function of breaking down food into nutrients and fluids for the body's need.
There are many different types of gastrointestinal diseases, including irritable bowel syndrome (IBS), Crohn's disease, celiac disease, and lactose intolerance.
There are many causes of gastrointestinal disorders, such as bacterial and viral infection, inflammation, poor circulation to the intestines, muscle dysfunction, gallstones, stress, particularly long-term use of anti-inflammatory drugs.
Conventional medicine used for the treatment of gastrointestinal disorders is depending on the disease that triggers the disorder.such as antibiotics for bacterial infection, painkillers for stomach pain.
Sherry Coleman Collins, MS, RDN, LD in the article, Natural Remedies for Digestive Disorders outlined the percentage of the use of natural remedies for the treatment of gastrointestinal disorders, and how much money that the American spend a year in purchasing these remedy.
Believe or not, it is equivalent to about one-third of out-of-pocket dollars spent on prescription drugs.
The dietitian wrote, " more clients and patients are looking for ways to treat their digestive disorders with natural medicines sold over the counter. According to a 2007 National Institutes of Health-funded survey on the use of complementary and alternative medicines in the United States, roughly 38% of adults use natural remedies, such as diet-based therapies (eg, gluten-free diets) and herbs, among others" and
"Also in 2007, it was estimated that nearly $34 billion was spent on complementary and alternative medicines, including about $15 billion on “nonvitamin, nonmineral, natural products:.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The pungent spice has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to reconfirm the traditional use of ginger against various gastric ailments, researchers at the Tehran University of Medical Sciences conducted an experiment to review the ginger effect in the prevention of antituberculosis-induced gastrointestinal adverse reactions.
A randomized pilot clinical trial included 60 patients who were placed into ginger and placebo groups (30 patients in each group) received either 500 mg ginger (Zintoma)(®) or placebo one-half hour before each daily dose of antituberculosis drugs for 4 weeks.
After examining the Patients' gastrointestinal complaints (nausea, vomiting, dyspepsia, and abdominal pain) and antituberculosis drug-induced hepatotoxicity were recorded during the study period, researchers showed that application ginger to the 48 (80%) patients experienced nausea caused by antituberculosis drug-induced gastrointestinal adverse reactions, reduced gastrointestinal disorders by 56% compared to 43% in the placebo.
Patients in the ginger group experienced less, but not statistically significant, antituberculosis drug-induced hepatotoxicity than the placebo group (16.7% vs 36.7%, respectively, p = 0.07).
Dr. Emrani Z, the lead author in the final report wrote, "ginger may be a potential option for prevention of antituberculosis drug-induced gastrointestinal adverse reactions including hepatotoxicity".
Additionally, in the concern of the use of aspirin is its side effect to cause ulceration and bleeding in the gastrointestinal tract, a joint study led by the North Carolina Agricultural and Technical State University was conducted to examine the ginger effect in reducing the risk of gastrointestinal disorder caused by the injection of low dose aspirin.
Injection of ginger exerted a strong activity in the ameliorated ASA-induced gastric ulceration.
[6]-gingerol aspirinate (GAS), the combination of ginger bioactive compounds [6[-gingerol and aspirin demonstrated anti-cancer properties in vitro and superior gastroprotective effects in mice.
The combination (GAS) was also able to survive stomach acid and decomposed in intestinal linings or after absorption to simultaneously release ASA and [6]-gingerol.
GAS inactivates both COX-1 and COX-2 equally to reduce symptoms of inflammation and pain caused by ASA-induced gastric ulceration.
The findings suggested that ginger processes gastroprotective effects and GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa.
Taken altogether, ginger with abundant gingerols may be considered a functional food for the prevention and adjunct therapy for the treatment of gastrointestinal disorder with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). by Haniadka R1, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS. (PubMed)
(2) Ginger for Prevention of Antituberculosis-induced Gastrointestinal Adverse Reactions Including Hepatotoxicity: A Randomized Pilot Clinical Trial by Emrani Z1, Shojaei E2, Khalili H. (PubMed)
(3) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Zhu Y1, Wang F1,2, Zhao Y1, Wang P1, Sang S. (PubMed)
The Effects of Herbal Dang Gui (Angelica root) on Diabetes
Dang Gui (Angelica root) may be used alone and conjunction with other herbs in reduced blood glucose of patients with diabetes a new study suggested.
According to the 2011 statistic from National Diabetes InformationClearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, had diabetes in 2010, about 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010 and approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.
Besides acting like a queen herb in balancing the hormones in women for a normal menstrual cycle and menstruation, Dang Qui also used in traditional Chinese medicine to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.(1)
Dang Gui Bu Xue Tang (DBT), an aqueous extract of Radix Astragali and Radix Angelica sinensis of Chinese herbal formula, showed to significantly alleviate the hyperglycemia but made no influence on plasma lipid profiles nor weight gain in fructose chow-fed rats when applied alone, through increased post-receptor insulin signaling(2). Together with Panax notoginseng (RRP), the extract showed to reverse high glucose-induced inhibition of endothelial cell migration and proliferation, through decreased the expression of inflammatory factors(3).
Decursin, an active compound isolated from Angelica gigas, also showed a significantly reduced the secretion of HFD-induced adipocytokines such as leptin, resistin, IL-6 and MCP-1 associated with diabetes and obesity(4)
Angelica Keiskei, another member of Angelica improved insulin resistance in diabetes of rats induced by streptozotocin with intraperitoneal injection as well as with high-fat diet feeding through upregulation of the mRNA expression levels of PI3K and Akt(5).
Dr, Zhao Y. and the research team at the Medical College of Qingdao University also in the study of the effect of Angelica Keiskei in diabetes told PubMed " Angelica keiskei chalcone (the extract) may increase the expression levels of Glut2 in liver and Glut4 in skeletal muscle cells, decrease fasting blood glucose and insulin of type 2 diabetic rats and improve their insulin resistance condition"(6).
Unfortunately, oral administration of angelica has linked to the proliferation of breast cancer for women with a history of breast cancer and gene mutation Her-2(7)(8).
Taken altogether, Dang Qui may be effective in reduced glucose levels of patients with type II diabetes and can be considered for the prevention of diabetic complications. Due to its conflict results in breast cancer studies, it is advisable that women with mutation gene Her or with a history of breast cancer should consult their Doctor & Related field specialist before applying. As always, all articles written by Kyle J. Norton are for information & education only,
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Popular #Herbs - #Dang Qui (Angelica sinensis)
(2) A Chinese Herbal Decoction, Dang Gui Bu Xue Tang, Prepared from Radix Astragali and Radix Angelicae sinensis, Ameliorates Insulin Resistance Induced by A High-Fructose Diet in Rats by Liu IM1, Tzeng TF, Liou SS(PubMed)
(3) An Aqueous Extract of Radix Astragali, Angelica sinensis, and Panax notoginseng Is Effective in Preventing Diabetic Retinopathy by Gao D1, Guo Y, Li X, Li X, Li Z, Xue M, Ou Z, Liu M, Yang M, Liu S, Yang S.(PubMed)
(4) [Effect of ashitabe chalcones on the mRNA expression of PI3K and Akt in hepatocytes of rats with diabetes].[Article in Chinese] by Liu B1, Sun J, Zhao Y, Li L, Zhong J.(PubMed)
(5) Decursin, an active compound isolated from Angelica gigas, inhibits fat accumulation, reduces adipocytokine secretion and improves glucose tolerance in mice fed a high-fat diet by Hwang JT1, Kim SH, Hur HJ, Kim HJ, Park JH, Sung MJ, Yang HJ, Ryu SY, Kim YS, Cha MR, Kim MS, Kwon DY.(PubMed)
(6) [Effects of angelica keiskei chalcone on expression of glucose transporter proteins in liver and skeletal muscle cells of type 2 diabetic rats].[Article in Chinese] by Zhao Y1, Liu B, Li L, Zhong J.(PubMed)
(7) Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: is it appropriate? by Lau CB1, Ho TC, Chan TW, Kim SC.(PubMed)
(8) Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells by Chang CJ1, Chiu JH, Tseng LM, Chang CH, Chien TM, Wu CW, Lui WY.(PubMed)
According to the 2011 statistic from National Diabetes InformationClearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, had diabetes in 2010, about 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010 and approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.
Besides acting like a queen herb in balancing the hormones in women for a normal menstrual cycle and menstruation, Dang Qui also used in traditional Chinese medicine to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.(1)
Dang Gui Bu Xue Tang (DBT), an aqueous extract of Radix Astragali and Radix Angelica sinensis of Chinese herbal formula, showed to significantly alleviate the hyperglycemia but made no influence on plasma lipid profiles nor weight gain in fructose chow-fed rats when applied alone, through increased post-receptor insulin signaling(2). Together with Panax notoginseng (RRP), the extract showed to reverse high glucose-induced inhibition of endothelial cell migration and proliferation, through decreased the expression of inflammatory factors(3).
Decursin, an active compound isolated from Angelica gigas, also showed a significantly reduced the secretion of HFD-induced adipocytokines such as leptin, resistin, IL-6 and MCP-1 associated with diabetes and obesity(4)
Angelica Keiskei, another member of Angelica improved insulin resistance in diabetes of rats induced by streptozotocin with intraperitoneal injection as well as with high-fat diet feeding through upregulation of the mRNA expression levels of PI3K and Akt(5).
Dr, Zhao Y. and the research team at the Medical College of Qingdao University also in the study of the effect of Angelica Keiskei in diabetes told PubMed " Angelica keiskei chalcone (the extract) may increase the expression levels of Glut2 in liver and Glut4 in skeletal muscle cells, decrease fasting blood glucose and insulin of type 2 diabetic rats and improve their insulin resistance condition"(6).
Unfortunately, oral administration of angelica has linked to the proliferation of breast cancer for women with a history of breast cancer and gene mutation Her-2(7)(8).
Taken altogether, Dang Qui may be effective in reduced glucose levels of patients with type II diabetes and can be considered for the prevention of diabetic complications. Due to its conflict results in breast cancer studies, it is advisable that women with mutation gene Her or with a history of breast cancer should consult their Doctor & Related field specialist before applying. As always, all articles written by Kyle J. Norton are for information & education only,
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Popular #Herbs - #Dang Qui (Angelica sinensis)
(2) A Chinese Herbal Decoction, Dang Gui Bu Xue Tang, Prepared from Radix Astragali and Radix Angelicae sinensis, Ameliorates Insulin Resistance Induced by A High-Fructose Diet in Rats by Liu IM1, Tzeng TF, Liou SS(PubMed)
(3) An Aqueous Extract of Radix Astragali, Angelica sinensis, and Panax notoginseng Is Effective in Preventing Diabetic Retinopathy by Gao D1, Guo Y, Li X, Li X, Li Z, Xue M, Ou Z, Liu M, Yang M, Liu S, Yang S.(PubMed)
(4) [Effect of ashitabe chalcones on the mRNA expression of PI3K and Akt in hepatocytes of rats with diabetes].[Article in Chinese] by Liu B1, Sun J, Zhao Y, Li L, Zhong J.(PubMed)
(5) Decursin, an active compound isolated from Angelica gigas, inhibits fat accumulation, reduces adipocytokine secretion and improves glucose tolerance in mice fed a high-fat diet by Hwang JT1, Kim SH, Hur HJ, Kim HJ, Park JH, Sung MJ, Yang HJ, Ryu SY, Kim YS, Cha MR, Kim MS, Kwon DY.(PubMed)
(6) [Effects of angelica keiskei chalcone on expression of glucose transporter proteins in liver and skeletal muscle cells of type 2 diabetic rats].[Article in Chinese] by Zhao Y1, Liu B, Li L, Zhong J.(PubMed)
(7) Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: is it appropriate? by Lau CB1, Ho TC, Chan TW, Kim SC.(PubMed)
(8) Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells by Chang CJ1, Chiu JH, Tseng LM, Chang CH, Chien TM, Wu CW, Lui WY.(PubMed)
Tuesday, March 17, 2020
Garlic, The Kitchen Spice in the Prevention and Treatment of Hypertension, Scientists Recommend
Scientists may have found a common kitchen spice with potential in reducing high blood pressure quickly without including any side effects, some studies endorsed.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
High blood pressure means raising the pressure in your heart. If it stays high over time it can damage the body in many ways.
The causes of hypertension are unknown. However, researchers do know that acute hypertension is induced by daily stress.
Certain risk factors such as unhealthy lifestyle choices, physical inactivity unhealthy diet with high in saturated and trans fat, refined products, processed food, high sugar, and salt intake,...... over time cause your blood pressure to spice-up chronically.
Lifestyle choices can also lead to overweight or obese, the risk factors for the early onset of hypertension.
According to the statistic, in the US, over 75 million adults or 32% have high blood pressure.
In other words, 1 in every 3 American adults has the syndrome. Sadly 44% of the mentioned adults with high blood pressure are not under control.
Uncontrol high blood pressure has long been known as a major risk factor for the development of heart disease and stroke, the leading causes of death in the United States.
Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as gastrointestinal discomforts, tiredness, weakness, headache.
Some patients who are taking hypertensive medicine over prolonged periods of time may experience symptoms of erectile dysfunction.
In severe cases, the intake of antihypertensive drugs for the long term can cause dermatitis, arthritis and anemia and lupus erythematosus-like syndrome, according to the article "Adverse Effects of Antihypertensive Drugs" written by Dr. DWARD D. FREIS, M.D.
If you are currently taking any anti-high blood pressure medications, please make you that you know all the side effects.
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia.
The kitchen spice has been used popularly in traditional and Chinese medicine in treating common cold and flu, blood pressure cholesterol levels, natural antibiotics, etc.
In adult men and women, participated in the Tehran Lipid and Glucose Study (2006-2008 to 2012-2014), the intake of garlic is associated to reduce the risk of hypertension by up 26%.
In hypertension of 80-90% of patients with excess glucocorticoid level, allicin found in garlic attenuated dexamethasone-induced anorexia and loss of total body weight.
A randomized, placebo-controlled, clinical trial conducted on 56 CVD patients, aged 25 - 75 years old also suggested treatment with garlic-based drugs can be effective for controlling BP in CVD patients and has no interaction with other drugs that CAD patients take, after 3 months of the administration.
Dr. Takashima M the lead author at the Wakunaga Pharmaceutical Co. Ltd said, " aged garlic extract (AGE) is effective in reducing the blood pressure of hypertensive patients,......AGE-induced the concentration-dependent vasorelaxation of isolated rat aortic rings that had been precontracted with norepinephrine"
In fact, traditional Chinese medicine, food therapy, and hypertension control, all recommended that garlic is of the food to be used for hypertension control, according to a statistical analysis of antihypertensive foods recommended in 20 books on the application of food therapy for hypertension control.
If you can control your diet, make changes to lifestyle, maintaining an ideal weight, you could do just fine without the drugs,
Taking all together, garlic may be used as preventive and controlling effects for patients with or without high blood pressure. Some researchers insisted that garlic anti-hypertension effect may result from its anticoagulant property.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats by Dubey H1,2, Singh A1, Patole AM2, Tenpe CR2(PubMed)
(2) Allium vegetable intakes and the incidence of cardiovascular disease, hypertension, chronic kidney disease, and type 2 diabetes in adults: a longitudinal follow-up study by Bahadoran Z1, Mirmiran P, Momenan AA, Azizi F.(PubMed)
(3) Does Garlic Supplementation Control Blood Pressure in Patients with Severe Coronary Artery Disease? A Clinical Trial Study by Mahdavi-Roshan M1, Nasrollahzadeh J1, Mohammad Zadeh A2, Zahedmehr A3. (PubMed)
(4) Traditional Chinese Medicine, Food Therapy, and Hypertension Control: A Narrative Review of Chinese Literature by Zou P1(PubMed)
(5) The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells by Vilaseca M1,2, García-Calderó H1,3, Lafoz E1,2, García-Irigoyen O3,4, Avila MA3,4, Reverter JC5, Bosch J1,2,3,6, Hernández-Gea V1,3, Gracia-Sancho J1,2,3, García-Pagán JC1,2,3(PubMed)
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
High blood pressure means raising the pressure in your heart. If it stays high over time it can damage the body in many ways.
The causes of hypertension are unknown. However, researchers do know that acute hypertension is induced by daily stress.
Certain risk factors such as unhealthy lifestyle choices, physical inactivity unhealthy diet with high in saturated and trans fat, refined products, processed food, high sugar, and salt intake,...... over time cause your blood pressure to spice-up chronically.
Lifestyle choices can also lead to overweight or obese, the risk factors for the early onset of hypertension.
According to the statistic, in the US, over 75 million adults or 32% have high blood pressure.
In other words, 1 in every 3 American adults has the syndrome. Sadly 44% of the mentioned adults with high blood pressure are not under control.
Uncontrol high blood pressure has long been known as a major risk factor for the development of heart disease and stroke, the leading causes of death in the United States.
Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as gastrointestinal discomforts, tiredness, weakness, headache.
Some patients who are taking hypertensive medicine over prolonged periods of time may experience symptoms of erectile dysfunction.
In severe cases, the intake of antihypertensive drugs for the long term can cause dermatitis, arthritis and anemia and lupus erythematosus-like syndrome, according to the article "Adverse Effects of Antihypertensive Drugs" written by Dr. DWARD D. FREIS, M.D.
If you are currently taking any anti-high blood pressure medications, please make you that you know all the side effects.
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia.
The kitchen spice has been used popularly in traditional and Chinese medicine in treating common cold and flu, blood pressure cholesterol levels, natural antibiotics, etc.
In adult men and women, participated in the Tehran Lipid and Glucose Study (2006-2008 to 2012-2014), the intake of garlic is associated to reduce the risk of hypertension by up 26%.
In hypertension of 80-90% of patients with excess glucocorticoid level, allicin found in garlic attenuated dexamethasone-induced anorexia and loss of total body weight.
A randomized, placebo-controlled, clinical trial conducted on 56 CVD patients, aged 25 - 75 years old also suggested treatment with garlic-based drugs can be effective for controlling BP in CVD patients and has no interaction with other drugs that CAD patients take, after 3 months of the administration.
Dr. Takashima M the lead author at the Wakunaga Pharmaceutical Co. Ltd said, " aged garlic extract (AGE) is effective in reducing the blood pressure of hypertensive patients,......AGE-induced the concentration-dependent vasorelaxation of isolated rat aortic rings that had been precontracted with norepinephrine"
In fact, traditional Chinese medicine, food therapy, and hypertension control, all recommended that garlic is of the food to be used for hypertension control, according to a statistical analysis of antihypertensive foods recommended in 20 books on the application of food therapy for hypertension control.
If you can control your diet, make changes to lifestyle, maintaining an ideal weight, you could do just fine without the drugs,
Taking all together, garlic may be used as preventive and controlling effects for patients with or without high blood pressure. Some researchers insisted that garlic anti-hypertension effect may result from its anticoagulant property.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats by Dubey H1,2, Singh A1, Patole AM2, Tenpe CR2(PubMed)
(2) Allium vegetable intakes and the incidence of cardiovascular disease, hypertension, chronic kidney disease, and type 2 diabetes in adults: a longitudinal follow-up study by Bahadoran Z1, Mirmiran P, Momenan AA, Azizi F.(PubMed)
(3) Does Garlic Supplementation Control Blood Pressure in Patients with Severe Coronary Artery Disease? A Clinical Trial Study by Mahdavi-Roshan M1, Nasrollahzadeh J1, Mohammad Zadeh A2, Zahedmehr A3. (PubMed)
(4) Traditional Chinese Medicine, Food Therapy, and Hypertension Control: A Narrative Review of Chinese Literature by Zou P1(PubMed)
(5) The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells by Vilaseca M1,2, García-Calderó H1,3, Lafoz E1,2, García-Irigoyen O3,4, Avila MA3,4, Reverter JC5, Bosch J1,2,3,6, Hernández-Gea V1,3, Gracia-Sancho J1,2,3, García-Pagán JC1,2,3(PubMed)
Cleaver(Galium aparine) Kills Resistant Laryngeal Cancer Cells in Vitro
The larynx is also known as the voice box, located between the pharynx and the trachea. Its function is to ensure the airways to open when we breathe and talk and closed when we swallow to ensure no food gets into the trachea.
Laryngeal cancer is a medical condition characterized by irregular cell growth in the tissues of the larynx. The cancer cells may spread to other tissues and organs in the late stage via lymph and blood circulation.
The exact cause of laryngeal cancer is unknown. Researchers do not know why people in the same family with the same health conditions and gender, some are susceptible to the onset of the disease while others do not.
However, they do know that certain risk factors such as smoking, excessive alcohol drinking, unhealthy diet, family history, HPV infection and long-term exposure to some chemicals including wood dust, soot coal dust, and paint fumes can increase the risk of cancer.
Genetic mutation inherited from the parents, such as TP53, GSTM3 and NAT2 and long-term use of some medication, such as immune-suppressive drugs to fight off infections such as HIV or AIDs is considered the prevalent risk factors for the disease development.
The most common symptoms of larynx (Voice Box) cancer include
* Hoarseness or other voice changes
Due to malignant cells have invaded the vocal cords.
* A cough that doesn't go away or stridor
Due to blocking of the airway.
* Breathing difficulties
The tumor has grown large enough to block off the airway.
* Ear pain
The tumor has pressed onto the nerve.
*A lump or mass in the neck or throat
Cancer gas invaded the nearby lymph nodes in the neck and throat.
* Coughing up of blood
Breaking off of some malignant cells.
Cleaver is a herbaceous annual plant, genus Galium, belongings to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
On finding a potential compound for the treatment of cancer, researchers investigated a Galium verum decoction in chemosensitive (Hep-2 and HLaC79) and chemoresistant, P-glycoprotein-overexpressing (Hep2-Tax, HLaC79-Tax) laryngeal carcinoma cell lines.
According to the results from the detailed spheroid-based 3D invasion analysis of Hep2 and Hep2-Tax in semisolid collagen gels and on different extracellular matrix coatings, Galium decoction proved to be even more pronounced in the more aggressively invading chemoresistant Hep2-Tax cell line compared to the administration of Galium aqueous extract.
Furthermore, the application of decoction also inhibited the expression of the enzyme gelatinolytic activity produced by the MMP-2 in three of the four cell lines without affecting the angiogenesis in the tested cell lines.
Interestingly, Galium decoction demonstrated an anti HLaC79 and Hep2, Hep2-Tax and HLaC79-Taxactivity with no influencing unique pathway activation.
Based on the findings, researchers said, " the intake of HCA has preventive effects on bone loss in STZ-diabetic rats, and that the intake has partially restorative effects on serum biochemical findings in the diabetic state".
Taken altogether, herbal cleaver may be considered as an anti resistant laryngeal cancer remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Galium verum aqueous extract on growth, motility and gene expression in drug-sensitive and -resistant laryngeal carcinoma cell lines by Schmidt M1, Scholz CJ2, Gavril GL3, Otto C1, Polednik C1, Roller J1, Hagen R. (PubMed)
Laryngeal cancer is a medical condition characterized by irregular cell growth in the tissues of the larynx. The cancer cells may spread to other tissues and organs in the late stage via lymph and blood circulation.
The exact cause of laryngeal cancer is unknown. Researchers do not know why people in the same family with the same health conditions and gender, some are susceptible to the onset of the disease while others do not.
However, they do know that certain risk factors such as smoking, excessive alcohol drinking, unhealthy diet, family history, HPV infection and long-term exposure to some chemicals including wood dust, soot coal dust, and paint fumes can increase the risk of cancer.
Genetic mutation inherited from the parents, such as TP53, GSTM3 and NAT2 and long-term use of some medication, such as immune-suppressive drugs to fight off infections such as HIV or AIDs is considered the prevalent risk factors for the disease development.
The most common symptoms of larynx (Voice Box) cancer include
* Hoarseness or other voice changes
Due to malignant cells have invaded the vocal cords.
* A cough that doesn't go away or stridor
Due to blocking of the airway.
* Breathing difficulties
The tumor has grown large enough to block off the airway.
* Ear pain
The tumor has pressed onto the nerve.
*A lump or mass in the neck or throat
Cancer gas invaded the nearby lymph nodes in the neck and throat.
* Coughing up of blood
Breaking off of some malignant cells.
Cleaver is a herbaceous annual plant, genus Galium, belongings to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
On finding a potential compound for the treatment of cancer, researchers investigated a Galium verum decoction in chemosensitive (Hep-2 and HLaC79) and chemoresistant, P-glycoprotein-overexpressing (Hep2-Tax, HLaC79-Tax) laryngeal carcinoma cell lines.
According to the results from the detailed spheroid-based 3D invasion analysis of Hep2 and Hep2-Tax in semisolid collagen gels and on different extracellular matrix coatings, Galium decoction proved to be even more pronounced in the more aggressively invading chemoresistant Hep2-Tax cell line compared to the administration of Galium aqueous extract.
Furthermore, the application of decoction also inhibited the expression of the enzyme gelatinolytic activity produced by the MMP-2 in three of the four cell lines without affecting the angiogenesis in the tested cell lines.
Interestingly, Galium decoction demonstrated an anti HLaC79 and Hep2, Hep2-Tax and HLaC79-Taxactivity with no influencing unique pathway activation.
Based on the findings, researchers said, " the intake of HCA has preventive effects on bone loss in STZ-diabetic rats, and that the intake has partially restorative effects on serum biochemical findings in the diabetic state".
Taken altogether, herbal cleaver may be considered as an anti resistant laryngeal cancer remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Galium verum aqueous extract on growth, motility and gene expression in drug-sensitive and -resistant laryngeal carcinoma cell lines by Schmidt M1, Scholz CJ2, Gavril GL3, Otto C1, Polednik C1, Roller J1, Hagen R. (PubMed)
Monday, March 16, 2020
Herbal Ashwagandha Protects in Post-Ischemic Reperfusion Injury in Vivo
Acute brain infarction is the medical condition characterized by the obstruction of the blood supply to the brain, causing the local death of the brain tissue.
The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.
In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.
Myocardial infarction (MI), or heart attack is a condition caused by the decrease or blockage of blood flow to a part of the heart that damage the heart muscle.
Reperfusion injury or ischemia-reperfusion injury (IRI) or reoxygenation injury, when blood supply returns to damaged tissues after a period of ischemia or lack of oxygen (anoxia or hypoxia). caused by the decrease or blockage of blood flow to a part of the heart.
Atherosclerosis, one of the major causes of cardiovascular disease is a medical condition caused by the accumulation of plaque on the arterial wall. Over time, the condition can lead to narrowing the arteries or blocked arteries, leading to reduce oxygenated blood flow to the heart and other parts of the body.
Arteries are blood vessels carried the oxygen-rich blood to the heart before passing them to the tissues and organs.
Plague is made up of fat, cholesterol, calcium, and other substances found in the blood. In other words, cholesterol that cannot be returned to the liver for reuse may have a strong impact to induce plaque accumulation.
There are many factors associated with the risk of acute infarction. However, aging may have a strong and negative implication on acute infarction.
Dr. Mehta RH, the lead scientist wrote, "Older age was associated with a greater proportion of patients with functional limitations, heart failure, prior coronary disease, and renal insufficiency and a lower proportion of male and diabetic patients".
And, "...age-associated differences in clinical characteristics in elderly patients with acute myocardial infarction (AMI), which account for some of the age-associated differences in mortality".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the promotion of heart health, researchers evaluated the cardioprotective mechanisms of Withania somnifera (Ws), in the setting of ischemia and reperfusion (IR) injury.
In vivo, selected Wistar rats were divided into three groups received orally saline (sham, control IR) and Ws-50 mg/kg (Ws-IR), respectively, for 1 month. Then, on day 31, rats of control IR and Ws-IR group, LAD coronary artery occlusion was undertaken for 45 min followed by 1 h reperfusion.
Based on the tested analysis, post-ischemic reperfusion injury was found to induce significant cardiac necrosis, apoptosis, and a decline in antioxidant status.
Furthermore, elevation in lipid peroxidation was also found in the IR control group, compared to the sham group.
Ws treatment group not only restored the myocardial oxidant-antioxidant balance but also inhibited the makers of apoptotic effects induced by ischemia-reperfusion injury.
Moreover, Ws protects additional post-ischemic reperfusion injury-induced further myocardial damage in the tested rats by increasing the levels of proteins associated with anti-apoptotic activity and decreasing the protein involved in pro-apoptotic activity, evidenced by histopathologic evaluation.
Based on the findings, researchers said, "The antioxidant and anti-apoptotic properties of Ws may contribute to the cardioprotective effects.".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of myocardial damage in post-ischemic reperfusion injury, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withania somnifera provides cardioprotection and attenuates ischemia-reperfusion induced apoptosis by Mohanty IR1, Arya DS, Gupta SK. (PubMed)
(2) Acute myocardial infarction in the elderly: differences by age by Mehta RH1, Rathore SS, Radford MJ, Wang Y, Wang Y, Krumholz HM. (PubMed)
The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.
In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.
Myocardial infarction (MI), or heart attack is a condition caused by the decrease or blockage of blood flow to a part of the heart that damage the heart muscle.
Reperfusion injury or ischemia-reperfusion injury (IRI) or reoxygenation injury, when blood supply returns to damaged tissues after a period of ischemia or lack of oxygen (anoxia or hypoxia). caused by the decrease or blockage of blood flow to a part of the heart.
Atherosclerosis, one of the major causes of cardiovascular disease is a medical condition caused by the accumulation of plaque on the arterial wall. Over time, the condition can lead to narrowing the arteries or blocked arteries, leading to reduce oxygenated blood flow to the heart and other parts of the body.
Arteries are blood vessels carried the oxygen-rich blood to the heart before passing them to the tissues and organs.
Plague is made up of fat, cholesterol, calcium, and other substances found in the blood. In other words, cholesterol that cannot be returned to the liver for reuse may have a strong impact to induce plaque accumulation.
There are many factors associated with the risk of acute infarction. However, aging may have a strong and negative implication on acute infarction.
Dr. Mehta RH, the lead scientist wrote, "Older age was associated with a greater proportion of patients with functional limitations, heart failure, prior coronary disease, and renal insufficiency and a lower proportion of male and diabetic patients".
And, "...age-associated differences in clinical characteristics in elderly patients with acute myocardial infarction (AMI), which account for some of the age-associated differences in mortality".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the promotion of heart health, researchers evaluated the cardioprotective mechanisms of Withania somnifera (Ws), in the setting of ischemia and reperfusion (IR) injury.
In vivo, selected Wistar rats were divided into three groups received orally saline (sham, control IR) and Ws-50 mg/kg (Ws-IR), respectively, for 1 month. Then, on day 31, rats of control IR and Ws-IR group, LAD coronary artery occlusion was undertaken for 45 min followed by 1 h reperfusion.
Based on the tested analysis, post-ischemic reperfusion injury was found to induce significant cardiac necrosis, apoptosis, and a decline in antioxidant status.
Furthermore, elevation in lipid peroxidation was also found in the IR control group, compared to the sham group.
Ws treatment group not only restored the myocardial oxidant-antioxidant balance but also inhibited the makers of apoptotic effects induced by ischemia-reperfusion injury.
Moreover, Ws protects additional post-ischemic reperfusion injury-induced further myocardial damage in the tested rats by increasing the levels of proteins associated with anti-apoptotic activity and decreasing the protein involved in pro-apoptotic activity, evidenced by histopathologic evaluation.
Based on the findings, researchers said, "The antioxidant and anti-apoptotic properties of Ws may contribute to the cardioprotective effects.".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of myocardial damage in post-ischemic reperfusion injury, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withania somnifera provides cardioprotection and attenuates ischemia-reperfusion induced apoptosis by Mohanty IR1, Arya DS, Gupta SK. (PubMed)
(2) Acute myocardial infarction in the elderly: differences by age by Mehta RH1, Rathore SS, Radford MJ, Wang Y, Wang Y, Krumholz HM. (PubMed)
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