Chamomile, the Antimicrobial Whole Herb Medicine in Accelerated Wound Healing

Chamomile, exerted its biotic property in accelerated the progression of wound healing by inhibiting Pseudomonas aeruginosa, in vivo.

According to the Shiraz University of Medical Sciences, treatment of 5% C. Nobile ointment extract from chamomile in rat wounds infected induced by P. aeruginosa, was more effective in the expression of antibacterial and wound healing activities in comparison to tetracycline, the antibiotic medicine.

The chamomile noble, in the Pseudomonas aeruginosa biofilm formation isolated from wound infections, also showed a remarkable inhibitory concentration of 6.25-25mg/ml.


Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.

Dr. Kazemian H. the lead researcher at the joint study said, " C. Nobile may play an important role in its antibacterial activity, thus offering an additional strategy in the fight against bacterial infections. and "However, the molecular investigation is required to explore the exact mechanisms of the antibacterial action and functions of this phytocompound".

Furthermore, in the testing of the effect of chamomile compounds in several models of toxicity (acute toxicity against Artemia salina and cytotoxicity against two cell lines (fibroblast and melanoma)), researchers suggested that these compounds showed low to moderate activity in all tests of acetylcholinesterase inhibitory and antibacterial activities.

And the intake of these compounds in naturally available amounts, on their own, would probably not represent a risk to human health but the possible adverse interactions with the plant matrix should not be neglected.


Therefore, people who intend to use chamomile for reduced risk and treatment of various diseases should be cautious to prevent overdoses' toxicity.




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Sources
(1) In vivo antibacterial and wound healing activities of Roman chamomile (Chamaemelum nobile) by Kazemian H, Ghafourian S, Sadeghifard N, Badakhsh B, Heidari H1, Taji A, Shavalipour A, Mohebi R, Ebrahim-Saraie HS, Houri H, Houshmandfar R.(PubMed)
(2) Antibacterial, anti-swarming and anti-biofilm formation activities of Chamaemelum nobile against Pseudomonas aeruginosa by Kazemian H1, Ghafourian S1, Heidari H2, Amiri P3, Yamchi JK4, Shavalipour A3, Houri H3, Maleki A1, Sadeghifard N1.(PubMed)
(3) Toxic essential oils. Part III: identification and biological activity of new allylmethoxyphenyl esters from a Chamomile species (Anthemis segetalis Ten.) by Radulović NS1, Mladenović MZ, Blagojević PD, Stojanović-Radić ZZ, Ilic-Tomic T, Senerovic L, Nikodinovic-Runic J.(PubMed)