Infection is an inflammatory condition caused by a microbial invasion on body tissues
Most cases of bacterial infection are treated with antibiotics. However, bacteria are very adaptable, overuse of antibiotics has been found to make them resistant to antibiotics.
The most common symptoms of bacterial infection include redness and heat, swelling, fever, pain at the site of infection.
Urinary tract infection (UTIs) mostly occurred in women is an infection that affects the bladder and urethra caused mostly by bacterial strains Escherichia coli (E. coli), commonly found in the gastrointestinal (GI) tract.
UTIs have been found to limit the function of the bladder and induce kidney infection.
The most common symptoms of urinary infection are a persistent urge to urinate, urinary burning sensation, cloudy urine, and smelly urine.
In severe cases, patients may also experience symptoms of blood in the urine and bladder and pelvic pain.
The most common risk factors of urinary tract infection are gender, females are more like to have UTI compared to males, sexual activity, use of birth control, and menopausal women.
Some researchers suggested that sexual intercourse may increase the risk of symptomatic urinary tract infection in postmenopausal women.
Dr. Elya E. Moore, the lead scientist in the joint study lead by the University of Washington School of Public Health and Community Medicine wrote, ".., as with younger women, sexual intercourse is strongly associated with UTI in post-menopausal women, supporting a common mechanism for infection among women of widely varying ages".
And, " This finding emphasizes the clinical importance of inquiring about recent sexual intercourse when treating post-menopausal women for symptomatic urinary tract infections".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of urinary infection, researchers examined the effect of cranberry anti urinary tract infections (UTIs) activity.
Based on the analysis, cranberry consumption showed a significant effect on decreasing UTI related symptoms by suppressing inflammatory associated with the immunologic response to pathogenic invasion by eradicating the bacteria.
Furthermore, injection of cranberry against UTIs was also found to prevent the development of infections only in populations at lower risk for contracting UTIs compared to low effective in a higher risk population.
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of UTIs, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry for Urinary Tract Infection: From Bench to Bedside by Nabavi SF, Sureda A, Daglia M, Izadi M, Nabavi SM. (PubMed)
(2) Current clinical status on the preventive effects of cranberry consumption against urinary tract infections by Vasileiou I1, Katsargyris A, Theocharis S, Giaginis C. (PubMed)
(3) Sexual Intercourse and Risk of Symptomatic Urinary Tract Infection in Post-Menopausal Women by Elya E. Moore, Ph.D. Stephen E. Hawes, Ph.D.,1 Delia Scholes, Ph.D.,1,3 Edward J. Boyko, MD, MPH,1,4,5 James P. Hughes, Ph.D.,6 and Stephan D. Fihn, MD, MPH. (PubMed)
Friday, April 10, 2020
Thursday, April 9, 2020
Herbal Chamomile Extracts That Normalize the (Over and Under Active) Function of Immune System
Chamomile (Matricaria chamomilla), in a recent study conducted by some renowned institutions, restored the resistance against lethal infection with the predominately granulocyte-dependant Candida albicans in immunosuppressed mice.
The immune system is the set of cells comprised of the body's defense system against diseases.
In normal immunity, active immunity may also be artificially acquired active immunity caused by the injection of the vaccine, a substance that contains antigen and passive immunity is an auto-response of immune system against infection through the production of antigen.
Immunity can also be passive and active, Dr. David Baxter, in the article of "Active and passive immunity, vaccine types, excipients and licensing" wrote, "Active immunity refers to the process of exposing the body to an antigen to generate an adaptive immune response: the response takes days/weeks to develop but may be long-lasting—even lifelong" and " Passive immunity refers to the process of providing IgG antibodies to protect against infection; it gives immediate, but short-lived protection—several weeks to 3 or 4 months at most. Passive immunity is usually classified as natural or acquired"(3).
However, an abnormal immune response such as overactive and underactive may cause a weakened immune system or autoimmune diseases.
The common characteristic of overactive immunity is the immune system that attacks healthy tissues, thus provoking inflammation, as well as tissue and organ damage. Truly, there are an estimated 80 autoimmune diaereses, that affect 14–22 million Americans, or 5%–8% of the population, and their prevalence is on the rise, according to the US National Institutes of Health (NIH)(4).
Underactive immunity can be a primary immune deficiency or acquired immune deficiency. People with weakened immunity, regardless of the cause are at constant danger of infections from bacteria, viruses, and fungi.
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae,
The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
In the study to examine the immunomodulatory effect of a group of the medicinal plant including Silene (Silene Nocturna), Black seed (Nigella sativa) and Chamomile (Matricaria chamomilla) growing in Egypt in Balb/c mice, researchers found that intraperitoneal injection chamomile methanolic extract was found to enhance immunity through the increased total white blood cells count(1).
In comparison to other plant extracts, chamomile extracts also increased bone marrow cellularity significantly(1).
Furthermore, spleen weight of chamomile treated groups was significantly increased. increased weight of spleen is an indication of improved immune activity as spleen plays an important role in the modulation of the immune system and in the maintenance of peripheral tolerance via the clearance of circulating apoptotic cells, the differentiation and activation of T and B cells and production of antibodies(5)
In groups induced immunosuppressed with cyclophosphamide, group pretreated with the chamomile extracts inhibit Candida significantly through restored their resistance against lethal infection with the predominately granulocyte-dependant Candida albicans(1).
Dr. Ghonime M, the lead author said, These results confirm the immunomodulatory activity of Silene, Black seed, and Chamomile extracts and may have therapeutical implications in the prophylactic treatment of opportunistic infections and as supportive treatment in oncogenic cases".
According to the Russian State Medical University, Moscow, heteropolysaccharides, a class of sugars, found in Matricaria chamomilla L. showed to normalize the development of the immune response upon air cooling.
These results are attributed to chamomile heteropolysaccharides effects in initiated immunostimulating properties of heavy erythrocytes (macrocytes), the group of enlargement of red blood cells, activated of immunoregulation of cells of peripheral blood and increased the sensitivity of effector cells to helper signals.
Dr. Ghonime M, the lead author, said, "immunomodulatory activity,.....Chamomile extracts may have therapeutical implications in the prophylactic treatment of opportunistic infections and as supportive treatment in oncogenic cases".
There is no doubt that chamomile and its chemical ingredients have expressed a strong immunomodulatory activity in the protection of our body against various diseases, but the intake of large quantities should be taken with care to avoid toxicity.
However, further data collection on large example size and multi-centers studies performed with human consumption of the chamomile extracts during the course of the disease will be necessary to complete the picture of chamomile immunomodulatory possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of immunomodulatory effect of three herbal plants growing in Egypt by Ghonime M1, Eldomany R, Abdelaziz A, Soliman H.(PubMed)
(2) [The immunomodulating activity of the heteropolysaccharides from German chamomile(Matricaria chamomilla) during air and immersion cooling].[Article in Russian] by Uteshev BS1, Laskova IL, Afanas'ev VA.(PubMed)
(3) Active and passive immunity, vaccine types, excipients and licensing by David Baxter(Oxford Academic)
(4) When the immune system goes on the attack by Vicki Brower(PMC)
(5) Liver-spleen axis: Intersection between immunity, infections and metabolism by Giovanni Tarantino, Antonella Scalera, and Carmine Finelli(PMC)
The immune system is the set of cells comprised of the body's defense system against diseases.
In normal immunity, active immunity may also be artificially acquired active immunity caused by the injection of the vaccine, a substance that contains antigen and passive immunity is an auto-response of immune system against infection through the production of antigen.
Immunity can also be passive and active, Dr. David Baxter, in the article of "Active and passive immunity, vaccine types, excipients and licensing" wrote, "Active immunity refers to the process of exposing the body to an antigen to generate an adaptive immune response: the response takes days/weeks to develop but may be long-lasting—even lifelong" and " Passive immunity refers to the process of providing IgG antibodies to protect against infection; it gives immediate, but short-lived protection—several weeks to 3 or 4 months at most. Passive immunity is usually classified as natural or acquired"(3).
However, an abnormal immune response such as overactive and underactive may cause a weakened immune system or autoimmune diseases.
The common characteristic of overactive immunity is the immune system that attacks healthy tissues, thus provoking inflammation, as well as tissue and organ damage. Truly, there are an estimated 80 autoimmune diaereses, that affect 14–22 million Americans, or 5%–8% of the population, and their prevalence is on the rise, according to the US National Institutes of Health (NIH)(4).
Underactive immunity can be a primary immune deficiency or acquired immune deficiency. People with weakened immunity, regardless of the cause are at constant danger of infections from bacteria, viruses, and fungi.
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae,
The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
In the study to examine the immunomodulatory effect of a group of the medicinal plant including Silene (Silene Nocturna), Black seed (Nigella sativa) and Chamomile (Matricaria chamomilla) growing in Egypt in Balb/c mice, researchers found that intraperitoneal injection chamomile methanolic extract was found to enhance immunity through the increased total white blood cells count(1).
In comparison to other plant extracts, chamomile extracts also increased bone marrow cellularity significantly(1).
Furthermore, spleen weight of chamomile treated groups was significantly increased. increased weight of spleen is an indication of improved immune activity as spleen plays an important role in the modulation of the immune system and in the maintenance of peripheral tolerance via the clearance of circulating apoptotic cells, the differentiation and activation of T and B cells and production of antibodies(5)
In groups induced immunosuppressed with cyclophosphamide, group pretreated with the chamomile extracts inhibit Candida significantly through restored their resistance against lethal infection with the predominately granulocyte-dependant Candida albicans(1).
Dr. Ghonime M, the lead author said, These results confirm the immunomodulatory activity of Silene, Black seed, and Chamomile extracts and may have therapeutical implications in the prophylactic treatment of opportunistic infections and as supportive treatment in oncogenic cases".
According to the Russian State Medical University, Moscow, heteropolysaccharides, a class of sugars, found in Matricaria chamomilla L. showed to normalize the development of the immune response upon air cooling.
These results are attributed to chamomile heteropolysaccharides effects in initiated immunostimulating properties of heavy erythrocytes (macrocytes), the group of enlargement of red blood cells, activated of immunoregulation of cells of peripheral blood and increased the sensitivity of effector cells to helper signals.
Dr. Ghonime M, the lead author, said, "immunomodulatory activity,.....Chamomile extracts may have therapeutical implications in the prophylactic treatment of opportunistic infections and as supportive treatment in oncogenic cases".
There is no doubt that chamomile and its chemical ingredients have expressed a strong immunomodulatory activity in the protection of our body against various diseases, but the intake of large quantities should be taken with care to avoid toxicity.
However, further data collection on large example size and multi-centers studies performed with human consumption of the chamomile extracts during the course of the disease will be necessary to complete the picture of chamomile immunomodulatory possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of immunomodulatory effect of three herbal plants growing in Egypt by Ghonime M1, Eldomany R, Abdelaziz A, Soliman H.(PubMed)
(2) [The immunomodulating activity of the heteropolysaccharides from German chamomile(Matricaria chamomilla) during air and immersion cooling].[Article in Russian] by Uteshev BS1, Laskova IL, Afanas'ev VA.(PubMed)
(3) Active and passive immunity, vaccine types, excipients and licensing by David Baxter(Oxford Academic)
(4) When the immune system goes on the attack by Vicki Brower(PMC)
(5) Liver-spleen axis: Intersection between immunity, infections and metabolism by Giovanni Tarantino, Antonella Scalera, and Carmine Finelli(PMC)
Wednesday, April 8, 2020
Herbal Chaste Tree Berry Normalizes Menstrual Cycle and Enhanced Pregnancy in Women with Oligomenorrhea
A renowned study suggested that Chaste tree berry has a potential effect in enhancing pregnancy in women with the abnormal menstrual cycle.
Fertility is a natural process to ensure the survival of human species. Through natural selection, we produce many offspring when the reproductive system works at its peak in a suitable environment with plenty of food around. On the other hand, the reproductive system may completely shut down or work at its minimum state and we produce less offspring when the environment is hostile including fewer foods around, war, epidemic.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
In a total of 37 women with oligomenorrhea and 30 women with amenorrhea received 50 drops of Phyto Hypophyson L, a preparation from Chaste tree berry or placebo 3 times a day over 3 months or 3 cycles, the preparation not only normalized the menstrual cycle of women with oligomenorrhea but also significantly improved the chance of pregnancy, compared placebo group.
Dr. Bergmann J, the lead author said, " The baby take-home rate during the therapy and 6 months after the end of the therapy showed a ratio of 18.7 /6.4%)".
The effectiveness of the preparation in an enhanced rate of pregnancy with remarkable outcome maybe
due to the increase of progesterone during the luteal phase compared to the oligomenorrhea placebo group, with only very few undesirable side effects.
In another study with the same group of women, researchers found that treatment of preparation to women with sterility and oligomenorrhea can induce pregnancy over a period of 3-6 months with an attractive rate.
Promisingly, in a randomized double-blind study to test the effect of Vitex agnus castus preparation (Strotan capsules) vs. placebo, involved 52 women with luteal phase defects due to latent hyperprolactinaemia, women who are taking the daily dose of one capsule (20 mg) Vitexagnus cactus preparation reserved the elevated pituitary prolactin and normalized deficits in luteal phase length and increased luteal phase progesterone synthesis. comparable to placebo, after three months of therapy.
Dr. Milewicz A, the lead researcher said, "Side effects were not seen, two women treated with the Vitex agnus castus preparation got pregnant. The tested preparation is thought to be an efficient medication in the treatment of luteal phase defects due to latent hyperprolactinemia".
Taking together, Chaste tree berry may have a pharmaceutical value in promoting pregnancy in women with sterility and oligomenorrhea, but large doses should be taken with care against toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Double-blind, placebo-controlled study of Fertilityblend: a nutritional supplement for improving fertility in women by Westphal LM1, Polan ML, Trant AS.(PubMed)
(2) [Vitex agnus castus extract in the treatment of luteal phase defects due to latenthyperprolactinemia. Results of a randomized placebo-controlled double-blind study].
[Article in German]by Milewicz A1, Gejdel E, Sworen H, Sienkiewicz K, Jedrzejak J, Teucher T, Schmitz H.(PubMed)
(3) [The efficacy of the complex medication Phyto-Hypophyson L in female, hormone-related sterility. A randomized, placebo-controlled clinical double-blind study].[Article in German]by Bergmann J1, Luft B, Boehmann S, Runnebaum B, Gerhard I.(PubMed)
Fertility is a natural process to ensure the survival of human species. Through natural selection, we produce many offspring when the reproductive system works at its peak in a suitable environment with plenty of food around. On the other hand, the reproductive system may completely shut down or work at its minimum state and we produce less offspring when the environment is hostile including fewer foods around, war, epidemic.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
In a total of 37 women with oligomenorrhea and 30 women with amenorrhea received 50 drops of Phyto Hypophyson L, a preparation from Chaste tree berry or placebo 3 times a day over 3 months or 3 cycles, the preparation not only normalized the menstrual cycle of women with oligomenorrhea but also significantly improved the chance of pregnancy, compared placebo group.
Dr. Bergmann J, the lead author said, " The baby take-home rate during the therapy and 6 months after the end of the therapy showed a ratio of 18.7 /6.4%)".
The effectiveness of the preparation in an enhanced rate of pregnancy with remarkable outcome maybe
due to the increase of progesterone during the luteal phase compared to the oligomenorrhea placebo group, with only very few undesirable side effects.
In another study with the same group of women, researchers found that treatment of preparation to women with sterility and oligomenorrhea can induce pregnancy over a period of 3-6 months with an attractive rate.
Promisingly, in a randomized double-blind study to test the effect of Vitex agnus castus preparation (Strotan capsules) vs. placebo, involved 52 women with luteal phase defects due to latent hyperprolactinaemia, women who are taking the daily dose of one capsule (20 mg) Vitexagnus cactus preparation reserved the elevated pituitary prolactin and normalized deficits in luteal phase length and increased luteal phase progesterone synthesis. comparable to placebo, after three months of therapy.
Dr. Milewicz A, the lead researcher said, "Side effects were not seen, two women treated with the Vitex agnus castus preparation got pregnant. The tested preparation is thought to be an efficient medication in the treatment of luteal phase defects due to latent hyperprolactinemia".
Taking together, Chaste tree berry may have a pharmaceutical value in promoting pregnancy in women with sterility and oligomenorrhea, but large doses should be taken with care against toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Double-blind, placebo-controlled study of Fertilityblend: a nutritional supplement for improving fertility in women by Westphal LM1, Polan ML, Trant AS.(PubMed)
(2) [Vitex agnus castus extract in the treatment of luteal phase defects due to latenthyperprolactinemia. Results of a randomized placebo-controlled double-blind study].
[Article in German]by Milewicz A1, Gejdel E, Sworen H, Sienkiewicz K, Jedrzejak J, Teucher T, Schmitz H.(PubMed)
(3) [The efficacy of the complex medication Phyto-Hypophyson L in female, hormone-related sterility. A randomized, placebo-controlled clinical double-blind study].[Article in German]by Bergmann J1, Luft B, Boehmann S, Runnebaum B, Gerhard I.(PubMed)
Tuesday, April 7, 2020
Turmeric, the Potential Spice that Detoxes Your Lung Against Toxicity
Lung toxicity or pulmonary toxicity refers to the toxicity induced by the side effects of the lung in patients under chemotherapy or radiotherapy.
The most common drugs associated with lung toxicity used for the treatment of cancer include Arsenic trioxide (Trisenox®) Bleomycin (Blenoxane®)1 Idarubicin (Idamycin®).
However, lung toxicity is also caused by inhaling chemical compounds, the most famous (infamous) example is pulmonary toxicity due to asbestos. air pollution and airborne particulate matter produced by car traffic, overland traffic (trucks), industrial production facilities, and cigarette smoking.
Symptoms of lung damage or toxicity are a shortage of breath, breathlessness during exercise, fatigue dry cough Shortness of breath, particularly the symptoms that worsen when lying on your back breath.
Acute pulmonary toxicity, the damage to the lungs that resolves with a short period of time by addressing the cause.
Conventionally, most common treatments of lung toxicity are the use of
* Corticosteroids to decrease inflammation and relieve the cough and pain
*Narcotics to reduce pain medications and promote breathing center
* Oxygen therapy to increase oxygen in the blood and prevent shortness of breath.
In severe cases, patients may be sent to the hospital for pulmonary (lung) rehabilitation.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of lung toxicity scientists evaluated the protective effects of curcumin on lipid peroxidation and antioxidants status in bronchoalveolar lavage fluid (BALF) and bronchoalveolar lavage (BAL) of a nicotine-treated animal model.
Wistar rats selected to the study were induced lung toxicity by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (5 days a week, for 22 weeks) and following by administration of curcumin (80 mg/kg body weight) given simultaneously by intragastric intubation for 22 weeks.
Before injecting curcumin, injection of nicotine rats showed the increased biochemical marker enzymes, lipid peroxides in BALF and BAL accompanied by a significant decrease in the levels of antioxidants in the lung.
Following the treatment of curcumin, infected rats showed a significantly lowered the biochemical marker enzymes, lipid peroxidation and enhanced the antioxidant status.
Based on the results, researchers said, "The results of the present study suggest that curcumin exerts its protective effect against nicotine-induced lung toxicity by modulating the biochemical marker enzymes, lipid peroxidation and augmenting antioxidant defense system".
In order to reveal more information about turmeric detoxed activity, researchers examined the protective role of curcumin and a synthetic analog of curcumin (BDMC-A) on nicotine-induced oxidative stress.
Male albino rats of Wistar strain selected to the study induced lung toxicity by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (five days a week, for 22 weeks) and followed by the treatment of curcuminoids given simultaneously by intragastric intubation for 22 weeks.
Nicotine-treated groups before injection of curcumin showed increased oxidative stress, as evidenced by lipid peroxidation indices.
Injection of curcumin and BDMC-A not only restored the antioxidant status which was decreased in the nicotine-treated group.
Based on the findings, researchers said, "The present study suggests that BDMC-A exerts its protective effect by modulating the extent of lipid peroxidation and augmenting the antioxidant defense system".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of lung toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in Wistar rats by Kalpana C1, Menon VP. (PubMed)
(2) Comparative effects of curcumin and its synthetic analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity by Kalpana C1, Sudheer AR, Rajasekharan KN, Menon VP. (PubMed)
The most common drugs associated with lung toxicity used for the treatment of cancer include Arsenic trioxide (Trisenox®) Bleomycin (Blenoxane®)1 Idarubicin (Idamycin®).
However, lung toxicity is also caused by inhaling chemical compounds, the most famous (infamous) example is pulmonary toxicity due to asbestos. air pollution and airborne particulate matter produced by car traffic, overland traffic (trucks), industrial production facilities, and cigarette smoking.
Symptoms of lung damage or toxicity are a shortage of breath, breathlessness during exercise, fatigue dry cough Shortness of breath, particularly the symptoms that worsen when lying on your back breath.
Acute pulmonary toxicity, the damage to the lungs that resolves with a short period of time by addressing the cause.
Conventionally, most common treatments of lung toxicity are the use of
* Corticosteroids to decrease inflammation and relieve the cough and pain
*Narcotics to reduce pain medications and promote breathing center
* Oxygen therapy to increase oxygen in the blood and prevent shortness of breath.
In severe cases, patients may be sent to the hospital for pulmonary (lung) rehabilitation.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of lung toxicity scientists evaluated the protective effects of curcumin on lipid peroxidation and antioxidants status in bronchoalveolar lavage fluid (BALF) and bronchoalveolar lavage (BAL) of a nicotine-treated animal model.
Wistar rats selected to the study were induced lung toxicity by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (5 days a week, for 22 weeks) and following by administration of curcumin (80 mg/kg body weight) given simultaneously by intragastric intubation for 22 weeks.
Before injecting curcumin, injection of nicotine rats showed the increased biochemical marker enzymes, lipid peroxides in BALF and BAL accompanied by a significant decrease in the levels of antioxidants in the lung.
Following the treatment of curcumin, infected rats showed a significantly lowered the biochemical marker enzymes, lipid peroxidation and enhanced the antioxidant status.
Based on the results, researchers said, "The results of the present study suggest that curcumin exerts its protective effect against nicotine-induced lung toxicity by modulating the biochemical marker enzymes, lipid peroxidation and augmenting antioxidant defense system".
In order to reveal more information about turmeric detoxed activity, researchers examined the protective role of curcumin and a synthetic analog of curcumin (BDMC-A) on nicotine-induced oxidative stress.
Male albino rats of Wistar strain selected to the study induced lung toxicity by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (five days a week, for 22 weeks) and followed by the treatment of curcuminoids given simultaneously by intragastric intubation for 22 weeks.
Nicotine-treated groups before injection of curcumin showed increased oxidative stress, as evidenced by lipid peroxidation indices.
Injection of curcumin and BDMC-A not only restored the antioxidant status which was decreased in the nicotine-treated group.
Based on the findings, researchers said, "The present study suggests that BDMC-A exerts its protective effect by modulating the extent of lipid peroxidation and augmenting the antioxidant defense system".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of lung toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in Wistar rats by Kalpana C1, Menon VP. (PubMed)
(2) Comparative effects of curcumin and its synthetic analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity by Kalpana C1, Sudheer AR, Rajasekharan KN, Menon VP. (PubMed)
Monday, April 6, 2020
Green tea Polyphenols, the Potential Candidate for Treatment of Spinal Muscular Atrophy, Scientists Find
Scientists may have found a beverage which processes the ability to protect the central nervous system against the onset of spinal muscular atrophy, some studies suggested.
Spinal muscular atrophy (SMA) is a rare neuromuscular disorder affected the part of the nervous system that controls voluntary muscle movement due to the loss of motor neurons and progressive muscle wasting.
The disease is caused by a mutation in the SMN1 gene on chromosome 5. In some cases, the disease is also associated with a mutation in an X-chromosome gene called UBE1 causes X-linked SMA.
Depending on the disease severity, patients with SMA may experience symptoms of muscle weakness and decreased muscle tone, limited mobility, breathing problem, problems eating and swallowing, delayed gross motor skill and spontaneous tongue movements.
Green tea, a precious drink processes numbers of health benefits known to almost everyone in Asia and the Western world.
In the investigation to reexamine, the laboratory-based evidence suggest that purified polyphenol compounds such as resveratrol, found naturally in red grapes, epigallocatechin galate from green tea and curcumin from turmeric, might be useful for the treatment of various inherited neuromuscular diseases, including spinal muscular atrophy, researchers at the RJAH Orthopaedic Hospital launched an investigation to evaluate the scientific evidence related to the known molecular effects that these polyphenols have on different models of inherited neuromuscular disease, with particular attention to problems with the validity of in vitro evidence.
Application of polyphenols demonstrated the molecular effects on different models of inherited neuromuscular disease,
Polyphenols, in vitro, exerts a significant effect on cells through metal ion chelation in cell-culture media.
Dr. Fuller HR, the lead author after taking into account co and confounders said, "Polyphenols could be an attractive approach to therapy for the inherited neuromuscular disease, especially since they may be safer to use on young children, compared with some of the other drug candidates".
Additionally, in the assessment of Epigallocatechin-3-gallate (EGCG), a major component of green tea polyphenols effect on neuroprotection, researchers at The Second Hospital of Hebei Medical University found that injection of EGCG exerts substantial protection of motor neuron by regulating glutamate level in organotypic culture of rat spinal cord.
Further analysis suggested EGCG blocks the glutamate excitotoxicity caused by threohydroxyaspartate, an inhibitor of glutamate transporter not by its antioxidant activity but other unknown mechanisms. As another antioxidant could not regulate the glutamate level under the same condition in another study.
These results suggested that EGCG may be a potential therapeutic candidate for neurodegenerative diseases involving glutamate excitotoxicity, including SMA.
Taken altogether, green tea purified polyphenols may be considered an adjunct therapy combined with conventional medicine for the treatment of various inherited neuromuscular diseases, including spinal muscular atrophy
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases by Fuller HR1, Humphrey EL, Morris GE. (PubMed)
(3) Epigallocatechin-3-gallate protects motor neurons and regulates glutamate level by Yu J1, Jia Y, Guo Y, Chang G, Duan W, Sun M, Li B, Li C.(PubMed)
Spinal muscular atrophy (SMA) is a rare neuromuscular disorder affected the part of the nervous system that controls voluntary muscle movement due to the loss of motor neurons and progressive muscle wasting.
The disease is caused by a mutation in the SMN1 gene on chromosome 5. In some cases, the disease is also associated with a mutation in an X-chromosome gene called UBE1 causes X-linked SMA.
Depending on the disease severity, patients with SMA may experience symptoms of muscle weakness and decreased muscle tone, limited mobility, breathing problem, problems eating and swallowing, delayed gross motor skill and spontaneous tongue movements.
Green tea, a precious drink processes numbers of health benefits known to almost everyone in Asia and the Western world.
In the investigation to reexamine, the laboratory-based evidence suggest that purified polyphenol compounds such as resveratrol, found naturally in red grapes, epigallocatechin galate from green tea and curcumin from turmeric, might be useful for the treatment of various inherited neuromuscular diseases, including spinal muscular atrophy, researchers at the RJAH Orthopaedic Hospital launched an investigation to evaluate the scientific evidence related to the known molecular effects that these polyphenols have on different models of inherited neuromuscular disease, with particular attention to problems with the validity of in vitro evidence.
Application of polyphenols demonstrated the molecular effects on different models of inherited neuromuscular disease,
Polyphenols, in vitro, exerts a significant effect on cells through metal ion chelation in cell-culture media.
Dr. Fuller HR, the lead author after taking into account co and confounders said, "Polyphenols could be an attractive approach to therapy for the inherited neuromuscular disease, especially since they may be safer to use on young children, compared with some of the other drug candidates".
Additionally, in the assessment of Epigallocatechin-3-gallate (EGCG), a major component of green tea polyphenols effect on neuroprotection, researchers at The Second Hospital of Hebei Medical University found that injection of EGCG exerts substantial protection of motor neuron by regulating glutamate level in organotypic culture of rat spinal cord.
Further analysis suggested EGCG blocks the glutamate excitotoxicity caused by threohydroxyaspartate, an inhibitor of glutamate transporter not by its antioxidant activity but other unknown mechanisms. As another antioxidant could not regulate the glutamate level under the same condition in another study.
These results suggested that EGCG may be a potential therapeutic candidate for neurodegenerative diseases involving glutamate excitotoxicity, including SMA.
Taken altogether, green tea purified polyphenols may be considered an adjunct therapy combined with conventional medicine for the treatment of various inherited neuromuscular diseases, including spinal muscular atrophy
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases by Fuller HR1, Humphrey EL, Morris GE. (PubMed)
(3) Epigallocatechin-3-gallate protects motor neurons and regulates glutamate level by Yu J1, Jia Y, Guo Y, Chang G, Duan W, Sun M, Li B, Li C.(PubMed)
Sunday, April 5, 2020
Herbal Cascara Sagrada (Rhamnus purshiana), The Best for the Prevention and Treatment of Liver cancer
Herbal Cascara sagrada processed a bioactive compound emodin may have a significant and potential effect in reducing the risk and treatment of liver cancer, according to studies.
Liver cancer is a medical and chronic condition caused by irregular cell growth in the liver tissues, due to the alternation of cell DNA.
The liver organ is one of the organs with a lack of nerve tissue, therefore liver cancer does not induce pain until the later stage.
At the advanced stage of liver cancer, the cancer cell may travel a distance away to infect other tissues and organs, leading to secondary metastasis.
According to the statistics provided by the Canadian Cancer Society, every year, approximately, 1,900 men and 580 women are diagnosed with liver cancer, causing the death of 950 men and 270 women.
In 2017, 2,500 Canadians were diagnosed with liver cancer and 1,200 Canadians died from liver cancer.
Compared to the early stage of other cancer, the 5 years survival rate in the early stage diagnosis is only 31% and 43% of people with liver cancer diagnosed at stage 0 and 1.
The exact causes of liver cancer are unknown. However, chronic infection with hepatitis virus, cirrhosis, genetic preposition, a medical condition of diabetes, nonalcoholic fatty liver disease and excessive alcohol consumption are some of the most prevalent risk factors of liver cancer, epidemiologically.
Dr. Chuang SC, the lead scientist in the concern of excessive alcohol drinking in risk of liver cancer, wrote, "Compared to individuals who never drank or drank at very low frequencies, the meta-relative risk (mRR) forever drinkers was 1.29 (95% confidence interval, CI 1.16-1.42) and 1.46 (95% CI 1.27-1.65) for case-control studies".
And, "The dose-response relation between alcohol and liver cancer was apparent with RR = 1.08 (95% CI 1.04-1.11) for 12 g/day (~1 drink), 1.54 (95% CI 1.36-1.74) for 50 g/day, 2.14 (95% CI 1.74-2.62) for 75 g/day, 3.21 (95% CI 2.34-4.40) for 100 g/day, and 5.20 (95% CI 3.25-8.29) for 125 g/day of alcohol consumption".
The finding clearly suggested, one alcoholic drink per day (~12 g/day) may be associated with 1.1 times higher liver cancer risk and risk of liver cancer increases proportionally to the volume intake per day.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America. The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on finding a natural compound for the treatment of liver cancer examined the effect of emodin, a bioactive ingredient isolated from herbal Cascara Sagrada against CXCL12-CXCR4 signaling cascade which plays an important role in the process of invasion and metastasis of liver cancer.
Where The CXCL12/CXCR4 axis is a pathway involved in tumor progression, angiogenesis, metastasis, and survival.
Injection of emodin inhibited the expression of CXCR4 in a dose and time-dependent manner in HCC cells.
Treatment of emodin demonstrated a better effect compared to the pharmacological proteasome and lysosomal inhibitors on the decrease in CXCR4 expression.
The suppression of CXCR4 expression was attributed to several mechanisms, including the inhibition of cancer cells mRNA expression, a protein associated with cancer cell proliferation and production of antigens by innate immunity.
Furthermore, emodin treatment significantly suppressed metastasis to the lungs in an orthotopic HCC mice model and CXCR4 expression in tumor tissues.
In other human cancers cell lines, emodin-induced apoptosis in HepG2 cells through cell cycle arrest.
According to the Western blot data, emodin inhibited cancer cell growth through a set of mechanisms, including cell degradation and protein associated with cell death programming.
Moreover, application emodin increased the expression in the initiation of cytotoxicity against HepG2 without causing harm to the nearby healthy cells.
Additionally, emodin increased the protein p53 associated with tumor suppression and decreased the protein involved in cancer cell proliferation in HepG2 cells.
These results suggest that emodin induces apoptosis in the liver cancer cell line through a multifaceted complex cascade of events.
Taken altogether, herbal Cascara Sagrada processed a major bioactive compound emodin may be considered a functional remedy for the prevention and treatment of liver cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma by Manu KA, Shanmugam MK, Ong TH, Subramaniam A, Siveen KS, Perumal E, Samy RP, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G.(PubMed)
(2) Emodin regulates apoptotic pathway in human liver cancer cells by Yu JQ, Bao W, Lei JC.(PubMed)
(3) Apoptosis by aloe-emodin is mediated through down-regulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells by Jeon W, Jeon YK, Nam MJ.(PubMed)
(4) Alcohol consumption and liver cancer risk: a meta-analysis by Chuang SC1, Lee YC, Wu GJ, Straif K, Hashibe M. (PubMed)
Liver cancer is a medical and chronic condition caused by irregular cell growth in the liver tissues, due to the alternation of cell DNA.
The liver organ is one of the organs with a lack of nerve tissue, therefore liver cancer does not induce pain until the later stage.
At the advanced stage of liver cancer, the cancer cell may travel a distance away to infect other tissues and organs, leading to secondary metastasis.
According to the statistics provided by the Canadian Cancer Society, every year, approximately, 1,900 men and 580 women are diagnosed with liver cancer, causing the death of 950 men and 270 women.
In 2017, 2,500 Canadians were diagnosed with liver cancer and 1,200 Canadians died from liver cancer.
Compared to the early stage of other cancer, the 5 years survival rate in the early stage diagnosis is only 31% and 43% of people with liver cancer diagnosed at stage 0 and 1.
The exact causes of liver cancer are unknown. However, chronic infection with hepatitis virus, cirrhosis, genetic preposition, a medical condition of diabetes, nonalcoholic fatty liver disease and excessive alcohol consumption are some of the most prevalent risk factors of liver cancer, epidemiologically.
Dr. Chuang SC, the lead scientist in the concern of excessive alcohol drinking in risk of liver cancer, wrote, "Compared to individuals who never drank or drank at very low frequencies, the meta-relative risk (mRR) forever drinkers was 1.29 (95% confidence interval, CI 1.16-1.42) and 1.46 (95% CI 1.27-1.65) for case-control studies".
And, "The dose-response relation between alcohol and liver cancer was apparent with RR = 1.08 (95% CI 1.04-1.11) for 12 g/day (~1 drink), 1.54 (95% CI 1.36-1.74) for 50 g/day, 2.14 (95% CI 1.74-2.62) for 75 g/day, 3.21 (95% CI 2.34-4.40) for 100 g/day, and 5.20 (95% CI 3.25-8.29) for 125 g/day of alcohol consumption".
The finding clearly suggested, one alcoholic drink per day (~12 g/day) may be associated with 1.1 times higher liver cancer risk and risk of liver cancer increases proportionally to the volume intake per day.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America. The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on finding a natural compound for the treatment of liver cancer examined the effect of emodin, a bioactive ingredient isolated from herbal Cascara Sagrada against CXCL12-CXCR4 signaling cascade which plays an important role in the process of invasion and metastasis of liver cancer.
Where The CXCL12/CXCR4 axis is a pathway involved in tumor progression, angiogenesis, metastasis, and survival.
Injection of emodin inhibited the expression of CXCR4 in a dose and time-dependent manner in HCC cells.
Treatment of emodin demonstrated a better effect compared to the pharmacological proteasome and lysosomal inhibitors on the decrease in CXCR4 expression.
The suppression of CXCR4 expression was attributed to several mechanisms, including the inhibition of cancer cells mRNA expression, a protein associated with cancer cell proliferation and production of antigens by innate immunity.
Furthermore, emodin treatment significantly suppressed metastasis to the lungs in an orthotopic HCC mice model and CXCR4 expression in tumor tissues.
In other human cancers cell lines, emodin-induced apoptosis in HepG2 cells through cell cycle arrest.
According to the Western blot data, emodin inhibited cancer cell growth through a set of mechanisms, including cell degradation and protein associated with cell death programming.
Moreover, application emodin increased the expression in the initiation of cytotoxicity against HepG2 without causing harm to the nearby healthy cells.
Additionally, emodin increased the protein p53 associated with tumor suppression and decreased the protein involved in cancer cell proliferation in HepG2 cells.
These results suggest that emodin induces apoptosis in the liver cancer cell line through a multifaceted complex cascade of events.
Taken altogether, herbal Cascara Sagrada processed a major bioactive compound emodin may be considered a functional remedy for the prevention and treatment of liver cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma by Manu KA, Shanmugam MK, Ong TH, Subramaniam A, Siveen KS, Perumal E, Samy RP, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G.(PubMed)
(2) Emodin regulates apoptotic pathway in human liver cancer cells by Yu JQ, Bao W, Lei JC.(PubMed)
(3) Apoptosis by aloe-emodin is mediated through down-regulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells by Jeon W, Jeon YK, Nam MJ.(PubMed)
(4) Alcohol consumption and liver cancer risk: a meta-analysis by Chuang SC1, Lee YC, Wu GJ, Straif K, Hashibe M. (PubMed)
Saturday, April 4, 2020
Chamomile, The best Whole herb Medicine in Expression of Sedative Activities
Chamomile, the most frequently used medical plant maybe the next generation of the whole herb to act as a sedative agent in treating patients with sleep disorders.
A quasi-experimental clinical trial, included 77 cases of elderly hospitalized in nursing homes, showed that oral administration of chamomile extract has sedative properties in sleep quality.
Sedation is a form of medicine in induced calm and sleep.
The herbal medicine is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
In support of the sedative effect, chamomile cream also is found to reduce episiotomy pain sedately in primiparous women, according to a triple-blind clinical trial performed on 114 eligible women at Ommolbanin Hospital in Mashhad, Iran in 2014.
Dr. McKay DL said, " Chamomile has moderate antioxidant and antimicrobial activities, and significant antiplatelet activity Animal model studies indicate potent antiinflammatory action, some antimutagenic and cholesterol-lowering activities, as well as antispasmodic and anxiolytic effects" and "(Unfortunately) However, human studies are limited, and clinical trials examining the purported sedative properties of chamomile tea are absent."
In fact, in the investigated hypnotic activities of chamomile and passiflora extracts using sleep-disturbed model rats, researchers at the Okayama University insisted, chamomile extract at a dose of 300 mg/kg exerted significantly decrease sleep latency.
The study also suggested chamomile extract is a herb having benzodiazepine-like hypnotic activity.
Taking all together, Chamomile may be helpful to aid calm and sleep through its sedative effects, but intake of the correct amount should only be given by qualified herbalist
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Investigation effect of oral chamomilla on sleep quality in elderly people in Isfahan: A randomized control trial by Abdullahzadeh M1, Matourypour P2, Naji SA1.(PubMed)
(2) The Effect of Chamomile Cream on Episiotomy Pain in Primiparous Women: A Randomized Clinical Trial by Aradmehr M1, Azhari S2, Ahmadi S3, Azmoude E4.(PubMed)
(3) Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats by Shinomiya K1, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C.(PubMed)
A quasi-experimental clinical trial, included 77 cases of elderly hospitalized in nursing homes, showed that oral administration of chamomile extract has sedative properties in sleep quality.
Sedation is a form of medicine in induced calm and sleep.
The herbal medicine is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
In support of the sedative effect, chamomile cream also is found to reduce episiotomy pain sedately in primiparous women, according to a triple-blind clinical trial performed on 114 eligible women at Ommolbanin Hospital in Mashhad, Iran in 2014.
Dr. McKay DL said, " Chamomile has moderate antioxidant and antimicrobial activities, and significant antiplatelet activity Animal model studies indicate potent antiinflammatory action, some antimutagenic and cholesterol-lowering activities, as well as antispasmodic and anxiolytic effects" and "(Unfortunately) However, human studies are limited, and clinical trials examining the purported sedative properties of chamomile tea are absent."
In fact, in the investigated hypnotic activities of chamomile and passiflora extracts using sleep-disturbed model rats, researchers at the Okayama University insisted, chamomile extract at a dose of 300 mg/kg exerted significantly decrease sleep latency.
The study also suggested chamomile extract is a herb having benzodiazepine-like hypnotic activity.
Taking all together, Chamomile may be helpful to aid calm and sleep through its sedative effects, but intake of the correct amount should only be given by qualified herbalist
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Investigation effect of oral chamomilla on sleep quality in elderly people in Isfahan: A randomized control trial by Abdullahzadeh M1, Matourypour P2, Naji SA1.(PubMed)
(2) The Effect of Chamomile Cream on Episiotomy Pain in Primiparous Women: A Randomized Clinical Trial by Aradmehr M1, Azhari S2, Ahmadi S3, Azmoude E4.(PubMed)
(3) Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats by Shinomiya K1, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C.(PubMed)
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