Chaste tree berry(Vitex agnus-castus), is found to process anti-estrogenic property in binding the estrogen receptors for a balance between the activities of estrogen receptor ERα or ERβ.
The herb is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
Anti estrogenic effects are an act of binding the estrogen receptor(ERα ) and/ERβ in inhibiting the excessive levels of estrogen circulating in the body.
According to the University of Alabama in Huntsville, in the study of the potential effect of estrogen mimics or anti-estrogens in phytochemicals of popular dietary herbal supplements, researchers found that almost all herbal supplements containing phytochemical components showed a capability in binding to the human estrogen receptor and exhibit selective estrogen receptor modulation, including chaste tree berry.
Casticin, a flavonoid isolated from Vitex rotundifolia, significantly expressed anti estrogenic effect in reduced the prolactin release stimulated by E2 in induced inhibition of ERα mRNA expression in a concentration-dependent manner, through its anti estrogenic effect.
In a hyperprolactinemia (MIHP) induced by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d) in SD rats, rat treated with casticin (10, 20, and 40 mg/kg, ip, for 7 d) reduced serum prolactin levels by 33.9%, 54.3%, and 64.7% and at(1 and 10 micromol/L) inhibited E2-induced pituitary cell proliferation by 27.7% and 42.1%, respectively through reduced levels of 17β-Estradiol (E2) significantly.
More importantly, oral administration of casticin, a flavonoid isolated from Vitex rotundifolia displayed an anti-estrogenic activity in decrease excessive levels of 17β-Estradiol (E2) significantly
Taking together, Chaste tree berry processes strong estrogenic and anti-estrogenic effects in binding estrogen receptor sites to preserve the balancing of hormone expression of estrogen through ER alpha and ERBeta inhibition and exhibition.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements by Powers CN1, Setzer WN1.(PubMed)
(2) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro by YE Q1, ZHANG QY, ZHENG CJ, WANG Y, QIN LP.(PubMed)
Tuesday, April 28, 2020
Monday, April 27, 2020
Dandelion (Taraxacum officinale) Processes a Strong Antifungal Activity
Fungal infection is a common disease caused by the overgrowth of fungus.
In other words, the immune system that protects the body against microorganisms has been overwhelming by the overgrowth of fungus.
Yeasts, molds, and mushrooms are types of fungi. The tiny microorganisms have cells with nuclear.
Most common fungal infections start from the lungs or the skin. Long-term use of antibiotics and people with the weakened immune system is susceptible to fungal infection, epidemiologically.
However, some researchers suggested that common risk factors for fungal infection also include pregnancy, diabetes mellitus, oral contraceptives, and inadequate therapy.
People with weakened immune systems such as cancer treatment, frequent use of antibiotics are associated to increase the risk of fungal infection.
Patients with diabetes are also more prone to fungal infections. Fungal infection associated with diabetes includes jock itch, athlete's foot,..... and ringworm.
Depending on the locations of infection, patients may experience symptoms of common peeling, cracking, scaling redness, blisters Itching,......, and burning sensation.
In women, signs of a yeast infection may include itching and swelling around the vagina. burning sensations or pain during urination or intercourse,........, and unusual vaginal discharge.
In men, signs of a yeast infection may include burning and itching around the head of the penis,
redness, and swelling, pain during urination or sex,..... small, rash-like bumps.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of fungal infectious diseases,
scientists examined the antifungal effects of novel peptide named ToAMP4 isolated from Taraxacum officinale Wigg. flowers by a combination of acetic acid extraction and different types of chromatography.
According to the tested differentiation of the biological activity of ToAMP4 produced in a prokaryotic expression system as a fusion protein with thioredoxin, the peptide ToAMP4 displayed broad-spectrum antifungal activity against phytopathogens.
Moreover, the two ToAMP4 also exerted significantly mediated inhibition properties, on the tested fungus
In other words, ToAMP4 processed anti-fungal infection depending on the types of fungus.
Taken altogether, dandelion may be considered a remedy for the prevention and treatment of fungal infection, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A novel cysteine-rich antifungal peptide ToAMP4 from Taraxacum officinale Wigg. flowers by Astafieva AA1, Rogozhin EA, Andreev YA, Odintsova TI, Kozlov SA, Grishin EV, Egorov TA. (PubMed)
In other words, the immune system that protects the body against microorganisms has been overwhelming by the overgrowth of fungus.
Yeasts, molds, and mushrooms are types of fungi. The tiny microorganisms have cells with nuclear.
Most common fungal infections start from the lungs or the skin. Long-term use of antibiotics and people with the weakened immune system is susceptible to fungal infection, epidemiologically.
However, some researchers suggested that common risk factors for fungal infection also include pregnancy, diabetes mellitus, oral contraceptives, and inadequate therapy.
People with weakened immune systems such as cancer treatment, frequent use of antibiotics are associated to increase the risk of fungal infection.
Patients with diabetes are also more prone to fungal infections. Fungal infection associated with diabetes includes jock itch, athlete's foot,..... and ringworm.
Depending on the locations of infection, patients may experience symptoms of common peeling, cracking, scaling redness, blisters Itching,......, and burning sensation.
In women, signs of a yeast infection may include itching and swelling around the vagina. burning sensations or pain during urination or intercourse,........, and unusual vaginal discharge.
In men, signs of a yeast infection may include burning and itching around the head of the penis,
redness, and swelling, pain during urination or sex,..... small, rash-like bumps.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of fungal infectious diseases,
scientists examined the antifungal effects of novel peptide named ToAMP4 isolated from Taraxacum officinale Wigg. flowers by a combination of acetic acid extraction and different types of chromatography.
According to the tested differentiation of the biological activity of ToAMP4 produced in a prokaryotic expression system as a fusion protein with thioredoxin, the peptide ToAMP4 displayed broad-spectrum antifungal activity against phytopathogens.
Moreover, the two ToAMP4 also exerted significantly mediated inhibition properties, on the tested fungus
In other words, ToAMP4 processed anti-fungal infection depending on the types of fungus.
Taken altogether, dandelion may be considered a remedy for the prevention and treatment of fungal infection, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A novel cysteine-rich antifungal peptide ToAMP4 from Taraxacum officinale Wigg. flowers by Astafieva AA1, Rogozhin EA, Andreev YA, Odintsova TI, Kozlov SA, Grishin EV, Egorov TA. (PubMed)
Sunday, April 26, 2020
Cinnamon, The Whole Herbal Medicine for Osteopenic Disease
Recent study suggested that cinnamon may be effective in prevented and treatment of osteopenic disease by inhibiting protein in transferred information of cytokine production involved cell survival.
Cinnamon is a spice derived from the inner bark of the tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, used in herbal and traditional medicine as anti-fungal and bacteria level, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.
The osteopenic disease is the early stage of osteoporosis involved the deletion of bone density in comparison to the healthy person.
According to the Keio University, cinnamon suppressed the osteoclastogenesis, protected bone density against erosion, interleukin-4 (IL-4), an anti-inflammatory cytokine, involved the production of white blood cell in inhibition of osteoclast differentiation through the expression of T cell of the immune system
Dr. Tsuji-Naito K. in the study of Interleukin-4 suggested that Cinnamomum zeylanicum (C. zeylanicum) exhibited strong inhibitory effects on osteoclastogenesis,......involved the regulation of white blood cells in osteoclastogenesis.
In a comprehensive systematic review of vitro and in-vivo, using databases from PubMed, Web of Science, SciVerse Scopus published before 31st December 2012, cinnamon has shown to express inhibitory effects on osteoclastogenesis with minimal toxic and adverse effects.
The effectiveness of cinnamon in reduced risk of Osteopenic diseases in inducing bone loss, including osteoporosis, bone metastasis, and rheumatoid arthritis may result in inhibition of inflammatory cytokines expression in the immune system. Use of cinnamon should be taken with care, as the herbal medicine has induced toxicity if overdoses.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1 by Takatsuna H1, Asagiri M, Kubota T, Oka K, Osada T, Sugiyama C, Saito H, Aoki K, Ohya K, Takayanagi H, Umezawa K.(PubMed)
(2) Aldehydic components of cinnamon bark extract suppresses RANKL-induced osteoclastogenesis through NFATc1 downregulation by Tsuji-Naito K1.(PubMed)
(3) Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum): a systematic review by Ranasinghe P1, Pigera S, Premakumara GA, Galappaththy P, Constantine GR, Katulanda P.(PubMed)
Cinnamon is a spice derived from the inner bark of the tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, used in herbal and traditional medicine as anti-fungal and bacteria level, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.
The osteopenic disease is the early stage of osteoporosis involved the deletion of bone density in comparison to the healthy person.
According to the Keio University, cinnamon suppressed the osteoclastogenesis, protected bone density against erosion, interleukin-4 (IL-4), an anti-inflammatory cytokine, involved the production of white blood cell in inhibition of osteoclast differentiation through the expression of T cell of the immune system
Dr. Tsuji-Naito K. in the study of Interleukin-4 suggested that Cinnamomum zeylanicum (C. zeylanicum) exhibited strong inhibitory effects on osteoclastogenesis,......involved the regulation of white blood cells in osteoclastogenesis.
In a comprehensive systematic review of vitro and in-vivo, using databases from PubMed, Web of Science, SciVerse Scopus published before 31st December 2012, cinnamon has shown to express inhibitory effects on osteoclastogenesis with minimal toxic and adverse effects.
The effectiveness of cinnamon in reduced risk of Osteopenic diseases in inducing bone loss, including osteoporosis, bone metastasis, and rheumatoid arthritis may result in inhibition of inflammatory cytokines expression in the immune system. Use of cinnamon should be taken with care, as the herbal medicine has induced toxicity if overdoses.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1 by Takatsuna H1, Asagiri M, Kubota T, Oka K, Osada T, Sugiyama C, Saito H, Aoki K, Ohya K, Takayanagi H, Umezawa K.(PubMed)
(2) Aldehydic components of cinnamon bark extract suppresses RANKL-induced osteoclastogenesis through NFATc1 downregulation by Tsuji-Naito K1.(PubMed)
(3) Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum): a systematic review by Ranasinghe P1, Pigera S, Premakumara GA, Galappaththy P, Constantine GR, Katulanda P.(PubMed)
Saturday, April 25, 2020
Herbal Butterbur, the Anti Asthma Functional Remedy
Scientists may have found a medicinal plant for the prevention and treatment of asthma with no side effects, according to studies.
Asthma is a chronic inflammatory disease, affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.
Most signs and symptoms of asthma are triggered by exposure to various irritants and substances such as allergens.
Researchers do not know why some people are prone to the substances that trigger the symptoms of asthma while others do not, even process the same health conditions in the same family.
According to the American Lung Association, there are many risk factors can trigger the onset of the diseases, including respiratory problems during infancy and childhood such as wheezing, children who experience viral respiratory infections, children who have an allergic condition, such as atopic dermatitis (eczema) or allergic rhinitis (hay fever), can also develop asthma.
The most preventable risk factors that cause the onset of adults asthma are smoking and obesity. Dr. Chen Y and colleagues at the University of Ottawa in the investigation of the risk asthma in among female Canadians wrote, "The prevalence of asthma was 10.4% for males and 11.2% for females aged 12-24 years. Among the subjects aged 25 years or more, the prevalence varied from 4.1% to 5.8% for men and from 4.9% to 6.4% for women".
And, "Female smokers demonstrated a 1.7-fold increase in the prevalence of asthma compared with female nonsmokers" and " the prevalence of asthma increased with increasing body mass index in females".
The results strongly suggested that if you are female and you don't want to have asthma, you must lose weight and quit smoking.
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
It has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin, and iso-S-petasin, etc.
With an aim to find a natural remedy for the treatment of asthma with no side effects, researchers at the examine the phytoceuticals (non-nutritional but beneficial plant chemicals) used as a pharmacotherapy for asthma and chronic obstructive pulmonary disease (COPD).
Recently, herbal butterbur has been found to benefit and improve treatments for lung disease, particularly in that of airway inflammatory disease, including asthma and chronic obstructive pulmonary disease (COPD.
Ovalbumin (OVA) immunized BALB/c mice selected to the experiment were given intranasally together with antigen challenge in the murine model of allergic airway disease (asthma)
The analysis of the inflammatory and immune parameters in the lung suggested FET treated mice exerted a significant effect in inhibiting the allergic response.
Furthermore, PET also inhibited airway hyperresponsiveness (AHR) and eosinophil recruitment into the bronchoalveolar lavage (BAL) fluid upon allergen challenge observed by a medical procedure in which a bronchoscope is passed through the mouth or nose into the lungs but had no effect in the saline control mice.
According to the reading eosinophilic activation marker, PET at a concentration of 100 microg strongly lowered the levels of serum eosinophil peroxidase (EPO).
These results suggested inflammation, eosinophil recruitment, and mucus hyperproduction are significantly decreased in the lung with the administration of 100 microg PET.
Moreover, at the concentration of 30 microg PET, researchers found that airway hyperresponsiveness (AHR) and inflammation of treated mice associated with the production of inflammatory cytokines reduced (IL-4, IL-5) and RANTES production involved the mediation of acute and chronic inflammation are strongly reduced without affecting the expression of IgE and eotaxin serum levels.
Where Eotaxin is a small protein produced in the lungs of asthmatic patients.
The finding indicated PET inhibited the expression of asthma through decreasing the airway hyperresponsiveness, airway inflammation, eosinophil recruitment, and mucus hyperproduction of the asthmatic mice, in a dose-dependent manner.
Taken altogether, herbal butterbur may be considered a natural remedy for the prevention and combined with conventional medicine for the treatment of asthma and COPD with no side effects, pending to the confirmation of the large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.References
(1) Phytoceuticals: the new 'physic garden' for asthma and chronic obstructive pulmonary disease.
Grandhi S, Donnelly LE, Rogers DF.(PubMed)
(2) Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation and airway hyperreactivity in mice by Brattström A1, Schapowal A, Maillet I, Schnyder B, Ryffel B, Moser R.(PubMed)
(3) Increased effects of smoking and obesity on asthma among female Canadians: the National Population Health Survey, 1994-1995 by Chen Y1, Dales R, Krewski D, Breithaupt K. (PubMed)
Asthma is a chronic inflammatory disease, affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.
Most signs and symptoms of asthma are triggered by exposure to various irritants and substances such as allergens.
Researchers do not know why some people are prone to the substances that trigger the symptoms of asthma while others do not, even process the same health conditions in the same family.
According to the American Lung Association, there are many risk factors can trigger the onset of the diseases, including respiratory problems during infancy and childhood such as wheezing, children who experience viral respiratory infections, children who have an allergic condition, such as atopic dermatitis (eczema) or allergic rhinitis (hay fever), can also develop asthma.
The most preventable risk factors that cause the onset of adults asthma are smoking and obesity. Dr. Chen Y and colleagues at the University of Ottawa in the investigation of the risk asthma in among female Canadians wrote, "The prevalence of asthma was 10.4% for males and 11.2% for females aged 12-24 years. Among the subjects aged 25 years or more, the prevalence varied from 4.1% to 5.8% for men and from 4.9% to 6.4% for women".
And, "Female smokers demonstrated a 1.7-fold increase in the prevalence of asthma compared with female nonsmokers" and " the prevalence of asthma increased with increasing body mass index in females".
The results strongly suggested that if you are female and you don't want to have asthma, you must lose weight and quit smoking.
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
It has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin, and iso-S-petasin, etc.
With an aim to find a natural remedy for the treatment of asthma with no side effects, researchers at the examine the phytoceuticals (non-nutritional but beneficial plant chemicals) used as a pharmacotherapy for asthma and chronic obstructive pulmonary disease (COPD).
Recently, herbal butterbur has been found to benefit and improve treatments for lung disease, particularly in that of airway inflammatory disease, including asthma and chronic obstructive pulmonary disease (COPD.
Ovalbumin (OVA) immunized BALB/c mice selected to the experiment were given intranasally together with antigen challenge in the murine model of allergic airway disease (asthma)
The analysis of the inflammatory and immune parameters in the lung suggested FET treated mice exerted a significant effect in inhibiting the allergic response.
Furthermore, PET also inhibited airway hyperresponsiveness (AHR) and eosinophil recruitment into the bronchoalveolar lavage (BAL) fluid upon allergen challenge observed by a medical procedure in which a bronchoscope is passed through the mouth or nose into the lungs but had no effect in the saline control mice.
According to the reading eosinophilic activation marker, PET at a concentration of 100 microg strongly lowered the levels of serum eosinophil peroxidase (EPO).
These results suggested inflammation, eosinophil recruitment, and mucus hyperproduction are significantly decreased in the lung with the administration of 100 microg PET.
Moreover, at the concentration of 30 microg PET, researchers found that airway hyperresponsiveness (AHR) and inflammation of treated mice associated with the production of inflammatory cytokines reduced (IL-4, IL-5) and RANTES production involved the mediation of acute and chronic inflammation are strongly reduced without affecting the expression of IgE and eotaxin serum levels.
Where Eotaxin is a small protein produced in the lungs of asthmatic patients.
The finding indicated PET inhibited the expression of asthma through decreasing the airway hyperresponsiveness, airway inflammation, eosinophil recruitment, and mucus hyperproduction of the asthmatic mice, in a dose-dependent manner.
Taken altogether, herbal butterbur may be considered a natural remedy for the prevention and combined with conventional medicine for the treatment of asthma and COPD with no side effects, pending to the confirmation of the large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.References
(1) Phytoceuticals: the new 'physic garden' for asthma and chronic obstructive pulmonary disease.
Grandhi S, Donnelly LE, Rogers DF.(PubMed)
(2) Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation and airway hyperreactivity in mice by Brattström A1, Schapowal A, Maillet I, Schnyder B, Ryffel B, Moser R.(PubMed)
(3) Increased effects of smoking and obesity on asthma among female Canadians: the National Population Health Survey, 1994-1995 by Chen Y1, Dales R, Krewski D, Breithaupt K. (PubMed)
Friday, April 24, 2020
Herbal Ashwagandha Improves Fertility in Men
Infertility is a reproductive disease characterized by the failure to produce a pregnancy after 12 regular unprotected sexual intercourse, including pregnancy that can not be carried to term.
Infertility is very common in the US, approximately 10% of women or 6.1 million, ages 15-44 have difficulty getting pregnant or staying pregnant, according to the Centers for Disease Control and Prevention (CDC).
Believe it or not, only a very small number of such groups are seeking help from the professionals.
In men, age, pesticide and chemical exposure, drug use, radiation, pollution, cigarette or marijuana smoke, heavy alcohol consumption may be some risk factors for the onset of infertility.
In fact, some unfertilized women and men sometimes ago are fertile. However, here are some reasons that have found to increase the risk of infertility in the Western world, including
* Persuade a personal career, before having children.
*Try to be financial stability before having children.
* Too young to be a parent, raising a child needs efforts, time and money.
* Enjoy the couple childless years before committing.
Some researchers suggested that the widespread obesity in North America may be the major factor correlated to the increased infertile rate over the past few decades.
Dr. Nicole O. Palmer the lead scientist in the concern of obesity in the risk of men infertility, wrote, "Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility".
And, "Recent data has shown that male obesity also impairs offspring metabolic and reproductive health suggesting that paternal health cues are transmitted to the next generation with the mediator mostly likely occurring via the sperm.".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of infertility, researchers examined beneficial effects induced by oral intake of the Withania sominifera (Ashwagandha) on semen quality of infertile men.
Based on the tested analysis, oral intake of Ashwagandha roots only improved sperm count and motility, and regulate reproductive hormone levels. but also inhibited the lipid peroxidation associated with the risk of infertility.
In a molecular perspective, oral intake of Ashwagandha roots inhibited the mitigation of oxidative stress and pathways involved in hormonal imbalance by enhancing the interaction of different endocrine glands to improve male fertility.
More precisely, Ashwagandha roots improved men's fertility by mitigating risk factor-that cause the onset of men's infertility.
In stress-induced male infertility on selected normozoospermic but infertile individuals (N = 60) that: divided into normozoospermic heavy smokers (N = 20), normozoospermic under psychological stress (N = 20) and normozoospermic with infertility of unknown etiology (N = 20).
Compared to Normozoospermic fertile men (N = 60), root powder of W. somnifera at a rate of 5 g/day for 3 months showed a strong effect in the treatment of stress-related infertility by improving the level of anti-oxidants and overall semen quality.
Root powder of W. somnifera treatment also resulted in pregnancy in the partners of 14% of the patients.
Taken altogether, Ashwagandha may be considered a functional herb for the treatment of male infertility, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Role of Withania somnifera (Ashwagandha) in the management of male infertility by Sengupta P1, Agarwal A2, Pogrebetskaya M3, Roychoudhury S4, Durairajanayagam D5, Henkel R. (PubMed)
(2) Withania somnifera Improves Semen Quality in Stress-Related Male Fertility by Mahdi AA1, Shukla KK, Ahmad MK, Rajender S, Shankhwar SN, Singh V, Dalela D. (PubMed)
(3) Impact of obesity on male fertility, sperm function and molecular composition by Nicole O. Palmer, Hassan W. Bakos, Tod Fullston, and Michelle Lane. (PMC)
Infertility is very common in the US, approximately 10% of women or 6.1 million, ages 15-44 have difficulty getting pregnant or staying pregnant, according to the Centers for Disease Control and Prevention (CDC).
Believe it or not, only a very small number of such groups are seeking help from the professionals.
In men, age, pesticide and chemical exposure, drug use, radiation, pollution, cigarette or marijuana smoke, heavy alcohol consumption may be some risk factors for the onset of infertility.
In fact, some unfertilized women and men sometimes ago are fertile. However, here are some reasons that have found to increase the risk of infertility in the Western world, including
* Persuade a personal career, before having children.
*Try to be financial stability before having children.
* Too young to be a parent, raising a child needs efforts, time and money.
* Enjoy the couple childless years before committing.
Some researchers suggested that the widespread obesity in North America may be the major factor correlated to the increased infertile rate over the past few decades.
Dr. Nicole O. Palmer the lead scientist in the concern of obesity in the risk of men infertility, wrote, "Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility".
And, "Recent data has shown that male obesity also impairs offspring metabolic and reproductive health suggesting that paternal health cues are transmitted to the next generation with the mediator mostly likely occurring via the sperm.".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of infertility, researchers examined beneficial effects induced by oral intake of the Withania sominifera (Ashwagandha) on semen quality of infertile men.
Based on the tested analysis, oral intake of Ashwagandha roots only improved sperm count and motility, and regulate reproductive hormone levels. but also inhibited the lipid peroxidation associated with the risk of infertility.
In a molecular perspective, oral intake of Ashwagandha roots inhibited the mitigation of oxidative stress and pathways involved in hormonal imbalance by enhancing the interaction of different endocrine glands to improve male fertility.
More precisely, Ashwagandha roots improved men's fertility by mitigating risk factor-that cause the onset of men's infertility.
In stress-induced male infertility on selected normozoospermic but infertile individuals (N = 60) that: divided into normozoospermic heavy smokers (N = 20), normozoospermic under psychological stress (N = 20) and normozoospermic with infertility of unknown etiology (N = 20).
Compared to Normozoospermic fertile men (N = 60), root powder of W. somnifera at a rate of 5 g/day for 3 months showed a strong effect in the treatment of stress-related infertility by improving the level of anti-oxidants and overall semen quality.
Root powder of W. somnifera treatment also resulted in pregnancy in the partners of 14% of the patients.
Taken altogether, Ashwagandha may be considered a functional herb for the treatment of male infertility, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Role of Withania somnifera (Ashwagandha) in the management of male infertility by Sengupta P1, Agarwal A2, Pogrebetskaya M3, Roychoudhury S4, Durairajanayagam D5, Henkel R. (PubMed)
(2) Withania somnifera Improves Semen Quality in Stress-Related Male Fertility by Mahdi AA1, Shukla KK, Ahmad MK, Rajender S, Shankhwar SN, Singh V, Dalela D. (PubMed)
(3) Impact of obesity on male fertility, sperm function and molecular composition by Nicole O. Palmer, Hassan W. Bakos, Tod Fullston, and Michelle Lane. (PMC)
Thursday, April 23, 2020
Dandelion (Taraxacum officinale), the Best Antioxidant Functional Herbal Medicine
Antioxidants are stable atoms that inhibit oxidation caused by free radicals.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.
Believe it or not, free radicals also play a critical role in maintaining a certain body function. The Journal of Physiology showed that free radicals act as signal substances that cause the heart to beat with the correct force.
In healthy individuals, antioxidant enzymes produced by the liver are good enough to balance the free radical produced by the cell metabolism and external sources such as the air we breathe and the food we eat.
However, in people with a weakened immune system such as infants, children, and the elderly, dietary sources from supplements, fruits and vegetables may be needed.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world.
The herbal medicine has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the treatment of chronic inflammatory diseases, scientists examined in vitro and in vivo the antioxidant effects of 70% ethanol-water (v/v) leaf and root extracts of T. officinale (TOL and TOR, respectively).
The study included organ homogenate samples from Nω-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats, treated by leaf extracts of TOL (500 mg/kg/day) and TOR (500 mg/kg/day) for 21 days.
Based on the results from the experiment, the antioxidant contents of ) polyphenol (4.35 ± 0.15 compared to 1.14 ± 0.01) and flavonoid (23.17 ± 0.14 compared to 3 ± 0.05) of TOL are significantly higher compared to TOR.
TOL exerted a significantly higher free radical scavenging activity (EC50 0.37 compared to 1.34 mg/mL) and total antioxidant capacities (82.56% compared to 61.54% ABTS, and 156 ± 5.28 compared to 40 ± 0.31 FRAP) compared to TOR.
Furthermore, both extracts inhibited the oxidative stress marker MDA levels and increased the total antioxidant capacity (TAC) without inducing toxicity with LD50 > 5000 mg/kg).
Collectively, T. officinale leaf extract possesses significant anti-oxidant effects that conferred significant in vivo antioxidant protection against free radical-mediated oxidative stress in L-NAME-induced hypertensive rats.
Taken altogether, dandelion may be considered a remedy for enhancing the antioxidant capacity against oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) In Vitro and In Vivo Antioxidant Properties of Taraxacum officinale in Nω-Nitro-l-Arginine Methyl Ester (L-NAME)-Induced Hypertensive Rats by Aremu OO1, Oyedeji AO2, Oyedeji OO3, Nkeh-Chungag BN4, Rusike CRS, (PubMed)
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.
Believe it or not, free radicals also play a critical role in maintaining a certain body function. The Journal of Physiology showed that free radicals act as signal substances that cause the heart to beat with the correct force.
In healthy individuals, antioxidant enzymes produced by the liver are good enough to balance the free radical produced by the cell metabolism and external sources such as the air we breathe and the food we eat.
However, in people with a weakened immune system such as infants, children, and the elderly, dietary sources from supplements, fruits and vegetables may be needed.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world.
The herbal medicine has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the treatment of chronic inflammatory diseases, scientists examined in vitro and in vivo the antioxidant effects of 70% ethanol-water (v/v) leaf and root extracts of T. officinale (TOL and TOR, respectively).
The study included organ homogenate samples from Nω-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats, treated by leaf extracts of TOL (500 mg/kg/day) and TOR (500 mg/kg/day) for 21 days.
Based on the results from the experiment, the antioxidant contents of ) polyphenol (4.35 ± 0.15 compared to 1.14 ± 0.01) and flavonoid (23.17 ± 0.14 compared to 3 ± 0.05) of TOL are significantly higher compared to TOR.
TOL exerted a significantly higher free radical scavenging activity (EC50 0.37 compared to 1.34 mg/mL) and total antioxidant capacities (82.56% compared to 61.54% ABTS, and 156 ± 5.28 compared to 40 ± 0.31 FRAP) compared to TOR.
Furthermore, both extracts inhibited the oxidative stress marker MDA levels and increased the total antioxidant capacity (TAC) without inducing toxicity with LD50 > 5000 mg/kg).
Collectively, T. officinale leaf extract possesses significant anti-oxidant effects that conferred significant in vivo antioxidant protection against free radical-mediated oxidative stress in L-NAME-induced hypertensive rats.
Taken altogether, dandelion may be considered a remedy for enhancing the antioxidant capacity against oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) In Vitro and In Vivo Antioxidant Properties of Taraxacum officinale in Nω-Nitro-l-Arginine Methyl Ester (L-NAME)-Induced Hypertensive Rats by Aremu OO1, Oyedeji AO2, Oyedeji OO3, Nkeh-Chungag BN4, Rusike CRS, (PubMed)
Wednesday, April 22, 2020
Herbal Cleaver(Galium aparine), inhibits the Melanoma Cell Metastasis in Vitro
Skin melanoma is a skin cancer characterized by the alternation of the pigment-containing cells known as melanocytes. However, in rare cases, melanoma can also occur in the mouth, intestines, or eye.
Most cases of melanoma start in melanocytes on skin before spreading to the nearby tissue. In the advanced stage, the cancer cells can also travel a distance away from the originated site to infect other tissues and organs, leading to secondary metastasis, through the circulation of blood and fluids.
The most common sites of melanoma metastasis are the lung and breast.
The most common symptoms are visible by examing the change of skin, including the sores that can not heal itself, redness or swelling, persistent itching, tenderness and pain and particular, change of skin color, and bleeding off of a mole compared to the normal moles.
The 4 most common types of skin melanoma include
* Superficial spreading melanoma, the type of cancer has a tendency to spread grow outward and spread across the surface of the skin, accounted for 70% of all melanoma skin cancer.
* Nodular melanoma normally grows down into the skin and has a tendency to spread more quickly than other types of melanoma skin cancer.
* Lentigo malignant melanoma, most common in the older population, making up approximately 15% of all melanoma skin cancer.
* Acral lentiginous melanoma, most common in people with darker skin. Cancer first moves outward before spreading deeper into the skin.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 96,480 new melanomas will be diagnosed (about 57,220 in men and 39,260 in women) in the US. The condition also causes the death of 4,740 men and 2,490 women.
Believe it or not. most cases of melanoma are found in older adults. The average age diagnosed with melanoma is 63.
Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
On finding a potential compound for the treatment of skin diseases, researchers investigated the Gallic acid (GA) found in herbal Cleaver in the inhibition of the growth of human cancer cells in vitro and in vivo.
GA decreases the expression of MMPs MMPs mRNA levels in A375.S2 human melanoma cells in stimulating the cancer cell metastasis.
Furthermore, GA processed antimetastatic potential by decreasing the invasiveness of cancer cells.
Moreover, this action of GA was involved in the Ras, p-ERK signaling pathways with function to communicate a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell to induce the inhibition of MMP-2 associated with cancer spreading in A375.S2 human melanoma cells.
Based on the findings, researchers said, " These data, therefore, provide evidence for the role of GA as a potential cancer chemotherapeutic agent, which can markedly inhibit the invasive capacity of melanoma cells".
o
Taken altogether, Comfrey may be considered a remedy to inhibit cancer call spreading, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Gallic acid inhibits the migration and invasion of A375.S2 human melanoma cells through the inhibition of matrix metalloproteinase-2 and Ras by Lo C1, Lai TY, Yang JS, Yang JH, Ma YS, Weng SW, Lin HY, Chen HY, Lin JG, Chung JG. (PubMed)
Most cases of melanoma start in melanocytes on skin before spreading to the nearby tissue. In the advanced stage, the cancer cells can also travel a distance away from the originated site to infect other tissues and organs, leading to secondary metastasis, through the circulation of blood and fluids.
The most common sites of melanoma metastasis are the lung and breast.
The most common symptoms are visible by examing the change of skin, including the sores that can not heal itself, redness or swelling, persistent itching, tenderness and pain and particular, change of skin color, and bleeding off of a mole compared to the normal moles.
The 4 most common types of skin melanoma include
* Superficial spreading melanoma, the type of cancer has a tendency to spread grow outward and spread across the surface of the skin, accounted for 70% of all melanoma skin cancer.
* Nodular melanoma normally grows down into the skin and has a tendency to spread more quickly than other types of melanoma skin cancer.
* Lentigo malignant melanoma, most common in the older population, making up approximately 15% of all melanoma skin cancer.
* Acral lentiginous melanoma, most common in people with darker skin. Cancer first moves outward before spreading deeper into the skin.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 96,480 new melanomas will be diagnosed (about 57,220 in men and 39,260 in women) in the US. The condition also causes the death of 4,740 men and 2,490 women.
Believe it or not. most cases of melanoma are found in older adults. The average age diagnosed with melanoma is 63.
Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
On finding a potential compound for the treatment of skin diseases, researchers investigated the Gallic acid (GA) found in herbal Cleaver in the inhibition of the growth of human cancer cells in vitro and in vivo.
GA decreases the expression of MMPs MMPs mRNA levels in A375.S2 human melanoma cells in stimulating the cancer cell metastasis.
Furthermore, GA processed antimetastatic potential by decreasing the invasiveness of cancer cells.
Moreover, this action of GA was involved in the Ras, p-ERK signaling pathways with function to communicate a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell to induce the inhibition of MMP-2 associated with cancer spreading in A375.S2 human melanoma cells.
Based on the findings, researchers said, " These data, therefore, provide evidence for the role of GA as a potential cancer chemotherapeutic agent, which can markedly inhibit the invasive capacity of melanoma cells".
o
Taken altogether, Comfrey may be considered a remedy to inhibit cancer call spreading, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Gallic acid inhibits the migration and invasion of A375.S2 human melanoma cells through the inhibition of matrix metalloproteinase-2 and Ras by Lo C1, Lai TY, Yang JS, Yang JH, Ma YS, Weng SW, Lin HY, Chen HY, Lin JG, Chung JG. (PubMed)
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