Cinnamon, The Whole Herbal Medicine for Osteopenic Disease

Recent study suggested that cinnamon may be effective in prevented and treatment of osteopenic disease by inhibiting protein in transferred information of cytokine production involved cell survival.

Cinnamon is a spice derived from the inner bark of the tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, used in herbal and traditional medicine as anti-fungal and bacteria level, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.

The osteopenic disease is the early stage of osteoporosis involved the deletion of bone density in comparison to the healthy person.

According to the Keio University, cinnamon suppressed the osteoclastogenesis, protected bone density against erosion, interleukin-4 (IL-4), an anti-inflammatory cytokine, involved the production of white blood cell in inhibition of osteoclast differentiation through the expression of T cell of the immune system

Dr. Tsuji-Naito K. in the study of Interleukin-4 suggested that Cinnamomum zeylanicum (C. zeylanicum) exhibited strong inhibitory effects on osteoclastogenesis,......involved the regulation of white blood cells in osteoclastogenesis.



In a comprehensive systematic review of vitro and in-vivo, using databases from PubMed, Web of Science, SciVerse Scopus published before 31st December 2012, cinnamon has shown to express inhibitory effects on osteoclastogenesis with minimal toxic and adverse effects.

The effectiveness of cinnamon in reduced risk of Osteopenic diseases in inducing bone loss, including osteoporosis, bone metastasis, and rheumatoid arthritis may result in inhibition of inflammatory cytokines expression in the immune system. Use of cinnamon should be taken with care, as the herbal medicine has induced toxicity if overdoses.


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Sources
(1) Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1 by Takatsuna H1, Asagiri M, Kubota T, Oka K, Osada T, Sugiyama C, Saito H, Aoki K, Ohya K, Takayanagi H, Umezawa K.(PubMed)
(2) Aldehydic components of cinnamon bark extract suppresses RANKL-induced osteoclastogenesis through NFATc1 downregulation by Tsuji-Naito K1.(PubMed)
(3) Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum): a systematic review by Ranasinghe P1, Pigera S, Premakumara GA, Galappaththy P, Constantine GR, Katulanda P.(PubMed)