Retinal ganglion cell (RGC) is a type of neuron in the innermost cellular layer of the retina of the eye. The neurons receive visual information and pass them to the brain.
Believe or not, the neurons also extract different aspects of the image before passing them to the brain.
According to the biological information from an animal model, retinal ganglion cells distributed evenly across the retina, with the density ranges from ∼3000 cells per mm2 to ∼600 cells per mm2 depending on the areas of distribution.
Certain neurodegenerative diseases have been found to induce the gradual loss of retinal ganglion cells. Alzheimer's' disease and disease associated with multiple system atrophy the loss of retinal ganglion cells showed a pattern resembling glaucoma.
However, in patients with Parkinson’s disease (PD) and Huntington’s disease, the loss of RGCs are found to resemble that of mitochondrial optic neuropathies.
Any structural damage of the retinal nerve fiber layer and optic nerve head, or functional damage can affect the RGC integrity.
Symptoms of retinal ganglion cell (RGC) loss is depended on the level of damage of the retinal nerve fiber layer and optic nerve head in the retina. Symptoms can be severe eye pain accompanied by nausea and vomiting, visual disturbance, blurred vision in patients with glaucoma.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the urgency on finding a plant-based compound for the treatment of retinal damage, researchers evaluated the protective effects of a Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) on retinal ganglion cells (RGCs) against damage.
In vitro, retinal ganglion cells damage induced by free radical activation by injection of 3-(4-morpholinyl) sydnonimine hydrochloride (SIN-1, a peroxynitrite donor) and in vivo, N-methyl-D-aspartic acid (NMDA)-induced retinal damage in mice, researchers showed that VMA and all three anthocyanidins significantly inhibited SIN-1-induced neurotoxicity and radical activation in RGC-5 associated with the initiation of damage of the retinal ganglion cells.
Lipid peroxidation in mouse forebrain homogenates involved the retinal damage was also reduced by all tested compounds in concentration and dose-dependent manner.
Furthermore, intravitreous injected VMA significantly inhibited the NMDA-induced morphological retinal damage and an increase in apoptosis of DNA fragments in the ganglion cell layer.
Based on the findings, researchers suggested that bioactive compounds isolated bilberry process neuroprotective effects through antioxidative properties in vitro and in vivo models of retinal diseases.
In order to obtain more information about bilberry protective property against the damage of retinal ganglion cells, scientists analyzed the bilberry extract anthocyanins on retinal ganglion cell (RGC) survival after optic nerve crush.
C57BL/6J mice selected for the study were administrated orally with anthocyanins in bilberry extract (100 mg/kg/day or 500 mg/kg/day).
According to the tested assays, all doses of anthocyanins in bilberry extract exhibited increased significantly levels of Grp78 and Grp94 associated with endoplasmic reticulum integrity and stress-induced autophagy in mice detected in the inner nuclear layer and ganglion cell layer of the retina, surrounding the RGCs.
Gene expression of Chop, Bax, and Atf4 increased associated with cellular stress, and the mediation of apoptosis in mice after optic nerve crush was also decreased significantly after oral bilberry extract administration.
In other words, retinal ganglion cell (RGC) survival was increased substantially after injecting anthocyanins in bilberry extract.
Dr. Nakamura O, the lead scientist after taking into account co and confounders wrote, "bilberry extract has a potential role in neuroprotective treatments for retinal injuries, such as those which occur in glaucoma".
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the protection of retinal damage against retinal diseases, particularly in retinal degeneration, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry extract administration prevents retinal ganglion cell death in mice via the regulation of chaperone molecules under conditions of endoplasmic reticulum stress by Nakamura O1, Moritoh S1,2, Sato K1,3, Maekawa S1, Murayama N1, Himori N1, Omodaka K1,3, Sogon T4, Nakazawa T. (PubMed)
(2) Bilberry and its main constituents have neuroprotective effects against retinalneuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H.(PubMed)
Tuesday, May 19, 2020
Monday, May 18, 2020
Cranberry, the Potent Free Radical Scavenger
Free radicals are highly reactive atoms associated with an unpaired electron in the outermost ring produced internally by our body cell metabolism and externally by the environmental factors, including the air which we breathe and the food we eat.
In other words, any chemicals compounds or molecules which process oxygen atom can be free radicals after chemical interaction.
Believe it or not, free radical in moderate amounts is important for our body functions such as NO cardio-vessel relaxation. However, in high levels, free radicals have been found epidemiologically to damage the lipid, and protein and induce the alternation of healthy cell DNA.
Out of all damages caused by overexpression of free radicals, some researchers suggested that lipid peroxidation induced by free radicals has a strong implication in the pathogenesis of various disorders and diseases, including free radical-mediated chain reaction, enzyme-mediated oxidation, and nonradical, non-enzymatic oxidation.
This chain of reaction can not be stopped until the electrons on the outermost ring of free radicals are paired or inhibited by antioxidants.
Free radical scavengers are antioxidants that process a specific function to prevent the forming of free radicals by removing them before they can damage vital components of the cell.
Dr. Slemmer JE, the lead scientist in the examination of free radical scavengers for the treatment of stroke wrote, "The overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a common underlying mechanism of many neuropathologies, as they have been shown to damage various cellular components, including proteins, lipids, and DNA".
And "several acute and chronic pharmacological therapies that have been extensively studied in order to reduce ROS/RNS loads in cells and the subsequent oxidative stress, so-called "free-radical scavengers".
These results strongly suggested that antioxidants with free radical scavenging activity protect the body against the damage of various cellular components, including proteins, lipids, and DNA alternation in the initiation of diseases.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of diseases associated with oxidative stress, researchers examined the cranberry antioxidative and protective effects of cranberry flavonoids in free radical-generating systems on mitochondrial ultrastructure.
In radical-generating systems, cranberry flavonoids effectively inhibit the generation of free radical nitric oxide (IC50 = 4.4 ± 0.4 µg/ml), superoxide anion radicals (IC50 = 2.8 ± 0.3 µg/ml) and hydroxyl radicals (IC50 = 53 ± 4 µg/ml).
1,1-diphenyl-2-picrylhydrazyl radicals (DPPH) were scavenged at the concentration of 2.2 ± 0.3 µg/ml with the IC50.
Furthermore, cranberry flavonoids exerted the antioxidant and free radical scavenging activity against lipid peroxidation in liposomal membranes and glutathione oxidation in erythrocytes induced by UV irradiation or organic hydroperoxides.
Moreover, the phytochemical compound also decreased the rigidity of the outer leaflet of the liposomal membranes.
In the liver, cranberry flavonoids also displayed hepatoprotective potential by preventing rat liver mitochondrial damage.
Collectively, researchers said, "The mitochondria-addressed effects of flavonoids might be related both to radical-scavenging properties and modulation of various mitochondrial events".
Taken altogether, cranberry may be considered a free radical scavenging remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry flavonoids prevent toxic rat liver mitochondrial damage in vivo and scavenge free radicals in vitro by Lapshina EA1, Zamaraeva M2, Cheshchevik VT1, Olchowik-Grabarek E2, Sekowski S2, Zukowska I2, Golovach NG1, Burd VN1, Zavodnik IB. (PubMed)
(2) The natural food colorant Peonidin from cranberries as a potential radicalscavenger - A DFT based mechanistic analysis by Rajan VK1, Hasna CK1, Muraleedharan K2. (PubMed)
In other words, any chemicals compounds or molecules which process oxygen atom can be free radicals after chemical interaction.
Believe it or not, free radical in moderate amounts is important for our body functions such as NO cardio-vessel relaxation. However, in high levels, free radicals have been found epidemiologically to damage the lipid, and protein and induce the alternation of healthy cell DNA.
Out of all damages caused by overexpression of free radicals, some researchers suggested that lipid peroxidation induced by free radicals has a strong implication in the pathogenesis of various disorders and diseases, including free radical-mediated chain reaction, enzyme-mediated oxidation, and nonradical, non-enzymatic oxidation.
This chain of reaction can not be stopped until the electrons on the outermost ring of free radicals are paired or inhibited by antioxidants.
Free radical scavengers are antioxidants that process a specific function to prevent the forming of free radicals by removing them before they can damage vital components of the cell.
Dr. Slemmer JE, the lead scientist in the examination of free radical scavengers for the treatment of stroke wrote, "The overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a common underlying mechanism of many neuropathologies, as they have been shown to damage various cellular components, including proteins, lipids, and DNA".
And "several acute and chronic pharmacological therapies that have been extensively studied in order to reduce ROS/RNS loads in cells and the subsequent oxidative stress, so-called "free-radical scavengers".
These results strongly suggested that antioxidants with free radical scavenging activity protect the body against the damage of various cellular components, including proteins, lipids, and DNA alternation in the initiation of diseases.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of diseases associated with oxidative stress, researchers examined the cranberry antioxidative and protective effects of cranberry flavonoids in free radical-generating systems on mitochondrial ultrastructure.
In radical-generating systems, cranberry flavonoids effectively inhibit the generation of free radical nitric oxide (IC50 = 4.4 ± 0.4 µg/ml), superoxide anion radicals (IC50 = 2.8 ± 0.3 µg/ml) and hydroxyl radicals (IC50 = 53 ± 4 µg/ml).
1,1-diphenyl-2-picrylhydrazyl radicals (DPPH) were scavenged at the concentration of 2.2 ± 0.3 µg/ml with the IC50.
Furthermore, cranberry flavonoids exerted the antioxidant and free radical scavenging activity against lipid peroxidation in liposomal membranes and glutathione oxidation in erythrocytes induced by UV irradiation or organic hydroperoxides.
Moreover, the phytochemical compound also decreased the rigidity of the outer leaflet of the liposomal membranes.
In the liver, cranberry flavonoids also displayed hepatoprotective potential by preventing rat liver mitochondrial damage.
Collectively, researchers said, "The mitochondria-addressed effects of flavonoids might be related both to radical-scavenging properties and modulation of various mitochondrial events".
Taken altogether, cranberry may be considered a free radical scavenging remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry flavonoids prevent toxic rat liver mitochondrial damage in vivo and scavenge free radicals in vitro by Lapshina EA1, Zamaraeva M2, Cheshchevik VT1, Olchowik-Grabarek E2, Sekowski S2, Zukowska I2, Golovach NG1, Burd VN1, Zavodnik IB. (PubMed)
(2) The natural food colorant Peonidin from cranberries as a potential radicalscavenger - A DFT based mechanistic analysis by Rajan VK1, Hasna CK1, Muraleedharan K2. (PubMed)
Sunday, May 17, 2020
Bromelain, the Natural Prevention and Treatment of Chronic Rhinosinusitis (RS) With No Side Effects
Rhinosinusitis (RS) is a condition associated with the inflammation of the sinuses and nasal cavity.
Chronic Rhinosinusitis (CRS) is an inflammation of the sinuses and nasal cavity that last more than 12 weeks.
According to statistics, the prevalence of CRS in Korea, Europe, and the US is approximately 7%, 10%, and 12%, respectively.
The exact causes of CRS are not identified. However, some researches suggested that infection that does not heal itself due to the inability of the immune system to destroy all the infectious pathogens in the acute phase of infection may play a critical role to the onset of the condition.
Symptoms of CRS are totally depending on the state of severity. Some patients may experience symptoms of facial pressure or pain, post-nasal drainage, nasal blockage, anosmia or hyposmia, or fatigue.
Conventionally, medications used for the treatment of CRS are focusing on reducing symptoms and improved quality of life, inclduing prescribed antibiotics in case of bacterial infection.
If all medicines fail, surgery may be necessary.
Out of many risk factors associated with the onset of CRS, some researchers suggested that cigarette smoking may have a strong and negative impact on the syndrome.
Dr. Douglas D. Reh, the lead scientist wrote, " Environmental factors such as inhaled pollutants like cigarette smoke may play a significant role in diseases of the upper airway including chronic rhinosinusitis (CRS)".
And, "There is clear evidence in the literature that cigarette smoke, either through active smoking or passive exposure to SHS, contributes to CRS".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to discover a potential ingredient for the treatment of chronic rhinosinusitis, researchers investigated the penetration of bromelain into sinonasal mucosa in patients with chronic rhinosinusitis (CRS), compared to the control group.
40 participants with CRS were divided into 2 groups equally either treated by bromelain derived from pineapple (Ananas comosus) or control.
Bromelain 500 mg tablet twice daily administered for 30 days in the treatment group displayed a significant effect in reduced inflammation in patients with CRS compared to control.
In other words, bromelain has an excellent distribution from blood to rhinosinusal mucosa in exhibition anti-inflammatory activity.
Based on the findings, researchers said, "Its (bromelain) diffusion ability may allow the use of bromelain as an anti-inflammatory agent in paranasal sinus pathologies".
In a pilot study, researchers evaluated the efficacy, tolerability, and impact on the quality of life (QoL) of bromelain tablets (500 FIP) in patients with chronic rhinosinusitis (CRS).
According to the results from 12 patients suffering from CRS with (CRS+NP) or without (CRS-NP) nasal polyps who had undergone prior sinus surgery, treatment with bromelain tablets (500 FIP) for 3 months, exerted a strong effect in symptom scores (Total Symptom Scores: TSS); a Total Rhinoscopy Score (TRS) and the Sinonasal Outcome Test 20 (SNOT-20 GAV) with no side effects.
Dr. Büttner L, the lead scientist wrote in the final report, "Preliminary results indicate good tolerability, symptom control, and improvement in QoL for the treatment of CRS using bromelain tablets (500 FIP)".
Taken altogether, bromelain may be considered supplements for the treatment of chronic rhinosinusitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain's penetration into the blood and sinonasal mucosa in patients with chronic rhinosinusitis by Passali D1, Passali GC2, Bellussi LM1, Sarafoleanu C3, Loglisci M1, Manea C3, Iosif C4, Passali FM. (PubMed)
(2) Efficacy and tolerability of bromelain in patients with chronic rhinosinusitis--a pilot study by Büttner L1, Achilles N, Böhm M, Shah-Hosseini K, Mösges R. (PubMed)
(3) Impact of Tobacco Smoke on Chronic Rhinosinusitis – A Review of the Literature by Douglas D. Reh, MD,1 Thomas S. Higgins, MD,1 and Timothy L. Smith, MD, MPH. (PMC)
Chronic Rhinosinusitis (CRS) is an inflammation of the sinuses and nasal cavity that last more than 12 weeks.
According to statistics, the prevalence of CRS in Korea, Europe, and the US is approximately 7%, 10%, and 12%, respectively.
The exact causes of CRS are not identified. However, some researches suggested that infection that does not heal itself due to the inability of the immune system to destroy all the infectious pathogens in the acute phase of infection may play a critical role to the onset of the condition.
Symptoms of CRS are totally depending on the state of severity. Some patients may experience symptoms of facial pressure or pain, post-nasal drainage, nasal blockage, anosmia or hyposmia, or fatigue.
Conventionally, medications used for the treatment of CRS are focusing on reducing symptoms and improved quality of life, inclduing prescribed antibiotics in case of bacterial infection.
If all medicines fail, surgery may be necessary.
Out of many risk factors associated with the onset of CRS, some researchers suggested that cigarette smoking may have a strong and negative impact on the syndrome.
Dr. Douglas D. Reh, the lead scientist wrote, " Environmental factors such as inhaled pollutants like cigarette smoke may play a significant role in diseases of the upper airway including chronic rhinosinusitis (CRS)".
And, "There is clear evidence in the literature that cigarette smoke, either through active smoking or passive exposure to SHS, contributes to CRS".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to discover a potential ingredient for the treatment of chronic rhinosinusitis, researchers investigated the penetration of bromelain into sinonasal mucosa in patients with chronic rhinosinusitis (CRS), compared to the control group.
40 participants with CRS were divided into 2 groups equally either treated by bromelain derived from pineapple (Ananas comosus) or control.
Bromelain 500 mg tablet twice daily administered for 30 days in the treatment group displayed a significant effect in reduced inflammation in patients with CRS compared to control.
In other words, bromelain has an excellent distribution from blood to rhinosinusal mucosa in exhibition anti-inflammatory activity.
Based on the findings, researchers said, "Its (bromelain) diffusion ability may allow the use of bromelain as an anti-inflammatory agent in paranasal sinus pathologies".
In a pilot study, researchers evaluated the efficacy, tolerability, and impact on the quality of life (QoL) of bromelain tablets (500 FIP) in patients with chronic rhinosinusitis (CRS).
According to the results from 12 patients suffering from CRS with (CRS+NP) or without (CRS-NP) nasal polyps who had undergone prior sinus surgery, treatment with bromelain tablets (500 FIP) for 3 months, exerted a strong effect in symptom scores (Total Symptom Scores: TSS); a Total Rhinoscopy Score (TRS) and the Sinonasal Outcome Test 20 (SNOT-20 GAV) with no side effects.
Dr. Büttner L, the lead scientist wrote in the final report, "Preliminary results indicate good tolerability, symptom control, and improvement in QoL for the treatment of CRS using bromelain tablets (500 FIP)".
Taken altogether, bromelain may be considered supplements for the treatment of chronic rhinosinusitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain's penetration into the blood and sinonasal mucosa in patients with chronic rhinosinusitis by Passali D1, Passali GC2, Bellussi LM1, Sarafoleanu C3, Loglisci M1, Manea C3, Iosif C4, Passali FM. (PubMed)
(2) Efficacy and tolerability of bromelain in patients with chronic rhinosinusitis--a pilot study by Büttner L1, Achilles N, Böhm M, Shah-Hosseini K, Mösges R. (PubMed)
(3) Impact of Tobacco Smoke on Chronic Rhinosinusitis – A Review of the Literature by Douglas D. Reh, MD,1 Thomas S. Higgins, MD,1 and Timothy L. Smith, MD, MPH. (PMC)
Saturday, May 16, 2020
Herbal Bilberry Inhibits Oral Candida Biofilms Naturally and Effectively
Candida is a class of yeasts that cause fungal infections worldwide.
Candida albicans is a member of a large group of an organism whose cells contain complex structures enclosed within the membranes, including yeast and mold that live among the gut flora in the human mouth and gastrointestinal tract.
Under normal circumstances, Candida albicans do not cause harmful effects, but overgrowth results in candidiasis.
Oral candidiasis is an oral condition infected by the fungal C. albicans found mostly in people with a weakened immune system including patients who are taking the immune-suppressive medicine.
Biofilms are microbial communities in which cells stick to each other and often also to a surface.
Symptoms of oral Candida overgrowth include worse in the damp day, persistence drowsiness, lack of coordination, headaches, mood swing, loss of balance, rashes, bad breath, dry mouth, and postnasal drip.
If you experience some of the aforementioned symptoms, please make sure you check with your doctor for early treatment.
There are many risk factors associated with Candida overgrowth including medical conditions that cause weakened immune system, inhalant medicine, low level of stomach acids, and pregnancy.
Some researchers suggested aging may be one of the major risk factors that cause Candida overgrowth
Dr. Aikaterini Flevari, the lead scientists said, "Candida species remain the most important cause of opportunistic infections worldwide, affecting predominantly patients over 65 years old, while they are considered to be the fourth most common cause of nosocomial bloodstream infections".
And, "The rapidly growing elderly population has specific physiological characteristics, which makes it susceptible to colonization and subsequent infection due to Candida species".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
On finding a potential herbal medicine against oral Candida biofilms., researchers examined the efficacy of cranberry fruit (Vaccinium macrocarpon Aiton) and two other red fruits (Vaccinium myrtillus L. and Malpighia punicifolia L.) on Candida albicans and Candida glabrata yeasts.
According to the low concentration added to the culture medium, the combined extract displayed significant anti-adhesion activity against Candida spp.
Furthermore, the pretreatment of surfaces with the extract also exerted a strong anti-adhesion activity mainly against C. glabrata yeasts and antibiofilm activity against C. albicans.
These results suggested that the extract inhibitory activity was dependent on concentration, species, and strain.
Moreover, observed the activity of three subfractions enriched in pro-anthocyanidins, researchers found that the components showed an anti-adhesion activity at low concentrations.
In other words, crude extracts of cranberry and Vaccinium myrtillus L. and Malpighia punicifolia L.) and their fractions process potential in the prevention of biofilms of C. glabrata.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanidins may be considered a functioning remedy against oral Candida biofilms, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Promising results of cranberry in the prevention of oral Candida biofilms by Girardot M1, Guerineau A, Boudesocque L, Costa D, Bazinet L, Enguehard-Gueiffier C, Imbert C. (PubMed)
Candida albicans is a member of a large group of an organism whose cells contain complex structures enclosed within the membranes, including yeast and mold that live among the gut flora in the human mouth and gastrointestinal tract.
Under normal circumstances, Candida albicans do not cause harmful effects, but overgrowth results in candidiasis.
Oral candidiasis is an oral condition infected by the fungal C. albicans found mostly in people with a weakened immune system including patients who are taking the immune-suppressive medicine.
Biofilms are microbial communities in which cells stick to each other and often also to a surface.
Symptoms of oral Candida overgrowth include worse in the damp day, persistence drowsiness, lack of coordination, headaches, mood swing, loss of balance, rashes, bad breath, dry mouth, and postnasal drip.
If you experience some of the aforementioned symptoms, please make sure you check with your doctor for early treatment.
There are many risk factors associated with Candida overgrowth including medical conditions that cause weakened immune system, inhalant medicine, low level of stomach acids, and pregnancy.
Some researchers suggested aging may be one of the major risk factors that cause Candida overgrowth
Dr. Aikaterini Flevari, the lead scientists said, "Candida species remain the most important cause of opportunistic infections worldwide, affecting predominantly patients over 65 years old, while they are considered to be the fourth most common cause of nosocomial bloodstream infections".
And, "The rapidly growing elderly population has specific physiological characteristics, which makes it susceptible to colonization and subsequent infection due to Candida species".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
On finding a potential herbal medicine against oral Candida biofilms., researchers examined the efficacy of cranberry fruit (Vaccinium macrocarpon Aiton) and two other red fruits (Vaccinium myrtillus L. and Malpighia punicifolia L.) on Candida albicans and Candida glabrata yeasts.
According to the low concentration added to the culture medium, the combined extract displayed significant anti-adhesion activity against Candida spp.
Furthermore, the pretreatment of surfaces with the extract also exerted a strong anti-adhesion activity mainly against C. glabrata yeasts and antibiofilm activity against C. albicans.
These results suggested that the extract inhibitory activity was dependent on concentration, species, and strain.
Moreover, observed the activity of three subfractions enriched in pro-anthocyanidins, researchers found that the components showed an anti-adhesion activity at low concentrations.
In other words, crude extracts of cranberry and Vaccinium myrtillus L. and Malpighia punicifolia L.) and their fractions process potential in the prevention of biofilms of C. glabrata.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanidins may be considered a functioning remedy against oral Candida biofilms, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Promising results of cranberry in the prevention of oral Candida biofilms by Girardot M1, Guerineau A, Boudesocque L, Costa D, Bazinet L, Enguehard-Gueiffier C, Imbert C. (PubMed)
Friday, May 15, 2020
Bromelain Kills Gastrointestinal Cancer Cells in Vitro
Gastrointestinal cancer is a medical and chronic condition caused by the alternation of cell DNA in the gastrointestinal tract including the esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum, and anus.
Most cases of gastrointestinal cancer begin in the cell on the surface of the inner lining of the gastrointestinal tissue, before penetrating into the deeper layers.
The most common gastrointestinal cancer is gastric cancer, which is the fourth most commonly occurring cancer in men and the seventh most commonly occurring cancer in women.
According to worldwide statistics, over 1 million new cases were diagnosed in 2018 with the South Korean leading the map, second to Mongolia.
In other words, if you are Asain, you are at an increased risk of gastric cancer.
At the advanced stage, the cancer cell of the affected tissues can travel a distance away to infect the other tissues and organs, leading to secondary metastasis.
Epidemiologically, primary gastrointestinal cancer is more likely to spread to the stomach, esophageal cancer, breast cancer, renal cell carcinoma, and ovarian cancer.
Most common symptoms of gastrointestinal cancer include
* Throw up blood with the color of coffee grounds. if the bleeding cancer is located in the esophagus or stomach
* Black stool if the bleeding cancer is located in the stomach and small intestine.
* Stool red with visible blood if the bleeding cancer is located in the large intestines.
Persistent bleeding to lead anemia due to a large amount of blood loss.
If you have some of the aforementioned symptoms that do heal in a short period of time, you may have gastrointestinal cancer. Please check with your doctor to rule out the possibility.
If the bleeding is slow, it often doesn’t cause the person to throw up blood or have a change in their stool. Over time, though, slow bleeding can lead to a low red blood cell count, and make a person feel tired and weak.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient against gastrointestinal cancer, researchers examined the effects of bromelain and N-acetylcysteine, the two natural agents' anti-cancer effects.
In gastrointestinal cancer models to cisplatin, paclitaxel, 5-fluorouracil, and vincristine, a combination of bromelain and N-acetylcysteine with chemotherapeutic agents could give rise to an improved chemotherapeutic index.
In other words, chemo drugs used combined with bromelain and N-acetylcysteine are more effective in the inhibition of gastrointestinal cancer with lesser toxicity.
Furthermore, combined with bromelain and N-acetylcysteine also reduced the doses of chemo drugs used with the same efficacy.
Based on the findings, researchers said, "This represents a potentially efficacious strategy for the enhancement of microscopic cytoreduction".
Moreover, in the examination of the effects of bromelain (BR) and N-acetylcysteine (NAC) on MUC2 and MUC5AC which have been found to significantly contribute to the biology and pathogenesis of mucin-secreting gastrointestinal tumors, researchers found that in vitro (MKN45, KATOIII and LS174T cell lines) and in vivo (female nude mice bearing intraperitoneal MKN45 and LS174T), a combination of BR and NAC with dual effects on growth and mucin products of mucin-expressing tumor cells.
More precisely, the treatment of the combination of BR and NAC protected the gastric cells against the malignancies with the involvement of mucin pathology.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of gastrointestinal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potentiation of chemotherapeutics by bromelain and N-acetylcysteine: sequential and combination therapy of gastrointestinal cancer cells by Amini A1, Masoumi-Moghaddam S1, Ehteda A1, Liauw W2, Morris DL. (PubMed)
(2) Depletion of mucin in mucin-producing human gastrointestinal carcinoma: Results from in vitro and in vivo studies with bromelain and N-acetylcysteine by Amini A1, Masoumi-Moghaddam S1, Ehteda A1, Liauw W2, Morris DL. (PubMed)
Most cases of gastrointestinal cancer begin in the cell on the surface of the inner lining of the gastrointestinal tissue, before penetrating into the deeper layers.
The most common gastrointestinal cancer is gastric cancer, which is the fourth most commonly occurring cancer in men and the seventh most commonly occurring cancer in women.
According to worldwide statistics, over 1 million new cases were diagnosed in 2018 with the South Korean leading the map, second to Mongolia.
In other words, if you are Asain, you are at an increased risk of gastric cancer.
At the advanced stage, the cancer cell of the affected tissues can travel a distance away to infect the other tissues and organs, leading to secondary metastasis.
Epidemiologically, primary gastrointestinal cancer is more likely to spread to the stomach, esophageal cancer, breast cancer, renal cell carcinoma, and ovarian cancer.
Most common symptoms of gastrointestinal cancer include
* Throw up blood with the color of coffee grounds. if the bleeding cancer is located in the esophagus or stomach
* Black stool if the bleeding cancer is located in the stomach and small intestine.
* Stool red with visible blood if the bleeding cancer is located in the large intestines.
Persistent bleeding to lead anemia due to a large amount of blood loss.
If you have some of the aforementioned symptoms that do heal in a short period of time, you may have gastrointestinal cancer. Please check with your doctor to rule out the possibility.
If the bleeding is slow, it often doesn’t cause the person to throw up blood or have a change in their stool. Over time, though, slow bleeding can lead to a low red blood cell count, and make a person feel tired and weak.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient against gastrointestinal cancer, researchers examined the effects of bromelain and N-acetylcysteine, the two natural agents' anti-cancer effects.
In gastrointestinal cancer models to cisplatin, paclitaxel, 5-fluorouracil, and vincristine, a combination of bromelain and N-acetylcysteine with chemotherapeutic agents could give rise to an improved chemotherapeutic index.
In other words, chemo drugs used combined with bromelain and N-acetylcysteine are more effective in the inhibition of gastrointestinal cancer with lesser toxicity.
Furthermore, combined with bromelain and N-acetylcysteine also reduced the doses of chemo drugs used with the same efficacy.
Based on the findings, researchers said, "This represents a potentially efficacious strategy for the enhancement of microscopic cytoreduction".
Moreover, in the examination of the effects of bromelain (BR) and N-acetylcysteine (NAC) on MUC2 and MUC5AC which have been found to significantly contribute to the biology and pathogenesis of mucin-secreting gastrointestinal tumors, researchers found that in vitro (MKN45, KATOIII and LS174T cell lines) and in vivo (female nude mice bearing intraperitoneal MKN45 and LS174T), a combination of BR and NAC with dual effects on growth and mucin products of mucin-expressing tumor cells.
More precisely, the treatment of the combination of BR and NAC protected the gastric cells against the malignancies with the involvement of mucin pathology.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of gastrointestinal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potentiation of chemotherapeutics by bromelain and N-acetylcysteine: sequential and combination therapy of gastrointestinal cancer cells by Amini A1, Masoumi-Moghaddam S1, Ehteda A1, Liauw W2, Morris DL. (PubMed)
(2) Depletion of mucin in mucin-producing human gastrointestinal carcinoma: Results from in vitro and in vivo studies with bromelain and N-acetylcysteine by Amini A1, Masoumi-Moghaddam S1, Ehteda A1, Liauw W2, Morris DL. (PubMed)
Thursday, May 14, 2020
Cramp Bark(Viburnum opulus) in the Prevention and Treatment of Ureteral Stones
The kidneys formed part of the secretary system are two bean-shaped organs located against the back muscles in the upper abdominal area.
The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.
Furthermore, the kidneys also maintain the fluid in the body by secreting extra water through urinary secretion.
Kidney stones are composed of mineral salts formed in the kidneys. Men account for 80% kidney stones incidence and are at risk of the formings between 30 and 40 years of age. About 75% of kidney stones are calcium stones.
According to statistics, kidney stones affect over 10% of the world population.
The causes of kidney stones are debatable. However, some researchers suggested that dehydration, food restriction, Rotavirus infection, over intake of calcium and supplements,... and high fat intake are associated with increased risk of forming kidney stones.
Ureteral stones are kidney stones that stuck in one or both ureters (the tubes that carry urine from the kidneys to the bladder), leading to the obstruction of the urinary secretion.
Most people with kidney stones are asymptomatic. However, some may experience symptoms of renal colic, an excruciating intermittent pain, usually in the flank (the area between the ribs and hip), that spreads across the abdomen, often to the genital area and inner thigh.
The pain tends to come in waves, gradually increasing to peak intensity, then fading, over about 20 to 60 minutes. The pain may radiate down the abdomen toward the groin or testis or vulva.
Other symptoms include nausea and vomiting, restlessness, sweating, and blood in the urine. A person may have an urge to urinate frequently, particularly as the stone passes down the ureter. Chills, fever, and abdominal distention.
Cramp Bark is an ornamental plant, genus Viburnum, belongings to the family Adoxaceae, native to Europe and Asia. T herbal medicine has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.
On finding a potential herbal medicine for the prevention and treatment of kidney stones, researchers examined the efficacy of Gilaburu (Viburnum opulus) extract in the treatment of distal ureteral stones <10 mm.
The study included data of a total of 103 patients retrospectively analyzed. divided into two groups: those given V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand (n=53) and those given only diclofenac sodium 50 mg peroral on-demand (n=50).
According to the expulsion rate assay, group treated with V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand showed a rate of stone expulsion that is significantly higher of 82% compared to the diclofenac 50 mg peroral on-demand treatment group of 66%.
Furthermore, elapsed time to stone expulsion was significantly shorter in the V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand of 9±1.8, compared to another group of 14±2.3 days.
Most importantly, the V. opulus group showed no need for additional treatment (URS and ESWL), and analgesic was less requirement compared to another group.
Based on the findings, researchers said, "V. opulus is an herbal treatment alternative that facilitates the passage of ureteral stones <10 mm. Prospective, randomized studies are needed to support these results".
Taken altogether, cramp bark(Viburnum opulus) may be considered a functional remedy for the treatment of ureteral stones, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The evaluation of the effectiveness of Gilaburu (Viburnum opulus L.) extract in the medical expulsive treatment of distal ureteral stones by Kızılay F1, Ülker V2, Çelik O2, Özdemir T1, Çakmak Ö2, Can E2, Nazlı O. (PubMed)
The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.
Furthermore, the kidneys also maintain the fluid in the body by secreting extra water through urinary secretion.
Kidney stones are composed of mineral salts formed in the kidneys. Men account for 80% kidney stones incidence and are at risk of the formings between 30 and 40 years of age. About 75% of kidney stones are calcium stones.
According to statistics, kidney stones affect over 10% of the world population.
The causes of kidney stones are debatable. However, some researchers suggested that dehydration, food restriction, Rotavirus infection, over intake of calcium and supplements,... and high fat intake are associated with increased risk of forming kidney stones.
Ureteral stones are kidney stones that stuck in one or both ureters (the tubes that carry urine from the kidneys to the bladder), leading to the obstruction of the urinary secretion.
Most people with kidney stones are asymptomatic. However, some may experience symptoms of renal colic, an excruciating intermittent pain, usually in the flank (the area between the ribs and hip), that spreads across the abdomen, often to the genital area and inner thigh.
The pain tends to come in waves, gradually increasing to peak intensity, then fading, over about 20 to 60 minutes. The pain may radiate down the abdomen toward the groin or testis or vulva.
Other symptoms include nausea and vomiting, restlessness, sweating, and blood in the urine. A person may have an urge to urinate frequently, particularly as the stone passes down the ureter. Chills, fever, and abdominal distention.
Cramp Bark is an ornamental plant, genus Viburnum, belongings to the family Adoxaceae, native to Europe and Asia. T herbal medicine has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.
On finding a potential herbal medicine for the prevention and treatment of kidney stones, researchers examined the efficacy of Gilaburu (Viburnum opulus) extract in the treatment of distal ureteral stones <10 mm.
The study included data of a total of 103 patients retrospectively analyzed. divided into two groups: those given V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand (n=53) and those given only diclofenac sodium 50 mg peroral on-demand (n=50).
According to the expulsion rate assay, group treated with V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand showed a rate of stone expulsion that is significantly higher of 82% compared to the diclofenac 50 mg peroral on-demand treatment group of 66%.
Furthermore, elapsed time to stone expulsion was significantly shorter in the V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand of 9±1.8, compared to another group of 14±2.3 days.
Most importantly, the V. opulus group showed no need for additional treatment (URS and ESWL), and analgesic was less requirement compared to another group.
Based on the findings, researchers said, "V. opulus is an herbal treatment alternative that facilitates the passage of ureteral stones <10 mm. Prospective, randomized studies are needed to support these results".
Taken altogether, cramp bark(Viburnum opulus) may be considered a functional remedy for the treatment of ureteral stones, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The evaluation of the effectiveness of Gilaburu (Viburnum opulus L.) extract in the medical expulsive treatment of distal ureteral stones by Kızılay F1, Ülker V2, Çelik O2, Özdemir T1, Çakmak Ö2, Can E2, Nazlı O. (PubMed)
Wednesday, May 13, 2020
Herbal Butterbur, the Potent Anti Somatoform Disorders Functional Remedy
Scientists may have found a natural herbal medicine for the prevention and treatment of Somatoform disorders with no side effects, according to studies.
Somatoform disorders are a group of psychiatric disorders that trigger unexplained physical symptoms.
Researchers do not the exact cause of the disorders. However, genetic preposition and family history are the 2 most common risk factors associated with the onset of the condition.
The most common symptoms include persistent pain or fatigue, emotional distress and problems functioning.
The American Family Physician in the article Somatoform disorders suggested up to 50 percent of primary care patients present with physical symptoms that cannot be explained by a general medical condition. Some of these patients meet the criteria for somatoform disorders.
Dr. Bener A, the lead scientist, in examining the gender effects on somatoform disorders in a sample size of 1689 patients, including 892 men and 797 women suggested
* The prevalence rate of somatoform disorders among the total screened sample was 23.9%.
* Housewives (43.5%) and men in administrative posts (37.9%) reported higher somatic symptoms compared to other professions.
* Prolonged depressive reaction was significantly higher in women compared to men.
* There was a significant gender difference in certain psychiatric diagnostic categories such as depressive episode, recurrent depressive disorder, dysthymia, and brief depressive reaction.
* Backache was the most commonly reported symptom in men, whereas a headache was more common in women.
These results clearly suggested being female is a risk factor of Somatoform disorders and symptoms of Somatoform disorders. Somatoform disorders affect the different aspects of the patient depending on gender.
Women with Somatoform disorders are more likely to experience psychological symptoms compared to males.
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
The herbal medicine has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin, and iso-S-petasin, etc.
With an aim to find a natural formula for the treatment of Somatoform disorder with no side effects, researchers at the University Hospital Zurich examined the effects of mixed herbal drug combination with and without butterbur (Ze 185) on patients with somatoform disorders.
In a total of 182 patients randomized for a 3-arm trial (butterbur root, valerian root, passionflower herb, lemon balm leaf versus valerian root, passionflower herb, lemon balm leaf versus placebo) compared to a fixed herbal drug combination (Ze 185 = 4-combination versus 3-combination without butterbur and placebo) in patients with somatoform disorders in a 2-week treatment in patients with somatization disorder (F45.0) and undifferentiated somatoform disorder (F45.1), researchers discovered the 4-combination was significantly superior to the 3-combination and placebo (4-combination > 3-combination > placebo) in all the primary and secondary parameters (PP-population).
The levels of anxiety and depression, according to the Anxiety (visual analog scale - VAS) and depression (Beck's Depression Inventory - BDI) are also decreased more in 4 combinations compared to others.
According to the Clinical Global Impression (CGI) rating scales, 4 combinations also showed reduced symptom severity and improved treatment response compared to 3 combinations.
The results are further reconfirmed by the ITT population analysis.
Where (ITT) analysis is a treatment in which patients enrolled and randomly allocated to treatment are included in the analysis and are analyzed in the groups to which they were randomized.
All tested subjects expressed no serious adverse effects during the course of experiments.
These results suggested that herbal preparation (Ze185) may be an efficacious and safe short-term treatment in patients with somatoform disorders.
Taken altogether, herbal Butterbur used alone or combined with other herbal medicine may be considered a functional herbal for prevention and combined with the primary medicine for the treatment of Somatoform disorder with no serious side effects,
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial by Melzer J, Schrader E, Brattström A, Schellenberg R, Saller R.(PubMed)
Somatoform disorders are a group of psychiatric disorders that trigger unexplained physical symptoms.
Researchers do not the exact cause of the disorders. However, genetic preposition and family history are the 2 most common risk factors associated with the onset of the condition.
The most common symptoms include persistent pain or fatigue, emotional distress and problems functioning.
The American Family Physician in the article Somatoform disorders suggested up to 50 percent of primary care patients present with physical symptoms that cannot be explained by a general medical condition. Some of these patients meet the criteria for somatoform disorders.
Dr. Bener A, the lead scientist, in examining the gender effects on somatoform disorders in a sample size of 1689 patients, including 892 men and 797 women suggested
* The prevalence rate of somatoform disorders among the total screened sample was 23.9%.
* Housewives (43.5%) and men in administrative posts (37.9%) reported higher somatic symptoms compared to other professions.
* Prolonged depressive reaction was significantly higher in women compared to men.
* There was a significant gender difference in certain psychiatric diagnostic categories such as depressive episode, recurrent depressive disorder, dysthymia, and brief depressive reaction.
* Backache was the most commonly reported symptom in men, whereas a headache was more common in women.
These results clearly suggested being female is a risk factor of Somatoform disorders and symptoms of Somatoform disorders. Somatoform disorders affect the different aspects of the patient depending on gender.
Women with Somatoform disorders are more likely to experience psychological symptoms compared to males.
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
The herbal medicine has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin, and iso-S-petasin, etc.
With an aim to find a natural formula for the treatment of Somatoform disorder with no side effects, researchers at the University Hospital Zurich examined the effects of mixed herbal drug combination with and without butterbur (Ze 185) on patients with somatoform disorders.
In a total of 182 patients randomized for a 3-arm trial (butterbur root, valerian root, passionflower herb, lemon balm leaf versus valerian root, passionflower herb, lemon balm leaf versus placebo) compared to a fixed herbal drug combination (Ze 185 = 4-combination versus 3-combination without butterbur and placebo) in patients with somatoform disorders in a 2-week treatment in patients with somatization disorder (F45.0) and undifferentiated somatoform disorder (F45.1), researchers discovered the 4-combination was significantly superior to the 3-combination and placebo (4-combination > 3-combination > placebo) in all the primary and secondary parameters (PP-population).
The levels of anxiety and depression, according to the Anxiety (visual analog scale - VAS) and depression (Beck's Depression Inventory - BDI) are also decreased more in 4 combinations compared to others.
According to the Clinical Global Impression (CGI) rating scales, 4 combinations also showed reduced symptom severity and improved treatment response compared to 3 combinations.
The results are further reconfirmed by the ITT population analysis.
Where (ITT) analysis is a treatment in which patients enrolled and randomly allocated to treatment are included in the analysis and are analyzed in the groups to which they were randomized.
All tested subjects expressed no serious adverse effects during the course of experiments.
These results suggested that herbal preparation (Ze185) may be an efficacious and safe short-term treatment in patients with somatoform disorders.
Taken altogether, herbal Butterbur used alone or combined with other herbal medicine may be considered a functional herbal for prevention and combined with the primary medicine for the treatment of Somatoform disorder with no serious side effects,
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial by Melzer J, Schrader E, Brattström A, Schellenberg R, Saller R.(PubMed)
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