Thyroid disease is a condition or malfunction of the thyroid. Hyperthyroidism is a condition in which the thyroid gland is overactive and produces too much thyroid hormones. Hypothyroidism is a condition in which the thyroid gland is underactive and produces very little thyroid hormones.
The thyroid gland is an endocrine gland located in the neck, consisting of two lobes connected by an isthmus with functions to secrete thyroid hormones (thyroxine/T4 and triiodothyronine/T3), and calcitonin.
Thyroid hormones play an important role in metabolism by stimulating almost every tissue in the body to produce proteins and increasing the amount of oxygen to the cells.
Abnormal thyroid hormone production can be diagnosed by examining whether the thyroid gland is enlarged or by taking a blood test or/and a radioactive iodine uptake test.
Thyrotoxicosis is a medical condition caused by an excess of thyroid hormone in the body.
More precisely, in thyrotoxicosis, patients experience a low level of thyroid-stimulating hormone, TSH in the bloodstream.
The most common treatment of thyrotoxicosis is the use of radioactive iodine and antithyroid medication, following by careful follow-up.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
The Sectie Geneesmiddelenbewaking in Postbus in examining the case of a 32-year-old healthy woman developed thyrotoxicosis induced symptoms chronic fatigue while taking capsules that contained ashwagandha herbal extract suggested* Taking ashwagandha herbal extract in reduced doses or occasionally do not cause thyrotoxicosis
* However, overdoses of ashwagandha herbal extract can induce clinical symptoms indicative of thyrotoxicosis.
* Discontinued ashwagandha herbal extract can resolve the symptoms spontaneously, according to the laboratory values.
The incidence also has been proved in the animal studies as ashwagandha can increase serum concentrations of thyroid hormones.
Based on the findings, researchers said, "thyrotoxicosis is a potentially serious side effect of ashwagandha".
Taken altogether, Ashwagandha overdose may induce thyrotoxicosis, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Thyrotoxicosis following the use of ashwagandha].[Article in Dutch] by van der Hooft CS1, Hoekstra A, Winter A, de Smet PA, Stricker BH. (PubMed)
Friday, May 29, 2020
Thursday, May 28, 2020
Herbal Chaste tree berry, the Male Contraceptive Functional Food
Recent study by a renowned institute suggested that Chaste tree berry may have a potential in improved male infertility as a contraceptive functional food.
Infertility is condition of inability of a couple to conceive after 12 months of unprotected sexual intercourse. It affects over 5 millions couple alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seeks help from professional specialist.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
According to the Indian Institute of Technology Roorkee, flavonoid-rich seed extracts of Chaste tree berry oral administration, promoted sperm numbers dwindled and slackness in their motility of that may impede fertility.
In extract fed male rats with four different concentrations after 15 days, treatment of all concentrations displayed a drop in weight with a marginal chance of fructose in seminal vesicles and epididymal alpha-glucosidase, probably involved in reducing the fertilizing ability of the spermatozoa.
Dr. Das S, the lead author said, "the seedextracts of V. negundo interfere with male reproductive function without producing adverse toxicity in other vital organs".
Interestingly, the same extract used in testing the antiandrogenic effects in dog model, administrated dogs showed a antagonized androgen action of exogenous testosterone on the male reproductive system, reducing sexual design and impeded sperm production and mobility.
In the duration of treatment of 30 and 60 days, the extract causes a disruption of the latter stages of spermatogenesis with devoid of spermatozoa passed through epididymides.
Furthermore, when the extract used combination with testosterone propionate, a ester of propionic acid,. dogs maintained the viability of spermatozoa with significantly increased the cellular heights of epididymides in compared non treatment dogs.
Taking together, chaste tree berry intake may be acted as infertile substance for male to prevent unwanted pregnancy of female partner, but the use of the herbal medicine for contraceptive purpose should only recommended by herbalists.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Reproduction in male rats is vulnerable to treatment with the flavonoid-rich seed extracts of Vitex negundo by Das S1, Parveen S, Kundra CP, Pereira BM.(PubMed)
(2) Antiandrogenic effects of a flavonoid-rich fraction of Vitex negundo seeds: a histological and biochemical study in dogs by Bhargava SK1(PubMed)
Infertility is condition of inability of a couple to conceive after 12 months of unprotected sexual intercourse. It affects over 5 millions couple alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seeks help from professional specialist.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
According to the Indian Institute of Technology Roorkee, flavonoid-rich seed extracts of Chaste tree berry oral administration, promoted sperm numbers dwindled and slackness in their motility of that may impede fertility.
In extract fed male rats with four different concentrations after 15 days, treatment of all concentrations displayed a drop in weight with a marginal chance of fructose in seminal vesicles and epididymal alpha-glucosidase, probably involved in reducing the fertilizing ability of the spermatozoa.
Dr. Das S, the lead author said, "the seedextracts of V. negundo interfere with male reproductive function without producing adverse toxicity in other vital organs".
Interestingly, the same extract used in testing the antiandrogenic effects in dog model, administrated dogs showed a antagonized androgen action of exogenous testosterone on the male reproductive system, reducing sexual design and impeded sperm production and mobility.
In the duration of treatment of 30 and 60 days, the extract causes a disruption of the latter stages of spermatogenesis with devoid of spermatozoa passed through epididymides.
Furthermore, when the extract used combination with testosterone propionate, a ester of propionic acid,. dogs maintained the viability of spermatozoa with significantly increased the cellular heights of epididymides in compared non treatment dogs.
Taking together, chaste tree berry intake may be acted as infertile substance for male to prevent unwanted pregnancy of female partner, but the use of the herbal medicine for contraceptive purpose should only recommended by herbalists.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Reproduction in male rats is vulnerable to treatment with the flavonoid-rich seed extracts of Vitex negundo by Das S1, Parveen S, Kundra CP, Pereira BM.(PubMed)
(2) Antiandrogenic effects of a flavonoid-rich fraction of Vitex negundo seeds: a histological and biochemical study in dogs by Bhargava SK1(PubMed)
Wednesday, May 27, 2020
Herbal Cleaver(Galium aparine),the Potential Antioxidant Remedy
Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals in the induction of oxidative stress.
In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.
Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.
However, in people with a weakened immune system, intake of dietary sources of antioxidants may be necessary.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.
Oxidative stress is a result of an imbalance of the ratio of free radicals and antioxidants in the body.
Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
On finding a potential compound for the treatment of diseases associated with oxidative stress, researchers compared the phenolic content and the antioxidant activity of Anthyllis vulneraria L., Fuchsia sp., Galium mollugo L., and Veronica beccabunga L.
According to the chemical analysis, the Galium mollugo polyphenol tannin, and flavonoid contents are 1.77 ± 0.05, 0.49 ± 0.04 and 0.16 ± 0.06 g/100 g dry weight) compared to those of Fuchsia species of 7.40 ± 0.8, 5.62 ± 0.7 and 0.72 ± 0.1 g/100 g dry weight and Anthyllis vulneraria (0.68 ± 0.02, 0.17 ± 0.03 and 0.45 ± 0.01 g/100 g dry weight., respectively.
More precisely, herbal cleaver(Galium aparine) showed a higher total polyphenol, tannin, and flavonoid contents than A. vulneraria but lower, compared to those of Fuchsia sp.
In other words, all antioxidant compounds found in herbal cleaver(Galium aparine) work together to exert anti-free radical activity in the stimulation of the onset of oxidative stress.
Taken altogether, Cleaver processed an antioxidant activity against the risk of oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Examination of secondary metabolites and antioxidant capacity of Anthyllis vulneraria, Fuchsia sp., Galium mollugo and Veronica beccabunga by Csepregi R1,2, Bencsik T1, Papp N. (PubMed).
In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.
Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.
However, in people with a weakened immune system, intake of dietary sources of antioxidants may be necessary.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.
Oxidative stress is a result of an imbalance of the ratio of free radicals and antioxidants in the body.
Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
On finding a potential compound for the treatment of diseases associated with oxidative stress, researchers compared the phenolic content and the antioxidant activity of Anthyllis vulneraria L., Fuchsia sp., Galium mollugo L., and Veronica beccabunga L.
According to the chemical analysis, the Galium mollugo polyphenol tannin, and flavonoid contents are 1.77 ± 0.05, 0.49 ± 0.04 and 0.16 ± 0.06 g/100 g dry weight) compared to those of Fuchsia species of 7.40 ± 0.8, 5.62 ± 0.7 and 0.72 ± 0.1 g/100 g dry weight and Anthyllis vulneraria (0.68 ± 0.02, 0.17 ± 0.03 and 0.45 ± 0.01 g/100 g dry weight., respectively.
More precisely, herbal cleaver(Galium aparine) showed a higher total polyphenol, tannin, and flavonoid contents than A. vulneraria but lower, compared to those of Fuchsia sp.
In other words, all antioxidant compounds found in herbal cleaver(Galium aparine) work together to exert anti-free radical activity in the stimulation of the onset of oxidative stress.
Taken altogether, Cleaver processed an antioxidant activity against the risk of oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Examination of secondary metabolites and antioxidant capacity of Anthyllis vulneraria, Fuchsia sp., Galium mollugo and Veronica beccabunga by Csepregi R1,2, Bencsik T1, Papp N. (PubMed).
Tuesday, May 26, 2020
Herbal Butterbur, the Natural Anti High Blood Cholesterol Remedy, Scientists Say
Herbal Butterbur may have a potential and positive effect on reducing the levels of blood cholesterol with no side effects, some scientists suggested.
Cholesterol is a waxy substance needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat.
However, too much cholesterol can be dangerous because cholesterol cannot dissolve in your blood.
The special particle called lipoprotein moves this waxy, soft substance from place to place, leading to cholesterol accumulation in the arterial wall that disrupts the risk of oxygenic blood transportation to the heart, a major cause of cardiovascular disease.
There are 2 types of cholesterol. The high-density lipoprotein which returns the blood cholesterol to the liver for future use and the low-density lipoprotein which processes a number of aforementioned functions.
The healthy ratio that maximizes the body functions is 4 (low-density lipoprotein or bad cholesterol) to 1 (high-density lipoprotein or good cholesterol. Any numbers less than 4 are considered healthy.
Some researchers suggested although there are many risk factors associated with the onset of high blood cholesterol, an unhealthy diet is one major and accumulated risk of the syndrome.
Dr. Robert L. Rosenthal in the study "Effectiveness of altering serum cholesterol levels without drugs" wrote, "Drug therapy with statins and other agents can result in dramatic lipid-lowering effects. Despite the wealth of data supporting the beneficial effects of pharmacologic therapy on cardiovascular risk, patients often express a desire to accomplish similar goals with diet alone".
And, "... a variety of dietary strategies designed to lower lipid levels, including the American Heart Association diet, the Ornish diet, the Mediterranean diet, exercise, phytosterols, fiber, soy products, and fish oil".
These results strongly suggested you can lower your blood cholesterol by following a healthy diet and moderate exercise without using drugs.
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
The herbal medicine has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts,, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin, and iso-S-petasin, etc.
On finding a natural ingredient for the treatment of high blood cholesterol, researchers at the Chungnam National University, Gyeongsan examined the effect of the butanol fraction from the methanol extract of butterbur (Petasites japonicus Max.) (BMP) on the plasma lipid profile and oxidative damage of liver in mice challenged with monosodium l-glutamate (MSG).
The study included ICR mice (6-8 weeks old, male) fed with BMP (0.1% or 0.3%) for 1 week, and on day 7, MSG (4 mg/g) administered intraperitoneally.
Before application of BMP, administration of MSG showed a significant decrease of antioxidant biomarkers such as total glutathione level and antioxidant enzyme activities such as glutathione reductase (GR), glutathione peroxidase (GPx), glutathione S-transferase (GST), and quinone reductase (NQO1) and increase of the levels of reactive oxygen species (ROS).
After the injection of BMP supplementation, treated mice markedly enhanced the hepatic antioxidant enzyme activities.
Furthermore, BMP supplementation decreased total cholesterol, atherogenic index, and low-density lipoprotein-cholesterol, compared to the MSG-treated group.
Dr. Park CH the lead author in the hear team wrote, "Based on these results, it was proposed that BMP improve the plasma lipid profiles and decrease the oxidative stress by up-regulating the hepatic antioxidant enzymes in mice challenged with MSG.".
Additionally, the review of the anti-obesity effect of an extract of Petasites japonicus (a culinary vegetable from Eastern Asia) (PJET) on a murine adipocyte cell line (3T3-L1) and on diet-induced obesity-prone mice, researchers showed PJET lowered the body weight gain and visceral fat tissue accumulation and ameliorated the plasma cholesterol concentration.
Furthermore, PJET significantly attenuated three adipogenic transcription factors, which play a crucial Role in adipogenic induction associated with adipocyte differentiation and cholesterol homeostasis, and genes involved higher levels of total cholesterol.
These results indicated herbal Butterbur inhibited levels of bad cholesterol through many mechanisms, including genes expression, transcription factors, and levels of antioxidants
Taken altogether, herbal Butterbur processed a number of bioactive compounds that may be considered a functioning remedy for the prevention and treatment of high blood cholesterol with no side effect, pending to the large sample size and multi-center human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer, and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Butterbur (Petasites japonicus Max.) extract improves lipid profiles and antioxidant activities in monosodium L-glutamate-challenged mice by Park CH, Kim MY, Sok DE, Kim JH, Lee JH, Kim MR.(PubMed)
(2) Suppression of murine preadipocyte differentiation and reduction of visceral fat accumulation by a Petasites japonicus ethanol extract in mice fed a high-fat diet by Watanabe T, Hata K, Hiwatashi K, Hori K, Suzuki N, Itoh H.(PubMed)
Cholesterol is a waxy substance needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat.
However, too much cholesterol can be dangerous because cholesterol cannot dissolve in your blood.
The special particle called lipoprotein moves this waxy, soft substance from place to place, leading to cholesterol accumulation in the arterial wall that disrupts the risk of oxygenic blood transportation to the heart, a major cause of cardiovascular disease.
There are 2 types of cholesterol. The high-density lipoprotein which returns the blood cholesterol to the liver for future use and the low-density lipoprotein which processes a number of aforementioned functions.
The healthy ratio that maximizes the body functions is 4 (low-density lipoprotein or bad cholesterol) to 1 (high-density lipoprotein or good cholesterol. Any numbers less than 4 are considered healthy.
Some researchers suggested although there are many risk factors associated with the onset of high blood cholesterol, an unhealthy diet is one major and accumulated risk of the syndrome.
Dr. Robert L. Rosenthal in the study "Effectiveness of altering serum cholesterol levels without drugs" wrote, "Drug therapy with statins and other agents can result in dramatic lipid-lowering effects. Despite the wealth of data supporting the beneficial effects of pharmacologic therapy on cardiovascular risk, patients often express a desire to accomplish similar goals with diet alone".
And, "... a variety of dietary strategies designed to lower lipid levels, including the American Heart Association diet, the Ornish diet, the Mediterranean diet, exercise, phytosterols, fiber, soy products, and fish oil".
These results strongly suggested you can lower your blood cholesterol by following a healthy diet and moderate exercise without using drugs.
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
The herbal medicine has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts,, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin, and iso-S-petasin, etc.
On finding a natural ingredient for the treatment of high blood cholesterol, researchers at the Chungnam National University, Gyeongsan examined the effect of the butanol fraction from the methanol extract of butterbur (Petasites japonicus Max.) (BMP) on the plasma lipid profile and oxidative damage of liver in mice challenged with monosodium l-glutamate (MSG).
The study included ICR mice (6-8 weeks old, male) fed with BMP (0.1% or 0.3%) for 1 week, and on day 7, MSG (4 mg/g) administered intraperitoneally.
Before application of BMP, administration of MSG showed a significant decrease of antioxidant biomarkers such as total glutathione level and antioxidant enzyme activities such as glutathione reductase (GR), glutathione peroxidase (GPx), glutathione S-transferase (GST), and quinone reductase (NQO1) and increase of the levels of reactive oxygen species (ROS).
After the injection of BMP supplementation, treated mice markedly enhanced the hepatic antioxidant enzyme activities.
Furthermore, BMP supplementation decreased total cholesterol, atherogenic index, and low-density lipoprotein-cholesterol, compared to the MSG-treated group.
Dr. Park CH the lead author in the hear team wrote, "Based on these results, it was proposed that BMP improve the plasma lipid profiles and decrease the oxidative stress by up-regulating the hepatic antioxidant enzymes in mice challenged with MSG.".
Additionally, the review of the anti-obesity effect of an extract of Petasites japonicus (a culinary vegetable from Eastern Asia) (PJET) on a murine adipocyte cell line (3T3-L1) and on diet-induced obesity-prone mice, researchers showed PJET lowered the body weight gain and visceral fat tissue accumulation and ameliorated the plasma cholesterol concentration.
Furthermore, PJET significantly attenuated three adipogenic transcription factors, which play a crucial Role in adipogenic induction associated with adipocyte differentiation and cholesterol homeostasis, and genes involved higher levels of total cholesterol.
These results indicated herbal Butterbur inhibited levels of bad cholesterol through many mechanisms, including genes expression, transcription factors, and levels of antioxidants
Taken altogether, herbal Butterbur processed a number of bioactive compounds that may be considered a functioning remedy for the prevention and treatment of high blood cholesterol with no side effect, pending to the large sample size and multi-center human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer, and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Butterbur (Petasites japonicus Max.) extract improves lipid profiles and antioxidant activities in monosodium L-glutamate-challenged mice by Park CH, Kim MY, Sok DE, Kim JH, Lee JH, Kim MR.(PubMed)
(2) Suppression of murine preadipocyte differentiation and reduction of visceral fat accumulation by a Petasites japonicus ethanol extract in mice fed a high-fat diet by Watanabe T, Hata K, Hiwatashi K, Hori K, Suzuki N, Itoh H.(PubMed)
Monday, May 25, 2020
Herbal Bilberry Protects the Cells Integrity Against Cancer
Cancer is a group of cell mutated diseases caused by the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of an organ. At the early, most people with cancer are asymptomatic, however, at the later, due to the size and the tumor, patients may experience the general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort and loss of appetite and localized symptoms such as severe pain and bleeding.
The exact causes of cancer are not identified. As of today, researchers do not know why one person develops cancer and another doesn’t, even they share some common risk factors of the disease.
However, most prevalent factors associated with the cancer onset include age, family history, long-term exposure to certain cancer induced chemicals, use of tobacco and excessive alcohol drinking,..... the list goes on and on, depending on the types of cancer.
Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.
Dr. Karen Basen-Engquist, in the evaluation of obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".
And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".
The findings strongly indicated the risk of cancer is increased substantially in obese.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Searching the list of natural compounds with a strong potential for the treatment of cancer with no side effects, scientists investigated the secondary metabolites including flavonoids (1-8), caffeic (9) and chlorogenic (10) acids from the extract of Sakhalin bilberry Vaccinium smallii leaves in vitro.
All 10 metabolites included in the study displayed a significant effect in the inhibition of EGF-induced neoplastic transformation in the conversion of normal cells into tumor cells of mouse JB6 Cl 41 P+ cells.
Furthermore, none of the compound isolated from bilberry extract showed non-toxic against JB6 Cl 41 P+ cells up to a concentration of 200 µm.
The results suggested that bilberry secondary metabolites protect the normal against the alternation of cells DNA without causing harm to the nearby healthy normal cells.
In HL60 cells, injection of bilberry extract-induced apoptotic cell bodies and nucleosomal DNA fragmentation.
However, bilberry did not exert similar effects against the HCT116. The proportion of apoptotic cells induced in HCT116 was much lower than that in HL60 cells, without the presence of DNA fragmentation.
According to the extracted analysis, the efficacy of bilberry against cancer cell lines was attributed to the bioactive phenolic compounds, including anthocyanins in initiating the free radical scavenging property.
Dr. Katsube N, the lead scientist after taking into account co and confounders wrote in the final report, "These results indicate that the bilberry extract and the anthocyanins, bearing delphinidin or malvidin as the aglycon, inhibit the growth of HL60 cells through the induction of apoptosis".
Taken altogether, bilberry processed significant bioactive secondary metabolites may be considered a functional remedy for the prevention and treatment of cancer, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cancer-preventive activities of secondary metabolites from leaves of the bilberryVaccinium smallii A. Gray by Mechikova GY1, Kuzmich AS, Ponomarenko LP, Kalinovsky AI, Stepanova TA, Fedorov SN, Stonik VA. (PubMed)
(2) Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins by Katsube N1, Iwashita K, Tsushida T, Yamaki K, Kobori M. (PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
Sunday, May 24, 2020
Herbal Artichoke May Process Anti Chronic Myeloid Leukemia (CML) Potency, According Medical Literature
Artichoke may be the next target to extract the ingredient needed for the treatment of chronic myeloid leukemia (CML), according to studies.
Chronic myeloid leukemia (CML) is a type of cancer characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood.
The exact causes of CML are unknown. Some researchers suggested that the causes of DNA alternation of the myeloid cells may be associated with the abnormal function of genes involved in cell cycle division and tumor suppression.
Epidemiologically, most people with CML are associated with risk factors of aging, male gender, and long-term exposure to radiation. However, most people with some of the risk factors do not develop CML.
According to the statistic provided by the American Cancer Society, in 2018, about 8,430 new cases will be diagnosed with CML (4,980 in men and 3,450 in women). The disease also causes the death of 1,090 people, including 620 men and 470 women.
The most common symptoms of CML include easy bleeding and tired, unintended weight loss, pain or fullness below the ribs on the left side, pale skin.
If you experience some of the above symptoms, please check with your doctor to rule out the possibility of the disease.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of chronic myeloid leukemia evaluated the methanol extract of CCL flower and/or cynaropicrin showed remarkable anti-proliferative activity in vitro models of the leukocyte cancer cell.
In other words, the study was carried out to examined the effect of CCL extract on human K562 CML and K562 imatinib-resistant (IMAR) cell proliferation and on p210BCR/ABL expression.
Where p210BCR/ABL chimeric protein is considered to be implicated in the pathogenesis of Philadelphia chromosome-positive human leukemias.
Injection of CCL extract showed to inhibit the cell viability of both K562 CML human cell line and K562 IMAR, according to the MTT assay.
In protein implication, cynaropicrin and its deacyl derivative from the CCL extract displayed a significant capability in the inhibition of the p210BCR/ABL oncoprotein, according to the Western blot technique.
In cancer viability assay, CCL extracts exerted a similar effect compared to that of imatinib or its cancer growth arrest in CML.
In the depth differentiation, researchers also found that CCL extract also showed strong inhibition of the delay or overcome the resistance of CML to chemotherapy.
Taken altogether, artichoke with the abundantly bioactive compounds may be considered a functional remedy for the prevention and treatment of chronic myeloid leukemia with no side effects, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1)Biochemical and chemical characterization of Cynara cardunculus L. extract and its potential use as co-adjuvant therapy of chronic myeloid leukemia by Russo A1, Perri M1, Cione E1, Di Gioia ML1, Nardi M1, Cristina Caroleo M. (PubMed)
Chronic myeloid leukemia (CML) is a type of cancer characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood.
The exact causes of CML are unknown. Some researchers suggested that the causes of DNA alternation of the myeloid cells may be associated with the abnormal function of genes involved in cell cycle division and tumor suppression.
Epidemiologically, most people with CML are associated with risk factors of aging, male gender, and long-term exposure to radiation. However, most people with some of the risk factors do not develop CML.
According to the statistic provided by the American Cancer Society, in 2018, about 8,430 new cases will be diagnosed with CML (4,980 in men and 3,450 in women). The disease also causes the death of 1,090 people, including 620 men and 470 women.
The most common symptoms of CML include easy bleeding and tired, unintended weight loss, pain or fullness below the ribs on the left side, pale skin.
If you experience some of the above symptoms, please check with your doctor to rule out the possibility of the disease.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of chronic myeloid leukemia evaluated the methanol extract of CCL flower and/or cynaropicrin showed remarkable anti-proliferative activity in vitro models of the leukocyte cancer cell.
In other words, the study was carried out to examined the effect of CCL extract on human K562 CML and K562 imatinib-resistant (IMAR) cell proliferation and on p210BCR/ABL expression.
Where p210BCR/ABL chimeric protein is considered to be implicated in the pathogenesis of Philadelphia chromosome-positive human leukemias.
Injection of CCL extract showed to inhibit the cell viability of both K562 CML human cell line and K562 IMAR, according to the MTT assay.
In protein implication, cynaropicrin and its deacyl derivative from the CCL extract displayed a significant capability in the inhibition of the p210BCR/ABL oncoprotein, according to the Western blot technique.
In cancer viability assay, CCL extracts exerted a similar effect compared to that of imatinib or its cancer growth arrest in CML.
In the depth differentiation, researchers also found that CCL extract also showed strong inhibition of the delay or overcome the resistance of CML to chemotherapy.
Taken altogether, artichoke with the abundantly bioactive compounds may be considered a functional remedy for the prevention and treatment of chronic myeloid leukemia with no side effects, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1)Biochemical and chemical characterization of Cynara cardunculus L. extract and its potential use as co-adjuvant therapy of chronic myeloid leukemia by Russo A1, Perri M1, Cione E1, Di Gioia ML1, Nardi M1, Cristina Caroleo M. (PubMed)
Saturday, May 23, 2020
Herbal Bilberry, the Natural Treatment for Varicose Veins with No Side Effects
Varicose veins are the medical condition in which the superficial veins have become enlarged and twisted.
The condition has been found to induce bleeding or superficial thrombophlebitis if left untreated.
The most common causes of varicose veins are found just under the skin in the legs, leading to the symptoms of fullness and pain in the affected location accompanied by symptoms of achy or heavy feeling in the legs. The pain is also worsened after a long time of sitting or standing for a long time and skin discoloration around the area.
Some patients with painful varicose veins also experience symptoms of burning, throbbing, muscle cramping, and swelling in the lower legs and itching.
Out of many risk factors associated with the onset of varicose veins, aging due to wear and tear on the valves in the veins that help regulate blood flow may be one of the most common risk factors.
Dr. Caggiati A in the study of age-related variations of varicose veins, wrote, "Varicose SVs were more frequent in the older group (62%) than in younger one (39%) owing to a higher prevalence of limbs with combined saphenous veins (SVs) and Stributaries of the SVs (STVs) varicosities (respectively, 59% and 37%)".
And, "varicose disease may progressively extend in an antegrade fashion, spreading from the STVs to the SVs".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find a natural ingredient for the treatment of varicose veins and chronic venous insufficiency (CVI), researchers compared the efficacy of Pycnogenol, venoruton, troxerutin, the complex diosmin-hesperidin, Antistax, Mirtoselect (bilberry), escin, and the combination Venoruton-Pycnogenol (VE-PY) against the therapeutic compressions.
The study included 1,051 patients who completed the registry. During the experiment, there are no safety or tolerability problems observed.
Mirtoselect (bilberry) showed a significant effect on skin flux but in a lesser extent compared to those of Venoruton, Pycnogenol, and the combination VE-PY.
The edema score was decreased more effectively with the combination and with Pycnogenol compared to the other treatment group including the Mirtoselect (bilberry).
According to the improvement in symptoms score, Pycnogenol and compression showed a larger decrease in oxidative stress compared to the Pycnogenol, Venoruton, Mirtoselect (bilberry) and with the VE-PY combination.
However, the efficacy of Pycnogenol and the combination are competitive with stockings that do not have the same tolerability in warmer climates compared to other groups.
The findings suggested that the tested compounds processed anti chronic venous insufficiency (CVI) and varicose veins properties.
Taken altogether, Mirtoselect (bilberry) may be considered a functioning remedy for the treatment of varicose veins with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Management of Varicose Veins and Chronic Venous Insufficiency in a Comparative Registry with Nine Venoactive Products in Comparison with Stockings by Belcaro G1, Dugall M1, Luzzi R1, Corsi M1, Ledda A1, Ricci A1, Pellegrini L1, Cesarone MR1, Hosoi M1, Errichi BM1, Cornelli U1, Cotellese R1, Agus G1, Feragalli B. (PubMed)
(2) Age-related variations of varicose veins anatomy by Caggiati A1, Rosi C, Heyn R, Franceschini M, Acconcia MC. (PubMed)
The condition has been found to induce bleeding or superficial thrombophlebitis if left untreated.
The most common causes of varicose veins are found just under the skin in the legs, leading to the symptoms of fullness and pain in the affected location accompanied by symptoms of achy or heavy feeling in the legs. The pain is also worsened after a long time of sitting or standing for a long time and skin discoloration around the area.
Some patients with painful varicose veins also experience symptoms of burning, throbbing, muscle cramping, and swelling in the lower legs and itching.
Out of many risk factors associated with the onset of varicose veins, aging due to wear and tear on the valves in the veins that help regulate blood flow may be one of the most common risk factors.
Dr. Caggiati A in the study of age-related variations of varicose veins, wrote, "Varicose SVs were more frequent in the older group (62%) than in younger one (39%) owing to a higher prevalence of limbs with combined saphenous veins (SVs) and Stributaries of the SVs (STVs) varicosities (respectively, 59% and 37%)".
And, "varicose disease may progressively extend in an antegrade fashion, spreading from the STVs to the SVs".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find a natural ingredient for the treatment of varicose veins and chronic venous insufficiency (CVI), researchers compared the efficacy of Pycnogenol, venoruton, troxerutin, the complex diosmin-hesperidin, Antistax, Mirtoselect (bilberry), escin, and the combination Venoruton-Pycnogenol (VE-PY) against the therapeutic compressions.
The study included 1,051 patients who completed the registry. During the experiment, there are no safety or tolerability problems observed.
Mirtoselect (bilberry) showed a significant effect on skin flux but in a lesser extent compared to those of Venoruton, Pycnogenol, and the combination VE-PY.
The edema score was decreased more effectively with the combination and with Pycnogenol compared to the other treatment group including the Mirtoselect (bilberry).
According to the improvement in symptoms score, Pycnogenol and compression showed a larger decrease in oxidative stress compared to the Pycnogenol, Venoruton, Mirtoselect (bilberry) and with the VE-PY combination.
However, the efficacy of Pycnogenol and the combination are competitive with stockings that do not have the same tolerability in warmer climates compared to other groups.
The findings suggested that the tested compounds processed anti chronic venous insufficiency (CVI) and varicose veins properties.
Taken altogether, Mirtoselect (bilberry) may be considered a functioning remedy for the treatment of varicose veins with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Management of Varicose Veins and Chronic Venous Insufficiency in a Comparative Registry with Nine Venoactive Products in Comparison with Stockings by Belcaro G1, Dugall M1, Luzzi R1, Corsi M1, Ledda A1, Ricci A1, Pellegrini L1, Cesarone MR1, Hosoi M1, Errichi BM1, Cornelli U1, Cotellese R1, Agus G1, Feragalli B. (PubMed)
(2) Age-related variations of varicose veins anatomy by Caggiati A1, Rosi C, Heyn R, Franceschini M, Acconcia MC. (PubMed)
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