Gingivitis or gingival inflammation is a condition of inflammation of the gum caused by overexpression of plaques accumulated on your teeth that irritate the gingiva. Over time, the gum of an infected person has become swollen and bleed easily.
In severe cases, the condition can lead to periodontal disease, inducing tooth decay or loss of the tooth.
Most of the cases of gingivitis are associated with poor hygiene, particularly in people who smoke.
Patients can reverse gingivitis if they follow a good oral health habit, including brushing at least twice a day, flossing daily, and getting regular dental checkups.
Most common symptoms of gingivitis including swollen gums with dusky red or dark red color and bleeding easily when brush or floss, particularly breath-breath.
According to the statistics provided by the CDC, smoking is an important cause of severe gum disease in the US.
Dr. Fouad H. Al-Bayaty, the lead scientist in the study of "The Influence of Cigarette Smoking on Gingival Bleeding and Serum Concentrations of Haptoglobin and Alpha 1-Antitrypsin" wrote,
"Duration of smoking (years) and the cotinine level in serum showed a significant correlation with plaque index. The present analysis demonstrated that the duration of smoking in years, but not the number of cigarettes smoked per day, was associated with reduced gingival bleeding in smokers".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find a natural source for the treatment of gingival inflammation, researchers investigated the effect of bilberry consumption on the outcome of routine dental clinical parameters such as inflammation, bleeding on probing (BOP), and biomarkers of inflammation.
The study included individuals who did not receive standard of care treatment allocated to either a placebo group or to groups that consumed either 250 or 500 g bilberries daily over seven days compared to the placebo group consumed an inactive product (starch).
During the study, The mean of the groups that consumed either 250 or 500 g of bilberries/day showed a reduction in BOP before and after consumption of test product over 1 week was 41% and 59% compared to 31% in the placebo group, and 58% in the standard of a care reference group.
The group that consumed 500 g of bilberries/day also showed a significant reduction of the pro-inflammatory cytokine levels compared to consumed 250 g of bilberries/day group.
The results strongly suggested that bilberry inhibited proinflammatory proteins linearly in dose dependent-manner observed by the reduction of levels of IL-1b, IL-6, and VEGF.
Based on the findings, researchers wrote, " It appears that berry intake has an ameliorating effect on some markers of gingival inflammation-reducing gingivitis to a similar extent compared to standard of care".
Taken altogether, bilberry may be considered a functioning remedy for the treatment of gingival inflammation, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Consumption of bilberries controls gingival inflammation by Widén C1, Coleman M2, Critén S3, Karlgren-Andersson P4, Renvert S5,6,7, Persson GR. (PubMed)
(2) The Influence of Cigarette Smoking on Gingival Bleeding and Serum Concentrations of Haptoglobin and Alpha 1-Antitrypsin by Fouad H. Al-Bayaty,1 NorAdinar Baharuddin,2 Mahmood A. Abdulla,3 Hapipah Mohd Ali,4 Magaji B. Arkilla,5 and Mustafa F. ALBayaty. (Hindawi)
Sunday, July 12, 2020
Saturday, July 11, 2020
Artichoke, the Potential Anti Mesothelioma Remedy, According to Researchers
Mesothelioma is a type of cancer that develops from the thin layer of tissue known as the mesothelium.
Most cases of mesothelioma are found on the lining of the lungs and chest wall, compared to other organs. Pleural mesothelioma is a cancer of the pleural lining of the lung.
Exposure to asbestos which has been banned is one of the most common causes of the disease. Some researchers suggested that inhaling asbestos can cause mesothelioma in many ways, including
* Induced chronic low-grade inflammation of mesothelial cells as the immune system can not completely drive out the fibers that cause damage to the lung, leading to the compromise.
* Long-term exposure of the asbestos can suppress the genes associated with limited cell cycle division and tumor suppression
* Long-term exposure is also found to alter the cell DNA, leading to cancer.
According to statistics, 2000 to 3,000 people are diagnosed with mesothelioma each year in the United States. The asbestos risk of pleural mesothelioma is in the range of 2 to 10 percent.
Most cases of malignant mesothelioma are closely associated with past occupational exposure.
However, asbestos is found persistently in our natural and built environments.
Besides most common cancer symptoms, patients with pleural mesothelioma at the advanced stage may also experience symptoms of dry cough or wheezing, shortness of breath (dyspnea), respiratory complications and pain in the chest or abdomen.
Some patients may also develop pleural effusion (fluid around the lungs), fever or night sweats, fatigue, and muscle weakness
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
In the concern of the malignant pleural mesothelioma, a poorly treated neoplasia by conventional medicine, arising from the pleural mesothelial lining, researchers examined leaf extract of Cynara scolymus in vitro and in vivo.
The study included tMSTO-211H, MPP-89 and NCI-H28 mesothelioma cell lines and untransformed mesothelial cells HMC, treated with increasing concentrations (ranging from 3 to 200 μg/ml) of artichoke leaf extract for 72 hrs.
Injection of the leaf extract not only inhibited strongly the cell proliferation but also affected the migration and tumor engraftment in the mesothelioma cell lines.
More precisely, MSTO-211H cells treated with the artichoke extract showed a change in the cellular morphology both in a short-term assay, compared to more resistant more resistance in the HMC cells.
In MSTO-211H, MPP-89 and NCI-H28 cells, injection of artichoke leaf extract inhibited the formation of cancer cell colony.
Astonishingly, dietary feeding with Cynara scolymus leaf extract showed a similar inhibition against the growth of mesothelioma xenografted tumors comparable to those of pemetrexed.
Where pemetrexed is a chemo medicine used for the treatment of cancer, including mesothelioma.
Dr. Claudio Pulito and colleagues suggested, "leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma".
Taken altogether, artichoke leaf extract may be considered a functioning remedy for the prevention and treatment of mesothelioma, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion by Pulito C1, Mori F1, Sacconi A2, Casadei L3, Ferraiuolo M2, Valerio MC3, Santoro R1, Goeman F2, Maidecchi A4, Mattoli L4, Manetti C3, Di Agostino S2, Muti P5, Blandino G2,5, Strano S. (PMC)
Most cases of mesothelioma are found on the lining of the lungs and chest wall, compared to other organs. Pleural mesothelioma is a cancer of the pleural lining of the lung.
Exposure to asbestos which has been banned is one of the most common causes of the disease. Some researchers suggested that inhaling asbestos can cause mesothelioma in many ways, including
* Induced chronic low-grade inflammation of mesothelial cells as the immune system can not completely drive out the fibers that cause damage to the lung, leading to the compromise.
* Long-term exposure of the asbestos can suppress the genes associated with limited cell cycle division and tumor suppression
* Long-term exposure is also found to alter the cell DNA, leading to cancer.
According to statistics, 2000 to 3,000 people are diagnosed with mesothelioma each year in the United States. The asbestos risk of pleural mesothelioma is in the range of 2 to 10 percent.
Most cases of malignant mesothelioma are closely associated with past occupational exposure.
However, asbestos is found persistently in our natural and built environments.
Besides most common cancer symptoms, patients with pleural mesothelioma at the advanced stage may also experience symptoms of dry cough or wheezing, shortness of breath (dyspnea), respiratory complications and pain in the chest or abdomen.
Some patients may also develop pleural effusion (fluid around the lungs), fever or night sweats, fatigue, and muscle weakness
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
In the concern of the malignant pleural mesothelioma, a poorly treated neoplasia by conventional medicine, arising from the pleural mesothelial lining, researchers examined leaf extract of Cynara scolymus in vitro and in vivo.
The study included tMSTO-211H, MPP-89 and NCI-H28 mesothelioma cell lines and untransformed mesothelial cells HMC, treated with increasing concentrations (ranging from 3 to 200 μg/ml) of artichoke leaf extract for 72 hrs.
Injection of the leaf extract not only inhibited strongly the cell proliferation but also affected the migration and tumor engraftment in the mesothelioma cell lines.
More precisely, MSTO-211H cells treated with the artichoke extract showed a change in the cellular morphology both in a short-term assay, compared to more resistant more resistance in the HMC cells.
In MSTO-211H, MPP-89 and NCI-H28 cells, injection of artichoke leaf extract inhibited the formation of cancer cell colony.
Astonishingly, dietary feeding with Cynara scolymus leaf extract showed a similar inhibition against the growth of mesothelioma xenografted tumors comparable to those of pemetrexed.
Where pemetrexed is a chemo medicine used for the treatment of cancer, including mesothelioma.
Dr. Claudio Pulito and colleagues suggested, "leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma".
Taken altogether, artichoke leaf extract may be considered a functioning remedy for the prevention and treatment of mesothelioma, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion by Pulito C1, Mori F1, Sacconi A2, Casadei L3, Ferraiuolo M2, Valerio MC3, Santoro R1, Goeman F2, Maidecchi A4, Mattoli L4, Manetti C3, Di Agostino S2, Muti P5, Blandino G2,5, Strano S. (PMC)
Friday, July 10, 2020
Herbal Ashwagandha Protects the Neuron Against the Onset of Amyotrophic Lateral Sclerosis in Vivo
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or Lou Gehrig's disease, is a type of dementia that causes the death of neurons controlling voluntary muscles.
Dementia is a condition of neurodegeneration syndrome among elders, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgment. Over 47 million of the worldwide population are affected by the disease, mostly in the West.
Free radicals have been found to induce Lou Gehrig's disease. Researchers found that glutamate in the synapses enhances the production of free radicals(77) only in motor nerve cells but spare other nerve cells. such as cells control senses and other body functions, causing disruption of astrocytes in regulated glutamate levels.
Maintaining a balanced ratio of antioxidant and free radicals is essential for our body to perform a daily physiological function properly.
Truly, if our body is overwhelmed by overexpression of free radicals, it will be weakened by oxidative stress, causing adversely altered lipids, proteins, and DNA that can trigger a number of human diseases(a), including amyotrophic lateral sclerosis.
Free radicals are unstable molecules that contain at least an unpaired electron with function as oxidants or reductants by donating an electron to or accept an electron from other molecules to exhibit chain and domino's effects.
The most common oxygen-containing free radicals found epidemiologically in induced chronic diseases, including hydroxyl radical, superoxide anion radical, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radical, and peroxynitrite radicals.
Antioxidants have been found to reduces the risk of Lou Gehrig's disease by inhibiting the overexpression of free radicals, including
* Vitamin B12 (methylcobalamin)
High doses of vitamin B12 as an antioxidant have shown to improve or slow muscle wasting in the later stages of patients with ALS disease(78)(79).
* Vitamin E
Vitamin E protected against cell membranes from lipid peroxidation damage(80) in reducing the risk of breakdown of the cell membrane cause of ALS(81).
* Superoxide dismutase enzyme
Mutations in the superoxide dismutase enzyme can increase the risk ALS(82) in catalyzing the dismutation of superoxide into oxygen and hydrogen peroxide(83).
* Cerebral cortex
Oxidative stress and DNA alternation triggered neuron damage(84) were found in elevated levels in mice with ALS(85).
* Amino acids
Diet high in amino acids as antioxidants have shown some promising effect in treating ALS(86)(87).
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the treatment of neurological diseases, researchers examined the protective effects of Withania somnifera extract in the SOD1G93A mouse model with amyotrophic lateral sclerosis.
According to the tested analysis, the administration of WS extracts by gavage to mice expressing G93A mutant form of antioxidants superoxide dismutase (SOD1) found in the amyotrophic lateral sclerosis mouse increased longevity, improved motor performance and increased number of motor neurons in the lumbar spinal cord.
In other words, WS extracts inhibited the expression of mutated SOD1 by increasing the cellular chaperons with conformational folding functions.
Furthermore, proteins associated with the induction of pro-inflammatory and pro-apoptosis are also reduced by the injection of WS, through the extracts' immunomodulatory activity.
Moreover, WS extract also induced autophagy at the early stages of the disease, by cleaning out the damaged cells.
Based on the findings, researchers said," WS extracts might constitute promising therapeutics for the treatment of ALS with the involvement of misfolded SOD1".
Taken altogether, Ashwagandha may be considered supplements for the treatment of amyotrophic lateral sclerosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of Withania somnifera extract in SOD1G93A mouse model of amyotrophic lateral sclerosis by Dutta K1, Patel P1, Julien JP. (PubMed)
(2)The holistic Prevention, Management, and Treatment of Dementia - Free radical causes of Lou Gehrig's disease(Amyotrophic lateral sclerosis) by Kyle J. Norton
Dementia is a condition of neurodegeneration syndrome among elders, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgment. Over 47 million of the worldwide population are affected by the disease, mostly in the West.
Free radicals have been found to induce Lou Gehrig's disease. Researchers found that glutamate in the synapses enhances the production of free radicals(77) only in motor nerve cells but spare other nerve cells. such as cells control senses and other body functions, causing disruption of astrocytes in regulated glutamate levels.
Maintaining a balanced ratio of antioxidant and free radicals is essential for our body to perform a daily physiological function properly.
Truly, if our body is overwhelmed by overexpression of free radicals, it will be weakened by oxidative stress, causing adversely altered lipids, proteins, and DNA that can trigger a number of human diseases(a), including amyotrophic lateral sclerosis.
Free radicals are unstable molecules that contain at least an unpaired electron with function as oxidants or reductants by donating an electron to or accept an electron from other molecules to exhibit chain and domino's effects.
The most common oxygen-containing free radicals found epidemiologically in induced chronic diseases, including hydroxyl radical, superoxide anion radical, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radical, and peroxynitrite radicals.
Antioxidants have been found to reduces the risk of Lou Gehrig's disease by inhibiting the overexpression of free radicals, including
* Vitamin B12 (methylcobalamin)
High doses of vitamin B12 as an antioxidant have shown to improve or slow muscle wasting in the later stages of patients with ALS disease(78)(79).
* Vitamin E
Vitamin E protected against cell membranes from lipid peroxidation damage(80) in reducing the risk of breakdown of the cell membrane cause of ALS(81).
* Superoxide dismutase enzyme
Mutations in the superoxide dismutase enzyme can increase the risk ALS(82) in catalyzing the dismutation of superoxide into oxygen and hydrogen peroxide(83).
* Cerebral cortex
Oxidative stress and DNA alternation triggered neuron damage(84) were found in elevated levels in mice with ALS(85).
* Amino acids
Diet high in amino acids as antioxidants have shown some promising effect in treating ALS(86)(87).
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the treatment of neurological diseases, researchers examined the protective effects of Withania somnifera extract in the SOD1G93A mouse model with amyotrophic lateral sclerosis.
According to the tested analysis, the administration of WS extracts by gavage to mice expressing G93A mutant form of antioxidants superoxide dismutase (SOD1) found in the amyotrophic lateral sclerosis mouse increased longevity, improved motor performance and increased number of motor neurons in the lumbar spinal cord.
In other words, WS extracts inhibited the expression of mutated SOD1 by increasing the cellular chaperons with conformational folding functions.
Furthermore, proteins associated with the induction of pro-inflammatory and pro-apoptosis are also reduced by the injection of WS, through the extracts' immunomodulatory activity.
Moreover, WS extract also induced autophagy at the early stages of the disease, by cleaning out the damaged cells.
Based on the findings, researchers said," WS extracts might constitute promising therapeutics for the treatment of ALS with the involvement of misfolded SOD1".
Taken altogether, Ashwagandha may be considered supplements for the treatment of amyotrophic lateral sclerosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of Withania somnifera extract in SOD1G93A mouse model of amyotrophic lateral sclerosis by Dutta K1, Patel P1, Julien JP. (PubMed)
(2)The holistic Prevention, Management, and Treatment of Dementia - Free radical causes of Lou Gehrig's disease(Amyotrophic lateral sclerosis) by Kyle J. Norton
Thursday, July 9, 2020
Bromelin Inhibits Symptoms in Patients with Functional Dyspepsia
Functional dyspepsia, also known as indigestion, is a symptom in the stomach associated with difficulty in digesting food.
The most common symptoms of indigestion are pain or discomfort in your upper abdomen (dyspepsia) or burning pain behind the breastbone (heartburn) soon after eating.
Some patients may also experience symptoms of feeling full or bloated with no signs of relief.
In serious cases, patients may also experience symptoms of vomiting blood, dark, tarry stools due to damage to the lining of the stomach, shortness of breath, and unexplained weight loss.
If you have some of the aforementioned symptoms, please check with the doctor immediately
There exact causes of indigestion are multiple. Epidemiologically, female gender, aging, long-term use of pain relievers, such as aspirin and ibuprofen, smoking and people with long-term psychological problems such as anxiety or depression are some most common factors found in patients with functional dyspepsia.
Conventionally, treatment of functional dyspepsia is totally depending on the condition, including antibiotics for H. pylori infection and medication to reduce pain.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding potential and natural compounds for the treatment of functional dyspepsia, researchers examined a dietary integrator composed of sodium alginate, sodium bicarbonate, bromelin and essential oils on patients affected by functional dyspepsia.
The study included a study of a total of 100 patients with functional dyspepsia diagnosed primarily on the basis of typical symptoms and the exclusion of non-functional gastrointestinal diseases.
According to the symptom classification, All patients were assigned to either dysmotility-like dyspepsia (N.=60) or reflux-like dyspepsia (N.=40).
All patients were treated with TUBES Gastro (0.80 g oral tablets bid after main meals) for 4 weeks, on top of their current treatment with proton pump inhibitors or not.
According to the results from the experiment, TUBES Gastro showed a high statistically significant reduction of the Numerical Rating Scale (NRS) scores at 14 and 28 days: -1.5 (-26.3%) and -3.4 (-59.6%), respectively compared to the baseline in patients with dysmotility-like dyspepsia.
In patients with reflux-like dyspepsia, TUBES Gastro demonstrated a statistically significant reduction of the NRS score at 14 and 28 days: -2.8 (-41.2%) and -4.8 (70.6%), respectively (P<0.0001).
Furthermore, there were no side effects found during the study duration.
Based on the findings, researchers wrote, "TUBES Gastro treatment was effective and well-tolerated in reducing the symptomatology of patients affected by functional dysmotility-like and reflux-like dyspepsia".
In order to reveal additional information of TUBES Gastro anti-functional dyspepsia, researchers at the Molinette Hospital conducted a study to examine the preparation efficacy of a total of 53 consecutive patients (22 males, 31 females; mean age, 54+/-2.5 years) with functional dyspepsia and negative for Helicobacter pylori infection.
Patients classified into four subgroups according to predominant symptom: ulcer-like dyspepsia, Motility-like dyspepsia, reflux-like dyspepsia, and nonspecific dyspepsia, were received TUBES gastro (0.80 g oral tablets bid) for a minimum of 3 months (range, 3-11).
According to the results of patients who completed the study, the preparation showed a strong effect on the improvement in Visual Analogue Scale (VAS). score.
Compared to the based line, the difference in scores between the initial and the final visit was -1.9+/-2.1 cm (range, -6 to +3), or 23.8+/-40.8% (range, -150% to 100%).
Dr. Pellicano R, the lead scientists wrote, "The study results indicate that in the short term TUBES gastro can significantly improve dyspeptic symptoms in dyspeptic patients negative for H. pylori infection".
Taken altogether, bromelain used alone or combined with other remedies may be considered supplements for the prevention and treatment of functional dyspepsia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Can dietary integrators provide a clinical benefit in the treatment of functionaldyspepsia? results from a prospective study with TUBES Gastro by Molteni M. (PubMed)
(2) Benefit of dietary integrators for treating functional dyspepsia: a prospective pilot study.[Article in English, Italian] by Pellicano R1, Strona S, Simondi D, Reggiani S, Pallavicino F, Sguazzini C, Bonagura AG, Rizzetto M, Astegiano M. (PubMed)
The most common symptoms of indigestion are pain or discomfort in your upper abdomen (dyspepsia) or burning pain behind the breastbone (heartburn) soon after eating.
Some patients may also experience symptoms of feeling full or bloated with no signs of relief.
In serious cases, patients may also experience symptoms of vomiting blood, dark, tarry stools due to damage to the lining of the stomach, shortness of breath, and unexplained weight loss.
If you have some of the aforementioned symptoms, please check with the doctor immediately
There exact causes of indigestion are multiple. Epidemiologically, female gender, aging, long-term use of pain relievers, such as aspirin and ibuprofen, smoking and people with long-term psychological problems such as anxiety or depression are some most common factors found in patients with functional dyspepsia.
Conventionally, treatment of functional dyspepsia is totally depending on the condition, including antibiotics for H. pylori infection and medication to reduce pain.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding potential and natural compounds for the treatment of functional dyspepsia, researchers examined a dietary integrator composed of sodium alginate, sodium bicarbonate, bromelin and essential oils on patients affected by functional dyspepsia.
The study included a study of a total of 100 patients with functional dyspepsia diagnosed primarily on the basis of typical symptoms and the exclusion of non-functional gastrointestinal diseases.
According to the symptom classification, All patients were assigned to either dysmotility-like dyspepsia (N.=60) or reflux-like dyspepsia (N.=40).
All patients were treated with TUBES Gastro (0.80 g oral tablets bid after main meals) for 4 weeks, on top of their current treatment with proton pump inhibitors or not.
According to the results from the experiment, TUBES Gastro showed a high statistically significant reduction of the Numerical Rating Scale (NRS) scores at 14 and 28 days: -1.5 (-26.3%) and -3.4 (-59.6%), respectively compared to the baseline in patients with dysmotility-like dyspepsia.
In patients with reflux-like dyspepsia, TUBES Gastro demonstrated a statistically significant reduction of the NRS score at 14 and 28 days: -2.8 (-41.2%) and -4.8 (70.6%), respectively (P<0.0001).
Furthermore, there were no side effects found during the study duration.
Based on the findings, researchers wrote, "TUBES Gastro treatment was effective and well-tolerated in reducing the symptomatology of patients affected by functional dysmotility-like and reflux-like dyspepsia".
In order to reveal additional information of TUBES Gastro anti-functional dyspepsia, researchers at the Molinette Hospital conducted a study to examine the preparation efficacy of a total of 53 consecutive patients (22 males, 31 females; mean age, 54+/-2.5 years) with functional dyspepsia and negative for Helicobacter pylori infection.
Patients classified into four subgroups according to predominant symptom: ulcer-like dyspepsia, Motility-like dyspepsia, reflux-like dyspepsia, and nonspecific dyspepsia, were received TUBES gastro (0.80 g oral tablets bid) for a minimum of 3 months (range, 3-11).
According to the results of patients who completed the study, the preparation showed a strong effect on the improvement in Visual Analogue Scale (VAS). score.
Compared to the based line, the difference in scores between the initial and the final visit was -1.9+/-2.1 cm (range, -6 to +3), or 23.8+/-40.8% (range, -150% to 100%).
Dr. Pellicano R, the lead scientists wrote, "The study results indicate that in the short term TUBES gastro can significantly improve dyspeptic symptoms in dyspeptic patients negative for H. pylori infection".
Taken altogether, bromelain used alone or combined with other remedies may be considered supplements for the prevention and treatment of functional dyspepsia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Can dietary integrators provide a clinical benefit in the treatment of functionaldyspepsia? results from a prospective study with TUBES Gastro by Molteni M. (PubMed)
(2) Benefit of dietary integrators for treating functional dyspepsia: a prospective pilot study.[Article in English, Italian] by Pellicano R1, Strona S, Simondi D, Reggiani S, Pallavicino F, Sguazzini C, Bonagura AG, Rizzetto M, Astegiano M. (PubMed)
Wednesday, July 8, 2020
Herbal Bilberry Normalizes the Angiogenesis In the Body
Angiogenesis refers to the formation of new blood vessels from the existing vasculature.
Angiogenesis, on one hand, plays a critical role in repairing tissue damages including arteriosclerosis, myocardial infarction. On another hand, the expression of angiogenesis has been found to cause diseases and induce the progression of retinopathies, benign tumors, and cancer.
In other words, abnormal blood vessel growth that cause either excessive or insufficient has been linked to underlying many deadly and debilitating conditions.
Under normal conditions, the development of angiogenesis totally depends on the functional demands of the body. For example, exercise stimulates angiogenesis in skeletal muscle and heart and a lack of exercise can lead to capillary regression.
Clearly, these results demonstrated the need for angiogenesis for the body to function better and the formation of new blood vessels occurs throughout human life.
However, in the cancer perspective, new blood vessel growth is important for cancer proliferation and metastatic spread. The survival of tumor cells totally depends on an adequate supply of oxygen and nutrients.
Dr. the lead scientist said, "Levels of expression of angiogenic factors reflect the aggressiveness of tumor cells. The discovery of angiogenic inhibitors should help to reduce both morbidity and mortality from carcinomas".
In other words, if we can stop the tumor in stimulating the production of new blood vessels to supply energy for them to grow, we may cure cancer.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find potential treatment for diseases associated with angiogenesis,with no side effects, researchers examined the antiangiogenic properties and antioxidant activities (a) of the main anthocyanidins (delphinidin, cyanidin, and malvidin) found as constituents in Vaccinium myrtillus (bilberry) anthocyanosides (VMA) and (b) of N-acetyl-L-cysteine (NAC).
Anthocyanidins exerted a significant inhibition of vascular endothelial growth factor (VEGF) associated with the growth of new blood vessels in a concentration-dependent manner.
Anthocyanidin at 3 and/or 10 microM are the most effective compared to those of NAC at 1 microM (the only concentration tested).
Moreover, both anthocyanidin (0.3-10 microM) and NAC (1-1000 microM) concentration-dependently also exerted a significantly scavenged the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical.
The findings suggested that VMA processes an anti-angiogenic activity depending on the main constituent anthocyanidins (delphinidin, cyanidin, and malvidin), presumably via antioxidant effects.
Additionally, in vitro and in vivo, Vaccinium myrtillus (Bilberry) extracts (VME) showed an anti-angiogenic effect on 0.3-30 µg ml(-1)) compared to those of GM6001 (0.1-100 µM; a matrix metalloproteinase inhibitor).
In human umbilical vein endothelial cells (HUVECs), VME inhibited VEGF-A-induced proliferation of HUVECs.
According to the vivo assay, intravitreal administration of VME inhibited the formation of neovascular tufts during oxygen-induced retinopathy in mice.
The results suggested that VME may be effective against retinal diseases involving angiogenesis.
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of diseases involved angiogenesis, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Inhibitory actions of bilberry anthocyanidins on angiogenesis by Matsunaga N1, Tsuruma K, Shimazawa M, Yokota S, Hara H. (PubMed)
(2) Vaccinium myrtillus (Bilberry) Extracts Reduce Angiogenesis In Vitro and In Vivo by Matsunaga N1, Chikaraishi Y, Shimazawa M, Yokota S, Hara H. (PubMed)
(3) Angiogenesis in Cancer by Naoyo Nishida,1,2 Hirohisa Yano,1 Takashi Nishida,3 Toshiharu Kamura,2 andMasamichi Kojiro. (PMC)
Angiogenesis, on one hand, plays a critical role in repairing tissue damages including arteriosclerosis, myocardial infarction. On another hand, the expression of angiogenesis has been found to cause diseases and induce the progression of retinopathies, benign tumors, and cancer.
In other words, abnormal blood vessel growth that cause either excessive or insufficient has been linked to underlying many deadly and debilitating conditions.
Under normal conditions, the development of angiogenesis totally depends on the functional demands of the body. For example, exercise stimulates angiogenesis in skeletal muscle and heart and a lack of exercise can lead to capillary regression.
Clearly, these results demonstrated the need for angiogenesis for the body to function better and the formation of new blood vessels occurs throughout human life.
However, in the cancer perspective, new blood vessel growth is important for cancer proliferation and metastatic spread. The survival of tumor cells totally depends on an adequate supply of oxygen and nutrients.
Dr. the lead scientist said, "Levels of expression of angiogenic factors reflect the aggressiveness of tumor cells. The discovery of angiogenic inhibitors should help to reduce both morbidity and mortality from carcinomas".
In other words, if we can stop the tumor in stimulating the production of new blood vessels to supply energy for them to grow, we may cure cancer.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find potential treatment for diseases associated with angiogenesis,with no side effects, researchers examined the antiangiogenic properties and antioxidant activities (a) of the main anthocyanidins (delphinidin, cyanidin, and malvidin) found as constituents in Vaccinium myrtillus (bilberry) anthocyanosides (VMA) and (b) of N-acetyl-L-cysteine (NAC).
Anthocyanidins exerted a significant inhibition of vascular endothelial growth factor (VEGF) associated with the growth of new blood vessels in a concentration-dependent manner.
Anthocyanidin at 3 and/or 10 microM are the most effective compared to those of NAC at 1 microM (the only concentration tested).
Moreover, both anthocyanidin (0.3-10 microM) and NAC (1-1000 microM) concentration-dependently also exerted a significantly scavenged the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical.
The findings suggested that VMA processes an anti-angiogenic activity depending on the main constituent anthocyanidins (delphinidin, cyanidin, and malvidin), presumably via antioxidant effects.
Additionally, in vitro and in vivo, Vaccinium myrtillus (Bilberry) extracts (VME) showed an anti-angiogenic effect on 0.3-30 µg ml(-1)) compared to those of GM6001 (0.1-100 µM; a matrix metalloproteinase inhibitor).
In human umbilical vein endothelial cells (HUVECs), VME inhibited VEGF-A-induced proliferation of HUVECs.
According to the vivo assay, intravitreal administration of VME inhibited the formation of neovascular tufts during oxygen-induced retinopathy in mice.
The results suggested that VME may be effective against retinal diseases involving angiogenesis.
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of diseases involved angiogenesis, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Inhibitory actions of bilberry anthocyanidins on angiogenesis by Matsunaga N1, Tsuruma K, Shimazawa M, Yokota S, Hara H. (PubMed)
(2) Vaccinium myrtillus (Bilberry) Extracts Reduce Angiogenesis In Vitro and In Vivo by Matsunaga N1, Chikaraishi Y, Shimazawa M, Yokota S, Hara H. (PubMed)
(3) Angiogenesis in Cancer by Naoyo Nishida,1,2 Hirohisa Yano,1 Takashi Nishida,3 Toshiharu Kamura,2 andMasamichi Kojiro. (PMC)
Tuesday, July 7, 2020
Herbal Artichoke, The Potent Anti Liver Cancer Natural Remedy
Artichoke may have potential and positive effects in protecting the liver against the onset of liver diseases, according to studies.
The liver is the large organ in the human body that processed a significant activity on filtering the blood coming from the digestive tract, before passing it to the rest of the body.
Furthermore, the function of the liver also includes removing and breaking down most drugs and chemicals from your bloodstream and toxins created byproducts that can damage the liver and the body.
However, long-term and persistent exposure to toxic substances can cause serious damage, sometimes irreversible harm to the liver.
Liver cancer is a medical condition characterized by irregular cell growth due to the alternation of liver cell DNA.
Most common metastasis of primary liver cancer is breast, colorectal cancer, and esophageal cancer.
Most cases of primary liver cancer start in the cells on the surface of the inner lining of the liver tissues. Due to the small size of the tumor at the early stage, most patients with liver cancer do not experience any symptoms.
Genetic preposition, hepatitis viral infection, alcohol abuse, and cirrhosis are common risk factor associated with the onset of liver cancer.
According to the statistics, 43% of people who are diagnosed at an early stage have a 5-year survival rate of 31% compared to that of 3 to 5% at the advanced stage.
In the Western world, more than half of all people diagnosed with primary liver cancer have cirrhosis, a scarring condition of the liver commonly caused by alcohol abuse.
Dr.Elliot B Tapper, in the investigation of the alcoholic risk of liver cancer mortality in the US, said, "Mortality due to cirrhosis has been increasing in the US since 2009. Driven by deaths due to alcoholic cirrhosis, people aged 25-34 have experienced the greatest relative increase in mortality. White Americans, Native Americans, and Hispanic Americans experienced the greatest increase in deaths from cirrhosis".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of liver cancer with no side effects evaluated the effect of fish oil and Artichoke (Cynara scolymus I.) against diethylnitrosamine (DEN) induced hepatocellular carcinoma in rats.
Rats selected into the study were divided into 8 groups. Group 1, control rats. Group 2: rats injected with a single dose of DEN (100 mg/kg body weight). Groups 3-8 supplemented with different concentrations of either fish oil or artichoke for 25 days before DEN injection.
DEN injected group not only showed a significant decrease in levels fo antioxidant enzymes produced by the host but also exhibited the overexpression of free radical formation and oxidative stress marker.
Furthermore, Den injected group also showed the increased inflammatory cytokines and stimulated protein associated with forming new blood vessels for cancer growth accompanied by liver damage through the expression of liver function markers.
Moreover, the administration of DEN also affected the liver cell through the occurrence of hepatic cellular degeneration and necrosis.
Treatment with fish oil (5%, 10%) or artichoke heads or leaves (0.5, 1 g) for 25 days displayed a significant amelioration of DEN-induced changes in the biochemical parameters.
In the depth analysis, the administration of fish oil (5%, 10%) or artichoke heads or leaves (0.5, 1 g) fish oil (5%, 10%) or artichoke heads or leaves (0.5, 1 g) almost restored the liver functioning in treated groups, compared to the controls.
Dr. Metwally NS and colleagues in the final report wrote, "The results pointed out that 10% fish oil and 1 g% leaves of artichoke succeeded to protect from hepatocellular carcinoma to a certain degree. In addition, they may be considered as protective foods against angiogenesis".
In order to reveal more information about the artichoke anti-liver cancer activity, researchers examined the polyphenolic extracts from an edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells.
On hepatocytes exposed to H2O2generated in situ by glucose oxidase, injection of AE not only restored the levels of antioxidant enzymes from the host but also decreased the oxidative stress marker in the liver.
In other words, AE protected the liver against lipid peroxidation and cell death and prevented the loss of total GSH and the accumulation of MDA.
Additionally, AE also reduced cell viability in a dose-dependent manner in HepG2 cells in 24 h.
In liver cancer cell lines, AE induced liver protective activity by activating the proteins associated with cell apoptosis, according to the flow cytometric analysis of annexin.
Dr. Miccadei S, the lead scientist said, "AE had a marked antioxidative potential that protects hepatocytes from oxidative stress. Furthermore, AE reduced cell viability and had an apoptotic activity on a human liver cancer cell line".
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of liver cancer, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(2) The protective effects of fish oil and artichoke on hepatocellular carcinoma in rats by Metwally NS1, Kholeif TE, Ghanem KZ, Farrag AR, Ammar NM, Abdel-Hamid AH. (PubMed)
(2) Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells by Miccadei S1, Di Venere D, Cardinali A, Romano F, Durazzo A, Foddai MS, Fraioli R, Mobarhan S, Maiani G. (PubMed)
(3) Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study by Elliot B Tapper, and Neehar D Parikh. (the BMJ)
The liver is the large organ in the human body that processed a significant activity on filtering the blood coming from the digestive tract, before passing it to the rest of the body.
Furthermore, the function of the liver also includes removing and breaking down most drugs and chemicals from your bloodstream and toxins created byproducts that can damage the liver and the body.
However, long-term and persistent exposure to toxic substances can cause serious damage, sometimes irreversible harm to the liver.
Liver cancer is a medical condition characterized by irregular cell growth due to the alternation of liver cell DNA.
Most common metastasis of primary liver cancer is breast, colorectal cancer, and esophageal cancer.
Most cases of primary liver cancer start in the cells on the surface of the inner lining of the liver tissues. Due to the small size of the tumor at the early stage, most patients with liver cancer do not experience any symptoms.
Genetic preposition, hepatitis viral infection, alcohol abuse, and cirrhosis are common risk factor associated with the onset of liver cancer.
According to the statistics, 43% of people who are diagnosed at an early stage have a 5-year survival rate of 31% compared to that of 3 to 5% at the advanced stage.
In the Western world, more than half of all people diagnosed with primary liver cancer have cirrhosis, a scarring condition of the liver commonly caused by alcohol abuse.
Dr.Elliot B Tapper, in the investigation of the alcoholic risk of liver cancer mortality in the US, said, "Mortality due to cirrhosis has been increasing in the US since 2009. Driven by deaths due to alcoholic cirrhosis, people aged 25-34 have experienced the greatest relative increase in mortality. White Americans, Native Americans, and Hispanic Americans experienced the greatest increase in deaths from cirrhosis".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of liver cancer with no side effects evaluated the effect of fish oil and Artichoke (Cynara scolymus I.) against diethylnitrosamine (DEN) induced hepatocellular carcinoma in rats.
Rats selected into the study were divided into 8 groups. Group 1, control rats. Group 2: rats injected with a single dose of DEN (100 mg/kg body weight). Groups 3-8 supplemented with different concentrations of either fish oil or artichoke for 25 days before DEN injection.
DEN injected group not only showed a significant decrease in levels fo antioxidant enzymes produced by the host but also exhibited the overexpression of free radical formation and oxidative stress marker.
Furthermore, Den injected group also showed the increased inflammatory cytokines and stimulated protein associated with forming new blood vessels for cancer growth accompanied by liver damage through the expression of liver function markers.
Moreover, the administration of DEN also affected the liver cell through the occurrence of hepatic cellular degeneration and necrosis.
Treatment with fish oil (5%, 10%) or artichoke heads or leaves (0.5, 1 g) for 25 days displayed a significant amelioration of DEN-induced changes in the biochemical parameters.
In the depth analysis, the administration of fish oil (5%, 10%) or artichoke heads or leaves (0.5, 1 g) fish oil (5%, 10%) or artichoke heads or leaves (0.5, 1 g) almost restored the liver functioning in treated groups, compared to the controls.
Dr. Metwally NS and colleagues in the final report wrote, "The results pointed out that 10% fish oil and 1 g% leaves of artichoke succeeded to protect from hepatocellular carcinoma to a certain degree. In addition, they may be considered as protective foods against angiogenesis".
In order to reveal more information about the artichoke anti-liver cancer activity, researchers examined the polyphenolic extracts from an edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells.
On hepatocytes exposed to H2O2generated in situ by glucose oxidase, injection of AE not only restored the levels of antioxidant enzymes from the host but also decreased the oxidative stress marker in the liver.
In other words, AE protected the liver against lipid peroxidation and cell death and prevented the loss of total GSH and the accumulation of MDA.
Additionally, AE also reduced cell viability in a dose-dependent manner in HepG2 cells in 24 h.
In liver cancer cell lines, AE induced liver protective activity by activating the proteins associated with cell apoptosis, according to the flow cytometric analysis of annexin.
Dr. Miccadei S, the lead scientist said, "AE had a marked antioxidative potential that protects hepatocytes from oxidative stress. Furthermore, AE reduced cell viability and had an apoptotic activity on a human liver cancer cell line".
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of liver cancer, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(2) The protective effects of fish oil and artichoke on hepatocellular carcinoma in rats by Metwally NS1, Kholeif TE, Ghanem KZ, Farrag AR, Ammar NM, Abdel-Hamid AH. (PubMed)
(2) Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells by Miccadei S1, Di Venere D, Cardinali A, Romano F, Durazzo A, Foddai MS, Fraioli R, Mobarhan S, Maiani G. (PubMed)
(3) Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study by Elliot B Tapper, and Neehar D Parikh. (the BMJ)
Monday, July 6, 2020
Bromelain, a Natural Prevention and Treatment of Chronic Constipation
Constipation is a condition of hard and dry stool that are infrequent or hard to pass.
Acute constipation caused by staying in a sitting position for long periods of time that kinks up the colon and restrain stool from passing through can be reversed in a few days with or without the use of
a laxative or over the counter medicine
Chronic constipation is a condition characterized by difficult, infrequent, or perceived incomplete evacuation of bowel movements with less than 3 bowel movement a week.
In most cases, chronic constipation with no structural and medical problems is normally caused by long-term an unhealthy diet with low fiber.
Certain medications calcium channel blockers, narcotics are also found to induce constipation.
According to the recommendation of the health professionals, total fiber intake per day is 25-35 grams, depending on your sex, age, and weight for people with or without the condition of constipation.
Some people taking total fiber intake per day is 25-35 grams may experience symptoms of excess colon gas and flatus. In this instance, soluble fiber should be cut down on first before cutting down of insoluble fiber.
More precisely, a high fiber diet must be accompanied by increased fluid intake and moderate exercise for maintaining good colon health against constipation in patients with no structural and medical problem.
According to the statistics, in the US, approximately 4 million people have frequent constipation, affecting about 2 percent of Americans. Constipation also is the most common digestive complaint in the US, outnumbering all other chronic digestive conditions.
Some researchers suggested that there is a correlation between aging in the risk of constipation.
Dr. Brenda G. Schuster wrote, "Constipation is a common complaint and challenge for older adults. The prevalence of constipation increases with age and differs among settings. In individuals 65 years of age or older in the community, the prevalence is 26% for women and 16% for men.1
And "This rate increases to 34% for women and 26% for men in those 84 years of age and older.1For long-term care residents, the prevalence is as high as 80%".
In other words, adults who are 65 years of age are at a higher risk of constipation.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a natural laxative compound for the treatment of chronic constipation, researchers examined the effect of bromelain (EC 3.4.22.33) isolated and purified from pineapple fruit on constipation.
In rat constipation induced gavage administration of loperamide hydrochloride treated by bromelain, showed significant relief of the high visceral sensitivity and infrequent stools in constipated rats.
Furthermore, bromelain treated rats also reversed the slow gastric emptying and intestinal transit.
Moreover, bromelain relieved constipation in tested rats by stimulating intestinal contraction
The efficacy of anti-constipation of bromelain was attributed to significantly reverse the decrease of phosphorylation of the 20 kDa regulatory light chain of myosin (p-MLC20) associated with cellular functions such as muscle contraction, mitosis, and cytokinesis. and the expression of MLCK associated with gastro emptying and intestinal transit in constipation-predominant.
In other words, bromelain efficacy on constipation is to promote mechanisms involved in increased gut motility.
Based on the findings, researchers said, "The beneficial effect of pineapple on constipation is partly dependent on fruit bromelain although the fibers and fluid in pineapple juice are also beneficial".
Taken altogether, bromelain may be considered a remedy for the prevention and treatment of chronic constipation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fruit bromelain ameliorates rat constipation induced by loperamide by Zijuan Zhou‡ a, Liang Wang‡a, Ming Xu‡b, Lianhong Yin, Fang Yang, Simei Huic, Yanlin Yi, Panpan Fenga, Jingyu Wanga, Yuan Lin*b, Jinyong Peng and Dapeng Chen. (the Royal Society of Chemistry)
(3) Constipation in older adults. A stepwise approach to keep things moving by Brenda G. Schuster, Lynette Kosar, and Rejina Kamrul (PMC)
Acute constipation caused by staying in a sitting position for long periods of time that kinks up the colon and restrain stool from passing through can be reversed in a few days with or without the use of
a laxative or over the counter medicine
Chronic constipation is a condition characterized by difficult, infrequent, or perceived incomplete evacuation of bowel movements with less than 3 bowel movement a week.
In most cases, chronic constipation with no structural and medical problems is normally caused by long-term an unhealthy diet with low fiber.
Certain medications calcium channel blockers, narcotics are also found to induce constipation.
According to the recommendation of the health professionals, total fiber intake per day is 25-35 grams, depending on your sex, age, and weight for people with or without the condition of constipation.
Some people taking total fiber intake per day is 25-35 grams may experience symptoms of excess colon gas and flatus. In this instance, soluble fiber should be cut down on first before cutting down of insoluble fiber.
More precisely, a high fiber diet must be accompanied by increased fluid intake and moderate exercise for maintaining good colon health against constipation in patients with no structural and medical problem.
According to the statistics, in the US, approximately 4 million people have frequent constipation, affecting about 2 percent of Americans. Constipation also is the most common digestive complaint in the US, outnumbering all other chronic digestive conditions.
Some researchers suggested that there is a correlation between aging in the risk of constipation.
Dr. Brenda G. Schuster wrote, "Constipation is a common complaint and challenge for older adults. The prevalence of constipation increases with age and differs among settings. In individuals 65 years of age or older in the community, the prevalence is 26% for women and 16% for men.1
And "This rate increases to 34% for women and 26% for men in those 84 years of age and older.1For long-term care residents, the prevalence is as high as 80%".
In other words, adults who are 65 years of age are at a higher risk of constipation.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a natural laxative compound for the treatment of chronic constipation, researchers examined the effect of bromelain (EC 3.4.22.33) isolated and purified from pineapple fruit on constipation.
In rat constipation induced gavage administration of loperamide hydrochloride treated by bromelain, showed significant relief of the high visceral sensitivity and infrequent stools in constipated rats.
Furthermore, bromelain treated rats also reversed the slow gastric emptying and intestinal transit.
Moreover, bromelain relieved constipation in tested rats by stimulating intestinal contraction
The efficacy of anti-constipation of bromelain was attributed to significantly reverse the decrease of phosphorylation of the 20 kDa regulatory light chain of myosin (p-MLC20) associated with cellular functions such as muscle contraction, mitosis, and cytokinesis. and the expression of MLCK associated with gastro emptying and intestinal transit in constipation-predominant.
In other words, bromelain efficacy on constipation is to promote mechanisms involved in increased gut motility.
Based on the findings, researchers said, "The beneficial effect of pineapple on constipation is partly dependent on fruit bromelain although the fibers and fluid in pineapple juice are also beneficial".
Taken altogether, bromelain may be considered a remedy for the prevention and treatment of chronic constipation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fruit bromelain ameliorates rat constipation induced by loperamide by Zijuan Zhou‡ a, Liang Wang‡a, Ming Xu‡b, Lianhong Yin, Fang Yang, Simei Huic, Yanlin Yi, Panpan Fenga, Jingyu Wanga, Yuan Lin*b, Jinyong Peng and Dapeng Chen. (the Royal Society of Chemistry)
(3) Constipation in older adults. A stepwise approach to keep things moving by Brenda G. Schuster, Lynette Kosar, and Rejina Kamrul (PMC)
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